TCM Prescription: Xiao Ji Pills



Prescription Description
Prescription IDTCMF6126
Pinyin NameXiao Ji Wan
Chinese Name消积丸
English NameXiao Ji Pills
Function Description积滞
IndicationsDyspepsia
Disease ICD-11 Category MD92 [Dyspepsia, 消化不良 ];
Human Tissues Associated with IndicationSpleen, Intestine, Stomach
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH363 Rheum officinale 大黄 TCMH363 ITSAJ4685-14
TCMH1662 Pharbitis nil 牵牛子 TCMH1662
TCMH1848 Crataegus pinnatifida 山楂 TCMH1848 ITSAH1684-14
TCMH1307 Massa medicata fermentata 六神曲 TCMH1307
TCMH1430 Hordeum vulgare 麦芽 TCMH1430 ITSAI3101-14
TCMH2188 Trogopterus xanthipes 五灵脂 TCMH2188
TCMH1695 Pericarpium citri reticulatae viride 青皮 TCMH1695
TCMH243 Pericarpium citri reticulatae 陈皮 TCMH243
TCMH1766 Sparganium stoloniferum 三棱 TCMH1766 ITSAJ4240-14
TCMH544 Curcuma aeruginosa 莪术 TCMH544 ITSAN2146-14
TCMH2265 Cyperus rotundus 香附 TCMH2265 GENG1049-15
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT114 CNR2 Cannabinoid CB2 receptor GPCR P34972
TCMT115 CNR1 Cannabinoid CB1 receptor GPCR P21554
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT160 HTR7 Serotonin 7 (5-HT7) receptor GPCR P34969
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT313 HTR2B Serotonin 2b (5-HT2b) receptor GPCR P41595
TCMT314 HTR2C Serotonin 2c (5-HT2c) receptor GPCR P28335
TCMT315 HTR6 Serotonin 6 (5-HT6) receptor GPCR P50406
TCMT318 HKDC1 Putative hexokinase HKDC1 Transferase Q2TB90
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT335 MPO Myeloperoxidase Oxidoreductase P05164
TCMT336 IDO1 Indoleamine 2,3-dioxygenase Oxidoreductase P14902
TCMT36 HTR1A Serotonin 1a (5-HT1a) receptor GPCR P08908
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT37 HTR2A Serotonin 2a (5-HT2a) receptor GPCR P28223
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT508 SYK Tyrosine-protein kinase SYK Kinase P43405
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT645 HTR1E Serotonin 1e (5-HT1e) receptor GPCR P28566
TCMT646 HTR5A Serotonin 5a (5-HT5a) receptor GPCR P47898
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT678 XIAP Inhibitor of apoptosis protein 3 Transferase P98170
TCMT679 MPEG1 Macrophage-expressed gene 1 protein Unclassified Q2M385
TCMT680 KAT2B Histone acetyltransferase PCAF Transferase Q92831
TCMT729 PIK3CA PI3-kinase p110-alpha subunit Transferase P42336
TCMT730 PIK3CB PI3-kinase p110-beta subunit Transferase P42338
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT815 HTR1D Serotonin 1d (5-HT1d) receptor GPCR P28221
TCMT816 HTR1B Serotonin 1b (5-HT1b) receptor GPCR P28222
TCMT817 HTR4 Serotonin 4 (5-HT4) receptor GPCR Q13639
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1180 Human herpesvirus 2
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1183 Candida albicans SC5314
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1201 Staphylococcus epidermidis ATCC 12228
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1284 Penicillium expansum
TCMT1285 Human coxsackievirus B3
TCMT1286 Bacillus cereus
TCMT1292 Japanese encephalitis virus
TCMT1294 Human parainfluenza virus 3
TCMT1297 Punta Toro virus
TCMT1318 Human T-lymphotropic virus 1
TCMT1321 Staphylococcus hominis
TCMT1336 Yellow fever virus
TCMT1337 Dengue virus type 4
TCMT1338 Rift Valley fever virus
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1353 Plasmodium yoelii
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0007210 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 17.3156
[BP] GO:0098664 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 17.3156
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CNR1, CNR2, CYP1A1, CYP1A2, ESR1, FABP3, FLT3, HSD11B2, HSD17B2, HTR1B, HTR5A, IDO1, MPO, PTGS2, RORC, SRC, TYR 11.4158
[BP] GO:0065008 regulation of biological quality ACHE, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA12, CA2, CA7, CNR1, CNR2, CYP19A1, CYP1A1, CYP1B1, ESR1, FABP3, FABP4, FLT3, HCAR2, HSD11B1, HSD11B2, HSD17B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR4, HTR7, KDR, MET, PIK3CA, PIK3CB, PTGS1, PTGS2, SRC, TNKS, TNKS2, XDH 10.7853
[BP] GO:0042221 response to chemical AKR1B1, ALOX15, ALPL, AXL, BCL2, CA2, CA9, CNR1, CNR2, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR5A, IDO1, IGF1R, KDR, MMP2, MMP9, MPO, PIK3CA, PTGS2, RORC, SRC, TYR 10.7461
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, AXL, BCL2, CA9, CNR1, CNR2, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, HSD11B2, HSD17B2, HTR1B, HTR5A, IDO1, IGF1R, MMP2, MMP9, MPO, PIK3CA, PTGS2, RORC, SRC, TYR 10.2745
[BP] GO:0010033 response to organic substance AKR1B1, ALOX15, ALPL, AXL, BCL2, CA2, CA9, CNR1, CNR2, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, HTR1B, HTR5A, IDO1, IGF1R, KDR, MMP2, MPO, PIK3CA, PTGS2, RORC, SRC, TYR 9.22491
[BP] GO:0032501 multicellular organismal process AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AXL, BCL2, CNR1, CNR2, CYP19A1, CYP1A2, CYP1B1, ESR1, FABP4, HSD11B2, HSD17B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR7, IDO1, IGF1R, MET, MMP1, MMP2, MMP9, MPO, PIK3CA, PIM1, PTGS2, RORC, SRC, TNKS2, TYR 8.15143
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX15, ALOX5, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FUT7, HTR2B, HTR2C, IDO1, MPO, PIK3CA, PIM1, PTGS1, PTGS2, TYR, XDH 7.53384
[BP] GO:0007187 None CHRM2, CNR1, CNR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR4, HTR5A, HTR6, HTR7 7.52184
[BP] GO:0097756 None HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 7.28092
[BP] GO:0032844 regulation of homeostatic process AURKB, BCL2, CA2, CA7, CNR1, HCAR2, HTR2A, HTR2B, HTR2C, KDR, PIK3CB, PTGS2, SRC, TNKS, TNKS2 7.28092
[BP] GO:0010647 positive regulation of cell communication AKR1B1, ALOX15, AXL, BCL2, CA2, CA7, CYP19A1, CYP1B1, FLT3, HCAR2, HTR2A, HTR2B, HTR2C, HTR6, KDR, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 7.19084
[BP] GO:0023056 positive regulation of signaling AKR1B1, ALOX15, AXL, BCL2, CA2, CA7, CYP19A1, CYP1B1, FLT3, HCAR2, HTR2A, HTR2B, HTR2C, HTR6, KDR, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 7.18246
[BP] GO:0007198 None HTR1A, HTR1B, HTR5A, HTR7 7.01798
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.9729
[BP] GO:0014070 response to organic cyclic compound ALPL, BCL2, CA2, CA9, CNR1, CYP1A1, CYP1A2, CYP1B1, ESR1, FLT3, HSD11B2, HTR1B, HTR5A, PTGS2, RORC, SRC, TYR 6.69928
[BP] GO:0042493 response to drug AKR1B1, AXL, BCL2, CA9, CNR1, CNR2, CYP1A1, CYP1B1, FABP3, HSD11B2, HTR1B, HTR2A, HTR2B, HTR2C, KDR, PTGS2, SRC 6.62587
[BP] GO:0006629 lipid metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FUT7, HSD11B1, HSD11B2, HSD17B2, MET, PIK3CA, PIK3CB, PTGS1, PTGS2 6.62587
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, TYR 6.5537
[BP] GO:0042310 None HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7 6.43933
[BP] GO:0043067 regulation of programmed cell death AKR1B1, AURKB, AXL, BCL2, CNR1, CYP1B1, ESR1, FLT3, HCAR2, HTR2B, IDO1, IGF1R, KDR, MET, MMP9, MPO, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, XDH 6.42839
[BP] GO:0050896 response to stimulus ACHE, ADORA3, AKR1B1, ALOX15, ALPL, AURKB, AXL, BCL2, CA2, CA9, CHRM2, CNR1, CNR2, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR5A, IDO1, IGF1R, KDR, MMP2, MMP9, MPO, PIK3CA, PIK3CB, PTGS1, PTGS2, PTPN1, RORC, SRC, TYR 6.35698
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B1, HSD11B2, HSD17B2, IDO1, MPO, NQO2, PTGS1, PTGS2, TYR, XDH 6.32108
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA3, CA2, CHRM2, CNR1, CNR2, ESR1, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, PIK3CA, PIK3CB, SRC 6.24006
[BP] GO:0010817 regulation of hormone levels ACHE, AKR1B1, CNR1, CYP19A1, CYP1A1, CYP1B1, ESR1, HCAR2, HSD11B1, HSD11B2, HSD17B2, HTR1A, HTR2A, HTR2C 6.10057
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 5.96551
[BP] GO:0010646 regulation of cell communication ACHE, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CNR1, CNR2, CYP19A1, CYP1B1, ESR1, FLT3, HCAR2, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 5.96372
[BP] GO:0010941 regulation of cell death AKR1B1, AURKB, AXL, BCL2, CNR1, CYP1B1, ESR1, FLT3, HCAR2, HTR2B, IDO1, IGF1R, KDR, MET, MMP9, MPO, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, XDH 5.92995
[BP] GO:0042981 regulation of apoptotic process AKR1B1, AURKB, AXL, BCL2, CNR1, CYP1B1, ESR1, FLT3, HCAR2, HTR2B, IDO1, IGF1R, KDR, MMP9, MPO, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, XDH 5.8743
[BP] GO:0023051 regulation of signaling ACHE, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CNR1, CNR2, CYP19A1, CYP1B1, ESR1, FLT3, HCAR2, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 5.85942
[BP] GO:1902533 positive regulation of intracellular signal transduction AKR1B1, ALOX15, AXL, BCL2, CYP1B1, FLT3, HTR2A, HTR2B, HTR2C, HTR6, KDR, MET, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 5.84188
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, MMP9, PTGS2, SRC 5.68106
[BP] GO:0048522 positive regulation of cellular process ACHE, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CNR1, CYP19A1, CYP1A1, CYP1B1, ESR1, FABP3, FLT3, HCAR2, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IDO1, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, XDH 5.60493
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, SRC 5.57164
[BP] GO:0007193 None CHRM2, HTR1A, HTR1B, HTR1D, HTR1E, HTR5A, HTR7 5.56246
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, BCL2, CNR1, CNR2, CYP1A1, CYP1B1, HTR1B, HTR1D, KDR, SRC 5.38989
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B2 5.37592
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B2 5.31977
[BP] GO:0042127 regulation of cell proliferation ADORA3, AKR1B1, BCL2, CDC25B, CYP1B1, ESR1, FABP3, FLT3, HTR1A, HTR1B, HTR2A, HTR2B, IDO1, IGF1R, KDR, MMP2, MMP9, PIM1, PTGS1, PTGS2, SRC, XDH 5.31977
[BP] GO:0071073 None FABP3, HTR2A, HTR2B, HTR2C 5.28502
[BP] GO:0009967 positive regulation of signal transduction AKR1B1, ALOX15, AXL, BCL2, CYP1B1, FLT3, HTR2A, HTR2B, HTR2C, HTR6, KDR, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 5.17963
[BP] GO:0048584 positive regulation of response to stimulus AKR1B1, ALOX15, AXL, BCL2, CNR1, CYP1B1, FABP4, FLT3, HTR2A, HTR2B, HTR2C, HTR6, IDO1, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 5.09932
[BP] GO:0032502 developmental process ACHE, AKR1B1, ALOX15, ALPL, AURKB, AXL, BCL2, CA2, CA9, CDC25B, CHRM2, CNR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, FUT7, HSD11B1, HSD17B2, HTR2A, HTR2B, HTR5A, KDR, MET, MMP2, MMP9, MPO, PIK3CA, PIK3CB, PIM1, PTGS2, RORC, SRC, TNKS2, TYR 5.04445
[BP] GO:0019369 arachidonic acid metabolic process ALOX15, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 5.02852
[BP] GO:0043069 negative regulation of programmed cell death AKR1B1, AURKB, AXL, BCL2, HTR2B, IDO1, IGF1R, KDR, MET, MMP9, MPO, PIK3CA, PIM1, PTGS2, PTPN1, SRC 5.01359
[BP] GO:0032496 response to lipopolysaccharide ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, IDO1, MPO, PTGS2, SRC 4.97708
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 4.92199
[BP] GO:0019216 regulation of lipid metabolic process CNR1, CYP1A1, FABP3, FLT3, HCAR2, HTR2A, HTR2B, HTR2C, PTGS2, RORC, SRC 4.92199
[BP] GO:0009725 response to hormone AKR1B1, ALPL, BCL2, CA2, CA9, CYP1A2, ESR1, FABP3, FLT3, HSD11B2, HTR1B, HTR5A, PTGS2, SRC 4.90115
[BP] GO:0003018 None HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2, SRC 4.78431
[BP] GO:0007188 None CHRM2, CNR1, HTR1A, HTR1B, HTR1D, HTR1E, HTR5A, HTR7 4.76783
[BP] GO:0014065 phosphatidylinositol 3-kinase signaling HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB 4.75679
[BP] GO:0002237 response to molecule of bacterial origin ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, IDO1, MPO, PTGS2, SRC 4.74906
[BP] GO:0006690 icosanoid metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 4.74822
[BP] GO:0099536 None CHRM2, CNR1, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 4.723
[BP] GO:0099537 None CHRM2, CNR1, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 4.723
[BP] GO:0032228 regulation of synaptic transmission, GABAergic CA2, CA7, CNR1, CNR2, HTR1B 4.70899
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, CNR1, HCAR2, PIK3CB, PTGS2, TNKS, TNKS2 4.70542
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALOX15, ALPL, AXL, BCL2, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, HTR1B, IGF1R, KDR, MMP2, MMP9, PIK3CA, PTGS2, RORC, SRC 4.70542
[BP] GO:0048518 positive regulation of biological process ACHE, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CNR1, CYP19A1, CYP1A1, CYP1B1, ESR1, FABP3, FABP4, FLT3, HCAR2, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IDO1, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, XDH 4.69602
[BP] GO:0050795 None CNR1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B 4.68725
[BP] GO:1902531 regulation of intracellular signal transduction AKR1B1, ALOX15, AURKB, AXL, BCL2, CYP1B1, ESR1, FLT3, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 4.6392
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALOX15, ALPL, AXL, BCL2, CYP1A1, CYP1B1, ESR1, FABP4, FLT3, HTR1B, IGF1R, KDR, MMP2, PIK3CA, PTGS2, RORC, SRC 4.61035
[BP] GO:0060548 negative regulation of cell death AKR1B1, AURKB, AXL, BCL2, HTR2B, IDO1, IGF1R, KDR, MET, MMP9, MPO, PIK3CA, PIM1, PTGS2, PTPN1, SRC 4.59025
[BP] GO:0007165 signal transduction ADORA3, AKR1B1, AXL, BCL2, CA1, CA2, CHRM2, CNR1, CNR2, CYP1B1, ESR1, FLT3, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PTPN1, RORC, SRC, TNKS, TNKS2 4.55786
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.46021
[BP] GO:0043066 negative regulation of apoptotic process AKR1B1, AURKB, AXL, BCL2, HTR2B, IDO1, IGF1R, KDR, MMP9, MPO, PIK3CA, PIM1, PTGS2, PTPN1, SRC 4.41674
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, SRC 4.41674
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, BCL2, CA2, CA9, CYP1A2, ESR1, FABP3, FLT3, HSD11B2, HTR1B, HTR5A, IGF1R, MMP2, PTGS2, SRC 4.41674
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, PTGS2, SRC 4.32401
[BP] GO:0071071 None FABP3, HTR2A, HTR2B, HTR2C 4.3156
[BP] GO:0097746 None HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 4.31231
[BP] GO:0035296 None HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 4.31231
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CDC25B, ESR1, FLT3, HTR1A, HTR1B, HTR2A, HTR2B, IGF1R, KDR, MMP2, MMP9, PIM1, PTGS2 4.24971
[BP] GO:0050880 None HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 4.13909
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX15, CYP19A1, CYP1A1, HSD11B1, HSD11B2, HSD17B2, PIK3CA, PIK3CB, PTGS1, PTGS2 4.12462
[BP] GO:0035150 None HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 4.12462
[BP] GO:0010513 None HTR2A, HTR2B, HTR2C 4.11643
[BP] GO:0003013 None HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2, SRC 3.99023
[BP] GO:0042592 homeostatic process AKR1B1, AXL, BCL2, CA12, CA2, CA7, CNR1, ESR1, FABP3, FABP4, FLT3, HTR2A, HTR2B, HTR2C, MET, PIK3CA, PIK3CB, SRC 3.96519
[BP] GO:2000021 regulation of ion homeostasis BCL2, CA2, CA7, HTR2A, HTR2B, HTR2C, KDR, SRC 3.95143
[BP] GO:0048878 chemical homeostasis AKR1B1, BCL2, CA12, CA2, CA7, CNR1, ESR1, FABP3, FABP4, HTR2A, HTR2B, HTR2C, MET, PIK3CA, PIK3CB 3.92665
[BP] GO:0001934 positive regulation of protein phosphorylation ALOX15, BCL2, CDC25B, FLT3, HTR2A, HTR2B, HTR2C, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 3.92061
[BP] GO:0032845 None BCL2, HTR2A, HTR2B, HTR2C, SRC, TNKS, TNKS2 3.92061
[BP] GO:0007268 None CHRM2, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 3.88907
[BP] GO:0098916 None CHRM2, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 3.88907
[BP] GO:0010562 positive regulation of phosphorus metabolic process ALOX15, BCL2, CDC25B, FABP3, FLT3, HTR2A, HTR2B, HTR2C, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 3.83728
[BP] GO:0045937 positive regulation of phosphate metabolic process ALOX15, BCL2, CDC25B, FABP3, FLT3, HTR2A, HTR2B, HTR2C, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 3.83728
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, MET, PIK3CA, PIK3CB, PTGS1, PTGS2 3.83728
[BP] GO:0048545 response to steroid hormone ALPL, BCL2, CA2, FLT3, HSD11B2, HTR1B, PTGS2, SRC 3.81687
[BP] GO:0019220 regulation of phosphate metabolic process ALOX15, BCL2, CDC25B, FABP3, FABP4, FLT3, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 3.752
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC 3.74329
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, FLT3, HSD11B2, HTR1B, PTGS2, SRC 3.74329
[BP] GO:1901568 fatty acid derivative metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 3.74329
[BP] GO:0042327 positive regulation of phosphorylation ALOX15, BCL2, CDC25B, FLT3, HTR2A, HTR2B, HTR2C, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 3.72521
[BP] GO:0051174 regulation of phosphorus metabolic process ALOX15, BCL2, CDC25B, FABP3, FABP4, FLT3, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 3.7206
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX15, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 3.68543
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1, MPO 3.67072
[BP] GO:0010511 None HTR2A, HTR2B, HTR2C 3.66133
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, ALPL, AURKB, AXL, BCL2, CDC25B, FLT3, HTR2B, HTR2C, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, TNKS, XDH 3.59145
[BP] GO:0008152 metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD11B2, HSD17B2, HTR1A, HTR1B, HTR2B, HTR2C, IDO1, IGF1R, KDR, MET, MMP1, MMP2, MMP9, MPO, NQO2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, TYR, XDH 3.53065
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B2 3.51732
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B2 3.48531
[BP] GO:0048015 phosphatidylinositol-mediated signaling HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB 3.48531
[BP] GO:0009991 response to extracellular stimulus ALPL, AXL, BCL2, CNR1, CYP1A1, HSD11B2, MPO, PTGS2, SRC, TYR 3.48178
[BP] GO:0008283 cell proliferation ACHE, AURKB, BCL2, CYP1A1, ESR1, FLT3, HTR1A, MET, PIK3CB, PIM1, SRC, TYR 3.47872
[BP] GO:0006979 response to oxidative stress AKR1B1, AXL, BCL2, CYP1B1, MMP9, MPO, PTGS1, PTGS2, SRC 3.40466
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, NQO2, PTGS1, RORC 3.40405
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, CNR2, HTR1B, HTR2A, PTGS2 3.40405
[BP] GO:0046889 None FABP3, HTR2A, HTR2B, HTR2C, PTGS2 3.40405
[BP] GO:0048017 inositol lipid-mediated signaling HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB 3.40405
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FLT3, FUT7, HSD17B2, HTR1A, HTR1B, HTR2B, HTR2C, IDO1, IGF1R, KDR, MET, MMP1, MMP2, MPO, NQO2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, TYR, XDH 3.36048
[BP] GO:0001932 regulation of protein phosphorylation ALOX15, BCL2, CDC25B, FABP4, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 3.33132
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, ALPL, AURKB, AXL, BCL2, CDC25B, FLT3, HTR2B, HTR2C, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, TNKS, XDH 3.3298
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALOX15, ALPL, AURKB, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, HTR1B, IGF1R, KDR, MMP2, MMP9, PIK3CA, PTGS2, PTPN1, RORC, SRC 3.26343
[BP] GO:0032879 regulation of localization ACHE, ADORA3, ALOX15, AXL, BCL2, CA2, CA7, CNR1, CYP19A1, CYP1B1, HCAR2, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, MMP9, PIK3CB, PTGS2, PTPN1, SRC 3.2603
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.19909
[BP] GO:0048010 vascular endothelial growth factor receptor signaling pathway AXL, KDR, PIK3CA, PIK3CB, SRC 3.17154
[BP] GO:0048583 regulation of response to stimulus AKR1B1, ALOX15, AURKB, AXL, BCL2, CNR1, CNR2, CYP19A1, CYP1B1, ESR1, FABP4, FLT3, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IDO1, IGF1R, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 3.10757
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, HTR1B, MMP2, MMP9, PTGS2 3.066
[BP] GO:0009628 response to abiotic stimulus AKR1B1, AURKB, BCL2, CA2, CYP1A1, HSD11B2, HTR1B, HTR2A, HTR2B, MMP2, MPO, PTGS2, SRC, TYR 3.02602
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA3, AKR1B1, AURKB, AXL, BCL2, CNR1, CNR2, CYP19A1, CYP1B1, ESR1, FABP3, FABP4, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IDO1, IGF1R, KDR, MET, MMP9, MPO, PIK3CA, PIM1, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, XDH 3.008
[BP] GO:0007154 None AXL, BCL2, CHRM2, CNR1, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, PTGS2 3.008
[BP] GO:0046456 icosanoid biosynthetic process ALOX15, ALOX5, PTGS1, PTGS2 2.99648
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA3, AKR1B1, ALOX15, AURKB, AXL, BCL2, CNR1, CNR2, CYP19A1, CYP1B1, ESR1, FABP3, FABP4, HCAR2, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IDO1, IGF1R, KDR, MET, MMP9, MPO, PIK3CA, PIM1, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, XDH 2.9892
[BP] GO:0006631 fatty acid metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, PTGS1, PTGS2 2.9892
[BP] GO:0044092 negative regulation of molecular function ADORA3, AURKB, CNR1, CNR2, CYP1B1, ESR1, FABP4, IGF1R, MET, MMP9, PIM1, PTGS2, PTPN1, SRC, TNKS 2.96812
[BP] GO:0006950 response to stress ACHE, ADORA3, AKR1B1, ALOX15, AXL, BCL2, CA2, CA9, CNR2, CYP1A1, CYP1A2, CYP1B1, HSD11B2, HTR1A, HTR2C, IDO1, MMP2, MMP9, MPO, PIK3CA, PIK3CB, PTGS1, PTGS2, PTPN1, SRC 2.953
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, CA2, CA7, CNR1, CNR2, HTR1B, HTR2A, PTGS2 2.94604
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, CA2, CA7, CNR1, CNR2, HTR1B, HTR2A, PTGS2 2.94604
[BP] GO:0043271 negative regulation of ion transport BCL2, CNR1, HTR1B, HTR2A, MMP9, PTGS2 2.9437
[BP] GO:2000106 regulation of leukocyte apoptotic process AURKB, AXL, HCAR2, IDO1, PIK3CB 2.93858
[BP] GO:0043410 positive regulation of MAPK cascade ALOX15, FLT3, HTR2A, HTR2B, HTR2C, KDR, PIK3CB, PTPN1, SRC, XDH 2.92829
[BP] GO:0031667 response to nutrient levels ALPL, BCL2, CNR1, CYP1A1, HSD11B2, MPO, PTGS2, SRC, TYR 2.90495
[BP] GO:0010243 response to organonitrogen compound AKR1B1, CNR1, CNR2, FABP3, FLT3, HSD11B2, HTR1B, IGF1R, MMP2, PTGS2, SRC, TYR 2.90342
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CYP19A1, CYP1A1, CYP1A2, ESR1, FLT3, HSD11B1, HSD17B2, KDR, PIK3CA, SRC, TYR 2.90342
[BP] GO:0042325 regulation of phosphorylation ALOX15, BCL2, CDC25B, FABP4, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 2.90342
[BP] GO:0051049 regulation of transport ACHE, ALOX15, AXL, BCL2, CA2, CA7, CNR1, CYP19A1, HCAR2, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, MMP9, PIK3CB, PTGS2, PTPN1, SRC 2.86927
[BP] GO:0007208 None HTR2A, HTR2C 2.86927
[BP] GO:0022414 reproductive process AKR1B1, ALPL, AXL, BCL2, CDC25B, CNR1, CYP19A1, CYP1A1, ESR1, HSD11B2, HSD17B2, IDO1, MMP2, MMP9, PTGS2, SRC 2.8611
[BP] GO:0071248 cellular response to metal ion ALOX15, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 2.85419
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALOX15, BCL2, CYP19A1, CYP1A1, CYP1B1, HTR1A, TYR 2.85419
[BP] GO:0007200 None CHRM2, ESR1, HTR2A, HTR2B, HTR2C 2.84505
[BP] GO:0031401 positive regulation of protein modification process ALOX15, BCL2, CDC25B, FLT3, HTR2A, HTR2B, HTR2C, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 2.83194
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.80707
[BP] GO:0010038 response to metal ion ALOX15, BCL2, CA2, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 2.80707
[BP] GO:0007568 aging AURKB, BCL2, CNR1, CYP1A1, HTR2A, MPO, PTGS2 2.78413
[BP] GO:0003008 None AKR1B1, BCL2, CNR1, CNR2, CYP1B1, HSD11B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PIK3CA, PTGS2, SRC, TYR 2.76275
[BP] GO:0006468 protein phosphorylation AURKB, AXL, BCL2, CDC25B, FLT3, HTR2B, IGF1R, KDR, MET, PIK3CA, PIM1, SRC, TNKS 2.73218
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC 2.69463
[BP] GO:0043207 response to external biotic stimulus ALPL, AXL, BCL2, CHRM2, CNR1, CNR2, CYP1A1, CYP1A2, IDO1, MPO, PTGS2, SRC 2.6849
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, MMP9, PTGS2, PTPN1, SRC 2.6849
[BP] GO:0044283 None AKR1B1, ALOX15, ALOX5, CYP19A1, CYP1A1, IDO1, MPO, PTGS1, PTGS2 2.6827
[BP] GO:0065007 biological regulation ACHE, ADORA3, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA1, CA12, CA2, CA7, CA9, CDC25B, CHRM2, CNR1, CNR2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FLT3, HCAR2, HSD11B1, HSD11B2, HSD17B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IDO1, IGF1R, KDR, MET, MMP1, MMP2, MMP9, MPO, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, XDH 2.6815
[BP] GO:0022900 electron transport chain AKR1B1, CYP19A1, CYP1A2, IDO1, NQO2, XDH 2.66741
[BP] GO:2000811 negative regulation of anoikis BCL2, PIK3CA, SRC 2.65542
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.65542
[BP] GO:0019372 lipoxygenase pathway ALOX15, ALOX5, PTGS2 2.65542
[BP] GO:1901698 response to nitrogen compound AKR1B1, CNR1, CNR2, FABP3, FLT3, HSD11B2, HTR1B, IGF1R, MMP2, PTGS2, SRC, TYR 2.63407
[BP] GO:0006939 None HTR1D, HTR2A, HTR2B, HTR7 2.63407
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.57826
[BP] GO:0016477 cell migration AXL, CNR2, CYP1B1, FUT7, HTR2B, HTR6, KDR, MMP1, MMP9, PIK3CA, PIK3CB, SRC 2.56733
[BP] GO:0072593 reactive oxygen species metabolic process BCL2, CYP1A1, CYP1A2, CYP1B1, MPO 2.55788
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, CYP1A1, CYP1B1, ESR1, FLT3, PTGS2, RORC, SRC 2.5531
[BP] GO:0071241 cellular response to inorganic substance ALOX15, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 2.54089
[BP] GO:0009607 response to biotic stimulus ALPL, AXL, BCL2, CHRM2, CNR1, CNR2, CYP1A1, CYP1A2, IDO1, MPO, PTGS2, SRC 2.53473
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, BCL2, CYP1B1, MMP9, SRC 2.5166
[BP] GO:0043408 regulation of MAPK cascade ALOX15, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, PIK3CB, PTPN1, SRC, XDH 2.48124
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.48002
[BP] GO:0016310 phosphorylation AURKB, AXL, BCL2, CDC25B, FLT3, HTR2B, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, SRC, TNKS 2.47622
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.47002
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, BCL2, CYP1B1, SRC 2.46156
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, SRC 2.46156
[BP] GO:0033555 multicellular organismal response to stress BCL2, HTR1A, HTR2C, IDO1 2.46109
[BP] GO:0009056 catabolic process ACHE, AKR1B10, AURKB, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, IDO1, MMP1, MMP2, MMP9, MPO, PIK3CB, SRC, XDH 2.4595
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.4595
[BP] GO:0032787 None ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, IDO1, PTGS1, PTGS2 2.43922
[BP] GO:0090066 None ALOX15, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 2.43143
[BP] GO:0051130 positive regulation of cellular component organization ALOX15, AURKB, AXL, BCL2, CNR1, ESR1, IGF1R, KDR, MET, MMP1, MMP9, SRC, TNKS, TNKS2 2.42115
[BP] GO:0043065 positive regulation of apoptotic process BCL2, CNR1, CYP1B1, HCAR2, IDO1, MMP9, PIK3CB, PTGS2, SRC, XDH 2.39892
[BP] GO:0040011 locomotion AXL, CNR2, CYP1B1, FUT7, HTR2B, HTR6, KDR, MET, MMP1, MMP9, PIK3CA, PIK3CB, SRC 2.39892
[BP] GO:0048856 anatomical structure development ACHE, AKR1B1, ALOX15, ALPL, AXL, BCL2, CA2, CHRM2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FLT3, HSD11B1, HSD17B2, HTR5A, KDR, MMP9, PIK3CA, PIM1, PTGS2, RORC, SRC, TYR 2.39716
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ALOX15, HTR2A, HTR2B, HTR2C, KDR, PTPN1, SRC 2.39191
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, SRC 2.39191
[BP] GO:0001503 ossification ALOX15, ALPL, BCL2, MMP2, MMP9 2.37332
[BP] GO:0043068 positive regulation of programmed cell death BCL2, CNR1, CYP1B1, HCAR2, IDO1, MMP9, PIK3CB, PTGS2, SRC, XDH 2.37332
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, SRC 2.35852
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.35123
[BP] GO:0032094 None CYP1A1, HSD11B2, MPO 2.35123
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.35123
[BP] GO:0034502 protein localization to chromosome AURKB, ESR1, TNKS, TNKS2 2.34298
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic CNR1, HTR1B, HTR2A, PTGS2 2.34298
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, AXL, CYP1B1, ESR1, IGF1R, MMP2, MMP9, PIK3CA, PTGS2, RORC, SRC 2.34003
[BP] GO:0032270 positive regulation of cellular protein metabolic process ALOX15, BCL2, CDC25B, ESR1, FLT3, HTR2A, HTR2B, HTR2C, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 2.33369
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, HTR1B, KDR, PTGS2, SRC 2.33279
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.32104
[BP] GO:0007267 None CHRM2, CNR1, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 2.31619
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation HTR1B, MMP2, MMP9 2.30412
[BP] GO:0046777 protein autophosphorylation AURKB, FLT3, IGF1R, KDR, PIM1, SRC 2.29317
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade ALOX15, HTR2A, HTR2B, HTR2C, KDR, SRC 2.28259
[BP] GO:2000209 regulation of anoikis BCL2, PIK3CA, SRC 2.2512
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.2512
[BP] GO:0048870 cell motility AXL, CNR2, CYP1B1, FUT7, HTR2B, HTR6, KDR, MMP1, MMP9, PIK3CA, PIK3CB, SRC 2.25067
[BP] GO:0050790 regulation of catalytic activity ADORA3, AURKB, BCL2, CDC25B, CNR1, CNR2, ESR1, FABP4, FLT3, HTR2A, HTR2B, IGF1R, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TNKS, XDH 2.24835
[BP] GO:0009966 regulation of signal transduction AKR1B1, ALOX15, AURKB, AXL, BCL2, CYP1B1, ESR1, FLT3, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 2.24584
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, ESR1, IGF1R, MET, MMP9, PTGS2, PTPN1, SRC, XDH 2.2434
[BP] GO:0033031 positive regulation of neutrophil apoptotic process HCAR2, PIK3CB 2.2434
[BP] GO:0070213 None TNKS, TNKS2 2.2434
[BP] GO:0038171 None CNR1, CNR2 2.2434
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.2434
[BP] GO:0014827 None HTR1D, HTR2B 2.2434
[BP] GO:2000573 positive regulation of DNA biosynthetic process AURKB, SRC, TNKS, TNKS2 2.23876
[BP] GO:0009605 response to external stimulus ALPL, AXL, BCL2, CHRM2, CNR1, CNR2, CYP1A1, CYP1A2, HSD11B2, HTR2A, IDO1, MPO, PTGS2, SRC, TYR 2.23265
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PTGS2, SRC 2.23265
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B2 2.21781
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B2 2.21698
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, HTR1B, MMP2, MMP9, PTGS2 2.18853
[BP] GO:0031399 regulation of protein modification process ALOX15, BCL2, CDC25B, FABP4, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 2.17315
[BP] GO:0010942 positive regulation of cell death BCL2, CNR1, CYP1B1, HCAR2, IDO1, MMP9, PIK3CB, PTGS2, SRC, XDH 2.15753
[BP] GO:0051896 regulation of protein kinase B signaling AXL, MET, PIK3CA, PIK3CB, SRC, XDH 2.1502
[BP] GO:0043436 oxoacid metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, IDO1, MPO, PIM1, PTGS1, PTGS2, TYR 2.14221
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3 2.12818
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, IDO1 2.12796
[BP] GO:1904353 regulation of telomere capping AURKB, TNKS, TNKS2 2.12375
[BP] GO:0050801 ion homeostasis BCL2, CA12, CA2, CA7, ESR1, FABP3, HTR2A, HTR2B, HTR2C, PIK3CB 2.12375
[BP] GO:0007610 None BCL2, CNR1, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, IDO1, PTGS2 2.12304
[BP] GO:0050794 regulation of cellular process ACHE, ADORA3, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA1, CA2, CA7, CA9, CDC25B, CHRM2, CNR1, CNR2, CYP19A1, CYP1A1, CYP1B1, ESR1, FABP3, FABP4, FLT3, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IDO1, IGF1R, KDR, MET, MMP1, MMP2, MMP9, MPO, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, XDH 2.11025
[BP] GO:0051247 positive regulation of protein metabolic process ALOX15, BCL2, CDC25B, ESR1, FLT3, HTR2A, HTR2B, HTR2C, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 2.102
[BP] GO:0010507 negative regulation of autophagy BCL2, HTR2B, MET, PIK3CA 2.08862
[BP] GO:0006082 organic acid metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, IDO1, MPO, PIM1, PTGS1, PTGS2, TYR 2.08486
[BP] GO:1904357 None SRC, TNKS, TNKS2 2.08486
[BP] GO:1903530 regulation of secretion by cell ACHE, CNR1, CYP19A1, HCAR2, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, SRC 2.06718
[BP] GO:0071502 None HTR1B, HTR2B 2.05803
[BP] GO:0006952 defense response ADORA3, ALOX15, AXL, BCL2, CNR2, HTR1A, HTR2C, MPO, PIK3CA, PIK3CB, PTGS1, PTGS2, SRC 2.05601
[BP] GO:0051347 positive regulation of transferase activity AURKB, CDC25B, FLT3, HTR2A, HTR2B, PIK3CA, PIK3CB, PTPN1, SRC, TNKS 2.05601
[BP] GO:0051384 response to glucocorticoid ALPL, BCL2, FLT3, HSD11B2, PTGS2 2.04989
[BP] GO:2000108 None HCAR2, IDO1, PIK3CB 2.0485
[BP] GO:0033032 regulation of myeloid cell apoptotic process BCL2, HCAR2, PIK3CB 2.0485
[BP] GO:0014059 None CNR1, HTR1B, HTR2A 2.0485
[BP] GO:0001101 response to acid chemical AKR1B1, FABP3, HSD17B2, KDR, MMP2, PTGS2, SRC 2.04674
[BP] GO:0006954 inflammatory response ADORA3, ALOX15, AXL, CNR2, PIK3CA, PIK3CB, PTGS1, PTGS2 2.03854
[BP] GO:0006636 unsaturated fatty acid biosynthetic process ALOX15, PTGS1, PTGS2 2.00935
[BP] GO:0033280 response to vitamin D ALPL, PTGS2, TYR 2.00935
[BP] GO:0023052 None CHRM2, CNR1, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 2.00465
[CC] GO:0044425 membrane part ACHE, ADORA3, ALOX15, ALPL, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM2, CNR1, CNR2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FLT3, FUT7, HCAR2, HSD11B1, HSD11B2, HSD17B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, MPEG1, PIK3CA, PIK3CB, PTGS1, PTGS2, PTPN1, SRC, TYR 5.88884
[CC] GO:0016020 membrane ACHE, ADORA3, ALOX15, ALOX5, ALPL, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM2, CNR1, CNR2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FLT3, FUT7, HCAR2, HSD11B1, HSD11B2, HSD17B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, MMP2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SRC, TNKS, TNKS2, TYR 5.82325
[CC] GO:0031226 intrinsic component of plasma membrane ADORA3, AXL, CA4, CHRM2, CNR1, CNR2, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET 5.38652
[CC] GO:0005887 integral component of plasma membrane ADORA3, AXL, CHRM2, CNR1, CNR2, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET 5.01359
[CC] GO:0005886 plasma membrane ACHE, ADORA3, ALOX15, ALPL, AXL, CA12, CA14, CA2, CA4, CA9, CHRM2, CNR1, CNR2, ESR1, FLT3, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, MMP2, PIK3CA, PIK3CB, PIM1, PTPN1, SRC 4.98189
[CC] GO:0044459 plasma membrane part ADORA3, ALOX15, AXL, CA2, CA4, CA9, CHRM2, CNR1, CNR2, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, PTGS2, SRC 4.15502
[CC] GO:0031224 None ACHE, ADORA3, ALPL, AXL, CA12, CA14, CA4, CA9, CHRM2, CNR1, CNR2, ESR1, FLT3, FUT7, HCAR2, HSD11B1, HSD17B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, MPEG1, TYR 2.00465
[MF] GO:0004993 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 17.3156
[MF] GO:0099589 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 17.3156
[MF] GO:0043176 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 17.0838
[MF] GO:0051378 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 17.0838
[MF] GO:0099528 None CHRM2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 17.0756
[MF] GO:0008227 None CHRM2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 14.7383
[MF] GO:0042165 neurotransmitter binding ACHE, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 11.4158
[MF] GO:0030594 None CHRM2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 11.2898
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 10.3683
[MF] GO:0070405 ammonium ion binding ACHE, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 10.0504
[MF] GO:0043167 ion binding ACHE, ALOX15, ALOX5, ALPL, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, IDO1, IGF1R, KDR, MET, MMP1, MMP2, MMP9, MPO, NQO2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, TYR, XDH 9.86399
[MF] GO:0046914 transition metal ion binding ALOX15, ALOX5, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, MMP1, MMP2, MMP9, NQO2, PIM1, PTPN1, RORC, TNKS, TYR, XDH 9.22491
[MF] GO:0043169 cation binding ACHE, ALOX15, ALOX5, ALPL, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, IDO1, MMP1, MMP2, MMP9, MPO, NQO2, PIM1, PTGS1, PTGS2, PTPN1, RORC, TNKS, TNKS2, TYR, XDH 8.38408
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B1, HSD11B2, HSD17B2, IDO1, MPO, NQO2, PTGS1, PTGS2, TYR, XDH 7.52184
[MF] GO:0038023 signaling receptor activity ADORA3, AXL, CHRM2, CNR1, CNR2, ESR1, FLT3, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, RORC 7.18246
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, IDO1, MPO, PTGS1, PTGS2, SRC 6.4599
[MF] GO:0099600 transmembrane receptor activity ADORA3, AXL, CHRM2, CNR1, CNR2, FLT3, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET 6.40772
[MF] GO:0004888 transmembrane signaling receptor activity ADORA3, AXL, CHRM2, CNR1, CNR2, FLT3, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET 6.40772
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.38342
[MF] GO:0004872 receptor activity ADORA3, AXL, CHRM2, CNR1, CNR2, ESR1, FLT3, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, RORC 6.32108
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, IDO1, MPO, PTGS1, PTGS2, SRC 6.26533
[MF] GO:0003824 catalytic activity ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FLT3, FUT7, HSD11B1, HSD11B2, HSD17B2, IDO1, IGF1R, KDR, MET, MMP1, MMP2, MMP9, MPO, NQO2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SRC, TNKS, TNKS2, TYR, XDH 6.1707
[MF] GO:0060089 molecular transducer activity ADORA3, AXL, CHRM2, CNR1, CNR2, ESR1, FLT3, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, RORC 6.10057
[MF] GO:0004871 signal transducer activity ADORA3, AXL, CHRM2, CNR1, CNR2, ESR1, FLT3, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, RORC 5.62748
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 5.58923
[MF] GO:0004930 None ADORA3, CHRM2, CNR1, CNR2, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 5.01076
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CHRM2, CNR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FLT3, HTR1B, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, NQO2, PIK3CA, PIK3CB, PIM1, SRC 4.96033
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B2, IDO1, MPO, NQO2, PTGS1, PTGS2, SRC, XDH 4.68649
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, ESR1, MMP1, MMP2, MMP9, NQO2, PTPN1, RORC, TNKS 3.95143
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, TYR 3.74329
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.7358
[MF] GO:0005506 iron ion binding ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, XDH 3.67025
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.54039
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX15, ALOX5, IDO1, PTGS2 3.54039
[MF] GO:0009055 electron transfer activity AKR1B1, CYP19A1, CYP1A2, IDO1, NQO2, XDH 3.51732
[MF] GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen ALOX15, ALOX5, IDO1, PTGS2 3.48531
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.45873
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 3.3298
[MF] GO:0043560 insulin receptor substrate binding IGF1R, PIK3CA, PIK3CB 3.06984
[MF] GO:0046872 metal ion binding ALOX15, ALOX5, ALPL, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, IDO1, MMP1, MMP2, MMP9, MPO, NQO2, PIM1, PTGS1, PTGS2, PTPN1, RORC, TNKS, TNKS2, TYR, XDH 3.06719
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, HSD11B1, HSD11B2, HSD17B2, XDH 3.008
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 2.99648
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 2.86927
[MF] GO:0003845 None HSD11B1, HSD11B2 2.86927
[MF] GO:0071886 None HTR2A, HTR2C 2.86927
[MF] GO:0051213 dioxygenase activity ALOX15, ALOX5, IDO1, PTGS1, PTGS2 2.78413
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 2.72166
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, TYR 2.6849
[MF] GO:0050473 arachidonate 15-lipoxygenase activity ALOX15, PTGS2 2.47002
[MF] GO:0004949 None CNR1, CNR2 2.47002
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, SRC 2.44343
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, HSD11B1, HSD11B2, HSD17B2 2.30638
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD11B2, HSD17B2 2.08486
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD11B2, HSD17B2 2.00935


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Serotonergic synapse_Homo sapiens_hsa04726 HTR1E, ALOX15, HTR1D, HTR2B, HTR1A, HTR1B, HTR2C, HTR2A, PTGS2, HTR5A, HTR4, PTGS1, HTR6, HTR7, ALOX5 17.6128
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, HTR1E, HTR1D, HTR2B, HTR1A, HTR1B, HTR2C, HTR2A, HTR5A, HTR4, HTR6, HTR7, CNR2, CNR1, ADORA3 11.9329
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 7.9642
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 11.5123
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, HCAR2, HTR6, PIK3CA, HTR1E, HTR1D, HTR1A, HTR1B, PIK3CB, HTR4 7.5656
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 7.5918
Proteoglycans in cancer_Homo sapiens_hsa05205 PIK3CA, SRC, MMP2, KDR, PIK3CB, MMP9, MET, ESR1, IGF1R 6.3016
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, HTR6, HTR7, HTR2B, HTR2C, HTR2A, HTR5A, HTR4 5.5667
Pathways in cancer_Homo sapiens_hsa05200 PIK3CA, FLT3, MMP1, MMP2, BCL2, PIK3CB, PTGS2, MMP9, MET, IGF1R 4.9169
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 PIK3CA, SRC, HTR2B, HTR2C, PIK3CB, HTR2A 4.8948
Estrogen signaling pathway_Homo sapiens_hsa04915 PIK3CA, SRC, MMP2, PIK3CB, MMP9, ESR1 4.8948
Metabolic pathways_Homo sapiens_hsa01100 ALOX15, AKR1B1, PTGS2, TYR, CYP19A1, PTGS1, HSD11B1, FUT7, AKR1B10, ALOX5, HSD17B2, CYP1A2, CYP1A1, ALPL, XDH, IDO1 4.6176
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PIK3CA, PIK3CB, PTGS2, PTGS1 4.8428
VEGF signaling pathway_Homo sapiens_hsa04370 PIK3CA, SRC, KDR, PIK3CB, PTGS2 4.691
Focal adhesion_Homo sapiens_hsa04510 PIK3CA, SRC, KDR, BCL2, PIK3CB, MET, IGF1R 4.3221
Rap1 signaling pathway_Homo sapiens_hsa04015 PIK3CA, SRC, CNR1, KDR, PIK3CB, MET, IGF1R 4.2523
MicroRNAs in cancer_Homo sapiens_hsa05206 PIK3CA, BCL2, PIM1, CYP1B1, PTGS2, MMP9, MET, CDC25B 4.2523
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 PIK3CA, MMP2, BCL2, PIM1, PIK3CB 3.8199
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, PIK3CA, BCL2, PIK3CB 3.6421
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP1A2, CYP1A1, CYP1B1, PTGS2 4.1944
Acute myeloid leukemia_Homo sapiens_hsa05221 PIK3CA, FLT3, PIM1, PIK3CB 3.6101
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1, IDO1 4.1442
Ras signaling pathway_Homo sapiens_hsa04014 HTR7, PIK3CA, KDR, PIK3CB, MET, IGF1R 3.2895
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 4.123
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, PIK3CA, KDR, BCL2, PIK3CB, MET, IGF1R 3.2256
Melanoma_Homo sapiens_hsa05218 PIK3CA, PIK3CB, MET, IGF1R 3.2895
Hepatitis B_Homo sapiens_hsa05161 PIK3CA, SRC, BCL2, PIK3CB, MMP9 3.2393
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, ALOX15, PTGS2, PTGS1 3.4841
Prolactin signaling pathway_Homo sapiens_hsa04917 PIK3CA, SRC, PIK3CB, ESR1 3.2895
Central carbon metabolism in cancer_Homo sapiens_hsa05230 PIK3CA, FLT3, PIK3CB, MET 3.3694
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP1A2, CYP1A1, CYP1B1 3.2895
Adherens junction_Homo sapiens_hsa04520 PTPN1, SRC, MET, IGF1R 3.2895
Taste transduction_Homo sapiens_hsa04742 HTR1E, HTR1D, HTR1A, HTR1B 3.1532
Prostate cancer_Homo sapiens_hsa05215 PIK3CA, BCL2, PIK3CB, IGF1R 3.072
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 PIK3CA, SRC, PIK3CB, MET 3.2322
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PIK3CA, PIK3CB, CDC25B, IGF1R 2.934
Small cell lung cancer_Homo sapiens_hsa05222 PIK3CA, BCL2, PIK3CB, PTGS2 3.1059
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, MPO, IGF1R 2.9245
Gap junction_Homo sapiens_hsa04540 SRC, HTR2B, HTR2C, HTR2A 3.0793
TNF signaling pathway_Homo sapiens_hsa04668 PIK3CA, PIK3CB, PTGS2, MMP9 2.7747
HIF-1 signaling pathway_Homo sapiens_hsa04066 PIK3CA, BCL2, PIK3CB, IGF1R 2.8729
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 PIK3CA, SRC, PIK3CB, ESR1 2.6893
Toxoplasmosis_Homo sapiens_hsa05145 PIK3CA, ALOX5, BCL2, PIK3CB 2.6893
Platelet activation_Homo sapiens_hsa04611 PIK3CA, SRC, PIK3CB, PTGS1 2.6535
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PIK3CA, MMP2, PIK3CB, MMP9 2.6893
Sphingolipid signaling pathway_Homo sapiens_hsa04071 PIK3CA, ADORA3, BCL2, PIK3CB 2.6712
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIK3CA, BCL2, PIM1, PIK3CB 2.2975
Oxytocin signaling pathway_Homo sapiens_hsa04921 PIK3CA, SRC, PIK3CB, PTGS2 2.2975
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, PIK3CA, SRC, PIK3CB 1.8794
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 PIK3CA, PIK3CB, IGF1R 2.0228
ErbB signaling pathway_Homo sapiens_hsa04012 PIK3CA, SRC, PIK3CB 2.11
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.6428
Glioma_Homo sapiens_hsa05214 PIK3CA, PIK3CB, IGF1R 2.424
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PIK3CA, PIK3CB 1.8794
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 PIK3CA, PIK3CB, IGF1R 2.4349
Neurotrophin signaling pathway_Homo sapiens_hsa04722 PIK3CA, BCL2, PIK3CB 1.7778
Colorectal cancer_Homo sapiens_hsa05210 PIK3CA, BCL2, PIK3CB 2.4661
AMPK signaling pathway_Homo sapiens_hsa04152 PIK3CA, PIK3CB, IGF1R 1.7455
Renal cell carcinoma_Homo sapiens_hsa05211 PIK3CA, PIK3CB, MET 2.4132
Apoptosis_Homo sapiens_hsa04210 PIK3CA, BCL2, PIK3CB 1.6404
FoxO signaling pathway_Homo sapiens_hsa04068 PIK3CA, PIK3CB, IGF1R 1.6757
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, PIK3CA, PIK3CB 1.6428
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 PIK3CA, PIK3CB, IGF1R 1.6299
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 PIK3CA, BCL2, PIK3CB 1.5935
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1 2.3658
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 PIK3CA, ADORA3, PIK3CB 1.477
Epstein-Barr virus infection_Homo sapiens_hsa05169 PIK3CA, BCL2, PIK3CB 1.3103
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.2386
Viral carcinogenesis_Homo sapiens_hsa05203 PIK3CA, SRC, PIK3CB 1.299
Chemokine signaling pathway_Homo sapiens_hsa04062 PIK3CA, SRC, PIK3CB 1.3904
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2, PIK3CA, PIK3CB 2.9598
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3462
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.3562
Phagosome_Homo sapiens_hsa04145 MPO 0.3835
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 1.0787
Tight junction_Homo sapiens_hsa04530 SRC 0.415
HTLV-I infection_Homo sapiens_hsa05166 PIK3CA, PIK3CB 0.614
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4482
Cell cycle_Homo sapiens_hsa04110 CDC25B 0.4482
Axon guidance_Homo sapiens_hsa04360 MET 0.443
Osteoclast differentiation_Homo sapiens_hsa04380 PIK3CA, PIK3CB 0.9965
Measles_Homo sapiens_hsa05162 PIK3CA, PIK3CB 0.9867
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PIK3CA, PIK3CB 0.9255
Phospholipase D signaling pathway_Homo sapiens_hsa04072 PIK3CA, PIK3CB 0.9523
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 PIK3CA, PIK3CB 0.988
Hepatitis C_Homo sapiens_hsa05160 PIK3CA, PIK3CB 0.9952
Influenza A_Homo sapiens_hsa05164 PIK3CA, PIK3CB 0.838
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.8297
Choline metabolism in cancer_Homo sapiens_hsa05231 PIK3CA, PIK3CB 1.1753
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 1.2291
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PIK3CA, PIK3CB 1.2215
Melanogenesis_Homo sapiens_hsa04916 TYR 0.519
Amoebiasis_Homo sapiens_hsa05146 PIK3CA, PIK3CB 1.1753
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 PIK3CA, PIK3CB 1.1555
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PIK3CA, PIK3CB 1.1851
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5314
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 PIK3CA, PIK3CB 1.1658
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5308
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 CNR1, PTGS2 1.1753
T cell receptor signaling pathway_Homo sapiens_hsa04660 PIK3CA, PIK3CB 1.1658
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.5481
NF-kappa B signaling pathway_Homo sapiens_hsa04064 BCL2, PTGS2 1.2215
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5532
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5532
Peroxisome_Homo sapiens_hsa04146 XDH 0.5683
B cell receptor signaling pathway_Homo sapiens_hsa04662 PIK3CA, PIK3CB 1.3904
Chronic myeloid leukemia_Homo sapiens_hsa05220 PIK3CA, PIK3CB 1.3904
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 PIK3CA, PIK3CB 1.4274
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.6105
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.6085
Inositol phosphate metabolism_Homo sapiens_hsa00562 PIK3CA, PIK3CB 1.3976
Pancreatic cancer_Homo sapiens_hsa05212 PIK3CA, PIK3CB 1.4411
Bile secretion_Homo sapiens_hsa04976 CA2 0.6142
mTOR signaling pathway_Homo sapiens_hsa04150 PIK3CA, PIK3CB 1.5025
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2 0.6216
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.4274
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1 1.4481
Shigellosis_Homo sapiens_hsa05131 SRC 0.6413
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.6413
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.6653
Non-small cell lung cancer_Homo sapiens_hsa05223 PIK3CA, PIK3CB 1.5479
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.5107
Endometrial cancer_Homo sapiens_hsa05213 PIK3CA, PIK3CB 1.5976
Type II diabetes mellitus_Homo sapiens_hsa04930 PIK3CA, PIK3CB 1.6428
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 PIK3CA, PIK3CB 1.6757
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.7261
Malaria_Homo sapiens_hsa05144 MET 0.7383
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.7513
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.7562
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.9702
African trypanosomiasis_Homo sapiens_hsa05143 IDO1 0.8557
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.9223
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2 1.9918
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.8428
Tyrosine metabolism_Homo sapiens_hsa00350 TYR 0.8557
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8979
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.9523
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.9076
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.169
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.9431
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.1726
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.2895


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)