Component: Spina gleditsiae 皂角刺

Description of the Component

Component ID
Latin Name
Spina gleditsiae
English Name
spine of chinese honeylocust
Chinese Pinyin Name
Zao Jiao Ci
TCM Properties
TCM Meridians
Lung,Large Intestine
Therapeutic Class English
Blood activation and stasis removal
Therapeutic Class Chinese
cause subsidence of swelling, draw out of pus, and kill parasites
Geo-authentic habitats (道地产区)
Chinese Pharmacopoeia (2015)
Barcode ID
Barcode Source

TCM Prescriptions with the Component

Prescription ID Prescription English Name Prescription Chinese Name
TCMF2970 Ba Xian You 八仙油
TCMFx3251 Chi Tong Ning 齿痛宁
TCMF3355 Die Da Feng Shi Yao Wine 跌打风湿药酒
TCMFx2481 Fairy Decoction for Treating Cutaneous Infections 仙方活命饮
TCMF4469 Kou Qiang Yan Spray 口腔炎喷雾剂
TCMFx4862 Luo Fu Shan Bai Cao You 罗浮山百草油
TCMFx4511 Pi Fu Bing Xue Du Pills 皮肤病血毒丸
TCMFx1818 Powder for Promoting Pus Discharge 透脓散
TCMF845 Qian Lie Xin Capsule 前列欣胶囊
TCMFx653 Ru Kuai Xiao Capsule 乳块消胶囊
TCMFx5679 Ru Kuai Xiao Tablets 乳块消片
TCMFx1278 Rukuaixiao Tablets 乳块消片
TCMFx1855 Rukuaixiao Tablets 乳块消片
TCMF7434 Tuo Li Xiao Du Decoction 托里消毒饮
TCMF554 Wang Bi Granules 尪痹颗粒
TCMF553 Wang Bi Tablet 尪痹片
TCMFx5907 Xian Fang Huo Ming Tablets 仙方活命片
TCMF383 Xin Tong Oral Liquid 心通口服液
TCMF691 Yu Jin Yin Xie Tablet 郁金银屑片
TCMF6465 Yu Jin Yin Xie Tablets 郁金银屑片
TCMF6302 Zhong Sheng Pills 众生丸
TCMF7154 Zhong Sheng Tablets 众生片

Targeted Human Proteins by the Ingredient of Component

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT1 EHMT2 Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 Transferase Q96KQ7
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT143 CA3 Carbonic anhydrase III Lyase P07451
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT166 AKR1C2 Aldo-keto reductase family 1 member C2 Oxidoreductase P52895
TCMT167 AKR1C3 Aldo-keto-reductase family 1 member C3 Oxidoreductase P42330
TCMT168 AKR1C4 Aldo-keto reductase family 1 member C4 Oxidoreductase P17516
TCMT17 POLB DNA polymerase beta Transferase P06746
TCMT18 GAA Lysosomal alpha-glucosidase Hydrolase P10253
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT6 NFKB1 Nuclear factor NF-kappa-B p105 subunit Transcription factor P19838
TCMT69 THRB Thyroid hormone receptor beta-1 Nuclear receptor P10828
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT80 MAPK1 MAP kinase ERK2 Kinase P28482
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT95 MPG DNA-3-methyladenine glycosylase Hydrolase P29372

Targeted Pathogenic Microbes by the Ingredient of Component

Target ID Target Name
TCMT1108 Integrase
TCMT1218 Staphylococcus aureus
TCMT1251 Candida albicans

Ingredient Structrues

Ingredient ID: TCMC916
Formula: C9H8O2

Ingredient ID: TCMC898
Formula: C17H20O9

Ingredient ID: TCMC847
Formula: C9H8O4

Ingredient ID: TCMC6765
Formula: C20H22O7

Ingredient ID: TCMC6286
Formula: C15H14O5

Ingredient ID: TCMC5715
Formula: C15H12O6

Ingredient ID: TCMC4347
Formula: C15H10O5

Ingredient ID: TCMC4296
Formula: C11H12O4

Ingredient ID: TCMC4293
Formula: C16H16O4

Ingredient ID: TCMC4263
Formula: C15H12O5

Ingredient ID: TCMC3778
Formula: C8H9NO3

Ingredient ID: TCMC3231
Formula: C10H12O5

Ingredient ID: TCMC3031
Formula: C7H7NO

Ingredient ID: TCMC2863
Formula: C15H12O4

Ingredient ID: TCMC2845
Formula: C15H12O6


Ingredient ID Formulae Name MW AlogP MlogP XlogP # HBA # HBD PSA # Rotatable Bond # Ring # Heacy Atom Lipinski RO5 Violation
TCMC847 C9H8O4 Caffeic Acid 180.04 -0.7993 2.01 1.141 2 3 77.76 5 1 13 0
TCMC898 C17H20O9 Chlorogenic Acid Methyl Ester 368.11 -1.9452 2.34 -0.126 7 5 153.75 12 2 26 0
TCMC916 C9H8O2 Cinnamic Acid 148.05 0.1213 2.23 3.904 2 1 37.3 3 1 11 0
TCMC2845 C15H12O6 Hydrogenase 288.0633881 -2.4666 2.45 0.562 2 4 107.22 1 3 21 0
TCMC2863 C15H12O4 Licorice 256.0735589 -1.3541 2.67 1.86 1 2 66.76 1 3 19 0
TCMC3031 C7H7NO 4-Aminobenzaldehyde 121.0527638 -0.9423 2.01 1.417 2 1 43.09 1 1 9 0
TCMC3231 C10H12O5 Methyl Syringate 212.0684735 -0.5527 2.01 0.503 2 1 64.99 4 1 15 0
TCMC3778 C8H9NO3 4-Hydroxy-3-Methoxybenzamide 167.0582431 -1.1469 1.9 -0.102 2 2 72.55 2 1 12 0
TCMC4263 C15H12O5 Garbanzol 272.0684735 -2.0063 2.56 1.525 2 3 86.99 1 3 20 0
TCMC4293 C16H16O4 ((E)-3, 3′-Dimethoxy-4, 4′-Dihydroxystilbene) 272.104859 -0.5564 2.78 3.3 0 2 58.92 4 2 20 0
TCMC4296 C11H12O4 Sinapic Aldehyde 208.0735589 -0.3952 2.23 0.868 1 1 55.76 4 1 15 0
TCMC4347 C15H10O5 7,4’-Dihydroxyflavonol 270.0528234 -1.6882 2.56 2.264 4 3 77.76 1 3 20 0
TCMC5715 C15H12O6 5,7,3',5'-tetrahydroxy-flavanone 288.0633881 -2.2747 2.45 -0.066 1 4 107.22 1 3 21 0
TCMC6286 C15H14O5 4,4’-Dihydroxy-3,3’-Dimethoxybenzophenone 274.0841235 -1.288 2.56 1.597 1 2 75.99 4 2 20 0
TCMC6765 C20H22O7 Erythro-And Threo-Guaiacylglycerol-Β-Coniferyl Aldehyde Ether 374.136553 -1.5591 2.89 1.355 3 3 105.45 9 2 27 0

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1. General Information of the Component  
2. TCM Prescriptions with the Component  
3. Putative Targets  
4. Activity & References for Filtering Putative Targets  
5. Ingredient Data & Chemical Structure Information (Properties, InChI, InChIkey, SMILES, etc.)