Prescription Description
| Prescription ID | TCMF4231 |
| Pinyin Name | Ke Chuan Gao |
| Chinese Name | 咳喘膏 |
| English Name | Ke Chuan Ointment |
| Function Description | 咳嗽, 喘病, 哮喘 |
| Indications | Dyspnea, Asthma |
| Disease ICD-11 Category |
MD11.5 [Dyspnoea, 呼吸困难
]; CA23 [Asthma, 哮喘 ]; |
| Human Tissues Associated with Indication | Lung |
| Reference | CFDA |
| Reference Book/link | http://samr.cfda.gov.cn/WS01/CL0001/ |
Prescription Components
| Component ID | Latin Name | Chinese Name | Component Quantity | Barcode |
|---|---|---|---|---|
| TCMH1090 | Brassica juncea | 芥子 | TCMH1090 | ITSAJ4546-14 |
| TCMH661 | Euphorbia kansui | 甘遂 | TCMH661 | |
| TCMH2376 | Corydalis yanhusuo | 延胡索 | TCMH2376 | |
| TCMH2239 | Asarum sieboldii | 细辛 | TCMH2239 | ITSAI1576-14 |
| TCMH2431 | Datura metel | 洋金花 | TCMH2431 | ITSAM3639-14 |
| TCMH1059 | Glycine max | 姜 | TCMH1059 | ITSAJ4675-14 |
| TCMH2585 | Cinnamomum camphora | 樟脑 | TCMH2585 | SDH069-14 |
| TCMH2403 | NA | 盐酸异丙嗪 | TCMH2403 |
Targeted Human Proteins by the Ingredients of Prescription
| Target ID | Gene Symbol | Target Name | Target Class | Uniprot ID |
|---|---|---|---|---|
| TCMT107 | GRIK2 | Glutamate receptor ionotropic kainate 2 | Ion channel | Q13002 |
| TCMT109 | GRIA2 | Glutamate receptor ionotropic, AMPA 2 | Ion channel | P42262 |
| TCMT110 | GRIA4 | Glutamate receptor ionotropic, AMPA 4 | Ion channel | P48058 |
| TCMT111 | GRIK5 | Glutamate receptor ionotropic kainate 5 | Ion channel | Q16478 |
| TCMT112 | ADORA3 | Adenosine A3 receptor | GPCR | P0DMS8 |
| TCMT130 | ALOX5 | Arachidonate 5-lipoxygenase | Oxidoreductase | P09917 |
| TCMT131 | ACHE | Acetylcholinesterase | Hydrolase | P22303 |
| TCMT133 | CA1 | Carbonic anhydrase I | Lyase | P00915 |
| TCMT134 | CA2 | Carbonic anhydrase II | Lyase | P00918 |
| TCMT135 | CA14 | Carbonic anhydrase XIV | Lyase | Q9ULX7 |
Showing 1 to 10 of 106 entries
Targeted Pathogenic Microbes by the Ingredients of Prescription
| Target ID | Target Name |
|---|---|
| TCMT1175 | Human immunodeficiency virus |
| TCMT1178 | Actinomyces viscosus |
| TCMT1189 | Pseudomonas fluorescens |
| TCMT1208 | Escherichia coli K12 |
| TCMT1209 | Staphylococcus haemolyticus |
| TCMT1210 | Streptococcus sobrinus |
| TCMT1211 | Fusobacterium nucleatum |
| TCMT1212 | Verticillium dahliae |
| TCMT1218 | Staphylococcus aureus |
| TCMT1221 | Human herpesvirus 4 |
Showing 1 to 10 of 42 entries
Gene Ontology Associated to Targeted Human Proteins
| GO Term | GO Name | Enriched Genes | Log10 Adjusted P-value |
|---|---|---|---|
| [BP] GO:0000302 | response to reactive oxygen species | AKR1B1, AXL, CYP1B1, EGFR, MMP9, PRKCD, SRC | 3.34288 |
| [BP] GO:0001505 | regulation of neurotransmitter levels | ACHE, CYP1B1, DRD1, DRD2, DRD3, EGFR, GRIK5, HTR1A, SLC1A1 | 4.08565 |
| [BP] GO:0001659 | None | ADORA1, ADRB1, DRD1, DRD2, HTR2A | 4.71171 |
| [BP] GO:0001932 | regulation of protein phosphorylation | ADORA1, ADRA1A, DRD1, DRD2, EGFR, ERBB2, F2, FABP4, FLT3, GRM1, GRM5, HTR2A, HTR2B, IGF1R, KDR, MIF, MMP9, PRKCD, SRC, XDH | 4.41181 |
| [BP] GO:0001934 | positive regulation of protein phosphorylation | ADORA1, ADRA1A, DRD2, EGFR, ERBB2, F2, FLT3, GRM1, GRM5, HTR2A, HTR2B, KDR, MIF, MMP9, PRKCD, SRC, XDH | 4.68336 |
| [BP] GO:0001963 | None | DRD1, DRD2, DRD3 | 2.78456 |
| [BP] GO:0001975 | None | DRD1, DRD2, DRD3 | 2.15479 |
| [BP] GO:0001996 | None | ADRA1A, ADRB1 | 2.57939 |
| [BP] GO:0001997 | None | ADRA1A, ADRB1 | 2.98899 |
| [BP] GO:0002027 | None | ADRA1A, ADRB1, CACNA1C, DRD2, SLC1A1 | 2.60654 |
Showing 1 to 10 of 490 entries
KEGG Pathways Associated to Targeted Human Proteins
| KEGG Pathway ID | Enriched Genes | Log10 Adjusted P-value |
|---|---|---|
| Acute myeloid leukemia_Homo sapiens_hsa05221 | FLT3, PIM1 | 1.3432 |
| Adherens junction_Homo sapiens_hsa04520 | CSNK2A1, SRC, ERBB2, MET, EGFR, IGF1R | 5.3425 |
| Adipocytokine signaling pathway_Homo sapiens_hsa04920 | PPARA | 0.5071 |
| Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | ADRB1, CACNA1C, ADRA1A | 1.3511 |
| AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | MMP2, PRKCD, PIM1, F3 | 2.5931 |
| Alcoholism_Homo sapiens_hsa05034 | DRD1, DRD2 | 0.6527 |
| Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | CACNA1C | 0.4715 |
| Alzheimer's disease_Homo sapiens_hsa05010 | CACNA1C | 0.3022 |
| Amphetamine addiction_Homo sapiens_hsa05031 | GRIA2, CACNA1C, DRD1, GRIA4 | 3.102 |
| AMPK signaling pathway_Homo sapiens_hsa04152 | ADRA1A, IGF1R | 0.845 |
Showing 1 to 10 of 147 entries
Target Exprsssion in Healthy Human Tissues (protein & mRNA level)
Protein expression data was from the "Human Proteome Map" datasetmRNA expression data was from the "GTEx" dataset
Average Target Expression (Fold Change) in Multiple Disease Conditions
Fold Change with Corresponding Normal SamplesClick each cell within the heatmap to access gene expression of individual patient samples