TCM Prescription: Shu Jin Zhi Tong Ding



Prescription Description
Prescription IDTCMF5446
Pinyin NameShu Jin Zhi Tong Ding
Chinese Name舒筋止痛酊
English NameShu Jin Zhi Tong Ding
Function Description痹病
IndicationsArthritis, Rheumatoid arthritis
Disease ICD-11 Category FA2Z [Inflammatory arthropathies, unspecified, 炎性关节病，未特指的 ];
FA20 [Rheumatoid arthritis, 类风湿性关节炎 ];
Human Tissues Associated with IndicationSkeletalMuscle, Blood
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH222 Aconitum carmichaelii 草乌 TCMH222 ITSAH2410-14
TCMH447 Illicium difengpi 地枫皮 TCMH447 AF163728
TCMH2124 Speranskia tuberculata 透骨草 TCMH2124
TCMH865 Carthamus tinctorius 红花 TCMH865 ITSAI2447-14
TCMH1753 Boswellia carterii 乳香 TCMH1753
TCMH700 Drynaria fortunei 骨碎补 TCMH700 GBVM3977-11
TCMH1032 Impatiens balsamina 急性子 TCMH1032 ITSAD363-14
TCMH924 Zanthoxylum bungeanum 花椒 TCMH924 ITSAJ4650-14
TCMH517 Angelica pubescens 独活 TCMH517 ITSAF170-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT114 CNR2 Cannabinoid CB2 receptor GPCR P34972
TCMT115 CNR1 Cannabinoid CB1 receptor GPCR P21554
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT17 POLB DNA polymerase beta Transferase P06746
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT187 AR Androgen Receptor Nuclear receptor P10275
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT289 TBXAS1 Thromboxane-A synthase Isomerase P24557
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT336 IDO1 Indoleamine 2,3-dioxygenase Oxidoreductase P14902
TCMT337 XPO1 Exportin-1 Unclassified O14980
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT41 IDH1 Isocitrate dehydrogenase [NADP] cytoplasmic Oxidoreductase O75874
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT613 NR3C1 Glucocorticoid receptor Nuclear receptor P04150
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT636 POLA1 DNA polymerase alpha subunit Transferase P09884
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT689 TGM2 Protein-glutamine gamma-glutamyltransferase Transferase P21980
TCMT701 PTPN22 Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP Hydrolase Q9Y2R2
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT759 SAE1 SUMO-activating enzyme subunit 1 Unclassified Q9UBE0
TCMT783 NR3C2 Mineralocorticoid receptor Nuclear receptor P08235
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT81 ALOX12 Arachidonate 12-lipoxygenase Oxidoreductase P18054
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT904 PGR Progesterone receptor Nuclear receptor P06401
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718
TCMT974 GPER1 G-protein coupled estrogen receptor 1 GPCR Q99527
TCMT99 SHBG Testis-specific androgen-binding protein Unclassified P04278


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1175 Human immunodeficiency virus
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1183 Candida albicans SC5314
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1201 Staphylococcus epidermidis ATCC 12228
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1282 Colletotrichum orbiculare
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APP, AR, AXL, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FABP3, GPER1, HSD17B2, IDO1, IGF1R, INSR, MMP2, MMP9, NR3C1, POLB, PPARA, SRC, TEK, TYR 12.1969
[BP] GO:0010033 response to organic substance AKR1B1, ALPL, APP, AR, AXL, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, GPER1, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, MMP2, NR3C1, POLB, PPARA, SMAD3, SRC, TEK, TYR 11.9449
[BP] GO:0042221 response to chemical AKR1B1, ALPL, APP, AR, AXL, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, GPER1, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, MMP2, MMP9, NR3C1, POLB, PPARA, SMAD3, SRC, TEK, TYR 10.2203
[BP] GO:0033993 response to lipid ALPL, AR, AXL, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, GPER1, HSD17B2, IDO1, NR3C1, SRC, TYR 10.1293
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX5, APP, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, ESR1, FABP3, FABP4, FUT7, HSD11B1, HSD17B1, HSD17B2, MET, PPARA, TBXAS1 9.55506
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, ALOX12, APP, AR, CSNK2A1, CYP1B1, EGFR, ESR1, ESRRA, FABP3, FLT3, GPER1, HSPA1A, IDO1, IGF1R, INSR, KDR, MMP2, MMP9, NUAK1, PGR, PIM1, SMAD3, SRC, TEK, XDH 9.25978
[BP] GO:0043401 steroid hormone mediated signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, GPER1, NR3C1, NR3C2, PGR, PPARA, SRC 8.77534
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APP, AR, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, GPER1, IGF1R, INSR, MMP2, NR3C1, PPARA, SMAD3, SRC, TEK 8.67221
[BP] GO:0014070 response to organic cyclic compound ALPL, APP, AR, CA2, CA9, CNR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FLT3, GPER1, NR3C1, SRC, TEK, TYR 8.22945
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, ALOX12, APP, AR, AURKB, AXL, CA12, CA2, CA7, CNR1, CNR2, CYP19A1, CYP1A1, CYP1B1, EGFR, ESR1, FABP3, FABP4, FLT3, GPER1, GPR35, HSD11B1, HSD17B1, HSD17B2, HSPA1A, INSR, KDR, MET, POLA1, POLB, PPARA, SMAD3, SRC, TEK, XDH 8.2024
[BP] GO:0048513 animal organ development ACHE, AR, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, INSR, KDR, POLB, PPARA, SMAD3, SRC, TEK, TYR 8.14968
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX12, ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, FUT7, HSPA1A, IDO1, PIM1, PPARA, TBXAS1, TYR, XDH 8.14968
[BP] GO:0009725 response to hormone AKR1B1, ALPL, AR, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, GPER1, INSR, NR3C1, PPARA, SRC, TEK 8.10237
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, POLA1, POLB, PPARA, SMAD3, SRC, TBXAS1, TEK, TYR, XDH 8.10237
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 8.10237
[BP] GO:0009755 hormone-mediated signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, GPER1, NR3C1, NR3C2, PGR, PPARA, SRC 7.91558
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX12, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MMP1, MMP2, NR3C1, NR3C2, NUAK1, PGR, PIM1, POLA1, POLB, PPARA, SMAD3, SRC, TBXAS1, TEK, TYR, XDH 7.75683
[BP] GO:0030522 intracellular receptor signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, GPER1, NR3C1, PGR, PIM1, PPARA, SRC 7.75683
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, ESR1, HSD11B1, HSD17B1, HSD17B2 7.441
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, ALOX12, AR, AURKB, AXL, CNR1, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, GPER1, HSPA1A, IDO1, IGF1R, KDR, MET, MMP9, PIM1, PPARA, SMAD3, SRC, TEK, XDH 7.18048
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, ALOX12, AR, AURKB, AXL, CNR1, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, GPER1, HSPA1A, IDO1, IGF1R, KDR, MET, MMP9, PIM1, SMAD3, SRC, TEK, XDH 7.07566
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 7.01487
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, ALOX12, AR, AURKB, AXL, CSNK2A1, EGFR, HSPA1A, IDO1, IGF1R, KDR, MET, MMP9, PIM1, PPARA, SMAD3, SRC, TEK 6.65637
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, ALOX12, APP, AR, AURKB, AXL, CA2, CA7, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, GPER1, GPR35, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NR3C1, PGR, PIM1, PPARA, SMAD3, SRC, TEK, XDH 6.63042
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, ALOX12, APP, AXL, CA12, CA2, CA7, CNR1, EGFR, ESR1, FABP3, FABP4, FLT3, GPER1, GPR35, INSR, MET, POLA1, POLB, SMAD3, SRC 6.47742
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, ALOX12, AR, AURKB, AXL, CNR1, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, GPER1, HSPA1A, IDO1, IGF1R, KDR, MMP9, PIM1, SMAD3, SRC, TEK, XDH 6.46356
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, ALOX12, AR, AURKB, AXL, CSNK2A1, EGFR, HSPA1A, IDO1, IGF1R, KDR, MET, MMP9, PIM1, SMAD3, SRC, TEK 6.46356
[BP] GO:0019369 arachidonic acid metabolic process ALOX12, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TBXAS1 6.46356
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX12, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD11B1, HSD17B1, HSD17B2, IDO1, TBXAS1, TYR, XDH 6.27144
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, PIM1, SRC, TEK 6.19725
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX5, ALPL, APP, AR, AXL, CNR1, CNR2, CYP19A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESRRB, FABP4, GPER1, HSD17B2, IDO1, IGF1R, INSR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, SMAD3, SRC, TEK, TYR 6.19375
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX12, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TBXAS1 6.17738
[BP] GO:0080134 regulation of response to stress ADORA1, ALOX12, APP, CNR1, CNR2, CYP19A1, DUSP3, EGFR, ESR1, FABP4, GPER1, HSPA1A, IDO1, IGF1R, MET, MMP2, NUAK1, PPARA, SMAD3, SRC, TEK, XDH 6.00866
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 6.00515
[BP] GO:0006690 icosanoid metabolic process ALOX12, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TBXAS1 5.96428
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALPL, APP, AR, AXL, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP4, FLT3, GPER1, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NR3C1, SMAD3, SRC 5.90477
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, APP, AR, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, FLT3, GPER1, GPR35, HSPA1A, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, XDH 5.8348
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, ALOX12, AR, AURKB, AXL, CSNK2A1, EGFR, HSPA1A, IDO1, IGF1R, KDR, MMP9, PIM1, SMAD3, SRC, TEK 5.81314
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, APP, AR, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, FLT3, GPER1, GPR35, HSPA1A, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, XDH 5.81314
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, POLA1, POLB, PPARA, SMAD3, SRC, TBXAS1, TEK, TYR, XDH 5.81116
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, NR3C2, PGR, PPARA 5.81116
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, APP, AR, AURKB, AXL, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, FLT3, GPER1, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, SRC, TEK, XDH 5.77493
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALPL, APP, AR, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, INSR, KDR, MMP9, PGR, PIM1, POLB, PPARA, SMAD3, SRC, TEK, TYR 5.77493
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, ALOX12, APP, AR, AURKB, AXL, CA2, CA7, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GPER1, GPR35, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NR3C1, PGR, PIM1, PPARA, SMAD3, SRC, TEK, XDH 5.63129
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, ALOX12, APP, CYP19A1, CYP1B1, EGFR, GPER1, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 5.61454
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.56188
[BP] GO:0050727 regulation of inflammatory response ADORA1, CNR1, CNR2, CYP19A1, EGFR, ESR1, FABP4, GPER1, IDO1, PPARA, SMAD3, TEK 5.54171
[BP] GO:0030518 intracellular steroid hormone receptor signaling pathway AR, ESR1, ESR2, GPER1, NR3C1, PGR, SRC 5.51254
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALPL, APP, AR, AURKB, AXL, CA2, CA9, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, HSD11B1, HSD17B2, INSR, KDR, MET, MMP2, MMP9, PGR, PIM1, POLB, PPARA, SMAD3, SRC, TEK, TYR 5.39823
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD17B1, HSD17B2 5.33705
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.3221
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, APP, AR, AURKB, AXL, CA2, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, FLT3, GPER1, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, SMAD3, SRC, TEK, XDH 5.31566
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, ALOX12, APP, CYP19A1, CYP1B1, EGFR, GPER1, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 5.29273
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALPL, APP, AR, AURKB, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP4, FLT3, GPER1, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NR3C1, NUAK1, POLA1, POLB, SMAD3, SRC 5.28328
[BP] GO:0018212 peptidyl-tyrosine modification AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.28272
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CNR1, CYP19A1, CYP1A1, CYP1B1, EGFR, ESR1, GPER1, HSD11B1, HSD17B1, HSD17B2 5.27049
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALPL, APP, AR, AXL, CYP1A1, CYP1B1, EGFR, ESR1, FABP4, FLT3, GPER1, IGF1R, INSR, KDR, MMP2, NR3C1, SMAD3, SRC 5.21822
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, APP, AR, AURKB, AXL, CA2, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, FLT3, GPER1, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, SMAD3, SRC, TEK, XDH 5.21657
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, ALPL, APP, AR, AURKB, AXL, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, GPER1, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, MMP2, MMP9, NR3C1, NUAK1, POLA1, POLB, PPARA, SMAD3, SRC, TEK, TYR 5.2126
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX12, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, FABP3, FABP4, FUT7, MET, PPARA, TBXAS1 5.18158
[BP] GO:0048583 regulation of response to stimulus ADORA1, AKR1B1, ALOX12, APP, AR, AURKB, AXL, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, FABP4, FLT3, GPER1, GPR35, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MMP2, MMP9, NUAK1, PPARA, SMAD3, SRC, TEK, XDH 5.15368
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, POLA1, POLB, PPARA, SMAD3, SRC, TBXAS1, TEK, TYR, XDH 5.14708
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, APP, AR, AXL, CYP1B1, EGFR, FLT3, GPER1, GPR35, HSPA1A, INSR, KDR, MET, SRC, TEK, XDH 5.11755
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, APP, AR, AXL, CNR1, CSNK2A1, CYP1B1, EGFR, ESRRA, FABP4, FLT3, GPER1, GPR35, HSPA1A, IDO1, INSR, KDR, MET, MMP2, MMP9, SMAD3, SRC, TEK, XDH 5.07111
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APP, AR, CYP1A1, CYP1B1, EGFR, ESR1, FLT3, GPER1, NR3C1, SRC 5.07051
[BP] GO:0030335 positive regulation of cell migration ALOX12, APP, EGFR, GPER1, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 5.03605
[BP] GO:0006352 DNA-templated transcription, initiation AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, NR3C2, PGR, PPARA 5.035
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APP, CNR1, CNR2, EGFR, FABP3, FLT3, GPER1, IGF1R, INSR, MMP2, PPARA, SRC, TEK, TYR 4.97174
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, APP, AR, AURKB, AXL, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GPER1, GPR35, HSPA1A, IDO1, IGF1R, KDR, MET, MMP9, NR3C1, PIM1, PPARA, SMAD3, SRC, TEK, XDH 4.92029
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, ALOX12, APP, CYP19A1, CYP1B1, EGFR, GPER1, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 4.90025
[BP] GO:2000147 positive regulation of cell motility ALOX12, APP, EGFR, GPER1, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 4.89436
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX12, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TBXAS1 4.89436
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, ALOX12, APP, CYP19A1, CYP1B1, EGFR, GPER1, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 4.89288
[BP] GO:0010035 response to inorganic substance AKR1B1, APP, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, KDR, MMP9, SRC 4.86508
[BP] GO:1901568 fatty acid derivative metabolic process ALOX12, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TBXAS1 4.84494
[BP] GO:0032101 regulation of response to external stimulus ADORA1, ALOX12, CNR1, CNR2, CYP19A1, EGFR, ESR1, FABP4, GPER1, IDO1, KDR, MET, PPARA, SMAD3, TEK 4.84494
[BP] GO:0031347 regulation of defense response ADORA1, CNR1, CNR2, CYP19A1, EGFR, ESR1, FABP4, GPER1, HSPA1A, IDO1, MMP2, PPARA, SMAD3, SRC, TEK 4.82014
[BP] GO:0051272 positive regulation of cellular component movement ALOX12, APP, EGFR, GPER1, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 4.79667
[BP] GO:0006631 fatty acid metabolic process ALOX12, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PPARA, TBXAS1 4.79667
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7, CNR1, CNR2 4.7713
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.7032
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ALOX12, AR, CNR1, CNR2, CYP19A1, DUSP3, EGFR, ESR1, ESR2, GPER1, HSPA1A, IGF1R, MET, MMP9, PPARA, SMAD3, SRC, TEK, XDH 4.67493
[BP] GO:0040017 positive regulation of locomotion ALOX12, APP, EGFR, GPER1, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 4.6466
[BP] GO:0048878 chemical homeostasis AKR1B1, ALOX12, APP, CA12, CA2, CA7, CNR1, EGFR, ESR1, FABP3, FABP4, GPER1, GPR35, INSR, MET, SMAD3 4.61285
[BP] GO:1901698 response to nitrogen compound AKR1B1, APP, CNR1, CNR2, EGFR, FABP3, FLT3, GPER1, IGF1R, INSR, MMP2, PPARA, SRC, TEK, TYR 4.61285
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, APP, AR, AXL, CSNK2A1, CYP1B1, EGFR, FLT3, GPER1, GPR35, HSPA1A, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, XDH 4.55796
[BP] GO:0050728 negative regulation of inflammatory response ADORA1, CNR2, CYP19A1, GPER1, PPARA, SMAD3, TEK 4.53781
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, APP, AR, AURKB, AXL, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GPER1, GPR35, HSPA1A, IDO1, IGF1R, KDR, MET, MMP9, NR3C1, PGR, PIM1, PPARA, SMAD3, SRC, TEK, XDH 4.40747
[BP] GO:0071383 None AR, EGFR, FLT3, GPER1, NR3C1, SRC 4.37702
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APP, AR, AXL, CYP1B1, EGFR, ESR1, GPER1, IGF1R, INSR, MMP2, MMP9, NR3C1, SRC 4.27611
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, ALOX12, AR, CSNK2A1, EGFR, ESR1, FLT3, GPER1, IGF1R, INSR, KDR, MMP2, MMP9, PIM1, TEK 4.22012
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, ALOX12, APP, AR, AXL, CA2, CA7, CNR1, CSNK2A1, CYP19A1, CYP1B1, EGFR, GPER1, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, PPARA, SMAD3, SRC, TEK 4.18271
[BP] GO:0008283 cell proliferation ACHE, AR, AURKB, CYP1A1, EGFR, ESR1, FLT3, MET, PIM1, POLA1, SRC, TEK, TYR 4.17213
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CNR1, CNR2, CSNK2A1, CYP1B1, DUSP3, ESR1, FABP4, GPR35, IGF1R, MET, MMP9, PIM1, PPARA, SRC 4.15023
[BP] GO:0051130 positive regulation of cellular component organization APP, AR, AURKB, AXL, CNR1, ESR1, GPER1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, SMAD3, SRC, TEK 4.12757
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 3.98272
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APP, AR, EGFR, ESR1, FLT3, GPER1, IGF1R, INSR, MMP2, NR3C1, SMAD3, SRC 3.98272
[BP] GO:0022414 reproductive process AKR1B1, ALPL, APP, AR, AXL, CNR1, CYP19A1, CYP1A1, EGFR, ESR1, ESRRB, HSD17B2, IDO1, INSR, MMP2, MMP9, PGR, SRC 3.94929
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AOX1, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, FABP4, FUT7, HSPA1A, IDO1, MMP1, MMP2, MMP9, SRC, XDH 3.93819
[BP] GO:0051896 regulation of protein kinase B signaling AXL, EGFR, GPER1, INSR, MET, SRC, TEK, XDH 3.9249
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, APP, AR, AXL, CA1, CA2, CNR1, CNR2, CSNK2A1, CYP1B1, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPER1, GPR35, IGF1R, INSR, KDR, MET, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, POLB, PPARA, SMAD3, SRC, TEK 3.90161
[BP] GO:0032787 None ALOX12, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, IDO1, PPARA, TBXAS1 3.8843
[BP] GO:0051240 positive regulation of multicellular organismal process ALOX12, APP, AR, AXL, CA2, CNR1, CYP1B1, EGFR, ESRRB, GPER1, HSPA1A, IDO1, KDR, MET, MMP9, PIM1, SMAD3, SRC, TEK 3.85443
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, APP, AR, AURKB, CNR1, CNR2, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, FABP4, FLT3, GPER1, GPR35, HSPA1A, IGF1R, INSR, MET, MMP9, NUAK1, PIM1, PPARA, SMAD3, SRC, TEK, XDH 3.81877
[BP] GO:0048545 response to steroid hormone ALPL, AR, CA2, EGFR, FLT3, GPER1, NR3C1, SRC 3.81865
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, APP, CA2, CA7, CNR1, CNR2, EGFR, GPER1 3.79627
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, APP, CA2, CA7, CNR1, CNR2, EGFR, GPER1 3.79627
[BP] GO:0010676 None ESRRB, GPER1, INSR, PPARA, SRC 3.79627
[BP] GO:0043408 regulation of MAPK cascade ADORA1, APP, AR, DUSP3, EGFR, FLT3, GPER1, IGF1R, INSR, KDR, SRC, TEK, XDH 3.77698
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, SRC, TEK 3.735
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, APP, AR, DUSP3, EGFR, ESRRB, FABP3, FABP4, FLT3, GPER1, IGF1R, INSR, KDR, MMP9, NUAK1, PPARA, SMAD3, SRC, TEK, XDH 3.70535
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1B1, KDR, POLB, SRC 3.70491
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, INSR, MET, SMAD3, SRC 3.70491
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.69305
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6 3.68944
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6 3.68944
[BP] GO:0042493 response to drug AKR1B1, AXL, CA9, CNR1, CNR2, CYP1A1, CYP1B1, EGFR, FABP3, KDR, NR3C1, POLB, SRC 3.68339
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, APP, AR, DUSP3, EGFR, ESRRB, FABP3, FABP4, FLT3, GPER1, IGF1R, INSR, KDR, MMP9, NUAK1, PPARA, SMAD3, SRC, TEK, XDH 3.67383
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, APP, AR, EGFR, FLT3, GPER1, INSR, KDR, SRC, TEK, XDH 3.66334
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, AR, CNR2, DUSP3, EGFR, ESR1, ESR2, GPER1, GPR35, HSPA1A, IGF1R, MET, MMP9, SMAD3, SRC, XDH 3.66334
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, AR, CNR2, DUSP3, EGFR, ESR1, ESR2, GPER1, GPR35, HSPA1A, IGF1R, MET, MMP9, SMAD3, SRC, XDH 3.64759
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, CA2, CYP1A1, EGFR, HSPA1A, MMP2, POLB, PPARA, SMAD3, SRC, TEK, TYR 3.64248
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, APP, AR, AURKB, CNR1, CNR2, CSNK2A1, DUSP3, EGFR, ESR1, FABP4, FLT3, GPER1, HSPA1A, IGF1R, INSR, MMP9, NUAK1, SMAD3, SRC, TEK, XDH 3.59516
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ALOX12, APP, AR, AXL, CA2, CNR1, CYP1B1, EGFR, ESR1, ESRRA, ESRRB, GPER1, GPR35, HSPA1A, IDO1, INSR, KDR, MET, MMP9, PIM1, SMAD3, SRC, TEK, XDH 3.59516
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AOX1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, EGFR, HSPA1A, IDO1 3.54459
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, EGFR, MMP9, SRC 3.54091
[BP] GO:0050866 negative regulation of cell activation ALOX12, AXL, CNR1, CNR2, DUSP3, GPER1, IDO1 3.53635
[BP] GO:0031348 negative regulation of defense response ADORA1, CNR2, CYP19A1, GPER1, PPARA, SMAD3, TEK 3.52199
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD17B1, HSD17B2 3.51376
[BP] GO:1901654 None AKR1B1, AR, CA9, CSNK2A1, EGFR, NR3C1, SRC 3.41397
[BP] GO:1901652 response to peptide AKR1B1, APP, FABP3, GPER1, IGF1R, INSR, PPARA, SRC, TEK 3.34748
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, SMAD3, SRC, TEK 3.34088
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 3.30796
[BP] GO:0045913 None ESRRB, GPER1, INSR, PPARA, SRC 3.29606
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, APP, CA2, CA7, EGFR, GPER1 3.28144
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CNR1, CYP1A1, FABP3, FLT3, GPER1, PPARA, SRC, TEK 3.22295
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.22295
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, APP, AR, EGFR, ESRRB, FABP3, FLT3, GPER1, INSR, KDR, MMP9, SMAD3, SRC, TEK, XDH 3.19666
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, APP, AR, EGFR, ESRRB, FABP3, FLT3, GPER1, INSR, KDR, MMP9, SMAD3, SRC, TEK, XDH 3.19666
[BP] GO:0010907 None ESRRB, INSR, PPARA, SRC 3.19666
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC 3.19666
[BP] GO:0032496 response to lipopolysaccharide ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, IDO1, SRC 3.17285
[BP] GO:0032102 negative regulation of response to external stimulus ADORA1, ALOX12, CNR2, CYP19A1, GPER1, PPARA, SMAD3, TEK 3.15378
[BP] GO:0051094 positive regulation of developmental process ALOX12, APP, AR, AXL, CA2, CNR1, CYP1B1, ESRRB, GPER1, IDO1, INSR, KDR, PIM1, SMAD3, SRC, TEK 3.15378
[BP] GO:0002009 morphogenesis of an epithelium AR, CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC 3.12527
[BP] GO:0060736 prostate gland growth AR, CYP19A1, ESR1 3.10935
[BP] GO:0003006 developmental process involved in reproduction ALPL, AR, AXL, CYP19A1, EGFR, ESR1, ESRRB, HSD17B2, INSR, PGR, SRC 3.08058
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, APP, AR, AURKB, AXL, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, FLT3, GPER1, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, SMAD3, SRC, TEK, XDH 3.05118
[BP] GO:0019752 carboxylic acid metabolic process ALOX12, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, IDO1, PIM1, PPARA, TBXAS1, TYR 3.04258
[BP] GO:0070482 response to oxygen levels ADORA1, CYP1A1, MMP2, POLB, PPARA, SMAD3, SRC, TEK 3.04147
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPL, APP, AURKB, AXL, CSNK2A1, DUSP3, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, POLB, SRC, TEK, XDH 3.02403
[BP] GO:0045759 None CNR1, CNR2, GPR35 3.00352
[BP] GO:0002237 response to molecule of bacterial origin ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, IDO1, SRC 2.99422
[BP] GO:1901655 None AKR1B1, AR, EGFR, NR3C1, SRC 2.97417
[BP] GO:0009892 negative regulation of metabolic process ADORA1, APP, AR, AURKB, CNR1, CNR2, CSNK2A1, DUSP3, EGFR, ESR1, ESR2, ESRRA, FABP4, GPER1, HSPA1A, IGF1R, KDR, MET, MMP9, NR3C1, PGR, PPARA, SMAD3, SRC, XDH 2.96198
[BP] GO:0009891 positive regulation of biosynthetic process APP, AR, AURKB, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, GPER1, IGF1R, INSR, KDR, MET, NR3C1, PGR, PPARA, SMAD3, SRC 2.96198
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, APP, AR, AURKB, CSNK2A1, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPER1, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NR3C1, PGR, PPARA, SMAD3, SRC, TEK, XDH 2.94955
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.90583
[BP] GO:0009115 None AOX1, XDH 2.89606
[BP] GO:0010557 positive regulation of macromolecule biosynthetic process APP, AR, AURKB, EGFR, ESR1, ESR2, ESRRA, ESRRB, GPER1, IGF1R, INSR, KDR, MET, NR3C1, PGR, PPARA, SMAD3, SRC 2.89606
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, APP, AXL, CA2, CA9, CNR2, CYP1A1, CYP1A2, CYP1B1, EGFR, GPER1, HSPA1A, IDO1, MMP2, MMP9, NUAK1, POLA1, POLB, PPARA, SMAD3, SRC, TEK 2.89606
[BP] GO:0042058 None ADORA1, APP, EGFR, GPER1, MMP9 2.87219
[BP] GO:0042325 regulation of phosphorylation ADORA1, APP, AR, DUSP3, EGFR, ESRRB, FABP4, FLT3, GPER1, IGF1R, INSR, KDR, MMP9, PPARA, SRC, TEK, XDH 2.86778
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.82094
[BP] GO:0002695 negative regulation of leukocyte activation AXL, CNR1, CNR2, DUSP3, GPER1, IDO1 2.81224
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA 2.81224
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, SRC, TEK 2.80254
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, INSR, MET, SRC, TEK 2.80132
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPL, APP, AURKB, AXL, CSNK2A1, DUSP3, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, POLB, SRC, TEK, XDH 2.77411
[BP] GO:0031960 response to corticosteroid ALPL, EGFR, FLT3, GPER1, NR3C1, SRC 2.75909
[BP] GO:0050793 regulation of developmental process ALOX12, APP, AR, AXL, CA2, CNR1, CYP1B1, EGFR, ESR1, ESRRA, ESRRB, GPER1, IDO1, INSR, KDR, NUAK1, PIM1, PPARA, SMAD3, SRC, TEK, XDH 2.72167
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process APP, AR, AURKB, EGFR, ESR1, ESR2, ESRRA, ESRRB, GPER1, HSPA1A, IGF1R, INSR, MET, NR3C1, PGR, PPARA, SMAD3, SRC 2.71339
[BP] GO:2000026 regulation of multicellular organismal development ALOX12, APP, AR, AXL, CA2, CNR1, CYP1B1, EGFR, ESR1, ESRRA, GPER1, IDO1, INSR, KDR, PIM1, SMAD3, SRC, TEK, XDH 2.69738
[BP] GO:0048609 multicellular organismal reproductive process AKR1B1, APP, AR, AXL, CNR1, CYP1A1, EGFR, ESR1, PGR, SRC 2.68626
[BP] GO:0048732 gland development AR, CSNK2A1, CYP19A1, EGFR, INSR, SMAD3, TYR 2.6656
[BP] GO:0022900 electron transport chain AKR1B1, AOX1, CYP19A1, CYP1A2, IDO1, XDH 2.6656
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.6656
[BP] GO:0043436 oxoacid metabolic process ALOX12, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, IDO1, PIM1, PPARA, TBXAS1, TYR 2.65613
[BP] GO:0014066 regulation of phosphatidylinositol 3-kinase signaling EGFR, FLT3, GPER1, KDR, TEK 2.65531
[BP] GO:0071363 cellular response to growth factor stimulus APP, EGFR, INSR, KDR, NR3C1, SMAD3, SRC 2.63958
[BP] GO:1901184 None ADORA1, APP, EGFR, GPER1, MMP9 2.61618
[BP] GO:0006979 response to oxidative stress AKR1B1, APP, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC 2.60564
[BP] GO:0032870 cellular response to hormone stimulus AR, EGFR, ESR1, FLT3, GPER1, INSR, NR3C1, SRC 2.60564
[BP] GO:0000904 cell morphogenesis involved in differentiation AR, AXL, MET, SRC, TEK 2.60066
[BP] GO:0006082 organic acid metabolic process ALOX12, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, IDO1, PIM1, PPARA, TBXAS1, TYR 2.59074
[BP] GO:0009893 positive regulation of metabolic process ADORA1, APP, AR, AURKB, CSNK2A1, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, GPER1, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NR3C1, PGR, PPARA, SMAD3, SRC, TEK, XDH 2.59074
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.59074
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.59074
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, MET, SRC 2.59074
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, MET, SRC 2.59074
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, APP, AR, AURKB, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, GPER1, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NR3C1, PGR, PPARA, SMAD3, SRC, TEK, XDH 2.58949
[BP] GO:0072593 reactive oxygen species metabolic process ALOX12, CYP1A1, CYP1A2, CYP1B1, EGFR 2.57368
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, APP, AR, AURKB, CSNK2A1, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPER1, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NR3C1, PGR, PPARA, SMAD3, SRC, TEK, XDH 2.57215
[BP] GO:0051128 regulation of cellular component organization ALOX12, APP, AR, AURKB, AXL, CNR1, CSNK2A1, EGFR, ESR1, ESR2, GPER1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, SMAD3, SRC, TEK 2.56275
[BP] GO:0031328 positive regulation of cellular biosynthetic process APP, AR, AURKB, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, GPER1, IGF1R, INSR, MET, NR3C1, PGR, PPARA, SMAD3, SRC 2.56275
[BP] GO:0008285 negative regulation of cell proliferation ADORA1, ADORA3, APP, AR, CYP1B1, FABP3, GPER1, HSPA1A, IDO1, SMAD3, XDH 2.54711
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, CYP1B1, EGFR, MMP9, SRC 2.52781
[BP] GO:0048729 tissue morphogenesis AR, CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC 2.52639
[BP] GO:0001666 response to hypoxia ADORA1, CYP1A1, MMP2, PPARA, SMAD3, SRC, TEK 2.52293
[BP] GO:0071396 cellular response to lipid AR, AXL, EGFR, ESR1, FLT3, GPER1, NR3C1, SRC 2.52293
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, APP, AR, EGFR, ESRRB, FLT3, GPER1, INSR, KDR, MMP9, SRC, TEK, XDH 2.50907
[BP] GO:0060748 None AR, PGR 2.50907
[BP] GO:0046110 None AOX1, XDH 2.50907
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.50907
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, EGFR 2.49961
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.48703
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.48703
[BP] GO:0009611 response to wounding ACHE, ADORA3, CYP1A1, EGFR, PPARA, SMAD3 2.48107
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 2.46654
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, CA2, CA7, CNR1, EGFR, GPER1, KDR, SRC 2.4642
[BP] GO:0036293 response to decreased oxygen levels ADORA1, CYP1A1, MMP2, PPARA, SMAD3, SRC, TEK 2.45947
[BP] GO:0051254 None APP, AR, EGFR, ESR1, ESR2, ESRRA, ESRRB, GPER1, HSPA1A, INSR, MET, NR3C1, PGR, PPARA, SMAD3, SRC 2.44129
[BP] GO:0009653 anatomical structure morphogenesis APP, AR, AXL, CA2, CA9, CYP1B1, EGFR, ESR1, INSR, MET, MMP2, POLB, SMAD3, SRC, TEK 2.43687
[BP] GO:0048608 reproductive structure development AR, AXL, CYP19A1, ESR1, HSD17B2, INSR, SRC 2.43687
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 2.43687
[BP] GO:0045787 positive regulation of cell cycle APP, AURKB, CYP1A1, DUSP3, EGFR, GPER1, INSR, SRC 2.42617
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.41189
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade APP, DUSP3, EGFR, GPER1, KDR, SRC, TEK 2.40288
[BP] GO:0001503 ossification ALPL, EGFR, MMP2, MMP9, TEK 2.39382
[BP] GO:0010638 positive regulation of organelle organization AURKB, GPER1, HSPA1A, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 2.36119
[BP] GO:0032103 positive regulation of response to external stimulus CNR1, EGFR, FABP4, IDO1, KDR, MET, SMAD3 2.36119
[BP] GO:0070848 response to growth factor APP, EGFR, INSR, KDR, NR3C1, SMAD3, SRC 2.36119
[BP] GO:0071384 None EGFR, FLT3, GPER1, NR3C1 2.33649
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, EGFR, KDR, NR3C1, SRC 2.33504
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX12, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GPER1, GPR35, HSD17B1, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, POLA1, POLB, PPARA, SMAD3, SRC, TBXAS1, TEK, TYR, XDH 2.32669
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.32669
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, APP, AR, AURKB, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GPER1, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, POLA1, PPARA, SMAD3, SRC, TEK, XDH 2.32347
[BP] GO:0048511 rhythmic process AXL, CSNK2A1, EGFR, ESR1, PGR, PPARA, SRC 2.32347
[BP] GO:0002682 regulation of immune system process ADORA1, APP, AXL, CA2, CNR1, CNR2, CYP19A1, DUSP3, ESR1, ESRRA, GPER1, HSPA1A, IDO1, MMP2, SMAD3, SRC 2.31756
[BP] GO:0051090 regulation of DNA binding transcription factor activity ADORA3, APP, AR, CYP1B1, ESR1, ESR2, HSPA1A, PIM1 2.31756
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade APP, EGFR, GPER1, KDR, SRC, TEK 2.29505
[BP] GO:0010675 None ESRRB, GPER1, INSR, PPARA, SRC 2.29505
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.2792
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APP, EGFR, GPER1, IGF1R, INSR, MMP2, SRC 2.27737
[BP] GO:0006145 None AOX1, XDH 2.27737
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.27737
[BP] GO:0038171 None CNR1, CNR2 2.27737
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.27737
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, PPARA, SRC, TEK 2.27737
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, APP, AR, DUSP3, EGFR, FABP4, FLT3, GPER1, IGF1R, INSR, KDR, MMP9, SRC, TEK, XDH 2.27324
[BP] GO:0032355 response to estradiol CYP1A2, EGFR, ESR1, ESRRA, GPER1 2.26498
[BP] GO:1901575 None ACHE, ADORA1, AKR1B10, AOX1, AURKB, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, FABP4, FUT7, HSPA1A, IDO1, XDH 2.25602
[BP] GO:0042391 None ADORA1, APP, CNR1, CNR2, GPER1, GPR35, KDR, SRC 2.255
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, EGFR 2.255
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, SRC, TEK 2.255
[BP] GO:1902532 negative regulation of intracellular signal transduction DUSP3, ESR1, GPER1, HSPA1A, IGF1R, MET, MMP9, SRC, XDH 2.25395
[BP] GO:0051894 None KDR, SMAD3, TEK 2.25395
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.25395
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD17B1, HSD17B2 2.24608
[BP] GO:0043393 regulation of protein binding APP, AURKB, MET, MMP9, PPARA, SRC 2.23566
[BP] GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling FLT3, GPER1, KDR, TEK 2.22779
[BP] GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process CSNK2A1, GPER1, MMP9, SMAD3, SRC, XDH 2.22676
[BP] GO:0044093 positive regulation of molecular function ADORA1, APP, AR, AURKB, EGFR, ESR1, ESR2, FLT3, GPER1, HSPA1A, INSR, MET, MMP9, SMAD3, SRC, TEK, XDH 2.22582
[BP] GO:0002683 negative regulation of immune system process ADORA1, AXL, CNR1, CNR2, CYP19A1, DUSP3, GPER1, IDO1 2.22469
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, EGFR, GPER1, MMP2, MMP9 2.2219
[BP] GO:1901653 cellular response to peptide AKR1B1, APP, GPER1, IGF1R, INSR, SRC 2.21183
[BP] GO:2000021 regulation of ion homeostasis ADORA1, CA2, CA7, GPER1, KDR, SRC 2.21183
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AOX1, APP, AR, AURKB, AXL, CSNK2A1, CYP1A1, CYP1A2, DUSP3, EGFR, ESR1, FLT3, FUT7, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NUAK1, PIM1, POLB, PPARA, SMAD3, SRC, TEK, TYR, XDH 2.21183
[BP] GO:0040008 regulation of growth ALOX12, APP, AR, CSNK2A1, EGFR, ESR2, HSPA1A, INSR, PIM1, SMAD3 2.21183
[BP] GO:0045893 None APP, AR, EGFR, ESR1, ESR2, ESRRA, ESRRB, GPER1, INSR, MET, NR3C1, PGR, PPARA, SMAD3, SRC 2.19568
[BP] GO:1903508 None APP, AR, EGFR, ESR1, ESR2, ESRRA, ESRRB, GPER1, INSR, MET, NR3C1, PGR, PPARA, SMAD3, SRC 2.19568
[BP] GO:1902680 None APP, AR, EGFR, ESR1, ESR2, ESRRA, ESRRB, GPER1, INSR, MET, NR3C1, PGR, PPARA, SMAD3, SRC 2.19391
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALOX12, APP, CYP19A1, CYP1A1, CYP1B1, TYR 2.1833
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, IDO1 2.17688
[BP] GO:1903393 None KDR, SMAD3, TEK 2.17688
[BP] GO:0031399 regulation of protein modification process ADORA1, APP, AR, DUSP3, EGFR, FABP4, FLT3, GPER1, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, SRC, TEK, XDH 2.17046
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, APP, AR, EGFR, FLT3, GPER1, INSR, KDR, MMP9, SRC, TEK, XDH 2.16664
[BP] GO:1901360 None ACHE, AKR1B1, AKR1B10, ALOX12, AOX1, APP, AR, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, ESRRA, ESRRB, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IDO1, NR3C1, NR3C2, PGR, POLA1, POLB, PPARA, SMAD3, TYR, XDH 2.15787
[BP] GO:0050801 ion homeostasis APP, CA12, CA2, CA7, EGFR, ESR1, FABP3, GPER1, GPR35, SMAD3 2.14677
[BP] GO:0030155 regulation of cell adhesion ALOX12, CYP1B1, DUSP3, IDO1, KDR, NUAK1, PPARA, SMAD3, SRC, TEK 2.14677
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA 2.12356
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, SRC, TEK 2.11824
[BP] GO:2000241 regulation of reproductive process AR, CNR1, ESR1, INSR, SRC 2.10528
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APP, EGFR, GPER1, IGF1R, INSR, MMP2, SRC 2.10528
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, APP, AR, CSNK2A1, EGFR, ESR1, FLT3, GPER1, HSPA1A, INSR, KDR, MMP9, SMAD3, SRC, TEK, XDH 2.10528
[BP] GO:0010038 response to metal ion APP, CA2, CYP1A1, CYP1A2, EGFR, FABP4, MMP9 2.09896
[BP] GO:0046320 None CNR1, FABP3, PPARA 2.09896
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX12, CSNK2A1, CYP19A1, CYP1A1, HSD11B1, HSD17B1, HSD17B2 2.08704
[BP] GO:0001101 response to acid chemical AKR1B1, EGFR, FABP3, HSD17B2, KDR, MMP2, SRC 2.07761
[BP] GO:0050865 regulation of cell activation ALOX12, APP, AXL, CNR1, CNR2, DUSP3, GPER1, IDO1, SRC 2.06717
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, CNR1, EGFR, GPER1 2.06036
[BP] GO:0031100 animal organ regeneration AXL, CSNK2A1, EGFR, FLT3 2.04783
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9 2.04783
[BP] GO:0050678 None AR, EGFR, KDR, PGR, SMAD3, TEK, XDH 2.02614
[BP] GO:0035265 organ growth AR, CYP19A1, ESR1 2.02614
[BP] GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity FLT3, SRC, TEK 2.02614
[BP] GO:0042743 hydrogen peroxide metabolic process CYP1A1, CYP1A2, EGFR 2.02614
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX5, AOX1, APP, AR, AURKB, CA1, CA2, CA4, CA7, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, ESR1, ESR2, FABP3, FABP4, FLT3, FUT7, GPER1, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IDO1, INSR, KDR, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, POLA1, SMAD3, SRC, TBXAS1, TYR, XDH 2.4396
[CC] GO:0016323 basolateral plasma membrane ADORA1, CA2, CA4, CA9, EGFR, TEK 2.406
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ALOX12, ALOX5, ALPL, APP, AR, AXL, CA12, CA14, CA2, CA4, CA9, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, ESR1, FLT3, FUT7, GPER1, GPR35, HSD11B1, HSD17B2, IGF1R, INSR, KDR, MET, MMP2, NR3C2, PGR, PIM1, SMAD3, SRC, TBXAS1, TEK, TYR 2.36119
[CC] GO:0045121 membrane raft APP, CNR1, EGFR, INSR, KDR, SRC, TEK 2.26498
[CC] GO:0098857 membrane microdomain APP, CNR1, EGFR, INSR, KDR, SRC, TEK 2.255
[CC] GO:0005789 endoplasmic reticulum membrane CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, GPER1, HSD11B1, HSD17B2, NR3C2, TBXAS1 2.25395
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ALOX12, ALPL, APP, AR, AXL, CA12, CA14, CA2, CA4, CA9, CNR1, CNR2, CSNK2A1, EGFR, ESR1, FLT3, GPER1, GPR35, IGF1R, INSR, KDR, MET, MMP2, PIM1, SMAD3, SRC, TEK 2.14677
[CC] GO:0044432 endoplasmic reticulum part APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, FLT3, GPER1, HSD11B1, HSD17B2, NR3C2, TBXAS1 2.07243
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, APP, AXL, CA4, CNR1, CNR2, FLT3, GPER1, GPR35, IGF1R, INSR, KDR, MET, TEK 2.04937
[MF] GO:0046914 transition metal ion binding ALOX12, ALOX5, AOX1, APP, AR, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PPARA, SMAD3, TBXAS1, TYR, XDH 18.6928
[MF] GO:0043167 ion binding ACHE, ALOX12, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, POLA1, POLB, PPARA, SMAD3, SRC, TBXAS1, TEK, TYR, XDH 12.1865
[MF] GO:0003707 steroid hormone receptor activity AR, ESR1, ESR2, ESRRA, ESRRB, GPER1, NR3C1, NR3C2, PGR, PPARA 10.4972
[MF] GO:0005496 steroid binding AR, ESR1, ESR2, ESRRA, ESRRB, GPER1, HSD17B1, NR3C1, NR3C2, PGR, SHBG 10.4972
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 10.1293
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX5, ALPL, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, FLT3, FUT7, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NUAK1, PIM1, POLA1, POLB, SRC, TBXAS1, TEK, TYR, XDH 8.40463
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding AR, ESR1, ESR2, ESRRA, ESRRB, GPER1, PGR, PPARA 8.14968
[MF] GO:0004879 nuclear receptor activity AR, ESR1, ESR2, ESRRA, ESRRB, GPER1, PGR, PPARA 8.14968
[MF] GO:0043169 cation binding ACHE, ALOX12, ALOX5, ALPL, AOX1, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, ESRRA, ESRRB, IDO1, MMP1, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, POLA1, POLB, PPARA, SMAD3, TBXAS1, TYR, XDH 8.10685
[MF] GO:0005506 iron ion binding ALOX12, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TBXAS1, XDH 8.10137
[MF] GO:0042562 hormone binding ACHE, AR, EGFR, GPER1, HSD17B1, IGF1R, INSR, NR3C1, SHBG 7.88977
[MF] GO:0046872 metal ion binding ALOX12, ALOX5, ALPL, AOX1, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, ESRRA, ESRRB, IDO1, MMP1, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, POLA1, POLB, PPARA, SMAD3, TBXAS1, TYR, XDH 7.82024
[MF] GO:0008270 zinc ion binding AR, CA1, CA12, CA2, CA4, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP2, MMP9, NR3C1, NR3C2, PGR, PPARA, SMAD3 7.70435
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX12, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD11B1, HSD17B1, HSD17B2, IDO1, TBXAS1, TYR, XDH 7.52881
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 7.52881
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AR, AXL, CNR1, CNR2, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPER1, GPR35, IGF1R, INSR, KDR, MET, NR3C1, NR3C2, PGR, PPARA, TEK 7.12737
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9, POLB 6.91891
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 6.7552
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 6.7552
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, IDO1, SRC, TBXAS1 6.48781
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.4146
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, IDO1, SRC, TBXAS1 6.26065
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AR, AXL, CNR1, CNR2, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPER1, GPR35, IGF1R, INSR, KDR, MET, NR3C1, NR3C2, PGR, PPARA, TEK 6.24853
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TBXAS1, TYR 6.21855
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AR, AXL, CNR1, CNR2, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPER1, GPR35, IGF1R, INSR, KDR, MET, NR3C1, NR3C2, PGR, PPARA, SMAD3, TEK 6.19725
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AR, AXL, CNR1, CNR2, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPER1, GPR35, IGF1R, INSR, KDR, MET, NR3C1, NR3C2, PGR, PPARA, TEK 6.02985
[MF] GO:0008289 lipid binding AR, AXL, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GPER1, HSD17B1, NR3C1, NR3C2, PGR, PPARA, SHBG 5.53015
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD17B1, IDO1, POLA1, SRC, TBXAS1, XDH 5.48607
[MF] GO:0004713 protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.40301
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 5.38611
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PPARA, SRC, TEK 4.9267
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TBXAS1, TYR 4.84494
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9, POLB 4.32644
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 4.17623
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2, GPER1 4.151
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, HSD11B1, HSD17B1, HSD17B2, XDH 4.08221
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 4.07503
[MF] GO:0097159 organic cyclic compound binding ADORA1, AOX1, APP, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPER1, HSD17B1, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, NR3C1, NR3C2, NUAK1, PGR, PIM1, POLA1, POLB, PPARA, SHBG, SMAD3, SRC, TBXAS1, TEK, XDH 3.70491
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, POLA1, POLB, SRC, TEK 3.60252
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, IDO1, XDH 3.54091
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 3.41497
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR 3.35943
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6 3.15378
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, CSNK2A1, EGFR, ESRRB, FLT3, IGF1R, INSR, KDR, MMP9, PIM1, PPARA, SMAD3, SRC 3.08058
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 3.05118
[MF] GO:1901363 heterocyclic compound binding ADORA1, AOX1, APP, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, HSD17B1, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, NR3C1, NR3C2, NUAK1, PGR, PIM1, POLA1, POLB, PPARA, SMAD3, SRC, TBXAS1, TEK, XDH 2.96504
[MF] GO:0019899 enzyme binding APP, AR, AURKB, CYP1A1, CYP1A2, CYP2A6, DUSP3, EGFR, ESR1, ESR2, ESRRB, HSPA1A, MET, NR3C1, PGR, POLA1, POLB, PPARA, SMAD3, SRC, TEK 2.90481
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.89606
[MF] GO:0008389 None CYP2A13, CYP2A6 2.89606
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.76829
[MF] GO:0032403 protein complex binding ACHE, ADORA1, EGFR, ESRRB, FLT3, IGF1R, INSR, KDR, MMP9, PPARA, SMAD3, SRC 2.72824
[MF] GO:0031072 heat shock protein binding ADORA1, CSNK2A1, HSPA1A, KDR, NR3C1 2.52534
[MF] GO:0004949 None CNR1, CNR2 2.50907
[MF] GO:0036094 small molecule binding ADORA1, AOX1, AURKB, AXL, CSNK2A1, EGFR, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, POLA1, SRC, TEK, XDH 2.333
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, HSD11B1, HSD17B1, HSD17B2 2.32347
[MF] GO:0000978 None AR, ESR1, ESR2, ESRRA, NR3C1, PGR, PPARA, SMAD3 2.27737
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.27737
[MF] GO:0005497 None AR, SHBG 2.27737
[MF] GO:0051425 None APP, INSR 2.27737
[MF] GO:0019838 growth factor binding EGFR, IGF1R, INSR, KDR, TEK 2.19679
[MF] GO:0000987 None AR, ESR1, ESR2, ESRRA, NR3C1, PGR, PPARA, SMAD3 2.19391
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, AXL, CNR1, CNR2, EGFR, FLT3, GPER1, GPR35, IGF1R, INSR, KDR, MET, TEK 2.1833
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, AXL, CNR1, CNR2, EGFR, FLT3, GPER1, GPR35, IGF1R, INSR, KDR, MET, TEK 2.1833
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX12, ALOX5, IDO1 2.17688
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD17B1, HSD17B2 2.13707
[MF] GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen ALOX12, ALOX5, IDO1 2.13707
[MF] GO:0043559 insulin binding IGF1R, INSR 2.11732
[MF] GO:0042802 identical protein binding ACHE, AOX1, APP, CSNK2A1, EGFR, ESR1, ESR2, FLT3, IGF1R, KDR, MET, MMP9, PGR, SMAD3, TYR, XDH 2.08715
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD17B1, HSD17B2 2.06121
[MF] GO:0043548 phosphatidylinositol 3-kinase binding AXL, IGF1R, INSR 2.06121


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 9.401
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 10.9884
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, GPER1, MMP9, ESR1, EGFR, ESR2, HSPA1A 7.2552
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 7.3238
Metabolic pathways_Homo sapiens_hsa01100 AKR1B1, ALOX12, TYR, CYP19A1, HSD11B1, POLA1, CYP2A6, FUT7, AKR1B10, ALOX5, HSD17B1, TBXAS1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH, IDO1 6.3761
Adherens junction_Homo sapiens_hsa04520 SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R 6.787
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 5.4484
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, ESR1, EGFR, IGF1R 5.2929
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1, IDO1 5.3802
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, CNR1, INSR, KDR, TEK, MET, EGFR, IGF1R 5.2003
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9, EGFR 5.376
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 5.3161
Pathways in cancer_Homo sapiens_hsa05200 AR, SMAD3, FLT3, MMP1, MMP2, MMP9, MET, EGFR, IGF1R 4.1099
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KDR, MET, EGFR, IGF1R, HSPA1A 3.5791
Ras signaling pathway_Homo sapiens_hsa04014 INSR, KDR, TEK, MET, EGFR, IGF1R 3.0174
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1, AOX1 3.202
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CNR2, GPR35, CNR1, ADORA3, ADORA1, NR3C1 2.5745
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.1266
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, MET, EGFR, IGF1R 2.3758
HIF-1 signaling pathway_Homo sapiens_hsa04066 INSR, TEK, EGFR, IGF1R 2.5261
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 INSR, KDR, TEK, MET, EGFR, IGF1R 2.1884
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, INSR, EGFR, IGF1R 2.1884
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, INSR, ADORA1 2.2283
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 INSR, IGF1R, HSPA1A 2.1322
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, TBXAS1, ALOX12 2.1552
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET, EGFR 2.0911
MicroRNAs in cancer_Homo sapiens_hsa05206 PIM1, CYP1B1, MMP9, MET, EGFR 1.852
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 2.0884
Melanoma_Homo sapiens_hsa05218 MET, EGFR, IGF1R 2.0644
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 2.0613
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.852
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, CYP1A2, AOX1 2.0854
Prostate cancer_Homo sapiens_hsa05215 AR, EGFR, IGF1R 1.852
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, MMP2, PIM1 1.7338
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, EGFR 1.8371
Serotonergic synapse_Homo sapiens_hsa04726 APP, ALOX5, ALOX12 1.6474
Oocyte meiosis_Homo sapiens_hsa04114 AR, PGR, IGF1R 1.5615
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 1.4177
Hepatitis B_Homo sapiens_hsa05161 SMAD3, SRC, MMP9 1.3982
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, ESRRB, IGF1R 1.4177
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, INSR, ADORA1 1.2784
MAPK signaling pathway_Homo sapiens_hsa04010 DUSP3, EGFR, HSPA1A 0.9119
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC, ALOX12 0.9974
ErbB signaling pathway_Homo sapiens_hsa04012 SRC, EGFR 1.0545
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PGR, IGF1R 0.9974
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 INSR, IGF1R 1.0158
Insulin resistance_Homo sapiens_hsa04931 INSR, PPARA 0.9285
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.2923
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1, TEK 1.0427
Gap junction_Homo sapiens_hsa04540 SRC, EGFR 1.0531
Glioma_Homo sapiens_hsa05214 EGFR, IGF1R 1.2653
Platelet activation_Homo sapiens_hsa04611 SRC, TBXAS1 0.8814
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.3306
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, ESR1 0.8941
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.1338
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, HSPA1A 0.8941
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.8941
Measles_Homo sapiens_hsa05162 CSNK2A1, HSPA1A 0.8179
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, ADORA1 0.8877
Pancreatic cancer_Homo sapiens_hsa05212 SMAD3, EGFR 1.2608
Hepatitis C_Homo sapiens_hsa05160 PPARA, EGFR 0.8283
AMPK signaling pathway_Homo sapiens_hsa04152 INSR, IGF1R 0.8752
Wnt signaling pathway_Homo sapiens_hsa04310 SMAD3, CSNK2A1 0.8013
Phospholipase D signaling pathway_Homo sapiens_hsa04072 INSR, EGFR 0.8013
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.8074
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 INSR, PPARA 0.7878
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.311
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1, AOX1 0.7734
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, EGFR 0.7734
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, HSPA1A 0.6469
Purine metabolism_Homo sapiens_hsa00230 POLA1, XDH 0.7208
cAMP signaling pathway_Homo sapiens_hsa04024 ADORA1, PPARA 0.6469
Viral carcinogenesis_Homo sapiens_hsa05203 POLB, SRC 0.6469
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC, EGFR 0.6265
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 HSPA1A 0.342
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3258
HTLV-I infection_Homo sapiens_hsa05166 POLB, SMAD3 0.5496
Calcium signaling pathway_Homo sapiens_hsa04020 EGFR 0.3312
Tuberculosis_Homo sapiens_hsa05152 SRC 0.3317
Influenza A_Homo sapiens_hsa05164 HSPA1A 0.334
Alzheimer's disease_Homo sapiens_hsa05010 APP 0.342
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.3255
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.3682
Insulin signaling pathway_Homo sapiens_hsa04910 INSR 0.3972
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.4064
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 INSR, NR3C2 1.5901
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, XDH 1.4713
Cell cycle_Homo sapiens_hsa04110 SMAD3 0.4268
Axon guidance_Homo sapiens_hsa04360 MET 0.4217
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.4627
Melanogenesis_Homo sapiens_hsa04916 TYR 0.4832
Cholinergic synapse_Homo sapiens_hsa04725 ACHE 0.4627
Choline metabolism in cancer_Homo sapiens_hsa05231 EGFR 0.4832
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4832
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3 0.476
Pyrimidine metabolism_Homo sapiens_hsa00240 POLA1 0.4759
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4881
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4877
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 CNR1 0.4832
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.4968
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1 0.4923
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5018
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5018
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.5117
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5013
Peroxisome_Homo sapiens_hsa04146 XDH 0.5124
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.7476
Chronic myeloid leukemia_Homo sapiens_hsa05220 SMAD3 0.5496
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5484
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.537
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5539
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, TYR 1.6501
Bile secretion_Homo sapiens_hsa04976 CA2 0.5524
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5727
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.5745
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.5891
Shigellosis_Homo sapiens_hsa05131 SRC 0.5745
Colorectal cancer_Homo sapiens_hsa05210 SMAD3 0.5804
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3 0.5745
Non-small cell lung cancer_Homo sapiens_hsa05223 EGFR 0.6119
Endometrial cancer_Homo sapiens_hsa05213 EGFR 0.628
Legionellosis_Homo sapiens_hsa05134 HSPA1A 0.6146
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.7153
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.6474
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.9133
Malaria_Homo sapiens_hsa05144 MET 0.6469
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6469
Type II diabetes mellitus_Homo sapiens_hsa04930 INSR 0.6469
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.6469
African trypanosomiasis_Homo sapiens_hsa05143 IDO1 0.7411
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.7411
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.8013
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7734
DNA replication_Homo sapiens_hsa03030 POLA1 0.7345
Base excision repair_Homo sapiens_hsa03410 POLB 0.7552
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.7878
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.7878
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8013
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8013
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 5.3161
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 0.9788
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.266


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)