Prescription Description
| Prescription ID | TCMFx4569 |
| Pinyin Name | Kuan Xiong Shu Qi Hua Zhi Wan |
| Chinese Name | 宽胸舒气化滞丸 |
| English Name | Kuan Xiong Shu Qi Hua Zhi Pills |
| Function Description | 积滞, 胃脘痛, 症积, 便秘 |
| Indications | Stomach ache disorder, Constipation disorder, Dyspepsia, Enteritis |
| Disease ICD-11 Category |
SA51 [Stomach ache disorder (TM1), 胃脘痛 (TM1)
]; SA57 [Constipation disorder (TM1), 便秘 (TM1) ]; MD92 [Dyspepsia, 消化ä¸è‰¯ ]; 1A40.Z [Infectious gastroenteritis or colitis without specification of infectious agent, æœªç‰¹æŒ‡æ„ŸæŸ“æ€§ç—…åŽŸä½“çš„æ„ŸæŸ“æ€§èƒƒè‚ ç‚Žæˆ–ç»“è‚ ç‚Ž ]; |
| Human Tissues Associated with Indication | Stomach, Large Intestine |
| Reference | CFDA |
| Reference Book/link | http://samr.cfda.gov.cn/WS01/CL0001/ |
Prescription Components
| Component ID | Latin Name | Chinese Name | Component Quantity | Barcode |
|---|---|---|---|---|
| TCMH249 | Aquilaria agallocha | 沉香 | TCMH249 | KU879012 |
| TCMH1533 | Saussurea lappa | 木香 | TCMH1533 | |
| TCMH1695 | Pericarpium citri reticulatae viride | é’çš® | TCMH1695 | |
| TCMH243 | Pericarpium citri reticulatae | 陈皮 | TCMH243 | |
| TCMH1662 | Pharbitis nil | 牵牛å | TCMH1662 |
Targeted Human Proteins by the Ingredients of Prescription
| Target ID | Gene Symbol | Target Name | Target Class | Uniprot ID |
|---|---|---|---|---|
| TCMT127 | PARP1 | Poly [ADP-ribose] polymerase-1 | Transferase | P09874 |
| TCMT128 | TNKS2 | Tankyrase-2 | Transferase | Q9H2K2 |
| TCMT129 | TNKS | Tankyrase-1 | Transferase | O95271 |
| TCMT130 | ALOX5 | Arachidonate 5-lipoxygenase | Oxidoreductase | P09917 |
| TCMT156 | CYP19A1 | Cytochrome P450 19A1 | Oxidoreductase | P11511 |
| TCMT33 | CYP3A4 | Cytochrome P450 3A4 | Oxidoreductase | P08684 |
| TCMT599 | UBE2N | Ubiquitin-conjugating enzyme E2 N | Transferase | P61088 |
| TCMT678 | XIAP | Inhibitor of apoptosis protein 3 | Transferase | P98170 |
| TCMT679 | MPEG1 | Macrophage-expressed gene 1 protein | Unclassified | Q2M385 |
| TCMT680 | KAT2B | Histone acetyltransferase PCAF | Transferase | Q92831 |
Targeted Pathogenic Microbes by the Ingredients of Prescription
| Target ID | Target Name |
|---|---|
| TCMT1178 | Actinomyces viscosus |
| TCMT1209 | Staphylococcus haemolyticus |
| TCMT1210 | Streptococcus sobrinus |
| TCMT1211 | Fusobacterium nucleatum |
| TCMT1214 | Enterococcus faecium |
| TCMT1218 | Staphylococcus aureus |
| TCMT1219 | Enterococcus |
| TCMT1221 | Human herpesvirus 4 |
| TCMT1223 | Staphylococcus epidermidis |
| TCMT1226 | Klebsiella pneumoniae |
| TCMT1229 | Enterococcus faecalis |
| TCMT1246 | Escherichia coli |
| TCMT1251 | Candida albicans |
| TCMT1253 | Penicillium chrysogenum |
| TCMT1255 | Human immunodeficiency virus 1 |
| TCMT1292 | Japanese encephalitis virus |
| TCMT1297 | Punta Toro virus |
| TCMT1310 | Enterococcus hirae |
| TCMT1318 | Human T-lymphotropic virus 1 |
| TCMT1321 | Staphylococcus hominis |
| TCMT1336 | Yellow fever virus |
| TCMT1337 | Dengue virus type 4 |
| TCMT1338 | Rift Valley fever virus |
| TCMT1343 | Staphylococcus simulans |
| TCMT1344 | Staphylococcus sciuri |
| TCMT1355 | Rhodococcus equi |
| TCMT1370 | Prevotella melaninogenica |
| TCMT1438 | Plasmodium falciparum |
| TCMT1439 | Mycobacterium smegmatis |
| TCMT1444 | Fusarium oxysporum |
| TCMT1448 | Enterobacter aerogenes |
| TCMT1454 | Bacillus subtilis |
| TCMT1455 | Mycobacterium tuberculosis H37Rv |
| TCMT1458 | Filobasidiella neoformans |
| TCMT1462 | Streptococcus mutans |
| TCMT1463 | Mycobacterium tuberculosis |
Gene Ontology Associated to Targeted Human Proteins
| GO Term | GO Name | Enriched Genes | Log10 Adjusted P-value |
|---|
KEGG Pathways Associated to Targeted Human Proteins
| KEGG Pathway ID | Enriched Genes | Log10 Adjusted P-value |
|---|
Target Exprsssion in Healthy Human Tissues (protein & mRNA level)
Protein expression data was from the "Human Proteome Map" datasetmRNA expression data was from the "GTEx" dataset
Average Target Expression (Fold Change) in Multiple Disease Conditions
Fold Change with Corresponding Normal SamplesClick each cell within the heatmap to access gene expression of individual patient samples