Prescription Description
| Prescription ID | TCMF5332 |
| Pinyin Name | Wan Ling Jin Gu Gao |
| Chinese Name | 万灵筋骨膏 |
| English Name | Wan Ling Jin Gu Ointment |
| Function Description | 痹病 |
| Indications | Arthritis, Rheumatoid arthritis |
| Disease ICD-11 Category |
FA2Z [Inflammatory arthropathies, unspecified, 炎性关节病，未特指的
]; FA20 [Rheumatoid arthritis, 类风湿性关节炎 ]; |
| Human Tissues Associated with Indication | SkeletalMuscle, Blood |
| Reference | CFDA |
| Reference Book/link | http://samr.cfda.gov.cn/WS01/CL0001/ |
Prescription Components
| Component ID | Latin Name | Chinese Name | Component Quantity | Barcode |
|---|---|---|---|---|
| TCMH296 | Radix aconiti | 川乌 | TCMH296 | |
| TCMH222 | Aconitum carmichaelii | 草乌 | TCMH222 | ITSAH2410-14 |
| TCMH517 | Angelica pubescens | 独活 | TCMH517 | ITSAF170-14 |
| TCMH1665 | Notopterygium incisum | 羌活 | TCMH1665 | JF755946 |
| TCMH1398 | Ephedra sinica | 麻黄 | TCMH1398 | ITSAM882-14 |
| TCMH562 | Saposhnikovia divaricata | 防风 | TCMH562 | ITSAE3225-14 |
| TCMH421 | Angelica sinensis | 当归 | TCMH421 | ITSAF173-14 |
| TCMH544 | Curcuma aeruginosa | 莪术 | TCMH544 | ITSAN2146-14 |
| TCMH1766 | Sparganium stoloniferum | 三棱 | TCMH1766 | ITSAJ4240-14 |
| TCMH2265 | Cyperus rotundus | 香附 | TCMH2265 | GENG1049-15 |
| TCMH2129 | Eupolyphaga sinensis | 土鳖虫 | TCMH2129 | GBMIN33972-13 |
| TCMH1511 | Momordica cochinchinensis | 木鳖子 | TCMH1511 | ITSAJ4256-14 |
| TCMH168 | Ricinus communis | 蓖麻子 | TCMH168 | ITSAB3015-14 |
| TCMH363 | Rheum officinale | 大黄 | TCMH363 | ITSAJ4685-14 |
| TCMH2175 | Galla chinensis | 五倍子 | TCMH2175 | |
| TCMH1662 | Pharbitis nil | 牵牛子 | TCMH1662 | |
| TCMH857 | Radix knoxiae | 红大戟 | TCMH857 | |
| TCMH2378 | Daphne genkwa | 芫花 | TCMH2378 | |
| TCMH661 | Euphorbia kansui | 甘遂 | TCMH661 | |
| TCMH28 | Croton tiglium | 巴豆 | TCMH28 | ITSAJ4152-14 |
| TCMH2693 | Fructus gleditsiae abnormalis | 猪牙皂 | TCMH2693 | |
| TCMH1315 | Salix babylonica | 柳枝 | TCMH1315 | GBVJ4838-11, GBVJ4840-11 |
| TCMH1742 | Cinnamomum cassia | 肉桂 | TCMH1742 | GQ255631 |
Targeted Human Proteins by the Ingredients of Prescription
| Target ID | Gene Symbol | Target Name | Target Class | Uniprot ID |
|---|---|---|---|---|
| TCMT100 | TTR | Transthyretin | Unclassified | P02766 |
| TCMT102 | ACP1 | Low molecular weight phosphotyrosine protein phosphatase | Hydrolase | P24666 |
| TCMT103 | PTPRF | Receptor-type tyrosine-protein phosphatase F (LAR) | Hydrolase | P10586 |
| TCMT112 | ADORA3 | Adenosine A3 receptor | GPCR | P0DMS8 |
| TCMT114 | CNR2 | Cannabinoid CB2 receptor | GPCR | P34972 |
| TCMT115 | CNR1 | Cannabinoid CB1 receptor | GPCR | P21554 |
| TCMT127 | PARP1 | Poly [ADP-ribose] polymerase-1 | Transferase | P09874 |
| TCMT130 | ALOX5 | Arachidonate 5-lipoxygenase | Oxidoreductase | P09917 |
| TCMT131 | ACHE | Acetylcholinesterase | Hydrolase | P22303 |
| TCMT133 | CA1 | Carbonic anhydrase I | Lyase | P00915 |
Showing 1 to 10 of 137 entries
Targeted Pathogenic Microbes by the Ingredients of Prescription
| Target ID | Target Name |
|---|---|
| TCMT1170 | Enterobacter cloacae |
| TCMT1175 | Human immunodeficiency virus |
| TCMT1176 | Streptococcus pneumoniae |
| TCMT1178 | Actinomyces viscosus |
| TCMT1180 | Human herpesvirus 2 |
| TCMT1181 | Mycobacterium tuberculosis H37Ra |
| TCMT1182 | Streptococcus sanguinis |
| TCMT1183 | Candida albicans SC5314 |
| TCMT1189 | Pseudomonas fluorescens |
| TCMT1190 | Plasmodium falciparum (isolate FcB1 / Columbia) |
Showing 1 to 10 of 66 entries
Gene Ontology Associated to Targeted Human Proteins
| GO Term | GO Name | Enriched Genes | Log10 Adjusted P-value |
|---|---|---|---|
| [BP] GO:0000302 | response to reactive oxygen species | AKR1B1, AXL, BCL2, CYP1B1, EGFR, MMP9, PRKCD, SRC | 3.92253 |
| [BP] GO:0001101 | response to acid chemical | AKR1B1, EGFR, FABP3, HSD17B2, KDR, MMP2, PRKCE, PTGS2, SRC | 2.96622 |
| [BP] GO:0001503 | ossification | ALOX15, ALPL, BCL2, EGFR, MMP2, MMP9, TEK | 4.06939 |
| [BP] GO:0001505 | regulation of neurotransmitter levels | ACHE, CYP1B1, EGFR, HTR1A, INSR, PTGS2, SMAD3 | 2.12991 |
| [BP] GO:0001516 | None | MIF, PTGS1, PTGS2 | 2.84902 |
| [BP] GO:0001525 | angiogenesis | CYP1B1, KDR, MMP2, PIK3CA, PIK3CB, PRKCA, PTGS2, TEK | 2.8603 |
| [BP] GO:0001666 | response to hypoxia | ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PRKCB, PRKCE, PTGS2, SMAD3, SRC, TEK | 6.35492 |
| [BP] GO:0001676 | long-chain fatty acid metabolic process | ALOX15, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2, TBXAS1 | 6.77885 |
| [BP] GO:0001775 | cell activation | ALOX5, APP, AXL, BCL2, EGFR, FLT3, FUT7, HSPA1A, MIF, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, RORC, SMAD3, SRC | 5.75001 |
| [BP] GO:0001932 | regulation of protein phosphorylation | ADORA1, ALOX15, APP, BCL2, DUSP3, EGFR, FABP4, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MIF, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, SRC, TEK, XDH | 6.42622 |
Showing 1 to 10 of 583 entries
KEGG Pathways Associated to Targeted Human Proteins
| KEGG Pathway ID | Enriched Genes | Log10 Adjusted P-value |
|---|---|---|
| Acute myeloid leukemia_Homo sapiens_hsa05221 | PIK3CA, FLT3, PIM1, PIK3CB | 3.4115 |
| Adherens junction_Homo sapiens_hsa04520 | SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R | 6.5774 |
| Adipocytokine signaling pathway_Homo sapiens_hsa04920 | PPARA | 0.5272 |
| Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | PIK3CA, BCL2, PRKCA, PIK3CB | 2.145 |
| African trypanosomiasis_Homo sapiens_hsa05143 | PRKCG, PRKCB, PRKCA | 2.9179 |
| AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | SMAD3, PIK3CA, PRKCB, MMP2, PRKCE, PRKCD, BCL2, PIM1, PRKCA, PIK3CB | 9.2714 |
| Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | PRKCG, PRKCB, PRKCE, PRKCA | 2.9378 |
| Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | PRKCG, HSD11B2, PIK3CA, PRKCB, INSR, PRKCA, PIK3CB | 8.2779 |
| Alzheimer's disease_Homo sapiens_hsa05010 | APP | 0.2709 |
| Amoebiasis_Homo sapiens_hsa05146 | PRKCG, PIK3CA, PRKCB, PRKCA, PIK3CB | 3.5408 |
Showing 1 to 10 of 172 entries
Target Exprsssion in Healthy Human Tissues (protein & mRNA level)
Protein expression data was from the "Human Proteome Map" datasetmRNA expression data was from the "GTEx" dataset
Average Target Expression (Fold Change) in Multiple Disease Conditions
Fold Change with Corresponding Normal SamplesClick each cell within the heatmap to access gene expression of individual patient samples