TCM Prescription: Xiao Chuan Ointment



Prescription Description
Prescription IDTCMF5998
Pinyin NameXiao Chuan Gao
Chinese Name消喘膏
English NameXiao Chuan Ointment
Function Description哮病, 喘病, 咳嗽, 肺胀
IndicationsWheezing disorder, Lung distension disorder, Dyspnea
Disease ICD-11 Category SA81 [Wheezing disorder (TM1), 哮病 (TM1) ];
SA82 [Lung distension disorder (TM1), 肺胀 (TM1) ];
MD11.5 [Dyspnoea, 呼吸困难 ];
Human Tissues Associated with IndicationLung
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1090 Brassica juncea 芥子 TCMH1090 ITSAJ4546-14
TCMH1903 Zingiber officinale 生姜 TCMH1903 ITSAO3969-14
TCMH2376 Corydalis yanhusuo 延胡索 TCMH2376
TCMH661 Euphorbia kansui 甘遂 TCMH661
TCMH2239 Asarum sieboldii 细辛 TCMH2239 ITSAI1576-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT107 GRIK2 Glutamate receptor ionotropic kainate 2 Ion channel Q13002
TCMT109 GRIA2 Glutamate receptor ionotropic, AMPA 2 Ion channel P42262
TCMT110 GRIA4 Glutamate receptor ionotropic, AMPA 4 Ion channel P48058
TCMT111 GRIK5 Glutamate receptor ionotropic kainate 5 Ion channel Q16478
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT160 HTR7 Serotonin 7 (5-HT7) receptor GPCR P34969
TCMT208 MAOA Monoamine oxidase A Oxidoreductase P21397
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT220 CYP2J2 Cytochrome P450 2J2 Oxidoreductase P51589
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT289 TBXAS1 Thromboxane-A synthase Isomerase P24557
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT301 PTGES Prostaglandin E synthase Isomerase O14684
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT313 HTR2B Serotonin 2b (5-HT2b) receptor GPCR P41595
TCMT315 HTR6 Serotonin 6 (5-HT6) receptor GPCR P50406
TCMT316 MTNR1A Melatonin receptor 1A GPCR P48039
TCMT317 MTNR1B Melatonin receptor 1B GPCR P49286
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT327 TRPV1 Vanilloid receptor Ion channel Q8NER1
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT34 CYP2D6 Cytochrome P450 2D6 Oxidoreductase P10635
TCMT36 HTR1A Serotonin 1a (5-HT1a) receptor GPCR P08908
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT37 HTR2A Serotonin 2a (5-HT2a) receptor GPCR P28223
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT407 MYLK Myosin light chain kinase, smooth muscle Kinase Q15746
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT565 EP300 Histone acetyltransferase p300 Transferase Q09472
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT615 SENP8 Sentrin-specific protease 8 Protease Q96LD8
TCMT616 SENP7 Sentrin-specific protease 7 Protease Q9BQF6
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT643 ADRA1A Alpha-1a adrenergic receptor GPCR P35348
TCMT646 HTR5A Serotonin 5a (5-HT5a) receptor GPCR P47898
TCMT651 DRD3 Dopamine D3 receptor GPCR P35462
TCMT653 GRM1 Metabotropic glutamate receptor 1 GPCR Q13255
TCMT654 GRM5 Metabotropic glutamate receptor 5 GPCR P41594
TCMT655 GRM2 Metabotropic glutamate receptor 2 GPCR Q14416
TCMT656 GRM3 Metabotropic glutamate receptor 3 GPCR Q14832
TCMT657 GRM4 Metabotropic glutamate receptor 4 GPCR Q14833
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT660 GRM8 Metabotropic glutamate receptor 8 GPCR O00222
TCMT664 SLC1A1 Excitatory amino acid transporter 3 Transporter P43005
TCMT675 ADRB1 Beta-1 adrenergic receptor GPCR P08588
TCMT683 MIF Macrophage migration inhibitory factor Isomerase P14174
TCMT704 ERBB2 Receptor protein-tyrosine kinase erbB-2 Kinase P04626
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT725 CACNA1C Voltage-gated L-type calcium channel alpha-1C subunit Ion channel Q13936
TCMT778 KCNA5 Voltage-gated potassium channel subunit Kv1.5 Ion channel P22460
TCMT780 CACNA1D Voltage-gated L-type calcium channel alpha-1D subunit Ion channel Q01668
TCMT781 CYP2E1 Cytochrome P450 2E1 Oxidoreductase P05181
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT807 SLC22A12 Solute carrier family 22 member 12 Transporter Q96S37
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT853 SIGMAR1 Sigma opioid receptor Unclassified Q99720
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1175 Human immunodeficiency virus
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1188 Leishmania braziliensis
TCMT1189 Pseudomonas fluorescens
TCMT1207 Legionella pneumophila
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1214 Enterococcus faecium
TCMT1218 Staphylococcus aureus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1283 Human enterovirus 71
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0007187 None ADORA1, ADRA1A, ADRB1, DRD1, DRD2, DRD3, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR5A, HTR6, HTR7, MTNR1A, MTNR1B 14.1907
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, ADRA1A, ADRB1, AKR1B1, AURKB, AXL, CA12, CA2, CA7, CACNA1C, CDK6, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, F3, FABP3, FABP4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HSD17B2, HTR1A, HTR2A, HTR2B, HTR7, KDR, MAOA, MET, MIF, MTNR1B, PPARA, SLC1A1, SRC, TRPV1, XDH 12.9897
[BP] GO:0007188 None ADORA1, ADRA1A, ADRB1, DRD1, DRD2, DRD3, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR5A, HTR7 10.8722
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, ADRA1A, CA2, CA7, DRD1, DRD2, DRD3, EGFR, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR2A 9.7997
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, ADRA1A, CA2, CA7, DRD1, DRD2, DRD3, EGFR, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR2A 9.7997
[BP] GO:0007193 None ADORA1, DRD2, DRD3, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR5A, HTR7 9.7997
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, DRD1, DRD2, EGFR, GRM1, GRM3, GRM5, GRM8, HTR2A 9.19797
[BP] GO:0007165 signal transduction ADORA1, ADORA3, ADRA1A, ADRB1, AKR1B1, AXL, CA1, CA2, CACNA1C, CDK6, CYP1B1, DRD1, DRD2, DRD3, EGFR, ERBB2, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, MIF, MMP2, MMP9, MTNR1A, MTNR1B, PIM1, PPARA, PTGES, SIGMAR1, SRC, TRPV1 8.96431
[BP] GO:0042592 homeostatic process ADORA1, ADRA1A, ADRB1, AKR1B1, AXL, CA12, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, EGFR, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HTR2A, HTR2B, MET, MTNR1B, SRC, TRPV1 8.69543
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, AXL, CDK6, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, EGFR, FABP3, GRIK5, GRM5, HSD17B2, HTR5A, IGF1R, MMP2, MMP9, PPARA, PTGES, SRC, TRPV1, TYR 8.42986
[BP] GO:0010033 response to organic substance ADRA1A, AKR1B1, ALPL, AXL, CA2, CDK6, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, EGFR, ERBB2, FABP3, FABP4, FLT3, GRIK5, GRM5, HSD17B2, HTR5A, IGF1R, KDR, MMP2, PPARA, PTGES, SRC, TRPV1, TYR 8.32162
[BP] GO:0042221 response to chemical ADRA1A, AKR1B1, ALPL, AXL, CA2, CDK6, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, EGFR, ERBB2, FABP3, FABP4, FLT3, GRIK5, GRM5, HSD17B2, HTR2A, HTR2B, HTR5A, IGF1R, KDR, MMP2, MMP9, PPARA, PTGES, SRC, TRPV1, TYR 8.3086
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, CA2, CA7, CACNA1C, CDK6, DRD1, DRD2, DRD3, EGFR, HTR2A, HTR2B, KDR, MIF, SRC, TRPV1 8.3086
[BP] GO:2000021 regulation of ion homeostasis ADORA1, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, HTR2A, HTR2B, KDR, SRC, TRPV1 8.25904
[BP] GO:0010647 positive regulation of cell communication ADORA1, ADRA1A, ADRB1, AKR1B1, AXL, CA2, CA7, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, ERBB2, F3, FLT3, GRM1, HTR2A, HTR2B, HTR6, KDR, MET, MIF, MMP9, SRC, XDH 7.94974
[BP] GO:0023056 positive regulation of signaling ADORA1, ADRA1A, ADRB1, AKR1B1, AXL, CA2, CA7, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, ERBB2, F3, FLT3, GRM1, HTR2A, HTR2B, HTR6, KDR, MET, MIF, MMP9, SRC, XDH 7.92107
[BP] GO:0007268 None DRD1, DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR6, HTR7, MTNR1B, SLC1A1 7.83919
[BP] GO:0098916 None DRD1, DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR6, HTR7, MTNR1B, SLC1A1 7.83919
[BP] GO:0099536 None DRD1, DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR6, HTR7, MTNR1B, SLC1A1 7.73546
[BP] GO:0099537 None DRD1, DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR6, HTR7, MTNR1B, SLC1A1 7.73546
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, ADRA1A, ADRB1, AKR1B1, AURKB, AXL, CA2, CA7, CACNA1C, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, ERBB2, F3, FLT3, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR6, IGF1R, KDR, MET, MIF, MMP9, MTNR1B, SRC, XDH 7.73546
[BP] GO:0048878 chemical homeostasis ADRA1A, AKR1B1, CA12, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, EGFR, FABP3, FABP4, GRIK5, GRM1, GRM5, HTR2A, HTR2B, MET, MTNR1B, TRPV1 7.60992
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, ADRA1A, ADRB1, AKR1B1, AURKB, AXL, CA2, CA7, CACNA1C, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, ERBB2, F3, FLT3, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR6, IGF1R, KDR, MET, MIF, MMP9, MTNR1B, SRC, XDH 7.60172
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD2, EGFR, ERBB2, FABP3, FABP4, FUT7, HSD17B2, MET, MIF, PPARA, PTGES, TBXAS1, TRPV1 7.46972
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, ADRA1A, ADRB1, AKR1B1, AXL, CYP1B1, DRD2, EGFR, ERBB2, F3, FLT3, GRM1, HTR2A, HTR2B, HTR6, KDR, MET, MIF, SRC, XDH 7.40272
[BP] GO:0007154 None ADORA1, ADRA1A, ADRB1, AXL, CACNA1C, DRD1, DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR6, HTR7, MTNR1B, SLC1A1, TRPV1 7.37333
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, ADRA1A, AKR1B1, CDK6, CYP1B1, DRD2, DRD3, EGFR, ERBB2, F3, FABP3, FLT3, HTR1A, HTR2A, HTR2B, IGF1R, KDR, MIF, MMP2, MMP9, PIM1, PTGES, SRC, XDH 7.34595
[BP] GO:0003018 None ADORA1, ADRA1A, ADRB1, DRD1, EGFR, HTR1A, HTR2A, HTR2B, HTR7, SRC 7.14482
[BP] GO:0007215 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 7.13406
[BP] GO:0007210 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 7.10555
[BP] GO:0098664 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 7.10555
[BP] GO:0023052 None ADORA1, ADRA1A, ADRB1, CACNA1C, DRD1, DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR6, HTR7, MTNR1B, SLC1A1 7.09251
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA1, ADORA3, ADRA1A, ADRB1, CA2, DRD1, DRD2, DRD3, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, MTNR1A, MTNR1B, SIGMAR1, SRC 7.03412
[BP] GO:0006939 None ADRA1A, DRD1, DRD2, HTR2A, HTR2B, HTR7, TRPV1 6.92713
[BP] GO:0032501 multicellular organismal process ADORA1, ADRA1A, ADRB1, AKR1B1, ALOX5, ALPL, AXL, CACNA1C, CYP19A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, EGFR, F3, FABP4, GRM1, GRM5, GRM8, HSD17B2, HTR1A, HTR2A, HTR2B, HTR7, IGF1R, MET, MMP1, MMP2, MMP9, PIM1, PPARA, SRC, TRPV1, TYR 6.90695
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ADRA1A, ADRB1, DRD1, DRD2, DRD3, EGFR, ERBB2, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HTR2A, HTR2B, IGF1R, KDR, MIF, MMP9, MTNR1A, PPARA, SRC, XDH 6.8871
[BP] GO:0007267 None ADORA1, ADRA1A, ADRB1, DRD1, DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR6, HTR7, MTNR1B, SLC1A1 6.87566
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ADRA1A, ADRB1, DRD1, DRD2, DRD3, EGFR, ERBB2, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HTR2A, HTR2B, IGF1R, KDR, MIF, MMP9, MTNR1A, PPARA, SRC, XDH 6.84129
[BP] GO:0097746 None ADORA1, ADRA1A, ADRB1, DRD1, EGFR, HTR1A, HTR2A, HTR2B, HTR7 6.79386
[BP] GO:0035296 None ADORA1, ADRA1A, ADRB1, DRD1, EGFR, HTR1A, HTR2A, HTR2B, HTR7 6.79386
[BP] GO:0019932 second-messenger-mediated signaling ADRA1A, ADRB1, CACNA1C, DRD1, DRD2, DRD3, EGFR, GRM5, HTR2B, HTR5A, KDR 6.73878
[BP] GO:0050880 None ADORA1, ADRA1A, ADRB1, DRD1, EGFR, HTR1A, HTR2A, HTR2B, HTR7 6.56514
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, AXL, CA2, CA7, CACNA1C, CDK6, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, ERBB2, F3, GRIK5, GRM5, HTR1A, HTR2A, HTR2B, IGF1R, KDR, MET, MIF, MMP9, MTNR1B, PPARA, SRC, TRPV1 6.56514
[BP] GO:0035150 None ADORA1, ADRA1A, ADRB1, DRD1, EGFR, HTR1A, HTR2A, HTR2B, HTR7 6.54703
[BP] GO:0001659 None ADORA1, ADRB1, DRD1, DRD2, HTR2A, TRPV1 6.50085
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, DRD1, DRD2, DRD3, EGFR, GRIK5, HTR1A, MAOA, SLC1A1, TRPV1 6.39488
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6, MIF, PTGES, TBXAS1 6.29074
[BP] GO:0003013 None ADORA1, ADRA1A, ADRB1, DRD1, EGFR, HTR1A, HTR2A, HTR2B, HTR7, SRC 6.14894
[BP] GO:0006690 icosanoid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6, MIF, PTGES, TBXAS1 6.06544
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, ADRA1A, ADRB1, AKR1B1, AURKB, AXL, CA2, CA7, CDK6, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, ERBB2, F3, FABP3, FLT3, GRIK5, GRM1, GRM5, HTR1A, HTR2A, HTR2B, HTR6, IGF1R, KDR, MET, MIF, MMP1, MMP2, MMP9, MTNR1A, PIM1, PPARA, SRC, TRPV1, XDH 6.01069
[BP] GO:0042493 response to drug ADRA1A, AKR1B1, AXL, CDK6, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, FABP3, HTR2A, HTR2B, KDR, SRC, TRPV1 5.96817
[BP] GO:0097756 None ADORA1, ADRA1A, HTR1A, HTR2A, HTR2B, HTR7 5.92038
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ADRA1A, ADRB1, DRD1, DRD2, EGFR, ERBB2, FABP3, FLT3, GRM1, GRM5, HTR2A, HTR2B, KDR, MIF, MMP9, MTNR1A, SRC, XDH 5.89961
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ADRA1A, ADRB1, DRD1, DRD2, EGFR, ERBB2, FABP3, FLT3, GRM1, GRM5, HTR2A, HTR2B, KDR, MIF, MMP9, MTNR1A, SRC, XDH 5.89961
[BP] GO:0009967 positive regulation of signal transduction ADORA1, ADRA1A, ADRB1, AKR1B1, AXL, CYP1B1, DRD2, DRD3, EGFR, ERBB2, F3, FLT3, GRM1, HTR2A, HTR2B, HTR6, KDR, MET, MIF, MMP9, SRC, XDH 5.88698
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, ADRA1A, ADRB1, AKR1B1, AURKB, AXL, CYP1B1, DRD2, DRD3, EGFR, ERBB2, F3, FLT3, GRM1, HTR2A, HTR2B, HTR6, IGF1R, KDR, MET, MIF, MMP9, SRC, XDH 5.87412
[BP] GO:0010035 response to inorganic substance AKR1B1, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, DRD2, EGFR, FABP4, KDR, MMP9, PTGES, SRC 5.77445
[BP] GO:0009628 response to abiotic stimulus ADORA1, ADRB1, AKR1B1, AURKB, CA2, CYP1A1, DRD1, DRD2, DRD3, EGFR, GRM1, HTR2A, HTR2B, MMP2, PPARA, SRC, TRPV1, TYR 5.74101
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, ADRA1A, ADRB1, AKR1B1, AURKB, AXL, CA2, CA7, CDK6, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, ERBB2, F3, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HTR1A, HTR2A, HTR2B, HTR6, IGF1R, KDR, MET, MIF, MMP1, MMP2, MMP9, MTNR1A, PIM1, PPARA, SLC1A1, SRC, TRPV1, XDH 5.73558
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, CDK6, DRD2, DRD3, EGFR, ERBB2, F3, FLT3, HTR1A, HTR2A, HTR2B, IGF1R, KDR, MIF, MMP2, MMP9, PIM1 5.7346
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, ADRB1, AKR1B1, DRD1, DRD2, HTR2A, MET, TRPV1 5.7015
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, CDK6, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, ERBB2, F3, IGF1R, KDR, MET, MIF, MMP9, SRC 5.70067
[BP] GO:0050801 ion homeostasis ADRA1A, CA12, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, EGFR, FABP3, GRM1, GRM5, HTR2A, HTR2B, TRPV1 5.68979
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, CACNA1C, CDK6, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, ERBB2, F3, IGF1R, KDR, MET, MIF, MMP9, SRC 5.6884
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7 5.65509
[BP] GO:0018958 None AKR1B1, DRD1, DRD2, DRD3, HTR1A, MAOA, TYR 5.61975
[BP] GO:0006811 None ADRA1A, CA1, CA12, CA14, CA2, CA4, CA7, CACNA1C, DRD1, DRD2, DRD3, FABP3, GRIA2, GRIA4, GRIK5, HTR2A, HTR2B, PPARA, SLC1A1, TRPV1 5.56058
[BP] GO:0007196 None GRM1, GRM3, GRM5, GRM8 5.41993
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, CDK6, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, ERBB2, F3, IGF1R, KDR, MET, MIF, MMP9, SRC 5.37797
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CACNA1C, CYP19A1, CYP1A1, CYP1B1, DRD2, EGFR, HSD17B2, HTR1A, HTR2A, MTNR1B 5.3446
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, DRD2, DRD3, FABP3, PPARA, SLC1A1, TRPV1 5.33305
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ADRA1A, DRD2, EGFR, ERBB2, FLT3, GRM1, HTR2A, HTR2B, KDR, MIF, SRC, XDH 5.33296
[BP] GO:0019748 secondary metabolic process AKR1B1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, TYR 5.30018
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, ADRA1A, ADRB1, AKR1B1, ALPL, AURKB, AXL, CA2, CDK6, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, EGFR, ERBB2, F3, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HSD17B2, HTR1A, HTR2A, HTR2B, HTR5A, IGF1R, KDR, MIF, MMP2, MMP9, PPARA, PTGES, SRC, TRPV1, TYR 5.28852
[BP] GO:0014070 response to organic cyclic compound ALPL, CA2, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, EGFR, FLT3, HTR5A, PTGES, SRC, TRPV1, TYR 5.27886
[BP] GO:0044255 cellular lipid metabolic process ACHE, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD2, EGFR, ERBB2, FABP3, FABP4, FUT7, MET, MIF, PPARA, PTGES, TBXAS1 5.26437
[BP] GO:0051046 None ACHE, ADORA1, CACNA1C, CYP19A1, DRD2, DRD3, EGFR, GRIK5, HTR1A, HTR2A, HTR2B, MIF, MTNR1B, SRC, TRPV1 5.23201
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2D6, PTGES, TBXAS1 5.18291
[BP] GO:0009719 response to endogenous stimulus ADRA1A, AKR1B1, ALPL, CA2, CYP1A2, DRD1, EGFR, ERBB2, FABP3, FLT3, GRM5, HTR5A, IGF1R, MMP2, PPARA, SRC, TRPV1 5.16463
[BP] GO:0051049 regulation of transport ACHE, ADORA1, AXL, CA2, CA7, CACNA1C, CYP19A1, DRD1, DRD2, DRD3, EGFR, ERBB2, GRIK5, GRM5, HTR1A, HTR2A, HTR2B, MIF, MMP9, MTNR1B, PPARA, SRC, TRPV1 5.1163
[BP] GO:0098771 inorganic ion homeostasis ADRA1A, CA12, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, EGFR, GRM1, GRM5, HTR2A, HTR2B, TRPV1 5.11332
[BP] GO:0044281 small molecule metabolic process AKR1B1, ALOX5, CA1, CA12, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, FUT7, HTR2B, MIF, PIM1, PPARA, PTGES, TBXAS1, TYR, XDH 5.05529
[BP] GO:0042310 None ADRA1A, HTR1A, HTR2A, HTR2B, HTR7 5.03068
[BP] GO:0051896 regulation of protein kinase B signaling AXL, DRD2, DRD3, EGFR, ERBB2, F3, MET, SRC, XDH 5.0268
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6, MIF, PTGES, TBXAS1 4.90372
[BP] GO:0006631 fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, MIF, PPARA, PTGES, TBXAS1 4.84476
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, ADRA1A, CA2, CA7, DRD2 4.81899
[BP] GO:1903530 regulation of secretion by cell ACHE, ADORA1, CACNA1C, CYP19A1, DRD2, DRD3, EGFR, GRIK5, HTR1A, HTR2A, HTR2B, MIF, MTNR1B, SRC 4.8177
[BP] GO:0050795 None ADORA1, DRD2, DRD3, HTR1A, HTR2A, HTR2B 4.78572
[BP] GO:0060402 None ADRA1A, CACNA1C, DRD2, HTR2A, HTR2B, TRPV1 4.78572
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALPL, AXL, CDK6, CYP1A1, CYP1A2, CYP1B1, DRD1, EGFR, ERBB2, FABP4, FLT3, GRIK5, GRM5, IGF1R, KDR, MMP2, MMP9, SRC, TRPV1 4.73714
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AURKB, AXL, CYP1B1, EGFR, F3, FLT3, GRIK5, HTR2B, IGF1R, KDR, MET, MIF, MMP9, PIM1, PPARA, SIGMAR1, SRC, TRPV1, XDH 4.73714
[BP] GO:1900542 None ADRB1, DRD1, DRD2, DRD3, GRM3, GRM8, HTR2A, MTNR1A, PPARA 4.68328
[BP] GO:0007216 None GRM1, GRM3, GRM5, GRM8 4.65613
[BP] GO:0042391 None ADORA1, ADRA1A, CACNA1C, DRD1, GRIA2, GRIA4, GRIK5, GRM5, KDR, SRC, TRPV1 4.65613
[BP] GO:0021885 forebrain cell migration AXL, DRD1, DRD2, EGFR, HTR6 4.65613
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALPL, AXL, CDK6, CYP1A1, CYP1B1, DRD1, EGFR, ERBB2, FABP4, FLT3, GRIK5, GRM5, IGF1R, KDR, MMP2, SRC, TRPV1 4.65613
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, AXL, CA1, DRD2, EGFR, ERBB2, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, MIF, MMP2, MMP9, SRC, TRPV1 4.62896
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, CYP1B1, EGFR, F3, FLT3, GRIK5, HTR2B, IGF1R, KDR, MET, MIF, MMP9, PIM1, SIGMAR1, SRC, TRPV1, XDH 4.60433
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7 4.6037
[BP] GO:0006140 None ADRB1, DRD1, DRD2, DRD3, GRM3, GRM8, HTR2A, MTNR1A, PPARA 4.59967
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ADRA1A, DRD2, EGFR, ERBB2, FLT3, GRM1, HTR2A, HTR2B, IGF1R, KDR, MIF, SRC, XDH 4.59931
[BP] GO:0007198 None HTR1A, HTR5A, HTR7 4.599
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, ADRA1A, ADRB1, AKR1B1, AXL, CYP1B1, DRD2, DRD3, EGFR, ERBB2, F3, FABP4, FLT3, GRM1, HTR2A, HTR2B, HTR6, KDR, MET, MIF, MMP2, MMP9, SRC, XDH 4.59831
[BP] GO:0035556 intracellular signal transduction ADRA1A, ADRB1, AKR1B1, AXL, CACNA1C, CYP1B1, DRD1, DRD2, DRD3, EGFR, ERBB2, GRM5, HTR2A, HTR2B, HTR5A, IGF1R, KDR, MET, MIF, SRC 4.59021
[BP] GO:0033993 response to lipid ALPL, AXL, CA2, CDK6, CYP1A1, CYP1A2, EGFR, FABP3, FLT3, HSD17B2, HTR5A, PTGES, SRC, TYR 4.58923
[BP] GO:0003008 None ADORA1, ADRA1A, ADRB1, AKR1B1, CYP1B1, DRD1, DRD2, DRD3, EGFR, GRM1, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR7, SRC, TRPV1, TYR 4.55346
[BP] GO:0030802 None ADRB1, DRD1, DRD2, DRD3, GRM3, GRM8, MTNR1A 4.53355
[BP] GO:0072507 divalent inorganic cation homeostasis ADRA1A, CACNA1C, DRD1, DRD2, DRD3, EGFR, GRM1, GRM5, HTR2A, HTR2B, TRPV1 4.50287
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, ADRA1A, CA2, CA7, DRD1, DRD2, EGFR 4.48976
[BP] GO:0044057 None ADORA1, ADORA3, ADRA1A, ADRB1, CACNA1C, DRD2, DRD3, EGFR, GRM1, HTR2A, SLC1A1, TRPV1 4.47986
[BP] GO:0055080 cation homeostasis ADRA1A, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, EGFR, GRM1, GRM5, HTR2A, HTR2B, TRPV1 4.45615
[BP] GO:0060401 None ADRA1A, CACNA1C, DRD2, HTR2A, HTR2B, TRPV1 4.41783
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, SRC 4.40009
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, EGFR, ERBB2, FLT3, GRM1, HTR2A, HTR2B, IGF1R, MIF, SRC 4.39206
[BP] GO:0060078 None ADORA1, GRIA2, GRIA4, GRIK5, GRM5, TRPV1 4.39206
[BP] GO:0018212 peptidyl-tyrosine modification AXL, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, SRC 4.35526
[BP] GO:0010243 response to organonitrogen compound AKR1B1, DRD1, DRD2, DRD3, EGFR, FABP3, FLT3, GRM5, IGF1R, MMP2, PPARA, SRC, TRPV1, TYR 4.34728
[BP] GO:1900371 None ADRB1, DRD1, DRD2, DRD3, GRM3, GRM8, MTNR1A 4.33312
[BP] GO:0007610 None DRD1, DRD2, DRD3, EGFR, GRM1, GRM5, HTR1A, HTR2A, HTR2B, MTNR1A, PPARA, TRPV1 4.33043
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, EGFR, ERBB2, FLT3, GRM1, HTR2A, HTR2B, MIF, SRC 4.33043
[BP] GO:0045776 None ADORA1, ADRB1, DRD2, DRD3, PPARA 4.32825
[BP] GO:0030808 None ADRB1, DRD1, DRD2, DRD3, GRM3, GRM8, MTNR1A 4.32081
[BP] GO:0055082 cellular chemical homeostasis ADRA1A, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, GRIK5, GRM1, GRM5, HTR2A, HTR2B, TRPV1 4.30117
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, DRD2, DRD3, FABP3, PPARA, SLC1A1, TRPV1 4.29924
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F3, IGF1R, KDR, MET, MIF, MMP9, SRC 4.29368
[BP] GO:0006584 None AKR1B1, DRD1, DRD2, DRD3, MAOA 4.29368
[BP] GO:0009712 None AKR1B1, DRD1, DRD2, DRD3, MAOA 4.29368
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, SRC 4.29368
[BP] GO:0046777 protein autophosphorylation AURKB, EGFR, ERBB2, FLT3, IGF1R, KDR, PIM1, SRC 4.2714
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade ADRA1A, DRD2, EGFR, HTR2A, HTR2B, KDR, MIF, SRC 4.25709
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ADRA1A, DRD2, EGFR, ERBB2, HTR2A, HTR2B, KDR, MIF, SRC 4.22295
[BP] GO:0007623 circadian rhythm DRD2, DRD3, EGFR, HTR7, MTNR1A, MTNR1B, PPARA 4.21291
[BP] GO:0030003 cellular cation homeostasis ADRA1A, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, GRM1, GRM5, HTR2A, HTR2B, TRPV1 4.14436
[BP] GO:0007200 None ADRA1A, DRD1, DRD2, GRM5, HTR2A, HTR2B 4.13298
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CDK6, CYP1B1, DRD1, EGFR, KDR, SRC, TRPV1 4.13298
[BP] GO:0048148 None DRD1, DRD2, DRD3, HTR2A 4.11446
[BP] GO:0048511 rhythmic process AXL, DRD2, DRD3, EGFR, HTR7, MTNR1A, MTNR1B, PPARA, SRC 4.11446
[BP] GO:0042325 regulation of phosphorylation ADORA1, ADRA1A, DRD1, DRD2, EGFR, ERBB2, FABP4, FLT3, GRM1, GRM5, HTR2A, HTR2B, IGF1R, KDR, MIF, MMP9, PPARA, SRC, XDH 4.11262
[BP] GO:0030799 None ADRB1, DRD1, DRD2, DRD3, GRM3, GRM8, MTNR1A 4.11262
[BP] GO:0051480 regulation of cytosolic calcium ion concentration ADRA1A, CACNA1C, DRD1, DRD2, GRM1, GRM5, HTR2A, HTR2B, TRPV1 4.11262
[BP] GO:1903522 None ADORA1, ADORA3, ADRA1A, ADRB1, CACNA1C, DRD2, EGFR, HTR2A, SLC1A1 4.11262
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, CYP1B1, EGFR, F3, FLT3, GRIK5, HTR2B, IGF1R, KDR, MIF, MMP9, PIM1, SIGMAR1, SRC, TRPV1, XDH 4.11262
[BP] GO:0032502 developmental process ACHE, ADORA1, ADRA1A, ADRB1, AKR1B1, ALPL, AURKB, AXL, CA2, CACNA1C, CDK6, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EGFR, ERBB2, FABP4, FLT3, FUT7, HSD17B2, HTR2A, HTR2B, HTR5A, KDR, MET, MIF, MMP2, MMP9, PIM1, PPARA, SIGMAR1, SRC, TYR 4.11259
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, ADRA1A, ADRB1, AKR1B1, ALOX5, ALPL, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CACNA1C, CDK6, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, EGFR, ERBB2, F3, FABP3, FABP4, FLT3, FUT7, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSD17B2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MAOA, MET, MIF, MMP1, MMP2, MMP9, MTNR1A, MTNR1B, NQO2, PIM1, PPARA, PTGES, SIGMAR1, SLC1A1, SRC, TBXAS1, TRPV1, TYR, XDH 4.09444
[BP] GO:0032845 None ADORA1, DRD2, HTR2A, HTR2B, MIF, SRC, TRPV1 4.08475
[BP] GO:0006873 cellular ion homeostasis ADRA1A, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, GRM1, GRM5, HTR2A, HTR2B, TRPV1 4.06735
[BP] GO:0019933 None ADRA1A, ADRB1, DRD1, DRD2, DRD3, HTR5A 4.05074
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ADRA1A, DRD2, EGFR, ERBB2, FLT3, GRM1, GRM5, HTR2A, HTR2B, KDR, MIF, MMP9, SRC, XDH 4.04942
[BP] GO:0006874 cellular calcium ion homeostasis ADRA1A, CACNA1C, DRD1, DRD2, DRD3, GRM1, GRM5, HTR2A, HTR2B, TRPV1 4.03837
[BP] GO:1901698 response to nitrogen compound AKR1B1, DRD1, DRD2, DRD3, EGFR, FABP3, FLT3, GRM5, IGF1R, MMP2, PPARA, SRC, TRPV1, TYR 4.0357
[BP] GO:0051047 None ACHE, ADORA1, CYP19A1, DRD2, DRD3, EGFR, HTR2B, MIF, SRC, TRPV1 4.03242
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ADRA1A, DRD1, DRD2, EGFR, ERBB2, FABP4, FLT3, GRM1, GRM5, HTR2A, HTR2B, IGF1R, KDR, MIF, MMP9, SRC, XDH 4.01621
[BP] GO:0051240 positive regulation of multicellular organismal process ADRA1A, ADRB1, AXL, CA2, CYP1B1, DRD2, DRD3, EGFR, F3, HTR2A, HTR2B, KDR, MET, MIF, MMP9, PIM1, SLC1A1, SRC, TRPV1 4.01366
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, ADRA1A, ADRB1, AURKB, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, EGFR, ERBB2, F3, FABP4, FLT3, GRM1, GRM3, GRM5, HTR2A, HTR2B, IGF1R, MET, MIF, MMP9, PIM1, PPARA, SRC, TRPV1, XDH 3.97919
[BP] GO:0055074 calcium ion homeostasis ADRA1A, CACNA1C, DRD1, DRD2, DRD3, GRM1, GRM5, HTR2A, HTR2B, TRPV1 3.93157
[BP] GO:0072503 cellular divalent inorganic cation homeostasis ADRA1A, CACNA1C, DRD1, DRD2, DRD3, GRM1, GRM5, HTR2A, HTR2B, TRPV1 3.88648
[BP] GO:0030817 None ADRB1, DRD1, DRD2, DRD3, GRM3, GRM8 3.88648
[BP] GO:0043269 regulation of ion transport ADORA1, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, GRM5, HTR1A, HTR2A, MIF, MMP9 3.88306
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, KDR, SRC 3.85541
[BP] GO:0001676 long-chain fatty acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2D6, PTGES, TBXAS1 3.84517
[BP] GO:0019935 None ADRA1A, ADRB1, DRD1, DRD2, DRD3, HTR5A 3.84517
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ADRA1A, DRD2, EGFR, ERBB2, FLT3, GRM1, GRM5, HTR2A, HTR2B, KDR, MIF, MMP9, SRC, XDH 3.84446
[BP] GO:0007202 None ADRA1A, EGFR, HTR2A, HTR2B 3.84365
[BP] GO:0045860 positive regulation of protein kinase activity ADORA1, DRD2, EGFR, ERBB2, FLT3, GRM1, GRM5, HTR2A, HTR2B, MIF, SRC 3.77712
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, HTR1A, MAOA, TYR 3.7528
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, ADRA1A, ADRB1, AURKB, DRD1, DRD2, DRD3, EGFR, ERBB2, F3, FABP4, FLT3, GRM1, GRM3, GRM5, HTR2A, HTR2B, IGF1R, MIF, MMP9, SRC, XDH 3.72341
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ADRA1A, ADRB1, AXL, CA2, CACNA1C, CDK6, CYP1B1, DRD2, DRD3, EGFR, ERBB2, F3, GRM1, HTR2A, HTR2B, KDR, MET, MIF, MMP9, PIM1, SLC1A1, SRC, TRPV1, XDH 3.72341
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, AXL, CDK6, CYP1B1, DRD1, EGFR, GRIK5, GRM5, IGF1R, MMP2, MMP9, SRC, TRPV1 3.71936
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, EGFR, MAOA 3.67805
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, EGFR, MMP9, SRC 3.67105
[BP] GO:0051940 None DRD1, DRD2, DRD3 3.65301
[BP] GO:0051584 None DRD1, DRD2, DRD3 3.65301
[BP] GO:0007204 positive regulation of cytosolic calcium ion concentration ADRA1A, CACNA1C, DRD1, DRD2, GRM1, HTR2A, HTR2B, TRPV1 3.6186
[BP] GO:0008283 cell proliferation ACHE, AURKB, CYP1A1, EGFR, ERBB2, FLT3, HTR1A, MET, MIF, PIM1, SRC, TYR 3.59448
[BP] GO:0042417 None DRD1, DRD2, DRD3, MAOA 3.59269
[BP] GO:0048513 animal organ development ACHE, ADRA1A, AXL, CA2, CACNA1C, CYP19A1, CYP1A1, CYP1A2, EGFR, ERBB2, FLT3, HSD17B2, KDR, PPARA, SRC, TYR 3.59056
[BP] GO:0051282 None CACNA1C, DRD1, DRD2, HTR2A, HTR2B, TRPV1 3.57158
[BP] GO:0009725 response to hormone ADRA1A, AKR1B1, ALPL, CA2, CYP1A2, EGFR, FABP3, FLT3, HTR5A, PPARA, SRC, TRPV1 3.56797
[BP] GO:0055065 metal ion homeostasis ADRA1A, CACNA1C, DRD1, DRD2, DRD3, EGFR, GRM1, GRM5, HTR2A, HTR2B, TRPV1 3.56643
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, DRD1, DRD2, HTR2A 3.55272
[BP] GO:0033674 positive regulation of kinase activity ADORA1, DRD2, EGFR, ERBB2, FLT3, GRM1, GRM5, HTR2A, HTR2B, MIF, SRC 3.54724
[BP] GO:0019725 cellular homeostasis ADRA1A, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, GRIK5, GRM1, GRM5, HTR2A, HTR2B, TRPV1 3.54717
[BP] GO:0009611 response to wounding ACHE, ADORA3, CYP1A1, DRD2, EGFR, ERBB2, PPARA 3.54143
[BP] GO:0045859 regulation of protein kinase activity ADORA1, DRD2, EGFR, ERBB2, FABP4, FLT3, GRM1, GRM5, HTR2A, HTR2B, IGF1R, MIF, SRC 3.53275
[BP] GO:0030814 None ADRB1, DRD1, DRD2, DRD3, GRM3, GRM8 3.52007
[BP] GO:0071073 None FABP3, HTR2A, HTR2B 3.50951
[BP] GO:0065007 biological regulation ACHE, ADORA1, ADORA3, ADRA1A, ADRB1, AKR1B1, AURKB, AXL, CA1, CA12, CA2, CA7, CACNA1C, CDK6, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, EGFR, ERBB2, F3, FABP3, FABP4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSD17B2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MAOA, MET, MIF, MMP1, MMP2, MMP9, MTNR1A, MTNR1B, PIM1, PPARA, PTGES, SIGMAR1, SLC1A1, SRC, TRPV1, XDH 3.50769
[BP] GO:0097164 None ACHE, AKR1B1, DRD1, DRD2, DRD3, HTR1A, MAOA 3.50624
[BP] GO:0071902 positive regulation of protein serine/threonine kinase activity ADORA1, EGFR, ERBB2, FLT3, GRM1, HTR2A, HTR2B, MIF, SRC 3.48018
[BP] GO:0002791 None ACHE, ADORA1, CACNA1C, DRD2, DRD3, EGFR, HTR2B, MIF, MTNR1B, SRC 3.46918
[BP] GO:0046883 regulation of hormone secretion ADORA1, CACNA1C, CYP19A1, DRD2, EGFR, HTR1A, HTR2A, MTNR1B 3.4682
[BP] GO:0003012 None ADORA1, ADRA1A, DRD1, DRD2, HTR2A, HTR2B, HTR7, TRPV1 3.45779
[BP] GO:0014065 phosphatidylinositol 3-kinase signaling ERBB2, HTR2A, HTR2B, IGF1R 3.44575
[BP] GO:0051347 positive regulation of transferase activity ADORA1, AURKB, DRD2, EGFR, ERBB2, FLT3, GRM1, GRM5, HTR2A, HTR2B, MIF, SRC 3.42814
[BP] GO:0060079 None ADORA1, GRIA2, GRIA4, GRIK5, TRPV1 3.42046
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, HTR2A, HTR2B, PPARA, SRC 3.3958
[BP] GO:0022029 None DRD1, DRD2, EGFR, HTR6 3.3958
[BP] GO:1903524 None ADRA1A, ADRB1, EGFR, HTR2A, SLC1A1 3.39459
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, EGFR, HTR2B, IGF1R, KDR, MET, MIF, MMP9, PIM1, PPARA, SRC 3.39373
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CYP1A1, DRD3, FABP3, FLT3, HTR2A, HTR2B, PPARA, SRC 3.3834
[BP] GO:2001225 regulation of chloride transport CA2, CA7, GRM5 3.3834
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.3834
[BP] GO:1900543 None DRD2, DRD3, GRM3, GRM8, PPARA 3.37482
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, ADRA1A, AKR1B1, ALPL, AXL, CA2, CACNA1C, CDK6, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EGFR, ERBB2, FLT3, HSD17B2, HTR5A, KDR, MMP9, PIM1, PPARA, SIGMAR1, SRC, TYR 3.37482
[BP] GO:0010863 positive regulation of phospholipase C activity ADRA1A, EGFR, HTR2A, HTR2B 3.35596
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALPL, AURKB, AXL, CA2, CDK6, CYP1A1, CYP1A2, CYP1B1, DRD1, EGFR, ERBB2, FABP4, FLT3, GRIK5, GRM1, GRM5, IGF1R, KDR, MIF, MMP2, MMP9, SRC, TRPV1 3.35395
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, SRC 3.35395
[BP] GO:0007189 None ADRA1A, ADRB1, DRD1, DRD2, DRD3 3.35395
[BP] GO:0045980 None DRD2, DRD3, GRM3, GRM8, PPARA 3.35395
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, AXL, CA2, CYP19A1, DRD1, DRD2, DRD3, EGFR, ERBB2, HTR2B, MIF, SRC, TRPV1 3.35118
[BP] GO:0090066 None ADORA1, ADRA1A, ADRB1, DRD1, EGFR, HTR1A, HTR2A, HTR2B, HTR7 3.34297
[BP] GO:0016477 cell migration AXL, CYP1B1, DRD1, DRD2, EGFR, FUT7, HTR2B, HTR6, KDR, MIF, MMP1, MMP9, SRC 3.31852
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ADRA1A, ADRB1, AURKB, DRD1, DRD2, DRD3, EGFR, ERBB2, F3, FABP3, FLT3, GRM1, GRM5, HTR2A, HTR2B, IGF1R, KDR, MET, MIF, MMP9, MTNR1A, PPARA, SRC, TRPV1, XDH 3.30931
[BP] GO:0032787 None ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, MIF, PPARA, PTGES, TBXAS1 3.289
[BP] GO:0002031 None DRD2, DRD3, HTR2B 3.26905
[BP] GO:0051952 None ADORA1, DRD1, DRD2, DRD3, HTR2A 3.25078
[BP] GO:0043549 regulation of kinase activity ADORA1, DRD2, EGFR, ERBB2, FABP4, FLT3, GRM1, GRM5, HTR2A, HTR2B, IGF1R, MIF, SRC 3.25029
[BP] GO:0006875 cellular metal ion homeostasis ADRA1A, CACNA1C, DRD1, DRD2, DRD3, GRM1, GRM5, HTR2A, HTR2B, TRPV1 3.24954
[BP] GO:1900274 regulation of phospholipase C activity ADRA1A, EGFR, HTR2A, HTR2B 3.22528
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, EGFR, HTR2B, IGF1R, KDR, MET, MIF, MMP9, PIM1, SRC 3.14812
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, MMP2, MMP9, SRC 3.14784
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, AURKB, AXL, CDK6, CYP19A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, EGFR, ERBB2, FABP3, FABP4, GRM3, GRM8, HTR2A, HTR2B, IGF1R, KDR, MET, MIF, MMP9, PIM1, PPARA, PTGES, SRC, TRPV1, XDH 3.14435
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADORA1, EGFR, ERBB2, FLT3, GRM1, HTR2A, HTR2B, IGF1R, MIF, SRC 3.12073
[BP] GO:0051338 regulation of transferase activity ADORA1, AURKB, DRD2, EGFR, ERBB2, FABP4, FLT3, GRM1, GRM5, HTR2A, HTR2B, IGF1R, MIF, SRC 3.11656
[BP] GO:0006936 None ADRA1A, DRD1, DRD2, HTR2A, HTR2B, HTR7, TRPV1 3.11032
[BP] GO:0044070 regulation of anion transport ADORA1, CA2, CA7, GRM5, MIF 3.10554
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ADRA1A, ADRB1, AURKB, DRD1, DRD2, DRD3, EGFR, ERBB2, F3, FLT3, GRM1, GRM5, HTR2A, HTR2B, IGF1R, KDR, MET, MIF, MMP9, MTNR1A, PPARA, SRC, TRPV1, XDH 3.09994
[BP] GO:0040011 locomotion AXL, CYP1B1, DRD1, DRD2, EGFR, FUT7, HTR2B, HTR6, KDR, MET, MIF, MMP1, MMP9, SRC 3.07936
[BP] GO:0060134 None DRD1, DRD2, DRD3 3.0601
[BP] GO:0032230 positive regulation of synaptic transmission, GABAergic ADRA1A, CA2, CA7 3.0601
[BP] GO:0001997 None ADRA1A, ADRB1 3.04065
[BP] GO:0055114 oxidation-reduction process AKR1B1, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, HSD17B2, MAOA, NQO2, TBXAS1, TYR, XDH 3.02772
[BP] GO:0008217 None ADORA1, ADRA1A, ADRB1, DRD2, DRD3, PPARA 2.98393
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, DRD1, DRD2, DRD3, EGFR 2.97302
[BP] GO:0051580 None DRD1, DRD2, DRD3 2.96678
[BP] GO:0051967 None ADORA1, DRD2, HTR2A 2.96678
[BP] GO:2001023 None DRD1, DRD2, DRD3, HTR2A, MET 2.95089
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, ERBB2, F3, MET, SRC 2.94199
[BP] GO:0010038 response to metal ion CA2, CYP1A1, CYP1A2, DRD2, EGFR, FABP4, MMP9, PTGES 2.94082
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ADRA1A, DRD2, EGFR, ERBB2, FLT3, GRM1, GRM5, HTR2A, HTR2B, KDR, MIF, MMP9, SRC, XDH 2.93713
[BP] GO:0051588 None DRD1, DRD2, DRD3, GRIK5, HTR1A 2.93302
[BP] GO:0048870 cell motility AXL, CYP1B1, DRD1, DRD2, EGFR, FUT7, HTR2B, HTR6, KDR, MIF, MMP1, MMP9, SRC 2.93217
[BP] GO:0050730 None ADORA1, EGFR, FLT3, GRM5, HTR2A, MIF, SRC 2.92604
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, DRD1, DRD2, DRD3, EGFR, F3, FABP4, KDR, MET, MIF, PPARA 2.92551
[BP] GO:0001101 response to acid chemical AKR1B1, EGFR, FABP3, HSD17B2, KDR, MMP2, PTGES, SRC 2.92294
[BP] GO:0050708 None ACHE, CACNA1C, DRD2, DRD3, EGFR, HTR2B, MIF, MTNR1B, SRC 2.92214
[BP] GO:0030818 None DRD2, DRD3, GRM3, GRM8 2.92061
[BP] GO:0050789 regulation of biological process ACHE, ADORA1, ADORA3, ADRA1A, ADRB1, AKR1B1, AURKB, AXL, CA1, CA2, CA7, CACNA1C, CDK6, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, EGFR, ERBB2, F3, FABP3, FABP4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, MIF, MMP1, MMP2, MMP9, MTNR1A, MTNR1B, PIM1, PPARA, PTGES, SIGMAR1, SLC1A1, SRC, TRPV1, XDH 2.90746
[BP] GO:0048583 regulation of response to stimulus ADORA1, ADRA1A, ADRB1, AKR1B1, AURKB, AXL, CDK6, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, ERBB2, F3, FABP4, FLT3, GRM1, HTR2A, HTR2B, HTR6, IGF1R, KDR, MET, MIF, MMP2, MMP9, PPARA, SRC, XDH 2.9024
[BP] GO:0050961 None ADORA1, HTR2A, TRPV1 2.89644
[BP] GO:0050965 None ADORA1, HTR2A, TRPV1 2.89644
[BP] GO:0001963 None DRD1, DRD2, DRD3 2.89644
[BP] GO:0051283 None DRD2, HTR2A, HTR2B, TRPV1 2.891
[BP] GO:0051209 None DRD2, HTR2A, HTR2B, TRPV1 2.891
[BP] GO:0008016 None ADORA1, ADORA3, ADRA1A, ADRB1, CACNA1C, DRD2, SLC1A1 2.87235
[BP] GO:0006468 protein phosphorylation AURKB, AXL, CDK6, DRD1, EGFR, ERBB2, FLT3, HTR2B, IGF1R, KDR, MET, PIM1, SRC 2.85937
[BP] GO:0030803 None DRD2, DRD3, GRM3, GRM8 2.85671
[BP] GO:0050794 regulation of cellular process ACHE, ADORA1, ADORA3, ADRA1A, ADRB1, AKR1B1, AURKB, AXL, CA1, CA2, CA7, CACNA1C, CDK6, CYP19A1, CYP1A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, EGFR, ERBB2, F3, FABP3, FABP4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, MIF, MMP1, MMP2, MMP9, MTNR1A, MTNR1B, PIM1, PPARA, PTGES, SIGMAR1, SRC, TRPV1, XDH 2.8339
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, KDR, SRC 2.82327
[BP] GO:0071071 None FABP3, HTR2A, HTR2B 2.82222
[BP] GO:0032225 None DRD1, DRD2, DRD3 2.82222
[BP] GO:0002027 None ADRA1A, ADRB1, CACNA1C, DRD2, SLC1A1 2.80946
[BP] GO:0044093 positive regulation of molecular function ADORA1, ADRA1A, ADRB1, AURKB, DRD2, EGFR, ERBB2, F3, FLT3, GRM1, GRM5, HTR2A, HTR2B, MET, MIF, MMP9, SRC, XDH 2.80459
[BP] GO:0090087 None ACHE, ADORA1, CA2, CACNA1C, DRD2, DRD3, EGFR, ERBB2, HTR2B, MIF, MTNR1B, SRC 2.80107
[BP] GO:0030815 None DRD2, DRD3, GRM3, GRM8 2.79723
[BP] GO:0008202 steroid metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, HSD17B2 2.77579
[BP] GO:1900372 None DRD2, DRD3, GRM3, GRM8 2.76737
[BP] GO:0030809 None DRD2, DRD3, GRM3, GRM8 2.76737
[BP] GO:0010518 positive regulation of phospholipase activity ADRA1A, EGFR, HTR2A, HTR2B 2.76737
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, ADRA1A, ADRB1, AURKB, DRD2, EGFR, ERBB2, F3, FLT3, GRM1, GRM5, HTR2A, HTR2B, MIF, SRC, XDH 2.76737
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ADRA1A, ADRB1, AURKB, DRD1, DRD2, DRD3, EGFR, ERBB2, F3, FABP3, FLT3, GRM1, GRM5, HTR2A, HTR2B, IGF1R, KDR, MET, MIF, MMP9, MTNR1A, PPARA, SRC, TRPV1, XDH 2.74275
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HTR2A, MET, SRC 2.74275
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HTR2A, MET, SRC 2.74275
[BP] GO:0030260 entry into host cell AXL, EGFR, HTR2A, MET, SRC 2.74275
[BP] GO:0044409 entry into host AXL, EGFR, HTR2A, MET, SRC 2.74275
[BP] GO:0030800 None DRD2, DRD3, GRM3, GRM8 2.74049
[BP] GO:0031399 regulation of protein modification process ADORA1, ADRA1A, DRD1, DRD2, EGFR, ERBB2, FABP4, FLT3, GRM1, GRM5, HTR2A, HTR2B, IGF1R, KDR, MIF, MMP9, SRC, XDH 2.7378
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, CYP1A1, CYP1B1, DRD1, EGFR, FLT3, SRC, TRPV1 2.70396
[BP] GO:0002793 None ACHE, ADORA1, DRD2, EGFR, HTR2B, MIF, SRC 2.70396
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, ADRA1A, DRD1, DRD2, DRD3, EGFR, ERBB2, HTR2A, IGF1R, MET, MIF, MMP9, SRC, XDH 2.69194
[BP] GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation ADORA1, FLT3, GRM5, HTR2A, MIF, SRC 2.68918
[BP] GO:0014821 None DRD1, DRD2, HTR2B 2.68918
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, ADRA1A, DRD1, DRD2, DRD3, EGFR, ERBB2, HTR2A, IGF1R, MET, MIF, MMP9, SRC, XDH 2.68005
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, CYP1B1, EGFR, MMP9, SRC 2.67866
[BP] GO:0044236 multicellular organism metabolic process ADRB1, MMP1, MMP2, MMP9, TRPV1 2.65423
[BP] GO:0099566 None GRM1, GRM5 2.65423
[BP] GO:0001996 None ADRA1A, ADRB1 2.65423
[BP] GO:0060160 None DRD2, DRD3 2.65423
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.65423
[BP] GO:0003099 None ADRA1A, ADRB1 2.65423
[BP] GO:0006721 terpenoid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2D6, EGFR 2.6443
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, ADRA1A, ADRB1, AKR1B1, AURKB, AXL, CDK6, CYP19A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, EGFR, ERBB2, FABP3, FABP4, GRM3, GRM8, HTR2A, HTR2B, IGF1R, KDR, MET, MIF, MMP9, PIM1, PPARA, PTGES, SRC, TRPV1, XDH 2.63709
[BP] GO:0045187 None ADORA1, DRD2, DRD3 2.63511
[BP] GO:0016048 None ADORA1, HTR2A, TRPV1 2.63511
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B2 2.63325
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, EGFR, HTR2B, IGF1R, KDR, MIF, MMP9, PIM1, SRC 2.62963
[BP] GO:0051234 None ACHE, ADORA1, ADRA1A, ALOX5, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CACNA1C, DRD1, DRD2, DRD3, EGFR, FABP3, GRIA2, GRIA4, GRIK5, HTR2A, HTR2B, MIF, MMP9, PPARA, SIGMAR1, SLC1A1, SRC, TRPV1, XDH 2.61859
[BP] GO:0019752 carboxylic acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, MIF, PIM1, PPARA, PTGES, TBXAS1, TYR 2.61234
[BP] GO:0031623 None ACHE, DRD2, DRD3, HTR2B 2.60978
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ADRA1A, CDK6, CYP19A1, DRD1, DRD2, DRD3, EGFR, ERBB2, IGF1R, MET, MIF, MMP9, PPARA, SRC, XDH 2.57621
[BP] GO:0035813 None ADORA1, DRD2, DRD3 2.57621
[BP] GO:0071880 None ADRA1A, ADRB1, DRD2 2.57621
[BP] GO:0044092 negative regulation of molecular function ADORA3, AURKB, CYP1B1, CYP2D6, DRD2, DRD3, FABP4, GRM3, IGF1R, MET, MMP9, PIM1, PPARA, SRC 2.56636
[BP] GO:0050890 None ADORA1, DRD1, DRD2, DRD3, EGFR, GRM5, HTR2A 2.56318
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B2 2.56197
[BP] GO:0097553 None DRD2, HTR2A, HTR2B, TRPV1 2.55756
[BP] GO:0019722 calcium-mediated signaling CACNA1C, EGFR, GRM5, HTR2B, KDR 2.55415
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2D6, NQO2 2.53699
[BP] GO:0042749 None ADORA1, DRD2, DRD3 2.52068
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.52068
[BP] GO:0010517 regulation of phospholipase activity ADRA1A, EGFR, HTR2A, HTR2B 2.50403
[BP] GO:0032102 negative regulation of response to external stimulus ADORA1, CYP19A1, DRD1, DRD2, DRD3, MIF, PPARA 2.50261
[BP] GO:0050877 None ADORA1, CYP1B1, DRD1, DRD2, DRD3, EGFR, GRM1, GRM5, GRM8, HTR2A, TRPV1, TYR 2.46933
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AXL, CYP1B1, EGFR, MMP9, SRC 2.4586
[BP] GO:0048015 phosphatidylinositol-mediated signaling ERBB2, HTR2A, HTR2B, IGF1R 2.45252
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, ADRA1A, DRD2, EGFR, ERBB2, F3, FLT3, GRM1, GRM5, HTR2A, HTR2B, KDR, MIF, MMP9, SRC, XDH 2.44086
[BP] GO:0060193 positive regulation of lipase activity ADRA1A, EGFR, HTR2A, HTR2B 2.42805
[BP] GO:0006810 None ACHE, ADORA1, ADRA1A, ALOX5, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CACNA1C, DRD1, DRD2, DRD3, FABP3, GRIA2, GRIA4, GRIK5, HTR2A, HTR2B, MIF, MMP9, PPARA, SIGMAR1, SLC1A1, SRC, TRPV1, XDH 2.42432
[BP] GO:0044062 None ADORA1, DRD2, DRD3 2.41237
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.41237
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, DRD1, EGFR, GRM5, IGF1R, MMP2, SRC, TRPV1 2.4038
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.40224
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.40224
[BP] GO:0048017 inositol lipid-mediated signaling ERBB2, HTR2A, HTR2B, IGF1R 2.38476
[BP] GO:0006720 isoprenoid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2D6, EGFR 2.37086
[BP] GO:1902532 negative regulation of intracellular signal transduction ADRA1A, DRD2, DRD3, IGF1R, MET, MIF, MMP9, SRC, XDH 2.37013
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B2 2.37013
[BP] GO:0010460 None ADRA1A, ADRB1, SLC1A1 2.37013
[BP] GO:0071875 None ADRA1A, ADRB1, DRD2 2.37013
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.37013
[BP] GO:0009966 regulation of signal transduction ADORA1, ADRA1A, ADRB1, AKR1B1, AURKB, AXL, CYP1B1, DRD2, DRD3, EGFR, ERBB2, F3, FLT3, GRM1, HTR2A, HTR2B, HTR6, IGF1R, KDR, MET, MIF, MMP9, SRC, XDH 2.33904
[BP] GO:0015908 None DRD2, DRD3, FABP3, PPARA 2.31846
[BP] GO:0051179 None ACHE, ADORA1, ADRA1A, ALOX5, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CACNA1C, DRD1, DRD2, DRD3, EGFR, FABP3, GRIA2, GRIA4, GRIK5, HTR2A, HTR2B, MIF, MMP9, PPARA, SIGMAR1, SLC1A1, SRC, TRPV1, XDH 2.30219
[BP] GO:0035235 None GRIA2, GRIA4, GRIK5 2.27197
[BP] GO:0001975 None DRD1, DRD2, DRD3 2.27197
[BP] GO:0043436 oxoacid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, MIF, PIM1, PPARA, PTGES, TBXAS1, TYR 2.25154
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, MMP2, MMP9, SRC 2.21058
[BP] GO:0021853 None DRD1, DRD2 2.20765
[BP] GO:0010641 None F3, SRC 2.20765
[BP] GO:0090325 None DRD2, DRD3 2.20765
[BP] GO:0071502 None HTR2B, TRPV1 2.20765
[BP] GO:1904936 None DRD1, DRD2 2.20765
[BP] GO:0042321 None ADORA1, DRD2 2.20765
[BP] GO:0010513 None HTR2A, HTR2B 2.20765
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, DRD1, EGFR, GRM5, IGF1R, MMP2, SRC, TRPV1 2.19389
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ADRA1A, DRD2, EGFR, ERBB2, F3, FLT3, GRM1, GRM5, HTR2A, HTR2B, KDR, MIF, MMP9, SRC, XDH 2.19389
[BP] GO:0006082 organic acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, MIF, PIM1, PPARA, PTGES, TBXAS1, TYR 2.19029
[BP] GO:0014059 None DRD2, DRD3, HTR2A 2.18712
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, DRD1, EGFR, ERBB2, FLT3, GRM5, IGF1R, MMP2, SRC, TRPV1 2.17577
[BP] GO:0030534 None DRD1, DRD2, DRD3, HTR2A, PPARA 2.16879
[BP] GO:0009891 positive regulation of biosynthetic process ADRB1, AURKB, DRD1, DRD2, DRD3, EGFR, ERBB2, FABP3, HTR2A, HTR2B, IGF1R, KDR, MET, MTNR1A, PPARA, SRC, TRPV1 2.16767
[BP] GO:0043271 negative regulation of ion transport ADORA1, DRD2, DRD3, HTR2A, MMP9 2.15629
[BP] GO:0050808 None ACHE, DRD1, DRD2, ERBB2, GRM5 2.12962
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9 2.1296
[BP] GO:0046717 None DRD2, DRD3, SLC1A1, TRPV1 2.1091
[BP] GO:0030335 positive regulation of cell migration DRD1, EGFR, F3, IGF1R, KDR, MET, MMP9, SRC 2.1091
[BP] GO:0050678 None CDK6, EGFR, ERBB2, F3, HTR2B, KDR, XDH 2.1071
[BP] GO:0042743 hydrogen peroxide metabolic process CYP1A1, CYP1A2, EGFR 2.1071
[BP] GO:0009056 catabolic process ACHE, ADORA1, AURKB, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, FABP4, FUT7, MAOA, MMP1, MMP2, MMP9, SRC, XDH 2.10414
[BP] GO:0008285 negative regulation of cell proliferation ADORA1, ADORA3, ADRA1A, CDK6, CYP1B1, DRD2, ERBB2, FABP3, PTGES, XDH 2.0858
[BP] GO:0016310 phosphorylation AURKB, AXL, CDK6, DRD1, EGFR, ERBB2, FLT3, HTR2B, IGF1R, KDR, MET, PIM1, SRC 2.07897
[BP] GO:0071248 cellular response to metal ion CYP1A1, CYP1A2, EGFR, FABP4, MMP9 2.06986
[BP] GO:0071276 cellular response to cadmium ion CYP1A2, EGFR, MMP9 2.06986
[BP] GO:0045744 None DRD2, DRD3, MET 2.06986
[BP] GO:0050714 None ACHE, DRD2, EGFR, HTR2B, MIF, SRC 2.06536
[BP] GO:0007611 None DRD1, DRD2, DRD3, EGFR, GRM5, HTR2A 2.06536
[BP] GO:0010760 negative regulation of macrophage chemotaxis CYP19A1, MIF 2.0621
[BP] GO:0021843 None DRD1, DRD2 2.0621
[BP] GO:0021830 None DRD1, DRD2 2.0621
[BP] GO:0003057 None ADRA1A, ADRB1 2.0621
[BP] GO:0021826 None DRD1, DRD2 2.0621
[BP] GO:0016098 monoterpenoid metabolic process CYP1A2, CYP2D6 2.0621
[BP] GO:0009266 None ADORA1, ADRB1, HTR2A, HTR2B, TRPV1 2.05306
[BP] GO:0007194 None DRD2, DRD3, GRM3 2.04159
[BP] GO:0098801 None ADORA1, DRD2, DRD3 2.04159
[BP] GO:0042596 None ADRB1, DRD1, HTR1A 2.04159
[BP] GO:0033273 response to vitamin ALPL, CYP1A1, EGFR, TYR 2.02792
[BP] GO:2000147 positive regulation of cell motility DRD1, EGFR, F3, IGF1R, KDR, MET, MMP9, SRC 2.02792
[BP] GO:0006816 None ADRA1A, CACNA1C, DRD2, HTR2A, HTR2B, TRPV1 2.02132
[BP] GO:0045907 None ADRA1A, EGFR, HTR2A 2.00598
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, ADRA1A, ADRB1, AXL, CA4, DRD1, DRD2, DRD3, F3, FLT3, GRIA2, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, MTNR1A, MTNR1B, SIGMAR1, SLC1A1, TRPV1 12.3162
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, ADRA1A, ADRB1, AXL, CA2, CA4, CACNA1C, DRD1, DRD2, DRD3, EGFR, ERBB2, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, MTNR1A, MTNR1B, SIGMAR1, SLC1A1, SRC, TRPV1 11.1526
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, ADRA1A, ADRB1, AXL, DRD1, DRD2, DRD3, FLT3, GRIA2, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, MTNR1A, MTNR1B, SIGMAR1, SLC1A1, TRPV1 10.9308
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, ADRA1A, ADRB1, ALPL, AXL, CA12, CA14, CA2, CA4, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, EGFR, ERBB2, F3, FLT3, FUT7, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSD17B2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MAOA, MET, MTNR1A, MTNR1B, PTGES, SIGMAR1, SLC1A1, SRC, TBXAS1, TRPV1, TYR 8.6751
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ADRA1A, ADRB1, ALPL, AXL, CA12, CA14, CA2, CA4, CACNA1C, DRD1, DRD2, DRD3, EGFR, ERBB2, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, MMP2, MTNR1A, MTNR1B, PIM1, SLC1A1, SRC, TRPV1 8.3086
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ADRA1A, ADRB1, ALOX5, ALPL, AXL, CA12, CA14, CA2, CA4, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, EGFR, ERBB2, F3, FLT3, FUT7, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSD17B2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MAOA, MET, MMP2, MTNR1A, MTNR1B, PIM1, PTGES, SIGMAR1, SLC1A1, SRC, TBXAS1, TRPV1, TYR 8.22852
[CC] GO:0098590 plasma membrane region ADORA1, ADRA1A, CA2, CA4, DRD1, DRD2, EGFR, ERBB2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR2A, MET, SIGMAR1, SLC1A1, SRC, TRPV1 8.15362
[CC] GO:0031224 None ACHE, ADORA1, ADORA3, ADRA1A, ADRB1, ALPL, AXL, CA12, CA14, CA4, CACNA1C, DRD1, DRD2, DRD3, EGFR, ERBB2, F3, FLT3, FUT7, GRIA2, GRM1, GRM3, GRM5, GRM8, HSD17B2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MAOA, MET, MTNR1A, MTNR1B, PTGES, SIGMAR1, SLC1A1, TBXAS1, TRPV1, TYR 6.87566
[CC] GO:0016021 None ADORA1, ADORA3, ADRA1A, ADRB1, ALPL, AXL, CA12, CA14, CACNA1C, DRD1, DRD2, DRD3, EGFR, ERBB2, F3, FLT3, FUT7, GRIA2, GRM1, GRM3, GRM5, GRM8, HSD17B2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MAOA, MET, MTNR1A, MTNR1B, PTGES, SIGMAR1, SLC1A1, TBXAS1, TRPV1, TYR 5.94657
[CC] GO:0014069 None ADORA1, CACNA1C, DRD2, GRIK5, GRM1, GRM3, GRM5, SIGMAR1, SRC 5.23147
[CC] GO:0099572 None ADORA1, CACNA1C, DRD2, GRIK5, GRM1, GRM3, GRM5, SIGMAR1, SRC 5.23147
[CC] GO:0044456 None ACHE, ADORA1, CACNA1C, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, SIGMAR1, SRC, TRPV1 4.73714
[CC] GO:0097060 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, SIGMAR1, TRPV1 4.09444
[CC] GO:0042995 cell projection ADORA1, AKR1B1, CA2, CDK6, DRD1, DRD2, DRD3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR2B, HTR5A, HTR6, SRC 3.99777
[CC] GO:0120025 None ADORA1, AKR1B1, CA2, CDK6, DRD1, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR2B, HTR5A, HTR6, SRC 3.69668
[CC] GO:0042734 None GRIK5, GRM1, GRM3, GRM5, GRM8 3.60847
[CC] GO:0043005 None ADORA1, CA2, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR2B, HTR5A, SRC 3.51239
[CC] GO:0097458 None ADORA1, CA2, CACNA1C, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR2A, HTR2B, HTR5A, SIGMAR1, SRC, TRPV1 3.37482
[CC] GO:0043235 receptor complex EGFR, ERBB2, GRIA2, GRIA4, GRIK5, GRM1, IGF1R, MTNR1A 2.92294
[CC] GO:0043197 None ADORA1, DRD2, GRIA2, GRIA4, GRM3 2.47116
[CC] GO:0044309 None ADORA1, DRD2, GRIA2, GRIA4, GRM3 2.44086
[CC] GO:0044463 None ADORA1, AKR1B1, CA4, DRD1, DRD2, GRIA2, GRIA4, GRIK5, GRM3, HTR2A, SIGMAR1, SRC, TRPV1 2.41237
[CC] GO:0120038 None ADORA1, AKR1B1, CA4, DRD1, DRD2, GRIA2, GRIA4, GRIK5, GRM3, HTR2A, SIGMAR1, SRC, TRPV1 2.41237
[CC] GO:0005789 endoplasmic reticulum membrane CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, EGFR, GRIA2, HSD17B2, PTGES, SIGMAR1, TBXAS1 2.37013
[CC] GO:0045211 None GRIA2, GRIA4, GRIK5, GRM3, SIGMAR1, TRPV1 2.28646
[CC] GO:0098794 None ADORA1, DRD2, GRIA2, GRIA4, GRM3 2.03098
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, ADRA1A, ADRB1, AXL, DRD1, DRD2, DRD3, EGFR, ERBB2, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, MTNR1A, MTNR1B, SIGMAR1, TRPV1 15.7685
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, ADRA1A, ADRB1, AXL, DRD1, DRD2, DRD3, EGFR, ERBB2, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, MTNR1A, MTNR1B, SIGMAR1, TRPV1 15.7685
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, ADRA1A, ADRB1, AXL, DRD1, DRD2, DRD3, EGFR, ERBB2, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, MTNR1A, MTNR1B, PPARA, SIGMAR1, TRPV1 15.7685
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, ADRA1A, ADRB1, AXL, CDK6, DRD1, DRD2, DRD3, EGFR, ERBB2, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, MTNR1A, MTNR1B, PPARA, SIGMAR1, TRPV1 14.9023
[MF] GO:0004872 receptor activity ADORA1, ADORA3, ADRA1A, ADRB1, AXL, DRD1, DRD2, DRD3, EGFR, ERBB2, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, MTNR1A, MTNR1B, PPARA, SIGMAR1, TRPV1 14.3752
[MF] GO:0030594 None DRD1, DRD2, DRD3, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 14.3129
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, ADRA1A, ADRB1, AXL, DRD1, DRD2, DRD3, EGFR, ERBB2, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, MTNR1A, MTNR1B, PPARA, SIGMAR1, TRPV1 13.2946
[MF] GO:0008227 None ADRA1A, ADRB1, DRD2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 9.31587
[MF] GO:0070405 ammonium ion binding ACHE, DRD1, DRD2, DRD3, HTR1A, HTR2A, HTR2B, HTR5A, HTR7 8.42986
[MF] GO:0008066 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 8.42986
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7 8.25904
[MF] GO:0004930 None ADORA1, ADORA3, ADRA1A, ADRB1, DRD1, DRD2, DRD3, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, MTNR1A, MTNR1B, SIGMAR1 8.15058
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CDK6, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, EGFR, ERBB2, FLT3, HTR2A, HTR2B, IGF1R, KDR, MET, NQO2, PIM1, PPARA, SIGMAR1, SRC, TRPV1 7.59774
[MF] GO:0043167 ion binding ACHE, ALOX5, ALPL, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CACNA1C, CDK6, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, EGFR, ERBB2, F3, FABP3, FABP4, FLT3, HTR1A, HTR2A, HTR2B, HTR5A, HTR7, IGF1R, KDR, MET, MMP1, MMP2, MMP9, NQO2, PIM1, PPARA, PTGES, SLC1A1, SRC, TBXAS1, TRPV1, TYR, XDH 7.51619
[MF] GO:0004993 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 7.10555
[MF] GO:0099589 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 7.10555
[MF] GO:0043176 None HTR1A, HTR2A, HTR2B, HTR5A, HTR7 7.09251
[MF] GO:0051378 None HTR1A, HTR2A, HTR2B, HTR5A, HTR7 7.09251
[MF] GO:0046914 transition metal ion binding ALOX5, CA1, CA12, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, MMP1, MMP2, MMP9, NQO2, PIM1, PPARA, TBXAS1, TYR, XDH 6.85774
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, ERBB2, FLT3, IGF1R, KDR, MET 6.22343
[MF] GO:0099528 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 5.97555
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, ERBB2, FLT3, IGF1R, KDR, MET 5.58516
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6 5.48412
[MF] GO:0042165 neurotransmitter binding ACHE, HTR1A, HTR2A, HTR2B, HTR5A, HTR7 5.26437
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6 5.2423
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7 5.14149
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, TBXAS1, TYR 5.11201
[MF] GO:0005506 iron ion binding ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, TBXAS1, XDH 4.8108
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, HTR1A, HTR2A, HTR2B, HTR5A, HTR7, MMP1, MMP2, MMP9, NQO2, PIM1, PPARA, SLC1A1, TBXAS1, TRPV1, TYR, XDH 4.68386
[MF] GO:0004713 protein tyrosine kinase activity AXL, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, SRC 4.4794
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7 4.44955
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, SRC, TBXAS1 4.35078
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6 4.20488
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, SRC, TBXAS1 4.17481
[MF] GO:1901338 None ADRB1, DRD1, DRD2, DRD3 4.11446
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, TBXAS1, TYR 3.89562
[MF] GO:0016491 oxidoreductase activity AKR1B1, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, HSD17B2, MAOA, NQO2, TBXAS1, TYR, XDH 3.86136
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, ALOX5, ALPL, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CDK6, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, EGFR, ERBB2, F3, FLT3, FUT7, HSD17B2, IGF1R, KDR, MAOA, MET, MIF, MMP1, MMP2, MMP9, NQO2, PIM1, PTGES, SRC, TBXAS1, TYR, XDH 3.71633
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, ERBB2, KDR 3.50951
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, NQO2, PTGES, SRC, TBXAS1, XDH 3.26053
[MF] GO:0004952 None DRD1, DRD2, DRD3 3.15465
[MF] GO:0035240 None DRD1, DRD2, DRD3 3.0601
[MF] GO:0042562 hormone binding ACHE, EGFR, IGF1R, MTNR1A, NQO2 3.03961
[MF] GO:0004672 protein kinase activity AURKB, AXL, CDK6, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, PIM1, SRC 2.93217
[MF] GO:0004935 None ADRA1A, ADRB1, DRD2 2.82222
[MF] GO:0005231 None GRIA2, GRIA4, GRIK5, TRPV1 2.79723
[MF] GO:0008502 None MTNR1A, MTNR1B 2.65423
[MF] GO:0099583 None GRM1, GRM5 2.65423
[MF] GO:0004970 None GRIA2, GRIA4, GRIK5 2.63511
[MF] GO:0005234 None GRIA2, GRIA4, GRIK5 2.63511
[MF] GO:0009055 electron transfer activity AKR1B1, CYP19A1, CYP1A2, NQO2, XDH 2.63325
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7 2.57163
[MF] GO:0004971 None GRIA2, GRIA4 2.40224
[MF] GO:0099094 None GRIA2, GRIA4, GRIK5, TRPV1 2.36689
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CDK6, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, PIM1, SRC 2.33771
[MF] GO:0005230 None GRIA2, GRIA4, GRIK5, TRPV1 2.14995
[MF] GO:0004064 arylesterase activity CA1, CA2 2.0621
[MF] GO:0016301 kinase activity AURKB, AXL, CDK6, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, PIM1, SRC 2.04447
[MF] GO:0003676 nucleic acid binding EGFR, PPARA 2.8478


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 GRIA2, GRIK5, HTR2B, HTR1A, ADRB1, TRPV1, HTR2A, HTR5A, ADRA1A, GRM1, GRM3, HTR6, GRM5, MTNR1A, HTR7, MTNR1B, ADORA3, GRM8, ADORA1, DRD1, DRD2, DRD3, GRIA4 23.3262
Calcium signaling pathway_Homo sapiens_hsa04020 HTR2B, ADRB1, CACNA1C, HTR2A, HTR5A, ADRA1A, GRM1, EGFR, HTR6, GRM5, HTR7, ERBB2, DRD1 11.6182
Serotonergic synapse_Homo sapiens_hsa04726 HTR6, HTR7, MAOA, CYP2D6, ALOX5, HTR2B, HTR1A, CACNA1C, HTR2A, HTR5A 9.6692
Gap junction_Homo sapiens_hsa04540 GRM5, SRC, HTR2B, ADRB1, HTR2A, DRD1, DRD2, GRM1, EGFR 9.3311
Glutamatergic synapse_Homo sapiens_hsa04724 GRM3, GRIA2, GRM5, GRIK5, GRM8, SLC1A1, CACNA1C, GRM1, GRIA4 8.3855
cAMP signaling pathway_Homo sapiens_hsa04024 GRIA2, HTR6, ADORA1, HTR1A, ADRB1, CACNA1C, DRD1, DRD2, PPARA, GRIA4 7.5611
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA14 9.3311
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, ERBB2, MMP9, EGFR 7.0416
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 6.5549
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, ERBB2, KDR, MMP9, MET, EGFR, IGF1R 5.249
Dopaminergic synapse_Homo sapiens_hsa04728 GRIA2, MAOA, CACNA1C, DRD1, DRD2, DRD3, GRIA4 5.4013
Pathways in cancer_Homo sapiens_hsa05200 CDK6, FLT3, MMP1, MMP2, ERBB2, MMP9, MET, EGFR, IGF1R 4.1618
Cocaine addiction_Homo sapiens_hsa05030 GRM3, GRIA2, MAOA, DRD1, DRD2 5.0984
Amphetamine addiction_Homo sapiens_hsa05031 GRIA2, MAOA, CACNA1C, DRD1, GRIA4 4.4814
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 4.7627
Adherens junction_Homo sapiens_hsa04520 SRC, ERBB2, MET, EGFR, IGF1R 4.2971
Circadian entrainment_Homo sapiens_hsa04713 GRIA2, MTNR1A, MTNR1B, CACNA1C, GRIA4 3.8444
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, GRM1, EGFR 3.7809
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 GRIA2, GRM5, CACNA1C, GRM1, GRIA4 3.761
Focal adhesion_Homo sapiens_hsa04510 SRC, ERBB2, KDR, MET, EGFR, IGF1R 3.3626
MicroRNAs in cancer_Homo sapiens_hsa05206 CDK6, ERBB2, PIM1, CYP1B1, MMP9, MET, EGFR 3.3626
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KDR, DRD2, MET, EGFR, IGF1R 3.3283
Tryptophan metabolism_Homo sapiens_hsa00380 MAOA, CYP1A2, CYP1A1, CYP1B1 4.0642
Long-term potentiation_Homo sapiens_hsa04720 GRIA2, GRM5, CACNA1C, GRM1 3.3283
Metabolic pathways_Homo sapiens_hsa01100 MAOA, AKR1B1, TYR, CYP19A1, FUT7, ALOX5, TBXAS1, HSD17B2, CYP1A2, CYP1A1, ALPL, XDH, PTGES 2.9682
Phospholipase D signaling pathway_Homo sapiens_hsa04072 GRM3, GRM5, GRM8, GRM1, EGFR 3.2027
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, ERBB2, MET, EGFR 3.3283
Melanoma_Homo sapiens_hsa05218 CDK6, MET, EGFR, IGF1R 3.2729
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, ADRB1, MET, EGFR, IGF1R 2.9682
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1, ADRB1, CACNA1C, ADRA1A 2.9682
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CYP2D6, CYP1A2, CYP1A1, CYP1B1 3.2503
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.305
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC, HTR2B, TRPV1, HTR2A 2.8573
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, CACNA1C, EGFR 2.9682
Ras signaling pathway_Homo sapiens_hsa04014 HTR7, KDR, MET, EGFR, IGF1R 2.4112
Non-small cell lung cancer_Homo sapiens_hsa05223 CDK6, ERBB2, EGFR 2.4595
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1, ADRB1 2.4595
Glioma_Homo sapiens_hsa05214 CDK6, EGFR, IGF1R 2.3252
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CDK6, KDR, MET, EGFR, IGF1R 1.8069
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 2.0391
Long-term depression_Homo sapiens_hsa04730 GRIA2, GRM1, IGF1R 2.3945
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, PIM1, F3 1.8804
Pancreatic cancer_Homo sapiens_hsa05212 CDK6, ERBB2, EGFR 2.3191
Taste transduction_Homo sapiens_hsa04742 HTR1A, CACNA1C, GRM1 2.0867
Renin secretion_Homo sapiens_hsa04924 ADORA1, ADRB1, CACNA1C 2.3344
ErbB signaling pathway_Homo sapiens_hsa04012 SRC, ERBB2, EGFR 2.0391
Prostate cancer_Homo sapiens_hsa05215 ERBB2, EGFR, IGF1R 2.0262
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, TBXAS1, PTGES 2.3639
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 1.5105
HIF-1 signaling pathway_Homo sapiens_hsa04066 ERBB2, EGFR, IGF1R 1.8645
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 2.2979
Hepatitis B_Homo sapiens_hsa05161 CDK6, SRC, MMP9 1.4954
FoxO signaling pathway_Homo sapiens_hsa04068 GRM1, EGFR, IGF1R 1.583
Chemical carcinogenesis_Homo sapiens_hsa05204 CYP1A2, CYP1A1, CYP1B1 2.0922
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 MAOA, CYP2D6, CYP1A2 2.289
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 ADRB1, CACNA1C, ADRA1A 1.4874
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, CACNA1C, EGFR 1.4259
Alcoholism_Homo sapiens_hsa05034 MAOA, DRD1, DRD2 1.304
Tyrosine metabolism_Homo sapiens_hsa00350 MAOA, MIF, TYR 2.9759
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, CACNA1C 0.9714
Platelet activation_Homo sapiens_hsa04611 SRC, TBXAS1 0.9223
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, ADORA1 0.9292
Parkinson's disease_Homo sapiens_hsa05012 DRD1, DRD2 0.8324
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.9307
Hepatitis C_Homo sapiens_hsa05160 PPARA, EGFR 0.8681
Vascular smooth muscle contraction_Homo sapiens_hsa04270 CACNA1C, ADRA1A 0.9292
AMPK signaling pathway_Homo sapiens_hsa04152 ADRA1A, IGF1R 0.9154
Morphine addiction_Homo sapiens_hsa05032 ADORA1, DRD1 1.1144
GABAergic synapse_Homo sapiens_hsa04727 SRC, CACNA1C 1.1224
Salivary secretion_Homo sapiens_hsa04970 ADRB1, ADRA1A 1.1197
Dilated cardiomyopathy_Homo sapiens_hsa05414 ADRB1, CACNA1C 1.117
Viral carcinogenesis_Homo sapiens_hsa05203 CDK6, SRC 0.6317
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC, EGFR 0.616
MAPK signaling pathway_Homo sapiens_hsa04010 CACNA1C, EGFR 0.5345
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.2121
Huntington's disease_Homo sapiens_hsa05016 GRM5 0.3157
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3355
Tuberculosis_Homo sapiens_hsa05152 SRC 0.3349
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.3225
Alzheimer's disease_Homo sapiens_hsa05010 CACNA1C 0.3473
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1 0.3641
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.3759
Tight junction_Homo sapiens_hsa04530 SRC 0.3975
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 IGF1R 0.3934
Measles_Homo sapiens_hsa05162 CDK6 0.4018
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4272
Cell cycle_Homo sapiens_hsa04110 CDK6 0.4272
Axon guidance_Homo sapiens_hsa04360 MET 0.4222
Insulin resistance_Homo sapiens_hsa04931 PPARA 0.4564
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC 0.4381
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.3916
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.4564
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5 0.4381
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 IGF1R 0.4812
Melanogenesis_Homo sapiens_hsa04916 TYR 0.4806
Choline metabolism in cancer_Homo sapiens_hsa05231 EGFR 0.4806
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4806
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.4859
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4856
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4852
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1 1.3464
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.4337
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.4984
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.4995
Insulin secretion_Homo sapiens_hsa04911 CACNA1C 0.505
Aldosterone synthesis and secretion_Homo sapiens_hsa04925 CACNA1C 0.5117
Small cell lung cancer_Homo sapiens_hsa05222 CDK6 0.5043
Chronic myeloid leukemia_Homo sapiens_hsa05220 CDK6 0.5345
Protein digestion and absorption_Homo sapiens_hsa04974 SLC1A1 0.4984
Endometrial cancer_Homo sapiens_hsa05213 ERBB2, EGFR 1.4954
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC 0.5345
Peroxisome_Homo sapiens_hsa04146 XDH 0.5102
Cardiac muscle contraction_Homo sapiens_hsa04260 CACNA1C 0.5183
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5345
Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 CACNA1C 0.5102
Complement and coagulation cascades_Homo sapiens_hsa04610 F3 0.5174
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5345
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5458
Bile secretion_Homo sapiens_hsa04976 CA2 0.5345
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.5345
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.5491
Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 CACNA1C 0.5345
Shigellosis_Homo sapiens_hsa05131 SRC 0.5474
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B1 0.5766
Malaria_Homo sapiens_hsa05144 MET 0.6317
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 GRIA2 0.6253
Arginine and proline metabolism_Homo sapiens_hsa00330 MAOA 0.6287
Type II diabetes mellitus_Homo sapiens_hsa04930 CACNA1C 0.6317
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.6436
Nicotine addiction_Homo sapiens_hsa05033 GRIA2, GRIA4 1.6851
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 MAOA 0.6953
Galactose metabolism_Homo sapiens_hsa00052 AKR1B1 0.7934
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.8271
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7849
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B1 0.7333
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B1 0.7768
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.8024
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8324
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8271
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.0922
Histidine metabolism_Homo sapiens_hsa00340 MAOA 0.8551
Phenylalanine metabolism_Homo sapiens_hsa00360 MAOA, MIF 2.3191
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.0368
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.2503


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)