TCM Prescription: Ba Zheng Recipe



Prescription Description
Prescription IDTCMF229
Pinyin NameBa Zheng He Ji 
Chinese Name八正合剂
English NameBa Zheng Recipe
Function Description热淋
IndicationsHeat stranguria disorder, Acute prostatitis, Chronic prostatitis, Salmonella pyelonephritis, Chronic pyelonephritis, Cystitis, Urethritis
Disease ICD-11 Category SA91 [Heat stranguria disorder (TM1), 热淋 (TM1) ];
GA91.Y [Other specified inflammatory and other diseases of prostate, 其他特指的前列腺炎性疾病 ];
GA91.0 [Chronic prostatitis, 慢性前列腺炎 ];
GC2Z [Diseases of the urinary system, unspecified, 泌尿系统疾病，未特指的 ];
GB55.Z [Chronic tubulo-interstitial nephritis, unspecified, 慢性肾小管-间质肾炎，未特指的 ];
GC00 [Cystitis, 膀胱炎 ];
GC02.Y [Other specified urethritis and urethral syndrome, 其他特指的尿道炎和尿道综合征 ];
Human Tissues Associated with IndicationBladder
ReferenceChinese pharmacopoeia (2015)
Reference Book/linkISBN 978-7-5067-7337-9
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1706 Dianthus superbus 瞿麦 TCMH1706 ITSAJ4556-14
TCMH241 Plantago asiatica 车前子 TCMH241 ITSAB3641-14
TCMH177 Polygonum aviculare 萹蓄 TCMH177 ITSAG3700-14
TCMH363 Rheum officinale 大黄 TCMH363 ITSAJ4685-14
TCMH933 Talcum 滑石 TCMH933
TCMH287 Clematidis armandii caulis 川木通 TCMH287
TCMH2641 Gardenia jasminoides 栀子 TCMH2641 ITSAJ4473-14
TCMH628 Glycyrrhiza uralensis 甘草 TCMH628 ITSAM892-14
TCMH438 Juncus effusus 灯心草 TCMH438 ITSAD4376-14
Reference: Chinese pharmacopoeia (2015)

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT114 CNR2 Cannabinoid CB2 receptor GPCR P34972
TCMT115 CNR1 Cannabinoid CB1 receptor GPCR P21554
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT151 PRKCA Protein kinase C alpha Kinase P17252
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT160 HTR7 Serotonin 7 (5-HT7) receptor GPCR P34969
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT207 BACE1 Beta-secretase 1 Protease P56817
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT214 MGLL Monoglyceride lipase Unclassified Q99685
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT22 ALPI Intestinal alkaline phosphatase Hydrolase P09923
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT231 GBA2 Beta-glucosidase Hydrolase Q9HCG7
TCMT232 ABCB1 P-glycoprotein 1 Transporter P08183
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT304 MMP14 Matrix metalloproteinase 14 Hydrolase P50281
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT307 KCNH2 HERG Ion channel Q12809
TCMT313 HTR2B Serotonin 2b (5-HT2b) receptor GPCR P41595
TCMT314 HTR2C Serotonin 2c (5-HT2c) receptor GPCR P28335
TCMT315 HTR6 Serotonin 6 (5-HT6) receptor GPCR P50406
TCMT318 HKDC1 Putative hexokinase HKDC1 Transferase Q2TB90
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT334 EBP 3-beta-hydroxysteroid-delta(8),delta(7)-isomerase Isomerase Q15125
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT36 HTR1A Serotonin 1a (5-HT1a) receptor GPCR P08908
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT37 HTR2A Serotonin 2a (5-HT2a) receptor GPCR P28223
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT434 JAK2 Tyrosine-protein kinase JAK2 Kinase O60674
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT508 SYK Tyrosine-protein kinase SYK Kinase P43405
TCMT510 KIT Stem cell growth factor receptor Kinase P10721
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT567 DNMT1 DNA (cytosine-5)-methyltransferase 1 Transferase P26358
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT645 HTR1E Serotonin 1e (5-HT1e) receptor GPCR P28566
TCMT646 HTR5A Serotonin 5a (5-HT5a) receptor GPCR P47898
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT729 PIK3CA PI3-kinase p110-alpha subunit Transferase P42336
TCMT730 PIK3CB PI3-kinase p110-beta subunit Transferase P42338
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT751 DYRK1A Dual-specificity tyrosine-phosphorylation regulated kinase 1A Kinase Q13627
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT815 HTR1D Serotonin 1d (5-HT1d) receptor GPCR P28221
TCMT816 HTR1B Serotonin 1b (5-HT1b) receptor GPCR P28222
TCMT817 HTR4 Serotonin 4 (5-HT4) receptor GPCR Q13639
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT881 BBOX1 Gamma-butyrobetaine dioxygenase Oxidoreductase O75936
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1183 Candida albicans SC5314
TCMT1186 Plasmodium yoelii yoelii
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1198 Serratia marcescens
TCMT1201 Staphylococcus epidermidis ATCC 12228
TCMT1207 Legionella pneumophila
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1243 Aspergillus flavus
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1294 Human parainfluenza virus 3
TCMT1296 Influenza A virus H3N2
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0007210 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 16.0056
[BP] GO:0098664 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 16.0056
[BP] GO:0042221 response to chemical ABCB1, AKR1B1, ALOX15, ALPL, APEX1, APP, AXL, BCL2, CA2, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, ESR1, ESRRA, FABP4, FLT3, HSD11B2, HSD17B2, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR5A, IGF1R, JAK2, KCNH2, KDR, KIT, MMP2, MMP9, PIK3CA, PRKCA, PTGS2, RORC, SRC, TERT, TYR 13.3493
[BP] GO:0065008 regulation of biological quality ABCB1, ACHE, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CA12, CA2, CA7, CDK6, CNR1, CNR2, CYP19A1, CYP1A1, CYP1B1, ESR1, F3, FABP4, FLT3, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR4, HTR7, JAK2, KCNH2, KDR, KIT, MET, PIK3CA, PIK3CB, PRKCA, PTGS1, PTGS2, SRC, TERT, TNKS, TNKS2, XDH 12.3497
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APEX1, APP, AXL, BCL2, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, ESR1, ESRRA, HSD11B2, HSD17B2, HTR1B, HTR5A, IGF1R, JAK2, MMP2, MMP9, PIK3CA, PTGS2, RORC, SRC, TYR 10.6124
[BP] GO:0010033 response to organic substance AKR1B1, ALOX15, ALPL, APEX1, APP, AXL, BCL2, CA2, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, ESR1, ESRRA, FABP4, FLT3, HSD11B2, HSD17B2, HTR1B, HTR5A, IGF1R, JAK2, KDR, KIT, MMP2, PIK3CA, PRKCA, PTGS2, RORC, SRC, TYR 10.2187
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FLT3, HSD11B2, HSD17B2, HTR1B, HTR5A, JAK2, PTGS2, RORC, SRC, TYR 10.0689
[BP] GO:0006629 lipid metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPI, APP, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EBP, ESR1, FABP4, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, KIT, MET, MGLL, PIK3CA, PIK3CB, PTGS1, PTGS2 9.64266
[BP] GO:0010647 positive regulation of cell communication AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F3, FLT3, HTR2A, HTR2B, HTR2C, HTR6, JAK2, KDR, KIT, MET, MMP12, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 9.51918
[BP] GO:0023056 positive regulation of signaling AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F3, FLT3, HTR2A, HTR2B, HTR2C, HTR6, JAK2, KDR, KIT, MET, MMP12, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 9.48911
[BP] GO:0048522 positive regulation of cellular process ACHE, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, JAK2, KCNH2, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PRKCA, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 8.97674
[BP] GO:0042127 regulation of cell proliferation ADORA3, AKR1B1, APP, BCL2, CDC25B, CDK6, CSNK2A1, CYP1B1, DNMT1, ESR1, ESRRA, F3, FLT3, HTR1A, HTR1B, HTR2A, HTR2B, IGF1R, JAK2, KDR, KIT, MMP12, MMP2, MMP9, PIM1, PRKCA, PTGS1, PTGS2, SRC, TERT, XDH 8.88079
[BP] GO:0010646 regulation of cell communication ACHE, AKR1B1, ALOX15, APP, AURKB, AXL, BACE1, BCL2, CA2, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DYRK1A, ESR1, ESR2, F3, FLT3, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, JAK2, KDR, KIT, MET, MGLL, MMP12, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 8.81642
[BP] GO:0023051 regulation of signaling ACHE, AKR1B1, ALOX15, APP, AURKB, AXL, BACE1, BCL2, CA2, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DYRK1A, ESR1, ESR2, F3, FLT3, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, JAK2, KDR, KIT, MET, MGLL, MMP12, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 8.66346
[BP] GO:0008152 metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPI, ALPL, AOX1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, EBP, ESR1, ESR2, ESRRA, ESRRB, F3, FABP4, FLT3, FUT7, GBA2, GLO1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR1A, HTR1B, HTR2B, HTR2C, IGF1R, JAK2, KCNH2, KDR, KIT, MET, MGLL, MMP1, MMP12, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PRKCA, PTGS1, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 8.60712
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CDC25B, CDK6, CSNK2A1, ESR1, F3, FLT3, HTR1A, HTR1B, HTR2A, HTR2B, IGF1R, JAK2, KDR, KIT, MMP12, MMP2, MMP9, PIM1, PRKCA, PTGS2, TERT 8.46217
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EBP, ESR1, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2 8.46217
[BP] GO:0050896 response to stimulus ABCB1, ACHE, ADORA3, AKR1B1, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA2, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, ESR1, ESRRA, F3, FABP4, FLT3, HSD11B2, HSD17B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR5A, IGF1R, JAK2, KCNH2, KDR, KIT, MGLL, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS1, PTGS2, PTPN1, RORC, SRC, TERT, TOP2A, TYR 8.46217
[BP] GO:0014070 response to organic cyclic compound ALPL, APEX1, APP, BCL2, CA2, CA9, CNR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FLT3, HSD11B2, HTR1B, HTR5A, PTGS2, RORC, SRC, TYR 8.36586
[BP] GO:0009967 positive regulation of signal transduction AKR1B1, ALOX15, APP, AXL, BCL2, CSNK2A1, CYP1B1, F3, FLT3, HTR2A, HTR2B, HTR2C, HTR6, JAK2, KDR, KIT, MET, MMP12, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 8.30554
[BP] GO:0043067 regulation of programmed cell death AKR1B1, APEX1, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, ESR1, F3, FLT3, GLO1, HTR2B, IGF1R, JAK2, KDR, KIT, MET, MMP9, PIK3CA, PIK3CB, PIM1, PRKCA, PTGS2, PTPN1, SRC, TERT, TOP2A, XDH 8.27544
[BP] GO:0048518 positive regulation of biological process ABCB1, ACHE, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FABP4, FLT3, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, JAK2, KCNH2, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PRKCA, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 8.1147
[BP] GO:0032501 multicellular organismal process AKR1B1, AKR1B10, ALOX15, ALOX5, ALPI, ALPL, APP, AXL, BCL2, CNR1, CNR2, CYP19A1, CYP1A2, CYP1B1, ESR1, ESRRB, F3, FABP4, HSD11B2, HSD17B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR7, IGF1R, JAK2, KCNH2, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIM1, PTGS2, RORC, SRC, TNKS2, TYR 7.96826
[BP] GO:0032502 developmental process ACHE, AKR1B1, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA2, CA9, CDC25B, CDK6, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DYRK1A, EBP, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, GBA2, GLO1, HSD11B1, HSD17B2, HTR2A, HTR2B, HTR5A, JAK2, KDR, KIT, MET, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PRKCA, PTGS2, RORC, SRC, TERT, TNKS2, TOP2A, TYR 7.96826
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, APEX1, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, KIT, MMP9, PTGS2, SRC, TERT 7.93729
[BP] GO:1902533 positive regulation of intracellular signal transduction AKR1B1, ALOX15, APP, AXL, BCL2, CYP1B1, F3, FLT3, HTR2A, HTR2B, HTR2C, HTR6, JAK2, KDR, KIT, MET, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SRC, XDH 7.73342
[BP] GO:0010941 regulation of cell death AKR1B1, APEX1, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, ESR1, F3, FLT3, GLO1, HTR2B, IGF1R, JAK2, KDR, KIT, MET, MMP9, PIK3CA, PIK3CB, PIM1, PRKCA, PTGS2, PTPN1, SRC, TERT, TOP2A, XDH 7.55736
[BP] GO:0042493 response to drug ABCB1, AKR1B1, APEX1, AXL, BCL2, CA9, CDK6, CNR1, CNR2, CYP1A1, CYP1B1, HSD11B2, HTR1B, HTR2A, HTR2B, HTR2C, KCNH2, KDR, PTGS2, SRC 7.4737
[BP] GO:0048584 positive regulation of response to stimulus AKR1B1, ALOX15, APP, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, ESRRA, F3, FABP4, FLT3, HTR2A, HTR2B, HTR2C, HTR6, JAK2, KDR, KIT, MET, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 7.3637
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, ALPI, ALPL, APEX1, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DYRK1A, FLT3, HTR2B, HTR2C, IGF1R, JAK2, KCNH2, KDR, KIT, MET, PIK3CA, PIK3CB, PIM1, PRKCA, PTGS2, PTPN1, SRC, TNKS, XDH 7.14353
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EBP, FUT7, GBA2, GLO1, HTR2B, HTR2C, MGLL, PIK3CA, PIM1, PTGS1, PTGS2, TYR, XDH 7.14256
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALOX15, ALPL, APEX1, APP, AXL, BCL2, CDK6, CYP1A1, CYP1A2, CYP1B1, DNMT1, ESR1, FABP4, FLT3, HTR1B, IGF1R, KCNH2, KDR, KIT, MMP2, MMP9, PIK3CA, PTGS2, RORC, SRC, TERT 7.12355
[BP] GO:0042981 regulation of apoptotic process AKR1B1, APEX1, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, ESR1, F3, FLT3, GLO1, HTR2B, IGF1R, JAK2, KDR, MMP9, PIK3CA, PIK3CB, PIM1, PRKCA, PTGS2, PTPN1, SRC, TERT, TOP2A, XDH 7.01038
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPI, ALPL, AOX1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, FABP4, FLT3, FUT7, GBA2, GLO1, HSD17B1, HSD17B2, HTR1A, HTR1B, HTR2B, HTR2C, IGF1R, JAK2, KCNH2, KDR, KIT, MET, MGLL, MMP1, MMP2, NQO2, PIK3CA, PIK3CB, PIM1, PRKCA, PTGS1, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 6.85409
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX15, ALPI, CSNK2A1, CYP19A1, CYP1A1, EBP, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MGLL, PIK3CA, PIK3CB, PTGS1, PTGS2 6.85409
[BP] GO:0007198 None HTR1A, HTR1B, HTR5A, HTR7 6.83373
[BP] GO:0097756 None HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 6.82081
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, ALPI, ALPL, APEX1, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DYRK1A, FLT3, HTR2B, HTR2C, IGF1R, JAK2, KCNH2, KDR, KIT, MET, PIK3CA, PIK3CB, PIM1, PRKCA, PTGS2, PTPN1, SRC, TNKS, XDH 6.73451
[BP] GO:1902531 regulation of intracellular signal transduction AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DYRK1A, ESR1, F3, FLT3, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, JAK2, KDR, KIT, MET, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SRC, XDH 6.63172
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DYRK1A, FLT3, HTR2B, IGF1R, JAK2, KCNH2, KDR, KIT, MET, PIK3CA, PIM1, PRKCA, SRC, TNKS 6.57615
[BP] GO:0032879 regulation of localization ABCB1, ACHE, ADORA3, ALOX15, APEX1, APP, AXL, BCL2, CA2, CA7, CDK6, CNR1, CSNK2A1, CYP19A1, CYP1B1, F3, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, IGF1R, JAK2, KCNH2, KDR, KIT, MET, MMP12, MMP9, PIK3CB, PRKCA, PTGS2, PTPN1, SRC, TERT 6.57615
[BP] GO:0010817 regulation of hormone levels ACHE, AKR1B1, CNR1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR1A, HTR2A, HTR2C, JAK2, PRKCA 6.5186
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.48836
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA3, AKR1B1, APEX1, APP, AURKB, AXL, BCL2, CDK6, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, FABP4, GLO1, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, JAK2, KCNH2, KDR, KIT, MET, MMP12, MMP9, PIK3CA, PIM1, PRKCA, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 6.47519
[BP] GO:0048583 regulation of response to stimulus ABCB1, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CDK6, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DYRK1A, ESR1, ESR2, ESRRA, F3, FABP4, FLT3, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, JAK2, KDR, KIT, MET, MGLL, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 6.47519
[BP] GO:0043069 negative regulation of programmed cell death AKR1B1, AURKB, AXL, BCL2, CSNK2A1, GLO1, HTR2B, IGF1R, JAK2, KDR, KIT, MET, MMP9, PIK3CA, PIM1, PRKCA, PTGS2, PTPN1, SRC, TERT 6.38039
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APEX1, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A2, DNMT1, ESR1, ESRRA, FLT3, HSD11B2, HTR1B, HTR5A, IGF1R, KIT, MMP2, PTGS2, SRC 6.25407
[BP] GO:0007165 signal transduction ADORA3, AKR1B1, APP, AXL, BCL2, CA1, CA2, CDK6, CNR1, CNR2, CSNK2A1, CYP1B1, DNMT1, EBP, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, JAK2, KCNH2, KDR, KIT, MET, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PRKCA, PTPN1, RORC, SRC, TNKS, TNKS2 6.18922
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALOX15, ALPL, APEX1, APP, AXL, BCL2, CDK6, CYP1A1, CYP1B1, DNMT1, ESR1, FABP4, FLT3, HTR1B, IGF1R, KDR, KIT, MMP2, PIK3CA, PTGS2, RORC, SRC 6.09789
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, TYR 6.07473
[BP] GO:0032844 regulation of homeostatic process AURKB, BCL2, CA2, CA7, CDK6, CNR1, HTR2A, HTR2B, HTR2C, KDR, PIK3CB, PTGS2, SRC, TNKS, TNKS2 6.06235
[BP] GO:0042310 None HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7 6.06235
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, APEX1, AXL, BCL2, CNR1, CNR2, CYP1A1, CYP1B1, HTR1B, HTR1D, JAK2, KDR, SRC 6.06164
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ALOX15, APP, AURKB, BCL2, CDC25B, CSNK2A1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, JAK2, KDR, KIT, MET, MMP12, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 6.02582
[BP] GO:0019369 arachidonic acid metabolic process ALOX15, CYP1A1, CYP1A2, CYP1B1, MGLL, PTGS1, PTGS2 5.92288
[BP] GO:0009725 response to hormone AKR1B1, ALPL, APEX1, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FLT3, HSD11B2, HTR1B, HTR5A, KIT, PTGS2, SRC 5.86699
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DYRK1A, FLT3, HTR2B, IGF1R, JAK2, KCNH2, KDR, KIT, MET, PIK3CA, PIK3CB, PIM1, PRKCA, SRC, TNKS 5.84093
[BP] GO:0060548 negative regulation of cell death AKR1B1, AURKB, AXL, BCL2, CSNK2A1, GLO1, HTR2B, IGF1R, JAK2, KDR, KIT, MET, MMP9, PIK3CA, PIM1, PRKCA, PTGS2, PTPN1, SRC, TERT 5.79072
[BP] GO:0071704 organic substance metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPI, ALPL, AOX1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, EBP, ESR1, ESR2, ESRRA, ESRRB, F3, FABP4, FLT3, FUT7, GBA2, GLO1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR1A, HTR1B, HTR2B, HTR2C, IGF1R, JAK2, KCNH2, KDR, KIT, MET, MGLL, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PRKCA, PTGS1, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 5.62333
[BP] GO:0007187 None CNR1, CNR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR4, HTR5A, HTR6, HTR7 5.61003
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA3, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CDK6, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, FABP4, GLO1, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, JAK2, KCNH2, KDR, KIT, MET, MMP12, MMP9, PIK3CA, PIM1, PRKCA, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 5.59737
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 5.57477
[BP] GO:0010604 positive regulation of macromolecule metabolic process ALOX15, APP, AURKB, BCL2, CDC25B, CSNK2A1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, JAK2, KDR, KIT, MET, MMP12, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 5.57335
[BP] GO:0042327 positive regulation of phosphorylation ALOX15, APP, BCL2, CDC25B, ESRRB, FLT3, HTR2A, HTR2B, HTR2C, JAK2, KDR, KIT, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SRC, XDH 5.53491
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 5.53301
[BP] GO:0040012 regulation of locomotion ADORA3, APEX1, APP, BCL2, CDK6, CYP19A1, CYP1B1, F3, HTR1D, IGF1R, JAK2, KDR, KIT, MET, MMP9, PRKCA, PTGS2, SRC, TERT 5.52595
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, MGLL, PTGS1, PTGS2 5.52595
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA2, CA9, CDK6, CYP1A1, CYP1A2, CYP1B1, DNMT1, ESR1, FABP4, FLT3, HTR1B, IGF1R, JAK2, KCNH2, KDR, KIT, MMP2, MMP9, PIK3CA, PTGS2, PTPN1, RORC, SRC, TERT, TOP2A 5.51673
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, NQO2, PTGS1, PTGS2, TYR, XDH 5.49816
[BP] GO:0044238 primary metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPI, ALPL, AOX1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, EBP, ESR1, ESR2, ESRRA, ESRRB, F3, FABP4, FLT3, FUT7, GBA2, GLO1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR2B, HTR2C, IGF1R, JAK2, KCNH2, KDR, KIT, MET, MGLL, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PRKCA, PTGS1, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 5.46028
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, DYRK1A, FLT3, IGF1R, JAK2, KDR, KIT, PIM1, SRC 5.37968
[BP] GO:0006690 icosanoid metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, MGLL, PTGS1, PTGS2 5.31832
[BP] GO:2000145 regulation of cell motility ADORA3, APEX1, APP, BCL2, CDK6, CYP19A1, CYP1B1, F3, IGF1R, JAK2, KDR, KIT, MET, MMP9, PRKCA, PTGS2, SRC, TERT 5.31832
[BP] GO:0001934 positive regulation of protein phosphorylation ALOX15, APP, BCL2, CDC25B, FLT3, HTR2A, HTR2B, HTR2C, JAK2, KDR, KIT, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SRC, XDH 5.15831
[BP] GO:0031325 positive regulation of cellular metabolic process ALOX15, APP, AURKB, BCL2, CDC25B, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, JAK2, KDR, KIT, MET, MMP12, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 5.13243
[BP] GO:1903727 positive regulation of phospholipid metabolic process FLT3, HTR2A, HTR2B, HTR2C, KIT, SRC 5.11875
[BP] GO:0043066 negative regulation of apoptotic process AKR1B1, AURKB, AXL, BCL2, CSNK2A1, GLO1, HTR2B, IGF1R, JAK2, KDR, MMP9, PIK3CA, PIM1, PRKCA, PTGS2, PTPN1, SRC, TERT 5.09556
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation HTR1B, JAK2, MMP2, MMP9, TERT 5.08768
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX15, ALOX5, ALPI, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP4, FUT7, GBA2, KIT, MET, MGLL, PIK3CA, PIK3CB, PTGS1, PTGS2 5.04921
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, JAK2, KDR, KIT, MET, MMP2, MMP9, PIK3CA, PIK3CB, PRKCA, PTPN1, SRC 5.03212
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, HTR1B, JAK2, MMP2, MMP9, PTGS2, TERT 5.01289
[BP] GO:0009966 regulation of signal transduction AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DYRK1A, ESR1, ESR2, F3, FLT3, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, JAK2, KDR, KIT, MET, MGLL, MMP12, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 5.01078
[BP] GO:0030334 regulation of cell migration ADORA3, APEX1, APP, BCL2, CYP19A1, CYP1B1, F3, IGF1R, JAK2, KDR, KIT, MET, MMP9, PRKCA, PTGS2, SRC, TERT 4.9985
[BP] GO:0043410 positive regulation of MAPK cascade ALOX15, APP, FLT3, HTR2A, HTR2B, HTR2C, JAK2, KDR, KIT, PIK3CB, PRKCA, PTPN1, SRC, XDH 4.92359
[BP] GO:0031401 positive regulation of protein modification process ALOX15, APP, BCL2, CDC25B, DNMT1, DYRK1A, FLT3, HTR2A, HTR2B, HTR2C, JAK2, KDR, KIT, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SRC, XDH 4.91101
[BP] GO:0010562 positive regulation of phosphorus metabolic process ALOX15, APP, BCL2, CDC25B, ESRRB, FLT3, HTR2A, HTR2B, HTR2C, JAK2, KDR, KIT, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SRC, XDH 4.88379
[BP] GO:0045937 positive regulation of phosphate metabolic process ALOX15, APP, BCL2, CDC25B, ESRRB, FLT3, HTR2A, HTR2B, HTR2C, JAK2, KDR, KIT, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SRC, XDH 4.88379
[BP] GO:0009893 positive regulation of metabolic process ALOX15, APP, AURKB, BCL2, CDC25B, CSNK2A1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, JAK2, KDR, KIT, MET, MMP12, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 4.87158
[BP] GO:0051270 regulation of cellular component movement ADORA3, APEX1, APP, BCL2, CDK6, CYP19A1, CYP1B1, F3, IGF1R, JAK2, KDR, KIT, MET, MMP9, PRKCA, PTGS2, SRC, TERT 4.85659
[BP] GO:0030335 positive regulation of cell migration APP, BCL2, F3, IGF1R, JAK2, KDR, KIT, MET, MMP9, PRKCA, PTGS2, SRC, TERT 4.81252
[BP] GO:0042592 homeostatic process AKR1B1, APEX1, APP, AXL, BCL2, CA12, CA2, CA7, CNR1, ESR1, FABP4, FLT3, HTR2A, HTR2B, HTR2C, JAK2, KCNH2, MET, PIK3CA, PIK3CB, SRC, TERT 4.7318
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, APP, BACE1, CA2, CA7, CNR1, CNR2, HTR1B, HTR2A, KIT, PTGS2 4.7318
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, APP, BACE1, CA2, CA7, CNR1, CNR2, HTR1B, HTR2A, KIT, PTGS2 4.7318
[BP] GO:0051247 positive regulation of protein metabolic process ALOX15, APP, BCL2, CDC25B, CSNK2A1, DNMT1, DYRK1A, ESR1, F3, FLT3, HTR2A, HTR2B, HTR2C, JAK2, KDR, KIT, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SRC, XDH 4.68376
[BP] GO:2000147 positive regulation of cell motility APP, BCL2, F3, IGF1R, JAK2, KDR, KIT, MET, MMP9, PRKCA, PTGS2, SRC, TERT 4.66478
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, DYRK1A, FLT3, IGF1R, JAK2, KDR, KIT, MET, SRC 4.59152
[BP] GO:0018212 peptidyl-tyrosine modification AXL, DYRK1A, FLT3, IGF1R, JAK2, KDR, KIT, MET, SRC 4.54122
[BP] GO:0051272 positive regulation of cellular component movement APP, BCL2, F3, IGF1R, JAK2, KDR, KIT, MET, MMP9, PRKCA, PTGS2, SRC, TERT 4.54122
[BP] GO:0032270 positive regulation of cellular protein metabolic process ALOX15, APP, BCL2, CDC25B, DNMT1, DYRK1A, ESR1, F3, FLT3, HTR2A, HTR2B, HTR2C, JAK2, KDR, KIT, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SRC, XDH 4.52394
[BP] GO:0010038 response to metal ion ALOX15, APP, BCL2, CA2, CYP1A1, CYP1A2, FABP4, KIT, MMP9, PTGS2, TERT 4.52394
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA3, APP, CA2, CNR1, CNR2, ESR1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, JAK2, PIK3CA, PIK3CB, SRC 4.52034
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EBP, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, KDR, KIT, PIK3CA, SRC, TYR 4.44193
[BP] GO:0014065 phosphatidylinositol 3-kinase signaling HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB 4.41874
[BP] GO:0040017 positive regulation of locomotion APP, BCL2, F3, IGF1R, JAK2, KDR, KIT, MET, MMP9, PRKCA, PTGS2, SRC, TERT 4.39575
[BP] GO:0032228 regulation of synaptic transmission, GABAergic CA2, CA7, CNR1, CNR2, HTR1B 4.3524
[BP] GO:0065007 biological regulation ABCB1, ACHE, ADORA3, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA7, CA9, CDC25B, CDK6, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, EBP, ESR1, ESR2, ESRRA, ESRRB, F3, FABP4, FLT3, GLO1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, JAK2, KCNH2, KDR, KIT, MET, MGLL, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PRKCA, PTGS1, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 4.33416
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.33416
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALOX15, APP, BCL2, CYP19A1, CYP1A1, CYP1B1, EBP, GBA2, HTR1A, TYR 4.31801
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX15, CYP1A1, CYP1A2, CYP1B1, MGLL, PTGS1, PTGS2 4.31801
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.30295
[BP] GO:0080134 regulation of response to stress ABCB1, APP, CDK6, CNR1, CNR2, CYP19A1, DYRK1A, ESR1, F3, FABP4, IGF1R, JAK2, MET, MGLL, MMP12, MMP2, PRKCA, PTGS2, PTPN1, SRC, TERT, XDH 4.28308
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPI, ALPL, AOX1, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, DYRK1A, ESR1, F3, FLT3, FUT7, GBA2, GLO1, HTR1A, HTR2B, HTR2C, IGF1R, JAK2, KCNH2, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIM1, PRKCA, PTGS2, PTPN1, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 4.26447
[BP] GO:0051049 regulation of transport ABCB1, ACHE, ALOX15, APP, AXL, BCL2, CA2, CA7, CNR1, CYP19A1, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, JAK2, KCNH2, MMP12, MMP9, PIK3CB, PRKCA, PTGS2, PTPN1, SRC, TERT 4.26447
[BP] GO:0006979 response to oxidative stress AKR1B1, APEX1, APP, AXL, BCL2, CYP1B1, JAK2, MMP9, PTGS1, PTGS2, SRC 4.2625
[BP] GO:0050795 None CNR1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B 4.23373
[BP] GO:0019220 regulation of phosphate metabolic process ALOX15, APP, BCL2, CDC25B, ESRRB, FABP4, FLT3, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, JAK2, KDR, KIT, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SRC, XDH 4.21188
[BP] GO:1901568 fatty acid derivative metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, MGLL, PTGS1, PTGS2 4.18397
[BP] GO:0003018 None HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2, SRC 4.18397
[BP] GO:0051174 regulation of phosphorus metabolic process ALOX15, APP, BCL2, CDC25B, ESRRB, FABP4, FLT3, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, JAK2, KDR, KIT, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SRC, XDH 4.15918
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CDK6, CYP1B1, HTR1B, KCNH2, KDR, PTGS2, SRC 4.13481
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.13047
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, DYRK1A, ESR1, HTR7, KIT, RORC, SRC, TOP2A 4.11551
[BP] GO:0042325 regulation of phosphorylation ALOX15, APP, BCL2, CDC25B, ESRRB, FABP4, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, JAK2, KDR, KIT, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SRC, XDH 4.11525
[BP] GO:0001932 regulation of protein phosphorylation ALOX15, APP, BCL2, CDC25B, FABP4, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, JAK2, KDR, KIT, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SRC, XDH 4.11525
[BP] GO:0048856 anatomical structure development ACHE, AKR1B1, ALOX15, ALPL, APP, AXL, BCL2, CA2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DYRK1A, EBP, ESR1, ESRRA, ESRRB, FLT3, GBA2, HSD11B1, HSD17B2, HTR5A, JAK2, KDR, KIT, MMP9, PIK3CA, PIM1, PTGS2, RORC, SRC, TYR 4.10645
[BP] GO:0043408 regulation of MAPK cascade ALOX15, APP, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, JAK2, KDR, KIT, PIK3CB, PRKCA, PTPN1, SRC, XDH 4.06546
[BP] GO:1904705 regulation of vascular smooth muscle cell proliferation HTR1B, JAK2, MMP2, MMP9, TERT 3.98218
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CNR1, CNR2, CSNK2A1, CYP1B1, ESR1, FABP4, IGF1R, JAK2, MET, MMP9, PIM1, PRKCA, PTGS2, PTPN1, SRC, TNKS 3.97807
[BP] GO:1903725 regulation of phospholipid metabolic process FLT3, HTR2A, HTR2B, HTR2C, KIT, SRC 3.97637
[BP] GO:0010513 None HTR2A, HTR2B, HTR2C 3.97198
[BP] GO:0048878 chemical homeostasis AKR1B1, APP, BCL2, CA12, CA2, CA7, CNR1, ESR1, FABP4, HTR2A, HTR2B, HTR2C, JAK2, KCNH2, MET, PIK3CA, PIK3CB 3.95553
[BP] GO:0009987 cellular process ABCB1, ACHE, ADORA3, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPI, ALPL, AOX1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CDK6, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, EBP, ESR1, ESR2, ESRRA, ESRRB, F3, FABP4, FLT3, FUT7, GBA2, GLO1, HSD17B1, HSD17B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, JAK2, KCNH2, KDR, KIT, MET, MGLL, MMP1, MMP12, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PRKCA, PTGS1, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 3.92437
[BP] GO:0007193 None HTR1A, HTR1B, HTR1D, HTR1E, HTR5A, HTR7 3.84637
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, JAK2, PIM1, RORC, SRC 3.83497
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APEX1, APP, AXL, CDK6, CYP1B1, DNMT1, ESR1, IGF1R, MMP2, MMP9, PIK3CA, PTGS2, RORC, SRC 3.82455
[BP] GO:0008283 cell proliferation ABCB1, ACHE, AURKB, BCL2, CYP1A1, ESR1, FLT3, HTR1A, KIT, MET, PIK3CB, PIM1, SRC, TYR 3.82455
[BP] GO:0045834 positive regulation of lipid metabolic process FLT3, HTR2A, HTR2B, HTR2C, KIT, PTGS2, SRC 3.79482
[BP] GO:0097746 None HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 3.7758
[BP] GO:0035296 None HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 3.7758
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, EBP, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.73369
[BP] GO:0050790 regulation of catalytic activity ADORA3, APP, AURKB, BCL2, CDC25B, CNR1, CNR2, CSNK2A1, ESR1, F3, FABP4, FLT3, HTR2A, HTR2B, IGF1R, JAK2, KIT, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SRC, TERT, TNKS, XDH 3.70955
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, HTR1B, JAK2, MMP2, MMP9, PTGS2, TERT 3.69234
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, FLT3, IGF1R, JAK2, KDR, KIT, MET, MMP2, MMP9, PIK3CA, PIK3CB, PRKCA, PTPN1, SRC 3.68957
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, JAK2, RORC, SRC 3.65173
[BP] GO:0051239 regulation of multicellular organismal process ADORA3, APP, AXL, BCL2, CA2, CDK6, CNR1, CYP1B1, ESR1, ESRRA, ESRRB, F3, HTR2A, HTR2B, HTR2C, JAK2, KCNH2, KDR, KIT, MET, MGLL, MMP12, MMP9, PIK3CA, PIM1, PRKCA, PTGS2, SRC, TERT, TNKS2, XDH 3.63979
[BP] GO:0050880 None HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 3.61181
[BP] GO:0035150 None HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 3.59212
[BP] GO:0031399 regulation of protein modification process ALOX15, APP, BCL2, CDC25B, DNMT1, DYRK1A, FABP4, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, JAK2, KDR, KIT, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SRC, XDH 3.57452
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA3, ALOX15, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FABP4, FLT3, GLO1, HTR1A, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, JAK2, KDR, KIT, MET, MMP12, MMP9, PIK3CA, PIK3CB, PIM1, PRKCA, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 3.5576
[BP] GO:0009892 negative regulation of metabolic process APEX1, APP, AURKB, BCL2, CNR1, CNR2, CSNK2A1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, FABP4, HTR1B, HTR1E, HTR2B, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PRKCA, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, XDH 3.55294
[BP] GO:0031324 negative regulation of cellular metabolic process APEX1, APP, AURKB, BCL2, CNR1, CSNK2A1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, FABP4, HTR1B, HTR1E, HTR2B, IGF1R, MET, MMP12, MMP9, PIK3CA, PRKCA, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, XDH 3.53943
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade ALOX15, APP, HTR2A, HTR2B, HTR2C, KDR, PRKCA, SRC 3.49755
[BP] GO:0010511 None HTR2A, HTR2B, HTR2C 3.48965
[BP] GO:0051240 positive regulation of multicellular organismal process APP, AXL, BCL2, CA2, CNR1, CYP1B1, ESRRB, F3, HTR2A, HTR2B, JAK2, KDR, KIT, MET, MMP12, MMP9, PIM1, PRKCA, PTGS2, SRC, TERT 3.45649
[BP] GO:0043271 negative regulation of ion transport BCL2, CNR1, HTR1B, HTR2A, KCNH2, MMP9, PTGS2 3.44672
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.40152
[BP] GO:0032845 None BCL2, HTR2A, HTR2B, HTR2C, SRC, TNKS, TNKS2 3.3902
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ALOX15, APP, HTR2A, HTR2B, HTR2C, KDR, PRKCA, PTPN1, SRC 3.38818
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APEX1, APP, CYP1A1, CYP1B1, ESR1, FLT3, PTGS2, RORC, SRC 3.38818
[BP] GO:0003013 None HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2, SRC 3.38818
[BP] GO:0032496 response to lipopolysaccharide ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, JAK2, PTGS2, SRC 3.35398
[BP] GO:2000021 regulation of ion homeostasis BCL2, CA2, CA7, HTR2A, HTR2B, HTR2C, KDR, SRC 3.34563
[BP] GO:0016477 cell migration AXL, CNR2, CYP1B1, FUT7, HTR2B, HTR6, JAK2, KDR, KIT, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, SRC 3.3444
[BP] GO:0051896 regulation of protein kinase B signaling AXL, F3, KIT, MET, PIK3CA, PIK3CB, SRC, XDH 3.30379
[BP] GO:0019216 regulation of lipid metabolic process CNR1, CYP1A1, FLT3, HTR2A, HTR2B, HTR2C, KIT, PTGS2, RORC, SRC 3.27207
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, F3, KIT, MET, PIK3CA, PIK3CB, SRC 3.2552
[BP] GO:0050794 regulation of cellular process ACHE, ADORA3, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA7, CA9, CDC25B, CDK6, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DNMT1, DYRK1A, EBP, ESR1, ESR2, ESRRA, ESRRB, F3, FABP4, FLT3, GLO1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, JAK2, KCNH2, KDR, KIT, MET, MGLL, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PRKCA, PTGS1, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 3.20713
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, FLT3, HSD11B2, HTR1B, PTGS2, SRC 3.20713
[BP] GO:0048545 response to steroid hormone ALPL, BCL2, CA2, FLT3, HSD11B2, HTR1B, PTGS2, SRC 3.20072
[BP] GO:0007188 None CNR1, HTR1A, HTR1B, HTR1D, HTR1E, HTR5A, HTR7 3.19263
[BP] GO:0034502 protein localization to chromosome AURKB, ESR1, TERT, TNKS, TNKS2 3.18602
[BP] GO:0044093 positive regulation of molecular function ABCB1, APP, AURKB, BCL2, CDC25B, ESR1, ESR2, F3, FLT3, HTR2A, HTR2B, JAK2, KIT, MET, MMP9, PIK3CA, PIK3CB, PTPN1, SRC, TERT, TNKS, XDH 3.18349
[BP] GO:0071073 None HTR2A, HTR2B, HTR2C 3.16225
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, APP, CNR1, CNR2, DNMT1, FLT3, HSD11B2, HTR1B, IGF1R, MMP2, PTGS2, SRC, TYR 3.16018
[BP] GO:0002237 response to molecule of bacterial origin ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, JAK2, PTGS2, SRC 3.15616
[BP] GO:0022414 reproductive process AKR1B1, ALPL, APP, AXL, BCL2, CDC25B, CNR1, CYP19A1, CYP1A1, ESR1, ESRRB, HSD11B2, HSD17B2, KIT, MMP2, MMP9, PTGS2, SRC, TOP2A 3.13737
[BP] GO:0048015 phosphatidylinositol-mediated signaling HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB 3.12838
[BP] GO:0099536 None CNR1, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 3.12838
[BP] GO:0099537 None CNR1, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 3.12838
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, CNR1, PIK3CB, PTGS2, TNKS, TNKS2 3.12469
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, DYRK1A, FLT3, IGF1R, JAK2, KDR, KIT, MET, PRKCA, SRC, TNKS, TOP2A 3.12469
[BP] GO:0006950 response to stress ACHE, ADORA3, AKR1B1, ALOX15, APEX1, APP, AXL, BCL2, CA2, CA9, CNR2, CYP1A1, CYP1A2, CYP1B1, HSD11B2, HTR1A, HTR2C, JAK2, KIT, MGLL, MMP2, MMP9, PIK3CA, PIK3CB, PTGS1, PTGS2, PTPN1, SRC, TERT, TOP2A 3.12422
[BP] GO:0050789 regulation of biological process ABCB1, ACHE, ADORA3, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA7, CA9, CDC25B, CDK6, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, EBP, ESR1, ESR2, ESRRA, ESRRB, F3, FABP4, FLT3, GLO1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, JAK2, KCNH2, KDR, KIT, MET, MGLL, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PRKCA, PTGS1, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 3.08323
[BP] GO:0080090 regulation of primary metabolic process ADORA3, ALOX15, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CNR1, CSNK2A1, CYP1A1, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FABP4, FLT3, GLO1, HTR1A, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, JAK2, KDR, KIT, MET, MMP12, MMP9, PIK3CA, PIK3CB, PIM1, PRKCA, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 3.08323
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, BCL2, CYP1B1, SRC 3.08323
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC 3.08323
[BP] GO:0009628 response to abiotic stimulus AKR1B1, APP, AURKB, BCL2, CA2, CYP1A1, HSD11B2, HTR1B, HTR2A, HTR2B, KIT, MMP2, PTGS2, SRC, TERT, TYR 3.07942
[BP] GO:0007568 aging APEX1, AURKB, BCL2, CNR1, CYP1A1, HTR2A, PTGS2, TERT 3.07192
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, CNR2, HTR1B, HTR2A, PTGS2 3.04927
[BP] GO:0048017 inositol lipid-mediated signaling HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB 3.04927
[BP] GO:2001225 regulation of chloride transport ABCB1, CA2, CA7 3.04671
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.04671
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, JAK2, RORC, SRC 3.04613
[BP] GO:0003008 None AKR1B1, APP, BCL2, CNR1, CNR2, CYP1B1, HSD11B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, KCNH2, KIT, PIK3CA, PTGS2, SRC, TYR 3.03797
[BP] GO:0051094 positive regulation of developmental process APP, AXL, BCL2, CA2, CNR1, CYP1B1, ESRRB, F3, HTR2A, HTR2C, JAK2, KDR, KIT, PIM1, PRKCA, PTGS2, SRC, TERT 3.01858
[BP] GO:0002682 regulation of immune system process ALOX15, APP, AXL, BCL2, CA2, CDK6, CNR1, CNR2, CYP19A1, ESR1, ESRRA, JAK2, KIT, MMP12, MMP2, PIK3CA, PIK3CB, PRKCA, PTPN1, SRC 2.99974
[BP] GO:0040011 locomotion AXL, CNR2, CYP1B1, FUT7, HTR2B, HTR6, JAK2, KDR, KIT, MET, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, SRC 2.98482
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, NQO2, PTGS1, RORC 2.97254
[BP] GO:0065009 regulation of molecular function ABCB1, ADORA3, APP, AURKB, BCL2, CDC25B, CNR1, CNR2, CSNK2A1, CYP1B1, ESR1, ESR2, F3, FABP4, FLT3, HTR2A, HTR2B, IGF1R, JAK2, KIT, MET, MMP9, PIK3CA, PIK3CB, PIM1, PRKCA, PTGS2, PTPN1, SRC, TERT, TNKS, XDH 2.9453
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, BCL2, CYP1B1, MMP9, SRC 2.9453
[BP] GO:0046486 glycerolipid metabolic process ACHE, ALOX15, ALPI, CSNK2A1, FABP4, KIT, MET, MGLL, PIK3CA, PIK3CB 2.94462
[BP] GO:0048870 cell motility AXL, CNR2, CYP1B1, FUT7, HTR2B, HTR6, JAK2, KDR, KIT, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, SRC 2.93882
[BP] GO:1904018 positive regulation of vasculature development CYP1B1, F3, KDR, KIT, PRKCA, PTGS2, TERT 2.93412
[BP] GO:0002320 lymphoid progenitor cell differentiation BCL2, FLT3, KIT 2.93412
[BP] GO:0010863 positive regulation of phospholipase C activity ESR1, HTR2A, HTR2B, KIT 2.93412
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA3, ALOX15, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CNR1, CSNK2A1, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FABP4, FLT3, GLO1, HTR1A, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, JAK2, KDR, KIT, MET, MMP12, MMP9, PIK3CA, PIK3CB, PIM1, PRKCA, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 2.89748
[BP] GO:0051130 positive regulation of cellular component organization ALOX15, APP, AURKB, AXL, BCL2, CNR1, DNMT1, ESR1, IGF1R, KDR, KIT, MET, MMP1, MMP9, SRC, TNKS, TNKS2 2.87795
[BP] GO:1901698 response to nitrogen compound AKR1B1, APEX1, APP, CNR1, CNR2, DNMT1, FLT3, HSD11B2, HTR1B, IGF1R, MMP2, PTGS2, SRC, TYR 2.85166
[BP] GO:0043269 regulation of ion transport ABCB1, APP, BCL2, CA2, CA7, CNR1, HTR1A, HTR1B, HTR2A, KCNH2, MMP9, PTGS2 2.84587
[BP] GO:0048010 vascular endothelial growth factor receptor signaling pathway AXL, KDR, PIK3CA, PIK3CB, SRC 2.83626
[BP] GO:0007208 None HTR2A, HTR2C 2.80388
[BP] GO:0009115 None AOX1, XDH 2.80388
[BP] GO:1900274 regulation of phospholipase C activity ESR1, HTR2A, HTR2B, KIT 2.8011
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PRKCA, PTGS2, SRC 2.77832
[BP] GO:0043405 regulation of MAP kinase activity FLT3, HTR2A, HTR2B, IGF1R, JAK2, KIT, PIK3CB, PTPN1, SRC 2.76167
[BP] GO:0010810 regulation of cell-substrate adhesion ALOX15, BCL2, CDK6, JAK2, KDR, PIK3CB, SRC 2.76167
[BP] GO:0046456 icosanoid biosynthetic process ALOX15, ALOX5, PTGS1, PTGS2 2.75909
[BP] GO:0002521 leukocyte differentiation AXL, BCL2, FLT3, FUT7, GLO1, KIT, MMP9, RORC 2.74957
[BP] GO:0051098 regulation of binding APP, AURKB, BCL2, JAK2, MET, MMP9, SRC, TERT, TNKS 2.73661
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.73047
[BP] GO:0043406 positive regulation of MAP kinase activity FLT3, HTR2A, HTR2B, JAK2, KIT, PIK3CB, PTPN1, SRC 2.71953
[BP] GO:0046427 positive regulation of JAK-STAT cascade AKR1B1, CYP1B1, FLT3, JAK2, KIT 2.71953
[BP] GO:0048869 cellular developmental process ACHE, ALPL, APP, AXL, BCL2, CDC25B, CDK6, CYP1A1, ESR1, ESRRB, FABP4, FLT3, FUT7, GBA2, GLO1, HTR2B, JAK2, KDR, KIT, MET, MMP2, MMP9, PTGS2, RORC, SRC, TERT, TOP2A 2.71953
[BP] GO:0006954 inflammatory response ADORA3, ALOX15, AXL, CNR2, KIT, MGLL, PIK3CA, PIK3CB, PTGS1, PTGS2 2.7133
[BP] GO:0018107 peptidyl-threonine phosphorylation BCL2, CSNK2A1, DYRK1A, PRKCA, TNKS 2.69614
[BP] GO:1904894 positive regulation of STAT cascade AKR1B1, CYP1B1, FLT3, JAK2, KIT 2.67076
[BP] GO:0098771 inorganic ion homeostasis APP, BCL2, CA12, CA2, CA7, ESR1, HTR2A, HTR2B, HTR2C, JAK2, KCNH2, PIK3CB 2.64791
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.63913
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA3, ALOX15, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FABP4, FLT3, GLO1, HTR1A, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, JAK2, KDR, KIT, MET, MMP12, MMP9, PIK3CA, PIK3CB, PIM1, PRKCA, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 2.56635
[BP] GO:0032103 positive regulation of response to external stimulus CNR1, F3, FABP4, JAK2, KDR, MET, PRKCA, PTGS2 2.56269
[BP] GO:0006928 movement of cell or subcellular component APP, AXL, CNR2, CYP1B1, FUT7, HTR2B, HTR6, JAK2, KDR, KIT, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, SRC 2.55702
[BP] GO:1901989 None APEX1, APP, CDC25B, CYP1A1, TERT 2.55241
[BP] GO:0070198 None TERT, TNKS, TNKS2 2.55241
[BP] GO:0043393 regulation of protein binding APP, AURKB, BCL2, MET, MMP9, SRC, TERT 2.5508
[BP] GO:0007346 regulation of mitotic cell cycle APEX1, APP, AURKB, BCL2, CDC25B, CDK6, CYP1A1, PIM1, PRKCA, TERT, TNKS, TOP2A 2.5508
[BP] GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process CSNK2A1, F3, JAK2, MMP9, PTGS2, SRC, XDH 2.53886
[BP] GO:0006952 defense response ADORA3, ALOX15, APP, AXL, BCL2, CNR2, HTR1A, HTR2C, JAK2, KIT, MGLL, PIK3CA, PIK3CB, PTGS1, PTGS2, SRC 2.53763
[BP] GO:0009891 positive regulation of biosynthetic process APP, AURKB, ESR1, ESR2, ESRRA, ESRRB, HTR2A, HTR2B, HTR2C, IGF1R, JAK2, KDR, MET, MMP12, PTGS2, RORC, SRC, TERT, TNKS, TNKS2, TOP2A 2.53732
[BP] GO:0018210 peptidyl-threonine modification BCL2, CSNK2A1, DYRK1A, PRKCA, TNKS 2.53731
[BP] GO:0035556 intracellular signal transduction AKR1B1, AXL, BCL2, CYP1B1, DNMT1, HTR2A, HTR2B, HTR5A, IGF1R, JAK2, KCNH2, KDR, KIT, MET, PIK3CA, PIK3CB, PRKCA, PTPN1, SRC 2.53694
[BP] GO:0051338 regulation of transferase activity APP, AURKB, CDC25B, FABP4, FLT3, HTR2A, HTR2B, IGF1R, JAK2, KIT, PIK3CA, PIK3CB, PTPN1, SRC, TNKS 2.49759
[BP] GO:0050801 ion homeostasis APP, BCL2, CA12, CA2, CA7, ESR1, HTR2A, HTR2B, HTR2C, JAK2, KCNH2, PIK3CB 2.49759
[BP] GO:0050999 None CNR1, CNR2, HTR2B, TERT 2.49759
[BP] GO:2000811 negative regulation of anoikis BCL2, PIK3CA, SRC 2.48603
[BP] GO:0071071 None HTR2A, HTR2B, HTR2C 2.48603
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.48603
[BP] GO:0019372 lipoxygenase pathway ALOX15, ALOX5, PTGS2 2.48603
[BP] GO:0032101 regulation of response to external stimulus CNR1, CNR2, CYP19A1, ESR1, F3, FABP4, JAK2, KDR, MET, MGLL, MMP12, PRKCA, PTGS2 2.48603
[BP] GO:0045931 positive regulation of mitotic cell cycle APEX1, APP, CDC25B, CYP1A1, PRKCA, TERT 2.48603
[BP] GO:0009056 catabolic process ACHE, AKR1B10, AOX1, AURKB, BACE1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP4, FUT7, GBA2, MGLL, MMP1, MMP12, MMP2, MMP9, PIK3CB, SRC, XDH 2.46939
[BP] GO:0045859 regulation of protein kinase activity APP, CDC25B, FABP4, FLT3, HTR2A, HTR2B, IGF1R, JAK2, KIT, PIK3CA, PIK3CB, PTPN1, SRC 2.45813
[BP] GO:0007268 None HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 2.45813
[BP] GO:0098916 None HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 2.45813
[BP] GO:0010648 negative regulation of cell communication ACHE, BCL2, CNR2, DYRK1A, ESR1, ESR2, HTR1B, HTR2A, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, SRC, TERT, XDH 2.45508
[BP] GO:0043085 positive regulation of catalytic activity APP, AURKB, BCL2, CDC25B, ESR1, F3, FLT3, HTR2A, HTR2B, JAK2, KIT, PIK3CA, PIK3CB, PTPN1, SRC, TERT, TNKS, XDH 2.44361
[BP] GO:0023057 negative regulation of signaling ACHE, BCL2, CNR2, DYRK1A, ESR1, ESR2, HTR1B, HTR2A, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, SRC, TERT, XDH 2.44361
[BP] GO:1903530 regulation of secretion by cell ACHE, CNR1, CYP19A1, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, JAK2, MMP12, PRKCA, SRC 2.44309
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APEX1, APP, DNMT1, ESR1, FLT3, HTR1B, IGF1R, KIT, MMP2, PTGS2, SRC 2.43838
[BP] GO:0071248 cellular response to metal ion ALOX15, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 2.43838
[BP] GO:0051347 positive regulation of transferase activity AURKB, CDC25B, FLT3, HTR2A, HTR2B, JAK2, KIT, PIK3CA, PIK3CB, PTPN1, SRC, TNKS 2.4338
[BP] GO:0006631 fatty acid metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, MGLL, PTGS1, PTGS2 2.4338
[BP] GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress BCL2, CYP1B1, JAK2 2.43254
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.43254
[BP] GO:0032787 None ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, GBA2, GLO1, MGLL, PTGS1, PTGS2 2.42825
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation IGF1R, JAK2, KDR, SRC 2.42221
[BP] GO:0050793 regulation of developmental process APP, AXL, BCL2, CA2, CDK6, CNR1, CYP1B1, ESR1, ESRRA, ESRRB, F3, HTR2A, HTR2C, JAK2, KDR, KIT, PIK3CA, PIM1, PRKCA, PTGS2, RORC, SRC, TERT, TNKS2, XDH 2.42181
[BP] GO:0046110 None AOX1, XDH 2.42181
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.42181
[BP] GO:0006939 None HTR1D, HTR2A, HTR2B, HTR7 2.39476
[BP] GO:0044267 cellular protein metabolic process ALPI, ALPL, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CDK6, CSNK2A1, DYRK1A, ESR1, FLT3, FUT7, HTR2B, IGF1R, JAK2, KCNH2, KDR, KIT, MET, MMP1, MMP2, PIK3CA, PIM1, PRKCA, PTPN1, SRC, TNKS, TNKS2, TOP2A 2.39435
[BP] GO:0016137 None AKR1B1, AKR1B10, GBA2 2.36868
[BP] GO:0045766 positive regulation of angiogenesis CYP1B1, F3, KDR, PRKCA, PTGS2, TERT 2.36671
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, MMP9, PTGS2, PTPN1, SRC 2.36671
[BP] GO:0010518 positive regulation of phospholipase activity ESR1, HTR2A, HTR2B, KIT 2.36671
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APEX1, APP, DNMT1, HTR1B, IGF1R, MMP2, PTGS2, SRC 2.35537
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, ADORA3, ALOX15, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CDK6, CSNK2A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FABP4, FLT3, GLO1, HTR2A, HTR2B, HTR2C, IGF1R, JAK2, KDR, KIT, MET, MMP12, MMP9, PIK3CA, PIK3CB, PIM1, PRKCA, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 2.33004
[BP] GO:0003006 developmental process involved in reproduction ALPL, AXL, BCL2, CDC25B, CYP19A1, ESR1, ESRRB, HSD17B2, KIT, PTGS2, SRC 2.32174
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.30652
[BP] GO:0050730 None APP, FLT3, HTR2A, JAK2, KIT, PTPN1, SRC 2.2987
[BP] GO:0043065 positive regulation of apoptotic process BCL2, CNR1, CYP1B1, F3, JAK2, MMP9, PIK3CB, PTGS2, SRC, TOP2A, XDH 2.27546
[BP] GO:0022900 electron transport chain AKR1B1, AOX1, CYP19A1, CYP1A2, NQO2, XDH 2.25963
[BP] GO:2000116 regulation of cysteine-type endopeptidase activity CSNK2A1, F3, JAK2, MMP9, PTGS2, SRC, XDH 2.24547
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.24547
[BP] GO:0043068 positive regulation of programmed cell death BCL2, CNR1, CYP1B1, F3, JAK2, MMP9, PIK3CB, PTGS2, SRC, TOP2A, XDH 2.24344
[BP] GO:0048585 negative regulation of response to stimulus ALOX15, BCL2, CDK6, CNR1, CNR2, CYP19A1, DYRK1A, ESR1, ESR2, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, SRC, TERT, XDH 2.24344
[BP] GO:0051050 positive regulation of transport ABCB1, ACHE, APP, AXL, BCL2, CA2, CYP19A1, HTR2B, JAK2, KCNH2, MMP12, PTGS2, SRC, TERT 2.23013
[BP] GO:0018105 peptidyl-serine phosphorylation AURKB, BCL2, DYRK1A, PRKCA, SRC, TNKS 2.22405
[BP] GO:0031328 positive regulation of cellular biosynthetic process APP, AURKB, ESR1, ESR2, ESRRA, ESRRB, HTR2A, HTR2B, HTR2C, IGF1R, JAK2, MET, MMP12, PTGS2, RORC, SRC, TERT, TNKS, TNKS2, TOP2A 2.2222
[BP] GO:0001952 regulation of cell-matrix adhesion BCL2, CDK6, KDR, PIK3CB, SRC 2.2222
[BP] GO:0045860 positive regulation of protein kinase activity CDC25B, FLT3, HTR2A, HTR2B, JAK2, KIT, PIK3CA, PIK3CB, PTPN1, SRC 2.21503
[BP] GO:0043549 regulation of kinase activity APP, CDC25B, FABP4, FLT3, HTR2A, HTR2B, IGF1R, JAK2, KIT, PIK3CA, PIK3CB, PTPN1, SRC 2.20253
[BP] GO:0048534 hematopoietic or lymphoid organ development BCL2, EBP, FLT3, KDR, KIT, TYR 2.20113
[BP] GO:0051046 None ACHE, CNR1, CYP19A1, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, JAK2, MMP12, PRKCA, SRC 2.19894
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, DYRK1A, ESR1, IGF1R, MET, MMP9, PTGS2, PTPN1, SRC, XDH 2.19894
[BP] GO:0032768 None CNR1, CNR2, HTR2B, TERT 2.19747
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.19658
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.19658
[BP] GO:0019538 protein metabolic process ACHE, ALPI, ALPL, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CDK6, CSNK2A1, DYRK1A, ESR1, F3, FLT3, FUT7, HTR2B, IGF1R, JAK2, KCNH2, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIM1, PRKCA, PTPN1, SRC, TNKS, TNKS2, TOP2A 2.17762
[BP] GO:0046686 response to cadmium ion CYP1A2, KIT, MMP9, TERT 2.17419
[BP] GO:0055080 cation homeostasis APP, BCL2, CA2, CA7, ESR1, HTR2A, HTR2B, HTR2C, JAK2, KCNH2, PIK3CB 2.17419
[BP] GO:0070213 None TNKS, TNKS2 2.17419
[BP] GO:0006145 None AOX1, XDH 2.17419
[BP] GO:0038171 None CNR1, CNR2 2.17419
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.17419
[BP] GO:0014827 None HTR1D, HTR2B 2.17419
[BP] GO:0032268 regulation of cellular protein metabolic process ALOX15, APP, BCL2, CDC25B, CSNK2A1, DNMT1, DYRK1A, ESR1, F3, FABP4, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, JAK2, KDR, KIT, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SRC, XDH 2.1646
[BP] GO:1901342 regulation of vasculature development CYP1B1, F3, KDR, KIT, PRKCA, PTGS2, TERT, XDH 2.16353
[BP] GO:0071241 cellular response to inorganic substance ALOX15, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 2.15239
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.15118
[BP] GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation FLT3, HTR2A, JAK2, KIT, PTPN1, SRC 2.14082
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APEX1, APP, DNMT1, HTR1B, IGF1R, MMP2, PTGS2, SRC 2.13964
[BP] GO:0007154 None AXL, BCL2, CNR1, ESR2, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, PTGS2 2.12918
[BP] GO:0006650 glycerophospholipid metabolic process ACHE, ALOX15, ALPI, CSNK2A1, KIT, MET, PIK3CA, PIK3CB 2.12649
[BP] GO:0030168 platelet activation AXL, PIK3CA, PIK3CB, PRKCA, SRC 2.12006
[BP] GO:0009991 response to extracellular stimulus ALPL, AXL, BCL2, CNR1, CYP1A1, HSD11B2, PTGS2, SRC, TYR 2.11473
[BP] GO:0010517 regulation of phospholipase activity ESR1, HTR2A, HTR2B, KIT 2.10707
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic CNR1, HTR1B, HTR2A, PTGS2 2.10707
[BP] GO:2001251 None DNMT1, SRC, TNKS, TNKS2, TOP2A 2.10589
[BP] GO:2000209 regulation of anoikis BCL2, PIK3CA, SRC 2.10493
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.10493
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.08395
[BP] GO:0007610 None APP, BCL2, CNR1, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, KIT, PTGS2 2.08131
[BP] GO:0001525 angiogenesis CYP1B1, KDR, MMP2, PIK3CA, PIK3CB, PRKCA, PTGS2 2.07934
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, BCL2, CYP1A1, JAK2 2.07727
[BP] GO:0044283 None AKR1B1, ALOX15, ALOX5, CYP19A1, CYP1A1, EBP, MGLL, PTGS1, PTGS2 2.07416
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1 2.06213
[BP] GO:0001503 ossification ALOX15, ALPL, BCL2, MMP2, MMP9 2.06213
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.05883
[BP] GO:0055082 cellular chemical homeostasis APP, BCL2, CA2, CA7, ESR1, HTR2A, HTR2B, HTR2C, JAK2, PIK3CA, PIK3CB 2.05883
[BP] GO:0001666 response to hypoxia BCL2, CYP1A1, HSD11B2, MMP2, PTGS2, SRC, TERT 2.05556
[BP] GO:0043412 macromolecule modification ALPI, ALPL, APEX1, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DNMT1, DYRK1A, ESR1, FLT3, FUT7, HTR2B, IGF1R, JAK2, KCNH2, KDR, KIT, MET, PIK3CA, PIM1, PRKCA, PTPN1, SRC, TNKS, TNKS2, TOP2A 2.04727
[BP] GO:0033674 positive regulation of kinase activity CDC25B, FLT3, HTR2A, HTR2B, JAK2, KIT, PIK3CA, PIK3CB, PTPN1, SRC 2.0411
[BP] GO:0060193 positive regulation of lipase activity ESR1, HTR2A, HTR2B, KIT 2.0411
[BP] GO:0045597 positive regulation of cell differentiation APP, AXL, BCL2, CA2, CNR1, HTR2A, HTR2C, JAK2, KDR, KIT, PRKCA, PTGS2, TERT 2.02435
[BP] GO:0018209 peptidyl-serine modification AURKB, BCL2, DYRK1A, PRKCA, SRC, TNKS 2.02435
[BP] GO:0071902 positive regulation of protein serine/threonine kinase activity FLT3, HTR2A, HTR2B, JAK2, KIT, PIK3CB, PTPN1, SRC 2.02435
[BP] GO:0050900 leukocyte migration CNR2, FUT7, KIT, MMP1, MMP9, PIK3CA, PIK3CB, SRC 2.02435
[BP] GO:0046883 regulation of hormone secretion CNR1, CYP19A1, HTR1A, HTR2A, HTR2C, JAK2, PRKCA 2.02331
[BP] GO:0010942 positive regulation of cell death BCL2, CNR1, CYP1B1, F3, JAK2, MMP9, PIK3CB, PTGS2, SRC, TOP2A, XDH 2.02331
[BP] GO:0006464 cellular protein modification process ALPI, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DYRK1A, ESR1, FLT3, FUT7, HTR2B, IGF1R, JAK2, KCNH2, KDR, KIT, MET, PIK3CA, PIM1, PRKCA, PTPN1, SRC, TNKS, TNKS2, TOP2A 2.01444
[BP] GO:0036211 protein modification process ALPI, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DYRK1A, ESR1, FLT3, FUT7, HTR2B, IGF1R, JAK2, KCNH2, KDR, KIT, MET, PIK3CA, PIM1, PRKCA, PTPN1, SRC, TNKS, TNKS2, TOP2A 2.01444
[BP] GO:0045934 None APEX1, AURKB, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, FABP4, HTR1B, HTR1E, MMP12, PRKCA, RORC, SRC, TERT, TNKS, TNKS2 2.00613
[BP] GO:0006807 nitrogen compound metabolic process ACHE, AKR1B1, AKR1B10, ALPI, ALPL, AOX1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, FUT7, GBA2, GLO1, HTR1A, HTR2B, HTR2C, IGF1R, JAK2, KCNH2, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIM1, PRKCA, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 2.00613
[BP] GO:0046889 None HTR2A, HTR2B, HTR2C, PTGS2 2.00613
[BP] GO:2000573 positive regulation of DNA biosynthetic process AURKB, SRC, TNKS, TNKS2 2.00613
[BP] GO:0043696 None CDK6, ESRRB 2.00613
[BP] GO:0043697 None CDK6, ESRRB 2.00613
[BP] GO:0010641 None F3, SRC 2.00613
[BP] GO:0071502 None HTR1B, HTR2B 2.00613
[BP] GO:0002318 myeloid progenitor cell differentiation FLT3, KIT 2.00613
[BP] GO:0031329 regulation of cellular catabolic process APEX1, BCL2, CNR1, ESRRB, HTR2A, HTR2B, KDR, MET, PIK3CA, PIK3CB, PRKCA, PTPN1 2.00194
[BP] GO:0008150 biological_process ABCB1, ACHE, ADORA3, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPI, ALPL, AOX1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CDK6, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, EBP, ESR1, ESR2, ESRRA, ESRRB, F3, FABP4, FLT3, FUT7, GBA2, GLO1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, JAK2, KCNH2, KDR, KIT, MET, MGLL, MMP1, MMP12, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PRKCA, PTGS1, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 2.00194
[CC] GO:0005886 plasma membrane ABCB1, ACHE, ADORA3, ALOX15, ALPI, ALPL, APP, AXL, BACE1, CA12, CA14, CA2, CA4, CA9, CNR1, CNR2, CSNK2A1, ESR1, F3, FLT3, GBA2, GLO1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, JAK2, KCNH2, KDR, KIT, MET, MGLL, MMP2, PIK3CA, PIK3CB, PIM1, PRKCA, PTPN1, SRC, TERT 7.53996
[CC] GO:0016020 membrane ABCB1, ACHE, ADORA3, ALOX15, ALOX5, ALPI, ALPL, APP, AXL, BACE1, BCL2, CA12, CA14, CA2, CA4, CA9, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EBP, ESR1, F3, FLT3, FUT7, GBA2, GLO1, HSD11B1, HSD11B2, HSD17B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, JAK2, KCNH2, KDR, KIT, MET, MGLL, MMP2, PIK3CA, PIK3CB, PIM1, PRKCA, PTGS1, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, TYR 6.83755
[CC] GO:0044459 plasma membrane part ABCB1, ADORA3, ALOX15, APP, AXL, BACE1, CA2, CA4, CA9, CNR1, CNR2, EBP, F3, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, JAK2, KCNH2, KDR, KIT, MET, PTGS2, SRC 5.37968
[CC] GO:0031226 intrinsic component of plasma membrane ADORA3, APP, AXL, BACE1, CA4, CNR1, CNR2, EBP, F3, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET 5.37745
[CC] GO:0044425 membrane part ABCB1, ACHE, ADORA3, ALOX15, ALPI, ALPL, APP, AXL, BACE1, BCL2, CA12, CA14, CA2, CA4, CA9, CNR1, CNR2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EBP, ESR1, F3, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, JAK2, KCNH2, KDR, KIT, MET, MGLL, PIK3CA, PIK3CB, PTGS1, PTGS2, PTPN1, SRC, TYR 5.01289
[CC] GO:0005887 integral component of plasma membrane ADORA3, APP, AXL, BACE1, CNR1, CNR2, EBP, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET 4.52943
[CC] GO:0045121 membrane raft APP, BACE1, CNR1, HTR2A, JAK2, KDR, PTGS2, SRC 2.45038
[CC] GO:0098857 membrane microdomain APP, BACE1, CNR1, HTR2A, JAK2, KDR, PTGS2, SRC 2.43838
[CC] GO:0044432 endoplasmic reticulum part APP, BACE1, BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EBP, FLT3, GBA2, HSD11B1, HSD11B2, HSD17B2, MGLL, PTGS1, PTGS2, PTPN1 2.43763
[CC] GO:0044464 cell part ABCB1, ACHE, ADORA3, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPI, ALPL, AOX1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CDK6, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, EBP, ESR1, ESR2, ESRRA, ESRRB, F3, FABP4, FLT3, FUT7, GBA2, GLO1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, JAK2, KCNH2, KDR, KIT, MET, MGLL, MMP12, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PRKCA, PTGS1, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 2.39872
[CC] GO:0005783 None APEX1, APP, BCL2, CA4, CYP19A1, EBP, FLT3, GBA2, HTR5A, KDR, PRKCA, PTGS2, PTPN1, XDH 2.32207
[CC] GO:0044444 cytoplasmic part ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, APEX1, APP, AURKB, BACE1, BCL2, CA1, CA2, CA4, CA7, CDC25B, CDK6, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EBP, ESR1, ESR2, FABP4, FLT3, FUT7, GBA2, GLO1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR2A, HTR4, HTR5A, JAK2, KCNH2, KDR, KIT, MGLL, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PRKCA, PTGS1, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 2.09222
[CC] GO:0098589 membrane region APP, BACE1, CNR1, HTR2A, JAK2, KDR, PTGS2, SRC 2.00613
[MF] GO:0004993 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 16.0056
[MF] GO:0099589 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 16.0056
[MF] GO:0043176 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 16.0056
[MF] GO:0051378 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 16.0056
[MF] GO:0043167 ion binding ABCB1, ACHE, ALOX15, ALOX5, ALPI, ALPL, AOX1, APEX1, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FABP4, FLT3, GLO1, HSD17B1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, IGF1R, JAK2, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PRKCA, PTGS1, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 15.5911
[MF] GO:0046914 transition metal ion binding ALOX15, ALOX5, ALPI, AOX1, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, PIM1, PRKCA, PTPN1, RORC, TNKS, TYR, XDH 15.4584
[MF] GO:0099528 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 13.6738
[MF] GO:0003824 catalytic activity ABCB1, ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPI, ALPL, AOX1, APEX1, AURKB, AXL, BACE1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, EBP, F3, FLT3, FUT7, GBA2, GLO1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, JAK2, KCNH2, KDR, KIT, MET, MGLL, MMP1, MMP12, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PRKCA, PTGS1, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 13.1989
[MF] GO:0043169 cation binding ACHE, ALOX15, ALOX5, ALPI, ALPL, AOX1, APEX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, ESR1, ESR2, ESRRA, ESRRB, GLO1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, JAK2, KIT, MMP1, MMP12, MMP2, MMP9, NQO2, PIM1, PRKCA, PTGS1, PTGS2, PTPN1, RORC, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 11.9885
[MF] GO:0008227 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 11.7099
[MF] GO:0042165 neurotransmitter binding ACHE, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 10.4295
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 9.67672
[MF] GO:0070405 ammonium ion binding ACHE, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 9.02614
[MF] GO:0030594 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 8.75889
[MF] GO:0038023 signaling receptor activity ADORA3, AXL, CNR1, CNR2, EBP, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KCNH2, KDR, KIT, MET, RORC 8.46217
[MF] GO:0008270 zinc ion binding ALPI, CA1, CA12, CA2, CA4, CA7, CA9, DNMT1, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, PRKCA, PTPN1, RORC, TNKS 8.36493
[MF] GO:0060089 molecular transducer activity ADORA3, AXL, CDK6, CNR1, CNR2, EBP, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KCNH2, KDR, KIT, MET, RORC 7.78258
[MF] GO:0004872 receptor activity ADORA3, AXL, CNR1, CNR2, EBP, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KCNH2, KDR, KIT, MET, RORC 7.40525
[MF] GO:0008144 drug binding ABCB1, ACHE, AURKB, AXL, CDK6, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DYRK1A, FLT3, HTR1B, HTR2A, HTR2B, HTR2C, IGF1R, JAK2, KDR, KIT, MET, NQO2, PIK3CA, PIK3CB, PIM1, PRKCA, SRC, TOP2A 7.09966
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, NQO2, PTGS1, PTGS2, TYR, XDH 6.76715
[MF] GO:0004871 signal transducer activity ADORA3, AXL, CNR1, CNR2, EBP, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KCNH2, KDR, KIT, MET, RORC 6.56021
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.30054
[MF] GO:0046872 metal ion binding ALOX15, ALOX5, ALPI, ALPL, AOX1, APEX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, ESR1, ESR2, ESRRA, ESRRB, GLO1, JAK2, KIT, MMP1, MMP12, MMP2, MMP9, NQO2, PIM1, PRKCA, PTGS1, PTGS2, PTPN1, RORC, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 6.14432
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 5.87073
[MF] GO:0099600 transmembrane receptor activity ADORA3, AXL, CNR1, CNR2, EBP, F3, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MET 5.28871
[MF] GO:0004888 transmembrane signaling receptor activity ADORA3, AXL, CNR1, CNR2, EBP, F3, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MET 5.28871
[MF] GO:0004672 protein kinase activity AURKB, AXL, CDK6, CSNK2A1, DYRK1A, FLT3, IGF1R, JAK2, KCNH2, KDR, KIT, MET, PIK3CA, PIM1, PRKCA, SRC 5.18069
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CDK6, CSNK2A1, DYRK1A, FLT3, IGF1R, JAK2, KCNH2, KDR, KIT, MET, PIK3CA, PIK3CB, PIM1, PRKCA, SRC 4.91101
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, JAK2, PTGS1, PTGS2, SRC 4.71501
[MF] GO:0005496 steroid binding ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1, RORC 4.69542
[MF] GO:0043560 insulin receptor substrate binding IGF1R, JAK2, PIK3CA, PIK3CB 4.68376
[MF] GO:0004713 protein tyrosine kinase activity AXL, DYRK1A, FLT3, IGF1R, JAK2, KDR, KIT, MET, SRC 4.68267
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, GLO1 4.6283
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, XDH 4.54122
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, JAK2, PTGS1, PTGS2, SRC 4.51081
[MF] GO:0016301 kinase activity AURKB, AXL, CDK6, CSNK2A1, DYRK1A, FLT3, IGF1R, JAK2, KCNH2, KDR, KIT, MET, PIK3CA, PIK3CB, PIM1, PRKCA, SRC 4.44666
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B2, HSD17B1, JAK2, NQO2, PTGS1, PTGS2, SRC, XDH 4.44083
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, KIT, MET 4.30295
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CDK6, CSNK2A1, DYRK1A, FLT3, IGF1R, JAK2, KCNH2, KDR, KIT, MET, PIK3CA, PIK3CB, PIM1, PRKCA, SRC, TERT 4.18397
[MF] GO:0042802 identical protein binding ACHE, AOX1, APP, BCL2, CSNK2A1, DYRK1A, ESR1, ESR2, FLT3, IGF1R, JAK2, KCNH2, KDR, KIT, MET, MGLL, MMP9, NQO2, PTGS2, TERT, TOP2A, TYR, XDH 4.13481
[MF] GO:1901363 heterocyclic compound binding ABCB1, AOX1, APEX1, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, FLT3, HSD11B2, HSD17B1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, IGF1R, JAK2, KDR, KIT, MET, MMP12, NQO2, PIK3CA, PIK3CB, PIM1, PRKCA, PTGS1, PTGS2, PTPN1, RORC, SRC, TERT, TOP2A, XDH 4.12108
[MF] GO:0005506 iron ion binding ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, XDH 4.1049
[MF] GO:0097159 organic cyclic compound binding ABCB1, AOX1, APEX1, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, FLT3, HSD11B2, HSD17B1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, IGF1R, JAK2, KDR, KIT, MET, MMP12, NQO2, PIK3CA, PIK3CB, PIM1, PRKCA, PTGS1, PTGS2, PTPN1, RORC, SRC, TERT, TOP2A, XDH 4.02777
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, KIT, MET 3.76314
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, RORC 3.53943
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, RORC 3.53943
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.47293
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.27455
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.21234
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, TYR 3.20713
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, RORC 3.18602
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.11974
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, NQO2, XDH 3.08323
[MF] GO:0000166 nucleotide binding ABCB1, AOX1, AURKB, AXL, CDK6, CSNK2A1, DNMT1, DYRK1A, FLT3, HSD11B2, HSD17B1, IGF1R, JAK2, KDR, KIT, MET, NQO2, PIK3CA, PIK3CB, PIM1, PRKCA, SRC, TOP2A, XDH 2.97743
[MF] GO:1901265 nucleoside phosphate binding ABCB1, AOX1, AURKB, AXL, CDK6, CSNK2A1, DNMT1, DYRK1A, FLT3, HSD11B2, HSD17B1, IGF1R, JAK2, KDR, KIT, MET, NQO2, PIK3CA, PIK3CB, PIM1, PRKCA, SRC, TOP2A, XDH 2.97563
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, HSD11B1, HSD11B2, HSD17B1, HSD17B2 2.88084
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 2.80388
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.80388
[MF] GO:0003845 None HSD11B1, HSD11B2 2.80388
[MF] GO:0071886 None HTR2A, HTR2C 2.80388
[MF] GO:0004930 None ADORA3, CNR1, CNR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 2.60741
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.49759
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 2.46939
[MF] GO:0042803 protein homodimerization activity ACHE, AOX1, BCL2, FLT3, KCNH2, KIT, MGLL, NQO2, PTGS2, TERT, TOP2A, TYR, XDH 2.44361
[MF] GO:0036094 small molecule binding ABCB1, AOX1, AURKB, AXL, CDK6, CSNK2A1, DNMT1, DYRK1A, FABP4, FLT3, HSD11B2, HSD17B1, IGF1R, JAK2, KDR, KIT, MET, NQO2, PIK3CA, PIK3CB, PIM1, PRKCA, SRC, TOP2A, XDH 2.43647
[MF] GO:0035173 histone kinase activity AURKB, JAK2, PRKCA 2.43254
[MF] GO:0050473 arachidonate 15-lipoxygenase activity ALOX15, PTGS2 2.42181
[MF] GO:0004949 None CNR1, CNR2 2.42181
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, TYR 2.36671
[MF] GO:0005524 ATP binding ABCB1, AURKB, AXL, CDK6, CSNK2A1, DYRK1A, FLT3, IGF1R, JAK2, KDR, KIT, MET, PIK3CA, PIK3CB, PIM1, PRKCA, SRC, TOP2A 2.28445
[MF] GO:0140096 catalytic activity, acting on a protein AURKB, AXL, BACE1, CDC25B, CDK6, CSNK2A1, DYRK1A, F3, FLT3, IGF1R, JAK2, KCNH2, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIM1, PRKCA, PTPN1, SRC 2.24344
[MF] GO:0032559 adenyl ribonucleotide binding ABCB1, AURKB, AXL, CDK6, CSNK2A1, DYRK1A, FLT3, IGF1R, JAK2, KDR, KIT, MET, PIK3CA, PIK3CB, PIM1, PRKCA, SRC, TOP2A 2.17827
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.17419
[MF] GO:0030554 adenyl nucleotide binding ABCB1, AURKB, AXL, CDK6, CSNK2A1, DYRK1A, FLT3, IGF1R, JAK2, KDR, KIT, MET, PIK3CA, PIK3CB, PIM1, PRKCA, SRC, TOP2A 2.15552
[MF] GO:0043168 anion binding ABCB1, ALOX15, AOX1, APP, AURKB, AXL, CDK6, CSNK2A1, DYRK1A, F3, FABP4, FLT3, HSD17B1, IGF1R, JAK2, KDR, KIT, MET, NQO2, PIK3CA, PIK3CB, PIM1, PRKCA, SRC, TOP2A, XDH 2.12006
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.00613


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Serotonergic synapse_Homo sapiens_hsa04726 APP, HTR1E, ALOX15, HTR1D, HTR2B, HTR1A, HTR1B, HTR2C, PRKCA, HTR2A, PTGS2, HTR5A, HTR4, PTGS1, HTR6, HTR7, ALOX5 19.0428
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 HTR1E, HTR1D, HTR2B, HTR1A, HTR1B, HTR2C, HTR2A, HTR5A, HTR4, HTR6, HTR7, CNR2, CNR1, ADORA3 9.0655
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 8.7387
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 10.432
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 8.2952
Metabolic pathways_Homo sapiens_hsa01100 DNMT1, ALOX15, AKR1B1, PTGS2, TYR, GBA2, CYP19A1, PTGS1, HSD11B1, EBP, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, ALPI, XDH, MGLL 6.5971
Pathways in cancer_Homo sapiens_hsa05200 FLT3, MMP1, MMP2, PRKCA, PIK3CB, PTGS2, MMP9, IGF1R, CDK6, PIK3CA, KIT, BCL2, MET 6.5024
MicroRNAs in cancer_Homo sapiens_hsa05206 DNMT1, CDK6, ABCB1, PIK3CA, BCL2, PIM1, CYP1B1, PRKCA, PTGS2, MMP9, MET, CDC25B 6.763
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 PIK3CA, MMP2, BCL2, PIM1, PRKCA, PIK3CB, JAK2, F3 6.5421
Proteoglycans in cancer_Homo sapiens_hsa05205 PIK3CA, SRC, MMP2, KDR, PRKCA, PIK3CB, MMP9, MET, ESR1, IGF1R 6.4915
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 PIK3CA, SRC, HTR2B, HTR2C, PRKCA, PIK3CB, HTR2A 5.4969
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PIK3CA, PIK3CB, PTGS2, MGLL, PTGS1 5.6176
Estrogen signaling pathway_Homo sapiens_hsa04915 PIK3CA, SRC, MMP2, PIK3CB, MMP9, ESR1, ESR2 5.4969
Rap1 signaling pathway_Homo sapiens_hsa04015 PIK3CA, SRC, CNR1, KIT, KDR, PRKCA, PIK3CB, MET, IGF1R 5.4069
VEGF signaling pathway_Homo sapiens_hsa04370 PIK3CA, SRC, KDR, PRKCA, PIK3CB, PTGS2 5.4969
Calcium signaling pathway_Homo sapiens_hsa04020 HTR6, HTR7, HTR2B, HTR2C, PRKCA, HTR2A, HTR5A, HTR4 4.9278
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CDK6, PIK3CA, KIT, KDR, BCL2, PRKCA, PIK3CB, JAK2, MET, IGF1R 4.6651
Prolactin signaling pathway_Homo sapiens_hsa04917 PIK3CA, SRC, PIK3CB, JAK2, ESR1, ESR2 5.1222
cAMP signaling pathway_Homo sapiens_hsa04024 HTR6, PIK3CA, HTR1E, HTR1D, HTR1A, HTR1B, PIK3CB, HTR4 4.6496
Focal adhesion_Homo sapiens_hsa04510 PIK3CA, SRC, KDR, BCL2, PRKCA, PIK3CB, MET, IGF1R 4.6236
Hepatitis B_Homo sapiens_hsa05161 CDK6, PIK3CA, SRC, BCL2, PRKCA, PIK3CB, MMP9 4.5538
Ras signaling pathway_Homo sapiens_hsa04014 HTR7, PIK3CA, KIT, KDR, PRKCA, PIK3CB, MET, IGF1R 4.3102
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, PIK3CA, BCL2, PRKCA, PIK3CB, JAK2 4.1959
Acute myeloid leukemia_Homo sapiens_hsa05221 PIK3CA, FLT3, KIT, PIM1, PIK3CB 4.4229
Glioma_Homo sapiens_hsa05214 CDK6, PIK3CA, PRKCA, PIK3CB, IGF1R 4.1952
Melanoma_Homo sapiens_hsa05218 CDK6, PIK3CA, PIK3CB, MET, IGF1R 4.0399
Central carbon metabolism in cancer_Homo sapiens_hsa05230 PIK3CA, FLT3, KIT, PIK3CB, MET 4.1473
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MET, IGF1R 3.9678
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIK3CA, BCL2, PIM1, AOX1, PIK3CB, JAK2 3.4925
Small cell lung cancer_Homo sapiens_hsa05222 CDK6, PIK3CA, BCL2, PIK3CB, PTGS2 3.7219
HIF-1 signaling pathway_Homo sapiens_hsa04066 PIK3CA, BCL2, PRKCA, PIK3CB, IGF1R 3.3846
Gap junction_Homo sapiens_hsa04540 SRC, HTR2B, HTR2C, PRKCA, HTR2A 3.6868
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP1A2, CYP1A1, CYP1B1, PTGS2 3.7964
Toxoplasmosis_Homo sapiens_hsa05145 PIK3CA, ALOX5, BCL2, PIK3CB, JAK2 3.1624
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 PIK3CA, SRC, PRKCA, PIK3CB, ESR1 3.1624
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PIK3CA, MMP2, PRKCA, PIK3CB, MMP9 3.1624
Sphingolipid signaling pathway_Homo sapiens_hsa04071 PIK3CA, ADORA3, BCL2, PRKCA, PIK3CB 3.1387
Measles_Homo sapiens_hsa05162 CDK6, CSNK2A1, PIK3CA, PIK3CB, JAK2 2.9161
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 PIK3CA, ESRRB, PIK3CB, JAK2, IGF1R 2.8486
Non-small cell lung cancer_Homo sapiens_hsa05223 CDK6, PIK3CA, PRKCA, PIK3CB 3.3214
Oxytocin signaling pathway_Homo sapiens_hsa04921 PIK3CA, SRC, PRKCA, PIK3CB, PTGS2 2.6728
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2, PIK3CA, PRKCA, PIK3CB 3.841
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, ALOX15, PTGS2, PTGS1 3.1624
Taste transduction_Homo sapiens_hsa04742 HTR1E, HTR1D, HTR1A, HTR1B 2.7739
Prostate cancer_Homo sapiens_hsa05215 PIK3CA, BCL2, PIK3CB, IGF1R 2.6767
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PIK3CA, PIK3CB, CDC25B, IGF1R 2.5367
ErbB signaling pathway_Homo sapiens_hsa04012 PIK3CA, SRC, PRKCA, PIK3CB 2.7053
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1 3.8114
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 3.7964
TNF signaling pathway_Homo sapiens_hsa04668 PIK3CA, PIK3CB, PTGS2, MMP9 2.3665
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP1A2, CYP1A1, CYP1B1 2.9492
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 CNR1, PRKCA, PTGS2, MGLL 2.4961
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 PIK3CA, SRC, PIK3CB, MET 2.8582
Platelet activation_Homo sapiens_hsa04611 PIK3CA, SRC, PIK3CB, PTGS1 2.2172
Endocytosis_Homo sapiens_hsa04144 SRC, KIT, KDR, MET, IGF1R 1.8681
Phospholipase D signaling pathway_Homo sapiens_hsa04072 PIK3CA, KIT, PRKCA, PIK3CB 2.022
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 PIK3CA, BCL2, PRKCA, PIK3CB 1.9927
Influenza A_Homo sapiens_hsa05164 PIK3CA, PRKCA, PIK3CB, JAK2 1.7625
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.7496
Chemokine signaling pathway_Homo sapiens_hsa04062 PIK3CA, SRC, PIK3CB, JAK2 1.7151
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, PIK3CA, BCL2, PIK3CB 1.6326
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, PRKCA 1.759
Viral carcinogenesis_Homo sapiens_hsa05203 CDK6, PIK3CA, SRC, PIK3CB 1.6211
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PIK3CA, PRKCA, PIK3CB 1.7508
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 PIK3CA, PRKCA, PIK3CB 2.0614
Chronic myeloid leukemia_Homo sapiens_hsa05220 CDK6, PIK3CA, PIK3CB 1.9927
mTOR signaling pathway_Homo sapiens_hsa04150 PIK3CA, PRKCA, PIK3CB 2.1735
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 PIK3CA, PIK3CB, IGF1R 2.1081
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 PIK3CA, PIK3CB, IGF1R 1.7496
Purine metabolism_Homo sapiens_hsa00230 XDH 0.2698
Pancreatic cancer_Homo sapiens_hsa05212 CDK6, PIK3CA, PIK3CB 2.0913
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.2791
Melanogenesis_Homo sapiens_hsa04916 KIT, PRKCA, TYR 1.7036
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2, PTGS2 1.7508
Colorectal cancer_Homo sapiens_hsa05210 PIK3CA, BCL2, PIK3CB 2.1401
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PIK3CA, PRKCA, PIK3CB 1.7151
Renal cell carcinoma_Homo sapiens_hsa05211 PIK3CA, PIK3CB, MET 2.0913
Amoebiasis_Homo sapiens_hsa05146 PIK3CA, PRKCA, PIK3CB 1.7036
Choline metabolism in cancer_Homo sapiens_hsa05231 PIK3CA, PRKCA, PIK3CB 1.697
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PIK3CA, PIK3CB 1.628
Neurotrophin signaling pathway_Homo sapiens_hsa04722 PIK3CA, BCL2, PIK3CB 1.5262
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KIT, KDR, MET 1.3207
AMPK signaling pathway_Homo sapiens_hsa04152 PIK3CA, PIK3CB, IGF1R 1.4981
FoxO signaling pathway_Homo sapiens_hsa04068 PIK3CA, PIK3CB, IGF1R 1.4323
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 PIK3CA, PRKCA, PIK3CB 1.42
Apoptosis_Homo sapiens_hsa04210 PIK3CA, BCL2, PIK3CB 1.3969
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1 2.0962
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1, MGLL 2.1868
Axon guidance_Homo sapiens_hsa04360 MET 0.3627
Dopaminergic synapse_Homo sapiens_hsa04728 PRKCA 0.3602
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.3706
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, PIK3CA, PIK3CB 1.4004
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC, PRKCA 1.4004
Vascular smooth muscle contraction_Homo sapiens_hsa04270 PRKCA 0.3761
MAPK signaling pathway_Homo sapiens_hsa04010 PRKCA, CDC25B 0.479
Glutamatergic synapse_Homo sapiens_hsa04724 PRKCA 0.3906
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 PIK3CA, SRC, PIK3CB 1.0076
HTLV-I infection_Homo sapiens_hsa05166 PIK3CA, TERT, PIK3CB 0.8459
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 PIK3CA, ADORA3, PIK3CB 1.2311
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1, JAK2 0.6377
Alzheimer's disease_Homo sapiens_hsa05010 BACE1, APP 0.6805
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2, JAK2 1.1861
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PIK3CA, PIK3CB 0.744
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1, PRKCA 0.7804
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4508
Osteoclast differentiation_Homo sapiens_hsa04380 PIK3CA, PIK3CB 0.8153
Hepatitis C_Homo sapiens_hsa05160 PIK3CA, PIK3CB 0.8133
Cell cycle_Homo sapiens_hsa04110 CDK6, CDC25B 0.8465
Circadian entrainment_Homo sapiens_hsa04713 PRKCA 0.4508
Morphine addiction_Homo sapiens_hsa05032 PRKCA 0.4605
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.4618
Salivary secretion_Homo sapiens_hsa04970 PRKCA 0.4631
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 PIK3CA, PIK3CB 0.9547
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4631
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 PIK3CA, PIK3CB 0.9646
Insulin secretion_Homo sapiens_hsa04911 PRKCA 0.474
T cell receptor signaling pathway_Homo sapiens_hsa04660 PIK3CA, PIK3CB 0.9646
Peroxisome_Homo sapiens_hsa04146 XDH 0.479
Aldosterone synthesis and secretion_Homo sapiens_hsa04925 PRKCA 0.4831
Pancreatic secretion_Homo sapiens_hsa04972 CA2, PRKCA 1.0109
Complement and coagulation cascades_Homo sapiens_hsa04610 F3 0.4895
Adipocytokine signaling pathway_Homo sapiens_hsa04920 JAK2 0.5283
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3, KIT 1.0735
GABAergic synapse_Homo sapiens_hsa04727 SRC, PRKCA 1.0735
Thyroid hormone synthesis_Homo sapiens_hsa04918 PRKCA 0.5258
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.5308
Long-term potentiation_Homo sapiens_hsa04720 PRKCA 0.5415
Amphetamine addiction_Homo sapiens_hsa05031 PRKCA 0.5388
Shigellosis_Homo sapiens_hsa05131 SRC 0.5444
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.5444
B cell receptor signaling pathway_Homo sapiens_hsa04662 PIK3CA, PIK3CB 1.2033
Leishmaniasis_Homo sapiens_hsa05140 PTGS2, JAK2 1.2033
Gastric acid secretion_Homo sapiens_hsa04971 CA2, PRKCA 1.1965
Inositol phosphate metabolism_Homo sapiens_hsa00562 PIK3CA, PIK3CB 1.2172
Bile secretion_Homo sapiens_hsa04976 ABCB1, CA2 1.2172
PPAR signaling pathway_Homo sapiens_hsa03320 FABP4, MMP1 1.2311
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2, AOX1 1.2311
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.2311
Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 PRKCA 0.6021
Long-term depression_Homo sapiens_hsa04730 PRKCA, IGF1R 1.3222
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.6282
Vibrio cholerae infection_Homo sapiens_hsa05110 PRKCA 0.6282
Malaria_Homo sapiens_hsa05144 MET 0.6377
Endometrial cancer_Homo sapiens_hsa05213 PIK3CA, PIK3CB 1.4159
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.6398
Sphingolipid metabolism_Homo sapiens_hsa00600 GBA2 0.6449
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.6501
ABC transporters_Homo sapiens_hsa02010 ABCB1 0.6613
Cysteine and methionine metabolism_Homo sapiens_hsa00270 DNMT1 0.6556
Type II diabetes mellitus_Homo sapiens_hsa04930 PIK3CA, PIK3CB 1.4675
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 PRKCA, ESR1 1.48
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 PIK3CA, PIK3CB 1.5063
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.6927
African trypanosomiasis_Homo sapiens_hsa05143 PRKCA 0.743
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.7542
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7804
Base excision repair_Homo sapiens_hsa03410 APEX1 0.7602
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2 1.7647
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.7284
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.7991
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, TYR 1.6853
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.83
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.6668
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.7889
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8182
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.9504
Steroid biosynthesis_Homo sapiens_hsa00100 EBP 0.9278
Other glycan degradation_Homo sapiens_hsa00511 GBA2 0.9646
Folate biosynthesis_Homo sapiens_hsa00790 ALPL, ALPI 2.2911
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.3551
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.1322


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)