TCM Prescription: Wan Ling Jin Gu Ointment



Prescription Description
Prescription IDTCMF5332
Pinyin NameWan Ling Jin Gu Gao
Chinese Name万灵筋骨膏
English NameWan Ling Jin Gu Ointment
Function Description痹病
IndicationsArthritis, Rheumatoid arthritis
Disease ICD-11 Category FA2Z [Inflammatory arthropathies, unspecified, 炎性关节病，未特指的 ];
FA20 [Rheumatoid arthritis, 类风湿性关节炎 ];
Human Tissues Associated with IndicationSkeletalMuscle, Blood
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH296 Radix aconiti 川乌 TCMH296
TCMH222 Aconitum carmichaelii 草乌 TCMH222 ITSAH2410-14
TCMH517 Angelica pubescens 独活 TCMH517 ITSAF170-14
TCMH1665 Notopterygium incisum 羌活 TCMH1665 JF755946
TCMH1398 Ephedra sinica 麻黄 TCMH1398 ITSAM882-14
TCMH562 Saposhnikovia divaricata 防风 TCMH562 ITSAE3225-14
TCMH421 Angelica sinensis 当归 TCMH421 ITSAF173-14
TCMH544 Curcuma aeruginosa 莪术 TCMH544 ITSAN2146-14
TCMH1766 Sparganium stoloniferum 三棱 TCMH1766 ITSAJ4240-14
TCMH2265 Cyperus rotundus 香附 TCMH2265 GENG1049-15
TCMH2129 Eupolyphaga sinensis 土鳖虫 TCMH2129 GBMIN33972-13
TCMH1511 Momordica cochinchinensis 木鳖子 TCMH1511 ITSAJ4256-14
TCMH168 Ricinus communis 蓖麻子 TCMH168 ITSAB3015-14
TCMH363 Rheum officinale 大黄 TCMH363 ITSAJ4685-14
TCMH2175 Galla chinensis 五倍子 TCMH2175
TCMH1662 Pharbitis nil 牵牛子 TCMH1662
TCMH857 Radix knoxiae 红大戟 TCMH857
TCMH2378 Daphne genkwa 芫花 TCMH2378
TCMH661 Euphorbia kansui 甘遂 TCMH661
TCMH28 Croton tiglium 巴豆 TCMH28 ITSAJ4152-14
TCMH2693 Fructus gleditsiae abnormalis 猪牙皂 TCMH2693
TCMH1315 Salix babylonica 柳枝 TCMH1315 GBVJ4838-11, GBVJ4840-11
TCMH1742 Cinnamomum cassia 肉桂 TCMH1742 GQ255631
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT114 CNR2 Cannabinoid CB2 receptor GPCR P34972
TCMT115 CNR1 Cannabinoid CB1 receptor GPCR P21554
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT151 PRKCA Protein kinase C alpha Kinase P17252
TCMT152 PRKCB Protein kinase C beta Kinase P05771
TCMT153 PRKCG Protein kinase C gamma Kinase P05129
TCMT154 PRKCD Protein kinase C delta Kinase Q05655
TCMT155 PRKCE Protein kinase C epsilon Kinase Q02156
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT160 HTR7 Serotonin 7 (5-HT7) receptor GPCR P34969
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT17 POLB DNA polymerase beta Transferase P06746
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT226 PDPK1 3-phosphoinositide dependent protein kinase-1 Kinase O15530
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT289 TBXAS1 Thromboxane-A synthase Isomerase P24557
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT313 HTR2B Serotonin 2b (5-HT2b) receptor GPCR P41595
TCMT314 HTR2C Serotonin 2c (5-HT2c) receptor GPCR P28335
TCMT315 HTR6 Serotonin 6 (5-HT6) receptor GPCR P50406
TCMT318 HKDC1 Putative hexokinase HKDC1 Transferase Q2TB90
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT337 XPO1 Exportin-1 Unclassified O14980
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT36 HTR1A Serotonin 1a (5-HT1a) receptor GPCR P08908
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT37 HTR2A Serotonin 2a (5-HT2a) receptor GPCR P28223
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT508 SYK Tyrosine-protein kinase SYK Kinase P43405
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT61 MCL1 Induced myeloid leukemia cell differentiation protein Mcl-1 Unclassified Q07820
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT636 POLA1 DNA polymerase alpha subunit Transferase P09884
TCMT645 HTR1E Serotonin 1e (5-HT1e) receptor GPCR P28566
TCMT646 HTR5A Serotonin 5a (5-HT5a) receptor GPCR P47898
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT678 XIAP Inhibitor of apoptosis protein 3 Transferase P98170
TCMT679 MPEG1 Macrophage-expressed gene 1 protein Unclassified Q2M385
TCMT680 KAT2B Histone acetyltransferase PCAF Transferase Q92831
TCMT683 MIF Macrophage migration inhibitory factor Isomerase P14174
TCMT689 TGM2 Protein-glutamine gamma-glutamyltransferase Transferase P21980
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT718 TXN2 Thioredoxin, mitochondrial Unclassified Q99757
TCMT719 TXN Thioredoxin Unclassified P10599
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT729 PIK3CA PI3-kinase p110-alpha subunit Transferase P42336
TCMT730 PIK3CB PI3-kinase p110-beta subunit Transferase P42338
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT815 HTR1D Serotonin 1d (5-HT1d) receptor GPCR P28221
TCMT816 HTR1B Serotonin 1b (5-HT1b) receptor GPCR P28222
TCMT817 HTR4 Serotonin 4 (5-HT4) receptor GPCR Q13639
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1180 Human herpesvirus 2
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1183 Candida albicans SC5314
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1201 Staphylococcus epidermidis ATCC 12228
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1230 Human herpesvirus 5
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1284 Penicillium expansum
TCMT1285 Human coxsackievirus B3
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CA12, CA2, CA7, CNR1, CNR2, CYP19A1, CYP1A1, CYP1B1, CYP3A4, EGFR, ESR1, FABP3, FABP4, FLT3, GPR35, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR4, HTR7, INSR, KDR, MCL1, MET, MIF, PIK3CA, PIK3CB, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PTGS1, PTGS2, SMAD3, SRC, TEK, XDH 17.2012
[BP] GO:0007210 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 16.079
[BP] GO:0098664 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 16.079
[BP] GO:0042221 response to chemical AKR1B1, ALOX15, ALPL, APP, AXL, BCL2, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, HSPA1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR5A, IGF1R, INSR, KDR, MCL1, MMP2, MMP9, PIK3CA, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, RORC, SMAD3, SRC, TEK, TYR 16.079
[BP] GO:0010033 response to organic substance AKR1B1, ALOX15, ALPL, APP, AXL, BCL2, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, HSPA1A, HTR1B, HTR5A, IGF1R, INSR, KDR, MCL1, MMP2, PIK3CA, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, RORC, SMAD3, SRC, TEK, TYR 15.4231
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, FLT3, GPR35, HCAR2, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, INSR, KDR, MCL1, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, SMAD3, SRC, TEK, XDH 13.9189
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, FLT3, GPR35, HCAR2, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, INSR, KDR, MCL1, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, SMAD3, SRC, TEK, XDH 13.8891
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APP, AXL, BCL2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP3, HSD11B2, HSD17B2, HTR1B, HTR5A, IGF1R, INSR, MMP2, MMP9, PIK3CA, POLB, PPARA, PRKCB, PRKCD, PRKCE, PTGS2, RORC, SRC, TEK, TYR 13.7786
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, APP, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, EGFR, ESR1, FABP3, FABP4, FUT7, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MET, MIF, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, TBXAS1 12.7181
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, APP, AXL, BCL2, CYP1B1, EGFR, FLT3, GPR35, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, INSR, KDR, MCL1, MET, MIF, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCE, PTGS2, SRC, TEK, XDH 12.4211
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, FLT3, GPR35, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, MCL1, MET, MIF, MMP9, NUAK1, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, SRC, TEK, XDH 11.8174
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, ALOX15, APP, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, FLT3, GPR35, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, INSR, KDR, MCL1, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, SMAD3, SRC, TEK, XDH 11.7371
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 11.2443
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX15, ALOX5, APP, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, FABP3, FUT7, HSPA1A, HTR2B, HTR2C, MIF, PIK3CA, PIM1, PPARA, PTGS1, PTGS2, TBXAS1, TYR, XDH 11.0343
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CA2, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, FLT3, GPR35, HCAR2, HSPA1A, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, MCL1, MET, MIF, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, SMAD3, SRC, TEK, XDH 10.9913
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, ALPL, APP, AURKB, AXL, BCL2, CA2, CA6, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, HSPA1A, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR5A, IGF1R, INSR, KDR, MCL1, MIF, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, RORC, SMAD3, SRC, TEK, TYR 10.9472
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CA2, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, FLT3, GPR35, HCAR2, HSPA1A, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, MCL1, MET, MIF, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, SMAD3, SRC, TEK, XDH 10.815
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.4015
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, ALOX15, APP, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, EGFR, FABP4, FLT3, GPR35, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, INSR, KDR, MCL1, MET, MIF, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, SMAD3, SRC, TEK, XDH 10.3537
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, EGFR, ESR1, FABP3, FLT3, HSD11B2, HSD17B2, HTR1B, HTR5A, PRKCE, PTGS2, RORC, SRC, TYR 10.0141
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CNR1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, EGFR, ESR1, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR1A, HTR2A, HTR2C, PRKCA, PRKCE 9.99735
[BP] GO:0014070 response to organic cyclic compound ALPL, APP, BCL2, CA2, CA9, CNR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FLT3, HSD11B2, HTR1B, HTR5A, PRKCE, PRKCG, PTGS2, RORC, SRC, TEK, TYR 9.97573
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, HCAR2, HSPA1A, HTR2B, IGF1R, KDR, MCL1, MET, MIF, MMP9, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCD, PRKCG, PTGS2, SMAD3, SRC, TEK, XDH 9.43613
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, APP, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, FABP3, FLT3, HSPA1A, HTR1A, HTR1B, HTR2A, HTR2B, IGF1R, INSR, KDR, MIF, MMP12, MMP2, MMP9, NUAK1, PIM1, PRKCA, PTGS1, PTGS2, SMAD3, SRC, TEK, XDH 9.40362
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, HCAR2, HSPA1A, HTR2B, IGF1R, KDR, MCL1, MET, MIF, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCD, PRKCG, PTGS2, SMAD3, SRC, TEK, XDH 9.37871
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APP, AXL, BCL2, CNR1, CNR2, CYP19A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, FABP4, HSD11B2, HSD17B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR7, IGF1R, INSR, MCL1, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIM1, PPARA, PRKCD, PRKCG, PTGS2, RORC, SMAD3, SRC, TEK, TYR 9.35928
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, MIF, PTGS1, PTGS2, TBXAS1 9.35793
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, HSPA1A, HTR2B, IGF1R, KDR, MCL1, MET, MIF, MMP9, PIK3CA, PIM1, PPARA, PRKCA, PRKCD, PRKCG, PTGS2, SMAD3, SRC, TEK 9.35793
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, HSPA1A, HTR2B, IGF1R, KDR, MCL1, MET, MIF, MMP9, PIK3CA, PIM1, PRKCA, PRKCD, PRKCG, PTGS2, SMAD3, SRC, TEK 9.32961
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, ALOX15, APP, AXL, BCL2, CA2, CA7, CNR1, CSNK2A1, CYP19A1, CYP1B1, EGFR, GPR35, HCAR2, HSPA1A, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, PIK3CB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, SMAD3, SRC, TEK 9.29242
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, APP, AXL, BCL2, CA12, CA2, CA7, CNR1, EGFR, ESR1, FABP3, FABP4, FLT3, GPR35, HTR2A, HTR2B, HTR2C, INSR, MCL1, MET, PIK3CA, PIK3CB, POLA1, POLB, PRKCB, PRKCE, SMAD3, SRC 9.14981
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 9.09901
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, FABP3, FLT3, HSD11B2, HTR1B, HTR5A, IGF1R, INSR, MMP2, PPARA, PRKCD, PRKCE, PTGS2, SMAD3, SRC, TEK 9.09901
[BP] GO:0006690 icosanoid metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, MIF, PTGS1, PTGS2, TBXAS1 9.08811
[BP] GO:0042493 response to drug AKR1B1, AXL, BCL2, CA9, CNR1, CNR2, CYP1A1, CYP1B1, EGFR, FABP3, HSD11B2, HTR1B, HTR2A, HTR2B, HTR2C, KDR, POLB, PRKCD, PRKCE, PRKCG, PTGS2, SRC 9.04598
[BP] GO:0009725 response to hormone AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, FABP3, FLT3, HSD11B2, HTR1B, HTR5A, INSR, PPARA, PRKCD, PRKCE, PTGS2, SRC, TEK 9.03835
[BP] GO:0019369 arachidonic acid metabolic process ALOX15, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2, TBXAS1 8.90617
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, HCAR2, HSPA1A, HTR2B, IGF1R, KDR, MCL1, MIF, MMP9, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCD, PRKCG, PTGS2, SMAD3, SRC, TEK, XDH 8.90617
[BP] GO:0051049 regulation of transport ACHE, ADORA1, ALOX15, APP, AXL, BCL2, CA2, CA7, CNR1, CYP19A1, EGFR, GPR35, HCAR2, HSPA1A, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, INSR, MIF, MMP12, MMP9, PIK3CB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, SMAD3, SRC 8.81646
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, HSPA1A, HTR2B, IGF1R, KDR, MCL1, MIF, MMP9, PIK3CA, PIM1, PRKCA, PRKCD, PRKCG, PTGS2, SMAD3, SRC, TEK 8.69142
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 8.50932
[BP] GO:0097756 None ADORA1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 8.48657
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CA2, CA7, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, FABP3, FLT3, GPR35, HCAR2, HSPA1A, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, MCL1, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, RORC, SMAD3, SRC, TEK, XDH 8.44515
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CNR1, CYP1A1, FABP3, FLT3, HCAR2, HTR2A, HTR2B, HTR2C, PPARA, PRKCD, PRKCE, PTGS2, RORC, SRC, TEK 8.42293
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, PPARA, PRKCD, PRKCE, PTGS2, SRC, TEK 8.37842
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, PRKCD, SRC, TEK 8.17578
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ALOX15, APP, BCL2, DUSP3, EGFR, FABP3, FABP4, FLT3, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MIF, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PTGS2, SMAD3, SRC, TEK, XDH 8.17578
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ALOX15, APP, BCL2, DUSP3, EGFR, FABP3, FABP4, FLT3, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MIF, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PTGS2, SMAD3, SRC, TEK, XDH 8.09941
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, BCL2, CA2, CA7, CNR1, EGFR, HCAR2, HTR2A, HTR2B, HTR2C, KDR, MIF, PIK3CB, PRKCE, PTGS2, SRC 7.74029
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX15, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, EGFR, FABP3, FABP4, FUT7, MET, MIF, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, TBXAS1 7.73738
[BP] GO:0048583 regulation of response to stimulus ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, FABP4, FLT3, GPR35, HSPA1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, MCL1, MET, MIF, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, SMAD3, SRC, TEK, XDH 7.6926
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALOX15, ALPL, APP, AXL, BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP4, FLT3, HSPA1A, HTR1B, IGF1R, INSR, KDR, MMP2, MMP9, PIK3CA, PRKCB, PRKCD, PRKCE, PTGS2, RORC, SMAD3, SRC 7.65569
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, ALPL, APP, AURKB, AXL, BCL2, CSNK2A1, DUSP3, EGFR, FLT3, HSPA1A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, POLB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, SRC, TEK, XDH 7.60235
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ALOX15, APP, DUSP3, EGFR, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MIF, PIK3CB, PRKCA, PRKCD, PRKCE, SRC, TEK, XDH 7.60235
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DUSP3, EGFR, ESR1, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR1B, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, RORC, SMAD3, SRC, TBXAS1, TEK, TYR, XDH 7.51994
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7, CNR1, CNR2, HTR1B, PRKCE 7.50406
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, BCL2, CA2, CYP1A1, EGFR, HSD11B2, HSPA1A, HTR1B, HTR2A, HTR2B, MMP2, POLB, PPARA, PRKCB, PRKCE, PTGS2, SMAD3, SRC, TEK, TYR 7.44954
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ALOX15, APP, BCL2, EGFR, FABP3, FLT3, HTR2A, HTR2B, HTR2C, INSR, KDR, MIF, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, SMAD3, SRC, TEK, XDH 7.44954
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ALOX15, APP, BCL2, EGFR, FABP3, FLT3, HTR2A, HTR2B, HTR2C, INSR, KDR, MIF, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, SMAD3, SRC, TEK, XDH 7.44954
[BP] GO:1901568 fatty acid derivative metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, MIF, PTGS1, PTGS2, TBXAS1 7.42571
[BP] GO:0003018 None ADORA1, EGFR, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2, SRC, TEK 7.42571
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, APP, AXL, BCL2, CA1, CA2, CNR1, CNR2, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, GPR35, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MCL1, MET, MIF, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, RORC, SMAD3, SRC, TEK 7.4159
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALOX15, ALPL, APP, AXL, BCL2, CYP1A1, CYP1B1, EGFR, ESR1, FABP4, FLT3, HTR1B, IGF1R, INSR, KDR, MMP2, PIK3CA, PRKCB, PRKCD, PRKCE, PTGS2, RORC, SMAD3, SRC 7.36667
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ALOX15, APP, EGFR, FLT3, HTR2A, HTR2B, HTR2C, INSR, KDR, MIF, PIK3CB, PRKCA, PRKCE, SRC, TEK, XDH 7.35189
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, BCL2, CSNK2A1, EGFR, FLT3, HTR2B, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK 7.26955
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APP, CNR1, CNR2, EGFR, FABP3, FLT3, HSD11B2, HTR1B, IGF1R, INSR, MMP2, PPARA, PRKCD, PRKCE, PRKCG, PTGS2, SRC, TEK, TYR 7.24444
[BP] GO:0048878 chemical homeostasis AKR1B1, APP, BCL2, CA12, CA2, CA7, CNR1, EGFR, ESR1, FABP3, FABP4, GPR35, HTR2A, HTR2B, HTR2C, INSR, MET, PIK3CA, PIK3CB, PRKCB, PRKCE, SMAD3 7.20902
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ALOX15, APP, BCL2, EGFR, FLT3, HTR2A, HTR2B, HTR2C, INSR, KDR, MIF, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, SRC, TEK, XDH 7.19624
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, ALPL, APP, AURKB, AXL, BCL2, CSNK2A1, DUSP3, EGFR, FLT3, HSPA1A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, POLB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, SRC, TEK, XDH 7.19314
[BP] GO:0080134 regulation of response to stress ADORA1, APP, CNR1, CNR2, CYP19A1, DUSP3, EGFR, ESR1, FABP4, HSPA1A, IGF1R, MCL1, MET, MIF, MMP12, MMP2, NUAK1, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, SMAD3, SRC, TEK, XDH 7.18506
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CA2, CA7, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, FABP3, FABP4, FLT3, GPR35, HCAR2, HSPA1A, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, MCL1, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, RORC, SMAD3, SRC, TEK, XDH 7.16359
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, KDR, MMP9, PRKCD, PTGS2, SRC 7.0965
[BP] GO:0007198 None HTR1A, HTR1B, HTR5A, HTR7 7.03913
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, BCL2, CNR1, CNR2, CYP1A1, CYP1B1, HTR1B, HTR1D, KDR, POLB, PRKCD, PRKCE, SRC 6.98583
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALOX15, ALPL, APP, AURKB, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP4, FLT3, HSPA1A, HTR1B, IGF1R, INSR, KDR, MCL1, MIF, MMP2, MMP9, NUAK1, PIK3CA, POLA1, POLB, PRKCB, PRKCD, PRKCE, PTGS2, RORC, SMAD3, SRC 6.9778
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CSNK2A1, EGFR, ESR1, FLT3, HTR1A, HTR1B, HTR2A, HTR2B, IGF1R, INSR, KDR, MIF, MMP12, MMP2, MMP9, PIM1, PRKCA, PTGS2, TEK 6.97572
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ALOX15, APP, BCL2, EGFR, FLT3, HTR2A, HTR2B, HTR2C, INSR, KDR, MIF, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, SRC, TEK, XDH 6.89692
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2, NQO2, PTGS1, PTGS2, TBXAS1, TYR, XDH 6.89077
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, FLT3, GPR35, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, MCL1, MET, MIF, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, SMAD3, SRC, TEK, XDH 6.87771
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CA9, CNR2, CYP1A1, CYP1A2, CYP1B1, EGFR, HSD11B2, HSPA1A, HTR1A, HTR2C, MCL1, MIF, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, POLA1, POLB, PPARA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, SMAD3, SRC, TEK 6.81359
[BP] GO:0007187 None ADORA1, CNR1, CNR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR4, HTR5A, HTR6, HTR7 6.786
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, POLB, PPARA, PRKCB, PRKCE, PTGS2, SMAD3, SRC, TEK 6.77885
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX15, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2, TBXAS1 6.77885
[BP] GO:1901698 response to nitrogen compound AKR1B1, APP, CNR1, CNR2, EGFR, FABP3, FLT3, HSD11B2, HTR1B, IGF1R, INSR, MMP2, PPARA, PRKCD, PRKCE, PRKCG, PTGS2, SRC, TEK, TYR 6.77879
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DUSP3, EGFR, ESR1, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR1B, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP2, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, RORC, SMAD3, SRC, TBXAS1, TEK, TYR, XDH 6.77465
[BP] GO:0009894 regulation of catabolic process ADORA1, BCL2, CNR1, CSNK2A1, EGFR, HCAR2, HSPA1A, HTR2A, HTR2B, INSR, KDR, MCL1, MET, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, SMAD3 6.77465
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 6.7678
[BP] GO:0006631 fatty acid metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, MIF, PPARA, PTGS1, PTGS2, TBXAS1 6.7159
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, PRKCD, SRC, TEK 6.59485
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, PIM1, PRKCG, SRC, TEK 6.51584
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade ALOX15, APP, EGFR, HTR2A, HTR2B, HTR2C, KDR, MIF, PRKCA, SRC, TEK 6.49582
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, BCL2, CSNK2A1, EGFR, FLT3, HTR2B, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK 6.49142
[BP] GO:0030168 platelet activation AXL, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC 6.45847
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APP, BCL2, CYP19A1, CYP1B1, EGFR, IGF1R, INSR, KDR, MET, MIF, MMP9, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TEK 6.44642
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ALOX15, APP, BCL2, DUSP3, EGFR, FABP4, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MIF, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, SRC, TEK, XDH 6.42622
[BP] GO:0042325 regulation of phosphorylation ADORA1, ALOX15, APP, BCL2, DUSP3, EGFR, FABP4, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MIF, MMP9, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PTGS2, SRC, TEK, XDH 6.35556
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PRKCB, PRKCE, PTGS2, SMAD3, SRC, TEK 6.35492
[BP] GO:0003013 None ADORA1, EGFR, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2, SRC, TEK 6.34251
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA1, ADORA3, APP, CA2, CNR1, CNR2, ESR1, GPR35, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, INSR, PIK3CA, PIK3CB, SRC 6.31353
[BP] GO:0009895 negative regulation of catabolic process ADORA1, BCL2, CNR1, EGFR, HCAR2, HTR2B, MCL1, MET, PIK3CA, PPARA, PRKCG, SMAD3 6.29208
[BP] GO:0042310 None HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7 6.24761
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APP, BCL2, CYP19A1, CYP1B1, EGFR, HTR1D, IGF1R, INSR, KDR, MET, MIF, MMP9, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TEK 6.2451
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PRKCB, PRKCE, PTGS2, SMAD3, SRC, TEK 6.22722
[BP] GO:0031399 regulation of protein modification process ADORA1, ALOX15, APP, BCL2, DUSP3, EGFR, FABP4, FLT3, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MIF, MMP9, NUAK1, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, SRC, TEK, XDH 6.21824
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX15, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MIF, PIK3CA, PIK3CB, PTGS1, PTGS2 6.13816
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ALOX15, APP, DUSP3, EGFR, HTR2A, HTR2B, HTR2C, KDR, MIF, PRKCA, SRC, TEK 6.10973
[BP] GO:0097746 None ADORA1, EGFR, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 6.04466
[BP] GO:0035296 None ADORA1, EGFR, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 6.04466
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APP, BCL2, CYP19A1, CYP1B1, EGFR, IGF1R, INSR, KDR, MET, MIF, MMP9, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TEK 6.04181
[BP] GO:0008283 cell proliferation ACHE, AURKB, BCL2, CYP1A1, EGFR, ESR1, FLT3, HTR1A, MET, MIF, PIK3CB, PIM1, POLA1, PRKCD, SRC, TEK, TYR 5.95484
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALOX15, ALPL, APP, AURKB, AXL, BCL2, CA2, CA9, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, FABP4, FLT3, FUT7, HSD11B1, HSD17B2, HTR2A, HTR2B, HTR5A, INSR, KDR, MCL1, MET, MIF, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, POLB, PPARA, PRKCA, PRKCD, PTGS2, RORC, SMAD3, SRC, TEK, TYR 5.89964
[BP] GO:0050880 None ADORA1, EGFR, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 5.825
[BP] GO:0035150 None ADORA1, EGFR, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 5.79894
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ALOX15, APP, BCL2, CSNK2A1, EGFR, ESR1, FLT3, HSPA1A, HTR2A, HTR2B, HTR2C, INSR, KDR, MIF, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, SMAD3, SRC, TEK, XDH 5.75702
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2 5.75001
[BP] GO:0001775 cell activation ALOX5, APP, AXL, BCL2, EGFR, FLT3, FUT7, HSPA1A, MIF, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, RORC, SMAD3, SRC 5.75001
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, BCL2, CNR2, DUSP3, EGFR, ESR1, GPR35, HSPA1A, HTR1B, HTR2A, IGF1R, MCL1, MET, MIF, MMP12, MMP9, PRKCB, PRKCD, PTGS2, SMAD3, SRC, XDH 5.70103
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, APP, CA2, CA7, CNR1, CNR2, EGFR, HTR1B, HTR2A, PRKCE, PTGS2 5.70103
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, APP, CA2, CA7, CNR1, CNR2, EGFR, HTR1B, HTR2A, PRKCE, PTGS2 5.70103
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, PRKCD, SRC, TEK 5.6887
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, BCL2, CNR2, DUSP3, EGFR, ESR1, GPR35, HSPA1A, HTR1B, HTR2A, IGF1R, MCL1, MET, MIF, MMP12, MMP9, PRKCB, PRKCD, PTGS2, SMAD3, SRC, XDH 5.68483
[BP] GO:0030335 positive regulation of cell migration APP, BCL2, EGFR, IGF1R, INSR, KDR, MET, MMP9, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TEK 5.6805
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CNR1, CNR2, CYP19A1, EGFR, ESR1, FABP4, KDR, MET, MIF, MMP12, PPARA, PRKCA, PRKCD, PRKCG, PTGS2, SMAD3, TEK 5.63886
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ESR1, FLT3, HSD11B1, HSD17B2, INSR, KDR, PIK3CA, POLB, PPARA, SMAD3, SRC, TEK, TYR 5.63886
[BP] GO:0018212 peptidyl-tyrosine modification AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, PRKCD, SRC, TEK 5.63886
[BP] GO:0035556 intracellular signal transduction AKR1B1, AXL, BCL2, CYP1B1, EGFR, HTR2A, HTR2B, HTR5A, IGF1R, INSR, KDR, MCL1, MET, MIF, NUAK1, PIK3CA, PIK3CB, POLB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK 5.63886
[BP] GO:0050795 None ADORA1, CNR1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B 5.63267
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, ALOX15, APP, BCL2, EGFR, ESR1, FLT3, HSPA1A, HTR2A, HTR2B, HTR2C, INSR, KDR, MIF, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, SMAD3, SRC, TEK, XDH 5.62313
[BP] GO:0043271 negative regulation of ion transport ADORA1, BCL2, CNR1, GPR35, HTR1B, HTR2A, MMP9, PRKCE, PTGS2 5.62313
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, APP, AURKB, BCL2, CNR1, CNR2, CSNK2A1, DUSP3, EGFR, ESR1, FABP4, FLT3, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, MIF, MMP9, NUAK1, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, SMAD3, SRC, TEK, XDH 5.61027
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APP, BCL2, CYP19A1, CYP1B1, EGFR, IGF1R, INSR, KDR, MET, MIF, MMP9, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TEK 5.53554
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ALOX15, APP, BCL2, EGFR, FLT3, HTR2A, HTR2B, HTR2C, INSR, KDR, MIF, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, SRC, TEK, XDH 5.51665
[BP] GO:2000147 positive regulation of cell motility APP, BCL2, EGFR, IGF1R, INSR, KDR, MET, MMP9, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TEK 5.51665
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, APP, AURKB, AXL, BCL2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, FABP3, FABP4, GPR35, HSPA1A, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MCL1, MET, MIF, MMP12, MMP9, PIK3CA, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, RORC, SMAD3, SRC, TEK, XDH 5.51455
[BP] GO:0051272 positive regulation of cellular component movement APP, BCL2, EGFR, IGF1R, INSR, KDR, MET, MMP9, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TEK 5.37222
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.35576
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B1, HSD17B2 5.34567
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, FABP3, FABP4, GPR35, HCAR2, HSPA1A, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MCL1, MET, MIF, MMP12, MMP9, PIK3CA, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, RORC, SMAD3, SRC, TEK, XDH 5.29806
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, HTR2A, HTR2B, HTR2C, KDR, PRKCE, SRC 5.28131
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ALOX15, BCL2, CNR1, CNR2, CYP19A1, DUSP3, EGFR, ESR1, HSPA1A, IGF1R, MCL1, MET, MIF, MMP12, MMP9, PPARA, PRKCB, PRKCD, PTGS2, SMAD3, SRC, TEK, XDH 5.24649
[BP] GO:0071073 None FABP3, HTR2A, HTR2B, HTR2C 5.21088
[BP] GO:0040017 positive regulation of locomotion APP, BCL2, EGFR, IGF1R, INSR, KDR, MET, MMP9, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TEK 5.20185
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, DUSP3, EGFR, FLT3, HTR2A, HTR2B, IGF1R, INSR, MIF, PIK3CB, PRKCD, SRC 5.18596
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4, NQO2, PTGS1, RORC 5.17956
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APP, AXL, CYP1B1, EGFR, ESR1, IGF1R, INSR, MMP2, MMP9, PIK3CA, PRKCB, PRKCD, PRKCE, PTGS2, RORC, SRC 5.16224
[BP] GO:0007193 None ADORA1, HTR1A, HTR1B, HTR1D, HTR1E, HTR5A, HTR7 5.15919
[BP] GO:0006979 response to oxidative stress AKR1B1, APP, AXL, BCL2, CYP1B1, EGFR, HSPA1A, MMP9, PRKCD, PTGS1, PTGS2, SRC 5.15533
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CNR1, CNR2, CSNK2A1, CYP1B1, DUSP3, ESR1, FABP4, GPR35, IGF1R, MET, MMP9, PIM1, PPARA, PRKCA, PRKCD, PRKCE, PTGS2, SRC 5.12909
[BP] GO:0050801 ion homeostasis APP, BCL2, CA12, CA2, CA7, EGFR, ESR1, FABP3, GPR35, HTR2A, HTR2B, HTR2C, PIK3CB, PRKCB, PRKCE, SMAD3 5.10753
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PRKCA, SRC, TEK 5.10204
[BP] GO:0002682 regulation of immune system process ADORA1, ALOX15, APP, AXL, BCL2, CA2, CNR1, CNR2, CYP19A1, DUSP3, ESR1, HCAR2, HSPA1A, MIF, MMP12, MMP2, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, SMAD3, SRC 5.04494
[BP] GO:0051240 positive regulation of multicellular organismal process APP, AXL, BCL2, CA2, CNR1, CYP1B1, EGFR, HCAR2, HSPA1A, HTR2A, HTR2B, KDR, MET, MIF, MMP12, MMP9, PIM1, PRKCA, PRKCB, PRKCE, PTGS2, SMAD3, SRC, TEK 5.01518
[BP] GO:1903530 regulation of secretion by cell ACHE, ADORA1, CNR1, CYP19A1, EGFR, HCAR2, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, MIF, MMP12, PRKCA, PRKCE, SRC 5.00188
[BP] GO:0031347 regulation of defense response ADORA1, CNR1, CNR2, CYP19A1, EGFR, ESR1, FABP4, HSPA1A, MMP12, MMP2, PPARA, PRKCD, PRKCE, PTGS2, SMAD3, SRC, TEK 4.90723
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PRKCA, PRKCE, PTGS2, SRC, TEK 4.89359
[BP] GO:0009892 negative regulation of metabolic process ADORA1, APP, AURKB, BCL2, CNR1, CNR2, CSNK2A1, DUSP3, EGFR, ESR1, FABP4, HCAR2, HSPA1A, HTR1B, HTR1E, HTR2B, IGF1R, KDR, MCL1, MET, MIF, MMP12, MMP9, PIK3CA, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, RORC, SMAD3, SRC, XDH 4.87297
[BP] GO:0043269 regulation of ion transport ADORA1, APP, BCL2, CA2, CA7, CNR1, GPR35, HTR1A, HTR1B, HTR2A, MIF, MMP9, PRKCD, PRKCE, PTGS2 4.86686
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, APP, AURKB, BCL2, CNR1, CNR2, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, FABP4, FLT3, GPR35, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, MET, MIF, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, SMAD3, SRC, TEK, XDH 4.85099
[BP] GO:0090066 None ADORA1, ALOX15, EGFR, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PRKCD, PRKCE, PTGS2 4.83637
[BP] GO:0050994 None ADORA1, CNR1, HCAR2, PPARA, PRKCD, PRKCE 4.81986
[BP] GO:0090087 None ACHE, ADORA1, APP, CA2, CNR1, EGFR, HCAR2, HTR2B, HTR2C, MIF, MMP12, PRKCA, PRKCD, PRKCE, PTGS2, SMAD3, SRC 4.72901
[BP] GO:0007610 None APP, BCL2, CNR1, EGFR, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, INSR, PPARA, PRKCE, PRKCG, PTGS2 4.70731
[BP] GO:0050727 regulation of inflammatory response ADORA1, CNR1, CNR2, CYP19A1, EGFR, ESR1, FABP4, PPARA, PRKCD, PTGS2, SMAD3, TEK 4.61003
[BP] GO:0051046 None ACHE, ADORA1, CNR1, CYP19A1, EGFR, HCAR2, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, MIF, MMP12, PRKCA, PRKCE, SRC 4.59275
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, APP, AXL, BCL2, CA2, CNR1, CYP1B1, EGFR, ESR1, GPR35, HCAR2, HSPA1A, HTR2A, HTR2B, HTR2C, INSR, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, SMAD3, SRC, TEK, XDH 4.58281
[BP] GO:0098771 inorganic ion homeostasis APP, BCL2, CA12, CA2, CA7, EGFR, ESR1, GPR35, HTR2A, HTR2B, HTR2C, PIK3CB, PRKCB, PRKCE, SMAD3 4.58212
[BP] GO:0016477 cell migration AXL, CNR2, CYP1B1, EGFR, FUT7, HTR2B, HTR6, KDR, MIF, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, PRKCD, SRC, TEK 4.57009
[BP] GO:0003008 None ADORA1, AKR1B1, APP, BCL2, CNR1, CNR2, CYP1B1, EGFR, HSD11B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, INSR, PIK3CA, PRKCG, PTGS2, SRC, TEK, TYR 4.55715
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, HSPA1A, MCL1, MIF, MMP9, PTGS2, SRC 4.53407
[BP] GO:0014065 phosphatidylinositol 3-kinase signaling HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB 4.52882
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, CNR1, EGFR, HTR1B, HTR2A, PTGS2 4.50805
[BP] GO:0032787 None ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, MIF, PPARA, PTGS1, PTGS2, TBXAS1 4.49652
[BP] GO:0032845 None ADORA1, BCL2, HTR2A, HTR2B, HTR2C, MIF, PRKCE, SRC 4.45588
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.42896
[BP] GO:0046883 regulation of hormone secretion ADORA1, CNR1, CYP19A1, EGFR, HCAR2, HTR1A, HTR2A, HTR2C, PRKCA, PRKCE 4.41369
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, APP, AXL, BCL2, CA2, CYP19A1, EGFR, HCAR2, HTR2B, INSR, MIF, MMP12, PRKCD, PRKCE, PTGS2, SMAD3, SRC 4.41247
[BP] GO:0030155 regulation of cell adhesion ALOX15, BCL2, CYP1B1, DUSP3, KDR, NUAK1, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, SMAD3, SRC, TEK 4.37812
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALOX15, ALPL, APP, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, FLT3, HSD11B1, HSD17B2, HTR5A, INSR, KDR, MCL1, MMP9, PIK3CA, PIM1, POLB, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, TYR 4.36517
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ALOX15, APP, AURKB, BCL2, CSNK2A1, EGFR, ESR1, FLT3, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, RORC, SMAD3, SRC, TEK, XDH 4.36476
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PRKCA, SMAD3, SRC, TEK 4.34398
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, CNR2, HTR1B, HTR2A, PTGS2 4.32133
[BP] GO:0046889 None FABP3, HTR2A, HTR2B, HTR2C, PRKCD, PTGS2 4.32133
[BP] GO:0072507 divalent inorganic cation homeostasis APP, BCL2, EGFR, ESR1, GPR35, HTR2A, HTR2B, HTR2C, PIK3CB, PRKCB, PRKCE, SMAD3 4.31138
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA 4.31138
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK 4.30627
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, INSR, MET, PIK3CA, PIK3CB, SRC, TEK 4.30627
[BP] GO:0051896 regulation of protein kinase B signaling AXL, EGFR, INSR, MET, PIK3CA, PIK3CB, SRC, TEK, XDH 4.25981
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, EGFR, FLT3, HSD11B2, HTR1B, PTGS2, SRC 4.24526
[BP] GO:0019725 cellular homeostasis APP, BCL2, CA2, CA7, ESR1, GPR35, HTR2A, HTR2B, HTR2C, MCL1, PIK3CA, PIK3CB, POLA1, PRKCB, PRKCE, SMAD3 4.24216
[BP] GO:1901652 response to peptide AKR1B1, APP, FABP3, HSD11B2, IGF1R, INSR, PPARA, PRKCD, PTGS2, SRC, TEK 4.22935
[BP] GO:0007188 None ADORA1, CNR1, HTR1A, HTR1B, HTR1D, HTR1E, HTR5A, HTR7 4.22935
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, EGFR, MMP9, PRKCD, SRC 4.20143
[BP] GO:0032268 regulation of cellular protein metabolic process ADORA1, ALOX15, APP, BCL2, CSNK2A1, DUSP3, EGFR, ESR1, FABP4, FLT3, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MIF, MMP9, NUAK1, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, SMAD3, SRC, TEK, XDH 4.19731
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, HTR2A, INSR, MET, SMAD3, SRC 4.1926
[BP] GO:1904951 positive regulation of establishment of protein localization ACHE, APP, BCL2, EGFR, HCAR2, HTR2B, MIF, MMP12, PRKCD, PRKCE, PTGS2, SMAD3, SRC 4.18862
[BP] GO:0046456 icosanoid biosynthetic process ALOX15, ALOX5, MIF, PTGS1, PTGS2 4.183
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, EGFR, HTR1B, KDR, PRKCD, PRKCE, PTGS2, SRC 4.183
[BP] GO:2000811 negative regulation of anoikis BCL2, MCL1, PIK3CA, SRC 4.183
[BP] GO:0071071 None FABP3, HTR2A, HTR2B, HTR2C 4.183
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, DUSP3, ESR1, HSPA1A, IGF1R, MCL1, MET, MIF, MMP9, PRKCD, PTGS2, SRC, XDH 4.17831
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, EGFR, ESR1, HTR7, PPARA, PRKCG, RORC, SRC 4.15908
[BP] GO:0048545 response to steroid hormone ALPL, BCL2, CA2, EGFR, FLT3, HSD11B2, HTR1B, PTGS2, SRC 4.15074
[BP] GO:0010513 None HTR2A, HTR2B, HTR2C 4.08952
[BP] GO:0040011 locomotion AXL, CNR2, CYP1B1, EGFR, FUT7, HTR2B, HTR6, KDR, MET, MIF, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, PRKCD, SRC, TEK 4.08188
[BP] GO:0048870 cell motility AXL, CNR2, CYP1B1, EGFR, FUT7, HTR2B, HTR6, KDR, MIF, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, PRKCD, SRC, TEK 4.07453
[BP] GO:0018105 peptidyl-serine phosphorylation AURKB, BCL2, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC 4.07212
[BP] GO:0001503 ossification ALOX15, ALPL, BCL2, EGFR, MMP2, MMP9, TEK 4.06939
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, APP, AXL, BCL2, CA1, CSNK2A1, EGFR, FLT3, GPR35, IGF1R, INSR, KDR, MCL1, MET, MIF, MMP2, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, SMAD3, SRC, TEK 4.04815
[BP] GO:0050728 negative regulation of inflammatory response ADORA1, CNR2, CYP19A1, PPARA, PRKCD, SMAD3, TEK 4.04703
[BP] GO:0055080 cation homeostasis APP, BCL2, CA2, CA7, EGFR, ESR1, GPR35, HTR2A, HTR2B, HTR2C, PIK3CB, PRKCB, PRKCE, SMAD3 4.008
[BP] GO:0002791 None ACHE, ADORA1, CNR1, EGFR, HCAR2, HTR2B, HTR2C, MIF, MMP12, PRKCA, PRKCE, SRC 4.00346
[BP] GO:2000377 regulation of reactive oxygen species metabolic process BCL2, CYP1B1, EGFR, INSR, PRKCD, PTGS2, SMAD3, XDH 4.00346
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ALOX15, APP, AURKB, BCL2, EGFR, ESR1, FABP3, FLT3, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, RORC, SMAD3, SRC, TEK, XDH 3.9843
[BP] GO:0099536 None CNR1, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, PRKCG 3.9843
[BP] GO:0099537 None CNR1, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, PRKCG 3.9843
[BP] GO:0050730 None ADORA1, APP, EGFR, FLT3, HTR2A, MIF, PRKCD, PRKCE, SRC 3.9843
[BP] GO:0007568 aging AURKB, BCL2, CNR1, CYP1A1, HTR2A, MIF, POLB, PRKCD, PTGS2 3.9843
[BP] GO:0031348 negative regulation of defense response ADORA1, CNR2, CYP19A1, MMP12, PPARA, PRKCD, SMAD3, TEK 3.97458
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ALOX15, APP, AURKB, BCL2, CSNK2A1, EGFR, ESR1, FLT3, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, RORC, SMAD3, SRC, TEK, XDH 3.95284
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, HTR1B, MMP2, MMP9, PTGS2 3.94188
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, BCL2, CYP1B1, EGFR, MMP9, PRKCD, SRC 3.92253
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, APP, CA2, CA7, EGFR, PRKCE, PTGS2 3.91886
[BP] GO:0006874 cellular calcium ion homeostasis APP, BCL2, ESR1, GPR35, HTR2A, HTR2B, HTR2C, PIK3CB, PRKCB, PRKCE, SMAD3 3.91367
[BP] GO:0051130 positive regulation of cellular component organization ALOX15, APP, AURKB, AXL, BCL2, CNR1, ESR1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, PRKCD, PRKCE, SMAD3, SRC, TEK 3.91367
[BP] GO:0043549 regulation of kinase activity ADORA1, APP, DUSP3, EGFR, FABP4, FLT3, HTR2A, HTR2B, IGF1R, INSR, MIF, PIK3CA, PIK3CB, PRKCD, SRC, TEK 3.86549
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, BCL2, CYP1A1, EGFR, PPARA, SMAD3 3.83804
[BP] GO:0055082 cellular chemical homeostasis APP, BCL2, CA2, CA7, ESR1, GPR35, HTR2A, HTR2B, HTR2C, PIK3CA, PIK3CB, PRKCB, PRKCE, SMAD3 3.83611
[BP] GO:0032229 None ADORA1, CNR2, HTR1B 3.82983
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.81159
[BP] GO:0055074 calcium ion homeostasis APP, BCL2, ESR1, GPR35, HTR2A, HTR2B, HTR2C, PIK3CB, PRKCB, PRKCE, SMAD3 3.79344
[BP] GO:0030003 cellular cation homeostasis APP, BCL2, CA2, CA7, ESR1, GPR35, HTR2A, HTR2B, HTR2C, PIK3CB, PRKCB, PRKCE, SMAD3 3.78711
[BP] GO:0018209 peptidyl-serine modification AURKB, BCL2, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC 3.76074
[BP] GO:0010038 response to metal ion ALOX15, APP, BCL2, CA2, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 3.76054
[BP] GO:0051222 positive regulation of protein transport ACHE, APP, EGFR, HCAR2, HTR2B, MIF, MMP12, PRKCD, PRKCE, PTGS2, SMAD3, SRC 3.76054
[BP] GO:0072503 cellular divalent inorganic cation homeostasis APP, BCL2, ESR1, GPR35, HTR2A, HTR2B, HTR2C, PIK3CB, PRKCB, PRKCE, SMAD3 3.75095
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 3.72023
[BP] GO:0010810 regulation of cell-substrate adhesion ALOX15, BCL2, KDR, PIK3CB, PRKCE, SMAD3, SRC, TEK 3.69854
[BP] GO:0006873 cellular ion homeostasis APP, BCL2, CA2, CA7, ESR1, GPR35, HTR2A, HTR2B, HTR2C, PIK3CB, PRKCB, PRKCE, SMAD3 3.68266
[BP] GO:0002793 None ACHE, ADORA1, EGFR, HCAR2, HTR2B, MIF, MMP12, PRKCE, SRC 3.66882
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ALOX15, APP, AURKB, BCL2, CSNK2A1, EGFR, ESR1, FABP3, FLT3, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, RORC, SMAD3, SRC, TEK, XDH 3.65607
[BP] GO:0031329 regulation of cellular catabolic process BCL2, CNR1, HSPA1A, HTR2A, HTR2B, INSR, KDR, MCL1, MET, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCG 3.64019
[BP] GO:0051051 negative regulation of transport ADORA1, APP, BCL2, CNR1, GPR35, HSPA1A, HTR1B, HTR2A, MMP9, PRKCB, PRKCE, PTGS2 3.64019
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APP, EGFR, ESR1, FLT3, HTR1B, IGF1R, INSR, MMP2, PRKCD, PRKCE, PTGS2, SMAD3, SRC 3.64019
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DUSP3, EGFR, ESR1, FABP3, FABP4, FLT3, FUT7, GPR35, HCAR2, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MCL1, MET, MIF, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, RORC, SMAD3, SRC, TBXAS1, TEK, TYR, XDH 3.64019
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6 3.62338
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6 3.62338
[BP] GO:0010511 None HTR2A, HTR2B, HTR2C 3.62338
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, PRKCD, SRC 3.61725
[BP] GO:0045859 regulation of protein kinase activity ADORA1, APP, DUSP3, EGFR, FABP4, FLT3, HTR2A, HTR2B, IGF1R, INSR, MIF, PIK3CA, PIK3CB, PRKCD, SRC 3.61241
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALOX15, APP, BCL2, CYP19A1, CYP1A1, CYP1B1, CYP3A4, HTR1A, TYR 3.61241
[BP] GO:0044093 positive regulation of molecular function ADORA1, APP, AURKB, BCL2, EGFR, ESR1, FLT3, HSPA1A, HTR2A, HTR2B, INSR, MET, MIF, MMP9, PIK3CA, PIK3CB, PRKCB, PRKCD, PRKCE, SMAD3, SRC, TEK, XDH 3.60888
[BP] GO:0002684 positive regulation of immune system process APP, AXL, BCL2, CA2, CNR1, HCAR2, HSPA1A, MIF, MMP12, MMP2, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, SRC 3.59848
[BP] GO:2000209 regulation of anoikis BCL2, MCL1, PIK3CA, SRC 3.59848
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADORA1, DUSP3, EGFR, FLT3, HTR2A, HTR2B, IGF1R, INSR, MIF, PIK3CB, PRKCD, SRC 3.59372
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APP, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DUSP3, EGFR, ESR1, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR1B, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, RORC, SMAD3, SRC, TBXAS1, TEK, TYR, XDH 3.58641
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ALOX15, APP, AURKB, BCL2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, FABP3, FABP4, FLT3, HCAR2, HSPA1A, HTR1A, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MCL1, MET, MIF, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, RORC, SMAD3, SRC, TEK, XDH 3.57911
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, EGFR, FLT3, HTR2A, HTR2B, INSR, MIF, PIK3CB, SRC 3.57404
[BP] GO:2000379 positive regulation of reactive oxygen species metabolic process EGFR, INSR, PRKCD, PTGS2, SMAD3, XDH 3.57267
[BP] GO:0051338 regulation of transferase activity ADORA1, APP, AURKB, DUSP3, EGFR, FABP4, FLT3, HTR2A, HTR2B, IGF1R, INSR, MIF, PIK3CA, PIK3CB, PRKCD, SRC, TEK 3.56675
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.5304
[BP] GO:0051246 regulation of protein metabolic process ADORA1, ALOX15, APP, BCL2, CSNK2A1, DUSP3, EGFR, ESR1, FABP4, FLT3, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MIF, MMP9, NUAK1, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, SMAD3, SRC, TEK, XDH 3.51167
[BP] GO:0006928 movement of cell or subcellular component APP, AXL, CNR2, CYP1B1, EGFR, FUT7, HTR2B, HTR6, KDR, MIF, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PTGS2, SRC, TEK 3.51167
[BP] GO:0043393 regulation of protein binding APP, AURKB, BCL2, MET, MMP9, PPARA, PRKCD, SRC 3.46342
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APP, CYP1A1, CYP1B1, EGFR, ESR1, FLT3, PTGS2, RORC, SRC 3.44197
[BP] GO:0006954 inflammatory response ADORA1, ADORA3, ALOX15, AXL, CNR2, MIF, PIK3CA, PIK3CB, POLB, PTGS1, PTGS2 3.43077
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APP, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DUSP3, EGFR, ESR1, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, RORC, SMAD3, SRC, TBXAS1, TEK, TYR, XDH 3.42375
[BP] GO:0070201 None ACHE, APP, BCL2, CNR1, EGFR, HCAR2, HTR2B, MIF, MMP12, PRKCA, PRKCD, PRKCE, PTGS2, SMAD3, SRC 3.41193
[BP] GO:0071248 cellular response to metal ion ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 3.41193
[BP] GO:0032103 positive regulation of response to external stimulus CNR1, EGFR, FABP4, KDR, MET, MIF, PRKCA, PTGS2, SMAD3 3.39811
[BP] GO:0008217 None ADORA1, CNR1, HSD11B2, PPARA, PTGS1, PTGS2, SMAD3 3.39527
[BP] GO:0033138 positive regulation of peptidyl-serine phosphorylation APP, BCL2, EGFR, MIF, PIK3CA, PTGS2 3.35191
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, APP, AURKB, BCL2, EGFR, ESR1, FLT3, HSPA1A, HTR2A, HTR2B, INSR, MIF, PIK3CA, PIK3CB, PRKCD, PRKCE, SMAD3, SRC, TEK, XDH 3.35012
[BP] GO:0031324 negative regulation of cellular metabolic process APP, AURKB, BCL2, CNR1, CSNK2A1, DUSP3, ESR1, FABP4, HSPA1A, HTR1B, HTR1E, HTR2B, IGF1R, MCL1, MET, MIF, MMP12, MMP9, PIK3CA, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, RORC, SMAD3, SRC, XDH 3.32718
[BP] GO:0010632 regulation of epithelial cell migration KDR, MET, MMP9, PRKCA, PRKCE, PTGS2, SRC, TEK 3.32718
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, HTR2A, MET, SRC 3.31193
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, HTR2A, MET, SRC 3.31193
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, HTR2A, MET, SRC 3.31193
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, HTR2A, MET, SRC 3.31193
[BP] GO:0033032 regulation of myeloid cell apoptotic process BCL2, HCAR2, MIF, PIK3CB 3.28545
[BP] GO:0016572 histone phosphorylation AURKB, PRKCA, PRKCB, PRKCD 3.28545
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA 3.28464
[BP] GO:0055065 metal ion homeostasis APP, BCL2, EGFR, ESR1, GPR35, HTR2A, HTR2B, HTR2C, PIK3CB, PRKCB, PRKCE, SMAD3 3.28464
[BP] GO:0001952 regulation of cell-matrix adhesion BCL2, KDR, PIK3CB, SMAD3, SRC, TEK 3.27278
[BP] GO:0033674 positive regulation of kinase activity ADORA1, EGFR, FLT3, HTR2A, HTR2B, INSR, MIF, PIK3CA, PIK3CB, PRKCD, SRC, TEK 3.26552
[BP] GO:0007268 None HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, PRKCG 3.26552
[BP] GO:0098916 None HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, PRKCG 3.26552
[BP] GO:0045787 positive regulation of cell cycle APP, AURKB, CYP1A1, DUSP3, EGFR, INSR, MIF, PRKCA, PRKCE, SRC 3.26552
[BP] GO:2001242 regulation of intrinsic apoptotic signaling pathway BCL2, HSPA1A, MCL1, MIF, MMP9, PTGS2, SRC 3.257
[BP] GO:0048015 phosphatidylinositol-mediated signaling HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB 3.23964
[BP] GO:0080135 regulation of cellular response to stress APP, DUSP3, EGFR, HSPA1A, IGF1R, MCL1, MET, MIF, NUAK1, PRKCD, PRKCG, PTGS2, XDH 3.23964
[BP] GO:0006636 unsaturated fatty acid biosynthetic process ALOX15, MIF, PTGS1, PTGS2 3.23964
[BP] GO:0019752 carboxylic acid metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, MIF, PIM1, PPARA, PTGS1, PTGS2, TBXAS1, TYR 3.23521
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, CNR1, EGFR, HCAR2, PIK3CB, PTGS2 3.19995
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR 3.1945
[BP] GO:0007154 None ADORA1, AXL, BCL2, CNR1, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, PRKCG, PTGS2, TEK 3.17922
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, BCL2, CYP1B1, PRKCD, SRC 3.17367
[BP] GO:0051047 None ACHE, ADORA1, CYP19A1, EGFR, HCAR2, HTR2B, MIF, MMP12, PRKCE, SRC 3.17081
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.16974
[BP] GO:0048017 inositol lipid-mediated signaling HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB 3.14925
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, ALOX15, APP, AURKB, BCL2, CA9, CNR1, CSNK2A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, FABP3, FABP4, FLT3, HCAR2, HSPA1A, HTR1A, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, RORC, SMAD3, SRC, TEK, XDH 3.12537
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1A1, CYP1A2, CYP3A4, DUSP3, EGFR, ESR1, FLT3, FUT7, HSPA1A, HTR1A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIM1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, SMAD3, SRC, TEK, TYR, XDH 3.12221
[BP] GO:0050714 None ACHE, EGFR, HCAR2, HTR2B, MIF, MMP12, PRKCE, SRC 3.08755
[BP] GO:0051223 None ACHE, APP, CNR1, EGFR, HCAR2, HTR2B, MIF, MMP12, PRKCA, PRKCD, PRKCE, PTGS2, SMAD3, SRC 3.05531
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APP, EGFR, HTR1B, IGF1R, INSR, MMP2, PRKCD, PTGS2, SRC 3.05334
[BP] GO:0006875 cellular metal ion homeostasis APP, BCL2, ESR1, GPR35, HTR2A, HTR2B, HTR2C, PIK3CB, PRKCB, PRKCE, SMAD3 3.04548
[BP] GO:0019371 None PTGS1, PTGS2, TBXAS1 3.04337
[BP] GO:0071241 cellular response to inorganic substance ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 3.04289
[BP] GO:0044089 positive regulation of cellular component biogenesis ALOX15, ESR1, HSPA1A, KDR, MET, MMP1, PRKCA, PRKCE, SMAD3, SRC, TEK 3.04178
[BP] GO:0045913 None HTR2A, INSR, PPARA, PRKCE, SRC 3.03295
[BP] GO:0010863 positive regulation of phospholipase C activity EGFR, ESR1, HTR2A, HTR2B 3.03295
[BP] GO:0006952 defense response ADORA1, ADORA3, ALOX15, APP, AXL, BCL2, CNR2, HTR1A, HTR2C, MIF, PIK3CA, PIK3CB, POLB, PRKCD, PTGS1, PTGS2, SRC 3.03286
[BP] GO:0051347 positive regulation of transferase activity ADORA1, AURKB, EGFR, FLT3, HTR2A, HTR2B, INSR, MIF, PIK3CA, PIK3CB, PRKCD, SRC, TEK 3.01775
[BP] GO:0048732 gland development BCL2, CSNK2A1, CYP19A1, EGFR, INSR, PIK3CA, SMAD3, TYR 3.00927
[BP] GO:0050776 regulation of immune response ALOX15, BCL2, CNR1, DUSP3, ESR1, HSPA1A, MIF, MMP12, MMP2, PIK3CA, PIK3CB, PRKCB, PRKCD, PRKCE, SMAD3, SRC 2.96998
[BP] GO:0001101 response to acid chemical AKR1B1, EGFR, FABP3, HSD17B2, KDR, MMP2, PRKCE, PTGS2, SRC 2.96622
[BP] GO:0032880 regulation of protein localization ACHE, APP, BCL2, CNR1, CSNK2A1, EGFR, HCAR2, HTR2B, MIF, MMP12, PRKCA, PRKCD, PRKCE, PTGS2, SMAD3, SRC 2.95263
[BP] GO:0010507 negative regulation of autophagy BCL2, HTR2B, MCL1, MET, PIK3CA 2.95084
[BP] GO:0097237 cellular response to toxic substance AKR1B1, AXL, CYP1B1, KDR, PRKCD, PRKCE 2.93979
[BP] GO:0042738 exogenous drug catabolic process CYP1A2, CYP2A6, CYP3A4 2.9379
[BP] GO:0045759 None CNR1, CNR2, GPR35 2.9379
[BP] GO:0007208 None HTR2A, HTR2C 2.93541
[BP] GO:0035408 None PRKCA, PRKCB 2.93541
[BP] GO:0048010 vascular endothelial growth factor receptor signaling pathway AXL, KDR, PIK3CA, PIK3CB, SRC 2.93541
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, ALOX15, APP, AURKB, BCL2, CA9, CNR1, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, FABP3, FABP4, FLT3, HSPA1A, HTR1A, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MCL1, MET, MIF, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, RORC, SMAD3, SRC, TEK, XDH 2.93112
[BP] GO:1900274 regulation of phospholipase C activity EGFR, ESR1, HTR2A, HTR2B 2.90476
[BP] GO:0031349 positive regulation of defense response CNR1, EGFR, FABP4, HSPA1A, MMP12, MMP2, PRKCD, PRKCE, PTGS2, SRC 2.87806
[BP] GO:0043065 positive regulation of apoptotic process BCL2, CNR1, CYP1B1, HCAR2, MCL1, MMP9, PIK3CB, PRKCD, PTGS2, SMAD3, SRC, XDH 2.87806
[BP] GO:0065007 biological regulation ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA7, CA9, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DUSP3, EGFR, ESR1, FABP3, FABP4, FLT3, GPR35, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MCL1, MET, MIF, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, RORC, SMAD3, SRC, TEK, XDH 2.87641
[BP] GO:0001525 angiogenesis CYP1B1, KDR, MMP2, PIK3CA, PIK3CB, PRKCA, PTGS2, TEK 2.8603
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR 2.85986
[BP] GO:0045860 positive regulation of protein kinase activity ADORA1, EGFR, FLT3, HTR2A, HTR2B, INSR, MIF, PIK3CA, PIK3CB, PRKCD, SRC 2.85161
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, FABP3, FABP4, FUT7, HSPA1A, MMP1, MMP12, MMP2, MMP9, PIK3CB, SRC, XDH 2.84902
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.84902
[BP] GO:0032230 positive regulation of synaptic transmission, GABAergic CA2, CA7, PRKCE 2.84902
[BP] GO:0001516 None MIF, PTGS1, PTGS2 2.84902
[BP] GO:0046457 None MIF, PTGS1, PTGS2 2.84902
[BP] GO:0043068 positive regulation of programmed cell death BCL2, CNR1, CYP1B1, HCAR2, MCL1, MMP9, PIK3CB, PRKCD, PTGS2, SMAD3, SRC, XDH 2.84682
[BP] GO:0050708 None ACHE, CNR1, EGFR, HCAR2, HTR2B, MIF, MMP12, PRKCA, PRKCE, SRC 2.83711
[BP] GO:0010638 positive regulation of organelle organization ALOX15, AURKB, BCL2, HSPA1A, INSR, KDR, MET, MMP9, PRKCE, SMAD3, SRC, TEK 2.83509
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, EGFR, HTR1B, MMP2, MMP9, PTGS2 2.81212
[BP] GO:0009968 negative regulation of signal transduction BCL2, DUSP3, EGFR, ESR1, HSPA1A, IGF1R, MCL1, MET, MIF, MMP12, MMP9, PRKCB, PRKCD, PTGS2, SMAD3, SRC, XDH 2.81052
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APP, EGFR, HTR1B, IGF1R, INSR, MMP2, PRKCD, PTGS2, SRC 2.80662
[BP] GO:0043436 oxoacid metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, MIF, PIM1, PPARA, PTGS1, PTGS2, TBXAS1, TYR 2.79556
[BP] GO:0051098 regulation of binding APP, AURKB, BCL2, MET, MMP9, PPARA, PRKCD, SMAD3, SRC 2.79045
[BP] GO:0018107 peptidyl-threonine phosphorylation BCL2, CSNK2A1, PRKCA, PRKCB, PRKCD 2.78939
[BP] GO:0038128 None EGFR, PIK3CA, PRKCA, SRC 2.78636
[BP] GO:1900182 positive regulation of protein localization to nucleus APP, EGFR, PRKCD, PTGS2, SMAD3, SRC 2.78132
[BP] GO:0009991 response to extracellular stimulus ALPL, AXL, BCL2, CNR1, CYP1A1, EGFR, HSD11B2, PTGS2, SRC, TYR 2.77851
[BP] GO:0007267 None ADORA1, CNR1, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, PRKCG, TEK 2.77035
[BP] GO:0033135 regulation of peptidyl-serine phosphorylation APP, BCL2, EGFR, MIF, PIK3CA, PTGS2 2.76561
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.76215
[BP] GO:0051967 None ADORA1, HTR1B, HTR2A 2.76215
[BP] GO:1901570 None ALOX15, ALOX5, MIF, PTGS1, PTGS2 2.74424
[BP] GO:0071902 positive regulation of protein serine/threonine kinase activity ADORA1, EGFR, FLT3, HTR2A, HTR2B, INSR, MIF, PIK3CB, SRC 2.72356
[BP] GO:0050900 leukocyte migration CNR2, FUT7, MIF, MMP1, MMP9, PIK3CA, PIK3CB, SRC, TEK 2.72356
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4 2.72353
[BP] GO:0006082 organic acid metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, MIF, PIM1, PPARA, PTGS1, PTGS2, TBXAS1, TYR 2.72116
[BP] GO:1904407 positive regulation of nitric oxide metabolic process EGFR, INSR, PTGS2, SMAD3 2.71216
[BP] GO:0045429 positive regulation of nitric oxide biosynthetic process EGFR, INSR, PTGS2, SMAD3 2.71216
[BP] GO:0050890 None ADORA1, APP, CNR1, EGFR, HTR2A, INSR, PRKCG, PTGS2 2.70479
[BP] GO:2000106 regulation of leukocyte apoptotic process AURKB, AXL, HCAR2, MIF, PIK3CB 2.70331
[BP] GO:0044070 regulation of anion transport ADORA1, CA2, CA7, MIF, PRKCD 2.70331
[BP] GO:0033273 response to vitamin ALPL, CYP1A1, EGFR, PTGS2, TYR 2.70331
[BP] GO:0097190 apoptotic signaling pathway ADORA1, BCL2, CYP1B1, MCL1, POLB, PRKCA, PRKCD, SMAD3 2.68719
[BP] GO:1903532 None ACHE, CYP19A1, EGFR, HCAR2, HTR2B, MIF, MMP12, PRKCE, SRC 2.68671
[BP] GO:0032496 response to lipopolysaccharide ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, PTGS2, SRC 2.65768
[BP] GO:0043434 None FABP3, HSD11B2, INSR, PPARA, PRKCD, PTGS2, SRC, TEK 2.6476
[BP] GO:0051384 response to glucocorticoid ALPL, BCL2, EGFR, FLT3, HSD11B2, PTGS2 2.64184
[BP] GO:0032102 negative regulation of response to external stimulus ADORA1, CNR2, CYP19A1, MIF, PPARA, PRKCD, SMAD3, TEK 2.63853
[BP] GO:0018210 peptidyl-threonine modification BCL2, CSNK2A1, PRKCA, PRKCB, PRKCD 2.63779
[BP] GO:0010595 positive regulation of endothelial cell migration KDR, MET, PRKCA, PTGS2, TEK 2.63779
[BP] GO:0002009 morphogenesis of an epithelium BCL2, CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC 2.6106
[BP] GO:0050999 None CNR1, CNR2, EGFR, HTR2B 2.60793
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.60527
[BP] GO:0019372 lipoxygenase pathway ALOX15, ALOX5, PTGS2 2.60527
[BP] GO:0050865 regulation of cell activation APP, AXL, BCL2, CNR1, CNR2, DUSP3, MIF, PIK3CA, PRKCA, PRKCD, SRC 2.58482
[BP] GO:0010942 positive regulation of cell death BCL2, CNR1, CYP1B1, HCAR2, MCL1, MMP9, PIK3CB, PRKCD, PTGS2, SMAD3, SRC, XDH 2.57563
[BP] GO:0051283 None HTR2A, HTR2B, HTR2C, PRKCE 2.57563
[BP] GO:0051209 None HTR2A, HTR2B, HTR2C, PRKCE 2.57563
[BP] GO:2001234 negative regulation of apoptotic signaling pathway BCL2, HSPA1A, MCL1, MIF, MMP9, PTGS2, SRC 2.56494
[BP] GO:0031330 negative regulation of cellular catabolic process BCL2, CNR1, HTR2B, MCL1, MET, PIK3CA, PRKCG 2.55292
[BP] GO:0051054 positive regulation of DNA metabolic process AURKB, EGFR, IGF1R, INSR, PRKCD, PRKCG, SRC 2.54189
[BP] GO:0009410 None CNR1, CNR2, EGFR, HTR1B, PRKCE, PRKCG 2.54072
[BP] GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress BCL2, CYP1B1, PRKCD 2.53385
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.53385
[BP] GO:0051094 positive regulation of developmental process APP, AXL, BCL2, CA2, CNR1, CYP1B1, HTR2A, HTR2C, INSR, KDR, PIM1, PRKCA, PRKCB, PTGS2, SMAD3, SRC, TEK 2.52118
[BP] GO:0033554 cellular response to stress AKR1B1, ALOX15, AXL, BCL2, CA2, CA9, CYP1B1, EGFR, HSPA1A, MCL1, MIF, MMP9, NUAK1, POLA1, POLB, PRKCD, PRKCE, PTGS2, SRC 2.52118
[BP] GO:2001233 regulation of apoptotic signaling pathway BCL2, HSPA1A, MCL1, MIF, MMP9, PRKCD, PTGS2, SMAD3, SRC 2.49335
[BP] GO:0009266 None ADORA1, HSPA1A, HTR1B, HTR2A, HTR2B, PTGS2 2.48807
[BP] GO:0002237 response to molecule of bacterial origin ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, PTGS2, SRC 2.48807
[BP] GO:0006939 None HTR1D, HTR2A, HTR2B, HTR7 2.48262
[BP] GO:0010518 positive regulation of phospholipase activity EGFR, ESR1, HTR2A, HTR2B 2.44897
[BP] GO:0045766 positive regulation of angiogenesis CYP1B1, KDR, PRKCA, PRKCB, PTGS2, TEK 2.42857
[BP] GO:0031334 positive regulation of protein complex assembly ALOX15, ESR1, HSPA1A, MET, MMP1, PRKCE, SRC 2.41152
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.39985
[BP] GO:0051726 regulation of cell cycle APP, AURKB, BCL2, CSNK2A1, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, MIF, PIM1, PRKCA, PRKCE, PTGS2, SMAD3, SRC 2.3959
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA1, ADORA3, ALOX15, APP, AURKB, BCL2, CA9, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, FABP3, FABP4, FLT3, HSPA1A, HTR1A, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, RORC, SMAD3, SRC, TEK, XDH 2.3869
[BP] GO:0042307 positive regulation of protein import into nucleus APP, EGFR, PRKCD, PTGS2, SMAD3 2.37966
[BP] GO:0023052 None ADORA1, CNR1, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, PRKCG, TEK 2.37966
[BP] GO:0006811 None CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, HTR2A, HTR2B, HTR2C, PPARA, PRKCB, PRKCE 2.36945
[BP] GO:1903428 positive regulation of reactive oxygen species biosynthetic process EGFR, INSR, PTGS2, SMAD3 2.35772
[BP] GO:0010676 None INSR, PPARA, PRKCE, SRC 2.35772
[BP] GO:0050793 regulation of developmental process APP, AXL, BCL2, CA2, CNR1, CYP1B1, EGFR, ESR1, HTR2A, HTR2C, INSR, KDR, MIF, NUAK1, PIK3CA, PIM1, PPARA, PRKCA, PRKCB, PTGS2, RORC, SMAD3, SRC, TEK, XDH 2.35668
[BP] GO:1904591 positive regulation of protein import APP, EGFR, PRKCD, PTGS2, SMAD3 2.34354
[BP] GO:0046486 glycerolipid metabolic process ACHE, ALOX15, CSNK2A1, EGFR, FABP3, FABP4, MET, PIK3CA, PIK3CB 2.31908
[BP] GO:0031667 response to nutrient levels ALPL, BCL2, CNR1, CYP1A1, EGFR, HSD11B2, PTGS2, SRC, TYR 2.31183
[BP] GO:0007611 None APP, CNR1, EGFR, HTR2A, INSR, PRKCG, PTGS2 2.30886
[BP] GO:0072593 reactive oxygen species metabolic process BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR 2.30886
[BP] GO:0002683 negative regulation of immune system process ADORA1, ALOX15, AXL, CNR1, CNR2, CYP19A1, DUSP3, MIF, MMP12 2.30716
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.30447
[BP] GO:0033555 multicellular organismal response to stress BCL2, HTR1A, HTR2C, PRKCG 2.30447
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.30447
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.28429
[BP] GO:0046649 lymphocyte activation AXL, BCL2, FLT3, FUT7, PRKCB, PRKCD, RORC, SMAD3 2.27953
[BP] GO:0032768 None CNR1, CNR2, EGFR, HTR2B 2.27652
[BP] GO:0033031 positive regulation of neutrophil apoptotic process HCAR2, PIK3CB 2.27321
[BP] GO:0038171 None CNR1, CNR2 2.27321
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.27321
[BP] GO:0014827 None HTR1D, HTR2B 2.27321
[BP] GO:0050778 positive regulation of immune response BCL2, CNR1, HSPA1A, MIF, MMP12, MMP2, PIK3CA, PIK3CB, PRKCB, PRKCD, PRKCE, SRC 2.26755
[BP] GO:0048534 hematopoietic or lymphoid organ development BCL2, FLT3, KDR, POLB, TEK, TYR 2.26755
[BP] GO:0046890 None FABP3, HTR2A, HTR2B, HTR2C, PRKCD, PTGS2 2.26755
[BP] GO:0010811 positive regulation of cell-substrate adhesion ALOX15, KDR, PRKCE, SMAD3, TEK 2.24597
[BP] GO:0045321 leukocyte activation ALOX5, AXL, BCL2, FLT3, FUT7, HSPA1A, MIF, MMP9, PRKCB, PRKCD, PRKCE, RORC, SMAD3 2.24099
[BP] GO:0022612 gland morphogenesis BCL2, EGFR, POLB 2.23788
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation HTR1B, MMP2, MMP9 2.23788
[BP] GO:0050995 None ADORA1, CNR1, HCAR2 2.23788
[BP] GO:0050996 None PPARA, PRKCD, PRKCE 2.23788
[BP] GO:0097553 None HTR2A, HTR2B, HTR2C, PRKCE 2.23241
[BP] GO:0072347 None CNR1, HTR1B, PRKCE, PRKCG 2.23241
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.23241
[BP] GO:0045428 regulation of nitric oxide biosynthetic process EGFR, INSR, PTGS2, SMAD3 2.23241
[BP] GO:0044057 None ADORA1, ADORA3, EGFR, GPR35, HCAR2, HTR2A, HTR2C, PRKCA, PTGS2, SMAD3 2.21662
[BP] GO:0050678 None EGFR, HTR2B, KDR, MMP12, PRKCA, SMAD3, TEK, XDH 2.20846
[BP] GO:1902905 positive regulation of supramolecular fiber organization ALOX15, APP, HSPA1A, MET, PRKCE, SMAD3 2.19527
[BP] GO:0022414 reproductive process AKR1B1, ALPL, APP, AXL, BCL2, CNR1, CYP19A1, CYP1A1, EGFR, ESR1, HSD11B2, HSD17B2, INSR, MMP2, MMP9, PTGS2, SRC 2.19404
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.18673
[BP] GO:0050794 regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CA1, CA2, CA7, CA9, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, FABP3, FABP4, FLT3, GPR35, HCAR2, HSPA1A, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MCL1, MET, MIF, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, RORC, SMAD3, SRC, TEK, XDH 2.18515
[BP] GO:0006109 regulation of carbohydrate metabolic process HTR2A, INSR, PPARA, PRKCE, RORC, SRC 2.18485
[BP] GO:0010517 regulation of phospholipase activity EGFR, ESR1, HTR2A, HTR2B 2.1812
[BP] GO:0050679 None EGFR, HTR2B, KDR, MMP12, PRKCA, TEK 2.1737
[BP] GO:1904018 positive regulation of vasculature development CYP1B1, KDR, PRKCA, PRKCB, PTGS2, TEK 2.1737
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, EGFR, HSPA1A 2.16413
[BP] GO:0051894 None KDR, SMAD3, TEK 2.13913
[BP] GO:0007202 None EGFR, HTR2A, HTR2B 2.13913
[BP] GO:0032098 None HTR2C, HTR4, PPARA 2.13913
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.13913
[BP] GO:1901654 None AKR1B1, CA9, CSNK2A1, EGFR, PRKCE, SRC 2.13913
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, AXL, CYP1B1, PRKCD 2.13276
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, EGFR, HTR1A, INSR, PTGS2, SMAD3 2.12991
[BP] GO:0060193 positive regulation of lipase activity EGFR, ESR1, HTR2A, HTR2B 2.1069
[BP] GO:0051704 multi-organism process APP, AXL, BCL2, CYP1A1, EGFR, HSD11B2, HSPA1A, HTR2A, INSR, KDR, MET, MMP1, MMP12, POLA1, PRKCD, SMAD3, SRC 2.09801
[BP] GO:0044283 None AKR1B1, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP3A4, MIF, PTGS1, PTGS2 2.09375
[BP] GO:0071502 None HTR1B, HTR2B 2.08538
[BP] GO:0051248 None APP, CSNK2A1, DUSP3, EGFR, FABP4, HSPA1A, IGF1R, MIF, MMP9, PRKCD, PRKCE, PRKCG, PTGS2, SMAD3, SRC, XDH 2.07299
[BP] GO:0060402 None HTR2A, HTR2B, HTR2C, PRKCE 2.06043
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, HTR2A, MET, PIK3CA 2.05959
[BP] GO:0009896 positive regulation of catabolic process CSNK2A1, HSPA1A, HTR2A, INSR, KDR, PIK3CB, PPARA, PRKCD, PRKCE 2.057
[BP] GO:0009605 response to external stimulus ADORA1, ALPL, AXL, BCL2, CNR1, CNR2, CYP1A1, CYP1A2, EGFR, HSD11B2, HTR2A, MMP12, PRKCD, PTGS2, SMAD3, SRC, TYR 2.05116
[BP] GO:0006706 steroid catabolic process CYP19A1, CYP1A2, CYP3A4 2.05004
[BP] GO:1903393 None KDR, SMAD3, TEK 2.05004
[BP] GO:0006693 None MIF, PTGS1, PTGS2 2.05004
[BP] GO:0006692 None MIF, PTGS1, PTGS2 2.05004
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.04199
[BP] GO:0007346 regulation of mitotic cell cycle APP, AURKB, BCL2, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, PIM1, PRKCA, SMAD3 2.03466
[BP] GO:0045598 None HTR2A, HTR2C, PTGS2, RORC, SMAD3 2.03398
[BP] GO:0048729 tissue morphogenesis BCL2, CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC 2.02417
[BP] GO:0010675 None INSR, PPARA, PRKCE, RORC, SRC 2.01948
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ALOX15, ALOX5, ALPL, APP, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, EGFR, ESR1, FLT3, FUT7, GPR35, HCAR2, HSD11B1, HSD11B2, HSD17B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MCL1, MET, MMP2, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, SMAD3, SRC, TBXAS1, TEK, TYR 6.77885
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ALOX15, ALPL, APP, AXL, CA12, CA14, CA2, CA4, CA9, CNR1, CNR2, CSNK2A1, EGFR, ESR1, FLT3, GPR35, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, MMP2, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SMAD3, SRC, TEK 6.69671
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, APP, AXL, CA4, CNR1, CNR2, FLT3, GPR35, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, TEK 5.93613
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, ALOX15, ALPL, APP, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CNR1, CNR2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DUSP3, EGFR, ESR1, FLT3, FUT7, GPR35, HCAR2, HSD11B1, HSD11B2, HSD17B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MCL1, MET, MPEG1, PIK3CA, PIK3CB, PRKCG, PTGS1, PTGS2, SRC, TBXAS1, TEK, TYR 5.89964
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, APP, AXL, CNR1, CNR2, FLT3, GPR35, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, TEK 5.66018
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, ALOX15, APP, AXL, CA2, CA4, CA9, CNR1, CNR2, DUSP3, EGFR, FLT3, GPR35, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, PRKCG, PTGS2, SRC, TEK 5.25032
[CC] GO:0045121 membrane raft APP, CNR1, EGFR, HTR2A, INSR, KDR, PTGS2, SRC, TEK 3.257
[CC] GO:0098857 membrane microdomain APP, CNR1, EGFR, HTR2A, INSR, KDR, PTGS2, SRC, TEK 3.23964
[CC] GO:0005789 endoplasmic reticulum membrane BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, EGFR, HSD11B1, HSD11B2, HSD17B2, PTGS1, PTGS2, TBXAS1 2.93541
[CC] GO:0098589 membrane region APP, CNR1, EGFR, HTR2A, INSR, KDR, PTGS2, SRC, TEK 2.70331
[CC] GO:0048471 perinuclear region of cytoplasm ACHE, AKR1B1, APP, CA4, EGFR, HSPA1A, PRKCA, PRKCD, PRKCE, PRKCG, SRC, TYR 2.65768
[CC] GO:0044432 endoplasmic reticulum part APP, BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, EGFR, FLT3, HSD11B1, HSD11B2, HSD17B2, PTGS1, PTGS2, TBXAS1 2.41235
[CC] GO:0005783 None ADORA1, APP, BCL2, CA4, CYP19A1, FLT3, HSPA1A, HTR5A, KDR, PRKCA, PRKCD, PRKCE, PTGS2, XDH 2.31075
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, APP, AURKB, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA7, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DUSP3, EGFR, ESR1, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, HTR2A, HTR4, HTR5A, INSR, KDR, MCL1, MIF, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, POLA1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, SMAD3, SRC, TBXAS1, TYR, XDH 2.27652
[CC] GO:0031224 None ACHE, ADORA1, ADORA3, ALPL, APP, AXL, CA12, CA14, CA4, CA9, CNR1, CNR2, CYP3A4, EGFR, ESR1, FLT3, FUT7, GPR35, HCAR2, HSD11B1, HSD17B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MCL1, MET, MPEG1, TBXAS1, TEK, TYR 2.15449
[CC] GO:0016323 basolateral plasma membrane ADORA1, CA2, CA4, CA9, EGFR, TEK 2.05004
[MF] GO:0046914 transition metal ion binding ALOX15, ALOX5, APP, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, ESR1, MMP1, MMP12, MMP2, MMP9, NQO2, PIM1, PPARA, PRKCA, PRKCB, PRKCG, RORC, SMAD3, TBXAS1, TYR, XDH 16.3858
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 16.2108
[MF] GO:0004993 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 16.079
[MF] GO:0099589 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 16.079
[MF] GO:0043176 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 16.079
[MF] GO:0051378 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 16.079
[MF] GO:0043167 ion binding ACHE, ALOX15, ALOX5, ALPL, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, EGFR, ESR1, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, RORC, SMAD3, SRC, TBXAS1, TEK, TYR, XDH 16.079
[MF] GO:0099528 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 13.7534
[MF] GO:0043169 cation binding ACHE, ALOX15, ALOX5, ALPL, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, ESR1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, RORC, SMAD3, TBXAS1, TYR, XDH 11.9942
[MF] GO:0008227 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 11.7371
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DUSP3, EGFR, FLT3, FUT7, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, SRC, TBXAS1, TEK, TYR, XDH 11.5146
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4, EGFR, FLT3, HSPA1A, HTR1B, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK 10.9913
[MF] GO:0042165 neurotransmitter binding ACHE, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 10.5498
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, POLB 10.4914
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.3422
[MF] GO:0070405 ammonium ion binding ACHE, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 9.17575
[MF] GO:0030594 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 8.90207
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AXL, CNR1, CNR2, EGFR, ESR1, FLT3, GPR35, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, PPARA, RORC, TEK 8.37842
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2, NQO2, PTGS1, PTGS2, TBXAS1, TYR, XDH 8.3026
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, PTGS1, PTGS2, SRC, TBXAS1 8.20349
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4 8.13266
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, PTGS1, PTGS2, SRC, TBXAS1 7.87839
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AXL, CNR1, CNR2, EGFR, ESR1, FLT3, GPR35, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, PPARA, PRKCE, RORC, SMAD3, TEK 7.65569
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR1, MMP1, MMP12, MMP2, MMP9, NQO2, PPARA, PRKCA, PRKCB, PRKCG, RORC, SMAD3 7.52061
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK 7.44954
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, PTGS1, PTGS2, TBXAS1, TYR 7.42571
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AXL, CNR1, CNR2, EGFR, ESR1, FLT3, GPR35, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, PPARA, RORC, TEK 7.30312
[MF] GO:0005506 iron ion binding ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, TBXAS1, XDH 7.30145
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, AXL, CNR1, CNR2, EGFR, FLT3, GPR35, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, TEK 7.16359
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, AXL, CNR1, CNR2, EGFR, FLT3, GPR35, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, TEK 7.16359
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK 7.04864
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AXL, CNR1, CNR2, EGFR, ESR1, FLT3, GPR35, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, PPARA, RORC, TEK 7.04555
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 7.03878
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, TBXAS1, TYR 6.93846
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, HSD11B2, HSD17B1, NQO2, POLA1, PTGS1, PTGS2, SRC, TBXAS1, XDH 6.86441
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4 6.81359
[MF] GO:0043560 insulin receptor substrate binding IGF1R, INSR, PIK3CA, PIK3CB, PRKCD 6.786
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, POLB 6.77879
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK 6.77381
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK 6.49256
[MF] GO:0046872 metal ion binding ALOX15, ALOX5, ALPL, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, ESR1, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, RORC, SMAD3, TBXAS1, TYR, XDH 6.47739
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 6.30934
[MF] GO:0004697 None PRKCA, PRKCB, PRKCD, PRKCE, PRKCG 5.93687
[MF] GO:0004713 protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, PRKCD, SRC, TEK 5.78335
[MF] GO:1901363 heterocyclic compound binding ADORA1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, EGFR, ESR1, FLT3, HSD11B2, HSD17B1, HSPA1A, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, IGF1R, INSR, KDR, MET, MMP12, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, RORC, SMAD3, SRC, TBXAS1, TEK, XDH 5.43434
[MF] GO:0097159 organic cyclic compound binding ADORA1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, EGFR, ESR1, FLT3, HSD11B2, HSD17B1, HSPA1A, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, IGF1R, INSR, KDR, MET, MMP12, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, RORC, SMAD3, SRC, TBXAS1, TEK, XDH 5.34576
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4 5.17246
[MF] GO:0004698 None PRKCA, PRKCB, PRKCG 4.42896
[MF] GO:0004930 None ADORA1, ADORA3, CNR1, CNR2, GPR35, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 4.34398
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6, CYP3A4 4.34398
[MF] GO:0036094 small molecule binding ADORA1, AURKB, AXL, CSNK2A1, EGFR, FABP3, FABP4, FLT3, HSD11B2, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, XDH 4.08952
[MF] GO:0000166 nucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSD11B2, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, XDH 3.79083
[MF] GO:1901265 nucleoside phosphate binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSD11B2, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, XDH 3.78846
[MF] GO:0042562 hormone binding ACHE, EGFR, HSD17B1, IGF1R, INSR, NQO2 3.68557
[MF] GO:0005524 ATP binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK 3.64415
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, HSD11B1, HSD11B2, HSD17B1, HSD17B2, XDH 3.62338
[MF] GO:0032559 adenyl ribonucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK 3.51497
[MF] GO:0030554 adenyl nucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK 3.47426
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.3369
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 3.29397
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR 3.29397
[MF] GO:0004674 protein serine/threonine kinase activity AURKB, CSNK2A1, EGFR, NUAK1, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG 3.28634
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.23964
[MF] GO:0009931 None PRKCA, PRKCB, PRKCG 3.04337
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, HSD11B1, HSD11B2, HSD17B1, HSD17B2 2.95711
[MF] GO:0010857 None PRKCA, PRKCB, PRKCG 2.9379
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 2.93541
[MF] GO:0003845 None HSD11B1, HSD11B2 2.93541
[MF] GO:0008389 None CYP2A13, CYP2A6 2.93541
[MF] GO:0035403 None PRKCA, PRKCB 2.93541
[MF] GO:0071886 None HTR2A, HTR2C 2.93541
[MF] GO:0043168 anion binding ALOX15, APP, AURKB, AXL, CSNK2A1, EGFR, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, XDH 2.65768
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, CSNK2A1, EGFR, FLT3, HTR2A, IGF1R, INSR, KDR, MMP12, MMP9, PIM1, PPARA, SMAD3, SRC 2.62715
[MF] GO:0005496 steroid binding CYP3A4, ESR1, HSD11B2, HSD17B1, RORC 2.61527
[MF] GO:0035258 None ESR1, FLT3, PRKCB, SMAD3, SRC 2.57563
[MF] GO:0097367 carbohydrate derivative binding ADORA1, APP, AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK 2.55133
[MF] GO:0035173 histone kinase activity AURKB, PRKCA, PRKCB 2.53385
[MF] GO:0019899 enzyme binding APP, AURKB, BCL2, CYP1A1, CYP1A2, CYP2A6, CYP3A4, DUSP3, EGFR, ESR1, HSPA1A, MET, MIF, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, SMAD3, SRC, TEK 2.53385
[MF] GO:0050473 arachidonate 15-lipoxygenase activity ALOX15, PTGS2 2.53385
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.53385
[MF] GO:0004949 None CNR1, CNR2 2.53385
[MF] GO:0004699 None PRKCD, PRKCE 2.53385
[MF] GO:0035639 purine ribonucleoside triphosphate binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK 2.50003
[MF] GO:0032403 protein complex binding ACHE, ADORA1, EGFR, FLT3, HTR2A, IGF1R, INSR, KDR, MMP12, MMP9, PPARA, SMAD3, SRC 2.45953
[MF] GO:0032555 purine ribonucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK 2.36801
[MF] GO:0017076 purine nucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK 2.33246
[MF] GO:0032553 ribonucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK 2.32341
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.27321
[MF] GO:0051425 None APP, INSR 2.27321
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.27321
[MF] GO:0009055 electron transfer activity AKR1B1, CYP19A1, CYP1A2, NQO2, XDH 2.21662
[MF] GO:0101020 estrogen 16-alpha-hydroxylase activity CYP1A1, CYP3A4 2.08538
[MF] GO:0043559 insulin binding IGF1R, INSR 2.08538
[MF] GO:0051434 BH3 domain binding BCL2, MCL1 2.08538
[MF] GO:0005518 collagen binding ACHE, MMP12, MMP9, SMAD3 2.08538
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX15, ALOX5, PTGS2 2.05004
[MF] GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity EGFR, MET, PIK3CA, PIK3CB 2.01948
[MF] GO:0140096 catalytic activity, acting on a protein AURKB, AXL, CSNK2A1, DUSP3, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK 2.01862
[MF] GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen ALOX15, ALOX5, PTGS2 2.00635


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Serotonergic synapse_Homo sapiens_hsa04726 PRKCG, APP, HTR1E, PRKCB, ALOX15, HTR1D, HTR2B, HTR1A, HTR1B, HTR2C, PRKCA, HTR2A, PTGS2, HTR5A, HTR4, PTGS1, HTR6, HTR7, ALOX5 22.2278
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 17.4798
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 HTR1E, GPR35, HTR1D, HTR2B, HTR1A, HTR1B, HTR2C, HTR2A, HTR5A, HTR4, HTR6, HTR7, CNR2, CNR1, ADORA3, ADORA1 11.2333
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 PRKCG, PIK3CA, PRKCB, SRC, PRKCE, PRKCD, HTR2B, HTR2C, PRKCA, PIK3CB, HTR2A 10.5442
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B1, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 10.4293
Proteoglycans in cancer_Homo sapiens_hsa05205 PRKCG, PRKCB, SRC, MMP2, PRKCA, PIK3CB, MMP9, ESR1, EGFR, IGF1R, PIK3CA, KDR, MET 9.7749
Rap1 signaling pathway_Homo sapiens_hsa04015 PRKCG, PRKCB, SRC, INSR, PRKCA, PIK3CB, EGFR, IGF1R, PIK3CA, CNR1, KDR, TEK, MET 9.6207
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, PIK3CA, PRKCB, MMP2, PRKCE, PRKCD, BCL2, PIM1, PRKCA, PIK3CB 9.2714
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1 9.8928
Pathways in cancer_Homo sapiens_hsa05200 PRKCG, SMAD3, PRKCB, FLT3, MMP1, MMP2, PRKCA, PIK3CB, PTGS2, MMP9, EGFR, IGF1R, PIK3CA, BCL2, MET 8.381
HIF-1 signaling pathway_Homo sapiens_hsa04066 PRKCG, PIK3CA, PRKCB, INSR, BCL2, PRKCA, TEK, PIK3CB, EGFR, IGF1R 9.2311
Ras signaling pathway_Homo sapiens_hsa04014 PRKCG, HTR7, PIK3CA, PRKCB, INSR, KDR, PRKCA, TEK, PIK3CB, MET, EGFR, IGF1R 8.2779
VEGF signaling pathway_Homo sapiens_hsa04370 PRKCG, PIK3CA, PRKCB, SRC, KDR, PRKCA, PIK3CB, PTGS2 8.3714
Calcium signaling pathway_Homo sapiens_hsa04020 PRKCG, HTR6, HTR7, PRKCB, HTR2B, HTR2C, PRKCA, HTR2A, HTR5A, HTR4, EGFR 8.2258
MicroRNAs in cancer_Homo sapiens_hsa05206 PRKCG, PRKCB, PRKCE, PRKCA, PTGS2, MMP9, EGFR, PIK3CA, BCL2, PIM1, CYP1B1, MET, MCL1 8.1045
Estrogen signaling pathway_Homo sapiens_hsa04915 PIK3CA, SRC, MMP2, PRKCD, PIK3CB, MMP9, ESR1, EGFR, HSPA1A 8.1729
cAMP signaling pathway_Homo sapiens_hsa04024 HCAR2, HTR6, PIK3CA, HTR1E, HTR1D, ADORA1, HTR1A, HTR1B, PIK3CB, PPARA, HTR4 7.8425
Focal adhesion_Homo sapiens_hsa04510 PRKCG, PIK3CA, PRKCB, SRC, KDR, BCL2, PRKCA, PIK3CB, MET, EGFR, IGF1R 7.7972
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 PRKCG, HSD11B2, PIK3CA, PRKCB, INSR, PRKCA, PIK3CB 8.2779
Sphingolipid signaling pathway_Homo sapiens_hsa04071 PRKCG, PIK3CA, PRKCB, ADORA3, PRKCE, BCL2, ADORA1, PRKCA, PIK3CB 7.5432
Hepatitis B_Homo sapiens_hsa05161 PRKCG, SMAD3, PIK3CA, PRKCB, SRC, BCL2, PRKCA, PIK3CB, MMP9 6.8693
Glioma_Homo sapiens_hsa05214 PRKCG, PIK3CA, PRKCB, PRKCA, PIK3CB, EGFR, IGF1R 6.9245
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, PTGS2, CYP3A4 7.5436
Gap junction_Homo sapiens_hsa04540 PRKCG, PRKCB, SRC, HTR2B, HTR2C, PRKCA, HTR2A, EGFR 7.3577
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PIK3CA, INSR, ADORA1, PIK3CB, PTGS2, PTGS1 7.3577
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 PIK3CA, INSR, KDR, BCL2, PRKCA, TEK, PIK3CB, MET, EGFR, MCL1, IGF1R 5.679
Metabolic pathways_Homo sapiens_hsa01100 ALOX15, AKR1B1, PTGS2, TYR, CYP3A4, CYP19A1, PTGS1, HSD11B1, POLA1, CYP2A6, FUT7, AKR1B10, ALOX5, HSD17B1, TBXAS1, HSD17B2, CYP1A2, CYP1A1, ALPL, XDH 5.5969
ErbB signaling pathway_Homo sapiens_hsa04012 PRKCG, PIK3CA, PRKCB, SRC, PRKCA, PIK3CB, EGFR 6.1023
Adherens junction_Homo sapiens_hsa04520 SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R 6.5774
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, CYP3A4 6.6026
Oxytocin signaling pathway_Homo sapiens_hsa04921 PRKCG, PIK3CA, PRKCB, SRC, PRKCA, PIK3CB, PTGS2, EGFR 5.5281
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PRKCG, PIK3CA, PRKCB, PRKCE, PRKCD, PRKCA, PIK3CB 5.9318
Cholinergic synapse_Homo sapiens_hsa04725 PRKCG, ACHE, PIK3CA, PRKCB, BCL2, PRKCA, PIK3CB 5.4726
Insulin resistance_Homo sapiens_hsa04931 PIK3CA, PRKCB, INSR, PRKCE, PRKCD, PIK3CB, PPARA 5.5139
Non-small cell lung cancer_Homo sapiens_hsa05223 PRKCG, PIK3CA, PRKCB, PRKCA, PIK3CB, EGFR 5.9481
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 PRKCG, PIK3CA, PRKCB, SRC, PRKCA, PIK3CB, ESR1 5.3285
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PRKCG, PIK3CA, PRKCB, MMP2, PRKCA, PIK3CB, MMP9 5.3285
Tight junction_Homo sapiens_hsa04530 PRKCG, CSNK2A1, PRKCB, SRC, PRKCE, PRKCD, PRKCA 4.8847
GnRH signaling pathway_Homo sapiens_hsa04912 PRKCB, SRC, MMP2, PRKCD, PRKCA, EGFR 4.8511
Choline metabolism in cancer_Homo sapiens_hsa05231 PRKCG, PIK3CA, PRKCB, PRKCA, PIK3CB, EGFR 4.5979
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, PIK3CA, INSR, PIK3CB, EGFR, IGF1R 3.9714
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 PIK3CA, ADORA3, INSR, PRKCE, ADORA1, PIK3CB 3.4712
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KDR, MET, EGFR, IGF1R, HSPA1A 3.301
Prostate cancer_Homo sapiens_hsa05215 PIK3CA, BCL2, PIK3CB, EGFR, IGF1R 3.7572
mTOR signaling pathway_Homo sapiens_hsa04150 PRKCG, PIK3CA, PRKCB, PRKCA, PIK3CB 4.5381
Melanoma_Homo sapiens_hsa05218 PIK3CA, PIK3CB, MET, EGFR, IGF1R 4.2155
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PRKCG, PIK3CA, PRKCB, PRKCA, PIK3CB 3.5743
Amoebiasis_Homo sapiens_hsa05146 PRKCG, PIK3CA, PRKCB, PRKCA, PIK3CB 3.5408
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 PRKCG, PRKCB, CNR1, PRKCA, PTGS2 3.5284
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 PIK3CA, INSR, PIK3CB, IGF1R, HSPA1A 4.4186
Central carbon metabolism in cancer_Homo sapiens_hsa05230 PIK3CA, FLT3, PIK3CB, MET, EGFR 4.3298
Toxoplasmosis_Homo sapiens_hsa05145 PIK3CA, ALOX5, BCL2, PIK3CB, HSPA1A 3.256
Platelet activation_Homo sapiens_hsa04611 PIK3CA, SRC, TBXAS1, PIK3CB, PTGS1 3.2165
Vascular smooth muscle contraction_Homo sapiens_hsa04270 PRKCG, PRKCB, PRKCE, PRKCD, PRKCA 3.2336
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, ALOX15, TBXAS1, PTGS2, PTGS1 4.4772
Type II diabetes mellitus_Homo sapiens_hsa04930 PIK3CA, INSR, PRKCE, PRKCD, PIK3CB 4.9821
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 PRKCG, PIK3CA, PRKCB, PRKCA, PIK3CB 3.0457
Wnt signaling pathway_Homo sapiens_hsa04310 PRKCG, SMAD3, CSNK2A1, PRKCB, PRKCA 2.9574
Phospholipase D signaling pathway_Homo sapiens_hsa04072 PIK3CA, INSR, PRKCA, PIK3CB, EGFR 2.9378
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIK3CA, BCL2, PIM1, PIK3CB, MCL1 2.7878
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9, EGFR 5.319
MAPK signaling pathway_Homo sapiens_hsa04010 PRKCG, DUSP3, PRKCB, PRKCA, EGFR, HSPA1A 2.6751
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.246
Alzheimer's disease_Homo sapiens_hsa05010 APP 0.2709
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.2961
Long-term depression_Homo sapiens_hsa04730 PRKCG, PRKCB, PRKCA, IGF1R 3.3322
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.3346
Influenza A_Homo sapiens_hsa05164 PIK3CA, PRKCB, PRKCA, PIK3CB, HSPA1A 2.6413
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, PIK3CA, BCL2, PIK3CB, HSPA1A 2.3916
Acute myeloid leukemia_Homo sapiens_hsa05221 PIK3CA, FLT3, PIM1, PIK3CB 3.4115
Axon guidance_Homo sapiens_hsa04360 MET 0.3492
Cell cycle_Homo sapiens_hsa04110 SMAD3 0.3544
Prolactin signaling pathway_Homo sapiens_hsa04917 PIK3CA, SRC, PIK3CB, ESR1 3.096
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.3544
Gastric acid secretion_Homo sapiens_hsa04971 PRKCG, PRKCB, CA2, PRKCA 3.0568
Pancreatic cancer_Homo sapiens_hsa05212 SMAD3, PIK3CA, PIK3CB, EGFR 3.2165
Colorectal cancer_Homo sapiens_hsa05210 SMAD3, PIK3CA, BCL2, PIK3CB 3.2917
Chemokine signaling pathway_Homo sapiens_hsa04062 PIK3CA, PRKCB, SRC, PRKCD, PIK3CB 2.5237
Aldosterone synthesis and secretion_Homo sapiens_hsa04925 PRKCG, PRKCB, PRKCE, PRKCA 2.9378
Taste transduction_Homo sapiens_hsa04742 HTR1E, HTR1D, HTR1A, HTR1B 2.9094
Pyrimidine metabolism_Homo sapiens_hsa00240 POLA1 0.4045
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4151
Purine metabolism_Homo sapiens_hsa00230 POLA1, XDH 0.6609
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4337
Morphine addiction_Homo sapiens_hsa05032 PRKCG, PRKCB, ADORA1, PRKCA 2.7812
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 PIK3CA, SRC, PIK3CB, MET 2.9821
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2, HSPA1A 0.6851
TNF signaling pathway_Homo sapiens_hsa04668 PIK3CA, PIK3CB, PTGS2, MMP9 2.5265
Melanogenesis_Homo sapiens_hsa04916 PRKCG, PRKCB, PRKCA, TYR 2.6613
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.6564
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 PIK3CA, INSR, PIK3CB, IGF1R 2.7445
GABAergic synapse_Homo sapiens_hsa04727 PRKCG, PRKCB, SRC, PRKCA 2.8248
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.4552
Neurotrophin signaling pathway_Homo sapiens_hsa04722 PIK3CA, PRKCD, BCL2, PIK3CB 2.4026
Hepatitis C_Homo sapiens_hsa05160 PIK3CA, PIK3CB, PPARA, EGFR 2.2548
Small cell lung cancer_Homo sapiens_hsa05222 PIK3CA, BCL2, PIK3CB, PTGS2 2.8567
Measles_Homo sapiens_hsa05162 CSNK2A1, PIK3CA, PIK3CB, HSPA1A 2.2336
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1, CYP3A4 3.2336
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.469
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4538
AMPK signaling pathway_Homo sapiens_hsa04152 PIK3CA, INSR, PIK3CB, IGF1R 2.3601
Apoptosis_Homo sapiens_hsa04210 PIK3CA, BCL2, PIK3CB, MCL1 2.2061
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, PRKCB, BCL2, PTGS2 2.7565
Peroxisome_Homo sapiens_hsa04146 XDH 0.4706
Pancreatic secretion_Homo sapiens_hsa04972 PRKCG, PRKCB, CA2, PRKCA 2.7156
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.154
Osteoclast differentiation_Homo sapiens_hsa04380 PIK3CA, PIK3CB 0.8374
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 1.37
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.495
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, PIK3CA, PIK3CB, IGF1R 2.1925
HTLV-I infection_Homo sapiens_hsa05166 POLB, SMAD3, PIK3CA, PIK3CB 1.4032
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.8722
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 PRKCG, PRKCB, PRKCA, ESR1 3.7014
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 PIK3CA, BCL2, PRKCA, PIK3CB 2.145
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 PIK3CA, PIK3CB 0.9846
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5272
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 PIK3CA, SRC, PIK3CB, EGFR 1.6523
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PIK3CA, INSR, PIK3CB, PPARA 2.1222
Viral carcinogenesis_Homo sapiens_hsa05203 POLB, PIK3CA, SRC, PIK3CB 1.7071
T cell receptor signaling pathway_Homo sapiens_hsa04660 PIK3CA, PIK3CB 0.9957
Insulin signaling pathway_Homo sapiens_hsa04910 PIK3CA, INSR, PIK3CB 1.4655
Shigellosis_Homo sapiens_hsa05131 SRC 0.5521
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.555
Dopaminergic synapse_Homo sapiens_hsa04728 PRKCG, PRKCB, PRKCA 1.5461
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1, TEK 1.098
Glutamatergic synapse_Homo sapiens_hsa04724 PRKCG, PRKCB, PRKCA 1.6807
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PIK3CA, PIK3CB, IGF1R 1.8392
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3, PIK3CA, PIK3CB 1.7802
Circadian entrainment_Homo sapiens_hsa04713 PRKCG, PRKCB, PRKCA 1.87
Legionellosis_Homo sapiens_hsa05134 HSPA1A 0.6096
Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 PRKCA 0.6096
Salivary secretion_Homo sapiens_hsa04970 PRKCG, PRKCB, PRKCA 1.9344
Insulin secretion_Homo sapiens_hsa04911 PRKCG, PRKCB, PRKCA 1.9855
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.633
Vibrio cholerae infection_Homo sapiens_hsa05110 PRKCA 0.633
Leishmaniasis_Homo sapiens_hsa05140 PRKCB, PTGS2 1.2534
Malaria_Homo sapiens_hsa05144 MET 0.6428
Bile secretion_Homo sapiens_hsa04976 CA2, CYP3A4 1.2719
Inositol phosphate metabolism_Homo sapiens_hsa00562 PIK3CA, PIK3CB 1.2719
Chronic myeloid leukemia_Homo sapiens_hsa05220 SMAD3, PIK3CA, PIK3CB 2.1537
B cell receptor signaling pathway_Homo sapiens_hsa04662 PIK3CA, PRKCB, PIK3CB 2.1537
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 PIK3CA, PRKCA, PIK3CB 2.2155
Long-term potentiation_Homo sapiens_hsa04720 PRKCG, PRKCB, PRKCA 2.2346
Renal cell carcinoma_Homo sapiens_hsa05211 PIK3CA, PIK3CB, MET 2.2346
Amphetamine addiction_Homo sapiens_hsa05031 PRKCG, PRKCB, PRKCA 2.225
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 2.2155
Thyroid hormone synthesis_Homo sapiens_hsa04918 PRKCG, PRKCB, PRKCA 2.1795
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, CYP1A2, CYP3A4 2.2061
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3, RORC 1.335
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.4032
Endometrial cancer_Homo sapiens_hsa05213 PIK3CA, PIK3CB, EGFR 2.5033
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.761
DNA replication_Homo sapiens_hsa03030 POLA1 0.7528
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8038
Base excision repair_Homo sapiens_hsa03410 POLB 0.7817
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.8511
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 PIK3CA, PRKCB, PIK3CB 2.6613
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, CYP3A4, XDH 2.6413
African trypanosomiasis_Homo sapiens_hsa05143 PRKCG, PRKCB, PRKCA 2.9179
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8601
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1 2.7802
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.8142
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8511
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2, CYP3A4 3.113
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.9129
Tyrosine metabolism_Homo sapiens_hsa00350 MIF, TYR 1.8022
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.87
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.7823
Phenylalanine metabolism_Homo sapiens_hsa00360 MIF 1.0265
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.1239
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.1015
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 5.3785


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)