Component: Euphorbia kansui 甘遂


Description of the Component

Component ID
TCMH661
Latin Name
Euphorbia kansui
English Name
Kansui euphorbia
Chinese Pinyin Name
Gan Sui
中文名
甘遂
TCM Properties
Cold,Bitter
TCM Meridians
Lung,Large Intestine,Kidney
Therapeutic Class English
Purging
Therapeutic Class Chinese
泻下
Functions
cause drastic purgation and expel the retained water
Toxicity
NA
Geo-authentic habitats (道地产区)
Shanxi Province
Reference
Chinese Pharmacopoeia (2015)
Barcode ID
Barcode Source

TCM Prescriptions with the Component

Prescription ID Prescription English Name Prescription Chinese Name
TCMFx3743 Du Ji Du Jiao Ointment 杜记独角膏
TCMFx3586 Gu Zheng Pills 臌症丸
TCMFx2549 GZLS Brain Wakening Decoction
TCMF4231 Ke Chuan Ointment 咳喘膏
TCMFx1599 Kongxian Pills 控涎丸
TCMFx1231 Kongxian Pills 控涎丸
TCMFx1538 Major Chest Relieving Decoction 大陷胸汤
TCMFx5806 Qing Xin Gun Tan Pills 清心滚痰丸
TCMFx5006 Qing Yu Bi Wen Dan 庆余辟瘟丹
TCMFx490 Qing Yu Pi Wen Dan 庆余辟瘟丹
TCMFx5219 Qu Tan Zhi Ke Infusion 祛痰止咳冲剂
TCMFx5140 She Xiang Hui Yang Ointment 麝香回阳膏
TCMF5075 Shi Zao Pills 十枣丸
TCMF1670 Ten Jujube Decoction 十枣汤
TCMF2247 Vessel and Vehicle Pill 舟车丸
TCMF5332 Wan Ling Jin Gu Ointment 万灵筋骨膏
TCMF5998 Xiao Chuan Ointment 消喘膏
TCMFx6316 Zhou Che Pills 舟车丸
TCMF2252 Zhouju Pill

Targeted Human Proteins by the Ingredient of Component

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT1 EHMT2 Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 Transferase Q96KQ7
TCMT11 HIF1A Hypoxia-inducible factor 1 alpha Transcription factor Q16665
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT143 CA3 Carbonic anhydrase III Lyase P07451
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT17 POLB DNA polymerase beta Transferase P06746
TCMT18 GAA Lysosomal alpha-glucosidase Hydrolase P10253
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT221 ABCB11 Bile salt export pump Transporter O95342
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT248 CXCL8 Interleukin-8 Unclassified P10145
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT320 MMP3 Matrix metalloproteinase 3 Hydrolase P08254
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT6 NFKB1 Nuclear factor NF-kappa-B p105 subunit Transcription factor P19838
TCMT609 CTSL Cathepsin L Unclassified P07711
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT81 ALOX12 Arachidonate 12-lipoxygenase Oxidoreductase P18054
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372


Targeted Pathogenic Microbes by the Ingredient of Component

Target ID Target Name
TCMT1088 Carbonic anhydrase
TCMT1212 Verticillium dahliae
TCMT1246 Escherichia coli
TCMT1251 Candida albicans
TCMT1454 Bacillus subtilis
TCMT1462 Streptococcus mutans
TCMT1465 Entamoeba histolytica

Ingredient Structrues

Ingredient ID: TCMC7353
Formula: C41H47NO15

Ingredient ID: TCMC7094
Formula: C30H42O5

Ingredient ID: TCMC702
Formula: C8H8O2

Ingredient ID: TCMC696
Formula: C10H12O

Ingredient ID: TCMC6850
Formula: C38H60O8

Ingredient ID: TCMC6720
Formula: C30H46O6

Ingredient ID: TCMC6719
Formula: C32H44O7

Ingredient ID: TCMC6718
Formula: C30H42O6

Ingredient ID: TCMC6653
Formula: C30H50O

Ingredient ID: TCMC6470
Formula: C30H48O2

Ingredient ID: TCMC6469
Formula: C30H48O2

Ingredient ID: TCMC6414
Formula: C34H43NO12

Ingredient ID: TCMC6413
Formula: C42H48O14

Ingredient ID: TCMC6410
Formula: C32H44O7

Ingredient ID: TCMC6409
Formula: C30H42O6

Ingredient ID: TCMC5863
Formula: C30H42O6

Ingredient ID: TCMC5862
Formula: C30H42O6

Ingredient ID: TCMC5734
Formula: C32H44O7

Ingredient ID: TCMC5714
Formula: C41H47NO14

Ingredient ID: TCMC5639
Formula: C30H42O5

Ingredient ID: TCMC5406
Formula: C29H34O6

Ingredient ID: TCMC5405
Formula: C29H34O6

Ingredient ID: TCMC5247
Formula: C30H42O6

Ingredient ID: TCMC5155
Formula: C39H54O8

Ingredient ID: TCMC5154
Formula: C39H54O8

Ingredient ID: TCMC4506
Formula: C19H20O8

Ingredient ID: TCMC4081
Formula: C37H46O15

Ingredient ID: TCMC4051
Formula: C10H10O5

Ingredient ID: TCMC3840
Formula: C30H50O

Ingredient ID: TCMC3381
Formula: C30H50O

Ingredient ID: TCMC2639
Formula: C20H18O11

Ingredient ID: TCMC2201
Formula: C8H10O2

Ingredient ID: TCMC2035
Formula: C10H10O2

Ingredient ID: TCMC1976
Formula: C8H11NO3

Ingredient ID: TCMC1956
Formula: C7H6O4

Ingredient ID: TCMC1834
Formula: C8H8O3

Ingredient ID: TCMC1343
Formula: C6H6O2

Ingredient ID: TCMC1134
Formula: C10H12O

Properties

Ingredient ID Formulae Name MW AlogP MlogP XlogP # HBA # HBD PSA # Rotatable Bond # Ring # Heacy Atom Lipinski RO5 Violation
TCMC696 C10H12O Anethole 148.09 0.8555 2.45 3.979 0 0 9.23 4 1 11 0
TCMC702 C8H8O2 Anisaldehyde 136.05 -0.2442 2.12 2.003 1 0 26.3 3 1 10 0
TCMC1134 C10H12O Estragole 148.09 0.9769 2.45 3.658 0 0 9.23 4 1 11 0
TCMC1343 C6H6O2 Hydroquinone 110.04 -0.9206 1.9 0.87 0 2 40.46 2 1 8 0
TCMC1834 C8H8O3 P-Anisic Acid 152.05 -0.2916 2.01 1.589 2 1 46.53 4 1 11 0
TCMC1956 C7H6O4 Protocatechuic Acid 154.03 -1.1604 1.79 0.536 2 3 77.76 4 1 11 0
TCMC1976 C8H11NO3 Pyridoxine 169.07 -0.9182 1.9 -0.677 3 3 73.58 6 1 12 0
TCMC2035 C10H10O2 Safrole 162.07 0.726 2.34 2.93 0 0 18.46 2 2 12 0
TCMC2201 C8H10O2 Tyrosol 138.07 -0.6534 2.12 1.171 1 2 40.46 4 1 10 0
TCMC2639 C20H18O11 Reynoutrin 434.08 -4.3814 2.45 -0.111 6 7 186.37 10 4 31 1
TCMC3381 C30H50O Tirucallol 426.3861662 3.8675 4.65 10.21 1 1 20.23 4 4 31 1
TCMC3840 C30H50O Euphol 426.3861662 3.8675 4.65 10.21 1 1 20.23 4 4 31 1
TCMC4051 C10H10O5 Methyl(2,4-Dihydroxy-3-Formyl-6-Methoxy)Phenylketone 210.0528234 -1.4187 2.01 0.866 2 2 83.83 3 1 15 0
TCMC4081 C37H46O15 Kansuinin A 730.2836708 -0.4387 3.88 4.435 15 1 204.33 13 4 52 2
TCMC4506 C19H20O8 1,1'-Bis(2,6-Dihydroxy-3-Acetyl-4-Methoxyphenyl)Methane 376.1158176 -1.9964 2.67 0.24 2 4 133.52 6 2 27 0
TCMC5154 C39H54O8 20-O-Benzoyl-13-O-Dodecanoateingenol 650.3818687 -3.3408 4.87 9.113 8 3 130.36 16 5 47 2
TCMC5155 C39H54O8 3-O-Benzoyl-13-O-Dodecanoateingenol 650.3818687 -3.3408 4.87 9.113 8 3 130.36 16 5 47 2
TCMC5247 C30H42O6 3-O-(2'E,4'E-Decadienoyl)Ingenol 498.2981391 -0.2214 4.1 5.899 6 3 104.06 9 4 36 1
TCMC5405 C29H34O6 Kansuiphorin C 478.2355388 0.9766 3.99 5.883 6 1 89.9 5 5 35 1
TCMC5406 C29H34O6 Kansuiphorin D 478.2355388 0.9766 3.99 5.883 6 1 89.9 5 5 35 1
TCMC5639 C30H42O5 3-O-(2E,4E-Decadienoyl)-20-Deoxyingenol 482.3032244 0.8693 4.21 6.507 5 2 83.83 8 4 35 1
TCMC5714 C41H47NO14 Kansuinin E 777.2996552 0.048 4.32 5.423 15 0 200.29 14 5 56 3
TCMC5734 C32H44O7 3-O-(2'E,4'E-Decadienoyl)-20-O-Acetylingenol 540.3087037 0.1577 4.21 6.21 7 2 110.13 11 4 39 2
TCMC5862 C30H42O6 20-O-(2'E,4'E-Decadienoyl)Ingenol 498.2981391 -0.2214 4.1 5.899 6 3 104.06 9 4 36 1
TCMC5863 C30H42O6 5-O-(2'E,4'E-Decadienoyl)Ingenol 498.2981391 -0.2214 4.1 5.47 6 3 104.06 9 4 36 1
TCMC6409 C30H42O6 20-O-(2'E,4’Z-Decadienoyl)Ingenol 498.2981391 -0.2214 4.1 5.899 6 3 104.06 9 4 36 1
TCMC6410 C32H44O7 3-O-(2'E,4'Z-Decadienoyl)-5-O-Acetylingenol 540.3087037 0.1577 4.21 5.781 7 2 110.13 11 4 39 2
TCMC6413 C42H48O14 Kansuinin F 776.3044062 0.048 4.54 7.452 14 0 187.4 14 5 56 3
TCMC6414 C34H43NO12 Kansuinin G 657.2785258 -0.0985 3.77 2.967 13 0 173.99 11 4 47 2
TCMC6469 C30H48O2 Epi-Kansenone 440.3654308 3.3205 4.54 8.448 2 1 37.3 4 4 32 1
TCMC6470 C30H48O2 Kansenol 440.3654308 2.8727 4.54 8.761 2 2 40.46 4 4 32 1
TCMC6653 C30H50O Α-Euphol 426.3861662 3.8675 4.65 10.21 1 1 20.23 4 4 31 1
TCMC6718 C30H42O6 3-O-(2'E,4'Z-Decadienoyl)Ingenol 498.2981391 -0.2214 4.1 5.899 6 3 104.06 9 4 36 1
TCMC6719 C32H44O7 3-O-(2'E,4'Z-Decadienoyl)-20-O-Acetylingenol 540.3087037 0.1577 4.21 6.21 7 2 110.13 11 4 39 2
TCMC6720 C30H46O6 20-O-(Decanoyl)Ingenol 502.3294392 -2.4231 4.1 6.454 6 3 104.06 11 4 36 2
TCMC6850 C38H60O8 13-Oxyingenol-13-Dodecanoate-20-Hexanoate 644.4288189 -4.1187 4.76 8.327 8 3 130.36 19 4 46 2
TCMC7094 C30H42O5 3-O-(2E,4Z-Decadienoyl)-20-Deoxyingenol 482.3032244 0.8693 4.21 6.507 5 2 83.83 8 4 35 1
TCMC7353 C41H47NO15 Kansuinin D 793.2945698 -0.4486 4.21 5.152 16 1 217.22 14 5 57 3

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1. General Information of the Component  
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3. Putative Targets  
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