| GO Term |
GO Name |
Enriched Genes |
Log10 Adjusted P-value |
|
[BP] GO:0065008 |
regulation of biological quality
|
ABCB1, ACHE, ADORA1, ADRB1, AKR1B1, ALOX12, ALOX15, APEX1, APP, AR, AURKB, AXL, BCL2, CA12, CA2, CA7, CACNA1C, CDK6, CHRM1, CHRM3, CHRNA3, CHRNA7, CNR1, CNR2, CYP19A1, CYP1A1, CYP1B1, EDNRA, EGFR, ESR1, F3, FABP3, FABP4, FLT3, GAA, GBA, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HCAR2, HIF1A, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, INSR, KDR, KIT, MET, PIK3CA, PIK3CB, POLA1, POLB, PPARA, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PTGS1, PTGS2, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TRPV1, XDH |
21.9362 |
|
[BP] GO:0010033 |
response to organic substance
|
AKR1B1, ALOX15, ALPL, APEX1, APP, AR, AXL, BCL2, CA2, CA9, CDK6, CHRNA3, CHRNA7, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, EGFR, ERBB2, ESR1, ESRRA, FABP3, FABP4, FLT3, GBA, GRIK5, GRM5, HIF1A, HSD11B2, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, KIT, MMP2, NR3C1, PIK3CA, POLB, PPARA, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, RORC, SMAD3, SRC, TEK, TRPV1, TYR |
17.9884 |
|
[BP] GO:1901700 |
response to oxygen-containing compound
|
AKR1B1, ALPL, APEX1, APP, AR, AXL, BCL2, CA9, CDK6, CHRNA3, CHRNA7, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, EGFR, ESR1, ESRRA, FABP3, GBA, GRIK5, GRM5, HSD11B2, HSD17B2, HSP90AB1, IGF1R, INSR, MMP2, MMP9, NR3C1, PIK3CA, POLB, PPARA, PPARG, PRKCB, PRKCD, PRKCE, PTGS2, RORC, SRC, TEK, TRPV1, TYR |
16.6428 |
|
[BP] GO:0042221 |
response to chemical
|
ABCB1, AKR1B1, ALOX15, ALPL, APEX1, APP, AR, AXL, BCL2, CA2, CA9, CDK6, CHRNA3, CHRNA7, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, EGFR, ERBB2, ESR1, ESRRA, FABP3, FABP4, FLT3, GBA, GRIK5, GRM5, HIF1A, HSD11B2, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, KIT, MMP2, MMP9, NR3C1, PIK3CA, POLB, PPARA, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, RORC, SMAD3, SRC, TEK, TERT, TRPV1, TYR |
15.8225 |
|
[BP] GO:0006629 |
lipid metabolic process
|
ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APP, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, EGFR, ERBB2, ESR1, FABP3, FABP4, FUCA1, FUT7, GBA, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, KIT, MET, PIK3CA, PIK3CB, PPARA, PPARG, PTGS1, PTGS2, TBXAS1, TRPV1 |
12.9436 |
|
[BP] GO:0010647 |
positive regulation of cell communication
|
ADORA1, ADRB1, AKR1B1, ALOX15, APP, AR, AXL, BCL2, CA2, CA7, CHRNA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, ERBB2, F3, FLT3, GBA, GPR35, GRM1, HCAR2, HIF1A, HSP90AB1, HSPA1A, INSR, KDR, KIT, MET, MMP12, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH |
12.7977 |
|
[BP] GO:0042592 |
homeostatic process
|
ADORA1, ADRB1, AKR1B1, ALOX12, APEX1, APP, AXL, BCL2, CA12, CA2, CA7, CACNA1C, CHRNA7, CNR1, EDNRA, EGFR, ESR1, FABP3, FABP4, FLT3, GAA, GBA, GPR35, GRIK5, GRM1, GRM5, HIF1A, HSP90AA1, HSP90AB1, INSR, MET, PIK3CA, PIK3CB, POLA1, POLB, PPARG, PRKCB, PRKCE, SMAD3, SRC, TERT, TRPV1 |
12.7977 |
|
[BP] GO:0023056 |
positive regulation of signaling
|
ADORA1, ADRB1, AKR1B1, ALOX15, APP, AR, AXL, BCL2, CA2, CA7, CHRNA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, ERBB2, F3, FLT3, GBA, GPR35, GRM1, HCAR2, HIF1A, HSP90AB1, HSPA1A, INSR, KDR, KIT, MET, MMP12, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH |
12.7764 |
|
[BP] GO:0009719 |
response to endogenous stimulus
|
AKR1B1, ALPL, APEX1, APP, AR, BCL2, CA2, CA9, CHRNA3, CHRNA7, CSNK2A1, CYP1A2, DNMT1, EGFR, ERBB2, ESR1, ESRRA, FABP3, FLT3, GBA, GRM5, HSD11B2, IGF1R, INSR, KIT, MMP2, NR3C1, PPARA, PPARG, PRKCD, PRKCE, PTGS2, SMAD3, SRC, TEK, TRPV1 |
12.7003 |
|
[BP] GO:0010941 |
regulation of cell death
|
ADORA1, AKR1B1, ALOX12, APEX1, AR, AURKB, AXL, BCL2, CHRNA7, CNR1, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GBA, GLO1, GRIK5, HCAR2, HIF1A, HSP90AB1, HSPA1A, IGF1R, KDR, KIT, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PPARG, PRKCA, PRKCD, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, XDH |
12.3346 |
|
[BP] GO:0010646 |
regulation of cell communication
|
ACHE, ADORA1, ADRB1, AKR1B1, ALOX15, APP, AR, AURKB, AXL, BACE1, BCL2, CA2, CA7, CACNA1C, CHRNA3, CHRNA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, DYRK1A, EGFR, ERBB2, ESR1, ESR2, F3, FLT3, GBA, GPR35, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HIF1A, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH |
11.7766 |
|
[BP] GO:0048522 |
positive regulation of cellular process
|
ACHE, ADORA1, ADRB1, AKR1B1, ALOX12, ALOX15, APEX1, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CHRM1, CHRNA3, CHRNA7, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DNMT1, DUSP3, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, GBA, GPR35, GRIK5, GRM1, GRM5, HCAR2, HIF1A, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH |
11.7766 |
|
[BP] GO:0009725 |
response to hormone
|
AKR1B1, ALPL, APEX1, AR, BCL2, CA2, CA9, CHRNA3, CHRNA7, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, GBA, HSD11B2, INSR, KIT, NR3C1, PPARA, PPARG, PRKCD, PRKCE, PTGS2, SRC, TEK, TRPV1 |
11.7766 |
|
[BP] GO:0070887 |
cellular response to chemical stimulus
|
AKR1B1, ALOX15, ALPL, APEX1, APP, AR, AXL, BCL2, CDK6, CYP1A1, CYP1A2, CYP1B1, DNMT1, EGFR, ERBB2, ESR1, FABP4, FLT3, GBA, GRIK5, GRM5, HIF1A, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, KIT, MMP2, MMP9, NR3C1, PIK3CA, PPARG, PRKCB, PRKCD, PRKCE, PTGS2, RORC, SMAD3, SRC, TERT, TRPV1 |
11.7534 |
|
[BP] GO:0019369 |
arachidonic acid metabolic process
|
ALOX12, ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGS1, PTGS2, TBXAS1 |
11.6772 |
|
[BP] GO:0071310 |
cellular response to organic substance
|
AKR1B1, ALOX15, ALPL, APEX1, APP, AR, AXL, BCL2, CDK6, CYP1A1, CYP1B1, DNMT1, EGFR, ERBB2, ESR1, FABP4, FLT3, GBA, GRIK5, GRM5, HIF1A, HSP90AB1, IGF1R, INSR, KDR, KIT, MMP2, NR3C1, PIK3CA, PPARG, PRKCB, PRKCD, PRKCE, PTGS2, RORC, SMAD3, SRC, TRPV1 |
11.649 |
|
[BP] GO:0023051 |
regulation of signaling
|
ACHE, ADORA1, ADRB1, AKR1B1, ALOX15, APP, AR, AURKB, AXL, BACE1, BCL2, CA2, CA7, CACNA1C, CHRNA3, CHRNA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, DYRK1A, EGFR, ERBB2, ESR1, ESR2, F3, FLT3, GBA, GPR35, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HIF1A, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH |
11.6215 |
|
[BP] GO:0043067 |
regulation of programmed cell death
|
ADORA1, AKR1B1, ALOX12, APEX1, AR, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GLO1, GRIK5, HCAR2, HIF1A, HSP90AB1, HSPA1A, IGF1R, KDR, KIT, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARG, PRKCA, PRKCD, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, XDH |
11.4687 |
|
[BP] GO:0048518 |
positive regulation of biological process
|
ABCB1, ACHE, ADORA1, ADRB1, AKR1B1, ALOX12, ALOX15, APEX1, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CHRM1, CHRM3, CHRNA3, CHRNA7, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DNMT1, DUSP3, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GBA, GPR35, GRIK5, GRM1, GRM5, HCAR2, HIF1A, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SLC1A1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH |
11.0768 |
|
[BP] GO:0009967 |
positive regulation of signal transduction
|
ADORA1, ADRB1, AKR1B1, ALOX15, APP, AR, AXL, BCL2, CHRNA7, CSNK2A1, CYP1B1, EGFR, ERBB2, F3, FLT3, GPR35, GRM1, HIF1A, HSP90AB1, HSPA1A, INSR, KDR, KIT, MET, MMP12, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH |
10.8586 |
|
[BP] GO:0014070 |
response to organic cyclic compound
|
ALPL, APEX1, APP, AR, BCL2, CA2, CA9, CNR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FLT3, GBA, HSD11B2, HSP90AB1, NR3C1, PPARG, PRKCE, PRKCG, PTGS2, RORC, SRC, TEK, TRPV1, TYR |
10.8515 |
|
[BP] GO:0051173 |
positive regulation of nitrogen compound metabolic process
|
ADORA1, ADRB1, ALOX15, APP, AR, AURKB, BCL2, CDC25B, CHRNA3, CHRNA7, CSNK2A1, DNMT1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GBA, GRM1, GRM5, HIF1A, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, NR3C1, PGR, PIK3CA, PIK3CB, PPARA, PPARG, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH |
10.4996 |
|
[BP] GO:0042127 |
regulation of cell proliferation
|
ADORA1, ADORA3, AKR1B1, ALOX12, APP, AR, BCL2, CDC25B, CDK6, CHRM1, CHRNA7, CSNK2A1, CYP1B1, DNMT1, EGFR, ERBB2, ESR1, ESRRA, F3, FABP3, FLT3, HIF1A, HSPA1A, IGF1R, INSR, KDR, KIT, MMP12, MMP2, MMP9, NUAK1, PGR, PIM1, PPARG, PRKCA, PTGS1, PTGS2, SMAD3, SRC, TEK, TERT, XDH |
10.4996 |
|
[BP] GO:0044281 |
small molecule metabolic process
|
AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DAO, FABP3, FUCA1, FUT7, GAA, GBA, GBA2, GLO1, HIF1A, HSPA1A, PIK3CA, PIM1, PPARA, PPARG, PTGS1, PTGS2, TBXAS1, TYR, XDH |
10.485 |
|
[BP] GO:0019220 |
regulation of phosphate metabolic process
|
ADORA1, ADRB1, ALOX15, APP, AR, BCL2, CDC25B, CHRM5, CHRNA3, CHRNA7, DUSP3, EDNRA, EGFR, ERBB2, ESRRB, FABP3, FABP4, FLT3, GBA, GRM1, GRM3, GRM5, GRM8, HIF1A, HSP90AB1, IGF1R, INSR, KDR, KIT, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH |
10.3163 |
|
[BP] GO:0042981 |
regulation of apoptotic process
|
ADORA1, AKR1B1, ALOX12, APEX1, AR, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GLO1, GRIK5, HCAR2, HIF1A, HSP90AB1, HSPA1A, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PIM1, PPARG, PRKCA, PRKCD, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, XDH |
10.3163 |
|
[BP] GO:0051174 |
regulation of phosphorus metabolic process
|
ADORA1, ADRB1, ALOX15, APP, AR, BCL2, CDC25B, CHRM5, CHRNA3, CHRNA7, DUSP3, EDNRA, EGFR, ERBB2, ESRRB, FABP3, FABP4, FLT3, GBA, GRM1, GRM3, GRM5, GRM8, HIF1A, HSP90AB1, IGF1R, INSR, KDR, KIT, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH |
10.2074 |
|
[BP] GO:0010562 |
positive regulation of phosphorus metabolic process
|
ADORA1, ADRB1, ALOX15, APP, AR, BCL2, CDC25B, CHRNA3, CHRNA7, EGFR, ERBB2, ESRRB, FABP3, FLT3, GBA, GRM1, GRM5, HIF1A, HSP90AB1, INSR, KDR, KIT, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH |
10.0908 |
|
[BP] GO:0045937 |
positive regulation of phosphate metabolic process
|
ADORA1, ADRB1, ALOX15, APP, AR, BCL2, CDC25B, CHRNA3, CHRNA7, EGFR, ERBB2, ESRRB, FABP3, FLT3, GBA, GRM1, GRM5, HIF1A, HSP90AB1, INSR, KDR, KIT, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH |
10.0908 |
|
[BP] GO:0033559 |
unsaturated fatty acid metabolic process
|
ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGS1, PTGS2, TBXAS1 |
10.0908 |
|
[BP] GO:0032879 |
regulation of localization
|
ABCB1, ACHE, ADORA1, ADORA3, ALOX12, ALOX15, APEX1, APP, AR, AXL, BCL2, CA2, CA7, CACNA1C, CDK6, CHRM1, CHRNA3, CNR1, CSNK2A1, CYP19A1, CYP1B1, EGFR, ERBB2, F3, GPR35, GRIK5, GRM5, HCAR2, HIF1A, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, PIK3CB, PPARA, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TRPV1 |
10.0908 |
|
[BP] GO:0042493 |
response to drug
|
ABCB1, AKR1B1, APEX1, AXL, BCL2, CA9, CDK6, CHRNA3, CHRNA7, CNR1, CNR2, CYP1A1, CYP1B1, EGFR, FABP3, GBA, HSD11B2, HSP90AB1, KDR, NR3C1, POLB, PPARG, PRKCD, PRKCE, PRKCG, PTGS2, SRC, TRPV1 |
9.99644 |
|
[BP] GO:0031325 |
positive regulation of cellular metabolic process
|
ADORA1, ADRB1, ALOX15, APP, AR, AURKB, BCL2, CDC25B, CHRNA3, CHRNA7, DNMT1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, GBA, GRM1, GRM5, HIF1A, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, NR3C1, PGR, PIK3CA, PIK3CB, PPARA, PPARG, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH |
9.91963 |
|
[BP] GO:0008152 |
metabolic process
|
ACHE, ADORA1, ADRB1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AR, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DAO, DNMT1, DUSP3, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUCA1, FUT7, GAA, GBA, GBA2, GLO1, HIF1A, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MGAM, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NR3C2, NUAK1, PGR, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SLC22A2, SMAD3, SRC, TBXAS1, TEK, TERT, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH |
9.86935 |
|
[BP] GO:0007165 |
signal transduction
|
ADORA1, ADORA3, ADRB1, AKR1B1, APP, AR, AXL, BCL2, CA1, CA2, CACNA1C, CDK6, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA3, CHRNA7, CNR1, CNR2, CSNK2A1, CYP1B1, DNMT1, EDNRA, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HIF1A, HSP90AA1, HSP90AB1, IGF1R, INSR, KDR, KIT, MET, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIK3CA, PIK3CB, PIM1, POLB, PPARA, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TRPV1 |
9.83572 |
|
[BP] GO:0050804 |
modulation of chemical synaptic transmission
|
ACHE, ADORA1, APP, BACE1, CA2, CA7, CHRNA3, CHRNA7, CNR1, CNR2, EGFR, GRIK5, GRM1, GRM3, GRM5, GRM8, KIT, PRKCE, PTGS2 |
9.80546 |
|
[BP] GO:0099177 |
regulation of trans-synaptic signaling
|
ACHE, ADORA1, APP, BACE1, CA2, CA7, CHRNA3, CHRNA7, CNR1, CNR2, EGFR, GRIK5, GRM1, GRM3, GRM5, GRM8, KIT, PRKCE, PTGS2 |
9.80546 |
|
[BP] GO:0009628 |
response to abiotic stimulus
|
ADORA1, ADRB1, AKR1B1, APP, AURKB, BCL2, CA2, CHRNA7, CYP1A1, EDNRA, EGFR, GBA, GRM1, HIF1A, HSD11B2, HSP90AA1, HSP90AB1, HSPA1A, KIT, MMP2, POLB, PPARA, PPARG, PRKCB, PRKCE, PTGS2, SMAD3, SRC, TEK, TERT, TRPV1, TYR |
9.80334 |
|
[BP] GO:0006690 |
icosanoid metabolic process
|
ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGS1, PTGS2, TBXAS1 |
9.78583 |
|
[BP] GO:0015701 |
bicarbonate transport
|
CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 |
9.77336 |
|
[BP] GO:0050896 |
response to stimulus
|
ABCB1, ACHE, ADORA1, ADORA3, ADRB1, AKR1B1, ALOX15, ALPL, APEX1, APP, AR, AURKB, AXL, BCL2, CA2, CA6, CA9, CDK6, CHRM2, CHRNA3, CHRNA7, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, EDNRA, EGFR, ERBB2, ESR1, ESRRA, F3, FABP3, FABP4, FLT3, GBA, GRIK5, GRM1, GRM5, HIF1A, HSD11B2, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, KIT, MMP12, MMP2, MMP9, NR3C1, NUAK1, PIK3CA, PIK3CB, POLA1, POLB, PPARA, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, TYR |
9.68943 |
|
[BP] GO:0060548 |
negative regulation of cell death
|
ADORA1, AKR1B1, ALOX12, AR, AURKB, AXL, BCL2, CSNK2A1, EGFR, GBA, GLO1, HIF1A, HSP90AB1, HSPA1A, IGF1R, KDR, KIT, MET, MMP9, PIK3CA, PIM1, PPARA, PRKCA, PRKCD, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT |
9.67663 |
|
[BP] GO:0048584 |
positive regulation of response to stimulus
|
ADORA1, ADRB1, AKR1B1, ALOX15, APP, AR, AXL, BCL2, CHRNA7, CNR1, CSNK2A1, CYP1B1, EGFR, ERBB2, ESRRA, F3, FABP4, FLT3, GPR35, GRM1, HIF1A, HSP90AA1, HSP90AB1, HSPA1A, INSR, KDR, KIT, MET, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH |
9.66252 |
|
[BP] GO:0033993 |
response to lipid
|
ALPL, AR, AXL, BCL2, CA2, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, GBA, HSD11B2, HSD17B2, NR3C1, PPARG, PRKCE, PTGS2, RORC, SRC, TYR |
9.49957 |
|
[BP] GO:0050790 |
regulation of catalytic activity
|
ADORA1, ADORA3, ADRB1, APP, AR, AURKB, BCL2, CDC25B, CHRNA3, CHRNA7, CNR1, CNR2, CSNK2A1, DUSP3, EDNRA, EGFR, ERBB2, ESR1, F3, FABP4, FLT3, GBA, GRM1, GRM3, GRM5, HIF1A, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KIT, MMP9, NUAK1, PIK3CA, PIK3CB, PPARG, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, XDH |
9.43389 |
|
[BP] GO:1902533 |
positive regulation of intracellular signal transduction
|
ADORA1, ADRB1, AKR1B1, ALOX15, APP, AR, AXL, BCL2, CHRNA7, CYP1B1, EGFR, ERBB2, F3, FLT3, GPR35, GRM1, HSPA1A, INSR, KDR, KIT, MET, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCE, PTGS2, PTPN1, SRC, TEK, XDH |
9.41864 |
|
[BP] GO:0051239 |
regulation of multicellular organismal process
|
ADORA1, ADORA3, ADRB1, ALOX12, APP, AR, AXL, BCL2, CA2, CACNA1C, CDK6, CHRM1, CHRM2, CHRM3, CHRNA3, CHRNA7, CNR1, CYP1B1, EGFR, ERBB2, ESR1, ESRRA, ESRRB, F3, GAA, GBA, GPR35, GRM1, HCAR2, HIF1A, HSP90AB1, HSPA1A, INSR, KDR, KIT, MET, MMP12, MMP9, PIK3CA, PIM1, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, SLC1A1, SMAD3, SRC, TEK, TERT, TNKS2, TRPV1, XDH |
9.38774 |
|
[BP] GO:0032501 |
multicellular organismal process
|
ADORA1, ADRB1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, APP, AR, AXL, BCL2, CACNA1C, CHRM1, CHRM3, CHRM5, CHRNA3, CHRNA7, CNR1, CNR2, CYP19A1, CYP1A2, CYP1B1, DUSP3, EDNRA, EGFR, ESR1, ESRRB, F3, FABP4, GAA, GBA, GRM1, GRM5, GRM8, HIF1A, HSD11B2, HSD17B2, IGF1R, INSR, KIT, MET, MGAM, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIM1, PPARA, PRKCD, PRKCG, PTGS2, RORC, SMAD3, SRC, TEK, TNKS2, TRPV1, TYR |
9.38774 |
|
[BP] GO:1902531 |
regulation of intracellular signal transduction
|
ADORA1, ADRB1, AKR1B1, ALOX15, APP, AR, AURKB, AXL, BCL2, CHRNA7, CSNK2A1, CYP1B1, DUSP3, DYRK1A, EGFR, ERBB2, ESR1, F3, FLT3, GBA, GPR35, GRM1, HIF1A, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TEK, XDH |
9.21379 |
|
[BP] GO:0032502 |
developmental process
|
ACHE, ADORA1, ADRB1, AKR1B1, ALOX15, ALPL, APEX1, APP, AR, AURKB, AXL, BCL2, CA2, CA9, CACNA1C, CBR1, CDC25B, CDK6, CHRM1, CHRM2, CHRM3, CHRNA3, CHRNA7, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, DYRK1A, EDNRA, EGFR, ERBB2, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, GAA, GBA, GBA2, GLO1, HIF1A, HSD11B1, HSD17B2, HSP90AB1, INSR, KDR, KIT, MET, MMP2, MMP9, PGR, PIK3CA, PIK3CB, PIM1, POLB, PPARA, PPARG, PRKCA, PRKCD, PTGS2, RORC, SMAD3, SRC, TEK, TERT, TNKS2, TOP2A, TYR |
9.21379 |
|
[BP] GO:0009893 |
positive regulation of metabolic process
|
ADORA1, ADRB1, ALOX15, APP, AR, AURKB, BCL2, CDC25B, CHRNA3, CHRNA7, CSNK2A1, DNMT1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, GBA, GRM1, GRM5, HIF1A, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, NR3C1, PGR, PIK3CA, PIK3CB, PPARA, PPARG, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH |
9.20509 |
|
[BP] GO:0043069 |
negative regulation of programmed cell death
|
ADORA1, AKR1B1, ALOX12, AR, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HIF1A, HSP90AB1, HSPA1A, IGF1R, KDR, KIT, MET, MMP9, PIK3CA, PIM1, PRKCA, PRKCD, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT |
9.20253 |
|
[BP] GO:0019748 |
secondary metabolic process
|
AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, TYR |
9.17658 |
|
[BP] GO:0070482 |
response to oxygen levels
|
ADORA1, BCL2, CHRNA7, CYP1A1, EDNRA, HIF1A, HSD11B2, MMP2, POLB, PPARA, PPARG, PRKCB, PRKCE, PTGS2, SMAD3, SRC, TEK, TERT |
9.14483 |
|
[BP] GO:0006730 |
one-carbon metabolic process
|
CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 |
9.10383 |
|
[BP] GO:0051716 |
cellular response to stimulus
|
AKR1B1, ALOX15, ALPL, APEX1, APP, AR, AURKB, AXL, BCL2, CA2, CA9, CDK6, CYP1A1, CYP1A2, CYP1B1, DNMT1, EGFR, ERBB2, ESR1, FABP4, FLT3, GBA, GRIK5, GRM1, GRM5, HIF1A, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, KIT, MMP2, MMP9, NR3C1, NUAK1, PIK3CA, POLA1, POLB, PPARG, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, RORC, SMAD3, SRC, TERT, TOP2A, TRPV1 |
9.10383 |
|
[BP] GO:0048878 |
chemical homeostasis
|
AKR1B1, ALOX12, APP, BCL2, CA12, CA2, CA7, CACNA1C, CHRNA7, CNR1, EDNRA, EGFR, ESR1, FABP3, FABP4, GBA, GPR35, GRIK5, GRM1, GRM5, HIF1A, INSR, MET, PIK3CA, PIK3CB, PPARG, PRKCB, PRKCE, SMAD3, TRPV1 |
9.09752 |
|
[BP] GO:0080134 |
regulation of response to stress
|
ABCB1, ADORA1, ALOX12, APP, CDK6, CNR1, CNR2, CYP19A1, DUSP3, DYRK1A, EGFR, ESR1, F3, FABP4, GBA, HIF1A, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, MET, MMP12, MMP2, NUAK1, PPARA, PPARG, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH |
8.91724 |
|
[BP] GO:0044255 |
cellular lipid metabolic process
|
ACHE, AKR1B10, ALOX12, ALOX15, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, EGFR, ERBB2, FABP3, FABP4, FUCA1, FUT7, GBA, GBA2, KIT, MET, PIK3CA, PIK3CB, PPARA, PPARG, PTGS1, PTGS2, TBXAS1 |
8.88653 |
|
[BP] GO:0065009 |
regulation of molecular function
|
ABCB1, ADORA1, ADORA3, ADRB1, APP, AR, AURKB, BCL2, CDC25B, CHRNA3, CHRNA7, CNR1, CNR2, CSNK2A1, CYP1B1, CYP2D6, DUSP3, EDNRA, EGFR, ERBB2, ESR1, ESR2, F3, FABP4, FLT3, GBA, GPR35, GRM1, GRM3, GRM5, HIF1A, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KIT, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TRPV1, XDH |
8.88599 |
|
[BP] GO:0010604 |
positive regulation of macromolecule metabolic process
|
ADORA1, ALOX15, APP, AR, AURKB, BCL2, CDC25B, CHRNA3, CHRNA7, CSNK2A1, DNMT1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GBA, GRM1, GRM5, HIF1A, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, NR3C1, PGR, PIK3CA, PIK3CB, PPARA, PPARG, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH |
8.88119 |
|
[BP] GO:0001676 |
long-chain fatty acid metabolic process
|
ALOX12, ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGS1, PTGS2, TBXAS1 |
8.83118 |
|
[BP] GO:0044237 |
cellular metabolic process
|
ACHE, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AR, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DAO, DNMT1, DUSP3, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUCA1, FUT7, GAA, GBA, GBA2, GLO1, HIF1A, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MGAM, MMP1, MMP2, NQO2, NR3C1, NR3C2, NUAK1, PGR, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SLC22A2, SMAD3, SRC, TBXAS1, TEK, TERT, TNKS, TNKS2, TOP2A, TYR, XDH |
8.66575 |
|
[BP] GO:0042327 |
positive regulation of phosphorylation
|
ADORA1, ALOX15, APP, AR, BCL2, CDC25B, CHRNA3, CHRNA7, EGFR, ERBB2, ESRRB, FLT3, GRM1, GRM5, HIF1A, HSP90AB1, INSR, KDR, KIT, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TEK, XDH |
8.65735 |
|
[BP] GO:0044093 |
positive regulation of molecular function
|
ABCB1, ADORA1, ADRB1, APP, AR, AURKB, BCL2, CDC25B, CHRNA3, CHRNA7, EDNRA, EGFR, ERBB2, ESR1, ESR2, F3, FLT3, GRM1, GRM5, HIF1A, HSP90AA1, HSP90AB1, HSPA1A, INSR, KIT, MET, MMP9, PIK3CA, PIK3CB, PPARG, PRKCB, PRKCD, PRKCE, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, XDH |
8.62566 |
|
[BP] GO:1901701 |
cellular response to oxygen-containing compound
|
AKR1B1, APEX1, APP, AR, AXL, CDK6, CYP1B1, DNMT1, EGFR, ESR1, GRIK5, GRM5, IGF1R, INSR, MMP2, MMP9, NR3C1, PIK3CA, PPARG, PRKCB, PRKCD, PRKCE, PTGS2, RORC, SRC, TRPV1 |
8.40891 |
|
[BP] GO:1901698 |
response to nitrogen compound
|
AKR1B1, APEX1, APP, CHRNA3, CHRNA7, CNR1, CNR2, DNMT1, EGFR, FABP3, FLT3, GRM5, HSD11B2, HSP90AB1, IGF1R, INSR, MMP2, PPARA, PPARG, PRKCD, PRKCE, PRKCG, PTGS2, SRC, TEK, TRPV1, TYR |
8.35403 |
|
[BP] GO:2000145 |
regulation of cell motility
|
ADORA1, ADORA3, ALOX12, APEX1, APP, BCL2, CDK6, CYP19A1, CYP1B1, EGFR, ERBB2, F3, HIF1A, IGF1R, INSR, KDR, KIT, MET, MMP9, PPARG, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TEK, TERT |
8.3442 |
|
[BP] GO:0010243 |
response to organonitrogen compound
|
AKR1B1, APEX1, APP, CHRNA7, CNR1, CNR2, DNMT1, EGFR, FABP3, FLT3, GRM5, HSD11B2, HSP90AB1, IGF1R, INSR, MMP2, PPARA, PPARG, PRKCD, PRKCE, PRKCG, PTGS2, SRC, TEK, TRPV1, TYR |
8.3442 |
|
[BP] GO:0040012 |
regulation of locomotion
|
ADORA1, ADORA3, ALOX12, APEX1, APP, BCL2, CDK6, CHRM1, CYP19A1, CYP1B1, EGFR, ERBB2, F3, HIF1A, IGF1R, INSR, KDR, KIT, MET, MMP9, PPARG, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TEK, TERT |
8.31218 |
|
[BP] GO:0051270 |
regulation of cellular component movement
|
ADORA1, ADORA3, ALOX12, APEX1, APP, BCL2, CACNA1C, CDK6, CYP19A1, CYP1B1, EGFR, ERBB2, F3, HIF1A, IGF1R, INSR, KDR, KIT, MET, MMP9, PPARG, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TEK, TERT |
8.28724 |
|
[BP] GO:0055114 |
oxidation-reduction process
|
AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DAO, GAA, HSD11B1, HSD11B2, HSD17B1, HSD17B2, NQO2, PPARG, PTGS1, PTGS2, TBXAS1, TYR, XDH |
8.2691 |
|
[BP] GO:0048513 |
animal organ development
|
ACHE, AR, AXL, BCL2, CA2, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EDNRA, EGFR, ERBB2, ESR1, ESRRA, ESRRB, FLT3, HIF1A, HSD11B1, HSD17B2, HSP90AB1, INSR, KDR, KIT, PIK3CA, POLB, PPARA, PPARG, SMAD3, SRC, TEK, TYR |
8.13824 |
|
[BP] GO:0001666 |
response to hypoxia
|
ADORA1, BCL2, CHRNA7, CYP1A1, EDNRA, HIF1A, HSD11B2, MMP2, PPARA, PRKCB, PRKCE, PTGS2, SMAD3, SRC, TEK, TERT |
8.03499 |
|
[BP] GO:0048583 |
regulation of response to stimulus
|
ABCB1, ADORA1, ADRB1, AKR1B1, ALOX12, ALOX15, APP, AR, AURKB, AXL, BCL2, CDK6, CHRNA3, CHRNA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, F3, FABP4, FLT3, GBA, GPR35, GRM1, HIF1A, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH |
8.02363 |
|
[BP] GO:0043066 |
negative regulation of apoptotic process
|
ADORA1, AKR1B1, ALOX12, AR, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HIF1A, HSP90AB1, HSPA1A, IGF1R, KDR, MMP9, PIK3CA, PIM1, PRKCA, PRKCD, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT |
8.01393 |
|
[BP] GO:0018108 |
peptidyl-tyrosine phosphorylation
|
AXL, DYRK1A, EGFR, ERBB2, FLT3, HSP90AA1, IGF1R, INSR, KDR, KIT, MET, PRKCD, SRC, TEK |
7.94711 |
|
[BP] GO:0051049 |
regulation of transport
|
ABCB1, ACHE, ADORA1, ALOX15, APP, AXL, BCL2, CA2, CA7, CACNA1C, CHRM1, CHRNA3, CNR1, CYP19A1, EGFR, ERBB2, GPR35, GRIK5, GRM5, HCAR2, HIF1A, HSP90AB1, HSPA1A, INSR, MMP12, MMP9, PIK3CB, PPARA, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TERT, TRPV1 |
7.87588 |
|
[BP] GO:0036293 |
response to decreased oxygen levels
|
ADORA1, BCL2, CHRNA7, CYP1A1, EDNRA, HIF1A, HSD11B2, MMP2, PPARA, PRKCB, PRKCE, PTGS2, SMAD3, SRC, TEK, TERT |
7.87011 |
|
[BP] GO:0006468 |
protein phosphorylation
|
APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DYRK1A, EGFR, ERBB2, FLT3, HSP90AA1, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TNKS |
7.87011 |
|
[BP] GO:0018212 |
peptidyl-tyrosine modification
|
AXL, DYRK1A, EGFR, ERBB2, FLT3, HSP90AA1, IGF1R, INSR, KDR, KIT, MET, PRKCD, SRC, TEK |
7.87011 |
|
[BP] GO:0032270 |
positive regulation of cellular protein metabolic process
|
ADORA1, ALOX15, APP, AR, BCL2, CDC25B, CHRNA3, CHRNA7, DNMT1, DYRK1A, EGFR, ERBB2, ESR1, F3, FLT3, GBA, GRM1, GRM5, HSP90AB1, HSPA1A, INSR, KDR, KIT, MMP9, PIK3CA, PIK3CB, PPARG, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH |
7.85855 |
|
[BP] GO:1901568 |
fatty acid derivative metabolic process
|
ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGS1, PTGS2, TBXAS1 |
7.85855 |
|
[BP] GO:0051247 |
positive regulation of protein metabolic process
|
ADORA1, ALOX15, APP, AR, BCL2, CDC25B, CHRNA3, CHRNA7, CSNK2A1, DNMT1, DYRK1A, EGFR, ERBB2, ESR1, F3, FLT3, GBA, GRM1, GRM5, HSP90AB1, HSPA1A, INSR, KDR, KIT, MMP9, PIK3CA, PIK3CB, PPARG, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH |
7.80825 |
|
[BP] GO:0048523 |
negative regulation of cellular process
|
ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, APEX1, APP, AR, AURKB, AXL, BCL2, CDK6, CHRNA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DNMT1, DUSP3, DYRK1A, EDNRA, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GBA, GLO1, GPR35, GRM3, GRM8, HIF1A, HSP90AB1, HSPA1A, IGF1R, KDR, KIT, MET, MMP12, MMP9, NR3C1, PIK3CA, PIM1, PPARA, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH |
7.79775 |
|
[BP] GO:0010035 |
response to inorganic substance
|
AKR1B1, ALOX15, APEX1, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, HIF1A, KDR, KIT, MMP9, PRKCD, PTGS2, SRC, TERT |
7.78983 |
|
[BP] GO:0001934 |
positive regulation of protein phosphorylation
|
ADORA1, ALOX15, APP, AR, BCL2, CDC25B, CHRNA3, CHRNA7, EGFR, ERBB2, FLT3, GRM1, GRM5, HSP90AB1, INSR, KDR, KIT, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TEK, XDH |
7.78983 |
|
[BP] GO:0048519 |
negative regulation of biological process
|
ACHE, ADORA1, ADORA3, ADRB1, AKR1B1, ALOX12, ALOX15, APEX1, APP, AR, AURKB, AXL, BCL2, CDK6, CHRNA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DNMT1, DUSP3, DYRK1A, EDNRA, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GBA, GLO1, GPR35, GRM3, GRM8, HCAR2, HIF1A, HSP90AB1, HSPA1A, IGF1R, KDR, KIT, MET, MMP12, MMP9, NR3C1, PGR, PIK3CA, PIM1, PPARA, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH |
7.74349 |
|
[BP] GO:0008284 |
positive regulation of cell proliferation
|
AKR1B1, ALOX12, AR, BCL2, CDC25B, CDK6, CHRM1, CHRNA7, CSNK2A1, EGFR, ERBB2, ESR1, F3, FLT3, HIF1A, IGF1R, INSR, KDR, KIT, MMP12, MMP2, MMP9, PIM1, PRKCA, PTGS2, TEK, TERT |
7.73716 |
|
[BP] GO:0046777 |
protein autophosphorylation
|
AURKB, CSNK2A1, DYRK1A, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, KIT, PIM1, PRKCG, SRC, TEK |
7.69699 |
|
[BP] GO:0015711 |
organic anion transport
|
ABCB1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA, PPARG, SLC1A1, SLC22A1, SLC22A2, SLC22A3, TRPV1 |
7.67967 |
|
[BP] GO:0043401 |
steroid hormone mediated signaling pathway
|
AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, NR3C2, PGR, PPARA, PPARG, RORC, SRC |
7.6377 |
|
[BP] GO:0009892 |
negative regulation of metabolic process
|
ADORA1, APEX1, APP, AR, AURKB, BCL2, CHRNA7, CNR1, CNR2, CSNK2A1, CYP2D6, DNMT1, DUSP3, DYRK1A, EDNRA, EGFR, ESR1, ESR2, ESRRA, FABP4, GBA, GRM3, GRM8, HCAR2, HIF1A, HSP90AB1, HSPA1A, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PGR, PIK3CA, PPARA, PPARG, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TRPV1, XDH |
7.60546 |
|
[BP] GO:0030334 |
regulation of cell migration
|
ADORA1, ADORA3, ALOX12, APEX1, APP, BCL2, CYP19A1, CYP1B1, EGFR, F3, HIF1A, IGF1R, INSR, KDR, KIT, MET, MMP9, PPARG, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TEK, TERT |
7.55446 |
|
[BP] GO:0043085 |
positive regulation of catalytic activity
|
ADORA1, ADRB1, APP, AURKB, BCL2, CDC25B, CHRNA3, CHRNA7, EDNRA, EGFR, ERBB2, ESR1, F3, FLT3, GRM1, GRM5, HIF1A, HSP90AA1, HSP90AB1, HSPA1A, INSR, KIT, PIK3CA, PIK3CB, PPARG, PRKCD, PRKCE, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, XDH |
7.51477 |
|
[BP] GO:0042325 |
regulation of phosphorylation
|
ADORA1, ALOX15, APP, AR, BCL2, CDC25B, CHRNA3, CHRNA7, DUSP3, EGFR, ERBB2, ESRRB, FABP4, FLT3, GBA, GRM1, GRM5, HIF1A, HSP90AB1, IGF1R, INSR, KDR, KIT, MMP9, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TEK, XDH |
7.49427 |
|
[BP] GO:0008283 |
cell proliferation
|
ABCB1, ACHE, AR, AURKB, BCL2, CHRM1, CHRM3, CHRM5, CYP1A1, EDNRA, EGFR, ERBB2, ESR1, FLT3, KIT, MET, PIK3CB, PIM1, POLA1, PRKCD, SRC, TEK, TYR |
7.49427 |
|
[BP] GO:0008202 |
steroid metabolic process
|
AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, ESR1, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2 |
7.4205 |
|
[BP] GO:0031401 |
positive regulation of protein modification process
|
ADORA1, ALOX15, APP, AR, BCL2, CDC25B, CHRNA3, CHRNA7, DNMT1, DYRK1A, EGFR, ERBB2, FLT3, GBA, GRM1, GRM5, HSP90AB1, INSR, KDR, KIT, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TEK, XDH |
7.38645 |
|
[BP] GO:0031399 |
regulation of protein modification process
|
ADORA1, ALOX15, APP, AR, BCL2, CDC25B, CHRNA3, CHRNA7, DNMT1, DUSP3, DYRK1A, EGFR, ERBB2, FABP4, FLT3, GBA, GRM1, GRM5, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, KIT, MMP9, NUAK1, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SRC, TEK, XDH |
7.38116 |
|
[BP] GO:0030335 |
positive regulation of cell migration
|
ALOX12, APP, BCL2, EGFR, F3, HIF1A, IGF1R, INSR, KDR, KIT, MET, MMP9, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TEK, TERT |
7.31706 |
|
[BP] GO:0006631 |
fatty acid metabolic process
|
ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, PPARA, PPARG, PTGS1, PTGS2, TBXAS1 |
7.30516 |
|
[BP] GO:0051240 |
positive regulation of multicellular organismal process
|
ADRB1, ALOX12, APP, AR, AXL, BCL2, CA2, CHRM3, CHRNA7, CNR1, CYP1B1, EGFR, ESRRB, F3, GBA, HCAR2, HIF1A, HSPA1A, KDR, KIT, MET, MMP12, MMP9, PIM1, PPARG, PRKCA, PRKCB, PRKCE, PTGS2, SLC1A1, SMAD3, SRC, TEK, TERT, TRPV1 |
7.29622 |
|
[BP] GO:0007154 |
None
|
ADORA1, ADRB1, AR, AXL, BCL2, CACNA1C, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA3, CNR1, ESR2, GBA, GRIA2, GRIK5, GRM1, GRM3, GRM5, PGR, PPARG, PRKCG, PTGS2, SLC1A1, TEK, TRPV1 |
7.25162 |
|
[BP] GO:0010817 |
regulation of hormone levels
|
ACHE, ADORA1, AKR1B1, CACNA1C, CHRNA3, CNR1, CYP19A1, CYP1A1, CYP1B1, EGFR, ESR1, HCAR2, HIF1A, HSD11B1, HSD11B2, HSD17B1, HSD17B2, PRKCA, PRKCE, SLC22A1 |
7.1385 |
|
[BP] GO:2000147 |
positive regulation of cell motility
|
ALOX12, APP, BCL2, EGFR, F3, HIF1A, IGF1R, INSR, KDR, KIT, MET, MMP9, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TEK, TERT |
7.08085 |
|
[BP] GO:0044057 |
None
|
ADORA1, ADORA3, ADRB1, CACNA1C, CHRM1, CHRM2, CHRM3, CHRNA3, EGFR, GAA, GBA, GPR35, GRM1, HCAR2, KIT, PRKCA, PTGS2, SLC1A1, SMAD3, TRPV1 |
7.00382 |
|
[BP] GO:0044238 |
primary metabolic process
|
ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AR, AURKB, AXL, BACE1, BCL2, CBR1, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DAO, DNMT1, DUSP3, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUCA1, FUT7, GAA, GBA, GBA2, GLO1, HIF1A, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MGAM, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TERT, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH |
6.9999 |
|
[BP] GO:0007215 |
None
|
APP, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 |
6.98267 |
|
[BP] GO:0051272 |
positive regulation of cellular component movement
|
ALOX12, APP, BCL2, EGFR, F3, HIF1A, IGF1R, INSR, KDR, KIT, MET, MMP9, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TEK, TERT |
6.89637 |
|
[BP] GO:0032844 |
regulation of homeostatic process
|
ADORA1, AURKB, BCL2, CA2, CA7, CACNA1C, CDK6, CNR1, EGFR, HCAR2, HIF1A, KDR, PIK3CB, PRKCE, PTGS2, SRC, TNKS, TNKS2, TRPV1 |
6.83834 |
|
[BP] GO:0032787 |
None
|
ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, GBA2, GLO1, HIF1A, PPARA, PPARG, PTGS1, PTGS2, TBXAS1 |
6.78346 |
|
[BP] GO:0043408 |
regulation of MAPK cascade
|
ADORA1, ALOX15, APP, AR, CHRNA7, DUSP3, EGFR, ERBB2, FLT3, GBA, GRM1, IGF1R, INSR, KDR, KIT, PIK3CB, PRKCA, PRKCD, PRKCE, PTPN1, SRC, TEK, XDH |
6.78346 |
|
[BP] GO:0006796 |
phosphate-containing compound metabolic process
|
ACHE, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DUSP3, DYRK1A, EGFR, ERBB2, FLT3, HSP90AA1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, PIM1, POLB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SRC, TEK, TNKS, XDH |
6.74836 |
|
[BP] GO:0001932 |
regulation of protein phosphorylation
|
ADORA1, ALOX15, APP, AR, BCL2, CDC25B, CHRNA3, CHRNA7, DUSP3, EGFR, ERBB2, FABP4, FLT3, GBA, GRM1, GRM5, HSP90AB1, IGF1R, INSR, KDR, KIT, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TEK, XDH |
6.68082 |
|
[BP] GO:0040017 |
positive regulation of locomotion
|
ALOX12, APP, BCL2, EGFR, F3, HIF1A, IGF1R, INSR, KDR, KIT, MET, MMP9, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TEK, TERT |
6.66152 |
|
[BP] GO:0016310 |
phosphorylation
|
APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DYRK1A, EGFR, ERBB2, FLT3, HSP90AA1, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TNKS |
6.63543 |
|
[BP] GO:0007166 |
cell surface receptor signaling pathway
|
ADORA1, ADORA3, APP, AXL, BCL2, CA1, CSNK2A1, EGFR, ERBB2, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSP90AA1, HSP90AB1, IGF1R, INSR, KDR, KIT, MET, MMP2, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TRPV1 |
6.63231 |
|
[BP] GO:0048856 |
anatomical structure development
|
ACHE, ADORA1, AKR1B1, ALOX15, ALPL, APP, AR, AXL, BCL2, CA2, CACNA1C, CDK6, CHRM1, CHRM2, CHRM3, CHRNA3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, DYRK1A, EDNRA, EGFR, ERBB2, ESR1, ESRRA, ESRRB, FLT3, GAA, GBA2, HIF1A, HSD11B1, HSD17B2, HSP90AB1, INSR, KDR, KIT, MMP9, PGR, PIK3CA, PIM1, POLB, PPARA, PPARG, PTGS2, RORC, SMAD3, SRC, TEK, TYR |
6.62036 |
|
[BP] GO:0019222 |
regulation of metabolic process
|
ACHE, ADORA1, ADORA3, ADRB1, ALOX15, APEX1, APP, AR, AURKB, BCL2, CA9, CDC25B, CDK6, CHRM5, CHRNA3, CHRNA7, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DNMT1, DUSP3, DYRK1A, EDNRA, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GBA, GLO1, GRM1, GRM3, GRM5, GRM8, HCAR2, HIF1A, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIK3CA, PIK3CB, PIM1, POLA1, PPARA, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH |
6.57804 |
|
[BP] GO:0051338 |
regulation of transferase activity
|
ADORA1, APP, AURKB, CDC25B, CHRNA3, CHRNA7, DUSP3, EGFR, ERBB2, FABP4, FLT3, GBA, GRM1, GRM5, HSP90AA1, HSP90AB1, IGF1R, INSR, KIT, PIK3CA, PIK3CB, PPARG, PRKCD, PTPN1, SRC, TEK, TNKS |
6.56289 |
|
[BP] GO:0048585 |
negative regulation of response to stimulus
|
ADORA1, ALOX12, ALOX15, AR, BCL2, CDK6, CNR1, CNR2, CYP19A1, DUSP3, DYRK1A, EGFR, ERBB2, ESR1, ESR2, GBA, HIF1A, HSPA1A, IGF1R, MET, MMP12, MMP9, PPARA, PPARG, PRKCB, PRKCD, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH |
6.51539 |
|
[BP] GO:0009755 |
hormone-mediated signaling pathway
|
AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, NR3C2, PGR, PPARA, PPARG, RORC, SRC |
6.5103 |
|
[BP] GO:0006950 |
response to stress
|
ACHE, ADORA1, ADORA3, ADRB1, AKR1B1, ALOX15, APEX1, APP, AXL, BCL2, CA2, CA9, CHRNA7, CNR2, CYP1A1, CYP1A2, CYP1B1, EDNRA, EGFR, ERBB2, GBA, HIF1A, HSD11B2, HSP90AA1, HSP90AB1, HSPA1A, KIT, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, POLA1, POLB, PPARA, PPARG, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1 |
6.50256 |
|
[BP] GO:0071495 |
cellular response to endogenous stimulus
|
AKR1B1, APEX1, APP, AR, DNMT1, EGFR, ERBB2, ESR1, FLT3, GRM5, IGF1R, INSR, KIT, MMP2, NR3C1, PPARG, PRKCD, PRKCE, PTGS2, SMAD3, SRC, TRPV1 |
6.4922 |
|
[BP] GO:2000377 |
regulation of reactive oxygen species metabolic process
|
BCL2, CYP1B1, EGFR, HIF1A, HSP90AA1, HSP90AB1, INSR, PRKCD, PTGS2, SMAD3, TRPV1, XDH |
6.45908 |
|
[BP] GO:0001775 |
cell activation
|
ALOX5, APP, AXL, BCL2, EGFR, FLT3, FUCA1, FUT7, GAA, HSP90AA1, HSP90AB1, HSPA1A, KIT, MGAM, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, RORC, SMAD3, SRC, TRPV1 |
6.43025 |
|
[BP] GO:0007193 |
None
|
ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, GRM1, GRM3, GRM5, GRM8 |
6.40204 |
|
[BP] GO:0042391 |
None
|
ADORA1, APP, BCL2, CACNA1C, CHRNA3, CHRNA7, CNR1, CNR2, GBA, GPR35, GRIA2, GRIA4, GRIK5, GRM5, KDR, SRC, TRPV1 |
6.3808 |
|
[BP] GO:0043410 |
positive regulation of MAPK cascade
|
ADORA1, ALOX15, APP, AR, CHRNA7, EGFR, ERBB2, FLT3, GRM1, INSR, KDR, KIT, PIK3CB, PRKCA, PRKCE, PTPN1, SRC, TEK, XDH |
6.3808 |
|
[BP] GO:1901652 |
response to peptide
|
AKR1B1, APEX1, APP, CHRNA7, FABP3, GRM5, HSD11B2, IGF1R, INSR, PPARA, PPARG, PRKCD, PTGS2, SRC, TEK, TRPV1 |
6.37618 |
|
[BP] GO:0001505 |
regulation of neurotransmitter levels
|
ACHE, CHRNA3, CYP1B1, EGFR, GRIK5, HSP90AA1, HSP90AB1, INSR, PTGS2, SLC1A1, SLC22A2, SLC22A3, SMAD3, TRPV1 |
6.36695 |
|
[BP] GO:0071407 |
cellular response to organic cyclic compound
|
ALPL, APEX1, APP, AR, CYP1A1, CYP1B1, EGFR, ESR1, FLT3, HSP90AB1, NR3C1, PPARG, PTGS2, RORC, SRC, TRPV1 |
6.34817 |
|
[BP] GO:1904018 |
positive regulation of vasculature development
|
ALOX12, CHRNA7, CYP1B1, F3, HIF1A, KDR, KIT, PRKCA, PRKCB, PTGS2, TEK, TERT |
6.31408 |
|
[BP] GO:0030522 |
intracellular receptor signaling pathway
|
AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, PGR, PIM1, PPARA, PPARG, RORC, SRC |
6.31408 |
|
[BP] GO:0009966 |
regulation of signal transduction
|
ADORA1, ADRB1, AKR1B1, ALOX15, APP, AR, AURKB, AXL, BCL2, CHRNA7, CSNK2A1, CYP1B1, DUSP3, DYRK1A, EGFR, ERBB2, ESR1, ESR2, F3, FLT3, GBA, GPR35, GRM1, HIF1A, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH |
6.28455 |
|
[BP] GO:0006793 |
phosphorus metabolic process
|
ACHE, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DUSP3, DYRK1A, EGFR, ERBB2, FLT3, HSP90AA1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, PIM1, POLB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SRC, TEK, TNKS, XDH |
6.25996 |
|
[BP] GO:0080090 |
regulation of primary metabolic process
|
ADORA1, ADORA3, ADRB1, ALOX15, APEX1, APP, AR, AURKB, BCL2, CA9, CDC25B, CHRM5, CHRNA3, CHRNA7, CNR1, CSNK2A1, CYP1A1, CYP1B1, DNMT1, DUSP3, DYRK1A, EDNRA, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GBA, GLO1, GRM1, GRM3, GRM5, GRM8, HCAR2, HIF1A, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIK3CA, PIK3CB, PIM1, POLA1, PPARA, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH |
6.2302 |
|
[BP] GO:0019216 |
regulation of lipid metabolic process
|
ADORA1, CHRM5, CNR1, CYP1A1, FABP3, FLT3, HCAR2, KIT, PPARA, PPARG, PRKCD, PRKCE, PTGS2, RORC, SRC, TEK |
6.15957 |
|
[BP] GO:0007187 |
None
|
ADORA1, ADRB1, CHRM1, CHRM2, CHRM3, CHRM5, CNR1, CNR2, GRM1, GRM3, GRM5, GRM8 |
6.11091 |
|
[BP] GO:0051966 |
regulation of synaptic transmission, glutamatergic
|
ADORA1, CNR1, EGFR, GRM1, GRM3, GRM5, GRM8, PTGS2 |
6.03296 |
|
[BP] GO:0008217 |
None
|
ADORA1, ADRB1, AR, CNR1, EDNRA, HSD11B2, PPARA, PPARG, PTGS1, PTGS2, SMAD3 |
6.01327 |
|
[BP] GO:0031324 |
negative regulation of cellular metabolic process
|
APEX1, APP, AR, AURKB, BCL2, CHRNA7, CNR1, CSNK2A1, CYP2D6, DNMT1, DUSP3, DYRK1A, EDNRA, ESR1, ESR2, ESRRA, FABP4, GBA, GRM3, GRM8, HIF1A, HSP90AB1, HSPA1A, IGF1R, MET, MMP12, MMP9, NR3C1, PIK3CA, PPARA, PPARG, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TRPV1, XDH |
6.01186 |
|
[BP] GO:0006820 |
anion transport
|
ABCB1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA, PPARG, SLC1A1, SLC22A1, SLC22A2, SLC22A3, TRPV1 |
5.97422 |
|
[BP] GO:0095500 |
None
|
CHRM1, CHRM2, CHRM3, CHRM5, CHRNA3, CHRNA7 |
5.95761 |
|
[BP] GO:1903831 |
None
|
CHRM1, CHRM2, CHRM3, CHRM5, CHRNA3, CHRNA7 |
5.95761 |
|
[BP] GO:0031323 |
regulation of cellular metabolic process
|
ACHE, ADORA1, ADORA3, ADRB1, ALOX15, APEX1, APP, AR, AURKB, BCL2, CA9, CDC25B, CHRM5, CHRNA3, CHRNA7, CNR1, CSNK2A1, CYP1B1, CYP2D6, DNMT1, DUSP3, DYRK1A, EDNRA, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GBA, GLO1, GRM1, GRM3, GRM5, GRM8, HIF1A, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIK3CA, PIK3CB, PIM1, POLA1, PPARA, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH |
5.95744 |
|
[BP] GO:0051897 |
positive regulation of protein kinase B signaling
|
AXL, EGFR, ERBB2, F3, INSR, KIT, MET, PIK3CA, PIK3CB, SRC, TEK |
5.94257 |
|
[BP] GO:0007197 |
None
|
CHRM1, CHRM2, CHRM3, CHRM5 |
5.89735 |
|
[BP] GO:0045766 |
positive regulation of angiogenesis
|
ALOX12, CHRNA7, CYP1B1, F3, HIF1A, KDR, PRKCA, PRKCB, PTGS2, TEK, TERT |
5.88966 |
|
[BP] GO:1901342 |
regulation of vasculature development
|
ALOX12, CHRNA7, CYP1B1, ERBB2, F3, HIF1A, KDR, KIT, PPARG, PRKCA, PRKCB, PTGS2, TEK, TERT, XDH |
5.8735 |
|
[BP] GO:0035690 |
cellular response to drug
|
AKR1B1, APEX1, AXL, CDK6, CYP1B1, EGFR, HSP90AB1, KDR, NR3C1, PRKCD, PRKCE, PTGS2, SRC, TRPV1 |
5.8735 |
|
[BP] GO:1904407 |
positive regulation of nitric oxide metabolic process
|
EGFR, HSP90AA1, HSP90AB1, INSR, PTGS2, SMAD3, TRPV1 |
5.84701 |
|
[BP] GO:0045429 |
positive regulation of nitric oxide biosynthetic process
|
EGFR, HSP90AA1, HSP90AB1, INSR, PTGS2, SMAD3, TRPV1 |
5.84701 |
|
[BP] GO:0007188 |
None
|
ADORA1, ADRB1, CHRM1, CHRM2, CHRM3, CHRM5, CNR1, GRM1, GRM3, GRM5, GRM8 |
5.84519 |
|
[BP] GO:0048511 |
rhythmic process
|
AXL, BCL2, CSNK2A1, DYRK1A, EGFR, ESR1, KIT, PGR, PPARA, PPARG, PRKCG, RORC, SRC, TOP2A |
5.84519 |
|
[BP] GO:0051347 |
positive regulation of transferase activity
|
ADORA1, AURKB, CDC25B, CHRNA3, CHRNA7, EGFR, ERBB2, FLT3, GRM1, GRM5, HSP90AA1, HSP90AB1, INSR, KIT, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC, TEK, TNKS |
5.8362 |
|
[BP] GO:0007169 |
transmembrane receptor protein tyrosine kinase signaling pathway
|
AXL, EGFR, ERBB2, FLT3, HSP90AA1, IGF1R, INSR, KDR, KIT, MET, MMP2, MMP9, PIK3CA, PIK3CB, PRKCA, PTPN1, SRC, TEK |
5.8362 |
|
[BP] GO:2000379 |
positive regulation of reactive oxygen species metabolic process
|
EGFR, HSP90AA1, HSP90AB1, INSR, PRKCD, PTGS2, SMAD3, TRPV1, XDH |
5.8362 |
|
[BP] GO:0045834 |
positive regulation of lipid metabolic process
|
FABP3, FLT3, KIT, PPARA, PPARG, PRKCD, PRKCE, PTGS2, SRC, TEK |
5.77619 |
|
[BP] GO:0002682 |
regulation of immune system process
|
ADORA1, ALOX15, APP, AXL, BCL2, CA2, CDK6, CNR1, CNR2, CYP19A1, DUSP3, ERBB2, ESR1, ESRRA, HCAR2, HIF1A, HSP90AA1, HSP90AB1, HSPA1A, KIT, MMP12, MMP2, PIK3CA, PIK3CB, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PTPN1, SMAD3, SRC |
5.74824 |
|
[BP] GO:0006367 |
transcription initiation from RNA polymerase II promoter
|
AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, NR3C2, PGR, PPARA, PPARG, RORC |
5.74358 |
|
[BP] GO:0043405 |
regulation of MAP kinase activity
|
ADORA1, CHRNA7, DUSP3, EGFR, ERBB2, FLT3, GBA, GRM1, IGF1R, INSR, KIT, PIK3CB, PRKCD, PTPN1, SRC |
5.74329 |
|
[BP] GO:0071704 |
organic substance metabolic process
|
ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AR, AURKB, AXL, BACE1, BCL2, CBR1, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DAO, DNMT1, DUSP3, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUCA1, FUT7, GAA, GBA, GBA2, GLO1, HIF1A, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MGAM, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TERT, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH |
5.71399 |
|
[BP] GO:0009894 |
regulation of catabolic process
|
ADORA1, APEX1, BCL2, CNR1, CSNK2A1, EGFR, ESRRB, GBA, HCAR2, HIF1A, HSP90AB1, HSPA1A, INSR, KDR, MET, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3 |
5.62453 |
|
[BP] GO:0009636 |
response to toxic substance
|
AKR1B1, ALPL, APEX1, AXL, BCL2, CHRNA7, CNR1, CNR2, CYP1A1, CYP1B1, HSP90AA1, KDR, POLB, PRKCD, PRKCE, SRC |
5.61174 |
|
[BP] GO:0006811 |
None
|
ABCB1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CHRM5, CHRNA3, CHRNA7, FABP3, GRIA2, GRIA4, GRIK5, PPARA, PPARG, PRKCB, PRKCE, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, TRPV1 |
5.60136 |
|
[BP] GO:0043549 |
regulation of kinase activity
|
ADORA1, APP, CDC25B, CHRNA3, CHRNA7, DUSP3, EGFR, ERBB2, FABP4, FLT3, GBA, GRM1, GRM5, HSP90AB1, IGF1R, INSR, KIT, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC, TEK |
5.57525 |
|
[BP] GO:0009987 |
cellular process
|
ABCB1, ACHE, ADORA1, ADORA3, ADRB1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AR, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CBR1, CDC25B, CDK6, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA3, CHRNA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DAO, DNMT1, DUSP3, DYRK1A, EDNRA, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUCA1, FUT7, GAA, GBA, GBA2, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HIF1A, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MGAM, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NR3C2, NUAK1, PGR, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SLC22A1, SLC22A2, SMAD3, SRC, TBXAS1, TEK, TERT, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH |
5.57517 |
|
[BP] GO:0019725 |
cellular homeostasis
|
APEX1, APP, BCL2, CA2, CA7, CACNA1C, CHRNA7, EDNRA, ESR1, GAA, GPR35, GRIK5, GRM1, GRM5, HIF1A, PIK3CA, PIK3CB, POLA1, PRKCB, PRKCE, SMAD3, TRPV1 |
5.51174 |
|
[BP] GO:0051896 |
regulation of protein kinase B signaling
|
AXL, EGFR, ERBB2, F3, INSR, KIT, MET, PIK3CA, PIK3CB, SRC, TEK, XDH |
5.50392 |
|
[BP] GO:0045859 |
regulation of protein kinase activity
|
ADORA1, APP, CDC25B, CHRNA3, CHRNA7, DUSP3, EGFR, ERBB2, FABP4, FLT3, GBA, GRM1, GRM5, HSP90AB1, IGF1R, INSR, KIT, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC |
5.48637 |
|
[BP] GO:0007207 |
None
|
CHRM1, CHRM2, CHRM3, CHRM5 |
5.47925 |
|
[BP] GO:0051054 |
positive regulation of DNA metabolic process
|
AURKB, DNMT1, EGFR, HSP90AA1, HSP90AB1, IGF1R, INSR, PRKCD, PRKCG, SRC, TNKS, TNKS2 |
5.4662 |
|
[BP] GO:0044092 |
negative regulation of molecular function
|
ADORA3, APP, AURKB, CNR1, CNR2, CSNK2A1, CYP1B1, CYP2D6, DUSP3, ESR1, FABP4, GBA, GPR35, GRM3, IGF1R, MET, MMP9, PIM1, PPARA, PPARG, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TNKS |
5.44175 |
|
[BP] GO:0051130 |
positive regulation of cellular component organization
|
ALOX15, APP, AR, AURKB, AXL, BCL2, CNR1, DNMT1, ESR1, GBA, HIF1A, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP9, PPARG, PRKCD, PRKCE, SMAD3, SRC, TEK, TNKS, TNKS2 |
5.4055 |
|
[BP] GO:0050801 |
ion homeostasis
|
APP, BCL2, CA12, CA2, CA7, CACNA1C, CHRNA7, EDNRA, EGFR, ESR1, FABP3, GPR35, GRM1, GRM5, HIF1A, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 |
5.34086 |
|
[BP] GO:0018193 |
peptidyl-amino acid modification
|
AURKB, AXL, BCL2, CSNK2A1, DYRK1A, EGFR, ERBB2, FLT3, HSP90AA1, IGF1R, INSR, KDR, KIT, MET, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TNKS, TOP2A |
5.33411 |
|
[BP] GO:0033674 |
positive regulation of kinase activity
|
ADORA1, CDC25B, CHRNA3, CHRNA7, EGFR, ERBB2, FLT3, GRM1, GRM5, HSP90AB1, INSR, KIT, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC, TEK |
5.26452 |
|
[BP] GO:0051050 |
positive regulation of transport
|
ABCB1, ACHE, ADORA1, APP, AXL, BCL2, CA2, CHRM1, CYP19A1, EGFR, ERBB2, HCAR2, HIF1A, HSP90AB1, INSR, MMP12, PPARG, PRKCD, PRKCE, PTGS2, SMAD3, SRC, TERT, TRPV1 |
5.23277 |
|
[BP] GO:0060078 |
None
|
ADORA1, CHRNA3, CHRNA7, GRIA2, GRIA4, GRIK5, GRM5, TRPV1 |
5.20559 |
|
[BP] GO:0051128 |
regulation of cellular component organization
|
ALOX12, ALOX15, APP, AR, AURKB, AXL, BCL2, CHRNA3, CHRNA7, CNR1, CSNK2A1, DNMT1, EGFR, ERBB2, ESR1, ESR2, GBA, GRIK5, HIF1A, HSP90AA1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP9, PIK3CB, PPARG, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A |
5.20093 |
|
[BP] GO:0010648 |
negative regulation of cell communication
|
ACHE, ADORA1, AR, BCL2, CNR2, DUSP3, DYRK1A, EGFR, ERBB2, ESR1, ESR2, GBA, GPR35, HIF1A, HSPA1A, IGF1R, MET, MMP12, MMP9, PPARG, PRKCB, PRKCD, PTGS2, PTPN1, SMAD3, SRC, TERT, XDH |
5.19345 |
|
[BP] GO:0051171 |
regulation of nitrogen compound metabolic process
|
ADORA1, ADORA3, ADRB1, ALOX15, APEX1, APP, AR, AURKB, BCL2, CA9, CDC25B, CHRNA3, CHRNA7, CSNK2A1, CYP1B1, DNMT1, DUSP3, DYRK1A, EDNRA, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GBA, GLO1, GRM1, GRM3, GRM5, GRM8, HIF1A, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIK3CA, PIK3CB, PIM1, POLA1, PPARA, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH |
5.19345 |
|
[BP] GO:1903428 |
positive regulation of reactive oxygen species biosynthetic process
|
EGFR, HSP90AA1, HSP90AB1, INSR, PTGS2, SMAD3, TRPV1 |
5.17181 |
|
[BP] GO:0023057 |
negative regulation of signaling
|
ACHE, ADORA1, AR, BCL2, CNR2, DUSP3, DYRK1A, EGFR, ERBB2, ESR1, ESR2, GBA, GPR35, HIF1A, HSPA1A, IGF1R, MET, MMP12, MMP9, PPARG, PRKCB, PRKCD, PTGS2, PTPN1, SMAD3, SRC, TERT, XDH |
5.16902 |
|
[BP] GO:0009891 |
positive regulation of biosynthetic process
|
ADRB1, APP, AR, AURKB, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FABP3, GBA, HIF1A, HSP90AA1, HSP90AB1, IGF1R, INSR, KDR, MET, MMP12, NR3C1, PGR, PPARA, PPARG, PRKCD, PTGS2, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TOP2A, TRPV1 |
5.15578 |
|
[BP] GO:0009698 |
phenylpropanoid metabolic process
|
CYP1A1, CYP2A13, CYP2A6, CYP2D6 |
5.15002 |
|
[BP] GO:0009804 |
coumarin metabolic process
|
CYP1A1, CYP2A13, CYP2A6, CYP2D6 |
5.15002 |
|
[BP] GO:0045935 |
positive regulation of nucleobase-containing compound metabolic process
|
ADRB1, APP, AR, AURKB, DNMT1, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, HIF1A, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, MET, MMP12, NR3C1, PGR, PPARA, PPARG, PRKCD, PRKCG, PTPN1, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TOP2A |
5.14574 |
|
[BP] GO:0030168 |
platelet activation
|
AXL, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC |
5.14317 |
|
[BP] GO:0032228 |
regulation of synaptic transmission, GABAergic
|
ADORA1, CA2, CA7, CNR1, CNR2, PRKCE |
5.134 |
|
[BP] GO:0007267 |
None
|
ADORA1, ADRB1, AR, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA3, CNR1, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, PGR, PRKCG, SLC1A1, TEK |
5.12653 |
|
[BP] GO:0050678 |
None
|
AR, CDK6, EGFR, ERBB2, F3, HIF1A, KDR, MMP12, PGR, PPARG, PRKCA, SMAD3, TEK, XDH |
5.11601 |
|
[BP] GO:0023052 |
None
|
ADORA1, ADRB1, AR, CACNA1C, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA3, CNR1, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, PGR, PRKCG, SLC1A1, TEK |
5.07952 |
|
[BP] GO:0003008 |
None
|
ADORA1, ADRB1, AKR1B1, APP, BCL2, CHRM1, CHRM3, CHRM5, CHRNA7, CNR1, CNR2, CYP1B1, EDNRA, EGFR, GAA, GRM1, GRM5, GRM8, HIF1A, HSD11B2, INSR, KIT, PIK3CA, PRKCG, PTGS2, SRC, TEK, TRPV1, TYR |
5.07952 |
|
[BP] GO:0006805 |
xenobiotic metabolic process
|
CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6, HSP90AB1, NQO2, PTGS1, RORC |
5.02054 |
|
[BP] GO:0050728 |
negative regulation of inflammatory response
|
ADORA1, CNR2, CYP19A1, GBA, PPARA, PPARG, PRKCD, SMAD3, TEK |
4.98941 |
|
[BP] GO:0032268 |
regulation of cellular protein metabolic process
|
ADORA1, ALOX15, APP, AR, BCL2, CDC25B, CHRNA3, CHRNA7, CSNK2A1, DNMT1, DUSP3, DYRK1A, EGFR, ERBB2, ESR1, F3, FABP4, FLT3, GBA, GRM1, GRM5, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, KIT, MMP9, NUAK1, PIK3CA, PIK3CB, PPARG, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH |
4.97763 |
|
[BP] GO:0016137 |
None
|
AKR1B1, AKR1B10, FUCA1, GBA, GBA2 |
4.97296 |
|
[BP] GO:0098771 |
inorganic ion homeostasis
|
APP, BCL2, CA12, CA2, CA7, CACNA1C, CHRNA7, EDNRA, EGFR, ESR1, GPR35, GRM1, GRM5, HIF1A, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 |
4.97296 |
|
[BP] GO:0045860 |
positive regulation of protein kinase activity
|
ADORA1, CDC25B, CHRNA3, CHRNA7, EGFR, ERBB2, FLT3, GRM1, GRM5, HSP90AB1, INSR, KIT, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC |
4.97296 |
|
[BP] GO:0032101 |
regulation of response to external stimulus
|
ADORA1, ALOX12, CNR1, CNR2, CYP19A1, EGFR, ESR1, F3, FABP4, GBA, KDR, MET, MMP12, PPARA, PPARG, PRKCA, PRKCD, PRKCG, PTGS2, SMAD3, TEK |
4.93865 |
|
[BP] GO:0051098 |
regulation of binding
|
APP, AURKB, BCL2, CYP2D6, HSP90AB1, MET, MMP9, PPARA, PPARG, PRKCD, SMAD3, SRC, TERT, TNKS |
4.92844 |
|
[BP] GO:0045428 |
regulation of nitric oxide biosynthetic process
|
EGFR, HSP90AA1, HSP90AB1, INSR, PTGS2, SMAD3, TRPV1 |
4.92617 |
|
[BP] GO:0019752 |
carboxylic acid metabolic process
|
ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DAO, FABP3, GBA2, GLO1, HIF1A, PIM1, PPARA, PPARG, PTGS1, PTGS2, TBXAS1, TYR |
4.9117 |
|
[BP] GO:0031347 |
regulation of defense response
|
ADORA1, CNR1, CNR2, CYP19A1, EGFR, ESR1, FABP4, GBA, HSP90AB1, HSPA1A, MMP12, MMP2, PPARA, PPARG, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK |
4.90841 |
|
[BP] GO:0055082 |
cellular chemical homeostasis
|
APP, BCL2, CA2, CA7, CACNA1C, CHRNA7, EDNRA, ESR1, GPR35, GRIK5, GRM1, GRM5, HIF1A, PIK3CA, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 |
4.86937 |
|
[BP] GO:0065007 |
biological regulation
|
ABCB1, ACHE, ADORA1, ADORA3, ADRB1, AKR1B1, ALOX12, ALOX15, APEX1, APP, AR, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA7, CA9, CACNA1C, CDC25B, CDK6, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA3, CHRNA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DNMT1, DUSP3, DYRK1A, EDNRA, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GAA, GBA, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HIF1A, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH |
4.86817 |
|
[BP] GO:0031328 |
positive regulation of cellular biosynthetic process
|
ADRB1, APP, AR, AURKB, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FABP3, GBA, HIF1A, HSP90AA1, HSP90AB1, IGF1R, INSR, MET, MMP12, NR3C1, PGR, PPARA, PPARG, PRKCD, PTGS2, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TOP2A, TRPV1 |
4.84564 |
|
[BP] GO:0045765 |
regulation of angiogenesis
|
ALOX12, CHRNA7, CYP1B1, ERBB2, F3, HIF1A, KDR, PPARG, PRKCA, PRKCB, PTGS2, TEK, TERT |
4.83213 |
|
[BP] GO:0099536 |
None
|
CHRM1, CHRM2, CHRM3, CHRM5, CHRNA3, CNR1, GRIA2, GRIK5, GRM1, GRM3, GRM5, PRKCG, SLC1A1 |
4.80338 |
|
[BP] GO:0099537 |
None
|
CHRM1, CHRM2, CHRM3, CHRM5, CHRNA3, CNR1, GRIA2, GRIK5, GRM1, GRM3, GRM5, PRKCG, SLC1A1 |
4.80338 |
|
[BP] GO:0006352 |
DNA-templated transcription, initiation
|
AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, NR3C2, PGR, PPARA, PPARG, RORC |
4.75194 |
|
[BP] GO:0003006 |
developmental process involved in reproduction
|
ALPL, AR, AXL, BCL2, CDC25B, CYP19A1, EGFR, ESR1, ESRRB, HIF1A, HSD17B2, HSP90AB1, INSR, KIT, PGR, PPARG, PTGS2, SRC |
4.74965 |
|
[BP] GO:0010634 |
positive regulation of epithelial cell migration
|
HIF1A, KDR, MET, MMP9, PRKCA, PRKCE, PTGS2, SRC, TEK |
4.71012 |
|
[BP] GO:0007610 |
None
|
APP, BCL2, CHRNA3, CHRNA7, CNR1, EGFR, GAA, GRM1, GRM5, HIF1A, INSR, KIT, PPARA, PRKCE, PRKCG, PTGS2, TRPV1 |
4.69862 |
|
[BP] GO:0072507 |
divalent inorganic cation homeostasis
|
APP, BCL2, CACNA1C, CHRNA7, EDNRA, EGFR, ESR1, GPR35, GRM1, GRM5, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 |
4.68991 |
|
[BP] GO:0018105 |
peptidyl-serine phosphorylation
|
AURKB, BCL2, DYRK1A, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TNKS |
4.68991 |
|
[BP] GO:0007167 |
enzyme linked receptor protein signaling pathway
|
AXL, EGFR, ERBB2, FLT3, HSP90AA1, IGF1R, INSR, KDR, KIT, MET, MMP2, MMP9, PIK3CA, PIK3CB, PRKCA, PTPN1, SMAD3, SRC, TEK |
4.68231 |
|
[BP] GO:0007196 |
None
|
GRM1, GRM3, GRM5, GRM8 |
4.65864 |
|
[BP] GO:0038128 |
None
|
EGFR, ERBB2, HSP90AA1, PIK3CA, PRKCA, SRC |
4.65169 |
|
[BP] GO:0019373 |
epoxygenase P450 pathway
|
CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 |
4.64621 |
|
[BP] GO:0051234 |
None
|
ABCB1, ACHE, ADORA1, ALOX15, ALOX5, APP, AR, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CHRM1, CHRM3, CHRM5, CHRNA3, CHRNA7, EDNRA, EGFR, FABP3, FUCA1, GAA, GRIA2, GRIA4, GRIK5, HIF1A, HSP90AA1, HSP90AB1, HSPA1A, KIT, MGAM, MMP12, MMP9, PPARA, PPARG, PRKCB, PRKCD, PRKCE, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SRC, TERT, TNKS, TRPV1, XDH |
4.6399 |
|
[BP] GO:0006855 |
None
|
ABCB1, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2 |
4.61196 |
|
[BP] GO:0006940 |
None
|
ADORA1, CHRM1, CHRM2, CHRM3, CHRNA3, KIT, PTGS2 |
4.5665 |
|
[BP] GO:0031348 |
negative regulation of defense response
|
ADORA1, CNR2, CYP19A1, GBA, MMP12, PPARA, PPARG, PRKCD, SMAD3, TEK |
4.56104 |
|
[BP] GO:0010038 |
response to metal ion
|
ALOX15, APP, BCL2, CA2, CYP1A1, CYP1A2, EGFR, FABP4, HIF1A, KIT, MMP9, PTGS2, TERT |
4.50972 |
|
[BP] GO:0051172 |
None
|
APEX1, APP, AR, AURKB, CHRNA7, CSNK2A1, DNMT1, DUSP3, DYRK1A, EDNRA, EGFR, ESR1, ESR2, ESRRA, FABP4, GBA, GRM3, GRM8, HSP90AB1, HSPA1A, IGF1R, MMP12, MMP9, NR3C1, PPARA, PPARG, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TRPV1, XDH |
4.4943 |
|
[BP] GO:0048545 |
response to steroid hormone
|
ALPL, AR, BCL2, CA2, EGFR, FLT3, GBA, HSD11B2, NR3C1, PTGS2, SRC |
4.49366 |
|
[BP] GO:0055080 |
cation homeostasis
|
APP, BCL2, CA2, CA7, CACNA1C, CHRNA7, EDNRA, EGFR, ESR1, GPR35, GRM1, GRM5, HIF1A, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 |
4.47865 |
|
[BP] GO:2001225 |
regulation of chloride transport
|
ABCB1, CA2, CA7, GRM5 |
4.45702 |
|
[BP] GO:0030003 |
cellular cation homeostasis
|
APP, BCL2, CA2, CA7, CACNA1C, CHRNA7, EDNRA, ESR1, GPR35, GRM1, GRM5, HIF1A, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 |
4.43115 |
|
[BP] GO:0006874 |
cellular calcium ion homeostasis
|
APP, BCL2, CACNA1C, CHRNA7, EDNRA, ESR1, GPR35, GRM1, GRM5, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 |
4.43115 |
|
[BP] GO:0050890 |
None
|
ADORA1, APP, CHRM1, CHRNA7, CNR1, EGFR, GRM5, HIF1A, INSR, KIT, PRKCG, PTGS2 |
4.43085 |
|
[BP] GO:0071900 |
regulation of protein serine/threonine kinase activity
|
ADORA1, CHRNA7, DUSP3, EGFR, ERBB2, FLT3, GBA, GRM1, HSP90AB1, IGF1R, INSR, KIT, PIK3CB, PRKCD, PTPN1, SRC |
4.42691 |
|
[BP] GO:1901654 |
None
|
AKR1B1, AR, CA9, CSNK2A1, EGFR, GBA, NR3C1, PPARG, PRKCE, SRC |
4.41662 |
|
[BP] GO:1903727 |
positive regulation of phospholipid metabolic process
|
FABP3, FLT3, KIT, PRKCD, SRC, TEK |
4.41662 |
|
[BP] GO:0060079 |
None
|
ADORA1, CHRNA3, CHRNA7, GRIA2, GRIA4, GRIK5, TRPV1 |
4.40674 |
|
[BP] GO:0032846 |
positive regulation of homeostatic process
|
AURKB, CA2, CA7, CNR1, EGFR, HCAR2, HIF1A, PIK3CB, PTGS2, TNKS, TNKS2 |
4.37382 |
|
[BP] GO:0050999 |
None
|
CNR1, CNR2, EGFR, HIF1A, HSP90AA1, TERT |
4.35971 |
|
[BP] GO:0051052 |
regulation of DNA metabolic process
|
AURKB, DNMT1, EGFR, HSP90AA1, HSP90AB1, IGF1R, INSR, PIK3CA, PPARG, PRKCD, PRKCG, SRC, TNKS, TNKS2 |
4.34969 |
|
[BP] GO:0050727 |
regulation of inflammatory response
|
ADORA1, CNR1, CNR2, CYP19A1, EGFR, ESR1, FABP4, GBA, PPARA, PPARG, PRKCD, PTGS2, SMAD3, TEK |
4.34969 |
|
[BP] GO:0050793 |
regulation of developmental process
|
ADRB1, ALOX12, APP, AR, AXL, BCL2, CA2, CDK6, CHRNA3, CHRNA7, CNR1, CYP1B1, EGFR, ERBB2, ESR1, ESRRA, ESRRB, F3, HIF1A, HSP90AB1, INSR, KDR, KIT, NUAK1, PIK3CA, PIM1, PPARA, PPARG, PRKCA, PRKCB, PTGS2, RORC, SMAD3, SRC, TEK, TERT, TNKS2, TRPV1, XDH |
4.30706 |
|
[BP] GO:0006873 |
cellular ion homeostasis
|
APP, BCL2, CA2, CA7, CACNA1C, CHRNA7, EDNRA, ESR1, GPR35, GRM1, GRM5, HIF1A, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 |
4.30422 |
|
[BP] GO:0018209 |
peptidyl-serine modification
|
AURKB, BCL2, DYRK1A, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TNKS |
4.30007 |
|
[BP] GO:0080135 |
regulation of cellular response to stress
|
APP, CDK6, DUSP3, DYRK1A, EGFR, HIF1A, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, MET, NUAK1, PRKCD, PRKCG, PTGS2, PTPN1, TERT, XDH |
4.30007 |
|
[BP] GO:0060255 |
regulation of macromolecule metabolic process
|
ACHE, ADORA1, ADORA3, ALOX15, APEX1, APP, AR, AURKB, BCL2, CA9, CDC25B, CDK6, CHRM5, CHRNA3, CHRNA7, CSNK2A1, CYP1A2, CYP1B1, DNMT1, DUSP3, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP4, FLT3, GBA, GLO1, GRM1, GRM5, HIF1A, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIK3CA, PIK3CB, PIM1, POLA1, PPARA, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH |
4.30007 |
|
[BP] GO:1903725 |
regulation of phospholipid metabolic process
|
CHRM5, FABP3, FLT3, KIT, PRKCD, SRC, TEK |
4.29587 |
|
[BP] GO:0055074 |
calcium ion homeostasis
|
APP, BCL2, CACNA1C, CHRNA7, EDNRA, ESR1, GPR35, GRM1, GRM5, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 |
4.29587 |
|
[BP] GO:0019371 |
None
|
CBR1, PTGS1, PTGS2, TBXAS1 |
4.29404 |
|
[BP] GO:0042445 |
hormone metabolic process
|
ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 |
4.28609 |
|
[BP] GO:0006810 |
None
|
ABCB1, ACHE, ADORA1, ALOX15, ALOX5, APP, AR, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CHRM1, CHRM3, CHRM5, CHRNA3, CHRNA7, EDNRA, FABP3, FUCA1, GAA, GRIA2, GRIA4, GRIK5, HIF1A, HSP90AA1, HSP90AB1, HSPA1A, KIT, MGAM, MMP12, MMP9, PPARA, PPARG, PRKCB, PRKCD, PRKCE, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SRC, TNKS, TRPV1, XDH |
4.28543 |
|
[BP] GO:0071417 |
cellular response to organonitrogen compound
|
AKR1B1, APEX1, APP, DNMT1, EGFR, GRM5, IGF1R, INSR, MMP2, PPARG, PRKCD, PTGS2, SRC, TRPV1 |
4.27507 |
|
[BP] GO:0043436 |
oxoacid metabolic process
|
ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DAO, FABP3, GBA2, GLO1, HIF1A, PIM1, PPARA, PPARG, PTGS1, PTGS2, TBXAS1, TYR |
4.26471 |
|
[BP] GO:0051179 |
None
|
ABCB1, ACHE, ADORA1, ALOX15, ALOX5, APP, AR, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CHRM1, CHRM3, CHRM5, CHRNA3, CHRNA7, EDNRA, EGFR, ESR1, FABP3, FUCA1, GAA, GRIA2, GRIA4, GRIK5, HIF1A, HSP90AA1, HSP90AB1, HSPA1A, KIT, MGAM, MMP12, MMP9, PPARA, PPARG, PRKCB, PRKCD, PRKCE, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SRC, TERT, TNKS, TNKS2, TRPV1, XDH |
4.25913 |
|
[BP] GO:1901564 |
organonitrogen compound metabolic process
|
ACHE, AKR1B1, ALPL, AOX1, APP, AR, AURKB, AXL, BACE1, BCL2, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, CYP1A1, CYP1A2, CYP2D6, DAO, DUSP3, DYRK1A, EGFR, ERBB2, ESR1, F3, FLT3, FUCA1, FUT7, GBA, GBA2, GLO1, HIF1A, HSP90AA1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIM1, POLB, PPARA, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TYR, XDH |
4.24367 |
|
[BP] GO:0072503 |
cellular divalent inorganic cation homeostasis
|
APP, BCL2, CACNA1C, CHRNA7, EDNRA, ESR1, GPR35, GRM1, GRM5, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 |
4.24273 |
|
[BP] GO:0007346 |
regulation of mitotic cell cycle
|
APEX1, APP, AURKB, BCL2, CDC25B, CDK6, CYP1A1, DUSP3, EGFR, HSP90AA1, HSPA1A, INSR, PIM1, PRKCA, SMAD3, TERT, TNKS, TOP2A |
4.22162 |
|
[BP] GO:0050878 |
regulation of body fluid levels
|
ADORA1, AKR1B1, ALOX12, CHRM1, CHRM3, F3, GBA, HIF1A, MET, PRKCA, PRKCD, PRKCE, SLC22A2, XDH |
4.21956 |
|
[BP] GO:0009410 |
None
|
CNR1, CNR2, EGFR, GBA, HSP90AB1, NR3C1, PPARG, PRKCE, PRKCG |
4.21261 |
|
[BP] GO:0006979 |
response to oxidative stress
|
AKR1B1, APEX1, APP, AXL, BCL2, CYP1B1, EGFR, HSPA1A, MMP9, PRKCD, PTGS1, PTGS2, SRC |
4.20746 |
|
[BP] GO:0034614 |
cellular response to reactive oxygen species
|
AKR1B1, APEX1, AXL, CYP1B1, EGFR, MMP9, PRKCD, SRC |
4.2037 |
|
[BP] GO:0015893 |
None
|
ABCB1, CA2, CHRM5, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2 |
4.16699 |
|
[BP] GO:0090087 |
None
|
ACHE, ADORA1, APP, CA2, CACNA1C, CHRM1, CNR1, EGFR, ERBB2, HCAR2, HIF1A, HSP90AB1, MMP12, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC |
4.15514 |
|
[BP] GO:0007268 |
None
|
CHRM1, CHRM2, CHRM3, CHRM5, CHRNA3, GRIA2, GRIK5, GRM1, GRM3, GRM5, PRKCG, SLC1A1 |
4.15514 |
|
[BP] GO:0098916 |
None
|
CHRM1, CHRM2, CHRM3, CHRM5, CHRNA3, GRIA2, GRIK5, GRM1, GRM3, GRM5, PRKCG, SLC1A1 |
4.15514 |
|
[BP] GO:0006082 |
organic acid metabolic process
|
ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DAO, FABP3, GBA2, GLO1, HIF1A, PIM1, PPARA, PPARG, PTGS1, PTGS2, TBXAS1, TYR |
4.15514 |
|
[BP] GO:0015872 |
None
|
CHRM5, SLC22A1, SLC22A2, SLC22A3 |
4.14666 |
|
[BP] GO:0030155 |
regulation of cell adhesion
|
ALOX12, ALOX15, BCL2, CDK6, CYP1B1, DUSP3, ERBB2, KDR, NUAK1, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, SMAD3, SRC, TEK |
4.14381 |
|
[BP] GO:0007271 |
None
|
CHRM1, CHRM2, CHRM3, CHRM5, CHRNA3 |
4.13709 |
|
[BP] GO:0051972 |
regulation of telomerase activity
|
AURKB, HSP90AA1, HSP90AB1, PPARG, SRC, TNKS |
4.1221 |
|
[BP] GO:0018107 |
peptidyl-threonine phosphorylation
|
BCL2, CSNK2A1, DYRK1A, PRKCA, PRKCB, PRKCD, TNKS |
4.09148 |
|
[BP] GO:0032847 |
regulation of cellular pH reduction
|
BCL2, CA2, CA7 |
4.06801 |
|
[BP] GO:1901615 |
organic hydroxy compound metabolic process
|
AKR1B1, AKR1B10, ALOX12, ALOX15, APP, BCL2, CYP19A1, CYP1A1, CYP1B1, DAO, GBA, GBA2, HIF1A, TYR |
4.06502 |
|
[BP] GO:0051246 |
regulation of protein metabolic process
|
ADORA1, ALOX15, APP, AR, BCL2, CDC25B, CHRNA3, CHRNA7, CSNK2A1, DNMT1, DUSP3, DYRK1A, EGFR, ERBB2, ESR1, F3, FABP4, FLT3, GBA, GRM1, GRM5, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, KIT, MMP9, NUAK1, PIK3CA, PIK3CB, PPARG, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH |
4.04158 |
|
[BP] GO:0055065 |
metal ion homeostasis
|
APP, BCL2, CACNA1C, CHRNA7, EDNRA, EGFR, ESR1, GPR35, GRM1, GRM5, HIF1A, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 |
4.03376 |
|
[BP] GO:0031960 |
response to corticosteroid
|
ALPL, BCL2, EGFR, FLT3, GBA, HSD11B2, NR3C1, PTGS2, SRC |
4.02343 |
|
[BP] GO:0003018 |
None
|
ADORA1, ADRB1, CHRM1, CHRM3, EDNRA, EGFR, PTGS2, SRC, TEK |
4.02343 |
|
[BP] GO:0010638 |
positive regulation of organelle organization
|
ALOX15, AURKB, BCL2, DNMT1, GBA, HIF1A, HSPA1A, INSR, KDR, MET, MMP9, PRKCE, SMAD3, SRC, TEK, TNKS, TNKS2 |
4.00871 |
|
[BP] GO:1901655 |
None
|
AKR1B1, AR, EGFR, NR3C1, PPARG, PRKCE, SRC |
3.99344 |
|
[BP] GO:0050994 |
None
|
ADORA1, CNR1, HCAR2, PPARA, PRKCD, PRKCE |
3.98265 |
|
[BP] GO:0006875 |
cellular metal ion homeostasis
|
APP, BCL2, CACNA1C, CHRNA7, EDNRA, ESR1, GPR35, GRM1, GRM5, HIF1A, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 |
3.9821 |
|
[BP] GO:1903426 |
None
|
EGFR, HSP90AA1, HSP90AB1, INSR, PTGS2, SMAD3, TRPV1 |
3.96274 |
|
[BP] GO:0008610 |
lipid biosynthetic process
|
ACHE, AKR1B1, ALOX12, ALOX15, CSNK2A1, CYP19A1, CYP1A1, GBA, HSD11B1, HSD11B2, HSD17B1, HSD17B2, PIK3CA, PIK3CB, PTGS1, PTGS2 |
3.96274 |
|
[BP] GO:0048871 |
multicellular organismal homeostasis
|
ADORA1, ADRB1, AKR1B1, ALOX12, GBA, MET, PIK3CA, TRPV1 |
3.9479 |
|
[BP] GO:0043393 |
regulation of protein binding
|
APP, AURKB, BCL2, HSP90AB1, MET, MMP9, PPARA, PRKCD, SRC, TERT |
3.93463 |
|
[BP] GO:1901699 |
cellular response to nitrogen compound
|
AKR1B1, APEX1, APP, DNMT1, EGFR, GRM5, IGF1R, INSR, MMP2, PPARG, PRKCD, PTGS2, SRC, TRPV1 |
3.91781 |
|
[BP] GO:0007216 |
None
|
GRM1, GRM3, GRM5, GRM8 |
3.87877 |
|
[BP] GO:0045787 |
positive regulation of cell cycle
|
APEX1, APP, AURKB, CDC25B, CYP1A1, DUSP3, EGFR, HSP90AB1, INSR, PRKCA, PRKCE, SRC, TERT |
3.87399 |
|
[BP] GO:0050806 |
positive regulation of synaptic transmission
|
ADORA1, APP, CA2, CA7, CHRNA7, EGFR, PRKCE, PTGS2 |
3.87399 |
|
[BP] GO:0018210 |
peptidyl-threonine modification
|
BCL2, CSNK2A1, DYRK1A, PRKCA, PRKCB, PRKCD, TNKS |
3.86943 |
|
[BP] GO:0032147 |
activation of protein kinase activity
|
ADORA1, CHRNA3, CHRNA7, EGFR, GRM1, INSR, KIT, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC |
3.86612 |
|
[BP] GO:0051094 |
positive regulation of developmental process
|
ALOX12, APP, AR, AXL, BCL2, CA2, CHRNA7, CNR1, CYP1B1, ESRRB, F3, HIF1A, HSP90AB1, INSR, KDR, KIT, PIM1, PPARG, PRKCA, PRKCB, PTGS2, SMAD3, SRC, TEK, TERT |
3.85692 |
|
[BP] GO:0032768 |
None
|
CNR1, CNR2, EGFR, HIF1A, HSP90AA1, TERT |
3.85692 |
|
[BP] GO:0022414 |
reproductive process
|
AKR1B1, ALPL, APP, AR, AXL, BCL2, CDC25B, CNR1, CYP19A1, CYP1A1, EGFR, ESR1, ESRRB, HIF1A, HSD11B2, HSD17B2, HSP90AB1, INSR, KIT, MMP2, MMP9, PGR, PPARG, PTGS2, SRC, TOP2A |
3.81792 |
|
[BP] GO:0009895 |
negative regulation of catabolic process
|
ADORA1, BCL2, CNR1, EGFR, HCAR2, HSP90AB1, MET, PIK3CA, PPARA, PRKCG, SMAD3 |
3.81792 |
|
[BP] GO:0009968 |
negative regulation of signal transduction
|
AR, BCL2, DUSP3, DYRK1A, EGFR, ERBB2, ESR1, ESR2, GBA, HIF1A, HSPA1A, IGF1R, MET, MMP12, MMP9, PPARG, PRKCB, PRKCD, PTGS2, PTPN1, SMAD3, SRC, TERT, XDH |
3.81584 |
|
[BP] GO:0043406 |
positive regulation of MAP kinase activity
|
ADORA1, CHRNA7, EGFR, ERBB2, FLT3, GRM1, INSR, KIT, PIK3CB, PTPN1, SRC |
3.80432 |
|
[BP] GO:0010632 |
regulation of epithelial cell migration
|
HIF1A, KDR, MET, MMP9, PPARG, PRKCA, PRKCE, PTGS2, SRC, TEK |
3.76775 |
|
[BP] GO:0051937 |
None
|
CHRM5, SLC22A1, SLC22A2, SLC22A3 |
3.76157 |
|
[BP] GO:0032880 |
regulation of protein localization
|
ACHE, APP, AR, BCL2, CACNA1C, CHRM1, CNR1, CSNK2A1, EGFR, ERBB2, HCAR2, HIF1A, HSP90AB1, MMP12, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TERT |
3.7576 |
|
[BP] GO:0048608 |
reproductive structure development
|
AR, AXL, BCL2, CYP19A1, ESR1, HSD17B2, HSP90AB1, INSR, KIT, PPARG, SRC |
3.71725 |
|
[BP] GO:0040008 |
regulation of growth
|
ADRB1, ALOX12, APP, AR, BCL2, CSNK2A1, EGFR, ERBB2, ESR2, HIF1A, HSPA1A, INSR, PIK3CA, PIM1, PPARG, SMAD3, TNKS2 |
3.69581 |
|
[BP] GO:1904951 |
positive regulation of establishment of protein localization
|
ACHE, APP, BCL2, CHRM1, EGFR, ERBB2, HCAR2, HIF1A, HSP90AB1, MMP12, PRKCD, PRKCE, PTGS2, SMAD3, SRC |
3.69581 |
|
[BP] GO:1902532 |
negative regulation of intracellular signal transduction
|
BCL2, DUSP3, DYRK1A, ESR1, GBA, HIF1A, HSPA1A, IGF1R, MET, MMP9, PRKCD, PTGS2, PTPN1, SRC, XDH |
3.67651 |
|
[BP] GO:0046903 |
None
|
ALOX5, APP, AXL, CA2, CA9, CHRM1, CHRM3, CHRM5, FUCA1, GAA, HIF1A, HSP90AA1, HSP90AB1, HSPA1A, KIT, MGAM, MMP9, PRKCD, SLC1A1, SLC22A2, TRPV1, XDH |
3.66549 |
|
[BP] GO:1900182 |
positive regulation of protein localization to nucleus
|
APP, EGFR, HSP90AB1, PRKCD, PTGS2, SMAD3, SRC, TERT |
3.66453 |
|
[BP] GO:0070372 |
regulation of ERK1 and ERK2 cascade
|
ALOX15, APP, CHRNA7, DUSP3, EGFR, ERBB2, KDR, PRKCA, PTPN1, SRC, TEK |
3.66386 |
|
[BP] GO:0010557 |
positive regulation of macromolecule biosynthetic process
|
APP, AR, AURKB, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, GBA, HIF1A, HSP90AA1, HSP90AB1, IGF1R, INSR, KDR, MET, MMP12, NR3C1, PGR, PPARA, PPARG, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TOP2A |
3.65582 |
|
[BP] GO:0000302 |
response to reactive oxygen species
|
AKR1B1, APEX1, AXL, BCL2, CYP1B1, EGFR, MMP9, PRKCD, SRC |
3.65582 |
|
[BP] GO:0007213 |
None
|
CHRM1, CHRM2, CHRM3, CHRM5 |
3.65582 |
|
[BP] GO:0019372 |
lipoxygenase pathway
|
ALOX12, ALOX15, ALOX5, PTGS2 |
3.65582 |
|
[BP] GO:0050679 |
None
|
AR, EGFR, ERBB2, F3, HIF1A, KDR, MMP12, PRKCA, TEK |
3.63958 |
|
[BP] GO:0042446 |
hormone biosynthetic process
|
AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 |
3.61787 |
|
[BP] GO:0043434 |
None
|
APEX1, FABP3, HSD11B2, INSR, PPARA, PPARG, PRKCD, PTGS2, SRC, TEK, TRPV1 |
3.61356 |
|
[BP] GO:1901214 |
regulation of neuron death
|
AXL, BCL2, CHRNA7, GBA, GRIK5, HIF1A, HSP90AB1, PIK3CA, PPARA, PRKCG, TERT |
3.61356 |
|
[BP] GO:0009056 |
catabolic process
|
ACHE, ADORA1, AKR1B10, AOX1, AURKB, BACE1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, DAO, FABP3, FABP4, FUCA1, FUT7, GAA, GBA, GBA2, HSP90AA1, HSPA1A, MGAM, MMP1, MMP12, MMP2, MMP9, PIK3CB, SRC, XDH |
3.61288 |
|
[BP] GO:0050877 |
None
|
ADORA1, APP, CHRM1, CHRM5, CHRNA7, CNR1, CNR2, CYP1B1, EGFR, GAA, GRM1, GRM5, GRM8, HIF1A, INSR, KIT, PRKCG, PTGS2, TRPV1, TYR |
3.60591 |
|
[BP] GO:2001243 |
negative regulation of intrinsic apoptotic signaling pathway
|
BCL2, HIF1A, HSPA1A, MMP9, PTGS2, PTPN1, SRC |
3.58588 |
|
[BP] GO:0090257 |
None
|
ADORA1, CACNA1C, CHRM1, CHRM2, CHRM3, CHRNA3, KIT, PRKCA, PTGS2, SMAD3 |
3.57301 |
|
[BP] GO:0009611 |
response to wounding
|
ACHE, ADORA3, ALOX15, BCL2, CYP1A1, EGFR, ERBB2, PPARA, SMAD3 |
3.57239 |
|
[BP] GO:0002009 |
morphogenesis of an epithelium
|
AR, BCL2, CA2, CA9, EDNRA, EGFR, ESR1, HIF1A, MET, SMAD3, SRC |
3.56513 |
|
[BP] GO:0070201 |
None
|
ACHE, APP, BCL2, CACNA1C, CHRM1, CNR1, EGFR, ERBB2, HCAR2, HIF1A, HSP90AB1, MMP12, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC |
3.54514 |
|
[BP] GO:0050730 |
None
|
ADORA1, APP, EGFR, FLT3, GRM5, KIT, PRKCD, PRKCE, PTPN1, SRC |
3.52813 |
|
[BP] GO:1903522 |
None
|
ADORA1, ADORA3, ADRB1, CACNA1C, CHRM1, CHRM2, CHRM3, EGFR, GAA, PTGS2, SLC1A1 |
3.52564 |
|
[BP] GO:0032870 |
cellular response to hormone stimulus
|
APEX1, AR, EGFR, ESR1, FLT3, INSR, KIT, NR3C1, PPARG, PRKCD, PRKCE, SRC |
3.52158 |
|
[BP] GO:0046456 |
icosanoid biosynthetic process
|
ALOX12, ALOX15, ALOX5, PTGS1, PTGS2 |
3.5152 |
|
[BP] GO:2000573 |
positive regulation of DNA biosynthetic process
|
AURKB, HSP90AA1, HSP90AB1, SRC, TNKS, TNKS2 |
3.5152 |
|
[BP] GO:0043065 |
positive regulation of apoptotic process
|
BCL2, CNR1, CYP1B1, F3, GRIK5, HCAR2, MMP9, PIK3CB, PPARG, PRKCD, PTGS2, SMAD3, SRC, TOP2A, TRPV1, XDH |
3.50216 |
|
[BP] GO:0043269 |
regulation of ion transport
|
ABCB1, ADORA1, APP, BCL2, CA2, CA7, CACNA1C, CHRM1, CHRNA3, CNR1, GPR35, GRM5, MMP9, PRKCD, PRKCE, PTGS2 |
3.49422 |
|
[BP] GO:0051384 |
response to glucocorticoid
|
ALPL, BCL2, EGFR, FLT3, GBA, HSD11B2, NR3C1, PTGS2 |
3.48086 |
|
[BP] GO:0007611 |
None
|
APP, CHRNA7, CNR1, EGFR, GRM5, HIF1A, INSR, KIT, PRKCG, PTGS2 |
3.47074 |
|
[BP] GO:2001300 |
lipoxin metabolic process
|
ALOX12, ALOX15, ALOX5 |
3.4608 |
|
[BP] GO:0043068 |
positive regulation of programmed cell death
|
BCL2, CNR1, CYP1B1, F3, GRIK5, HCAR2, MMP9, PIK3CB, PPARG, PRKCD, PTGS2, SMAD3, SRC, TOP2A, TRPV1, XDH |
3.45477 |
|
[BP] GO:1901215 |
negative regulation of neuron death
|
AXL, BCL2, GBA, HIF1A, HSP90AB1, PIK3CA, PPARA, PRKCG, TERT |
3.45372 |
|
[BP] GO:0051726 |
regulation of cell cycle
|
APEX1, APP, AURKB, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, DUSP3, EGFR, HSP90AA1, HSP90AB1, HSPA1A, INSR, PIM1, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TERT, TNKS, TOP2A |
3.45176 |
|
[BP] GO:0045321 |
leukocyte activation
|
ALOX5, AXL, BCL2, FLT3, FUCA1, FUT7, GAA, HSP90AA1, HSP90AB1, HSPA1A, KIT, MGAM, MMP9, PRKCB, PRKCD, PRKCE, RORC, SMAD3, TRPV1 |
3.43547 |
|
[BP] GO:0071902 |
positive regulation of protein serine/threonine kinase activity
|
ADORA1, CHRNA7, EGFR, ERBB2, FLT3, GRM1, HSP90AB1, INSR, KIT, PIK3CB, PTPN1, SRC |
3.4346 |
|
[BP] GO:0035556 |
intracellular signal transduction
|
ADRB1, AKR1B1, AXL, BCL2, CACNA1C, CYP1B1, DNMT1, EGFR, ERBB2, GRM5, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, POLB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SRC, TEK |
3.43004 |
|
[BP] GO:0010810 |
regulation of cell-substrate adhesion
|
ALOX15, BCL2, CDK6, KDR, PIK3CB, PRKCE, SMAD3, SRC, TEK |
3.42323 |
|
[BP] GO:0051222 |
positive regulation of protein transport
|
ACHE, APP, CHRM1, EGFR, ERBB2, HCAR2, HIF1A, HSP90AB1, MMP12, PRKCD, PRKCE, PTGS2, SMAD3, SRC |
3.41 |
|
[BP] GO:0010605 |
negative regulation of macromolecule metabolic process
|
APEX1, APP, AR, AURKB, CHRNA7, CSNK2A1, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, FABP4, GBA, HIF1A, HSP90AB1, HSPA1A, IGF1R, KDR, MMP12, MMP9, NR3C1, PGR, PPARA, PPARG, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TRPV1, XDH |
3.39794 |
|
[BP] GO:0045931 |
positive regulation of mitotic cell cycle
|
APEX1, APP, CDC25B, CYP1A1, DUSP3, INSR, PRKCA, TERT |
3.38493 |
|
[BP] GO:0001952 |
regulation of cell-matrix adhesion
|
BCL2, CDK6, KDR, PIK3CB, SMAD3, SRC, TEK |
3.38473 |
|
[BP] GO:0045913 |
None
|
ESRRB, HIF1A, INSR, PPARA, PRKCE, SRC |
3.38322 |
|
[BP] GO:0048731 |
system development
|
ACHE, ADORA1, ALPL, CACNA1C, CHRM1, CHRM2, CHRM3, CHRNA3, DYRK1A, EDNRA, ERBB2, HIF1A, MMP9, PIK3CA, SMAD3, SRC, TEK |
3.33548 |
|
[BP] GO:2000278 |
regulation of DNA biosynthetic process
|
AURKB, HSP90AA1, HSP90AB1, PPARG, SRC, TNKS, TNKS2 |
3.33548 |
|
[BP] GO:0034599 |
cellular response to oxidative stress
|
AKR1B1, APEX1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, PRKCD, SRC |
3.32608 |
|
[BP] GO:0022603 |
regulation of anatomical structure morphogenesis
|
ALOX12, AR, BCL2, CHRNA3, CHRNA7, CYP1B1, ERBB2, ESR1, F3, HIF1A, KDR, KIT, PIM1, PPARG, PRKCA, PRKCB, PTGS2, SRC, TEK, TERT, XDH |
3.31888 |
|
[BP] GO:0050789 |
regulation of biological process
|
ABCB1, ACHE, ADORA1, ADORA3, ADRB1, AKR1B1, ALOX12, ALOX15, APEX1, APP, AR, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA7, CA9, CACNA1C, CDC25B, CDK6, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA3, CHRNA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DNMT1, DUSP3, DYRK1A, EDNRA, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GAA, GBA, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HIF1A, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH |
3.3132 |
|
[BP] GO:0051223 |
None
|
ACHE, APP, CACNA1C, CHRM1, CNR1, EGFR, ERBB2, HCAR2, HIF1A, HSP90AB1, MMP12, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC |
3.3132 |
|
[BP] GO:0044236 |
multicellular organism metabolic process
|
ADRB1, HIF1A, MMP1, MMP12, MMP2, MMP9, TRPV1 |
3.3132 |
|
[BP] GO:0031329 |
regulation of cellular catabolic process
|
APEX1, BCL2, CNR1, ESRRB, GBA, HIF1A, HSP90AB1, HSPA1A, INSR, KDR, MET, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCG, PTPN1 |
3.30733 |
|
[BP] GO:0007186 |
G-protein coupled receptor signaling pathway
|
ADORA1, ADORA3, ADRB1, APP, CA2, CHRM1, CHRM2, CHRM3, CHRM5, CNR1, CNR2, EDNRA, ESR1, GPR35, GRM1, GRM3, GRM5, GRM8, HCAR2, INSR, PIK3CA, PIK3CB, PPARG, SRC |
3.2751 |
|
[BP] GO:0042542 |
response to hydrogen peroxide
|
AKR1B1, APEX1, AXL, BCL2, CYP1B1, PRKCD, SRC |
3.26364 |
|
[BP] GO:0034754 |
cellular hormone metabolic process
|
AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 |
3.26364 |
|
[BP] GO:0048010 |
vascular endothelial growth factor receptor signaling pathway
|
AXL, HSP90AA1, KDR, PIK3CA, PIK3CB, SRC |
3.25325 |
|
[BP] GO:0009991 |
response to extracellular stimulus
|
ALPL, AXL, BCL2, CNR1, CYP1A1, EGFR, GBA, HSD11B2, PPARG, PTGS2, SRC, TRPV1, TYR |
3.25151 |
|
[BP] GO:0050794 |
regulation of cellular process
|
ACHE, ADORA1, ADORA3, ADRB1, AKR1B1, ALOX12, ALOX15, APEX1, APP, AR, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA7, CA9, CACNA1C, CDC25B, CDK6, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA3, CHRNA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, CYP2D6, DNMT1, DUSP3, DYRK1A, EDNRA, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GBA, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HIF1A, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH |
3.24669 |
|
[BP] GO:0048869 |
cellular developmental process
|
ACHE, ADRB1, ALPL, APP, AR, AXL, BCL2, CBR1, CDC25B, CDK6, CHRNA7, CYP1A1, EDNRA, EGFR, ERBB2, ESR1, ESRRB, FABP4, FLT3, FUT7, GBA2, GLO1, HIF1A, KDR, KIT, MET, MMP2, MMP9, PGR, PPARG, PRKCD, PTGS2, RORC, SMAD3, SRC, TEK, TERT, TOP2A |
3.22124 |
|
[BP] GO:0015844 |
None
|
CHRM5, SLC22A1, SLC22A2, SLC22A3 |
3.21686 |
|
[BP] GO:0060341 |
regulation of cellular localization
|
APP, AR, BCL2, CACNA1C, CHRM1, CHRNA3, CSNK2A1, EGFR, ERBB2, GRIK5, HIF1A, HSP90AB1, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TERT |
3.17508 |
|
[BP] GO:0003013 |
None
|
ADORA1, ADRB1, CHRM1, CHRM3, EDNRA, EGFR, PTGS2, SRC, TEK |
3.15713 |
|
[BP] GO:0048661 |
positive regulation of smooth muscle cell proliferation
|
AKR1B1, EGFR, MMP2, MMP9, PTGS2, TERT |
3.13378 |
|
[BP] GO:0019219 |
regulation of nucleobase-containing compound metabolic process
|
ADORA3, ADRB1, APEX1, APP, AR, AURKB, CA9, CSNK2A1, CYP1B1, DNMT1, DYRK1A, EDNRA, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FABP4, GLO1, GRM3, GRM8, HIF1A, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KIT, MET, MMP12, NR3C1, NR3C2, PGR, PIK3CA, PIM1, POLA1, PPARA, PPARG, PRKCA, PRKCB, PRKCD, PRKCG, PTPN1, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TOP2A, TRPV1 |
3.13378 |
|
[BP] GO:0001503 |
ossification
|
ALOX15, ALPL, BCL2, EGFR, MMP2, MMP9, TEK |
3.1286 |
|
[BP] GO:1901653 |
cellular response to peptide
|
AKR1B1, APEX1, APP, GRM5, IGF1R, INSR, PPARG, PRKCD, SRC |
3.11244 |
|
[BP] GO:2000021 |
regulation of ion homeostasis
|
ADORA1, BCL2, CA2, CA7, CACNA1C, KDR, PRKCE, SRC, TRPV1 |
3.11244 |
|
[BP] GO:0010942 |
positive regulation of cell death
|
BCL2, CNR1, CYP1B1, F3, GRIK5, HCAR2, MMP9, PIK3CB, PPARG, PRKCD, PTGS2, SMAD3, SRC, TOP2A, TRPV1, XDH |
3.09984 |
|
[BP] GO:0046883 |
regulation of hormone secretion
|
ADORA1, CACNA1C, CHRNA3, CNR1, CYP19A1, EGFR, HCAR2, HIF1A, PRKCA, PRKCE |
3.09922 |
|
[BP] GO:0001101 |
response to acid chemical
|
AKR1B1, DNMT1, EGFR, FABP3, HSD17B2, KDR, MMP2, PPARG, PRKCE, PTGS2, SRC |
3.09073 |
|
[BP] GO:0008150 |
biological_process
|
ABCB1, ACHE, ADORA1, ADORA3, ADRB1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AR, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CBR1, CDC25B, CDK6, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA3, CHRNA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DAO, DNMT1, DUSP3, DYRK1A, EDNRA, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUCA1, FUT7, GAA, GBA, GBA2, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HIF1A, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MGAM, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NR3C2, NUAK1, PGR, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SMAD3, SRC, TBXAS1, TEK, TERT, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH |
3.08413 |
|
[BP] GO:0030518 |
intracellular steroid hormone receptor signaling pathway
|
AR, ESR1, ESR2, NR3C1, PGR, SRC |
3.07745 |
|
[BP] GO:0016139 |
None
|
FUCA1, GBA, GBA2 |
3.07489 |
|
[BP] GO:0006937 |
None
|
ADORA1, CACNA1C, CHRM1, CHRM2, CHRM3, CHRNA3, KIT, PTGS2 |
3.07489 |
|
[BP] GO:2001234 |
negative regulation of apoptotic signaling pathway
|
AR, BCL2, HIF1A, HSPA1A, MMP9, PTGS2, PTPN1, SRC, TERT |
3.07122 |
|
[BP] GO:0038083 |
peptidyl-tyrosine autophosphorylation
|
EGFR, IGF1R, INSR, KDR, SRC |
3.05998 |
|
[BP] GO:0060249 |
None
|
AKR1B1, APEX1, BCL2, GAA, HIF1A, HSP90AA1, HSP90AB1, POLA1, SRC, TERT |
3.05185 |
|
[BP] GO:0045934 |
None
|
APEX1, AR, AURKB, DNMT1, DYRK1A, EDNRA, ESR1, ESR2, ESRRA, FABP4, GRM3, GRM8, HSPA1A, MMP12, NR3C1, PPARA, PPARG, PRKCA, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TRPV1 |
3.0352 |
|
[BP] GO:0016042 |
lipid catabolic process
|
ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4, FUCA1, GBA, GBA2 |
3.01378 |
|
[BP] GO:0008210 |
estrogen metabolic process
|
CYP19A1, CYP1B1, HSD17B1, HSD17B2 |
3.00388 |
|
[BP] GO:0097237 |
cellular response to toxic substance
|
AKR1B1, APEX1, AXL, CYP1B1, KDR, PRKCD, PRKCE |
3.00168 |
|
[BP] GO:0035306 |
None
|
ADORA1, GBA, HSP90AB1, PRKCD, SMAD3 |
2.97745 |
|
[BP] GO:0048534 |
hematopoietic or lymphoid organ development
|
BCL2, FLT3, HIF1A, KDR, KIT, POLB, TEK, TYR |
2.97094 |
|
[BP] GO:0044070 |
regulation of anion transport
|
ABCB1, ADORA1, CA2, CA7, GRM5, PRKCD |
2.96706 |
|
[BP] GO:0033273 |
response to vitamin
|
ALPL, CYP1A1, EGFR, PPARG, PTGS2, TYR |
2.96706 |
|
[BP] GO:1903827 |
regulation of cellular protein localization
|
APP, AR, BCL2, CHRM1, CSNK2A1, EGFR, ERBB2, HSP90AB1, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TERT |
2.95279 |
|
[BP] GO:0038127 |
None
|
EGFR, ERBB2, HSP90AA1, PIK3CA, PRKCA, SRC |
2.94198 |
|
[BP] GO:0001816 |
cytokine production
|
APP, FABP4, HIF1A, KIT, PRKCD, PTGS2 |
2.94198 |
|
[BP] GO:1903829 |
positive regulation of cellular protein localization
|
APP, BCL2, CHRM1, EGFR, ERBB2, HSP90AB1, PRKCD, PRKCE, PTGS2, SMAD3, SRC, TERT |
2.94016 |
|
[BP] GO:0097746 |
None
|
ADORA1, ADRB1, CHRM1, CHRM3, EDNRA, EGFR, PTGS2 |
2.92259 |
|
[BP] GO:0035296 |
None
|
ADORA1, ADRB1, CHRM1, CHRM3, EDNRA, EGFR, PTGS2 |
2.92259 |
|
[BP] GO:0032102 |
negative regulation of response to external stimulus
|
ADORA1, ALOX12, CNR2, CYP19A1, GBA, PPARA, PPARG, PRKCD, SMAD3, TEK |
2.90782 |
|
[BP] GO:0031667 |
response to nutrient levels
|
ALPL, BCL2, CNR1, CYP1A1, EGFR, GBA, HSD11B2, PPARG, PTGS2, SRC, TRPV1, TYR |
2.89259 |
|
[BP] GO:0010595 |
positive regulation of endothelial cell migration
|
HIF1A, KDR, MET, PRKCA, PTGS2, TEK |
2.89006 |
|
[BP] GO:2000026 |
regulation of multicellular organismal development
|
ALOX12, APP, AR, AXL, BCL2, CA2, CDK6, CHRNA3, CHRNA7, CNR1, CYP1B1, EGFR, ERBB2, ESR1, ESRRA, F3, HIF1A, INSR, KDR, KIT, PIM1, PPARG, PRKCA, PRKCB, PTGS2, SMAD3, SRC, TEK, TERT, XDH |
2.88861 |
|
[BP] GO:0051241 |
negative regulation of multicellular organismal process
|
ADORA1, ADRB1, ALOX12, APP, AXL, BCL2, CDK6, CHRNA7, EGFR, ERBB2, GBA, GPR35, HIF1A, HSP90AB1, PPARG, PRKCD, PTGS2, SMAD3, TEK, TERT, XDH |
2.88728 |
|
[BP] GO:0046466 |
None
|
CYP1B1, FUCA1, GBA, GBA2 |
2.88104 |
|
[BP] GO:0035235 |
None
|
APP, GRIA2, GRIA4, GRIK5 |
2.88104 |
|
[BP] GO:0010676 |
None
|
ESRRB, INSR, PPARA, PRKCE, SRC |
2.87008 |
|
[BP] GO:0071453 |
cellular response to oxygen levels
|
BCL2, HIF1A, PPARG, PRKCE, PTGS2, SRC, TERT |
2.86417 |
|
[BP] GO:0050776 |
regulation of immune response
|
ALOX15, BCL2, CNR1, DUSP3, ESR1, HSP90AA1, HSP90AB1, HSPA1A, KIT, MMP12, MMP2, PIK3CA, PIK3CB, PPARG, PRKCB, PRKCD, PRKCE, PTPN1, SMAD3, SRC |
2.84806 |
|
[BP] GO:0048660 |
regulation of smooth muscle cell proliferation
|
AKR1B1, EGFR, MMP2, MMP9, PPARG, PTGS2, TERT |
2.84395 |
|
[BP] GO:0007200 |
None
|
CHRM1, CHRM2, CHRM3, CHRM5, ESR1, GRM5 |
2.84103 |
|
[BP] GO:0043412 |
macromolecule modification
|
ALPL, APEX1, APP, AR, AURKB, AXL, BCL2, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, DNMT1, DUSP3, DYRK1A, EGFR, ERBB2, ESR1, FLT3, FUT7, HIF1A, HSP90AA1, IGF1R, INSR, KDR, KIT, MET, NR3C1, NUAK1, PIK3CA, PIM1, POLB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A |
2.83984 |
|
[BP] GO:0098900 |
None
|
CACNA1C, CNR1, CNR2, GBA, GPR35 |
2.83451 |
|
[BP] GO:0060359 |
None
|
CHRNA3, CHRNA7, CNR1, HSP90AB1, PRKCE, PRKCG |
2.82029 |
|
[BP] GO:0051341 |
None
|
CNR1, CNR2, EGFR, HIF1A, HSP90AA1, TERT |
2.82029 |
|
[BP] GO:0038096 |
Fc-gamma receptor signaling pathway involved in phagocytosis
|
HSP90AA1, HSP90AB1, PIK3CA, PIK3CB, PRKCD, PRKCE, SRC |
2.81065 |
|
[BP] GO:0002433 |
immune response-regulating cell surface receptor signaling pathway involved in phagocytosis
|
HSP90AA1, HSP90AB1, PIK3CA, PIK3CB, PRKCD, PRKCE, SRC |
2.81065 |
|
[BP] GO:0007568 |
aging
|
APEX1, AURKB, BCL2, CNR1, CYP1A1, POLB, PRKCD, PTGS2, TERT |
2.8039 |
|
[BP] GO:0097267 |
omega-hydroxylase P450 pathway
|
CYP1A1, CYP1A2, CYP1B1 |
2.79284 |
|
[BP] GO:0044267 |
cellular protein metabolic process
|
ALPL, APP, AR, AURKB, AXL, BACE1, BCL2, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, DUSP3, DYRK1A, EGFR, ERBB2, ESR1, FLT3, FUT7, HIF1A, HSP90AA1, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP2, NUAK1, PIK3CA, PIM1, POLB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A |
2.78703 |
|
[BP] GO:0009889 |
regulation of biosynthetic process
|
ADORA3, ADRB1, APEX1, APP, AR, AURKB, BCL2, CA9, CSNK2A1, CYP1B1, DNMT1, EDNRA, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GBA, GLO1, GRM3, GRM5, GRM8, HIF1A, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, NR3C1, NR3C2, PGR, PIM1, POLA1, PPARA, PPARG, PRKCA, PRKCB, PRKCD, PTGS2, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TOP2A, TRPV1 |
2.77446 |
|
[BP] GO:0050880 |
None
|
ADORA1, ADRB1, CHRM1, CHRM3, EDNRA, EGFR, PTGS2 |
2.77307 |
|
[BP] GO:0002431 |
Fc receptor mediated stimulatory signaling pathway
|
HSP90AA1, HSP90AB1, PIK3CA, PIK3CB, PRKCD, PRKCE, SRC |
2.77307 |
|
[BP] GO:0046320 |
None
|
CNR1, FABP3, PPARA, PPARG |
2.76975 |
|
[BP] GO:0071634 |
None
|
HIF1A, HSP90AB1, PTGS2, SMAD3 |
2.76975 |
|
[BP] GO:0016572 |
histone phosphorylation
|
AURKB, PRKCA, PRKCB, PRKCD |
2.76975 |
|
[BP] GO:1900542 |
None
|
ADRB1, EDNRA, ESRRB, GRM3, GRM8, HIF1A, INSR, PPARA, PRKCA |
2.76835 |
|
[BP] GO:0048729 |
tissue morphogenesis
|
AR, BCL2, CA2, CA9, EDNRA, EGFR, ESR1, HIF1A, MET, SMAD3, SRC |
2.75905 |
|
[BP] GO:0001936 |
None
|
F3, HIF1A, KDR, PPARG, PRKCA, TEK, XDH |
2.75853 |
|
[BP] GO:0035150 |
None
|
ADORA1, ADRB1, CHRM1, CHRM3, EDNRA, EGFR, PTGS2 |
2.75853 |
|
[BP] GO:0043279 |
None
|
CNR1, HSP90AB1, PPARG, PRKCE, PRKCG, TRPV1 |
2.75318 |
|
[BP] GO:0071396 |
cellular response to lipid
|
AR, AXL, CDK6, EGFR, ESR1, FLT3, NR3C1, PPARG, PRKCE, RORC, SRC |
2.75276 |
|
[BP] GO:0038094 |
Fc-gamma receptor signaling pathway
|
HSP90AA1, HSP90AB1, PIK3CA, PIK3CB, PRKCD, PRKCE, SRC |
2.74171 |
|
[BP] GO:0046686 |
response to cadmium ion
|
CYP1A2, EGFR, KIT, MMP9, TERT |
2.74108 |
|
[BP] GO:0010564 |
regulation of cell cycle process
|
APEX1, APP, AURKB, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, EGFR, HSP90AA1, HSP90AB1, HSPA1A, INSR, PRKCE, TERT, TNKS |
2.72503 |
|
[BP] GO:0006636 |
unsaturated fatty acid biosynthetic process
|
ALOX12, ALOX15, PTGS1, PTGS2 |
2.72433 |
|
[BP] GO:0035408 |
None
|
PRKCA, PRKCB |
2.72433 |
|
[BP] GO:0006680 |
None
|
GBA, GBA2 |
2.72433 |
|
[BP] GO:0009115 |
None
|
AOX1, XDH |
2.72433 |
|
[BP] GO:0006286 |
base-excision repair, base-free sugar-phosphate removal
|
APEX1, POLB |
2.72433 |
|
[BP] GO:2001301 |
lipoxin biosynthetic process
|
ALOX12, ALOX15 |
2.72433 |
|
[BP] GO:2001302 |
lipoxin A4 metabolic process
|
ALOX12, ALOX15 |
2.72433 |
|
[BP] GO:2001303 |
lipoxin A4 biosynthetic process
|
ALOX12, ALOX15 |
2.72433 |
|
[BP] GO:0006464 |
cellular protein modification process
|
ALPL, APP, AR, AURKB, AXL, BCL2, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, DUSP3, DYRK1A, EGFR, ERBB2, ESR1, FLT3, FUT7, HIF1A, HSP90AA1, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIM1, POLB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A |
2.71344 |
|
[BP] GO:0036211 |
protein modification process
|
ALPL, APP, AR, AURKB, AXL, BCL2, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, DUSP3, DYRK1A, EGFR, ERBB2, ESR1, FLT3, FUT7, HIF1A, HSP90AA1, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIM1, POLB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A |
2.71344 |
|
[BP] GO:0006140 |
None
|
ADRB1, EDNRA, ESRRB, GRM3, GRM8, HIF1A, INSR, PPARA, PRKCA |
2.69323 |
|
[BP] GO:0002320 |
lymphoid progenitor cell differentiation
|
BCL2, FLT3, KIT |
2.69041 |
|
[BP] GO:0060736 |
prostate gland growth
|
AR, CYP19A1, ESR1 |
2.69041 |
|
[BP] GO:0048732 |
gland development
|
AR, BCL2, CSNK2A1, CYP19A1, EGFR, INSR, PIK3CA, SMAD3, TYR |
2.6831 |
|
[BP] GO:0032409 |
None
|
ABCB1, APP, BCL2, GPR35, GRM5, MMP9, PPARG, PRKCD, PRKCE |
2.6831 |
|
[BP] GO:0043524 |
negative regulation of neuron apoptotic process
|
AXL, BCL2, HIF1A, HSP90AB1, PIK3CA, PRKCG, TERT |
2.68264 |
|
[BP] GO:0035265 |
organ growth
|
AR, BCL2, CYP19A1, ESR1 |
2.68035 |
|
[BP] GO:0043552 |
positive regulation of phosphatidylinositol 3-kinase activity
|
FLT3, KIT, SRC, TEK |
2.68035 |
|
[BP] GO:1904645 |
response to amyloid-beta
|
APP, CHRNA7, GRM5, IGF1R |
2.68035 |
|
[BP] GO:0030258 |
lipid modification
|
ALOX12, CYP1A1, EGFR, ERBB2, KIT, MET, PIK3CA, PIK3CB, PPARG |
2.67301 |
|
[BP] GO:0034502 |
protein localization to chromosome
|
AURKB, ESR1, TERT, TNKS, TNKS2 |
2.65687 |
|
[BP] GO:0031326 |
regulation of cellular biosynthetic process
|
ADORA3, ADRB1, APEX1, APP, AR, AURKB, BCL2, CA9, CSNK2A1, CYP1B1, DNMT1, EDNRA, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GBA, GLO1, GRM3, GRM5, GRM8, HIF1A, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KIT, MET, MMP12, NR3C1, NR3C2, PGR, PIM1, POLA1, PPARA, PPARG, PRKCA, PRKCB, PRKCD, PTGS2, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TOP2A, TRPV1 |
2.65687 |
|
[BP] GO:0006954 |
inflammatory response
|
ADORA1, ADORA3, ALOX15, AXL, CNR2, KIT, PIK3CA, PIK3CB, POLB, PTGS1, PTGS2, TRPV1 |
2.65392 |
|
[BP] GO:0071363 |
cellular response to growth factor stimulus
|
APP, EGFR, ERBB2, INSR, KDR, NR3C1, SMAD3, SRC, TRPV1 |
2.64853 |
|
[BP] GO:0090066 |
None
|
ADORA1, ADRB1, ALOX15, CHRM1, CHRM3, EDNRA, EGFR, HSP90AB1, PRKCD, PRKCE, PTGS2 |
2.64235 |
|
[BP] GO:0019538 |
protein metabolic process
|
ACHE, ALPL, APP, AR, AURKB, AXL, BACE1, BCL2, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, DUSP3, DYRK1A, EGFR, ERBB2, ESR1, F3, FLT3, FUT7, HIF1A, HSP90AA1, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIM1, POLB, PPARA, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A |
2.64225 |
|
[BP] GO:0043271 |
negative regulation of ion transport
|
ADORA1, BCL2, CNR1, GPR35, MMP9, PRKCE, PTGS2 |
2.63155 |
|
[BP] GO:0014065 |
phosphatidylinositol 3-kinase signaling
|
ERBB2, IGF1R, PIK3CA, PIK3CB |
2.62938 |
|
[BP] GO:0042307 |
positive regulation of protein import into nucleus
|
APP, EGFR, HSP90AB1, PRKCD, PTGS2, SMAD3 |
2.60789 |
|
[BP] GO:0042752 |
None
|
ADORA1, PPARA, PPARG, PRKCG, RORC, TOP2A |
2.60789 |
|
[BP] GO:0007584 |
response to nutrient
|
ALPL, CNR1, CYP1A1, EGFR, PPARG, PTGS2, TRPV1, TYR |
2.60583 |
|
[BP] GO:0070301 |
cellular response to hydrogen peroxide
|
AKR1B1, APEX1, AXL, CYP1B1, PRKCD |
2.59566 |
|
[BP] GO:0043523 |
regulation of neuron apoptotic process
|
AXL, BCL2, GRIK5, HIF1A, HSP90AB1, PIK3CA, PRKCG, TERT |
2.59154 |
|
[BP] GO:0046854 |
phosphatidylinositol phosphorylation
|
EGFR, ERBB2, KIT, MET, PIK3CA, PIK3CB |
2.58686 |
|
[BP] GO:0015697 |
None
|
SLC22A1, SLC22A2, SLC22A3 |
2.58686 |
|
[BP] GO:0045759 |
None
|
CNR1, CNR2, GPR35 |
2.58686 |
|
[BP] GO:0032845 |
None
|
ADORA1, BCL2, PRKCE, SRC, TNKS, TNKS2, TRPV1 |
2.58319 |
|
[BP] GO:0033554 |
cellular response to stress
|
AKR1B1, ALOX15, APEX1, AXL, BCL2, CA2, CA9, CYP1B1, EGFR, GBA, HIF1A, HSPA1A, MMP9, NUAK1, POLA1, POLB, PPARG, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TERT, TOP2A, TRPV1 |
2.58076 |
|
[BP] GO:0009896 |
positive regulation of catabolic process
|
CSNK2A1, ESRRB, GBA, HIF1A, HSPA1A, INSR, KDR, PIK3CB, PPARA, PRKCD, PRKCE, PTPN1 |
2.57511 |
|
[BP] GO:1904591 |
positive regulation of protein import
|
APP, EGFR, HSP90AB1, PRKCD, PTGS2, SMAD3 |
2.56822 |
|
[BP] GO:0070374 |
positive regulation of ERK1 and ERK2 cascade
|
ALOX15, APP, CHRNA7, EGFR, KDR, PRKCA, SRC, TEK |
2.55279 |
|
[BP] GO:0014074 |
response to purine-containing compound
|
APEX1, APP, PPARG, PTGS2, TEK, TRPV1, TYR |
2.55042 |
|
[BP] GO:2001233 |
regulation of apoptotic signaling pathway
|
AR, BCL2, HIF1A, HSPA1A, MMP9, PRKCD, PTGS2, PTPN1, SMAD3, SRC, TERT |
2.53797 |
|
[BP] GO:0090218 |
positive regulation of lipid kinase activity
|
FLT3, KIT, SRC, TEK |
2.53797 |
|
[BP] GO:1902893 |
None
|
HIF1A, PPARA, SMAD3, TERT |
2.53797 |
|
[BP] GO:0010907 |
None
|
ESRRB, INSR, PPARA, SRC |
2.53797 |
|
[BP] GO:0106027 |
None
|
APP, CHRNA7, IGF1R, INSR |
2.53797 |
|
[BP] GO:0010863 |
positive regulation of phospholipase C activity
|
EDNRA, EGFR, ESR1, KIT |
2.53797 |
|
[BP] GO:0072593 |
reactive oxygen species metabolic process
|
ALOX12, BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR |
2.52736 |
|
[BP] GO:0001525 |
angiogenesis
|
CYP1B1, HIF1A, KDR, MMP2, PIK3CA, PIK3CB, PRKCA, PTGS2, TEK |
2.52529 |
|
[BP] GO:0071248 |
cellular response to metal ion
|
ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 |
2.52099 |
|
[BP] GO:0002684 |
positive regulation of immune system process
|
APP, AXL, BCL2, CA2, CNR1, HCAR2, HIF1A, HSP90AA1, HSP90AB1, HSPA1A, MMP12, MMP2, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, SRC |
2.51719 |
|
[BP] GO:0035303 |
None
|
ADORA1, CHRM5, GBA, HSP90AB1, NUAK1, PRKCD, SMAD3 |
2.50401 |
|
[BP] GO:0006703 |
estrogen biosynthetic process
|
CYP19A1, HSD17B1, HSD17B2 |
2.49198 |
|
[BP] GO:0032230 |
positive regulation of synaptic transmission, GABAergic
|
CA2, CA7, PRKCE |
2.49198 |
|
[BP] GO:0017144 |
drug metabolic process
|
ACHE, AKR1B1, AKR1B10, AOX1, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, DAO, EGFR, HSPA1A |
2.49198 |
|
[BP] GO:0009266 |
None
|
ADORA1, ADRB1, HSP90AA1, HSPA1A, PPARG, PTGS2, TRPV1 |
2.48856 |
|
[BP] GO:0071456 |
cellular response to hypoxia
|
BCL2, HIF1A, PRKCE, PTGS2, SRC, TERT |
2.48748 |
|
[BP] GO:0045785 |
positive regulation of cell adhesion
|
ALOX12, ALOX15, CDK6, ERBB2, KDR, PIK3CA, PRKCA, PRKCE, SMAD3, SRC, TEK |
2.48748 |
|
[BP] GO:0051090 |
regulation of DNA binding transcription factor activity
|
ADORA3, APP, AR, CYP1B1, ESR1, ESR2, HSPA1A, KIT, PIM1, PPARG, PRKCB |
2.47826 |
|
[BP] GO:0002521 |
leukocyte differentiation
|
AXL, BCL2, FLT3, FUT7, GLO1, KIT, MMP9, PPARG, RORC |
2.46964 |
|
[BP] GO:0010811 |
positive regulation of cell-substrate adhesion
|
ALOX15, CDK6, KDR, PRKCE, SMAD3, TEK |
2.44568 |
|
[BP] GO:0043281 |
regulation of cysteine-type endopeptidase activity involved in apoptotic process
|
CSNK2A1, F3, MMP9, PPARG, PTGS2, SMAD3, SRC, XDH |
2.43589 |
|
[BP] GO:0040014 |
regulation of multicellular organism growth
|
ADRB1, APP, BCL2, PIK3CA, TNKS2 |
2.42844 |
|
[BP] GO:1900076 |
regulation of cellular response to insulin stimulus
|
ESRRA, PRKCB, PRKCD, PTPN1, SRC |
2.42844 |
|
[BP] GO:0006721 |
terpenoid metabolic process
|
AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, EGFR |
2.42652 |
|
[BP] GO:1900274 |
regulation of phospholipase C activity
|
EDNRA, EGFR, ESR1, KIT |
2.4068 |
|
[BP] GO:0051973 |
positive regulation of telomerase activity
|
AURKB, HSP90AA1, HSP90AB1, TNKS |
2.4068 |
|
[BP] GO:0035307 |
None
|
ADORA1, GBA, HSP90AB1, PRKCD |
2.4068 |
|
[BP] GO:0035304 |
regulation of protein dephosphorylation
|
ADORA1, GBA, HSP90AB1, NUAK1, PRKCD |
2.40526 |
|
[BP] GO:0060065 |
uterus development
|
CYP19A1, ESR1, SRC |
2.40526 |
|
[BP] GO:0019377 |
None
|
FUCA1, GBA, GBA2 |
2.40526 |
|
[BP] GO:0010594 |
regulation of endothelial cell migration
|
HIF1A, KDR, MET, PPARG, PRKCA, PTGS2, TEK |
2.39769 |
|
[BP] GO:0051701 |
interaction with host
|
AXL, EGFR, HSPA1A, INSR, MET, SMAD3, SRC |
2.36615 |
|
[BP] GO:2001242 |
regulation of intrinsic apoptotic signaling pathway
|
BCL2, HIF1A, HSPA1A, MMP9, PTGS2, PTPN1, SRC |
2.36615 |
|
[BP] GO:0007190 |
None
|
ADORA3, ADRB1, EDNRA, PRKCA |
2.36615 |
|
[BP] GO:0008285 |
negative regulation of cell proliferation
|
ADORA1, ADORA3, APP, AR, BCL2, CDK6, CYP1B1, ERBB2, FABP3, HSPA1A, PPARG, PTGS2, SMAD3, TERT, XDH |
2.35557 |
|
[BP] GO:0007589 |
None
|
CHRM1, CHRM3, HIF1A, SLC22A2, XDH |
2.35194 |
|
[BP] GO:0036294 |
cellular response to decreased oxygen levels
|
BCL2, HIF1A, PRKCE, PTGS2, SRC, TERT |
2.35194 |
|
[BP] GO:0046834 |
lipid phosphorylation
|
EGFR, ERBB2, KIT, MET, PIK3CA, PIK3CB |
2.35194 |
|
[BP] GO:0046486 |
glycerolipid metabolic process
|
ACHE, ALOX15, CSNK2A1, EGFR, ERBB2, FABP3, FABP4, KIT, MET, PIK3CA, PIK3CB |
2.34423 |
|
[BP] GO:0002683 |
negative regulation of immune system process
|
ADORA1, ALOX15, AXL, CDK6, CNR1, CNR2, CYP19A1, DUSP3, ERBB2, MMP12, PPARG |
2.33435 |
|
[BP] GO:0035239 |
tube morphogenesis
|
BCL2, EDNRA, EGFR, ESR1, HIF1A, MET, SMAD3, SRC |
2.33435 |
|
[BP] GO:0015695 |
None
|
SLC22A1, SLC22A2, SLC22A3, SLC47A1 |
2.33435 |
|
[BP] GO:1900543 |
None
|
EDNRA, GRM3, GRM8, PPARA, PRKCA |
2.33435 |
|
[BP] GO:0034097 |
response to cytokine
|
ALOX15, AXL, BCL2, FABP4, FLT3, GBA, HIF1A, HSP90AB1, PRKCA, PTGS2, SRC, TRPV1 |
2.33435 |
|
[BP] GO:0070198 |
None
|
TERT, TNKS, TNKS2 |
2.33435 |
|
[BP] GO:0099566 |
None
|
GRM1, GRM5 |
2.33435 |
|
[BP] GO:0060748 |
None
|
AR, PGR |
2.33435 |
|
[BP] GO:0098502 |
DNA dephosphorylation
|
APEX1, POLB |
2.33435 |
|
[BP] GO:0000023 |
None
|
GAA, MGAM |
2.33435 |
|
[BP] GO:0046110 |
None
|
AOX1, XDH |
2.33435 |
|
[BP] GO:0023021 |
None
|
GBA, PRKCD |
2.33435 |
|
[BP] GO:0032849 |
positive regulation of cellular pH reduction
|
CA2, CA7 |
2.33435 |
|
[BP] GO:1905144 |
None
|
CHRNA3, CHRNA7 |
2.33435 |
|
[BP] GO:0002520 |
None
|
CACNA1C, SMAD3 |
2.33435 |
|
[BP] GO:1901617 |
organic hydroxy compound biosynthetic process
|
AKR1B1, ALOX12, ALOX15, CYP19A1, DAO, GBA, TYR |
2.32241 |
|
[BP] GO:0045980 |
None
|
EDNRA, GRM3, GRM8, PPARA, PRKCA |
2.31578 |
|
[BP] GO:0032103 |
positive regulation of response to external stimulus
|
CNR1, EGFR, F3, FABP4, KDR, MET, PRKCA, PTGS2, SMAD3 |
2.29306 |
|
[BP] GO:0070848 |
response to growth factor
|
APP, EGFR, ERBB2, INSR, KDR, NR3C1, SMAD3, SRC, TRPV1 |
2.29306 |
|
[BP] GO:0030100 |
regulation of endocytosis
|
ALOX15, APP, AXL, PIK3CB, PPARG, PRKCG, PTPN1, SRC |
2.29257 |
|
[BP] GO:0043627 |
response to estrogen
|
CA2, ESR1, GBA, PPARG, TEK |
2.2899 |
|
[BP] GO:0044089 |
positive regulation of cellular component biogenesis
|
ALOX15, ESR1, HSPA1A, KDR, KIT, MET, MMP1, PRKCA, PRKCE, SMAD3, SRC, TEK |
2.27694 |
|
[BP] GO:1900180 |
regulation of protein localization to nucleus
|
APP, EGFR, HSP90AB1, PRKCD, PTGS2, SMAD3, SRC, TERT |
2.26743 |
|
[BP] GO:0071383 |
None
|
AR, EGFR, FLT3, NR3C1, SRC |
2.26383 |
|
[BP] GO:0045595 |
regulation of cell differentiation
|
APP, AR, AXL, BCL2, CA2, CDK6, CHRNA3, CNR1, EGFR, ERBB2, ESRRA, ESRRB, HIF1A, HSP90AB1, KDR, KIT, PPARA, PPARG, PRKCA, PRKCB, PTGS2, RORC, SMAD3, TERT, TRPV1, XDH |
2.26039 |
|
[BP] GO:2000811 |
negative regulation of anoikis
|
BCL2, PIK3CA, SRC |
2.26039 |
|
[BP] GO:0032075 |
None
|
HSPA1A, PRKCD, PTPN1 |
2.26039 |
|
[BP] GO:0030540 |
female genitalia development
|
AXL, CYP19A1, ESR1 |
2.26039 |
|
[BP] GO:0051131 |
None
|
HSP90AA1, HSP90AB1, HSPA1A |
2.26039 |
|
[BP] GO:0070920 |
None
|
EGFR, ESR1, TERT |
2.26039 |
|
[BP] GO:0048546 |
None
|
BCL2, EGFR, HIF1A |
2.26039 |
|
[BP] GO:0001959 |
None
|
AXL, HIF1A, HSP90AB1, HSPA1A, MMP12, PPARG, PTPN1 |
2.25264 |
|
[BP] GO:0051480 |
regulation of cytosolic calcium ion concentration
|
CACNA1C, EDNRA, ESR1, GPR35, GRM1, GRM5, PRKCE, SMAD3, TRPV1 |
2.23454 |
|
[BP] GO:0002376 |
immune system process
|
ALOX5, APP, AXL, BCL2, CACNA1C, CNR2, FLT3, FUCA1, FUT7, GAA, HIF1A, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, KIT, MGAM, MMP1, MMP9, PIK3CA, PIK3CB, POLB, PPARG, PRKCB, PRKCD, PRKCE, RORC, SMAD3, SRC, TEK, TRPV1 |
2.22931 |
|
[BP] GO:0009268 |
None
|
CA2, GBA, SRC, TRPV1 |
2.22798 |
|
[BP] GO:0033574 |
response to testosterone
|
AR, CA9, CSNK2A1, GBA |
2.22798 |
|
[BP] GO:0022602 |
ovulation cycle process
|
BCL2, ESR1, KIT, PGR, SRC |
2.21959 |
|
[BP] GO:0031100 |
animal organ regeneration
|
AXL, CSNK2A1, EGFR, FLT3, PPARG |
2.21959 |
|
[BP] GO:0009653 |
anatomical structure morphogenesis
|
APP, AR, AXL, BCL2, CA2, CA9, CACNA1C, CHRNA7, CYP1B1, EDNRA, EGFR, ESR1, GAA, GBA, HIF1A, INSR, MET, MMP2, POLB, SMAD3, SRC, TEK |
2.2139 |
|
[BP] GO:0050866 |
negative regulation of cell activation
|
ALOX12, AXL, CNR1, CNR2, DUSP3, ERBB2, PRKCD |
2.21056 |
|
[BP] GO:0042060 |
None
|
ALOX15, EGFR, ERBB2, PPARA, SMAD3 |
2.1947 |
|
[BP] GO:0002252 |
None
|
ALOX5, APP, BCL2, FUCA1, FUT7, GAA, HSP90AA1, HSP90AB1, HSPA1A, KIT, MGAM, MMP9, PIK3CA, PIK3CB, PRKCD, PRKCE, RORC, SRC |
2.1947 |
|
[BP] GO:0051046 |
None
|
ACHE, ADORA1, CACNA1C, CHRNA3, CNR1, CYP19A1, EGFR, GRIK5, HCAR2, HIF1A, MMP12, PRKCA, PRKCE, SRC, TRPV1 |
2.19402 |
|
[BP] GO:0045776 |
None
|
ADORA1, ADRB1, CNR1, PPARA |
2.19171 |
|
[BP] GO:0008631 |
intrinsic apoptotic signaling pathway in response to oxidative stress
|
BCL2, CYP1B1, PRKCD |
2.18964 |
|
[BP] GO:1904355 |
positive regulation of telomere capping
|
AURKB, TNKS, TNKS2 |
2.18964 |
|
[BP] GO:0010675 |
None
|
ESRRB, INSR, PPARA, PRKCE, RORC, SRC |
2.18964 |
|
[BP] GO:0021700 |
developmental maturation
|
APP, AXL, CDC25B, HIF1A, MMP2, PGR, PPARG |
2.18599 |
|
[BP] GO:0071241 |
cellular response to inorganic substance
|
ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 |
2.18599 |
|
[BP] GO:0051345 |
None
|
ADRB1, APP, EDNRA, EGFR, ERBB2, ESR1, F3, HSP90AB1, HSPA1A, KIT, PPARG, PRKCD, PTPN1, SMAD3, XDH |
2.17407 |
|
[BP] GO:0044242 |
None
|
AKR1B10, CYP1B1, FABP3, FABP4, FUCA1, GBA, GBA2 |
2.17176 |
|
[BP] GO:0001961 |
None
|
AXL, HIF1A, HSPA1A, MMP12 |
2.15882 |
|
[BP] GO:0043551 |
regulation of phosphatidylinositol 3-kinase activity
|
FLT3, KIT, SRC, TEK |
2.15882 |
|
[BP] GO:0006109 |
regulation of carbohydrate metabolic process
|
ESRRB, HIF1A, INSR, PPARA, PRKCE, RORC, SRC |
2.15882 |
|
[BP] GO:0060759 |
None
|
AXL, HIF1A, HSP90AB1, HSPA1A, MMP12, PPARG, PTPN1 |
2.1442 |
|
[BP] GO:0070542 |
None
|
FABP3, PPARG, PRKCE, PTGS2, SRC |
2.12811 |
|
[BP] GO:1901570 |
None
|
ALOX12, ALOX15, ALOX5, PTGS1, PTGS2 |
2.12811 |
|
[BP] GO:0051336 |
regulation of hydrolase activity
|
ADRB1, APP, CSNK2A1, EDNRA, EGFR, ERBB2, ESR1, F3, HSP90AB1, HSPA1A, KIT, MMP9, NUAK1, PPARG, PRKCD, PTGS2, PTPN1, SMAD3, SRC, XDH |
2.1252 |
|
[BP] GO:0043536 |
positive regulation of blood vessel endothelial cell migration
|
HIF1A, KDR, PRKCA, PTGS2 |
2.1252 |
|
[BP] GO:0030818 |
None
|
EDNRA, GRM3, GRM8, PRKCA |
2.1252 |
|
[BP] GO:0006720 |
isoprenoid metabolic process
|
AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, EGFR |
2.1252 |
|
[BP] GO:0072488 |
None
|
SLC22A1, SLC22A2, SLC22A3 |
2.1252 |
|
[BP] GO:0007004 |
None
|
HSP90AA1, HSP90AB1, TERT |
2.1252 |
|
[BP] GO:0090330 |
regulation of platelet aggregation
|
ALOX12, PRKCA, PRKCD |
2.1252 |
|
[BP] GO:0045821 |
None
|
ESRRB, HIF1A, INSR |
2.1252 |
|
[BP] GO:0032963 |
collagen metabolic process
|
HIF1A, MMP1, MMP12, MMP2, MMP9 |
2.1087 |
|
[BP] GO:0006694 |
steroid biosynthetic process
|
AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 |
2.10788 |
|
[BP] GO:0016477 |
cell migration
|
AXL, CNR2, CYP1B1, EGFR, FUT7, HIF1A, KDR, KIT, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, PRKCD, SRC, TEK |
2.10615 |
|
[BP] GO:2000116 |
regulation of cysteine-type endopeptidase activity
|
CSNK2A1, F3, MMP9, PPARG, PTGS2, SMAD3, SRC, XDH |
2.10615 |
|
[BP] GO:0001954 |
positive regulation of cell-matrix adhesion
|
CDK6, KDR, SMAD3, TEK |
2.09278 |
|
[BP] GO:0006357 |
None
|
APP, AR, AURKB, CA9, DNMT1, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, GLO1, HIF1A, HSPA1A, KIT, MET, MMP12, NR3C1, PGR, PPARA, PPARG, PRKCB, RORC, SMAD3, TERT, TNKS, TOP2A, TRPV1 |
2.09058 |
|
[BP] GO:2000106 |
regulation of leukocyte apoptotic process
|
AURKB, AXL, HCAR2, HIF1A, PIK3CB |
2.08785 |
|
[BP] GO:0051254 |
None
|
APP, AR, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, HIF1A, HSPA1A, INSR, MET, MMP12, NR3C1, PGR, PPARA, PPARG, RORC, SMAD3, SRC, TERT, TNKS, TOP2A |
2.08296 |
|
[BP] GO:0098908 |
None
|
GBA, GPR35 |
2.08296 |
|
[BP] GO:0015874 |
None
|
SLC22A1, SLC22A2 |
2.08296 |
|
[BP] GO:1901374 |
None
|
SLC22A1, SLC22A2 |
2.08296 |
|
[BP] GO:1905323 |
None
|
HSP90AA1, HSP90AB1 |
2.08296 |
|
[BP] GO:0033031 |
positive regulation of neutrophil apoptotic process
|
HCAR2, PIK3CB |
2.08296 |
|
[BP] GO:0070213 |
None
|
TNKS, TNKS2 |
2.08296 |
|
[BP] GO:0006145 |
None
|
AOX1, XDH |
2.08296 |
|
[BP] GO:0038171 |
None
|
CNR1, CNR2 |
2.08296 |
|
[BP] GO:0018894 |
dibenzo-p-dioxin metabolic process
|
CYP1A1, CYP1A2 |
2.08296 |
|
[BP] GO:0048469 |
cell maturation
|
APP, AXL, CDC25B, HIF1A, PGR, PPARG |
2.08296 |
|
[BP] GO:0051900 |
regulation of mitochondrial depolarization
|
BCL2, KDR, SRC |
2.0693 |
|
[BP] GO:0035162 |
embryonic hemopoiesis
|
HIF1A, KDR, KIT |
2.0693 |
|
[BP] GO:0051197 |
None
|
ESRRB, HIF1A, INSR |
2.0693 |
|
[BP] GO:0030803 |
None
|
EDNRA, GRM3, GRM8, PRKCA |
2.06923 |
|
[BP] GO:0019217 |
None
|
CNR1, FABP3, PPARA, PPARG, PTGS2 |
2.05398 |
|
[BP] GO:1901989 |
None
|
APEX1, APP, CDC25B, CYP1A1, TERT |
2.05398 |
|
[BP] GO:0046683 |
response to organophosphorus
|
APEX1, APP, PTGS2, TEK, TRPV1, TYR |
2.05398 |
|
[BP] GO:0002263 |
None
|
ALOX5, APP, FUCA1, GAA, HSP90AA1, HSP90AB1, HSPA1A, KIT, MGAM, MMP9, PRKCD, PRKCE, RORC |
2.04765 |
|
[BP] GO:0051091 |
positive regulation of DNA binding transcription factor activity
|
APP, AR, ESR1, ESR2, HSPA1A, KIT, PPARG, PRKCB |
2.04005 |
|
[BP] GO:0060760 |
None
|
AXL, HIF1A, HSPA1A, MMP12 |
2.0385 |
|
[BP] GO:1903530 |
regulation of secretion by cell
|
ACHE, ADORA1, CACNA1C, CHRNA3, CNR1, CYP19A1, EGFR, GRIK5, HCAR2, HIF1A, MMP12, PRKCA, PRKCE, SRC |
2.03701 |
|
[BP] GO:0038093 |
Fc receptor signaling pathway
|
HSP90AA1, HSP90AB1, KIT, PIK3CA, PIK3CB, PRKCD, PRKCE, SRC |
2.02976 |
|
[BP] GO:1901575 |
None
|
ACHE, ADORA1, AKR1B10, AOX1, AURKB, BACE1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, DAO, FABP3, FABP4, FUCA1, FUT7, GAA, GBA, GBA2, HSP90AA1, HSPA1A, MGAM, XDH |
2.0196 |
|
[BP] GO:0009605 |
response to external stimulus
|
ADORA1, ALPL, AXL, BCL2, CDK6, CHRM2, CNR1, CNR2, CYP1A1, CYP1A2, EGFR, GBA, HSD11B2, KIT, MMP12, PPARG, PRKCD, PTGS2, SMAD3, SRC, TRPV1, TYR |
2.01295 |
|
[BP] GO:0044259 |
multicellular organismal macromolecule metabolic process
|
HIF1A, MMP1, MMP12, MMP2, MMP9 |
2.0129 |
|
[BP] GO:0001938 |
None
|
F3, HIF1A, KDR, PRKCA, TEK |
2.0129 |
|
[BP] GO:0001892 |
None
|
EGFR, ESRRB, HIF1A |
2.01144 |
|
[BP] GO:0030815 |
None
|
EDNRA, GRM3, GRM8, PRKCA |
2.008 |
|
[BP] GO:0002791 |
None
|
ACHE, ADORA1, CACNA1C, CNR1, EGFR, HCAR2, HIF1A, MMP12, PRKCA, PRKCE, SRC |
2.00777 |
|
[CC] GO:0005886 |
plasma membrane
|
ABCB1, ACHE, ADORA1, ADORA3, ADRB1, ALOX12, ALOX15, ALPL, APP, AR, AXL, BACE1, CA12, CA14, CA2, CA4, CA9, CACNA1C, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA3, CHRNA7, CNR1, CNR2, CSNK2A1, EDNRA, EGFR, ERBB2, ESR1, F3, FLT3, GAA, GBA2, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSP90AA1, IGF1R, INSR, KDR, KIT, MET, MGAM, MMP2, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SMAD3, SRC, TEK, TERT, TRPV1 |
11.4176 |
|
[CC] GO:0098590 |
plasma membrane region
|
ABCB1, ADORA1, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA3, CHRNA7, CNR1, EGFR, ERBB2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSP90AA1, HSP90AB1, INSR, MET, MGAM, PRKCG, PTGS2, SLC1A1, SLC22A1, SRC, TEK, TRPV1 |
10.6866 |
|
[CC] GO:0016020 |
membrane
|
ABCB1, ACHE, ADORA1, ADORA3, ADRB1, ALOX12, ALOX15, ALOX5, ALPL, APP, AR, AXL, BACE1, BCL2, CA12, CA14, CA2, CA4, CA9, CACNA1C, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA3, CHRNA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DAO, EDNRA, EGFR, ERBB2, ESR1, F3, FLT3, FUT7, GAA, GBA, GBA2, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD11B1, HSD11B2, HSD17B2, HSP90AA1, HSP90AB1, IGF1R, INSR, KDR, KIT, MET, MGAM, MMP2, NR3C2, PGR, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SMAD3, SRC, TBXAS1, TEK, TERT, TNKS, TNKS2, TRPV1, TYR |
9.99166 |
|
[CC] GO:0044459 |
plasma membrane part
|
ABCB1, ADORA1, ADORA3, ADRB1, ALOX15, APP, AXL, BACE1, CA2, CA4, CA9, CACNA1C, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA3, CHRNA7, CNR1, CNR2, DUSP3, EDNRA, EGFR, ERBB2, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSP90AA1, HSP90AB1, IGF1R, INSR, KDR, KIT, MET, MGAM, PRKCG, PTGS2, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SRC, TEK, TRPV1 |
8.88653 |
|
[CC] GO:0097060 |
None
|
CHRM1, CHRM2, CHRM3, CHRM5, CHRNA3, CHRNA7, CNR1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, PRKCG, TRPV1 |
7.47601 |
|
[CC] GO:0044456 |
None
|
ACHE, ADORA1, APP, CACNA1C, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA3, CHRNA7, CNR1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, PRKCG, SLC22A2, SRC, TRPV1 |
6.37146 |
|
[CC] GO:0031226 |
intrinsic component of plasma membrane
|
ADORA1, ADORA3, ADRB1, APP, AXL, BACE1, CA4, CHRM1, CHRM2, CHRM3, CHRM5, CNR1, CNR2, EDNRA, F3, FLT3, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, SLC1A1, SLC22A1, SLC22A2, SLC22A3, TEK, TRPV1 |
6.11091 |
|
[CC] GO:0044425 |
membrane part
|
ABCB1, ACHE, ADORA1, ADORA3, ADRB1, ALOX15, ALPL, APP, AXL, BACE1, BCL2, CA12, CA14, CA2, CA4, CA9, CACNA1C, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA3, CHRNA7, CNR1, CNR2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DUSP3, EDNRA, EGFR, ERBB2, ESR1, F3, FLT3, FUT7, GBA2, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD11B1, HSD11B2, HSD17B2, HSP90AA1, HSP90AB1, IGF1R, INSR, KDR, KIT, MET, MGAM, MPEG1, NR3C2, PIK3CA, PIK3CB, PRKCG, PTGS1, PTGS2, PTPN1, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SRC, TBXAS1, TEK, TRPV1, TYR |
5.96337 |
|
[CC] GO:0005887 |
integral component of plasma membrane
|
ADORA1, ADORA3, ADRB1, APP, AXL, BACE1, CHRM1, CHRM2, CHRM3, CHRM5, CNR1, CNR2, EDNRA, FLT3, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, SLC1A1, SLC22A1, SLC22A2, SLC22A3, TEK, TRPV1 |
5.47226 |
|
[CC] GO:0043235 |
receptor complex
|
APP, CHRNA3, CHRNA7, EGFR, ERBB2, GRIA2, GRIA4, GRIK5, GRM1, HSP90AB1, IGF1R, INSR, NR3C2, SMAD3 |
5.22117 |
|
[CC] GO:0045211 |
None
|
CHRM1, CHRM2, CHRM3, CHRM5, CHRNA3, CHRNA7, GRIA2, GRIA4, GRIK5, GRM3, TRPV1 |
4.64463 |
|
[CC] GO:0016323 |
basolateral plasma membrane
|
ADORA1, CA2, CA4, CA9, CHRM3, EGFR, ERBB2, HSP90AB1, SLC22A1, TEK |
4.26871 |
|
[CC] GO:0014069 |
None
|
ADORA1, CACNA1C, CHRM1, CHRNA3, GRIK5, GRM1, GRM3, GRM5, PRKCG, SRC |
4.05385 |
|
[CC] GO:0099572 |
None
|
ADORA1, CACNA1C, CHRM1, CHRNA3, GRIK5, GRM1, GRM3, GRM5, PRKCG, SRC |
4.05385 |
|
[CC] GO:0044444 |
cytoplasmic part
|
ACHE, ADORA1, ADRB1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, APEX1, APP, AR, AURKB, BACE1, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA7, CACNA1C, CBR1, CDC25B, CDK6, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DAO, DUSP3, EGFR, ERBB2, ESR1, ESR2, FABP3, FABP4, FLT3, FUCA1, FUT7, GAA, GBA, GBA2, GLO1, GRIA2, GRIA4, GRIK5, HIF1A, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, INSR, KDR, KIT, MGAM, MMP2, MMP9, NQO2, NR3C1, NR3C2, PGR, PIK3CA, PIK3CB, PIM1, POLA1, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, SMAD3, SRC, TBXAS1, TERT, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH |
3.9821 |
|
[CC] GO:0043005 |
None
|
ADORA1, APP, BACE1, CA2, CHRM1, CHRM2, CHRM3, CHRNA3, CNR1, CNR2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, PRKCG, PTGS2, SRC |
3.75182 |
|
[CC] GO:0097458 |
None
|
ADORA1, APP, BACE1, CA2, CACNA1C, CHRM1, CHRM2, CHRM3, CHRNA3, CNR1, CNR2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HIF1A, INSR, PRKCG, PTGS1, PTGS2, SLC22A2, SRC, TRPV1 |
3.60374 |
|
[CC] GO:0044464 |
cell part
|
ABCB1, ACHE, ADORA1, ADORA3, ADRB1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AR, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA7, CA9, CACNA1C, CBR1, CDC25B, CDK6, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA3, CHRNA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DAO, DNMT1, DUSP3, DYRK1A, EDNRA, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUCA1, FUT7, GAA, GBA, GBA2, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HIF1A, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MGAM, MMP12, MMP2, MMP9, NQO2, NR3C1, NR3C2, NUAK1, PGR, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SMAD3, SRC, TBXAS1, TEK, TERT, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH |
3.5972 |
|
[CC] GO:0042734 |
None
|
CNR1, GRIK5, GRM1, GRM3, GRM5, GRM8 |
3.58588 |
|
[CC] GO:0045121 |
membrane raft
|
APP, BACE1, CHRNA3, CHRNA7, CNR1, EGFR, INSR, KDR, PTGS2, SRC, TEK |
3.4292 |
|
[CC] GO:0043226 |
organelle
|
ABCB1, ACHE, ADORA1, ADRB1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALPL, AOX1, APEX1, APP, AR, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA6, CA9, CACNA1C, CBR1, CDK6, CHRM1, CHRNA3, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DAO, DNMT1, DUSP3, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUCA1, FUT7, GAA, GBA, GBA2, GLO1, GRIA4, GRIK5, GRM1, GRM3, GRM5, HIF1A, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, KIT, MGAM, MMP12, MMP2, MMP9, NQO2, NR3C1, NUAK1, PIK3CB, PIM1, POLA1, POLB, PPARA, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SLC22A2, SLC47A1, SMAD3, SRC, TERT, TNKS, TNKS2, TOP2A, TYR, XDH |
3.4111 |
|
[CC] GO:0098857 |
membrane microdomain
|
APP, BACE1, CHRNA3, CHRNA7, CNR1, EGFR, INSR, KDR, PTGS2, SRC, TEK |
3.40532 |
|
[CC] GO:0048471 |
perinuclear region of cytoplasm
|
ACHE, AKR1B1, APEX1, APP, CA4, EGFR, ERBB2, HSPA1A, PPARG, PRKCA, PRKCD, PRKCE, PRKCG, SRC, TNKS2, TYR |
3.20825 |
|
[CC] GO:0043227 |
membrane-bounded organelle
|
ABCB1, ACHE, ADORA1, ADRB1, AKR1B1, AKR1B10, ALOX12, ALPL, AOX1, APEX1, APP, AR, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA6, CBR1, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DAO, DNMT1, DUSP3, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUCA1, FUT7, GAA, GBA, GBA2, GLO1, GRIA4, GRIK5, GRM1, GRM5, HIF1A, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, KIT, MGAM, MMP12, MMP2, MMP9, NQO2, NR3C1, NUAK1, PIK3CB, PIM1, POLA1, POLB, PPARA, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SLC22A2, SLC47A1, SMAD3, SRC, TERT, TNKS, TNKS2, TOP2A, TYR, XDH |
3.19619 |
|
[CC] GO:0120025 |
None
|
ADORA1, AKR1B1, APP, BACE1, CA2, CDK6, CHRM1, CHRM2, CHRM3, CHRNA3, CNR1, CNR2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, HIF1A, PIK3CA, PRKCG, PTGS2, SRC, TEK |
3.17777 |
|
[CC] GO:0042995 |
cell projection
|
ADORA1, AKR1B1, APP, BACE1, CA2, CDK6, CHRM1, CHRM2, CHRM3, CHRNA3, CNR1, CNR2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, HIF1A, PIK3CA, PRKCG, PTGS2, SRC, TEK |
2.83153 |
|
[CC] GO:0098589 |
membrane region
|
APP, BACE1, CHRNA3, CHRNA7, CNR1, EGFR, INSR, KDR, PTGS2, SRC, TEK |
2.76853 |
|
[CC] GO:0044463 |
None
|
ADORA1, AKR1B1, APP, CA4, CA9, CHRM1, CHRM2, CHRM3, CNR1, GRIA2, GRIA4, GRIK5, GRM3, HIF1A, HSP90AA1, HSP90AB1, INSR, PTGS1, SRC, TRPV1 |
2.70449 |
|
[CC] GO:0120038 |
None
|
ADORA1, AKR1B1, APP, CA4, CA9, CHRM1, CHRM2, CHRM3, CNR1, GRIA2, GRIA4, GRIK5, GRM3, HIF1A, HSP90AA1, HSP90AB1, INSR, PTGS1, SRC, TRPV1 |
2.70449 |
|
[CC] GO:0005789 |
endoplasmic reticulum membrane
|
BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, EGFR, GBA2, GRIA2, HSD11B1, HSD11B2, HSD17B2, NR3C2, PTGS1, PTGS2, TBXAS1 |
2.53458 |
|
[CC] GO:0044432 |
endoplasmic reticulum part
|
APP, BACE1, BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, EGFR, FLT3, GBA2, GRIA2, HSD11B1, HSD11B2, HSD17B2, NR3C2, PTGS1, PTGS2, PTPN1, TBXAS1 |
2.46091 |
|
[CC] GO:0030054 |
cell junction
|
ACHE, AKR1B1, APP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA3, CHRNA7, EGFR, GRIA2, GRIA4, GRIK5, HCAR2, HSPA1A, KDR, KIT, PRKCD, PRKCG, TEK, TRPV1 |
2.42844 |
|
[CC] GO:0005783 |
None
|
ADORA1, APEX1, APP, BCL2, CA4, CYP19A1, CYP2D6, FLT3, GBA2, GRIK5, HSPA1A, KDR, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, XDH |
2.41533 |
|
[CC] GO:0005654 |
None
|
AKR1B1, ALOX5, APEX1, AR, AURKB, BCL2, CDC25B, CDK6, CSNK2A1, DNMT1, DUSP3, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, HIF1A, HSP90AA1, HSP90AB1, HSPA1A, NQO2, NR3C1, NR3C2, NUAK1, PGR, PIM1, POLA1, POLB, PPARA, PPARG, PRKCA, PRKCB, PRKCD, RORC, SMAD3, SRC, TERT, TNKS, TOP2A |
2.40719 |
|
[CC] GO:1903561 |
None
|
ABCB1, AKR1B1, AKR1B10, ALOX12, ALPL, AOX1, APP, AXL, CA1, CA2, CA4, CA6, CBR1, DUSP3, F3, FABP3, FABP4, FUCA1, GAA, GBA, GLO1, GRIA4, GRM5, HSP90AA1, HSP90AB1, HSPA1A, INSR, MGAM, MMP9, NQO2, PRKCA, PRKCB, PRKCD, PTGS1, SLC1A1, SLC22A2, SRC |
2.36724 |
|
[CC] GO:0043230 |
None
|
ABCB1, AKR1B1, AKR1B10, ALOX12, ALPL, AOX1, APP, AXL, CA1, CA2, CA4, CA6, CBR1, DUSP3, F3, FABP3, FABP4, FUCA1, GAA, GBA, GLO1, GRIA4, GRM5, HSP90AA1, HSP90AB1, HSPA1A, INSR, MGAM, MMP9, NQO2, PRKCA, PRKCB, PRKCD, PTGS1, SLC1A1, SLC22A2, SRC |
2.36615 |
|
[CC] GO:0098793 |
None
|
ADORA1, APP, CHRM1, CHRM2, CHRM3, GRIK5, SLC22A2 |
2.26319 |
|
[CC] GO:0031982 |
None
|
ABCB1, ADRB1, AKR1B1, AKR1B10, ALOX12, ALPL, AOX1, APP, AXL, BACE1, CA1, CA2, CA4, CA6, CBR1, DUSP3, EGFR, F3, FABP3, FABP4, FUCA1, GAA, GBA, GLO1, GRIA4, GRM5, HSP90AA1, HSP90AB1, HSPA1A, INSR, KDR, KIT, MGAM, MMP9, NQO2, PRKCA, PRKCB, PRKCD, PTGS1, PTPN1, SLC1A1, SLC22A2, SLC47A1, SRC, TYR |
2.25924 |
|
[CC] GO:0098802 |
None
|
CHRNA3, CHRNA7, GRIA2, GRIA4, GRIK5, GRM1, INSR |
2.15882 |
|
[CC] GO:0031224 |
None
|
ABCB1, ACHE, ADORA1, ADORA3, ADRB1, ALPL, APP, AXL, BACE1, CA12, CA14, CA4, CA9, CACNA1C, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA3, CHRNA7, CNR1, CNR2, EDNRA, EGFR, ERBB2, ESR1, F3, FLT3, FUT7, GBA2, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD11B1, HSD17B2, IGF1R, INSR, KDR, KIT, MET, MGAM, MPEG1, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, TBXAS1, TEK, TRPV1, TYR |
2.0693 |
|
[CC] GO:0070062 |
None
|
ABCB1, AKR1B1, AKR1B10, ALOX12, ALPL, AOX1, APP, AXL, CA1, CA2, CA4, CA6, CBR1, DUSP3, F3, FABP3, FABP4, FUCA1, GAA, GBA, GLO1, GRM5, HSP90AA1, HSP90AB1, HSPA1A, INSR, MGAM, MMP9, NQO2, PRKCA, PRKCB, PRKCD, PTGS1, SLC1A1, SLC22A2, SRC |
2.04884 |
|
[MF] GO:0046914 |
transition metal ion binding
|
ALOX12, ALOX15, ALOX5, AOX1, APP, AR, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DNMT1, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NR3C2, PGR, PIM1, PPARA, PPARG, PRKCA, PRKCB, PRKCG, PTPN1, RORC, SMAD3, TBXAS1, TNKS, TYR, XDH |
22.2341 |
|
[MF] GO:0043167 |
ion binding
|
ABCB1, ACHE, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AR, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CDK6, CHRM3, CHRNA3, CHRNA7, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DAO, DNMT1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, HSD17B1, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NR3C2, NUAK1, PGR, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SMAD3, SRC, TBXAS1, TEK, TERT, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH |
15.3636 |
|
[MF] GO:0003824 |
catalytic activity
|
ABCB1, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BACE1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CHRM1, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DAO, DNMT1, DUSP3, DYRK1A, EDNRA, EGFR, ERBB2, F3, FLT3, FUCA1, FUT7, GAA, GBA, GBA2, GLO1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSP90AA1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MGAM, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, SRC, TBXAS1, TEK, TERT, TNKS, TNKS2, TOP2A, TYR, XDH |
15.3453 |
|
[MF] GO:0004089 |
carbonate dehydratase activity
|
CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 |
14.7704 |
|
[MF] GO:0038023 |
signaling receptor activity
|
ADORA1, ADORA3, ADRB1, AR, AXL, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA3, CHRNA7, CNR1, CNR2, EDNRA, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, KIT, MET, NR3C1, NR3C2, PGR, PPARA, PPARG, RORC, TEK, TRPV1 |
14.1192 |
|
[MF] GO:0008270 |
zinc ion binding
|
AR, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DNMT1, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NR3C2, PGR, PPARA, PPARG, PRKCA, PRKCB, PRKCG, PTPN1, RORC, SMAD3, TNKS |
12.6782 |
|
[MF] GO:0060089 |
molecular transducer activity
|
ADORA1, ADORA3, ADRB1, AR, AXL, CDK6, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA3, CHRNA7, CNR1, CNR2, EDNRA, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, KIT, MET, NR3C1, NR3C2, PGR, PPARA, PPARG, RORC, TEK, TRPV1 |
12.6409 |
|
[MF] GO:0004872 |
receptor activity
|
ADORA1, ADORA3, ADRB1, AR, AXL, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA3, CHRNA7, CNR1, CNR2, EDNRA, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, KIT, MET, NR3C1, NR3C2, PGR, PPARA, PPARG, RORC, TEK, TRPV1 |
12.4256 |
|
[MF] GO:0004871 |
signal transducer activity
|
ADORA1, ADORA3, ADRB1, AR, AXL, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA3, CHRNA7, CNR1, CNR2, EDNRA, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, KIT, MET, NR3C1, NR3C2, PGR, PPARA, PPARG, PRKCE, RORC, SMAD3, TEK, TRPV1 |
12.3464 |
|
[MF] GO:0008144 |
drug binding
|
ABCB1, ACHE, AURKB, AXL, CDK6, CHRM1, CHRM2, CHRM3, CHRNA3, CHRNA7, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6, DYRK1A, EGFR, ERBB2, FLT3, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, TRPV1 |
12.2579 |
|
[MF] GO:0043169 |
cation binding
|
ACHE, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CHRM3, CHRNA3, CHRNA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DNMT1, ESR1, ESR2, ESRRA, ESRRB, GLO1, KIT, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NR3C2, NUAK1, PGR, PIM1, POLA1, POLB, PPARA, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SMAD3, TBXAS1, TERT, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH |
11.1663 |
|
[MF] GO:0016835 |
carbon-oxygen lyase activity
|
APEX1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, POLB |
10.0908 |
|
[MF] GO:0003707 |
steroid hormone receptor activity
|
AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, NR3C2, PGR, PPARA, PPARG, RORC |
9.88465 |
|
[MF] GO:0046872 |
metal ion binding
|
ALOX12, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DNMT1, ESR1, ESR2, ESRRA, ESRRB, GLO1, KIT, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NR3C2, NUAK1, PGR, PIM1, POLA1, POLB, PPARA, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SMAD3, TBXAS1, TERT, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH |
9.60121 |
|
[MF] GO:0016836 |
hydro-lyase activity
|
CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 |
8.88119 |
|
[MF] GO:0099600 |
transmembrane receptor activity
|
ADORA1, ADORA3, ADRB1, AXL, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA3, CHRNA7, CNR1, CNR2, EDNRA, EGFR, ERBB2, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, KIT, MET, PPARG, TEK, TRPV1 |
8.83118 |
|
[MF] GO:0004888 |
transmembrane signaling receptor activity
|
ADORA1, ADORA3, ADRB1, AXL, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA3, CHRNA7, CNR1, CNR2, EDNRA, EGFR, ERBB2, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, KIT, MET, PPARG, TEK, TRPV1 |
8.83118 |
|
[MF] GO:0016491 |
oxidoreductase activity
|
AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DAO, HSD11B1, HSD11B2, HSD17B1, HSD17B2, NQO2, PTGS1, PTGS2, TBXAS1, TYR, XDH |
8.71389 |
|
[MF] GO:0004714 |
transmembrane receptor protein tyrosine kinase activity
|
AXL, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, KIT, MET, TEK |
8.38426 |
|
[MF] GO:0042562 |
hormone binding
|
ACHE, AR, CHRM3, CHRNA3, CHRNA7, EGFR, HSD17B1, IGF1R, INSR, NQO2, NR3C1 |
8.3442 |
|
[MF] GO:0005496 |
steroid binding
|
AR, ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1, NR3C1, NR3C2, PGR, RORC |
8.30043 |
|
[MF] GO:0004672 |
protein kinase activity
|
AURKB, AXL, CDK6, CSNK2A1, DYRK1A, EGFR, ERBB2, FLT3, HSP90AA1, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK |
8.19418 |
|
[MF] GO:0004713 |
protein tyrosine kinase activity
|
AXL, DYRK1A, EGFR, ERBB2, FLT3, HSP90AA1, IGF1R, INSR, KDR, KIT, MET, PRKCD, SRC, TEK |
8.08077 |
|
[MF] GO:0098531 |
transcription factor activity, direct ligand regulated sequence-specific DNA binding
|
AR, ESR1, ESR2, ESRRA, ESRRB, PGR, PPARA, PPARG, RORC |
7.96168 |
|
[MF] GO:0004879 |
nuclear receptor activity
|
AR, ESR1, ESR2, ESRRA, ESRRB, PGR, PPARA, PPARG, RORC |
7.96168 |
|
[MF] GO:0005506 |
iron ion binding
|
ALOX12, ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, TBXAS1, XDH |
7.71134 |
|
[MF] GO:0019199 |
transmembrane receptor protein kinase activity
|
AXL, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, KIT, MET, TEK |
7.46231 |
|
[MF] GO:0016773 |
phosphotransferase activity, alcohol group as acceptor
|
AURKB, AXL, CDK6, CSNK2A1, DYRK1A, EGFR, ERBB2, FLT3, HSP90AA1, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK |
7.43513 |
|
[MF] GO:0030594 |
None
|
CHRM1, CHRM2, CHRM3, CHRM5, CHRNA3, CHRNA7, GRIA2, GRIA4, GRIK5, GRM1, GRM5 |
7.31706 |
|
[MF] GO:0016772 |
transferase activity, transferring phosphorus-containing groups
|
AURKB, AXL, CDK6, CSNK2A1, DYRK1A, EGFR, ERBB2, FLT3, HSP90AA1, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TERT |
7.21089 |
|
[MF] GO:0016712 |
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
|
CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6 |
7.17276 |
|
[MF] GO:0008066 |
None
|
GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 |
7.05418 |
|
[MF] GO:0016829 |
lyase activity
|
APEX1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, GLO1, POLB |
7.03805 |
|
[MF] GO:0016301 |
kinase activity
|
AURKB, AXL, CDK6, CSNK2A1, DYRK1A, EGFR, ERBB2, FLT3, HSP90AA1, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK |
6.7089 |
|
[MF] GO:0020037 |
heme binding
|
CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGS1, PTGS2, SRC, TBXAS1 |
6.63231 |
|
[MF] GO:0015464 |
None
|
CHRM1, CHRM2, CHRM3, CHRM5, CHRNA3, CHRNA7 |
6.59013 |
|
[MF] GO:0004716 |
signal transducer, downstream of receptor, with protein tyrosine kinase activity
|
EGFR, ERBB2, INSR, KDR, KIT |
6.57499 |
|
[MF] GO:0019899 |
enzyme binding
|
ADRB1, APP, AR, AURKB, BACE1, BCL2, CDC25B, CYP1A1, CYP1A2, CYP2A6, DUSP3, EGFR, ERBB2, ESR1, ESR2, ESRRB, F3, GRM5, HIF1A, HSP90AA1, HSP90AB1, HSPA1A, KIT, MET, NR3C1, PGR, POLA1, POLB, PPARA, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS2, TOP2A |
6.52539 |
|
[MF] GO:0046906 |
tetrapyrrole binding
|
CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGS1, PTGS2, SRC, TBXAS1 |
6.3363 |
|
[MF] GO:0036094 |
small molecule binding
|
ABCB1, ADORA1, AOX1, AURKB, AXL, CDK6, CSNK2A1, DAO, DNMT1, DYRK1A, EGFR, ERBB2, FABP3, FABP4, FLT3, HSD11B2, HSD17B1, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SLC1A1, SRC, TEK, TOP2A, TRPV1, XDH |
6.2302 |
|
[MF] GO:0043560 |
insulin receptor substrate binding
|
IGF1R, INSR, PIK3CA, PIK3CB, PRKCD |
6.08028 |
|
[MF] GO:0048037 |
cofactor binding
|
AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DAO, HSD11B2, HSD17B1, NQO2, POLA1, PTGS1, PTGS2, SRC, TBXAS1, XDH |
6.01186 |
|
[MF] GO:0070330 |
aromatase activity
|
CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6 |
5.95761 |
|
[MF] GO:0016907 |
None
|
CHRM1, CHRM2, CHRM3, CHRM5 |
5.89735 |
|
[MF] GO:0016705 |
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
|
CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGS1, PTGS2, TBXAS1, TYR |
5.86668 |
|
[MF] GO:0004497 |
monooxygenase activity
|
CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, TBXAS1, TYR |
5.64012 |
|
[MF] GO:0000166 |
nucleotide binding
|
ABCB1, AOX1, AURKB, AXL, CDK6, CSNK2A1, DAO, DNMT1, DYRK1A, EGFR, ERBB2, FLT3, HSD11B2, HSD17B1, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, TRPV1, XDH |
5.55543 |
|
[MF] GO:1901265 |
nucleoside phosphate binding
|
ABCB1, AOX1, AURKB, AXL, CDK6, CSNK2A1, DAO, DNMT1, DYRK1A, EGFR, ERBB2, FLT3, HSD11B2, HSD17B1, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, TRPV1, XDH |
5.55183 |
|
[MF] GO:0004697 |
None
|
PRKCA, PRKCB, PRKCD, PRKCE, PRKCG |
5.22117 |
|
[MF] GO:0030235 |
nitric-oxide synthase regulator activity
|
EGFR, ESR1, HSP90AA1, HSP90AB1 |
5.15002 |
|
[MF] GO:0005524 |
ATP binding
|
ABCB1, AURKB, AXL, CDK6, CSNK2A1, DYRK1A, EGFR, ERBB2, FLT3, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, TRPV1 |
5.06768 |
|
[MF] GO:0032559 |
adenyl ribonucleotide binding
|
ABCB1, AURKB, AXL, CDK6, CSNK2A1, DYRK1A, EGFR, ERBB2, FLT3, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, TRPV1 |
4.86817 |
|
[MF] GO:0030554 |
adenyl nucleotide binding
|
ABCB1, AURKB, AXL, CDK6, CSNK2A1, DYRK1A, EGFR, ERBB2, FLT3, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, TRPV1 |
4.81179 |
|
[MF] GO:0042802 |
identical protein binding
|
ACHE, AOX1, APP, BCL2, CHRNA7, CSNK2A1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, FLT3, GRIK5, HSP90AA1, HSP90AB1, IGF1R, KDR, KIT, MET, MMP9, NQO2, PGR, PPARG, PTGS2, SLC22A1, SMAD3, TERT, TOP2A, TRPV1, TYR, XDH |
4.70181 |
|
[MF] GO:0008289 |
lipid binding
|
ALOX15, AR, AXL, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, HSD11B2, HSD17B1, NR3C1, NR3C2, PGR, PPARA, PPARG, RORC, TRPV1 |
4.66422 |
|
[MF] GO:0016614 |
oxidoreductase activity, acting on CH-OH group of donors
|
AKR1B1, AKR1B10, AOX1, CBR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, XDH |
4.43115 |
|
[MF] GO:0043168 |
anion binding
|
ABCB1, ALOX15, AOX1, APP, AURKB, AXL, CDK6, CSNK2A1, DAO, DYRK1A, EGFR, ERBB2, F3, FABP3, FABP4, FLT3, HSD17B1, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SLC1A1, SRC, TEK, TOP2A, TRPV1, XDH |
4.33708 |
|
[MF] GO:0019825 |
oxygen binding
|
CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6 |
4.30706 |
|
[MF] GO:0005231 |
None
|
CHRNA3, CHRNA7, GRIA2, GRIA4, GRIK5, TRPV1 |
4.16607 |
|
[MF] GO:0004698 |
None
|
PRKCA, PRKCB, PRKCG |
4.06801 |
|
[MF] GO:0097159 |
organic cyclic compound binding
|
ABCB1, ADORA1, ADRB1, AOX1, APEX1, APP, AR, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DAO, DNMT1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FLT3, HIF1A, HSD11B2, HSD17B1, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, NQO2, NR3C1, NR3C2, NUAK1, PGR, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TERT, TOP2A, TRPV1, XDH |
3.9609 |
|
[MF] GO:0004629 |
None
|
ADORA1, CHRM1, CHRM3, CHRM5, EDNRA |
3.92473 |
|
[MF] GO:0046983 |
protein dimerization activity
|
ACHE, ADORA1, ADRB1, AOX1, AR, AXL, BCL2, CHRNA7, DAO, EGFR, ERBB2, FLT3, HIF1A, HSP90AA1, HSP90AB1, KIT, NQO2, PPARG, PTGS2, SLC22A1, SMAD3, TERT, TOP2A, TYR, XDH |
3.88602 |
|
[MF] GO:1901363 |
heterocyclic compound binding
|
ABCB1, ADORA1, AOX1, APEX1, APP, AR, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DAO, DNMT1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FLT3, HIF1A, HSD11B2, HSD17B1, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, NQO2, NR3C1, NR3C2, NUAK1, PGR, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TERT, TOP2A, TRPV1, XDH |
3.81792 |
|
[MF] GO:0019901 |
None
|
CDC25B, DUSP3, EGFR, ESR1, GRM5, HIF1A, HSP90AA1, HSP90AB1, NR3C1, POLA1, PRKCB, PRKCD, PTPN1, SMAD3, SRC, TOP2A |
3.7428 |
|
[MF] GO:0008395 |
steroid hydroxylase activity
|
CYP19A1, CYP1A1, CYP2A13, CYP2A6, CYP2D6 |
3.67167 |
|
[MF] GO:0019900 |
None
|
AURKB, CDC25B, DUSP3, EGFR, ESR1, GRM5, HIF1A, HSP90AA1, HSP90AB1, NR3C1, POLA1, PRKCB, PRKCD, PTPN1, SMAD3, SRC, TOP2A |
3.65499 |
|
[MF] GO:0015238 |
None
|
ABCB1, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2 |
3.61151 |
|
[MF] GO:0042166 |
None
|
ACHE, CHRM3, CHRNA3, CHRNA7 |
3.55893 |
|
[MF] GO:0005329 |
None
|
SLC22A1, SLC22A2, SLC22A3 |
3.4608 |
|
[MF] GO:0046934 |
phosphatidylinositol-4,5-bisphosphate 3-kinase activity
|
EGFR, ERBB2, KIT, MET, PIK3CA, PIK3CB |
3.44704 |
|
[MF] GO:0035639 |
purine ribonucleoside triphosphate binding
|
ABCB1, AURKB, AXL, CDK6, CSNK2A1, DYRK1A, EGFR, ERBB2, FLT3, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, TRPV1 |
3.36368 |
|
[MF] GO:0052813 |
phosphatidylinositol bisphosphate kinase activity
|
EGFR, ERBB2, KIT, MET, PIK3CA, PIK3CB |
3.34819 |
|
[MF] GO:0031072 |
heat shock protein binding
|
ADORA1, CSNK2A1, HIF1A, HSP90AB1, HSPA1A, KDR, NR3C1 |
3.33548 |
|
[MF] GO:0032555 |
purine ribonucleotide binding
|
ABCB1, AURKB, AXL, CDK6, CSNK2A1, DYRK1A, EGFR, ERBB2, FLT3, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, TRPV1 |
3.22124 |
|
[MF] GO:0098960 |
None
|
CHRNA3, CHRNA7, GRM1, GRM5 |
3.21686 |
|
[MF] GO:0035004 |
phosphatidylinositol 3-kinase activity
|
EGFR, ERBB2, KIT, MET, PIK3CA, PIK3CB |
3.19281 |
|
[MF] GO:0017076 |
purine nucleotide binding
|
ABCB1, AURKB, AXL, CDK6, CSNK2A1, DYRK1A, EGFR, ERBB2, FLT3, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, TRPV1 |
3.18006 |
|
[MF] GO:0032553 |
ribonucleotide binding
|
ABCB1, AURKB, AXL, CDK6, CSNK2A1, DYRK1A, EGFR, ERBB2, FLT3, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, TRPV1 |
3.17085 |
|
[MF] GO:0005230 |
None
|
CHRNA3, CHRNA7, GRIA2, GRIA4, GRIK5, TRPV1 |
3.16376 |
|
[MF] GO:0097367 |
carbohydrate derivative binding
|
ABCB1, ADORA1, APP, AURKB, AXL, CDK6, CSNK2A1, DYRK1A, EGFR, ERBB2, FLT3, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, TRPV1 |
3.15127 |
|
[MF] GO:0003674 |
molecular_function
|
ABCB1, ACHE, ADORA1, ADORA3, ADRB1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AR, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CBR1, CDC25B, CDK6, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA3, CHRNA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DAO, DNMT1, DUSP3, DYRK1A, EDNRA, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUCA1, FUT7, GAA, GBA, GBA2, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HIF1A, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MGAM, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NR3C2, NUAK1, PGR, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SMAD3, SRC, TBXAS1, TEK, TERT, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH |
3.07902 |
|
[MF] GO:0004674 |
protein serine/threonine kinase activity
|
AURKB, CDK6, CSNK2A1, DYRK1A, EGFR, NUAK1, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG |
3.06194 |
|
[MF] GO:0019902 |
phosphatase binding
|
BCL2, EGFR, ERBB2, MET, PPARA, PPARG, PTPN1, SMAD3 |
3.0226 |
|
[MF] GO:0016616 |
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
|
AKR1B1, AKR1B10, CBR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 |
3.0226 |
|
[MF] GO:0005057 |
signal transducer activity, downstream of receptor
|
ADRB1, EGFR, ERBB2, INSR, KDR, KIT, SMAD3 |
2.95958 |
|
[MF] GO:0022824 |
None
|
CHRNA3, CHRNA7, GRIA2, GRIA4, GRIK5 |
2.94198 |
|
[MF] GO:0022835 |
None
|
CHRNA3, CHRNA7, GRIA2, GRIA4, GRIK5 |
2.94198 |
|
[MF] GO:0008504 |
None
|
SLC22A1, SLC22A2, SLC22A3 |
2.92259 |
|
[MF] GO:0015651 |
None
|
SLC22A1, SLC22A2, SLC22A3 |
2.92259 |
|
[MF] GO:0016702 |
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
|
ALOX12, ALOX15, ALOX5, PTGS2 |
2.88104 |
|
[MF] GO:0004435 |
None
|
CHRM1, CHRM3, CHRM5, EDNRA |
2.82294 |
|
[MF] GO:0033764 |
steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
|
HSD11B1, HSD11B2, HSD17B1, HSD17B2 |
2.82294 |
|
[MF] GO:0016701 |
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen
|
ALOX12, ALOX15, ALOX5, PTGS2 |
2.82294 |
|
[MF] GO:0035258 |
None
|
ESR1, FLT3, PPARG, PRKCB, SMAD3, SRC |
2.82029 |
|
[MF] GO:0032403 |
protein complex binding
|
ACHE, ADORA1, APEX1, EGFR, ESRRB, FLT3, HSP90AA1, HSP90AB1, IGF1R, INSR, KDR, MMP12, MMP9, PPARA, PTPN1, SMAD3, SRC |
2.7546 |
|
[MF] GO:0008081 |
None
|
ADORA1, APEX1, CHRM1, CHRM3, CHRM5, EDNRA |
2.75318 |
|
[MF] GO:0016229 |
steroid dehydrogenase activity
|
HSD11B1, HSD11B2, HSD17B1, HSD17B2 |
2.72433 |
|
[MF] GO:0004666 |
prostaglandin-endoperoxide synthase activity
|
PTGS1, PTGS2 |
2.72433 |
|
[MF] GO:0038052 |
RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding
|
ESR1, ESR2 |
2.72433 |
|
[MF] GO:0047977 |
hepoxilin-epoxide hydrolase activity
|
ALOX12, ALOX15 |
2.72433 |
|
[MF] GO:0003845 |
None
|
HSD11B1, HSD11B2 |
2.72433 |
|
[MF] GO:0008389 |
None
|
CYP2A13, CYP2A6 |
2.72433 |
|
[MF] GO:0035403 |
None
|
PRKCA, PRKCB |
2.72433 |
|
[MF] GO:0008227 |
None
|
ADRB1, CHRM1, CHRM2, CHRM3, CHRM5 |
2.71683 |
|
[MF] GO:0009931 |
None
|
PRKCA, PRKCB, PRKCG |
2.69041 |
|
[MF] GO:0001540 |
amyloid-beta binding
|
ACHE, BACE1, CHRNA7, GRIA2, INSR |
2.62671 |
|
[MF] GO:0044877 |
macromolecular complex binding
|
ACHE, ADORA1, APEX1, CSNK2A1, EGFR, ESRRB, FLT3, HSP90AA1, HSP90AB1, IGF1R, INSR, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC |
2.61704 |
|
[MF] GO:0010857 |
None
|
PRKCA, PRKCB, PRKCG |
2.58686 |
|
[MF] GO:0051879 |
Hsp90 protein binding
|
CSNK2A1, HIF1A, KDR, NR3C1 |
2.58319 |
|
[MF] GO:0008134 |
transcription factor binding
|
APEX1, AR, BCL2, ESR1, ESRRB, FLT3, HIF1A, PIM1, PPARA, PPARG, PRKCB, SMAD3, SRC, TERT |
2.58073 |
|
[MF] GO:0035257 |
None
|
ESR1, FLT3, HIF1A, PPARG, PRKCB, SMAD3, SRC |
2.52099 |
|
[MF] GO:0140096 |
catalytic activity, acting on a protein
|
AURKB, AXL, BACE1, CDC25B, CDK6, CSNK2A1, DUSP3, DYRK1A, EGFR, ERBB2, F3, FLT3, HSP90AA1, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SRC, TEK |
2.45974 |
|
[MF] GO:0009055 |
electron transfer activity
|
AKR1B1, AOX1, CYP19A1, CYP1A2, NQO2, XDH |
2.4068 |
|
[MF] GO:0015926 |
None
|
GAA, GBA2, MGAM |
2.40526 |
|
[MF] GO:0004930 |
None
|
ADORA1, ADORA3, ADRB1, CHRM1, CHRM2, CHRM3, CHRM5, CNR1, CNR2, EDNRA, GPR35, GRM1, GRM3, GRM5, GRM8, HCAR2, PPARG |
2.34162 |
|
[MF] GO:0099528 |
None
|
CHRM1, CHRM2, CHRM3, CHRM5 |
2.33435 |
|
[MF] GO:0050473 |
arachidonate 15-lipoxygenase activity
|
ALOX15, PTGS2 |
2.33435 |
|
[MF] GO:1901375 |
None
|
SLC22A1, SLC22A2 |
2.33435 |
|
[MF] GO:0004949 |
None
|
CNR1, CNR2 |
2.33435 |
|
[MF] GO:0004052 |
arachidonate 12-lipoxygenase activity
|
ALOX12, ALOX15 |
2.33435 |
|
[MF] GO:0015307 |
None
|
SLC47A1, SLC47A2 |
2.33435 |
|
[MF] GO:0005333 |
None
|
SLC22A1, SLC22A2 |
2.33435 |
|
[MF] GO:0032450 |
None
|
GAA, MGAM |
2.33435 |
|
[MF] GO:0051120 |
hepoxilin A3 synthase activity
|
ALOX12, ALOX15 |
2.33435 |
|
[MF] GO:0005277 |
None
|
SLC22A1, SLC22A2 |
2.33435 |
|
[MF] GO:0099583 |
None
|
GRM1, GRM5 |
2.33435 |
|
[MF] GO:0008513 |
None
|
SLC22A1, SLC22A2 |
2.33435 |
|
[MF] GO:0004699 |
None
|
PRKCD, PRKCE |
2.33435 |
|
[MF] GO:0004348 |
None
|
GBA, GBA2 |
2.33435 |
|
[MF] GO:0042803 |
protein homodimerization activity
|
ACHE, AOX1, BCL2, CHRNA7, FLT3, HSP90AA1, HSP90AB1, KIT, NQO2, PTGS2, SLC22A1, SMAD3, TERT, TOP2A, TYR, XDH |
2.32184 |
|
[MF] GO:0019903 |
protein phosphatase binding
|
BCL2, EGFR, ERBB2, MET, PPARG, PTPN1 |
2.23936 |
|
[MF] GO:0035173 |
histone kinase activity
|
AURKB, PRKCA, PRKCB |
2.18964 |
|
[MF] GO:0051427 |
hormone receptor binding
|
ESR1, FLT3, HIF1A, PPARG, PRKCB, SMAD3, SRC |
2.18599 |
|
[MF] GO:0016903 |
None
|
AKR1B1, AKR1B10, AOX1, XDH |
2.1252 |
|
[MF] GO:0042578 |
None
|
ADORA1, ALPL, APEX1, CDC25B, CHRM1, CHRM3, CHRM5, DUSP3, EDNRA, PTPN1 |
2.10615 |
|
[MF] GO:0034056 |
estrogen response element binding
|
ESR1, ESR2 |
2.08296 |
|
[MF] GO:0004971 |
None
|
GRIA2, GRIA4 |
2.08296 |
|
[MF] GO:0051425 |
None
|
APP, INSR |
2.08296 |
|
[MF] GO:0004558 |
None
|
GAA, MGAM |
2.08296 |
|
[MF] GO:0004970 |
None
|
GRIA2, GRIA4, GRIK5 |
2.0693 |
|
[MF] GO:0005234 |
None
|
GRIA2, GRIA4, GRIK5 |
2.0693 |
|
[MF] GO:0033218 |
amide binding
|
ACHE, BACE1, CHRNA7, GRIA2, HSP90AB1, IGF1R, INSR, NQO2, PPARG |
2.06646 |
|
[MF] GO:0016798 |
None
|
APEX1, FUCA1, GAA, GBA, GBA2, MGAM |
2.05398 |
|
[MF] GO:0019838 |
growth factor binding
|
EGFR, ERBB2, IGF1R, INSR, KDR, TEK |
2.05398 |
|
[MF] GO:0001223 |
transcription coactivator binding
|
ESR1, PPARA, TERT |
2.01144 |
