TCM Prescription: Gui Yuan Jin Gu Ning Shi Fu Ji



Prescription Description
Prescription IDTCMF6981
Pinyin NameGui Yuan Jin Gu Ning Shi Fu Ji
Chinese Name归元筋骨宁湿敷剂
English NameGui Yuan Jin Gu Ning Shi Fu Ji
Function Description活血通络, 祛风止痛。用于颈椎病, 肩周炎, 网球肘, 腰椎间盘突出症及腰肌劳损等引起的腰痛。
IndicationsLumbago disorder
Disease ICD-11 Category SC61 [Lumbago disorder (TM1), 腰痛 (TM1) ];
Human Tissues Associated with Indication
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH421 Angelica sinensis 当归 TCMH421 ITSAF173-14
TCMH2376 Corydalis yanhusuo 延胡索 TCMH2376
TCMH258 Paeonia obovata 赤芍 TCMH258 GBVX7902-15
TCMH2238 Siegesbeckiae herba 豨莶草 TCMH2238 GQ434487
TCMH1889 Lycopodium japonicum 伸筋草 TCMH1889 KX302823
TCMH1661 Rhizoma homalomenae occultae 千年健 TCMH1661
TCMH2166 Clematis chinensis 威灵仙 TCMH2166
TCMH1753 Boswellia carterii 乳香 TCMH1753
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT160 HTR7 Serotonin 7 (5-HT7) receptor GPCR P34969
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT187 AR Androgen Receptor Nuclear receptor P10275
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT313 HTR2B Serotonin 2b (5-HT2b) receptor GPCR P41595
TCMT315 HTR6 Serotonin 6 (5-HT6) receptor GPCR P50406
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT34 CYP2D6 Cytochrome P450 2D6 Oxidoreductase P10635
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT36 HTR1A Serotonin 1a (5-HT1a) receptor GPCR P08908
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT37 HTR2A Serotonin 2a (5-HT2a) receptor GPCR P28223
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT377 INSR Insulin receptor Kinase P06213
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT613 NR3C1 Glucocorticoid receptor Nuclear receptor P04150
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT615 SENP8 Sentrin-specific protease 8 Protease Q96LD8
TCMT616 SENP7 Sentrin-specific protease 7 Protease Q9BQF6
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT643 ADRA1A Alpha-1a adrenergic receptor GPCR P35348
TCMT646 HTR5A Serotonin 5a (5-HT5a) receptor GPCR P47898
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT651 DRD3 Dopamine D3 receptor GPCR P35462
TCMT678 XIAP Inhibitor of apoptosis protein 3 Transferase P98170
TCMT679 MPEG1 Macrophage-expressed gene 1 protein Unclassified Q2M385
TCMT680 KAT2B Histone acetyltransferase PCAF Transferase Q92831
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT783 NR3C2 Mineralocorticoid receptor Nuclear receptor P08235
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT853 SIGMAR1 Sigma opioid receptor Unclassified Q99720
TCMT904 PGR Progesterone receptor Nuclear receptor P06401


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1218 Staphylococcus aureus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1289 Shigella dysenteriae
TCMT1294 Human parainfluenza virus 3
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1444 Fusarium oxysporum
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0010647 positive regulation of cell communication ADORA1, ADRA1A, AKR1B1, ALOX15, AR, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, F10, F3, GPR35, HCAR2, HSPA1A, HTR2A, HTR2B, HTR6, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, XDH 11.5107
[BP] GO:0023056 positive regulation of signaling ADORA1, ADRA1A, AKR1B1, ALOX15, AR, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, F10, F3, GPR35, HCAR2, HSPA1A, HTR2A, HTR2B, HTR6, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, XDH 11.5107
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA5A, CA5B, CA6, CA7, CA9 10.2683
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA5A, CA5B, CA6, CA7, CA9 9.32691
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, ADRA1A, AKR1B1, AR, CSNK2A1, CYP1B1, DRD2, DRD3, EGFR, F3, FABP3, HSPA1A, HTR1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MMP2, MMP9, NUAK1, PGR, SMAD3, SRC, TEK, XDH 9.24021
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, ADRA1A, AKR1B1, ALOX15, AR, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, F10, F3, FABP3, FABP4, GPR35, HCAR2, HSD11B1, HSD17B1, HSPA1A, HTR1A, HTR2A, HTR2B, HTR7, INSR, KDR, MET, PPARA, SMAD3, SRC, TEK, XDH 9.24021
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, ADRA1A, AKR1B1, ALOX15, AR, CYP1B1, DRD2, EGFR, F10, F3, GPR35, HSPA1A, HTR2A, HTR2B, HTR6, INSR, KDR, MET, SRC, TEK, XDH 8.47103
[BP] GO:0009967 positive regulation of signal transduction ADORA1, ADRA1A, AKR1B1, ALOX15, AR, CSNK2A1, CYP1B1, DRD2, DRD3, EGFR, F10, F3, GPR35, HSPA1A, HTR2A, HTR2B, HTR6, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, XDH 8.34106
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, ADRA1A, AKR1B1, ALOX15, AR, CSNK2A1, CYP1B1, DRD2, DRD3, DUSP3, EGFR, F10, F3, GPR35, HSPA1A, HTR2A, HTR2B, HTR6, IGF1R, INSR, KDR, MET, MMP9, NUAK1, SRC, TEK, XDH 8.30483
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, ALOX15, ALOX5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD2, EGFR, FABP3, FABP4, FUT7, HSD11B1, HSD17B1, MET, PPARA 7.77257
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, ADRA1A, AKR1B1, ALOX15, AR, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, F10, F3, GPR35, HCAR2, HSPA1A, HTR1A, HTR2A, HTR2B, HTR6, IGF1R, INSR, KDR, MET, MMP9, NUAK1, SMAD3, SRC, TEK, XDH 7.77257
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, ALOX15, AR, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, F10, F3, GPR35, HCAR2, HSPA1A, HTR1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MET, MMP9, PPARA, SMAD3, SRC, TEK 7.68837
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, ADRA1A, AKR1B1, ALOX15, AR, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, F10, F3, GPR35, HCAR2, HSPA1A, HTR1A, HTR2A, HTR2B, HTR6, IGF1R, INSR, KDR, MET, MMP9, NUAK1, SMAD3, SRC, TEK, XDH 7.65444
[BP] GO:0042221 response to chemical ADRA1A, AKR1B1, ALOX15, AR, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, EGFR, FABP3, FABP4, HSPA1A, HTR2A, HTR2B, HTR5A, IGF1R, INSR, KDR, MMP2, MMP9, NR3C1, PPARA, SMAD3, SRC, TEK 7.6099
[BP] GO:0010033 response to organic substance ADRA1A, AKR1B1, ALOX15, AR, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, EGFR, FABP3, FABP4, HSPA1A, HTR5A, IGF1R, INSR, KDR, MMP2, NR3C1, PPARA, SMAD3, SRC, TEK 7.53747
[BP] GO:0003018 None ADORA1, ADRA1A, DRD1, EGFR, HTR1A, HTR2A, HTR2B, HTR7, SRC, TEK 7.22175
[BP] GO:0007210 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 7.11586
[BP] GO:0098664 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 7.11586
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, ADRA1A, AKR1B1, ALOX15, AR, CA2, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, F10, F3, FABP3, GPR35, HCAR2, HSPA1A, HTR1A, HTR2A, HTR2B, HTR6, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NR3C1, PGR, PPARA, SMAD3, SRC, TEK, XDH 7.09608
[BP] GO:0009719 response to endogenous stimulus ADRA1A, AKR1B1, AR, CA2, CA9, CSNK2A1, CYP1A2, DRD1, EGFR, FABP3, HTR5A, IGF1R, INSR, MMP2, NR3C1, PPARA, SMAD3, SRC, TEK 6.91692
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, ADRA1A, AKR1B1, ALOX15, AR, CSNK2A1, CYP1B1, DRD2, DRD3, EGFR, F10, F3, FABP4, GPR35, HSPA1A, HTR2A, HTR2B, HTR6, INSR, KDR, MET, MMP2, MMP9, SMAD3, SRC, TEK, XDH 6.84177
[BP] GO:0019748 secondary metabolic process AKR1B1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6 6.79658
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 6.7705
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 6.74636
[BP] GO:0044281 small molecule metabolic process AKR1B1, ALOX15, ALOX5, CA1, CA12, CA2, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, FUT7, HSPA1A, HTR2B, PPARA, XDH 6.74156
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, AR, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, EGFR, FABP3, HTR5A, IGF1R, INSR, MMP2, MMP9, NR3C1, PPARA, SRC, TEK 6.72271
[BP] GO:0019369 arachidonic acid metabolic process ALOX15, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6 6.67086
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA5A, CA5B, CA6, CA7, CA9, DRD2, DRD3, FABP3, PPARA 6.41836
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 6.41836
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6 6.3695
[BP] GO:0003013 None ADORA1, ADRA1A, DRD1, EGFR, HTR1A, HTR2A, HTR2B, HTR7, SRC, TEK 6.27568
[BP] GO:2000021 regulation of ion homeostasis ADORA1, CA2, CA7, DRD1, DRD2, DRD3, HTR2A, HTR2B, KDR, SRC 6.22233
[BP] GO:0051896 regulation of protein kinase B signaling DRD2, DRD3, EGFR, F10, F3, INSR, MET, SRC, TEK, XDH 6.16978
[BP] GO:0006690 icosanoid metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6 6.16108
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, ADRA1A, AKR1B1, ALOX15, AR, CA2, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, F10, F3, FABP3, FABP4, GPR35, HCAR2, HSPA1A, HTR1A, HTR2A, HTR2B, HTR6, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NR3C1, PGR, PPARA, SMAD3, SRC, TEK, XDH 6.16108
[BP] GO:0009725 response to hormone ADRA1A, AKR1B1, AR, CA2, CA9, CSNK2A1, CYP1A2, EGFR, FABP3, HTR5A, INSR, NR3C1, PPARA, SRC, TEK 5.98335
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ADRA1A, ALOX15, AR, DRD1, DRD2, DRD3, DUSP3, EGFR, FABP3, FABP4, HTR2A, HTR2B, IGF1R, INSR, KDR, MMP9, NUAK1, PPARA, SMAD3, SRC, TEK, XDH 5.96768
[BP] GO:0097756 None ADORA1, ADRA1A, HTR1A, HTR2A, HTR2B, HTR7 5.96768
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 5.95853
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ADRA1A, ALOX15, AR, DRD1, DRD2, DRD3, DUSP3, EGFR, FABP3, FABP4, HTR2A, HTR2B, IGF1R, INSR, KDR, MMP9, NUAK1, PPARA, SMAD3, SRC, TEK, XDH 5.92083
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6, CYP2D6 5.90758
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6, CYP2D6 5.90758
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.67803
[BP] GO:0048878 chemical homeostasis ADRA1A, AKR1B1, CA12, CA2, CA7, DRD1, DRD2, DRD3, EGFR, FABP3, FABP4, GPR35, HTR2A, HTR2B, INSR, MET, SMAD3 5.64294
[BP] GO:0097746 None ADORA1, ADRA1A, DRD1, EGFR, HTR1A, HTR2A, HTR2B, HTR7 5.64294
[BP] GO:0035296 None ADORA1, ADRA1A, DRD1, EGFR, HTR1A, HTR2A, HTR2B, HTR7 5.64294
[BP] GO:0007187 None ADORA1, ADRA1A, DRD1, DRD2, DRD3, HTR1A, HTR5A, HTR6, HTR7 5.58281
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ADRA1A, ALOX15, AR, DRD2, DUSP3, EGFR, HTR2A, HTR2B, IGF1R, INSR, KDR, SRC, TEK, XDH 5.57373
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, DRD2, EGFR, HCAR2, HSD11B1, HSD17B1, HTR1A, HTR2A 5.56434
[BP] GO:0044255 cellular lipid metabolic process ACHE, ALOX15, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD2, EGFR, FABP3, FABP4, FUT7, MET, PPARA 5.55582
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ADRA1A, ALOX15, AR, DRD2, EGFR, HTR2A, HTR2B, INSR, KDR, SRC, TEK, XDH 5.5551
[BP] GO:0014070 response to organic cyclic compound AR, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, EGFR, HTR5A, NR3C1, SRC, TEK 5.54138
[BP] GO:0006939 None ADRA1A, DRD1, DRD2, HTR2A, HTR2B, HTR7 5.51689
[BP] GO:0050880 None ADORA1, ADRA1A, DRD1, EGFR, HTR1A, HTR2A, HTR2B, HTR7 5.49026
[BP] GO:0042493 response to drug ADRA1A, AKR1B1, CA9, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, FABP3, HTR2A, HTR2B, KDR, NR3C1, SRC 5.48309
[BP] GO:0035150 None ADORA1, ADRA1A, DRD1, EGFR, HTR1A, HTR2A, HTR2B, HTR7 5.47986
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade ADRA1A, ALOX15, DRD2, EGFR, HTR2A, HTR2B, KDR, SRC, TEK 5.37437
[BP] GO:0030335 positive regulation of cell migration DRD1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 5.31791
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, AR, CSNK2A1, DRD2, DRD3, EGFR, F3, HTR1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MMP2, MMP9, TEK 5.29874
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ADRA1A, ALOX15, DRD2, DUSP3, EGFR, HTR2A, HTR2B, KDR, SRC, TEK 5.2912
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA5A, CA5B, CA6, CA7, CA9, DRD2, DRD3, FABP3, PPARA 5.28953
[BP] GO:0032501 multicellular organismal process ADORA1, ADRA1A, AKR1B1, ALOX15, ALOX5, AR, CYP19A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, F10, F3, FABP4, HTR1A, HTR2A, HTR2B, HTR7, IGF1R, INSR, MET, MMP1, MMP2, MMP9, PPARA, SMAD3, SRC, TEK 5.2832
[BP] GO:2000147 positive regulation of cell motility DRD1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 5.18037
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, CA2, CYP1A1, CYP1A2, CYP1B1, DRD2, EGFR, FABP4, KDR, MMP9, SRC 5.14334
[BP] GO:0007165 signal transduction ADORA1, ADORA3, ADRA1A, AKR1B1, AR, CA1, CA2, CSNK2A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, F3, GPR35, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PPARA, SIGMAR1, SMAD3, SRC, TEK 5.13623
[BP] GO:0042310 None ADRA1A, HTR1A, HTR2A, HTR2B, HTR7 5.08192
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX15, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6 5.07179
[BP] GO:0051272 positive regulation of cellular component movement DRD1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 5.06883
[BP] GO:1901568 fatty acid derivative metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6 5.03762
[BP] GO:0032844 regulation of homeostatic process ADORA1, CA2, CA7, DRD1, DRD2, DRD3, EGFR, HCAR2, HTR2A, HTR2B, KDR, SRC 5.03706
[BP] GO:0006631 fatty acid metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, PPARA 5.03226
[BP] GO:0007188 None ADORA1, ADRA1A, DRD1, DRD2, DRD3, HTR1A, HTR5A, HTR7 5.02835
[BP] GO:0042592 homeostatic process ADORA1, ADRA1A, AKR1B1, CA12, CA2, CA7, DRD1, DRD2, DRD3, EGFR, FABP3, FABP4, GPR35, HTR2A, HTR2B, INSR, MET, SMAD3, SRC 5.00715
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, ADRA1A, CA2, CA7, DRD1, DRD2, DRD3, EGFR, HTR2A 4.9802
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, ADRA1A, CA2, CA7, DRD1, DRD2, DRD3, EGFR, HTR2A 4.9802
[BP] GO:0040017 positive regulation of locomotion DRD1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 4.93727
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, ADRA1A, CA2, CA7, DRD2 4.90896
[BP] GO:0050795 None ADORA1, DRD2, DRD3, HTR1A, HTR2A, HTR2B 4.89187
[BP] GO:0048583 regulation of response to stimulus ADORA1, ADRA1A, AKR1B1, ALOX15, AR, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, F10, F3, FABP4, GPR35, HSPA1A, HTR2A, HTR2B, HTR6, IGF1R, INSR, KDR, MET, MMP2, MMP9, NUAK1, PPARA, SMAD3, SRC, TEK, XDH 4.88656
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ADRA1A, ALOX15, AR, DRD1, DRD2, EGFR, FABP3, HTR2A, HTR2B, INSR, KDR, MMP9, SMAD3, SRC, TEK, XDH 4.87773
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ADRA1A, ALOX15, AR, DRD1, DRD2, EGFR, FABP3, HTR2A, HTR2B, INSR, KDR, MMP9, SMAD3, SRC, TEK, XDH 4.87773
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, ALOX15, ALOX5, AR, CA1, CA12, CA2, CA5A, CA5B, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, F10, F3, FABP3, FABP4, FUT7, HSD11B1, HSD17B1, HSPA1A, HTR1A, HTR2B, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PPARA, SMAD3, SRC, TEK, XDH 4.69858
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, ADRA1A, AR, DRD1, DRD2, DRD3, DUSP3, EGFR, GPR35, HSPA1A, HTR2A, IGF1R, MET, MMP9, SMAD3, SRC, XDH 4.69124
[BP] GO:0008202 steroid metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, HSD11B1, HSD17B1 4.6835
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, ADRA1A, AR, DRD1, DRD2, DRD3, DUSP3, EGFR, GPR35, HSPA1A, HTR2A, IGF1R, MET, MMP9, SMAD3, SRC, XDH 4.6835
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, CA2, CYP1A1, DRD1, DRD2, DRD3, EGFR, HSPA1A, HTR2A, HTR2B, MMP2, PPARA, SMAD3, SRC, TEK 4.6835
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA1, ADORA3, ADRA1A, CA2, DRD1, DRD2, DRD3, GPR35, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, INSR, SIGMAR1, SRC 4.6835
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, ALOX15, AR, CA2, CA6, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, EGFR, F10, F3, FABP3, FABP4, HSPA1A, HTR1A, HTR2A, HTR2B, HTR5A, IGF1R, INSR, KDR, MMP2, MMP9, NR3C1, NUAK1, PPARA, SMAD3, SRC, TEK 4.64986
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, CYP1A1, DRD2, EGFR, PPARA, SMAD3 4.64794
[BP] GO:0009966 regulation of signal transduction ADORA1, ADRA1A, AKR1B1, ALOX15, AR, CSNK2A1, CYP1B1, DRD2, DRD3, DUSP3, EGFR, F10, F3, GPR35, HSPA1A, HTR2A, HTR2B, HTR6, IGF1R, INSR, KDR, MET, MMP9, NUAK1, SMAD3, SRC, TEK, XDH 4.64704
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, EGFR, HSPA1A 4.63805
[BP] GO:0007198 None HTR1A, HTR5A, HTR7 4.63805
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, ADRA1A, CA2, CA7, DRD1, DRD2, EGFR 4.61566
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, DRD1, DRD2, DRD3, EGFR, HTR1A, INSR, SMAD3 4.59645
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AR, CSNK2A1, CYP1B1, EGFR, F3, HCAR2, HSPA1A, HTR2B, IGF1R, KDR, MET, MMP9, PPARA, SIGMAR1, SMAD3, SRC, TEK, XDH 4.53759
[BP] GO:0007193 None ADORA1, DRD2, DRD3, HTR1A, HTR5A, HTR7 4.51395
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ADRA1A, ALOX15, AR, CYP19A1, DRD1, DRD2, DRD3, DUSP3, EGFR, HSPA1A, IGF1R, MET, MMP9, PPARA, SMAD3, SRC, TEK, XDH 4.50667
[BP] GO:0042325 regulation of phosphorylation ADORA1, ADRA1A, ALOX15, AR, DRD1, DRD2, DUSP3, EGFR, FABP4, HTR2A, HTR2B, IGF1R, INSR, KDR, MMP9, PPARA, SRC, TEK, XDH 4.42866
[BP] GO:0050801 ion homeostasis ADRA1A, CA12, CA2, CA7, DRD1, DRD2, DRD3, EGFR, FABP3, GPR35, HTR2A, HTR2B, SMAD3 4.4226
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AR, CSNK2A1, CYP1B1, EGFR, F3, HCAR2, HSPA1A, HTR2B, IGF1R, KDR, MET, MMP9, SIGMAR1, SMAD3, SRC, TEK, XDH 4.36691
[BP] GO:0051049 regulation of transport ACHE, ADORA1, ALOX15, CA2, CA7, CYP19A1, DRD1, DRD2, DRD3, EGFR, GPR35, HCAR2, HSPA1A, HTR1A, HTR2A, HTR2B, INSR, MMP9, PPARA, SMAD3, SRC 4.35647
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, HTR2A, HTR2B, SRC, TEK 4.3425
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CYP1A1, DRD3, FABP3, HCAR2, HTR2A, HTR2B, PPARA, SRC, TEK 4.3425
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ADRA1A, ALOX15, AR, DRD1, DRD2, DUSP3, EGFR, FABP4, HTR2A, HTR2B, IGF1R, INSR, KDR, MMP9, SRC, TEK, XDH 4.30052
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AR, CSNK2A1, EGFR, HSPA1A, HTR2B, IGF1R, KDR, MET, MMP9, PPARA, SMAD3, SRC, TEK 4.25145
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 4.15799
[BP] GO:0048148 None DRD1, DRD2, DRD3, HTR2A 4.12751
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, ADRA1A, AR, CSNK2A1, DRD1, DRD2, DRD3, DUSP3, EGFR, F3, FABP4, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, MMP9, NUAK1, SMAD3, SRC, TEK, XDH 4.09434
[BP] GO:0008217 None ADORA1, ADRA1A, AR, DRD2, DRD3, PPARA, SMAD3 4.06095
[BP] GO:0031399 regulation of protein modification process ADORA1, ADRA1A, ALOX15, AR, DRD1, DRD2, DUSP3, EGFR, FABP4, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MMP9, NUAK1, SRC, TEK, XDH 4.05851
[BP] GO:0051897 positive regulation of protein kinase B signaling EGFR, F10, F3, INSR, MET, SRC, TEK 4.01096
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AR, CSNK2A1, EGFR, HSPA1A, HTR2B, IGF1R, KDR, MET, MMP9, SMAD3, SRC, TEK 3.9767
[BP] GO:0006811 None ADRA1A, CA1, CA12, CA14, CA2, CA5A, CA5B, CA6, CA7, CA9, DRD1, DRD2, DRD3, FABP3, HTR2A, HTR2B, PPARA 3.97441
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, ADRA1A, AR, CSNK2A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, F3, FABP4, GPR35, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, MET, MMP9, NUAK1, PPARA, SMAD3, SRC, TEK, XDH 3.95835
[BP] GO:0051701 interaction with host EGFR, HSPA1A, HTR2A, INSR, MET, SMAD3, SRC 3.91145
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, ALOX15, ALOX5, AR, CA1, CA12, CA2, CA5A, CA5B, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, F10, FABP3, FABP4, FUT7, HSD17B1, HSPA1A, HTR1A, HTR2B, IGF1R, INSR, KDR, MET, MMP1, MMP2, NR3C1, NR3C2, NUAK1, PGR, PPARA, SMAD3, SRC, TEK, XDH 3.90995
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALOX15, AR, CYP1A1, CYP1A2, CYP1B1, DRD1, EGFR, FABP4, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NR3C1, SMAD3, SRC 3.88147
[BP] GO:0019932 second-messenger-mediated signaling ADRA1A, DRD1, DRD2, DRD3, EGFR, HTR2B, HTR5A, KDR 3.85353
[BP] GO:0007202 None ADRA1A, EGFR, HTR2A, HTR2B 3.83241
[BP] GO:0098771 inorganic ion homeostasis ADRA1A, CA12, CA2, CA7, DRD1, DRD2, DRD3, EGFR, GPR35, HTR2A, HTR2B, SMAD3 3.82814
[BP] GO:0048513 animal organ development ACHE, ADRA1A, AR, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, HSD11B1, INSR, KDR, PPARA, SMAD3, SRC, TEK 3.82398
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AR, CSNK2A1, CYP1B1, EGFR, F3, HCAR2, HSPA1A, HTR2B, IGF1R, KDR, MMP9, SIGMAR1, SMAD3, SRC, TEK, XDH 3.81068
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, ADRA1A, AKR1B1, ALOX15, AR, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, EGFR, HSD11B1, HTR5A, INSR, KDR, MMP9, PGR, PPARA, SIGMAR1, SMAD3, SRC, TEK 3.7885
[BP] GO:0050678 None AR, EGFR, F3, HTR2B, KDR, PGR, SMAD3, TEK, XDH 3.76507
[BP] GO:0032502 developmental process ACHE, ADORA1, ADRA1A, AKR1B1, ALOX15, AR, CA2, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, EGFR, FABP4, FUT7, HSD11B1, HTR2A, HTR2B, HTR5A, INSR, KDR, MET, MMP2, MMP9, PGR, PPARA, SIGMAR1, SMAD3, SRC, TEK 3.76507
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, DRD1, DRD2, DRD3, EGFR, F3, FABP4, KDR, MET, PPARA, SMAD3, TEK 3.73646
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, DRD1, DRD2, EGFR, HTR2A 3.72827
[BP] GO:0051240 positive regulation of multicellular organismal process ADRA1A, AR, CA2, CYP1B1, DRD2, DRD3, EGFR, F3, HCAR2, HSPA1A, HTR2A, HTR2B, KDR, MET, MMP9, SMAD3, SRC, TEK 3.70923
[BP] GO:0051940 None DRD1, DRD2, DRD3 3.62429
[BP] GO:0051584 None DRD1, DRD2, DRD3 3.62429
[BP] GO:1901654 None AKR1B1, AR, CA9, CSNK2A1, EGFR, NR3C1, SRC 3.60878
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ADRA1A, ALOX15, AR, DRD2, EGFR, HTR2A, HTR2B, INSR, KDR, MMP9, SRC, TEK, XDH 3.59347
[BP] GO:0001666 response to hypoxia ADORA1, CYP1A1, DRD2, MMP2, PPARA, SMAD3, SRC, TEK 3.57843
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, DRD1, DRD2, HTR2A 3.57018
[BP] GO:0097164 None ACHE, AKR1B1, CSNK2A1, DRD1, DRD2, DRD3, HTR1A 3.55666
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, DRD1, DRD2, HTR2A, MET 3.51486
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD11B1, HSD17B1 3.51425
[BP] GO:0018108 peptidyl-tyrosine phosphorylation EGFR, IGF1R, INSR, KDR, MET, SRC, TEK 3.50106
[BP] GO:0036293 response to decreased oxygen levels ADORA1, CYP1A1, DRD2, MMP2, PPARA, SMAD3, SRC, TEK 3.49696
[BP] GO:0071073 None FABP3, HTR2A, HTR2B 3.47787
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ADRA1A, ALOX15, AR, CSNK2A1, DRD1, DRD2, DRD3, EGFR, F3, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MET, MMP9, NR3C1, PGR, PPARA, SMAD3, SRC, TEK, XDH 3.46895
[BP] GO:0018212 peptidyl-tyrosine modification EGFR, IGF1R, INSR, KDR, MET, SRC, TEK 3.46658
[BP] GO:0001659 None ADORA1, DRD1, DRD2, HTR2A 3.4347
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, HTR2A, HTR2B, PPARA, SRC, TEK 3.43085
[BP] GO:0090066 None ADORA1, ADRA1A, ALOX15, DRD1, EGFR, HTR1A, HTR2A, HTR2B, HTR7 3.42286
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ADRA1A, ALOX15, AR, CSNK2A1, DRD2, EGFR, F3, HSPA1A, HTR2A, HTR2B, INSR, KDR, MMP9, SMAD3, SRC, TEK, XDH 3.42286
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ADRA1A, ALOX15, AR, DRD2, EGFR, HTR2A, HTR2B, INSR, KDR, MMP9, SRC, TEK, XDH 3.40862
[BP] GO:0032787 None ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, PPARA 3.39143
[BP] GO:0022029 None DRD1, DRD2, EGFR, HTR6 3.39122
[BP] GO:0080134 regulation of response to stress ADORA1, CYP19A1, DRD2, DUSP3, EGFR, F3, FABP4, HSPA1A, IGF1R, MET, MMP2, NUAK1, PPARA, SMAD3, SRC, TEK, XDH 3.3865
[BP] GO:0032102 negative regulation of response to external stimulus ADORA1, CYP19A1, DRD1, DRD2, DRD3, PPARA, SMAD3, TEK 3.3865
[BP] GO:0046777 protein autophosphorylation CSNK2A1, EGFR, IGF1R, INSR, KDR, SRC, TEK 3.3865
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AR, CSNK2A1, EGFR, HSPA1A, HTR2B, IGF1R, KDR, MMP9, SMAD3, SRC, TEK 3.3865
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, HTR2A, HTR2B, SRC, TEK 3.36575
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.35947
[BP] GO:0010863 positive regulation of phospholipase C activity ADRA1A, EGFR, HTR2A, HTR2B 3.35347
[BP] GO:0048511 rhythmic process CSNK2A1, DRD2, DRD3, EGFR, HTR7, PGR, PPARA, SRC 3.3432
[BP] GO:0051047 None ACHE, ADORA1, CYP19A1, DRD2, DRD3, EGFR, HCAR2, HTR2B, SRC 3.33051
[BP] GO:0043401 steroid hormone mediated signaling pathway AR, NR3C1, NR3C2, PGR, PPARA, SRC 3.32627
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, ALOX15, AR, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, FABP3, FABP4, GPR35, HCAR2, HSPA1A, HTR2A, HTR2B, IGF1R, KDR, MET, MMP9, NR3C1, PGR, PPARA, SMAD3, SRC, TEK, XDH 3.29504
[BP] GO:0070482 response to oxygen levels ADORA1, CYP1A1, DRD2, MMP2, PPARA, SMAD3, SRC, TEK 3.27585
[BP] GO:0051952 None ADORA1, DRD1, DRD2, DRD3, HTR2A 3.26829
[BP] GO:0021885 forebrain cell migration DRD1, DRD2, EGFR, HTR6 3.26519
[BP] GO:0002031 None DRD2, DRD3, HTR2B 3.24298
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ADRA1A, ALOX15, AR, DRD1, DRD2, DRD3, EGFR, F3, FABP3, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MET, MMP9, NR3C1, PGR, PPARA, SMAD3, SRC, TEK, XDH 3.22628
[BP] GO:1900274 regulation of phospholipase C activity ADRA1A, EGFR, HTR2A, HTR2B 3.22269
[BP] GO:0018958 None AKR1B1, DRD1, DRD2, DRD3, HTR1A 3.22269
[BP] GO:0007267 None ADORA1, ADRA1A, AR, DRD1, DRD2, DRD3, HTR2A, HTR6, HTR7, PGR, TEK 3.22146
[BP] GO:0055080 cation homeostasis ADRA1A, CA2, CA7, DRD1, DRD2, DRD3, EGFR, GPR35, HTR2A, HTR2B, SMAD3 3.21034
[BP] GO:0055114 oxidation-reduction process AKR1B1, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, HSD11B1, HSD17B1, XDH 3.2051
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ADRA1A, ALOX15, AR, CSNK2A1, DRD1, DRD2, DRD3, EGFR, F3, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MET, MMP9, NR3C1, PGR, PPARA, SMAD3, SRC, TEK, XDH 3.19686
[BP] GO:0010243 response to organonitrogen compound AKR1B1, DRD1, DRD2, DRD3, EGFR, FABP3, IGF1R, INSR, MMP2, PPARA, SRC, TEK 3.19651
[BP] GO:0035556 intracellular signal transduction ADRA1A, AKR1B1, CYP1B1, DRD1, DRD2, DRD3, EGFR, HTR2A, HTR2B, HTR5A, IGF1R, INSR, KDR, MET, NUAK1, SRC, TEK 3.18495
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, ADRA1A, ALOX15, AR, DRD2, EGFR, F3, HSPA1A, HTR2A, HTR2B, INSR, KDR, MMP9, SMAD3, SRC, TEK, XDH 3.17179
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ADRA1A, ALOX15, AR, CSNK2A1, DRD1, DRD2, DRD3, EGFR, F3, FABP3, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MET, MMP9, NR3C1, PGR, PPARA, SMAD3, SRC, TEK, XDH 3.16687
[BP] GO:1902532 negative regulation of intracellular signal transduction ADRA1A, DRD2, DRD3, DUSP3, HSPA1A, IGF1R, MET, MMP9, SRC, XDH 3.16277
[BP] GO:1901655 None AKR1B1, AR, EGFR, NR3C1, SRC 3.16277
[BP] GO:0043271 negative regulation of ion transport ADORA1, DRD2, DRD3, GPR35, HTR2A, MMP9 3.16277
[BP] GO:0044057 None ADORA1, ADORA3, ADRA1A, DRD2, DRD3, EGFR, GPR35, HCAR2, HTR2A, SMAD3 3.15225
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALOX15, AR, CYP1A1, CYP1B1, DRD1, EGFR, FABP4, IGF1R, INSR, KDR, MMP2, NR3C1, SMAD3, SRC 3.12775
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, ALOX15, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, HTR1A 3.09832
[BP] GO:0032268 regulation of cellular protein metabolic process ADORA1, ADRA1A, ALOX15, AR, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, F3, FABP4, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MMP9, NUAK1, SMAD3, SRC, TEK, XDH 3.09802
[BP] GO:0072507 divalent inorganic cation homeostasis ADRA1A, DRD1, DRD2, DRD3, EGFR, GPR35, HTR2A, HTR2B, SMAD3 3.06859
[BP] GO:0071248 cellular response to metal ion ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9 3.05595
[BP] GO:0032846 positive regulation of homeostatic process CA2, CA7, DRD1, DRD2, DRD3, EGFR, HCAR2 3.05595
[BP] GO:0060134 None DRD1, DRD2, DRD3 3.05595
[BP] GO:0032230 positive regulation of synaptic transmission, GABAergic ADRA1A, CA2, CA7 3.05595
[BP] GO:0010038 response to metal ion ALOX15, CA2, CYP1A1, CYP1A2, DRD2, EGFR, FABP4, MMP9 3.04217
[BP] GO:0007200 None ADRA1A, DRD1, DRD2, HTR2A, HTR2B 3.03689
[BP] GO:0045776 None ADORA1, DRD2, DRD3, PPARA 3.0018
[BP] GO:2001023 None DRD1, DRD2, DRD3, HTR2A, MET 2.99393
[BP] GO:0006584 None AKR1B1, DRD1, DRD2, DRD3 2.96824
[BP] GO:0009712 None AKR1B1, DRD1, DRD2, DRD3 2.96824
[BP] GO:0051580 None DRD1, DRD2, DRD3 2.96824
[BP] GO:0051967 None ADORA1, DRD2, HTR2A 2.96824
[BP] GO:0019933 None ADRA1A, DRD1, DRD2, DRD3, HTR5A 2.95728
[BP] GO:1903530 regulation of secretion by cell ACHE, ADORA1, CYP19A1, DRD2, DRD3, EGFR, HCAR2, HTR1A, HTR2A, HTR2B, SRC 2.93494
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, CA2, CYP19A1, DRD1, DRD2, DRD3, EGFR, HCAR2, HTR2B, INSR, SMAD3, SRC 2.92582
[BP] GO:1901698 response to nitrogen compound AKR1B1, DRD1, DRD2, DRD3, EGFR, FABP3, IGF1R, INSR, MMP2, PPARA, SRC, TEK 2.9184
[BP] GO:0001963 None DRD1, DRD2, DRD3 2.88269
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, DUSP3, EGFR, HTR2A, HTR2B, IGF1R, INSR, SRC 2.86871
[BP] GO:0030003 cellular cation homeostasis ADRA1A, CA2, CA7, DRD1, DRD2, DRD3, GPR35, HTR2A, HTR2B, SMAD3 2.86871
[BP] GO:0016477 cell migration CYP1B1, DRD1, DRD2, EGFR, FUT7, HTR2B, HTR6, KDR, MMP1, MMP9, SRC, TEK 2.85492
[BP] GO:0023052 None ADORA1, ADRA1A, AR, DRD1, DRD2, DRD3, HTR2A, HTR6, HTR7, PGR, TEK 2.85492
[BP] GO:0009056 catabolic process ACHE, ADORA1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, FABP3, FABP4, FUT7, HSPA1A, MMP1, MMP2, MMP9, SRC, XDH 2.80714
[BP] GO:0071071 None FABP3, HTR2A, HTR2B 2.80714
[BP] GO:0032225 None DRD1, DRD2, DRD3 2.80714
[BP] GO:0009755 hormone-mediated signaling pathway AR, NR3C1, NR3C2, PGR, PPARA, SRC 2.80714
[BP] GO:0006873 cellular ion homeostasis ADRA1A, CA2, CA7, DRD1, DRD2, DRD3, GPR35, HTR2A, HTR2B, SMAD3 2.79093
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, AR, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, FABP3, FABP4, GPR35, HSPA1A, HTR2A, HTR2B, IGF1R, KDR, MET, MMP9, NR3C1, PPARA, SMAD3, SRC, TEK, XDH 2.78639
[BP] GO:0019935 None ADRA1A, DRD1, DRD2, DRD3, HTR5A 2.78483
[BP] GO:0010518 positive regulation of phospholipase activity ADRA1A, EGFR, HTR2A, HTR2B 2.77353
[BP] GO:0002793 None ACHE, ADORA1, DRD2, EGFR, HCAR2, HTR2B, SRC 2.77353
[BP] GO:0051828 entry into other organism involved in symbiotic interaction EGFR, HSPA1A, HTR2A, MET, SRC 2.77353
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction EGFR, HSPA1A, HTR2A, MET, SRC 2.77353
[BP] GO:0030260 entry into host cell EGFR, HSPA1A, HTR2A, MET, SRC 2.77353
[BP] GO:0044409 entry into host EGFR, HSPA1A, HTR2A, MET, SRC 2.77353
[BP] GO:0031348 negative regulation of defense response ADORA1, CYP19A1, DRD2, PPARA, SMAD3, TEK 2.76515
[BP] GO:0071241 cellular response to inorganic substance ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9 2.75243
[BP] GO:0033993 response to lipid AR, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, EGFR, FABP3, HTR5A, NR3C1, SRC 2.75075
[BP] GO:0044092 negative regulation of molecular function ADORA3, CSNK2A1, CYP1B1, CYP2D6, DRD2, DRD3, DUSP3, FABP4, GPR35, IGF1R, MET, MMP9, PPARA, SRC 2.74594
[BP] GO:0051130 positive regulation of cellular component organization ALOX15, AR, DRD2, DRD3, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, SMAD3, SRC, TEK 2.72691
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ADRA1A, AR, CA2, CYP1B1, DRD2, DRD3, EGFR, F3, GPR35, HCAR2, HSPA1A, HTR2A, HTR2B, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, XDH 2.72646
[BP] GO:0051234 None ACHE, ADORA1, ADRA1A, ALOX15, ALOX5, AR, CA1, CA12, CA14, CA2, CA5A, CA5B, CA6, CA7, CA9, DRD1, DRD2, DRD3, EGFR, F10, FABP3, HSPA1A, HTR2A, HTR2B, MMP9, PPARA, SIGMAR1, SRC, XDH 2.72227
[BP] GO:0050679 None AR, EGFR, F3, HTR2B, KDR, TEK 2.71943
[BP] GO:0009895 negative regulation of catabolic process ADORA1, EGFR, HCAR2, HTR2B, MET, PPARA, SMAD3 2.70599
[BP] GO:0046883 regulation of hormone secretion ADORA1, CYP19A1, DRD2, EGFR, HCAR2, HTR1A, HTR2A 2.70599
[BP] GO:0040011 locomotion CYP1B1, DRD1, DRD2, EGFR, FUT7, HTR2B, HTR6, KDR, MET, MMP1, MMP9, SRC, TEK 2.69849
[BP] GO:0003012 None ADORA1, ADRA1A, DRD1, DRD2, HTR2A, HTR2B, HTR7 2.69849
[BP] GO:0051046 None ACHE, ADORA1, CYP19A1, DRD2, DRD3, EGFR, HCAR2, HTR1A, HTR2A, HTR2B, SRC 2.69639
[BP] GO:0014821 None DRD1, DRD2, HTR2B 2.68495
[BP] GO:0006721 terpenoid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2D6, EGFR 2.67709
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1 2.66061
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, CYP1B1, EGFR, MMP9, SRC 2.66061
[BP] GO:0043269 regulation of ion transport ADORA1, CA2, CA7, DRD1, DRD2, DRD3, GPR35, HTR1A, HTR2A, MMP9 2.65848
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.64585
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.64585
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ADRA1A, ALOX15, AR, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, F3, FABP3, FABP4, HCAR2, HSPA1A, HTR1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MET, MMP9, NR3C1, NR3C2, NUAK1, PGR, PPARA, SMAD3, SRC, TEK, XDH 2.64585
[BP] GO:0050890 None ADORA1, DRD1, DRD2, DRD3, EGFR, HTR2A, INSR 2.63062
[BP] GO:0060748 None AR, PGR 2.62951
[BP] GO:0060160 None DRD2, DRD3 2.62951
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.62951
[BP] GO:0045187 None ADORA1, DRD2, DRD3 2.62951
[BP] GO:0010638 positive regulation of organelle organization ALOX15, DRD3, HSPA1A, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 2.62951
[BP] GO:0051246 regulation of protein metabolic process ADORA1, ADRA1A, ALOX15, AR, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, F3, FABP4, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MMP9, NUAK1, SMAD3, SRC, TEK, XDH 2.62607
[BP] GO:0031623 None ACHE, DRD2, DRD3, HTR2B 2.62599
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ADRA1A, ALOX15, AR, DRD2, EGFR, HTR2A, HTR2B, INSR, KDR, MMP9, SRC, TEK, XDH 2.61677
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, AR, CYP1B1, DRD1, EGFR, IGF1R, INSR, MMP2, MMP9, NR3C1, SRC 2.61601
[BP] GO:0006874 cellular calcium ion homeostasis ADRA1A, DRD1, DRD2, DRD3, GPR35, HTR2A, HTR2B, SMAD3 2.59228
[BP] GO:0003008 None ADORA1, ADRA1A, AKR1B1, CYP1B1, DRD1, DRD2, DRD3, EGFR, HTR1A, HTR2A, HTR2B, HTR7, INSR, SRC, TEK 2.58155
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway EGFR, IGF1R, INSR, KDR, MET, MMP2, MMP9, SRC, TEK 2.5805
[BP] GO:0001503 ossification ALOX15, EGFR, MMP2, MMP9, TEK 2.57795
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6 2.57795
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.57795
[BP] GO:0035813 None ADORA1, DRD2, DRD3 2.57795
[BP] GO:0050728 negative regulation of inflammatory response ADORA1, CYP19A1, PPARA, SMAD3, TEK 2.56248
[BP] GO:0002009 morphogenesis of an epithelium AR, CA2, CA9, EGFR, MET, SMAD3, SRC 2.55928
[BP] GO:0035690 cellular response to drug AKR1B1, CYP1B1, DRD1, EGFR, KDR, NR3C1, SRC 2.55928
[BP] GO:0009894 regulation of catabolic process ADORA1, CSNK2A1, EGFR, HCAR2, HSPA1A, HTR2A, HTR2B, INSR, KDR, MET, PPARA, SMAD3 2.55172
[BP] GO:0048870 cell motility CYP1B1, DRD1, DRD2, EGFR, FUT7, HTR2B, HTR6, KDR, MMP1, MMP9, SRC, TEK 2.5393
[BP] GO:0051480 regulation of cytosolic calcium ion concentration ADRA1A, DRD1, DRD2, GPR35, HTR2A, HTR2B, SMAD3 2.5356
[BP] GO:0006810 None ACHE, ADORA1, ADRA1A, ALOX15, ALOX5, AR, CA1, CA12, CA14, CA2, CA5A, CA5B, CA6, CA7, CA9, DRD1, DRD2, DRD3, F10, FABP3, HSPA1A, HTR2A, HTR2B, MMP9, PPARA, SIGMAR1, SRC, XDH 2.53306
[BP] GO:0010517 regulation of phospholipase activity ADRA1A, EGFR, HTR2A, HTR2B 2.5314
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, CYP1B1, EGFR, HSPA1A, MMP9, SRC 2.52885
[BP] GO:0042749 None ADORA1, DRD2, DRD3 2.52703
[BP] GO:0055074 calcium ion homeostasis ADRA1A, DRD1, DRD2, DRD3, GPR35, HTR2A, HTR2B, SMAD3 2.52322
[BP] GO:0065007 biological regulation ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, ALOX15, AR, CA1, CA12, CA2, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, F10, F3, FABP3, FABP4, GPR35, HCAR2, HSD11B1, HSD17B1, HSPA1A, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PPARA, SIGMAR1, SMAD3, SRC, TEK, XDH 2.51932
[BP] GO:0072503 cellular divalent inorganic cation homeostasis ADRA1A, DRD1, DRD2, DRD3, GPR35, HTR2A, HTR2B, SMAD3 2.48719
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD17B1 2.48216
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, DRD2, EGFR, FABP4, HSPA1A, MMP2, PPARA, SMAD3, SRC, TEK 2.47508
[BP] GO:0009636 response to toxic substance AKR1B1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, KDR, SRC 2.46192
[BP] GO:0060193 positive regulation of lipase activity ADRA1A, EGFR, HTR2A, HTR2B 2.45953
[BP] GO:0055082 cellular chemical homeostasis ADRA1A, CA2, CA7, DRD1, DRD2, DRD3, GPR35, HTR2A, HTR2B, SMAD3 2.45547
[BP] GO:0046486 glycerolipid metabolic process ACHE, ALOX15, CSNK2A1, DRD2, EGFR, FABP3, FABP4, MET 2.45329
[BP] GO:0044062 None ADORA1, DRD2, DRD3 2.4239
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.4239
[BP] GO:0006720 isoprenoid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2D6, EGFR 2.4239
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, SRC, TEK 2.4239
[BP] GO:0009891 positive regulation of biosynthetic process AR, DRD1, DRD2, DRD3, EGFR, FABP3, HTR2A, HTR2B, IGF1R, INSR, KDR, MET, NR3C1, PGR, PPARA, SMAD3, SRC 2.41995
[BP] GO:0060402 None ADRA1A, DRD2, HTR2A, HTR2B 2.41806
[BP] GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process CSNK2A1, F3, MMP9, SMAD3, SRC, XDH 2.40996
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.38986
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.38986
[BP] GO:0051894 None KDR, SMAD3, TEK 2.37879
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1 2.37879
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.37879
[BP] GO:0007610 None DRD1, DRD2, DRD3, EGFR, HTR1A, HTR2A, HTR2B, INSR, PPARA 2.36985
[BP] GO:0007167 enzyme linked receptor protein signaling pathway EGFR, IGF1R, INSR, KDR, MET, MMP2, MMP9, SMAD3, SRC, TEK 2.36116
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALOX15, AR, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, EGFR, FABP4, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NR3C1, NUAK1, SMAD3, SRC 2.35759
[BP] GO:0015908 None DRD2, DRD3, FABP3, PPARA 2.35357
[BP] GO:0055065 metal ion homeostasis ADRA1A, DRD1, DRD2, DRD3, EGFR, GPR35, HTR2A, HTR2B, SMAD3 2.34536
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, ADRA1A, ALOX15, AR, CA9, CSNK2A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, F3, FABP3, FABP4, HCAR2, HSPA1A, HTR1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MET, MMP9, NR3C1, NR3C2, NUAK1, PGR, PPARA, SMAD3, SRC, TEK, XDH 2.33541
[BP] GO:0006936 None ADRA1A, DRD1, DRD2, HTR2A, HTR2B, HTR7 2.33539
[BP] GO:0050927 None F3, KDR, SMAD3 2.33539
[BP] GO:0045913 None HTR2A, INSR, PPARA, SRC 2.33442
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, AR, DRD1, EGFR, IGF1R, INSR, MMP2, NR3C1, SMAD3, SRC 2.32439
[BP] GO:0001936 None F3, HTR2B, KDR, TEK, XDH 2.3207
[BP] GO:0050926 None F3, KDR, SMAD3 2.29146
[BP] GO:1903393 None KDR, SMAD3, TEK 2.29146
[BP] GO:0001975 None DRD1, DRD2, DRD3 2.29146
[BP] GO:0007623 circadian rhythm DRD2, DRD3, EGFR, HTR7, PPARA 2.28083
[BP] GO:0007189 None ADRA1A, DRD1, DRD2, DRD3 2.24801
[BP] GO:0008285 negative regulation of cell proliferation ADORA1, ADORA3, ADRA1A, AR, CYP1B1, DRD2, FABP3, HSPA1A, SMAD3, XDH 2.23161
[BP] GO:0043549 regulation of kinase activity ADORA1, DRD2, DUSP3, EGFR, FABP4, HTR2A, HTR2B, IGF1R, INSR, SRC, TEK 2.23064
[BP] GO:0030534 None DRD1, DRD2, DRD3, HTR2A, PPARA 2.22727
[BP] GO:0071383 None AR, EGFR, NR3C1, SRC 2.21205
[BP] GO:0042417 None DRD1, DRD2, DRD3 2.21205
[BP] GO:0014059 None DRD2, DRD3, HTR2A 2.21205
[BP] GO:0021853 None DRD1, DRD2 2.21205
[BP] GO:0010641 None F3, SRC 2.21205
[BP] GO:0090325 None DRD2, DRD3 2.21205
[BP] GO:0007598 None F10, F3 2.21205
[BP] GO:1904936 None DRD1, DRD2 2.21205
[BP] GO:0042321 None ADORA1, DRD2 2.21205
[BP] GO:0010513 None HTR2A, HTR2B 2.21205
[BP] GO:0032413 None DRD2, DRD3, GPR35, MMP9 2.19623
[BP] GO:0032845 None ADORA1, DRD2, HTR2A, HTR2B, SRC 2.18462
[BP] GO:0050794 regulation of cellular process ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, ALOX15, AR, CA1, CA2, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, F10, F3, FABP3, FABP4, GPR35, HCAR2, HSPA1A, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PPARA, SIGMAR1, SMAD3, SRC, TEK, XDH 2.18227
[BP] GO:0009968 negative regulation of signal transduction ADRA1A, AR, DRD2, DRD3, DUSP3, EGFR, HSPA1A, IGF1R, MET, MMP9, SMAD3, SRC, XDH 2.17947
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9 2.17947
[BP] GO:0060401 None ADRA1A, DRD2, HTR2A, HTR2B 2.17947
[BP] GO:0002791 None ACHE, ADORA1, DRD2, DRD3, EGFR, HCAR2, HTR2B, SRC 2.17654
[BP] GO:0051336 regulation of hydrolase activity ADRA1A, CSNK2A1, DRD2, EGFR, F3, HSPA1A, HTR2A, HTR2B, MMP9, NUAK1, SMAD3, SRC, XDH 2.16882
[BP] GO:0007154 None ADORA1, ADRA1A, AR, DRD1, DRD2, DRD3, HTR2A, HTR6, HTR7, PGR, TEK 2.16545
[BP] GO:0009410 None DRD1, DRD2, DRD3, EGFR, NR3C1 2.16543
[BP] GO:1900542 None DRD1, DRD2, DRD3, HTR2A, INSR, PPARA 2.16406
[BP] GO:0042060 None ALOX15, EGFR, PPARA, SMAD3 2.16406
[BP] GO:0050714 None ACHE, DRD2, EGFR, HCAR2, HTR2B, SRC 2.15647
[BP] GO:0007611 None DRD1, DRD2, DRD3, EGFR, HTR2A, INSR 2.15647
[BP] GO:2000116 regulation of cysteine-type endopeptidase activity CSNK2A1, F3, MMP9, SMAD3, SRC, XDH 2.1475
[BP] GO:0030518 intracellular steroid hormone receptor signaling pathway AR, NR3C1, PGR, SRC 2.14667
[BP] GO:0035265 organ growth ADRA1A, AR, CYP19A1 2.14203
[BP] GO:0042743 hydrogen peroxide metabolic process CYP1A1, CYP1A2, EGFR 2.14203
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, ADRA1A, ALOX15, AR, CA9, CSNK2A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, F3, FABP3, FABP4, HSPA1A, HTR1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MET, MMP9, NR3C1, NR3C2, NUAK1, PGR, PPARA, SMAD3, SRC, TEK, XDH 2.14141
[BP] GO:0009892 negative regulation of metabolic process ADORA1, AR, CSNK2A1, CYP2D6, DRD2, DRD3, DUSP3, EGFR, FABP4, HCAR2, HSPA1A, HTR2B, IGF1R, KDR, MET, MMP9, NR3C1, PGR, PPARA, SMAD3, SRC, XDH 2.13332
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, ALOX15, ALOX5, AR, CA1, CA12, CA2, CA5A, CA5B, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, F10, F3, FABP3, FABP4, FUT7, GPR35, HCAR2, HSD17B1, HSPA1A, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PPARA, SIGMAR1, SMAD3, SRC, TEK, XDH 2.12877
[BP] GO:0044093 positive regulation of molecular function ADORA1, ADRA1A, AR, DRD2, EGFR, F3, HSPA1A, HTR2A, HTR2B, INSR, MET, MMP9, SMAD3, SRC, TEK, XDH 2.12455
[BP] GO:0006140 None DRD1, DRD2, DRD3, HTR2A, INSR, PPARA 2.10854
[BP] GO:1901890 None KDR, SMAD3, TEK 2.10854
[BP] GO:0071276 cellular response to cadmium ion CYP1A2, EGFR, MMP9 2.10854
[BP] GO:0014065 phosphatidylinositol 3-kinase signaling HTR2A, HTR2B, IGF1R 2.10854
[BP] GO:0045744 None DRD2, DRD3, MET 2.10854
[BP] GO:0048732 gland development AR, CSNK2A1, CYP19A1, EGFR, INSR, SMAD3 2.10211
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EGFR, HSPA1A, HTR1A, MMP2, MMP9, NUAK1, PPARA, SMAD3, SRC, TEK 2.09438
[BP] GO:1901652 response to peptide AKR1B1, FABP3, IGF1R, INSR, PPARA, SRC, TEK 2.09438
[BP] GO:0071407 cellular response to organic cyclic compound AR, CYP1A1, CYP1B1, DRD1, EGFR, NR3C1, SRC 2.08127
[BP] GO:1901888 regulation of cell junction assembly KDR, SMAD3, SRC, TEK 2.08127
[BP] GO:0071363 cellular response to growth factor stimulus EGFR, INSR, KDR, NR3C1, SMAD3, SRC 2.08127
[BP] GO:0098801 None ADORA1, DRD2, DRD3 2.08127
[BP] GO:0021843 None DRD1, DRD2 2.08127
[BP] GO:0021830 None DRD1, DRD2 2.08127
[BP] GO:0021826 None DRD1, DRD2 2.08127
[BP] GO:2001300 lipoxin metabolic process ALOX15, ALOX5 2.08127
[BP] GO:0016098 monoterpenoid metabolic process CYP1A2, CYP2D6 2.08127
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, HSPA1A, HTR2B, IGF1R, INSR, KDR, MET, NUAK1, SRC, TEK, XDH 2.0803
[BP] GO:0032410 None DRD2, DRD3, GPR35, MMP9 2.07195
[BP] GO:1904063 None DRD2, DRD3, GPR35, MMP9 2.07195
[BP] GO:0048729 tissue morphogenesis AR, CA2, CA9, EGFR, MET, SMAD3, SRC 2.06544
[BP] GO:0007204 positive regulation of cytosolic calcium ion concentration ADRA1A, DRD1, DRD2, GPR35, HTR2A, HTR2B 2.06405
[BP] GO:1903532 None ACHE, CYP19A1, DRD2, EGFR, HCAR2, HTR2B, SRC 2.05997
[BP] GO:0031328 positive regulation of cellular biosynthetic process AR, DRD1, DRD2, DRD3, EGFR, FABP3, HTR2A, HTR2B, IGF1R, INSR, MET, NR3C1, PGR, PPARA, SMAD3, SRC 2.0525
[BP] GO:0010907 None INSR, PPARA, SRC 2.05127
[BP] GO:0045907 None ADRA1A, EGFR, HTR2A 2.05127
[BP] GO:0060191 regulation of lipase activity ADRA1A, EGFR, HTR2A, HTR2B 2.03977
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter AR, NR3C1, NR3C2, PGR, PPARA 2.02468
[BP] GO:0001938 None F3, HTR2B, KDR, TEK 2.02284
[BP] GO:0051179 None ACHE, ADORA1, ADRA1A, ALOX15, ALOX5, AR, CA1, CA12, CA14, CA2, CA5A, CA5B, CA6, CA7, CA9, DRD1, DRD2, DRD3, EGFR, F10, FABP3, HSPA1A, HTR2A, HTR2B, MMP9, PPARA, SIGMAR1, SRC, XDH 2.02284
[BP] GO:0050789 regulation of biological process ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, ALOX15, AR, CA1, CA2, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, F10, F3, FABP3, FABP4, GPR35, HCAR2, HSPA1A, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PPARA, SIGMAR1, SMAD3, SRC, TEK, XDH 2.01967
[BP] GO:0006875 cellular metal ion homeostasis ADRA1A, DRD1, DRD2, DRD3, GPR35, HTR2A, HTR2B, SMAD3 2.01967
[BP] GO:0044089 positive regulation of cellular component biogenesis ALOX15, HSPA1A, KDR, MET, MMP1, SMAD3, SRC, TEK 2.01458
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, ADRA1A, DRD1, DRD2, DRD3, F10, F3, GPR35, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, SIGMAR1, TEK 5.80884
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, ADRA1A, ALOX15, CA2, CA9, DRD1, DRD2, DRD3, DUSP3, EGFR, F10, F3, GPR35, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, SIGMAR1, SRC, TEK 5.22108
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, ADRA1A, DRD1, DRD2, DRD3, GPR35, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, SIGMAR1, TEK 4.82607
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, ADRA1A, ALOX15, CA12, CA14, CA2, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, F10, F3, FUT7, GPR35, HCAR2, HSD11B1, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, MPEG1, NR3C2, SIGMAR1, SRC, TEK 4.15802
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ADRA1A, ALOX15, ALOX5, AR, CA12, CA14, CA2, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, EGFR, F10, F3, FUT7, GPR35, HCAR2, HSD11B1, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, MMP2, NR3C2, PGR, SIGMAR1, SMAD3, SRC, TEK 4.12751
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ADRA1A, ALOX15, AR, CA12, CA14, CA2, CA9, CSNK2A1, DRD1, DRD2, DRD3, EGFR, F10, F3, GPR35, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, MMP2, SMAD3, SRC, TEK 4.1006
[CC] GO:0098590 plasma membrane region ADORA1, ADRA1A, CA2, CA9, DRD1, DRD2, EGFR, HTR2A, INSR, MET, SIGMAR1, SRC, TEK 2.86331
[CC] GO:0005789 endoplasmic reticulum membrane CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, EGFR, HSD11B1, NR3C2, SIGMAR1 2.53608
[CC] GO:0045121 membrane raft ADRA1A, EGFR, HTR2A, INSR, KDR, SRC, TEK 2.47291
[CC] GO:0098857 membrane microdomain ADRA1A, EGFR, HTR2A, INSR, KDR, SRC, TEK 2.45819
[CC] GO:0005901 caveola ADRA1A, HTR2A, INSR, SRC 2.27058
[CC] GO:0098589 membrane region ADRA1A, EGFR, HTR2A, INSR, KDR, SRC, TEK 2.07195
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA5A, CA5B, CA6, CA7, CA9 14.542
[MF] GO:0046914 transition metal ion binding ALOX15, ALOX5, AR, CA1, CA12, CA2, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, MMP1, MMP2, MMP9, NR3C1, NR3C2, PGR, PPARA, SMAD3, XDH 12.9474
[MF] GO:0043167 ion binding ACHE, ALOX15, ALOX5, AR, CA1, CA12, CA14, CA2, CA5A, CA5B, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, EGFR, F10, F3, FABP3, FABP4, HSD17B1, HSPA1A, HTR1A, HTR2A, HTR2B, HTR5A, HTR7, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PPARA, SMAD3, SRC, TEK, XDH 11.5107
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, ADRA1A, AR, DRD1, DRD2, DRD3, EGFR, F3, GPR35, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, NR3C1, NR3C2, PGR, PPARA, SIGMAR1, TEK 10.7064
[MF] GO:0004872 receptor activity ADORA1, ADORA3, ADRA1A, AR, DRD1, DRD2, DRD3, EGFR, F3, GPR35, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, NR3C1, NR3C2, PGR, PPARA, SIGMAR1, TEK 9.54654
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, ADRA1A, AR, DRD1, DRD2, DRD3, EGFR, F3, GPR35, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, NR3C1, NR3C2, PGR, PPARA, SIGMAR1, SMAD3, TEK 9.48271
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA5A, CA5B, CA6, CA7, CA9 9.48271
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, ADRA1A, AR, DRD1, DRD2, DRD3, EGFR, F3, GPR35, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, NR3C1, NR3C2, PGR, PPARA, SIGMAR1, TEK 9.35403
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6 8.54666
[MF] GO:0070405 ammonium ion binding ACHE, DRD1, DRD2, DRD3, HTR1A, HTR2A, HTR2B, HTR5A, HTR7 8.52313
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA5A, CA5B, CA6, CA7, CA9 8.46468
[MF] GO:0008227 None ADRA1A, DRD2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 7.85626
[MF] GO:0043169 cation binding ACHE, ALOX15, ALOX5, AR, CA1, CA12, CA14, CA2, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, F10, HTR1A, HTR2A, HTR2B, HTR5A, HTR7, MMP1, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PPARA, SMAD3, XDH 7.81952
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, ADRA1A, DRD1, DRD2, DRD3, EGFR, F3, GPR35, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, SIGMAR1, TEK 7.56319
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, ADRA1A, DRD1, DRD2, DRD3, EGFR, F3, GPR35, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, SIGMAR1, TEK 7.56319
[MF] GO:0030594 None DRD1, DRD2, DRD3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 7.22175
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6 7.17841
[MF] GO:0005506 iron ion binding ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, XDH 7.12096
[MF] GO:0004993 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 7.11586
[MF] GO:0099589 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 7.11586
[MF] GO:0043176 None HTR1A, HTR2A, HTR2B, HTR5A, HTR7 7.08479
[MF] GO:0051378 None HTR1A, HTR2A, HTR2B, HTR5A, HTR7 7.08479
[MF] GO:0008144 drug binding ACHE, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6, DRD1, DRD2, DRD3, EGFR, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MET, NUAK1, PPARA, SIGMAR1, SRC, TEK 6.70818
[MF] GO:0008270 zinc ion binding AR, CA1, CA12, CA2, CA5A, CA5B, CA6, CA7, CA9, MMP1, MMP2, MMP9, NR3C1, NR3C2, PGR, PPARA, SMAD3 6.49849
[MF] GO:0099528 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 6.01792
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6 5.64105
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA5A, CA5B, CA6, CA7, CA9 5.57373
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, SRC 5.56434
[MF] GO:0042562 hormone binding ACHE, AR, EGFR, HSD17B1, IGF1R, INSR, NR3C1 5.48586
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, SRC 5.3638
[MF] GO:0042165 neurotransmitter binding ACHE, HTR1A, HTR2A, HTR2B, HTR5A, HTR7 5.3371
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6 5.20508
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity EGFR, IGF1R, INSR, KDR, MET, TEK 4.96034
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, ALOX15, ALOX5, CA1, CA12, CA14, CA2, CA5A, CA5B, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DUSP3, EGFR, F10, F3, FUT7, HSD11B1, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NUAK1, SRC, TEK, XDH 4.90963
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6, CYP2D6 4.79321
[MF] GO:0004930 None ADORA1, ADORA3, ADRA1A, DRD1, DRD2, DRD3, GPR35, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, SIGMAR1 4.6835
[MF] GO:0019199 transmembrane receptor protein kinase activity EGFR, IGF1R, INSR, KDR, MET, TEK 4.4226
[MF] GO:0016491 oxidoreductase activity AKR1B1, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, HSD11B1, HSD17B1, XDH 4.0442
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6 3.96205
[MF] GO:0003707 steroid hormone receptor activity AR, NR3C1, NR3C2, PGR, PPARA 3.72827
[MF] GO:0004713 protein tyrosine kinase activity EGFR, IGF1R, INSR, KDR, MET, SRC, TEK 3.57018
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR 3.47787
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, HSD17B1, SRC, XDH 3.37254
[MF] GO:0046872 metal ion binding ALOX15, ALOX5, AR, CA1, CA12, CA14, CA2, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, F10, MMP1, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PPARA, SMAD3, XDH 3.29504
[MF] GO:0004952 None DRD1, DRD2, DRD3 3.15038
[MF] GO:0005496 steroid binding AR, HSD17B1, NR3C1, NR3C2, PGR 3.05595
[MF] GO:0035240 None DRD1, DRD2, DRD3 3.05595
[MF] GO:0008389 None CYP2A13, CYP2A6 3.01394
[MF] GO:0008289 lipid binding ALOX15, AR, F10, F3, FABP3, FABP4, HSD17B1, NR3C1, NR3C2, PGR, PPARA 2.96726
[MF] GO:0031072 heat shock protein binding ADORA1, CSNK2A1, HSPA1A, KDR, NR3C1 2.70601
[MF] GO:1901338 None DRD1, DRD2, DRD3 2.57795
[MF] GO:0032403 protein complex binding ACHE, ADORA1, EGFR, HTR2A, IGF1R, INSR, KDR, MMP9, PPARA, SMAD3, SRC 2.45329
[MF] GO:0019838 growth factor binding EGFR, IGF1R, INSR, KDR, TEK 2.35759
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, CSNK2A1, EGFR, HTR2A, IGF1R, INSR, KDR, MMP9, PPARA, SMAD3, SRC 2.29146
[MF] GO:0043559 insulin binding IGF1R, INSR 2.21205
[MF] GO:0051879 Hsp90 protein binding CSNK2A1, KDR, NR3C1 2.08127
[MF] GO:0004064 arylesterase activity CA1, CA2 2.08127


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA5A, CA2, CA7, CA6, CA9, CA14 16.198
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 GPR35, HTR2B, HTR1A, HTR2A, NR3C1, HTR5A, ADRA1A, HTR6, HTR7, ADORA3, ADORA1, DRD1, DRD2, DRD3 10.9187
Serotonergic synapse_Homo sapiens_hsa04726 HTR6, HTR7, CYP2D6, ALOX5, ALOX15, HTR2B, HTR1A, HTR2A, HTR5A 8.4234
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B1, CYP1A1, CYP1B1, CYP19A1, IGF1R 8.1267
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP2A6, CYP2A13, CYP2D6, CYP1A2, CYP1A1, CYP1B1 7.0732
Adherens junction_Homo sapiens_hsa04520 SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R 7.0732
Calcium signaling pathway_Homo sapiens_hsa04020 HTR6, HTR7, HTR2B, HTR2A, DRD1, HTR5A, ADRA1A, EGFR 5.744
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD17B1, CYP1A2, CYP1A1, CYP1B1, CYP19A1 6.2342
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, INSR, KDR, TEK, DRD2, MET, EGFR, IGF1R 5.4087
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9, EGFR 5.528
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 5.4779
Gap junction_Homo sapiens_hsa04540 SRC, HTR2B, HTR2A, DRD1, DRD2, EGFR 5.4087
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, EGFR, IGF1R 4.4617
cAMP signaling pathway_Homo sapiens_hsa04024 HCAR2, HTR6, ADORA1, HTR1A, DRD1, DRD2, PPARA 4.4888
Ras signaling pathway_Homo sapiens_hsa04014 HTR7, INSR, KDR, TEK, MET, EGFR, IGF1R 4.1712
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KDR, MET, EGFR, IGF1R, HSPA1A 3.8511
Pathways in cancer_Homo sapiens_hsa05200 AR, SMAD3, MMP1, MMP2, MMP9, MET, EGFR, IGF1R 3.5694
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, EGFR, HSPA1A 3.8864
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 INSR, KDR, TEK, MET, EGFR, IGF1R 2.3792
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, MET, EGFR, IGF1R 2.5558
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.3192
HIF-1 signaling pathway_Homo sapiens_hsa04066 INSR, TEK, EGFR, IGF1R 2.6872
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, INSR, EGFR, IGF1R 2.3408
Metabolic pathways_Homo sapiens_hsa01100 HSD11B1, CYP2A6, FUT7, ALOX5, HSD17B1, ALOX15, CYP1A2, CYP1A1, AKR1B1, CYP19A1, XDH 2.1246
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, INSR, ADORA1 2.3792
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 INSR, IGF1R, HSPA1A 2.2437
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1 2.7357
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, INSR, ADORA1, ADRA1A 2.08
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 2.1984
Melanoma_Homo sapiens_hsa05218 MET, EGFR, IGF1R 2.1733
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1 2.2399
Prostate cancer_Homo sapiens_hsa05215 AR, EGFR, IGF1R 1.9329
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, CYP2D6, CYP1A2 2.1948
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC, HTR2B, HTR2A 1.8468
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, MMP2, F3 1.8265
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, EGFR 1.9183
Oocyte meiosis_Homo sapiens_hsa04114 AR, PGR, IGF1R 1.6123
Dopaminergic synapse_Homo sapiens_hsa04728 DRD1, DRD2, DRD3 1.5758
AMPK signaling pathway_Homo sapiens_hsa04152 INSR, ADRA1A, IGF1R 1.6123
Hepatitis B_Homo sapiens_hsa05161 SMAD3, SRC, MMP9 1.4599
MicroRNAs in cancer_Homo sapiens_hsa05206 CYP1B1, MMP9, MET, EGFR 1.3509
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 MMP9, MET, IGF1R 1.2814
MAPK signaling pathway_Homo sapiens_hsa04010 DUSP3, EGFR, HSPA1A 0.9674
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 KDR, MET, EGFR 0.9337
Glioma_Homo sapiens_hsa05214 EGFR, IGF1R 1.2913
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.3253
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PGR, IGF1R 1.0422
ErbB signaling pathway_Homo sapiens_hsa04012 SRC, EGFR 1.106
Insulin resistance_Homo sapiens_hsa04931 INSR, PPARA 0.9674
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 INSR, IGF1R 1.0676
Morphine addiction_Homo sapiens_hsa05032 ADORA1, DRD1 1.0858
Pancreatic cancer_Homo sapiens_hsa05212 SMAD3, EGFR 1.2876
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1, TEK 1.0869
Central carbon metabolism in cancer_Homo sapiens_hsa05230 MET, EGFR 1.2839
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.1774
Measles_Homo sapiens_hsa05162 CSNK2A1, HSPA1A 0.8471
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, HSPA1A 0.9329
Hepatitis C_Homo sapiens_hsa05160 PPARA, EGFR 0.8551
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.9329
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, ADORA1 0.9266
Complement and coagulation cascades_Homo sapiens_hsa04610 F10, F3 1.1753
Parkinson's disease_Homo sapiens_hsa05012 DRD1, DRD2 0.8438
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, IGF1R 0.8438
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.8438
Wnt signaling pathway_Homo sapiens_hsa04310 SMAD3, CSNK2A1 0.8438
Phospholipase D signaling pathway_Homo sapiens_hsa04072 INSR, EGFR 0.8392
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, ALOX15 1.3211
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 INSR, PPARA 0.8271
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, EGFR 0.8016
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, HSPA1A 0.6605
Alcoholism_Homo sapiens_hsa05034 DRD1, DRD2 0.7409
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC, EGFR 0.6354
Cocaine addiction_Homo sapiens_hsa05030 DRD1, DRD2 1.4781
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 INSR, NR3C2 1.6173
HTLV-I infection_Homo sapiens_hsa05166 SMAD3 0.248
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.3125
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 HSPA1A 0.3543
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3477
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3383
Tuberculosis_Homo sapiens_hsa05152 SRC 0.3474
Influenza A_Homo sapiens_hsa05164 HSPA1A 0.3477
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, XDH 1.5209
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.3381
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.3839
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 ADRA1A 0.3918
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.4192
Insulin signaling pathway_Homo sapiens_hsa04910 INSR 0.4099
Platelet activation_Homo sapiens_hsa04611 SRC 0.4417
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.4648
Cell cycle_Homo sapiens_hsa04110 SMAD3 0.4395
Axon guidance_Homo sapiens_hsa04360 MET 0.4345
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC 0.4464
Cholinergic synapse_Homo sapiens_hsa04725 ACHE 0.4648
Vascular smooth muscle contraction_Homo sapiens_hsa04270 ADRA1A 0.4441
Choline metabolism in cancer_Homo sapiens_hsa05231 EGFR 0.4883
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3 0.4812
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4883
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4995
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4995
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1 0.5036
Taste transduction_Homo sapiens_hsa04742 HTR1A 0.5267
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5161
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.5261
Salivary secretion_Homo sapiens_hsa04970 ADRA1A 0.5161
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5161
Peroxisome_Homo sapiens_hsa04146 XDH 0.5267
Chronic myeloid leukemia_Homo sapiens_hsa05220 SMAD3 0.5592
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC 0.5604
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5581
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5627
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.5471
Bile secretion_Homo sapiens_hsa04976 CA2 0.5615
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5768
Amphetamine addiction_Homo sapiens_hsa05031 DRD1 0.5753
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.5782
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.5914
Colorectal cancer_Homo sapiens_hsa05210 SMAD3 0.5832
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3 0.5782
Shigellosis_Homo sapiens_hsa05131 SRC 0.5782
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B1 0.5935
Non-small cell lung cancer_Homo sapiens_hsa05223 EGFR 0.6092
Endometrial cancer_Homo sapiens_hsa05213 EGFR 0.6291
Legionellosis_Homo sapiens_hsa05134 HSPA1A 0.6117
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2 1.8468
Malaria_Homo sapiens_hsa05144 MET 0.643
Type II diabetes mellitus_Homo sapiens_hsa04930 INSR 0.6465
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.7542
Galactose metabolism_Homo sapiens_hsa00052 AKR1B1 0.8016
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.8286
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7934
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B1 0.7479
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B1 0.7857
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2 0.8471
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8327
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8286
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 5.415


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)