Component: Pharbitis nil 牵牛子


Description of the Component

Component ID
TCMH1662
Latin Name
Pharbitis nil
English Name
Lobedleaf pharbitis seed
Chinese Pinyin Name
Qian Niu Zi
中文名
牵牛子
TCM Properties
Cold,Bitter
TCM Meridians
Lung,Large Intestine,Kidney
Therapeutic Class English
Purging
Therapeutic Class Chinese
泻下
Functions
cause drastic purgation for clearing away retained fluid, and kill worms
Toxicity
Extremely Toxic
Geo-authentic habitats (道地产区)
NA
Reference
Chinese Pharmacopoeia (2015)
Barcode ID
Barcode Source

TCM Prescriptions with the Component

Prescription ID Prescription English Name Prescription Chinese Name
TCMF1373 Aucklandiae and Arecae Pills 木香槟榔丸
TCMFx3757 Bing Lang Si Xiao Tablets 槟榔四消片
TCMFx1281 Binglang Sixiao Pills, Digestion Pill of Betel Nut 槟榔四消丸
TCMFx1872 Binglang Sixiao Pills, Digestion Pill of Betel Nut 槟榔四消丸
TCMF3155 Chen Xiang Hua Zhi Pills 沉香化滞丸
TCMF3170 Chen Xiang Li Qi Pills 沉香利气丸
TCMFx1683 Children's Indigestion Powder 一捻金
TCMFx2274 Dahuang Qingwei Pills 大黄清胃丸
TCMFx1368 Dahuang Qingwei Pills 大黄清胃丸
TCMFx3247 Di Tan Pills 涤痰丸
TCMFx3303 Dian Xian Ning Tablets 癫痫宁片
TCMFx3201 Fei Er Gan Ji Granules 肥儿疳积颗粒
TCMF3823 Fu Fang Niu Huang Qing Wei Pills 复方牛黄清胃丸
TCMF795 Fu Fang Niu Huang Qing Wei Pills 复方牛黄清胃丸
TCMF4749 Hu Po Li Qi Pills 琥珀利气丸
TCMFx4880 Hua Chong Pills 化虫丸
TCMFx4903 Hua Ji Powder 化积散
TCMF4417 Huo Xue Pills 活血丸
TCMFx4761 Jia Wei Lan Ji Pills 加味烂积丸
TCMF4811 Jia Wei Si Xiao Pills 加味四消丸
TCMF4302 Jian Shen Xiao Dao Infusion 健身消导冲剂
TCMFx4596 Jiao Zha Hua Zhi Pills 焦楂化滞丸
TCMFx4606 Jiu Jing Powder 救惊散
TCMFx4836 Kai Xiong Li Qi Pills 开胸理气丸
TCMFx253 Kai Xiong Shun Qi Capsule 开胸顺气胶囊
TCMF4851 Kai Yu Lao Kou Pills 开郁老蔻丸
TCMFx1998 Kaixiong Shunqi Pills 开胸顺气丸
TCMFx1308 Kaixiong Shunqi Pills; Digestion-Promoting Pill 开胸顺气丸
TCMFx4569 Kuan Xiong Shu Qi Hua Zhi Pills 宽胸舒气化滞丸
TCMFx4581 Kuan Zhong Shun Qi Pills 宽中顺气丸
TCMF4767 Lan Ji Pills 烂积丸
TCMF4799 Lao Kou Pills 老蔻丸
TCMF4586 Liu Yu Pills 六郁丸
TCMF4620 Mu Xiang Li Qi Tablets 木香理气片
TCMF4236 Niu Huang Qing Wei Pills 牛黄清胃丸
TCMF4556 Pi Shen Liang Zhu Pills 脾肾两助丸
TCMF2330 Pills of Aucklandiae and Arecae 木香槟榔丸
TCMFx5071 Qian Qu 黔曲
TCMF5643 Qing Re Shen Xiong Pills 清热神芎丸
TCMFx5683 Qing Re Yi Zhi Powder 清热异滞散
TCMF5754 Qing Wei He Zhong Pills 清胃和中丸
TCMFx5770 Qing Wei Pills 清胃丸
TCMFx5806 Qing Xin Gun Tan Pills 清心滚痰丸
TCMFx5050 Qu Chong Tablets 驱虫片
TCMFx5056 Qu Chong Xiao Shi Tablets 驱虫消食片
TCMFx5361 Sha Chong Pills 杀虫丸
TCMFx5518 Shan Zha Hua Zhi Pills 山楂化滞丸
TCMFx5544 Shan Zha Mai Qu Granules 山楂麦曲颗粒
TCMFx1280 Shanzha Huazhi Pills 山楂化滞丸
TCMFx1866 Shanzha Huazhi Pills 山楂化滞丸
TCMF5032 Shi Xiang Ding Tong Pills 十香定痛丸
TCMF5335 Shu Gan Diao Qi Pills 舒肝调气丸
TCMF5285 Shu Gan Jian Wei Infusion 舒肝健胃冲剂
TCMF5292 Shu Gan Jian Wei Pills 舒肝健胃丸
TCMF5486 Shu Qi Pills 舒气丸
TCMFx6993 Si Bai Qu Ban Ruan Ointment 丝白祛斑软膏
TCMFx5979 Si Xiao Pills 四消丸
TCMF5674 Tiao Jing Zhi Bao Pills 调经至宝丸
TCMFx5731 Tiao Zhong Si Xiao Pills 调中四消丸
TCMFx5747 Tie Ji Ointment 贴积膏
TCMF5332 Wan Ling Jin Gu Ointment 万灵筋骨膏
TCMFx5477 Wu Jia Pills 五瘕丸
TCMFx5596 Wu Xiang Pills 五香丸
TCMFx6717 Xiao Er Hua Shi Pills 小儿化食丸
TCMFx6741 Xiao Er Hua Zhi Powder 小儿化滞散
TCMFx237 Xiao Er Hua Shi Oral Liquid 小儿化食口服液
TCMFx238 Xiao Er Hua Shi Pills 小儿化食丸
TCMFx6755 Xiao Er Ji Powder 小儿积散
TCMF6425 Xiao Er Xiao Ji Pills 小儿消积丸
TCMFx6595 Xiao Er Zhu Huang Powder 小儿珠黄散
TCMF6078 Xiao Ji Hua Chong Capsules 消积化虫胶囊
TCMF6086 Xiao Ji Hua Chong Powder 消积化虫散
TCMF6094 Xiao Ji Hua Chong Syrup 消积化虫糖浆
TCMFx6102 Xiao Ji Hua Zhi Tablets 消积化滞片
TCMF6126 Xiao Ji Pills 消积丸
TCMFx6327 Xiao Shui Dao Zhi Pills 消水导滞丸
TCMF176 Yi Nian Jin Capsule 一捻金胶囊
TCMFx6232 Ying Er Xiao Shi Powder 婴儿消食散
TCMFx1244 Yinianjin Powder for Infants; Children's Indigestion Powder 一捻金
TCMFx6316 Zhou Che Pills 舟车丸
TCMF2252 Zhouju Pill

Targeted Human Proteins by the Ingredient of Component

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT1 EHMT2 Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 Transferase Q96KQ7
TCMT11 HIF1A Hypoxia-inducible factor 1 alpha Transcription factor Q16665
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT31 CYP2C19 Cytochrome P450 2C19 Oxidoreductase P33261
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT34 CYP2D6 Cytochrome P450 2D6 Oxidoreductase P10635
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT565 EP300 Histone acetyltransferase p300 Transferase Q09472
TCMT678 XIAP Inhibitor of apoptosis protein 3 Transferase P98170
TCMT679 MPEG1 Macrophage-expressed gene 1 protein Unclassified Q2M385
TCMT680 KAT2B Histone acetyltransferase PCAF Transferase Q92831
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT80 MAPK1 MAP kinase ERK2 Kinase P28482
TCMT81 ALOX12 Arachidonate 12-lipoxygenase Oxidoreductase P18054
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712


Targeted Pathogenic Microbes by the Ingredient of Component

Target ID Target Name
TCMT1223 Staphylococcus epidermidis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1463 Mycobacterium tuberculosis

Ingredient Structrues

Ingredient ID: TCMC5934
Formula: C5H10O3

Ingredient ID: TCMC5924
Formula: C16H18N2O2

Ingredient ID: TCMC4379
Formula: C19H22O5

Ingredient ID: TCMC4332
Formula: C16H20N2O

Ingredient ID: TCMC4286
Formula: C19H24O5

Ingredient ID: TCMC3822
Formula: C16H18N2O

Ingredient ID: TCMC3411
Formula: C16H18N2O2

Ingredient ID: TCMC2950
Formula: C5H10O2

Ingredient ID: TCMC2528
Formula: C18H13NO3

Ingredient ID: TCMC212
Formula: C16H18N2O

Ingredient ID: TCMC1104
Formula: C17H26O4

Properties

Ingredient ID Formulae Name MW AlogP MlogP XlogP # HBA # HBD PSA # Rotatable Bond # Ring # Heacy Atom Lipinski RO5 Violation
TCMC212 C16H18N2O [(6As,9R)-7-Methyl-6,6A,8,9-Tetrahydro-4H-Indolo[4,3-Fg]Quinoline-9-Yl]Methanol 254.14 -0.7639 2.89 1.33 3 2 39.26 3 4 19 0
TCMC1104 C17H26O4 Embelin 294.18 -3.4988 2.89 6.234 4 2 74.6 13 1 21 1
TCMC2528 C18H13NO3 Lysicamine 291.09 -0.3674 3 3.348 2 0 48.42 4 4 22 0
TCMC2950 C5H10O2 Pentanic Acid,Scopolin 101.0602545 -1.4075 1.79 0.83 2 0 40.13 3 0 7 0
TCMC3411 C16H18N2O2 Penniclavine 271.1446528 -2.6601 2.78 0.224 3 4 60.69 1 4 20 0
TCMC3822 C16H18N2O Elymoclavine 255.1497382 -1.9492 2.89 0.939 2 3 40.46 1 4 19 0
TCMC4286 C19H24O5 Gibberellin A20 331.1545488 -0.6158 3 0.245 5 1 86.66 1 5 24 0
TCMC4332 C16H20N2O Chanoclavine 257.1653883 -1.3188 2.89 1.509 2 3 52.63 3 3 19 0
TCMC4379 C19H22O5 Gibberellin A5 329.1388988 -0.1156 3 0.348 5 1 86.66 1 5 24 0
TCMC5924 C16H18N2O2 Isopenniclavine 271.1446528 -2.6601 2.78 0.224 3 4 60.69 1 4 20 0
TCMC5934 C5H10O3 Nilic Acid 117.0551691 -1.0822 1.68 -0.687 3 1 60.36 2 0 8 0

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1. General Information of the Component  
2. TCM Prescriptions with the Component  
3. Putative Targets  
4. Activity & References for Filtering Putative Targets  
5. Ingredient Data & Chemical Structure Information (Properties, InChI, InChIkey, SMILES, etc.)