Component: Radix cudraniae 穿破石


Description of the Component

Component ID
 TCMH290
Latin Name
 Radix cudraniae
English Name
 root of tricuspid cudrania
Chinese Pinyin Name
 Chuan Po Shi
中文名
 穿破石
TCM Properties
 Cool,Slightly Bitter,Neutral
TCM Meridians
 Liver,Heart
Therapeutic Class English
Therapeutic Class Chinese
Functions
Toxicity
 NA
Geo-authentic habitats (道地产区)
 NA
Reference
 Chinese Pharmacopoeia (2015)
Barcode ID
Barcode Source

TCM Prescriptions with the Component

Prescription ID Prescription English Name Prescription Chinese Name
TCMFx3828 Bo Gu Decoction 驳骨水
TCMFx1774 Five Stone Decoction
TCMFx37 Gong Yan Ping Di Pills 宫炎平滴丸
TCMFx3295 Gong Yan Ping Tablets 宫炎平片
TCMFx7099 Huo Luo Zhi Tong Pills 活络止痛丸
TCMFx4155 Kang Lao Capsules 抗痨胶囊
TCMFx4147 Kang Lao Infusion 抗痨冲剂
TCMFx4160 Kang Lao Pills 抗痨丸
TCMFx5724 Xi Chuan Pills 息喘丸
TCMFx7131 Zhi Shang Ruan Ointment 治伤软膏
TCMFx328 Zhong Hua Die Da Pills 中华跌打丸
TCMFx6238 Zhong Hua Die Da Pills 中华跌打丸
TCMFx6231 Zhong Hua Die Da Wine 中华跌打酒

Targeted Human Proteins by the Ingredient of Component

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT1 EHMT2 Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 Transferase Q96KQ7
TCMT11 HIF1A Hypoxia-inducible factor 1 alpha Transcription factor Q16665
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT17 POLB DNA polymerase beta Transferase P06746
TCMT18 GAA Lysosomal alpha-glucosidase Hydrolase P10253
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT207 BACE1 Beta-secretase 1 Protease P56817
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT276 SLCO2B1 Solute carrier organic anion transporter family member 2B1 Transporter O94956
TCMT277 SLCO1B3 Solute carrier organic anion transporter family member 1B3 Transporter Q9NPD5
TCMT278 SLCO1B1 Solute carrier organic anion transporter family member 1B1 Transporter Q9Y6L6
TCMT283 PTPRS Receptor-type tyrosine-protein phosphatase S Hydrolase Q13332
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT31 CYP2C19 Cytochrome P450 2C19 Oxidoreductase P33261
TCMT327 TRPV1 Vanilloid receptor Ion channel Q8NER1
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT34 CYP2D6 Cytochrome P450 2D6 Oxidoreductase P10635
TCMT42 KMT2A Histone-lysine N-methyltransferase MLL Transferase Q03164
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT508 SYK Tyrosine-protein kinase SYK Kinase P43405
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT6 NFKB1 Nuclear factor NF-kappa-B p105 subunit Transcription factor P19838
TCMT61 MCL1 Induced myeloid leukemia cell differentiation protein Mcl-1 Unclassified Q07820
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT64 PPARD Peroxisome proliferator-activated receptor delta Nuclear receptor Q03181
TCMT67 PPARG Peroxisome proliferator-activated receptor gamma Nuclear receptor P37231
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT807 SLC22A12 Solute carrier family 22 member 12 Transporter Q96S37
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712


Targeted Pathogenic Microbes by the Ingredient of Component

Target ID Target Name
TCMT1092 Fatty acid synthase
TCMT1093 Enoyl-acyl-carrier protein reductase
TCMT1094 3-oxoacyl-acyl-carrier protein reductase
TCMT1218 Staphylococcus aureus
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1442 Leishmania donovani

Ingredient Structrues

Ingredient ID: TCMC921
Formula: C14H12O3

Ingredient ID: TCMC1830
Formula: C16H32O2

Ingredient ID: TCMC1777
Formula: C8H18O

Ingredient ID: TCMC1739
Formula: C12H20O2

Ingredient ID: TCMC1597
Formula: C15H10O7

Ingredient ID: TCMC1493
Formula: C10H18O

Properties

Ingredient ID Formulae Name MW AlogP MlogP XlogP # HBA # HBD PSA # Rotatable Bond # Ring # Heacy Atom Lipinski RO5 Violation
TCMC921 C14H12O3 Cis-Resveratrol 228.08 -0.9131 2.67 3.436 0 3 60.69 5 2 17 0
TCMC1493 C10H18O Linalool (+) 154.14 2.4692 2.45 2.468 1 1 20.23 8 0 11 0
TCMC1597 C15H10O7 Morin 302.04 -2.8012 2.34 0.952 2 5 127.45 6 3 22 0
TCMC1739 C12H20O2 Neryl Acetate 196.15 2.7188 2.56 3.264 2 0 26.3 10 0 14 0
TCMC1777 C8H18O Octanol 130.14 -2.1254 2.23 3.127 1 1 20.23 8 0 9 0
TCMC1830 C16H32O2 Palmitic Acid 256.24 -3.8977 3 7.57 2 1 37.3 16 0 18 2

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1. General Information of the Component  
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3. Putative Targets  
4. Activity & References for Filtering Putative Targets  
5. Ingredient Data & Chemical Structure Information (Properties, InChI, InChIkey, SMILES, etc.)