TCM Prescription: Shu Gan Jian Wei Infusion



Prescription Description
Prescription IDTCMF5285
Pinyin NameShu Gan Jian Wei Chong Ji
Chinese Name舒肝健胃冲剂
English NameShu Gan Jian Wei Infusion
Function Description胃脘痛, 积滞
IndicationsStomach ache disorder, Dyspepsia
Disease ICD-11 Category SA51 [Stomach ache disorder (TM1), 胃脘痛 (TM1) ];
MD92 [Dyspepsia, 消化不良 ];
Human Tissues Associated with IndicationIntestine, Stomach, Spleen
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH890 Cortex magnoliae officinalis 厚朴 TCMH890 ITSAM1591-14
TCMH2265 Cyperus rotundus 香附 TCMH2265 GENG1049-15
TCMH1742 Cinnamomum cassia 肉桂 TCMH1742 GQ255631
TCMH1026 Gallus gallus domesticus 鸡内金 TCMH1026 ACLB009-06
TCMH214 Alpinia katsumadai 草豆蔻 TCMH214 KY454001
TCMH228 Bupleurum chinense 柴胡 TCMH228 ITSAM2218-14
TCMH104 Paeonia lactiflora 白芍 TCMH104 ITSAH2416-14
TCMH1695 Pericarpium citri reticulatae viride 青皮 TCMH1695
TCMH1429 NA 麦曲 TCMH1429
TCMH1662 Pharbitis nil 牵牛子 TCMH1662
TCMH2188 Trogopterus xanthipes 五灵脂 TCMH2188
TCMH1317 Gentiana scabra 龙胆 TCMH1317 ITSAP4208-14
TCMH363 Rheum officinale 大黄 TCMH363 ITSAJ4685-14
TCMH1240 Raphanus sativus 莱菔子 TCMH1240 ITSAD4259-14
TCMH243 Pericarpium citri reticulatae 陈皮 TCMH243
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT114 CNR2 Cannabinoid CB2 receptor GPCR P34972
TCMT115 CNR1 Cannabinoid CB1 receptor GPCR P21554
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT151 PRKCA Protein kinase C alpha Kinase P17252
TCMT152 PRKCB Protein kinase C beta Kinase P05771
TCMT153 PRKCG Protein kinase C gamma Kinase P05129
TCMT154 PRKCD Protein kinase C delta Kinase Q05655
TCMT155 PRKCE Protein kinase C epsilon Kinase Q02156
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT160 HTR7 Serotonin 7 (5-HT7) receptor GPCR P34969
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT303 KCNA3 Voltage-gated potassium channel subunit Kv1.3 Ion channel P22001
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT313 HTR2B Serotonin 2b (5-HT2b) receptor GPCR P41595
TCMT314 HTR2C Serotonin 2c (5-HT2c) receptor GPCR P28335
TCMT315 HTR6 Serotonin 6 (5-HT6) receptor GPCR P50406
TCMT318 HKDC1 Putative hexokinase HKDC1 Transferase Q2TB90
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT36 HTR1A Serotonin 1a (5-HT1a) receptor GPCR P08908
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT37 HTR2A Serotonin 2a (5-HT2a) receptor GPCR P28223
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT508 SYK Tyrosine-protein kinase SYK Kinase P43405
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT598 TOP1 DNA topoisomerase I Isomerase P11387
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT64 PPARD Peroxisome proliferator-activated receptor delta Nuclear receptor Q03181
TCMT645 HTR1E Serotonin 1e (5-HT1e) receptor GPCR P28566
TCMT646 HTR5A Serotonin 5a (5-HT5a) receptor GPCR P47898
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT678 XIAP Inhibitor of apoptosis protein 3 Transferase P98170
TCMT679 MPEG1 Macrophage-expressed gene 1 protein Unclassified Q2M385
TCMT680 KAT2B Histone acetyltransferase PCAF Transferase Q92831
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT729 PIK3CA PI3-kinase p110-alpha subunit Transferase P42336
TCMT730 PIK3CB PI3-kinase p110-beta subunit Transferase P42338
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT815 HTR1D Serotonin 1d (5-HT1d) receptor GPCR P28221
TCMT816 HTR1B Serotonin 1b (5-HT1b) receptor GPCR P28222
TCMT817 HTR4 Serotonin 4 (5-HT4) receptor GPCR Q13639
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1183 Candida albicans SC5314
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1201 Staphylococcus epidermidis ATCC 12228
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1243 Aspergillus flavus
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1286 Bacillus cereus
TCMT1292 Japanese encephalitis virus
TCMT1294 Human parainfluenza virus 3
TCMT1297 Punta Toro virus
TCMT1318 Human T-lymphotropic virus 1
TCMT1321 Staphylococcus hominis
TCMT1336 Yellow fever virus
TCMT1337 Dengue virus type 4
TCMT1338 Rift Valley fever virus
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0065008 regulation of biological quality ACHE, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA12, CA2, CA7, CNR1, CNR2, CYP19A1, CYP1A1, CYP1B1, EGFR, ESR1, F10, FABP3, FABP4, FLT3, GPR35, HSD11B1, HSD11B2, HSD17B2, HSPA1A, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR4, HTR7, INSR, KDR, MET, PIK3CA, PIK3CB, PPARA, PPARD, PRKCA, PRKCB, PRKCD, PRKCE, PTGS1, PTGS2, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 17.0404
[BP] GO:0042221 response to chemical AKR1B1, ALOX15, ALPL, AXL, BCL2, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, HSPA1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR5A, IGF1R, INSR, KDR, MMP2, MMP9, PIK3CA, PPARA, PPARD, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, SMAD3, SRC, TEK, TOP1, TYR 17.0404
[BP] GO:0007210 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 16.7127
[BP] GO:0098664 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 16.7127
[BP] GO:0010033 response to organic substance AKR1B1, ALOX15, ALPL, AXL, BCL2, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, HSPA1A, HTR1B, HTR5A, IGF1R, INSR, KDR, MMP2, PIK3CA, PPARA, PPARD, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, SMAD3, SRC, TEK, TYR 15.4644
[BP] GO:0010647 positive regulation of cell communication AKR1B1, ALOX15, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, FLT3, GPR35, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, INSR, KDR, MET, MMP9, PIK3CA, PIK3CB, PPARD, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 14.4918
[BP] GO:0023056 positive regulation of signaling AKR1B1, ALOX15, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, FLT3, GPR35, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, INSR, KDR, MET, MMP9, PIK3CA, PIK3CB, PPARD, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 14.4733
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, AXL, BCL2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP3, HSD11B2, HSD17B2, HTR1B, HTR5A, IGF1R, INSR, MMP2, MMP9, PIK3CA, PPARA, PPARD, PRKCB, PRKCD, PRKCE, PTGS2, SRC, TEK, TYR 14.0468
[BP] GO:0009967 positive regulation of signal transduction AKR1B1, ALOX15, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, F10, FLT3, GPR35, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, INSR, KDR, MET, MMP9, PIK3CA, PIK3CB, PPARD, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 12.9396
[BP] GO:0010646 regulation of cell communication ACHE, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, F10, FLT3, GPR35, HSPA1A, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PPARD, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 12.4975
[BP] GO:1902531 regulation of intracellular signal transduction AKR1B1, ALOX15, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, F10, FLT3, GPR35, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PPARD, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, SRC, TEK, XDH 12.4381
[BP] GO:0023051 regulation of signaling ACHE, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, F10, FLT3, GPR35, HSPA1A, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PPARD, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 12.3605
[BP] GO:1902533 positive regulation of intracellular signal transduction AKR1B1, ALOX15, AXL, BCL2, CYP1B1, EGFR, F10, FLT3, GPR35, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, INSR, KDR, MET, PIK3CA, PIK3CB, PPARD, PRKCA, PRKCB, PRKCE, PTGS2, SRC, TEK, XDH 12.3553
[BP] GO:0048584 positive regulation of response to stimulus AKR1B1, ALOX15, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, EGFR, F10, FABP4, FLT3, GPR35, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PPARD, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 11.8324
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, EGFR, ESR1, FABP3, FLT3, HSD11B2, HSD17B2, HTR1B, HTR5A, PPARD, PRKCE, PTGS2, SRC, TYR 11.3075
[BP] GO:0032501 multicellular organismal process AKR1B1, ALOX15, ALOX5, ALPL, AXL, BCL2, CNR1, CNR2, CYP19A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, F10, FABP4, HSD11B2, HSD17B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR7, IGF1R, INSR, MET, MMP1, MMP2, MMP9, PIK3CA, PIM1, PPARA, PPARD, PRKCD, PRKCG, PTGS2, SMAD3, SRC, TEK, TNKS2, TOP1, TYR 10.6622
[BP] GO:0050896 response to stimulus ACHE, ADORA3, AKR1B1, ALOX15, ALPL, AURKB, AXL, BCL2, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, F10, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, HSPA1A, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR5A, IGF1R, INSR, KDR, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PPARD, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, SMAD3, SRC, TEK, TOP1, TYR 10.6549
[BP] GO:0042493 response to drug AKR1B1, AXL, BCL2, CA9, CNR1, CNR2, CYP1A1, CYP1B1, EGFR, FABP3, HSD11B2, HTR1B, HTR2A, HTR2B, HTR2C, KDR, PRKCD, PRKCE, PRKCG, PTGS2, SRC, TOP1 10.1731
[BP] GO:0009725 response to hormone AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, FABP3, FLT3, HSD11B2, HTR1B, HTR5A, INSR, PPARA, PRKCD, PRKCE, PTGS2, SRC, TEK 10.1166
[BP] GO:0032879 regulation of localization ACHE, ADORA3, ALOX15, AXL, BCL2, CA2, CA7, CNR1, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, GPR35, HSPA1A, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KCNA3, KDR, MET, MMP9, PIK3CB, PPARA, PPARD, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, SMAD3, SRC, TEK 10.1166
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, ALPL, AURKB, AXL, BCL2, CSNK2A1, DUSP3, EGFR, FLT3, HSPA1A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PPARD, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, SRC, TEK, TNKS, TOP1, XDH 9.97888
[BP] GO:0048522 positive regulation of cellular process ACHE, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, F10, FABP3, FLT3, GPR35, HSPA1A, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PPARD, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 9.76786
[BP] GO:0048583 regulation of response to stimulus AKR1B1, ALOX15, AURKB, AXL, BCL2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, F10, FABP4, FLT3, GPR35, HSPA1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, MET, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PPARD, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 9.67572
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, FABP3, FLT3, HSD11B2, HTR1B, HTR5A, IGF1R, INSR, MMP2, PPARA, PRKCD, PRKCE, PTGS2, SMAD3, SRC, TEK 9.5827
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, ALPL, AURKB, AXL, BCL2, CSNK2A1, DUSP3, EGFR, FLT3, HSPA1A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PPARD, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, SRC, TEK, TNKS, TOP1, XDH 9.48253
[BP] GO:0014070 response to organic cyclic compound ALPL, BCL2, CA2, CA9, CNR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FLT3, HSD11B2, HTR1B, HTR5A, PRKCE, PRKCG, PTGS2, SRC, TEK, TYR 9.41717
[BP] GO:0006468 protein phosphorylation AURKB, AXL, BCL2, CSNK2A1, EGFR, FLT3, HTR2B, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TNKS, TOP1 9.16517
[BP] GO:0060548 negative regulation of cell death AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, HSPA1A, HTR2B, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PPARA, PPARD, PRKCA, PRKCD, PRKCG, PTGS2, SMAD3, SRC, TEK 9.03404
[BP] GO:0042127 regulation of cell proliferation ADORA3, AKR1B1, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, FABP3, FLT3, HSPA1A, HTR1A, HTR1B, HTR2A, HTR2B, IGF1R, INSR, KDR, MMP2, MMP9, NUAK1, PIM1, PPARD, PRKCA, PTGS1, PTGS2, SMAD3, SRC, TEK, XDH 8.93452
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, PPARA, PRKCD, PRKCE, PTGS2, SRC, TEK 8.93086
[BP] GO:0043069 negative regulation of programmed cell death AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, HSPA1A, HTR2B, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PPARD, PRKCA, PRKCD, PRKCG, PTGS2, SMAD3, SRC, TEK 8.93086
[BP] GO:0010941 regulation of cell death AKR1B1, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, HSPA1A, HTR2B, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PPARD, PRKCA, PRKCD, PRKCG, PTGS2, SMAD3, SRC, TEK, XDH 8.93086
[BP] GO:0043067 regulation of programmed cell death AKR1B1, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, HSPA1A, HTR2B, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARD, PRKCA, PRKCD, PRKCG, PTGS2, SMAD3, SRC, TEK, XDH 8.91719
[BP] GO:0006629 lipid metabolic process ACHE, AKR1B1, ALOX15, ALOX5, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP3, FABP4, FUT7, HSD11B1, HSD11B2, HSD17B2, MET, PIK3CA, PIK3CB, PPARA, PPARD, PTGS1, PTGS2 8.70795
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, PRKCD, SRC, TEK 8.57682
[BP] GO:0051049 regulation of transport ACHE, ALOX15, AXL, BCL2, CA2, CA7, CNR1, CYP19A1, EGFR, GPR35, HSPA1A, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, INSR, KCNA3, MMP9, PIK3CB, PPARA, PPARD, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, SMAD3, SRC 8.43303
[BP] GO:0048518 positive regulation of biological process ACHE, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, F10, FABP3, FABP4, FLT3, GPR35, HSPA1A, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PPARD, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 8.41852
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALOX15, ALPL, AXL, BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP4, FLT3, HSPA1A, HTR1B, IGF1R, INSR, KDR, MMP2, MMP9, PIK3CA, PPARD, PRKCB, PRKCD, PRKCE, PTGS2, SMAD3, SRC 8.40894
[BP] GO:0016310 phosphorylation AURKB, AXL, BCL2, CSNK2A1, EGFR, FLT3, HTR2B, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TNKS, TOP1 8.33441
[BP] GO:0042981 regulation of apoptotic process AKR1B1, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, HSPA1A, HTR2B, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PIM1, PPARD, PRKCA, PRKCD, PRKCG, PTGS2, SMAD3, SRC, TEK, XDH 8.29756
[BP] GO:0043066 negative regulation of apoptotic process AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, HSPA1A, HTR2B, IGF1R, KDR, MMP9, PIK3CA, PIM1, PPARD, PRKCA, PRKCD, PRKCG, PTGS2, SMAD3, SRC, TEK 8.26291
[BP] GO:0009966 regulation of signal transduction AKR1B1, ALOX15, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, F10, FLT3, GPR35, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PPARD, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 8.26291
[BP] GO:0010817 regulation of hormone levels ACHE, AKR1B1, CNR1, CYP19A1, CYP1A1, CYP1B1, EGFR, ESR1, HSD11B1, HSD11B2, HSD17B2, HTR1A, HTR2A, HTR2C, PPARD, PRKCA, PRKCE 8.26291
[BP] GO:0003018 None EGFR, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PPARD, PTGS2, SRC, TEK 7.99159
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALOX15, ALPL, AXL, BCL2, CYP1A1, CYP1B1, EGFR, ESR1, FABP4, FLT3, HTR1B, IGF1R, INSR, KDR, MMP2, PIK3CA, PPARD, PRKCB, PRKCD, PRKCE, PTGS2, SMAD3, SRC 7.90226
[BP] GO:0032844 regulation of homeostatic process AURKB, BCL2, CA2, CA7, CNR1, EGFR, HTR2A, HTR2B, HTR2C, KDR, PIK3CB, PRKCE, PTGS2, SRC, TNKS, TNKS2 7.72376
[BP] GO:0019220 regulation of phosphate metabolic process ALOX15, BCL2, DUSP3, EGFR, FABP3, FABP4, FLT3, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PTGS2, SMAD3, SRC, TEK, XDH 7.70676
[BP] GO:0051174 regulation of phosphorus metabolic process ALOX15, BCL2, DUSP3, EGFR, FABP3, FABP4, FLT3, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PTGS2, SMAD3, SRC, TEK, XDH 7.63141
[BP] GO:0048878 chemical homeostasis AKR1B1, BCL2, CA12, CA2, CA7, CNR1, EGFR, ESR1, FABP3, FABP4, GPR35, HTR2A, HTR2B, HTR2C, INSR, MET, PIK3CA, PIK3CB, PRKCB, PRKCE, SMAD3 7.52747
[BP] GO:0010243 response to organonitrogen compound AKR1B1, CNR1, CNR2, EGFR, FABP3, FLT3, HSD11B2, HTR1B, IGF1R, INSR, MMP2, PPARA, PRKCD, PRKCE, PRKCG, PTGS2, SRC, TEK, TYR 7.41552
[BP] GO:0097756 None HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 7.2715
[BP] GO:0007165 signal transduction ADORA3, AKR1B1, AXL, BCL2, CA2, CNR1, CNR2, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, GPR35, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PPARD, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SMAD3, SRC, TEK, TNKS, TNKS2 7.26753
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, EGFR, F10, FLT3, IGF1R, INSR, KDR, MET, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TNKS, TOP1 7.26136
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CSNK2A1, EGFR, ESR1, FLT3, HTR1A, HTR1B, HTR2A, HTR2B, IGF1R, INSR, KDR, MMP2, MMP9, PIM1, PPARD, PRKCA, PTGS2, TEK 7.20644
[BP] GO:0007198 None HTR1A, HTR1B, HTR5A, HTR7 7.16874
[BP] GO:0009628 response to abiotic stimulus AKR1B1, AURKB, BCL2, CA2, CYP1A1, EGFR, HSD11B2, HSPA1A, HTR1B, HTR2A, HTR2B, MMP2, PPARA, PPARD, PRKCB, PRKCE, PTGS2, SMAD3, SRC, TEK, TYR 7.0978
[BP] GO:0042592 homeostatic process AKR1B1, AXL, BCL2, CA12, CA2, CA7, CNR1, EGFR, ESR1, FABP3, FABP4, FLT3, GPR35, HTR2A, HTR2B, HTR2C, INSR, MET, PIK3CA, PIK3CB, PRKCB, PRKCE, SMAD3, SRC 7.00675
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, PIM1, PRKCG, SRC, TEK 7.00516
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, KDR, MMP9, PRKCD, PTGS2, SRC 6.96749
[BP] GO:1901698 response to nitrogen compound AKR1B1, CNR1, CNR2, EGFR, FABP3, FLT3, HSD11B2, HTR1B, IGF1R, INSR, MMP2, PPARA, PRKCD, PRKCE, PRKCG, PTGS2, SRC, TEK, TYR 6.94437
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, PRKCD, SRC, TEK 6.93906
[BP] GO:0001666 response to hypoxia BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PPARD, PRKCB, PRKCE, PTGS2, SMAD3, SRC, TEK 6.90583
[BP] GO:0030168 platelet activation AXL, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC 6.85215
[BP] GO:0003013 None EGFR, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PPARD, PTGS2, SRC, TEK 6.84185
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, BCL2, CNR1, CNR2, CYP1A1, CYP1B1, HTR1B, HTR1D, KDR, PRKCD, PRKCE, SRC 6.79636
[BP] GO:0036293 response to decreased oxygen levels BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PPARD, PRKCB, PRKCE, PTGS2, SMAD3, SRC, TEK 6.77816
[BP] GO:0032502 developmental process ACHE, AKR1B1, ALOX15, ALPL, AURKB, AXL, BCL2, CA2, CA9, CBR1, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, FABP4, FLT3, FUT7, HSD11B1, HSD17B2, HTR2A, HTR2B, HTR5A, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PPARD, PRKCA, PRKCD, PTGS2, SMAD3, SRC, TEK, TNKS2, TYR 6.73317
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ESR1, FLT3, HSD11B1, HSD17B2, INSR, KDR, PIK3CA, PPARA, PPARD, SMAD3, SRC, TEK, TYR 6.65714
[BP] GO:0018105 peptidyl-serine phosphorylation AURKB, BCL2, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TNKS, TOP1 6.58258
[BP] GO:0030334 regulation of cell migration ADORA3, BCL2, CYP19A1, CYP1B1, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, PPARD, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TEK 6.55463
[BP] GO:0044281 small molecule metabolic process AKR1B1, ALOX15, ALOX5, CA12, CA2, CA4, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FUT7, HSPA1A, HTR2B, HTR2C, PIK3CA, PIM1, PPARA, PPARD, PTGS1, PTGS2, TYR, XDH 6.51003
[BP] GO:0042310 None HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7 6.47862
[BP] GO:0010562 positive regulation of phosphorus metabolic process ALOX15, BCL2, EGFR, FABP3, FLT3, HTR2A, HTR2B, HTR2C, INSR, KDR, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, SMAD3, SRC, TEK, XDH 6.47862
[BP] GO:0045937 positive regulation of phosphate metabolic process ALOX15, BCL2, EGFR, FABP3, FLT3, HTR2A, HTR2B, HTR2C, INSR, KDR, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, SMAD3, SRC, TEK, XDH 6.47862
[BP] GO:0097746 None EGFR, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PPARD, PTGS2 6.45627
[BP] GO:0035296 None EGFR, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PPARD, PTGS2 6.45627
[BP] GO:0040012 regulation of locomotion ADORA3, BCL2, CYP19A1, CYP1B1, EGFR, F10, HTR1D, IGF1R, INSR, KDR, MET, MMP9, PPARD, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TEK 6.44321
[BP] GO:0070482 response to oxygen levels BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PPARD, PRKCB, PRKCE, PTGS2, SMAD3, SRC, TEK 6.41279
[BP] GO:0019369 arachidonic acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 6.40152
[BP] GO:0019216 regulation of lipid metabolic process CNR1, CYP1A1, FABP3, FLT3, HTR2A, HTR2B, HTR2C, PPARA, PRKCD, PRKCE, PTGS2, SRC, TEK 6.37731
[BP] GO:0030335 positive regulation of cell migration BCL2, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TEK 6.34048
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA3, AKR1B1, AURKB, AXL, BCL2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, FABP3, FABP4, GPR35, HSPA1A, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PPARA, PPARD, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 6.26653
[BP] GO:0032228 regulation of synaptic transmission, GABAergic CA2, CA7, CNR1, CNR2, HTR1B, PRKCE 6.25357
[BP] GO:0050880 None EGFR, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PPARD, PTGS2 6.24988
[BP] GO:0043408 regulation of MAPK cascade ALOX15, DUSP3, EGFR, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, PIK3CB, PRKCA, PRKCD, PRKCE, SRC, TEK, XDH 6.23656
[BP] GO:0035150 None EGFR, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PPARD, PTGS2 6.22821
[BP] GO:0007187 None CNR1, CNR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR4, HTR5A, HTR6, HTR7 6.22515
[BP] GO:0018209 peptidyl-serine modification AURKB, BCL2, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TNKS, TOP1 6.20588
[BP] GO:2000145 regulation of cell motility ADORA3, BCL2, CYP19A1, CYP1B1, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, PPARD, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TEK 6.19988
[BP] GO:2000147 positive regulation of cell motility BCL2, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TEK 6.17977
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, PRKCD, SRC, TEK 6.17118
[BP] GO:0044092 negative regulation of molecular function ADORA3, AURKB, CNR1, CNR2, CSNK2A1, CYP1B1, DUSP3, ESR1, FABP4, GPR35, IGF1R, MET, MMP9, PIM1, PPARA, PRKCA, PRKCD, PRKCE, PTGS2, SRC, TNKS 6.11555
[BP] GO:0018212 peptidyl-tyrosine modification AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, PRKCD, SRC, TEK 6.11454
[BP] GO:0001934 positive regulation of protein phosphorylation ALOX15, BCL2, EGFR, FLT3, HTR2A, HTR2B, HTR2C, INSR, KDR, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, SRC, TEK, XDH 6.07959
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 6.04896
[BP] GO:0051272 positive regulation of cellular component movement BCL2, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TEK 6.04896
[BP] GO:0008283 cell proliferation ACHE, AURKB, BCL2, CYP1A1, EGFR, ESR1, FLT3, HTR1A, MET, PIK3CB, PIM1, PPARD, PRKCD, SRC, TEK, TYR 5.98667
[BP] GO:0044255 cellular lipid metabolic process ACHE, ALOX15, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, FABP4, FUT7, MET, PIK3CA, PIK3CB, PPARA, PPARD, PTGS1, PTGS2 5.96007
[BP] GO:0050790 regulation of catalytic activity ADORA3, AURKB, BCL2, CNR1, CNR2, CSNK2A1, DUSP3, EGFR, ESR1, FABP4, FLT3, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, MMP9, NUAK1, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, SMAD3, SRC, TEK, TNKS, XDH 5.8873
[BP] GO:0040017 positive regulation of locomotion BCL2, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TEK 5.8668
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, ALOX15, ALOX5, ALPL, AURKB, AXL, BCL2, CA12, CA2, CA4, CA7, CA9, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, F10, FABP3, FABP4, FLT3, FUT7, HSD17B2, HSPA1A, HTR1A, HTR1B, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MMP1, MMP2, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PPARD, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, SMAD3, SRC, TEK, TNKS, TNKS2, TOP1, TYR, XDH 5.86411
[BP] GO:0080134 regulation of response to stress CNR1, CNR2, CYP19A1, DUSP3, EGFR, ESR1, FABP4, HSPA1A, IGF1R, MET, MMP2, NUAK1, PPARA, PPARD, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, SMAD3, SRC, TEK, XDH 5.85397
[BP] GO:0006690 icosanoid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 5.83357
[BP] GO:0008152 metabolic process ACHE, AKR1B1, ALOX15, ALOX5, ALPL, AURKB, AXL, BCL2, CA12, CA2, CA4, CA7, CA9, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, F10, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD11B2, HSD17B2, HSPA1A, HTR1A, HTR1B, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PPARD, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, SMAD3, SRC, TEK, TNKS, TNKS2, TOP1, TYR, XDH 5.81671
[BP] GO:0006950 response to stress ACHE, ADORA3, AKR1B1, ALOX15, AXL, BCL2, CA2, CA9, CNR2, CYP1A1, CYP1A2, CYP1B1, EGFR, HSD11B2, HSPA1A, HTR1A, HTR2C, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PPARD, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, SMAD3, SRC, TEK 5.81671
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALOX15, ALPL, AURKB, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP4, FLT3, HSPA1A, HTR1B, IGF1R, INSR, KDR, MMP2, MMP9, NUAK1, PIK3CA, PPARD, PRKCB, PRKCD, PRKCE, PTGS2, SMAD3, SRC 5.81671
[BP] GO:0042327 positive regulation of phosphorylation ALOX15, BCL2, EGFR, FLT3, HTR2A, HTR2B, HTR2C, INSR, KDR, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, SRC, TEK, XDH 5.809
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, F10, INSR, MET, PIK3CA, PIK3CB, SRC, TEK 5.79434
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PRKCA, SRC, TEK 5.77519
[BP] GO:0051270 regulation of cellular component movement ADORA3, BCL2, CYP19A1, CYP1B1, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, PPARD, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TEK 5.71714
[BP] GO:0051896 regulation of protein kinase B signaling AXL, EGFR, F10, INSR, MET, PIK3CA, PIK3CB, SRC, TEK, XDH 5.7165
[BP] GO:0031399 regulation of protein modification process ALOX15, BCL2, DUSP3, EGFR, FABP4, FLT3, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, SRC, TEK, XDH 5.68126
[BP] GO:0042325 regulation of phosphorylation ALOX15, BCL2, DUSP3, EGFR, FABP4, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MMP9, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PTGS2, SRC, TEK, XDH 5.66062
[BP] GO:0043410 positive regulation of MAPK cascade ALOX15, EGFR, FLT3, HTR2A, HTR2B, HTR2C, INSR, KDR, PIK3CB, PRKCA, PRKCE, SRC, TEK, XDH 5.66062
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA3, AKR1B1, ALOX15, AURKB, AXL, BCL2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, FABP3, FABP4, GPR35, HSPA1A, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PPARA, PPARD, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 5.64574
[BP] GO:0001932 regulation of protein phosphorylation ALOX15, BCL2, DUSP3, EGFR, FABP4, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, SRC, TEK, XDH 5.64408
[BP] GO:0065009 regulation of molecular function ADORA3, AURKB, BCL2, CNR1, CNR2, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, FABP4, FLT3, GPR35, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, SMAD3, SRC, TEK, TNKS, XDH 5.64408
[BP] GO:0009894 regulation of catabolic process BCL2, CNR1, CSNK2A1, EGFR, HSPA1A, HTR2A, HTR2B, INSR, KDR, MET, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, SMAD3 5.58552
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AURKB, AXL, BCL2, CSNK2A1, CYP1A1, CYP1A2, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, HSPA1A, HTR1A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NUAK1, PIK3CA, PIM1, PPARA, PPARD, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, SMAD3, SRC, TEK, TNKS, TNKS2, TOP1, TYR, XDH 5.51995
[BP] GO:0015701 bicarbonate transport CA12, CA14, CA2, CA4, CA7, CA9 5.51015
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA3, CA2, CNR1, CNR2, ESR1, GPR35, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, INSR, PIK3CA, PIK3CB, SRC 5.45949
[BP] GO:0051130 positive regulation of cellular component organization ALOX15, AURKB, AXL, BCL2, CNR1, ESR1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, PRKCD, PRKCE, SMAD3, SRC, TEK, TNKS, TNKS2 5.42469
[BP] GO:0090066 None ALOX15, EGFR, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PPARD, PRKCD, PRKCE, PTGS2 5.42462
[BP] GO:0006631 fatty acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, PPARA, PPARD, PTGS1, PTGS2 5.41773
[BP] GO:0071073 None FABP3, HTR2A, HTR2B, HTR2C 5.3896
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PRKCA, PRKCE, PTGS2, SRC, TEK 5.28158
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX15, CSNK2A1, CYP19A1, CYP1A1, HSD11B1, HSD11B2, HSD17B2, PIK3CA, PIK3CB, PPARD, PTGS1, PTGS2 5.2762
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, BCL2, CYP1A1, EGFR, PPARA, PPARD, SMAD3 5.24486
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, AXL, CYP1B1, EGFR, ESR1, IGF1R, INSR, MMP2, MMP9, PIK3CA, PPARD, PRKCB, PRKCD, PRKCE, PTGS2, SRC 5.22905
[BP] GO:0050727 regulation of inflammatory response CNR1, CNR2, CYP19A1, EGFR, ESR1, FABP4, PPARA, PPARD, PRKCD, PTGS2, SMAD3, TEK 5.20661
[BP] GO:0019748 secondary metabolic process AKR1B1, BCL2, CYP1A1, CYP1A2, CYP1B1, TYR 5.14767
[BP] GO:0008202 steroid metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B2, PPARD 5.13746
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B2 5.1369
[BP] GO:0051247 positive regulation of protein metabolic process ALOX15, BCL2, CSNK2A1, EGFR, ESR1, FLT3, HSPA1A, HTR2A, HTR2B, HTR2C, INSR, KDR, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, SMAD3, SRC, TEK, XDH 5.13472
[BP] GO:0050801 ion homeostasis BCL2, CA12, CA2, CA7, EGFR, ESR1, FABP3, GPR35, HTR2A, HTR2B, HTR2C, PIK3CB, PRKCB, PRKCE, SMAD3 5.11074
[BP] GO:0030155 regulation of cell adhesion ALOX15, BCL2, CYP1B1, DUSP3, KDR, NUAK1, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, SMAD3, SRC, TEK 5.11074
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PRKCA, SMAD3, SRC, TEK 5.07108
[BP] GO:0032101 regulation of response to external stimulus CNR1, CNR2, CYP19A1, EGFR, ESR1, FABP4, KDR, MET, PPARA, PPARD, PRKCA, PRKCD, PRKCG, PTGS2, SMAD3, TEK 5.02248
[BP] GO:0055114 oxidation-reduction process AKR1B1, ALOX15, ALOX5, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B1, HSD11B2, HSD17B2, NQO2, PPARD, PTGS1, PTGS2, TYR, XDH 4.99928
[BP] GO:0031347 regulation of defense response CNR1, CNR2, CYP19A1, EGFR, ESR1, FABP4, HSPA1A, MMP2, PPARA, PPARD, PRKCD, PRKCE, PTGS2, SMAD3, SRC, TEK 4.99849
[BP] GO:0003008 None AKR1B1, BCL2, CNR1, CNR2, CYP1B1, EGFR, HSD11B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, INSR, PIK3CA, PPARD, PRKCG, PTGS2, SRC, TEK, TYR 4.97848
[BP] GO:0035556 intracellular signal transduction AKR1B1, AXL, BCL2, CYP1B1, EGFR, HTR2A, HTR2B, HTR5A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK 4.94124
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade ALOX15, EGFR, HTR2A, HTR2B, HTR2C, KDR, PRKCA, SRC, TEK 4.93442
[BP] GO:0043271 negative regulation of ion transport BCL2, CNR1, GPR35, HTR1B, HTR2A, MMP9, PRKCE, PTGS2 4.92874
[BP] GO:0032270 positive regulation of cellular protein metabolic process ALOX15, BCL2, EGFR, ESR1, FLT3, HSPA1A, HTR2A, HTR2B, HTR2C, INSR, KDR, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, SMAD3, SRC, TEK, XDH 4.92833
[BP] GO:0032845 None BCL2, HTR2A, HTR2B, HTR2C, PRKCE, SRC, TNKS, TNKS2 4.86489
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ALOX15, AURKB, BCL2, CSNK2A1, EGFR, ESR1, FLT3, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MMP9, PIK3CA, PIK3CB, PPARA, PPARD, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 4.84405
[BP] GO:0006979 response to oxidative stress AKR1B1, AXL, BCL2, CYP1B1, EGFR, HSPA1A, MMP9, PRKCD, PTGS1, PTGS2, SRC 4.83943
[BP] GO:0014065 phosphatidylinositol 3-kinase signaling HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB 4.7764
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ALOX15, DUSP3, EGFR, HTR2A, HTR2B, HTR2C, KDR, PRKCA, SRC, TEK 4.76954
[BP] GO:0010638 positive regulation of organelle organization ALOX15, AURKB, BCL2, HSPA1A, INSR, KDR, MET, MMP9, PRKCE, SMAD3, SRC, TEK, TNKS, TNKS2 4.76954
[BP] GO:2000021 regulation of ion homeostasis BCL2, CA2, CA7, HTR2A, HTR2B, HTR2C, KDR, PRKCE, SRC 4.75669
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 4.75669
[BP] GO:0016477 cell migration AXL, CNR2, CYP1B1, EGFR, FUT7, HTR2B, HTR6, KDR, MMP1, MMP9, PIK3CA, PIK3CB, PPARD, PRKCD, SRC, TEK 4.68849
[BP] GO:0051054 positive regulation of DNA metabolic process AURKB, EGFR, IGF1R, INSR, PRKCD, PRKCG, SRC, TNKS, TNKS2 4.675
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, EGFR, HTR1B, KDR, PRKCD, PRKCE, PTGS2, SRC 4.66672
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, EGFR, FLT3, HSD11B2, HTR1B, PTGS2, SRC 4.6451
[BP] GO:1901568 fatty acid derivative metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 4.6451
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, EGFR, ESR1, HTR7, PPARA, PRKCG, SRC, TOP1 4.64482
[BP] GO:0001775 cell activation ALOX5, AXL, BCL2, EGFR, FLT3, FUT7, HSPA1A, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SMAD3, SRC 4.62761
[BP] GO:0046889 None FABP3, HTR2A, HTR2B, HTR2C, PRKCD, PTGS2 4.62761
[BP] GO:0050795 None CNR1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B 4.62761
[BP] GO:0007610 None BCL2, CNR1, EGFR, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, INSR, PPARA, PRKCE, PRKCG, PTGS2 4.61243
[BP] GO:0031401 positive regulation of protein modification process ALOX15, BCL2, EGFR, FLT3, HTR2A, HTR2B, HTR2C, INSR, KDR, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, SRC, TEK, XDH 4.59982
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, HTR2A, INSR, MET, SMAD3, SRC 4.59625
[BP] GO:0048545 response to steroid hormone ALPL, BCL2, CA2, EGFR, FLT3, HSD11B2, HTR1B, PTGS2, SRC 4.59625
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.58382
[BP] GO:0098771 inorganic ion homeostasis BCL2, CA12, CA2, CA7, EGFR, ESR1, GPR35, HTR2A, HTR2B, HTR2C, PIK3CB, PRKCB, PRKCE, SMAD3 4.58192
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, EGFR, MMP9, PRKCD, SRC 4.56502
[BP] GO:0051239 regulation of multicellular organismal process ADORA3, AXL, BCL2, CA2, CNR1, CYP1B1, EGFR, ESR1, GPR35, HSPA1A, HTR2A, HTR2B, HTR2C, INSR, KDR, MET, MMP9, PIK3CA, PIM1, PPARD, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, SMAD3, SRC, TEK, TNKS2, XDH 4.56116
[BP] GO:0048585 negative regulation of response to stimulus ALOX15, BCL2, CNR1, CNR2, CYP19A1, DUSP3, EGFR, ESR1, HSPA1A, IGF1R, MET, MMP9, PPARA, PPARD, PRKCB, PRKCD, PTGS2, SMAD3, SRC, TEK, XDH 4.54311
[BP] GO:0031325 positive regulation of cellular metabolic process ALOX15, AURKB, BCL2, EGFR, ESR1, FABP3, FLT3, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MMP9, PIK3CA, PIK3CB, PPARA, PPARD, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 4.52868
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, CNR1, EGFR, PIK3CB, PTGS2, TNKS, TNKS2 4.49913
[BP] GO:0006730 one-carbon metabolic process CA12, CA2, CA4, CA7, CA9 4.49427
[BP] GO:0010604 positive regulation of macromolecule metabolic process ALOX15, AURKB, BCL2, CSNK2A1, EGFR, ESR1, FLT3, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MMP9, PIK3CA, PIK3CB, PPARA, PPARD, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 4.48294
[BP] GO:0099536 None CNR1, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, PRKCG 4.47977
[BP] GO:0099537 None CNR1, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, PRKCG 4.47977
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, CA2, CA7, CNR1, CNR2, EGFR, HTR1B, HTR2A, PRKCE, PTGS2 4.459
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, CA2, CA7, CNR1, CNR2, EGFR, HTR1B, HTR2A, PRKCE, PTGS2 4.459
[BP] GO:0001503 ossification ALOX15, ALPL, BCL2, EGFR, MMP2, MMP9, TEK 4.42843
[BP] GO:2000377 regulation of reactive oxygen species metabolic process BCL2, CYP1B1, EGFR, INSR, PRKCD, PTGS2, SMAD3, XDH 4.41423
[BP] GO:0050728 negative regulation of inflammatory response CNR2, CYP19A1, PPARA, PPARD, PRKCD, SMAD3, TEK 4.40986
[BP] GO:0065007 biological regulation ACHE, ADORA3, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA12, CA2, CA7, CA9, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, F10, FABP3, FABP4, FLT3, GPR35, HSD11B1, HSD11B2, HSD17B2, HSPA1A, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KCNA3, KDR, MET, MMP1, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PPARD, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, SMAD3, SRC, TEK, TNKS, TNKS2, TOP1, XDH 4.39981
[BP] GO:0071071 None FABP3, HTR2A, HTR2B, HTR2C 4.39252
[BP] GO:0009892 negative regulation of metabolic process AURKB, BCL2, CNR1, CNR2, CSNK2A1, DUSP3, EGFR, ESR1, FABP4, HSPA1A, HTR1B, HTR1E, HTR2B, IGF1R, KDR, MET, MMP9, PIK3CA, PPARA, PPARD, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, SMAD3, SRC, TNKS, TNKS2, XDH 4.38423
[BP] GO:0009893 positive regulation of metabolic process ALOX15, AURKB, BCL2, CSNK2A1, EGFR, ESR1, FABP3, FLT3, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MMP9, PIK3CA, PIK3CB, PPARA, PPARD, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 4.33928
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, BCL2, CYP1B1, EGFR, MMP9, PRKCD, SRC 4.32904
[BP] GO:0040011 locomotion AXL, CNR2, CYP1B1, EGFR, FUT7, HTR2B, HTR6, KDR, MET, MMP1, MMP9, PIK3CA, PIK3CB, PPARD, PRKCD, SRC, TEK 4.29368
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA3, ALOX15, AURKB, BCL2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, FABP3, FABP4, FLT3, HSPA1A, HTR1A, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PPARD, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, SMAD3, SRC, TEK, TNKS, TNKS2, TOP1, XDH 4.2724
[BP] GO:0010648 negative regulation of cell communication ACHE, BCL2, CNR2, DUSP3, EGFR, ESR1, GPR35, HSPA1A, HTR1B, HTR2A, IGF1R, MET, MMP9, PRKCB, PRKCD, PTGS2, SMAD3, SRC, XDH 4.26287
[BP] GO:0007193 None HTR1A, HTR1B, HTR1D, HTR1E, HTR5A, HTR7 4.24976
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, HTR1B, MMP2, MMP9, PTGS2 4.24976
[BP] GO:0023057 negative regulation of signaling ACHE, BCL2, CNR2, DUSP3, EGFR, ESR1, GPR35, HSPA1A, HTR1B, HTR2A, IGF1R, MET, MMP9, PRKCB, PRKCD, PTGS2, SMAD3, SRC, XDH 4.24847
[BP] GO:0010513 None HTR2A, HTR2B, HTR2C 4.24847
[BP] GO:0048870 cell motility AXL, CNR2, CYP1B1, EGFR, FUT7, HTR2B, HTR6, KDR, MMP1, MMP9, PIK3CA, PIK3CB, PPARD, PRKCD, SRC, TEK 4.2314
[BP] GO:0018107 peptidyl-threonine phosphorylation BCL2, CSNK2A1, PRKCA, PRKCB, PRKCD, TNKS 4.18969
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, EGFR, HTR1B, MMP2, MMP9, PPARD, PTGS2 4.12507
[BP] GO:0043269 regulation of ion transport BCL2, CA2, CA7, CNR1, GPR35, HTR1A, HTR1B, HTR2A, KCNA3, MMP9, PRKCD, PRKCE, PTGS2 4.10234
[BP] GO:0072507 divalent inorganic cation homeostasis BCL2, EGFR, ESR1, GPR35, HTR2A, HTR2B, HTR2C, PIK3CB, PRKCB, PRKCE, SMAD3 4.10185
[BP] GO:0010810 regulation of cell-substrate adhesion ALOX15, BCL2, KDR, PIK3CB, PRKCE, SMAD3, SRC, TEK 4.10133
[BP] GO:0032268 regulation of cellular protein metabolic process ALOX15, BCL2, CSNK2A1, DUSP3, EGFR, ESR1, FABP4, FLT3, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, SMAD3, SRC, TEK, XDH 4.08211
[BP] GO:0033273 response to vitamin ALPL, CYP1A1, EGFR, PPARD, PTGS2, TYR 4.07289
[BP] GO:0043405 regulation of MAP kinase activity DUSP3, EGFR, FLT3, HTR2A, HTR2B, IGF1R, INSR, PIK3CB, PRKCD, SRC 4.02956
[BP] GO:0009895 negative regulation of catabolic process BCL2, CNR1, EGFR, HTR2B, MET, PIK3CA, PPARA, PRKCG, SMAD3 4.01824
[BP] GO:0046883 regulation of hormone secretion CNR1, CYP19A1, EGFR, HTR1A, HTR2A, HTR2C, PPARD, PRKCA, PRKCE 4.01824
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, PRKCD, SRC 4.01054
[BP] GO:0018210 peptidyl-threonine modification BCL2, CSNK2A1, PRKCA, PRKCB, PRKCD, TNKS 3.99071
[BP] GO:0009991 response to extracellular stimulus ALPL, AXL, BCL2, CNR1, CYP1A1, EGFR, HSD11B2, PPARD, PTGS2, SRC, TYR 3.97924
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 3.97437
[BP] GO:0055080 cation homeostasis BCL2, CA2, CA7, EGFR, ESR1, GPR35, HTR2A, HTR2B, HTR2C, PIK3CB, PRKCB, PRKCE, SMAD3 3.968
[BP] GO:1901652 response to peptide AKR1B1, FABP3, HSD11B2, IGF1R, INSR, PPARA, PRKCD, PTGS2, SRC, TEK 3.94066
[BP] GO:0019538 protein metabolic process ACHE, ALPL, AURKB, AXL, BCL2, CSNK2A1, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, HTR2B, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NUAK1, PIK3CA, PIM1, PPARA, PPARD, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SMAD3, SRC, TEK, TNKS, TNKS2, TOP1 3.89337
[BP] GO:0044267 cellular protein metabolic process ALPL, AURKB, AXL, BCL2, CSNK2A1, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, HTR2B, IGF1R, INSR, KDR, MET, MMP1, MMP2, NUAK1, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SMAD3, SRC, TEK, TNKS, TNKS2, TOP1 3.8781
[BP] GO:0048856 anatomical structure development ACHE, AKR1B1, ALOX15, ALPL, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, FLT3, HSD11B1, HSD17B2, HTR5A, INSR, KDR, MMP9, PIK3CA, PIM1, PPARA, PPARD, PTGS2, SMAD3, SRC, TEK, TYR 3.8674
[BP] GO:2000379 positive regulation of reactive oxygen species metabolic process EGFR, INSR, PRKCD, PTGS2, SMAD3, XDH 3.85915
[BP] GO:0032496 response to lipopolysaccharide ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, PPARD, PTGS2, SRC 3.85199
[BP] GO:0055082 cellular chemical homeostasis BCL2, CA2, CA7, ESR1, GPR35, HTR2A, HTR2B, HTR2C, PIK3CA, PIK3CB, PRKCB, PRKCE, SMAD3 3.79844
[BP] GO:0051240 positive regulation of multicellular organismal process AXL, BCL2, CA2, CNR1, CYP1B1, EGFR, HSPA1A, HTR2A, HTR2B, KDR, MET, MMP9, PIM1, PRKCA, PRKCB, PRKCE, PTGS2, SMAD3, SRC, TEK 3.78417
[BP] GO:0010511 None HTR2A, HTR2B, HTR2C 3.76066
[BP] GO:0071248 cellular response to metal ion ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 3.74994
[BP] GO:0010632 regulation of epithelial cell migration KDR, MET, MMP9, PRKCA, PRKCE, PTGS2, SRC, TEK 3.71074
[BP] GO:0031324 negative regulation of cellular metabolic process AURKB, BCL2, CNR1, CSNK2A1, DUSP3, ESR1, FABP4, HSPA1A, HTR1B, HTR1E, HTR2B, IGF1R, MET, MMP9, PIK3CA, PPARA, PPARD, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, SMAD3, SRC, TNKS, TNKS2, XDH 3.69699
[BP] GO:0007166 cell surface receptor signaling pathway ADORA3, AXL, BCL2, CSNK2A1, EGFR, FLT3, GPR35, IGF1R, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, SMAD3, SRC, TEK, TNKS, TNKS2 3.69699
[BP] GO:0051128 regulation of cellular component organization ALOX15, AURKB, AXL, BCL2, CNR1, CSNK2A1, EGFR, ESR1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, PIK3CB, PPARD, PRKCD, PRKCE, PRKCG, SMAD3, SRC, TEK, TNKS, TNKS2 3.68915
[BP] GO:0007268 None HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, PRKCG 3.68915
[BP] GO:0098916 None HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, PRKCG 3.68915
[BP] GO:0030003 cellular cation homeostasis BCL2, CA2, CA7, ESR1, GPR35, HTR2A, HTR2B, HTR2C, PIK3CB, PRKCB, PRKCE, SMAD3 3.68514
[BP] GO:0031329 regulation of cellular catabolic process BCL2, CNR1, HSPA1A, HTR2A, HTR2B, INSR, KDR, MET, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCG 3.68514
[BP] GO:0006464 cellular protein modification process ALPL, AURKB, AXL, BCL2, CSNK2A1, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, HTR2B, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SMAD3, SRC, TEK, TNKS, TNKS2, TOP1 3.68514
[BP] GO:0036211 protein modification process ALPL, AURKB, AXL, BCL2, CSNK2A1, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, HTR2B, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SMAD3, SRC, TEK, TNKS, TNKS2, TOP1 3.68514
[BP] GO:0002237 response to molecule of bacterial origin ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, PPARD, PTGS2, SRC 3.65439
[BP] GO:0006874 cellular calcium ion homeostasis BCL2, ESR1, GPR35, HTR2A, HTR2B, HTR2C, PIK3CB, PRKCB, PRKCE, SMAD3 3.64978
[BP] GO:0007188 None CNR1, HTR1A, HTR1B, HTR1D, HTR1E, HTR5A, HTR7 3.62966
[BP] GO:1903530 regulation of secretion by cell ACHE, CNR1, CYP19A1, EGFR, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, PPARD, PRKCA, PRKCE, SRC 3.62966
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, EGFR, ESR1, FLT3, HTR1B, IGF1R, INSR, MMP2, PRKCD, PRKCE, PTGS2, SMAD3, SRC 3.62417
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, HTR2A, MET, SRC 3.61923
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, HTR2A, MET, SRC 3.61923
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, HTR2A, MET, SRC 3.61923
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, HTR2A, MET, SRC 3.61923
[BP] GO:0032787 None ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, PPARA, PPARD, PTGS1, PTGS2 3.61563
[BP] GO:0071704 organic substance metabolic process ACHE, AKR1B1, ALOX15, ALOX5, ALPL, AURKB, AXL, BCL2, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, F10, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD11B2, HSD17B2, HSPA1A, HTR1A, HTR1B, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PPARD, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, SMAD3, SRC, TEK, TNKS, TNKS2, TOP1, TYR, XDH 3.61563
[BP] GO:0006873 cellular ion homeostasis BCL2, CA2, CA7, ESR1, GPR35, HTR2A, HTR2B, HTR2C, PIK3CB, PRKCB, PRKCE, SMAD3 3.60769
[BP] GO:0051052 regulation of DNA metabolic process AURKB, EGFR, IGF1R, INSR, PIK3CA, PRKCD, PRKCG, SRC, TNKS, TNKS2 3.59979
[BP] GO:0001952 regulation of cell-matrix adhesion BCL2, KDR, PIK3CB, SMAD3, SRC, TEK 3.57956
[BP] GO:0044093 positive regulation of molecular function AURKB, BCL2, EGFR, ESR1, FLT3, HSPA1A, HTR2A, HTR2B, INSR, MET, MMP9, PIK3CA, PIK3CB, PRKCB, PRKCD, PRKCE, SMAD3, SRC, TEK, TNKS, XDH 3.57488
[BP] GO:0044089 positive regulation of cellular component biogenesis ALOX15, ESR1, HSPA1A, KDR, MET, MMP1, PRKCA, PRKCE, SMAD3, SRC, TEK 3.56667
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic CNR1, EGFR, HTR1B, HTR2A, PTGS2 3.55892
[BP] GO:0055074 calcium ion homeostasis BCL2, ESR1, GPR35, HTR2A, HTR2B, HTR2C, PIK3CB, PRKCB, PRKCE, SMAD3 3.55892
[BP] GO:0080090 regulation of primary metabolic process ADORA3, ALOX15, AURKB, BCL2, CA9, CNR1, CSNK2A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, FABP3, FABP4, FLT3, HSPA1A, HTR1A, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PPARD, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 3.54823
[BP] GO:0072503 cellular divalent inorganic cation homeostasis BCL2, ESR1, GPR35, HTR2A, HTR2B, HTR2C, PIK3CB, PRKCB, PRKCE, SMAD3 3.51315
[BP] GO:0016572 histone phosphorylation AURKB, PRKCA, PRKCB, PRKCD 3.49368
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B2 3.49368
[BP] GO:0048015 phosphatidylinositol-mediated signaling HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB 3.49368
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, BCL2, CYP1B1, PRKCD, SRC 3.47649
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B2 3.47649
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA3, ALOX15, AURKB, BCL2, CA9, CNR1, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, FABP3, FABP4, FLT3, HSPA1A, HTR1A, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PPARD, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 3.47026
[BP] GO:0031667 response to nutrient levels ALPL, BCL2, CNR1, CYP1A1, EGFR, HSD11B2, PPARD, PTGS2, SRC, TYR 3.4559
[BP] GO:0010038 response to metal ion ALOX15, BCL2, CA2, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 3.43533
[BP] GO:0044238 primary metabolic process ACHE, AKR1B1, ALOX15, ALOX5, ALPL, AURKB, AXL, BCL2, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, F10, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD11B2, HSD17B2, HSPA1A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PPARD, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, SMAD3, SRC, TEK, TNKS, TNKS2, TOP1, TYR, XDH 3.42026
[BP] GO:0031348 negative regulation of defense response CNR2, CYP19A1, PPARA, PPARD, PRKCD, SMAD3, TEK 3.40806
[BP] GO:0001101 response to acid chemical AKR1B1, EGFR, FABP3, HSD17B2, KDR, MMP2, PRKCE, PTGS2, SRC 3.40648
[BP] GO:0048732 gland development BCL2, CSNK2A1, CYP19A1, EGFR, INSR, PIK3CA, SMAD3, TYR 3.40606
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, CNR2, HTR1B, HTR2A, PTGS2 3.40606
[BP] GO:0048017 inositol lipid-mediated signaling HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB 3.40606
[BP] GO:0071241 cellular response to inorganic substance ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 3.39801
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, DUSP3, ESR1, HSPA1A, IGF1R, MET, MMP9, PRKCD, PTGS2, SRC, XDH 3.33994
[BP] GO:0051046 None ACHE, CNR1, CYP19A1, EGFR, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, PPARD, PRKCA, PRKCE, SRC 3.33502
[BP] GO:0050789 regulation of biological process ACHE, ADORA3, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CA9, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, F10, FABP3, FABP4, FLT3, GPR35, HSPA1A, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KCNA3, KDR, MET, MMP1, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PPARD, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, SMAD3, SRC, TEK, TNKS, TNKS2, TOP1, XDH 3.31635
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.31635
[BP] GO:0051246 regulation of protein metabolic process ALOX15, BCL2, CSNK2A1, DUSP3, EGFR, ESR1, FABP4, FLT3, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, SMAD3, SRC, TEK, XDH 3.30905
[BP] GO:0006928 movement of cell or subcellular component AXL, CNR2, CYP1B1, EGFR, FUT7, HTR2B, HTR6, KDR, MMP1, MMP9, PIK3CA, PIK3CB, PPARD, PRKCA, PRKCD, PTGS2, SRC, TEK 3.30012
[BP] GO:0002682 regulation of immune system process ALOX15, AXL, BCL2, CA2, CNR1, CNR2, CYP19A1, DUSP3, ESR1, HSPA1A, MMP2, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, SMAD3, SRC 3.29507
[BP] GO:0045913 None HTR2A, INSR, PPARA, PRKCE, SRC 3.28735
[BP] GO:0001525 angiogenesis CYP1B1, KDR, MMP2, PIK3CA, PIK3CB, PRKCA, PTGS2, TEK 3.24209
[BP] GO:0007154 None AXL, BCL2, CNR1, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, PRKCG, PTGS2, TEK 3.24209
[BP] GO:0097237 cellular response to toxic substance AKR1B1, AXL, CYP1B1, KDR, PRKCD, PRKCE 3.24114
[BP] GO:0010863 positive regulation of phospholipase C activity EGFR, ESR1, HTR2A, HTR2B 3.23436
[BP] GO:0051094 positive regulation of developmental process AXL, BCL2, CA2, CNR1, CYP1B1, HTR2A, HTR2C, INSR, KDR, PIM1, PPARD, PRKCA, PRKCB, PTGS2, SMAD3, SRC, TEK 3.22693
[BP] GO:0051098 regulation of binding AURKB, BCL2, MET, MMP9, PPARA, PRKCD, SMAD3, SRC, TNKS 3.2092
[BP] GO:0019371 None CBR1, PTGS1, PTGS2 3.19455
[BP] GO:0048010 vascular endothelial growth factor receptor signaling pathway AXL, KDR, PIK3CA, PIK3CB, SRC 3.17758
[BP] GO:0043085 positive regulation of catalytic activity AURKB, BCL2, EGFR, ESR1, FLT3, HSPA1A, HTR2A, HTR2B, INSR, PIK3CA, PIK3CB, PRKCD, PRKCE, SMAD3, SRC, TEK, TNKS, XDH 3.15535
[BP] GO:0055065 metal ion homeostasis BCL2, EGFR, ESR1, GPR35, HTR2A, HTR2B, HTR2C, PIK3CB, PRKCB, PRKCE, SMAD3 3.14887
[BP] GO:0051338 regulation of transferase activity AURKB, DUSP3, EGFR, FABP4, FLT3, HTR2A, HTR2B, IGF1R, INSR, PIK3CA, PIK3CB, PRKCD, SRC, TEK, TNKS 3.14354
[BP] GO:0007584 response to nutrient ALPL, CNR1, CYP1A1, EGFR, PPARD, PTGS2, TYR 3.10033
[BP] GO:1900274 regulation of phospholipase C activity EGFR, ESR1, HTR2A, HTR2B 3.09502
[BP] GO:0045759 None CNR1, CNR2, GPR35 3.08318
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA3, ALOX15, AURKB, BCL2, CA9, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, FABP3, FABP4, FLT3, HSPA1A, HTR1A, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PPARD, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 3.08275
[BP] GO:0046456 icosanoid biosynthetic process ALOX15, ALOX5, PTGS1, PTGS2 3.05152
[BP] GO:0042060 None ALOX15, EGFR, PPARA, PPARD, SMAD3 3.04797
[BP] GO:0019725 cellular homeostasis BCL2, CA2, CA7, ESR1, GPR35, HTR2A, HTR2B, HTR2C, PIK3CA, PIK3CB, PRKCB, PRKCE, SMAD3 3.04742
[BP] GO:0043412 macromolecule modification ALPL, AURKB, AXL, BCL2, CSNK2A1, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, HTR2B, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SMAD3, SRC, TEK, TNKS, TNKS2, TOP1 3.042
[BP] GO:0007208 None HTR2A, HTR2C 3.02229
[BP] GO:0035408 None PRKCA, PRKCB 3.02229
[BP] GO:0043434 None FABP3, HSD11B2, INSR, PPARA, PRKCD, PTGS2, SRC, TEK 3.01761
[BP] GO:0007566 embryo implantation MMP2, MMP9, PPARD, PTGS2 3.01761
[BP] GO:0032103 positive regulation of response to external stimulus CNR1, EGFR, FABP4, KDR, MET, PRKCA, PTGS2, SMAD3 3.00844
[BP] GO:0050794 regulation of cellular process ACHE, ADORA3, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CA9, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, F10, FABP3, FABP4, FLT3, GPR35, HSPA1A, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PPARD, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 3.004
[BP] GO:0032230 positive regulation of synaptic transmission, GABAergic CA2, CA7, PRKCE 2.98949
[BP] GO:0002009 morphogenesis of an epithelium BCL2, CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC 2.9785
[BP] GO:0038128 None EGFR, PIK3CA, PRKCA, SRC 2.97776
[BP] GO:0051347 positive regulation of transferase activity AURKB, EGFR, FLT3, HTR2A, HTR2B, INSR, PIK3CA, PIK3CB, PRKCD, SRC, TEK, TNKS 2.97113
[BP] GO:0043393 regulation of protein binding AURKB, BCL2, MET, MMP9, PPARA, PRKCD, SRC 2.9593
[BP] GO:0051384 response to glucocorticoid ALPL, BCL2, EGFR, FLT3, HSD11B2, PTGS2 2.92247
[BP] GO:0090087 None ACHE, CA2, CNR1, EGFR, HTR2B, HTR2C, PPARD, PRKCA, PRKCD, PRKCE, PTGS2, SMAD3, SRC 2.9223
[BP] GO:0050793 regulation of developmental process AXL, BCL2, CA2, CNR1, CYP1B1, EGFR, ESR1, HTR2A, HTR2C, INSR, KDR, NUAK1, PIK3CA, PIM1, PPARA, PPARD, PRKCA, PRKCB, PTGS2, SMAD3, SRC, TEK, TNKS2, XDH 2.91682
[BP] GO:1904407 positive regulation of nitric oxide metabolic process EGFR, INSR, PTGS2, SMAD3 2.90035
[BP] GO:0045429 positive regulation of nitric oxide biosynthetic process EGFR, INSR, PTGS2, SMAD3 2.90035
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.89974
[BP] GO:0022414 reproductive process AKR1B1, ALPL, AXL, BCL2, CNR1, CYP19A1, CYP1A1, EGFR, ESR1, HSD11B2, HSD17B2, INSR, MMP2, MMP9, PPARD, PTGS2, SRC 2.87296
[BP] GO:0010595 positive regulation of endothelial cell migration KDR, MET, PRKCA, PTGS2, TEK 2.8723
[BP] GO:0006875 cellular metal ion homeostasis BCL2, ESR1, GPR35, HTR2A, HTR2B, HTR2C, PIK3CB, PRKCB, PRKCE, SMAD3 2.86019
[BP] GO:0009410 None CNR1, CNR2, EGFR, HTR1B, PRKCE, PRKCG 2.81419
[BP] GO:0003006 developmental process involved in reproduction ALPL, AXL, BCL2, CYP19A1, EGFR, ESR1, HSD17B2, INSR, PPARD, PTGS2, SRC 2.8104
[BP] GO:0051050 positive regulation of transport ACHE, AXL, BCL2, CA2, CYP19A1, EGFR, HTR2B, INSR, PPARD, PRKCD, PRKCE, PTGS2, SMAD3, SRC 2.80233
[BP] GO:0050999 None CNR1, CNR2, EGFR, HTR2B 2.78931
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, EGFR, HTR1B, IGF1R, INSR, MMP2, PRKCD, PTGS2, SRC 2.78503
[BP] GO:0051051 negative regulation of transport BCL2, CNR1, GPR35, HSPA1A, HTR1B, HTR2A, MMP9, PRKCB, PRKCE, PTGS2 2.78503
[BP] GO:0008217 None CNR1, HSD11B2, PPARA, PTGS1, PTGS2, SMAD3 2.77211
[BP] GO:0051209 None HTR2A, HTR2B, HTR2C, PRKCE 2.75782
[BP] GO:0051283 None HTR2A, HTR2B, HTR2C, PRKCE 2.75782
[BP] GO:0043549 regulation of kinase activity DUSP3, EGFR, FABP4, FLT3, HTR2A, HTR2B, IGF1R, INSR, PIK3CA, PIK3CB, PRKCD, SRC, TEK 2.74535
[BP] GO:0071900 regulation of protein serine/threonine kinase activity DUSP3, EGFR, FLT3, HTR2A, HTR2B, IGF1R, INSR, PIK3CB, PRKCD, SRC 2.74102
[BP] GO:2000811 negative regulation of anoikis BCL2, PIK3CA, SRC 2.73925
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.73925
[BP] GO:0019372 lipoxygenase pathway ALOX15, ALOX5, PTGS2 2.73925
[BP] GO:0031334 positive regulation of protein complex assembly ALOX15, ESR1, HSPA1A, MET, MMP1, PRKCE, SRC 2.73329
[BP] GO:0009987 cellular process ACHE, ADORA3, AKR1B1, ALOX15, ALOX5, ALPL, AURKB, AXL, BCL2, CA12, CA2, CA4, CA7, CA9, CBR1, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, F10, FABP3, FABP4, FLT3, FUT7, GPR35, HSD17B2, HSPA1A, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KCNA3, KDR, MET, MMP1, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PPARD, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, SMAD3, SRC, TEK, TNKS, TNKS2, TOP1, TYR, XDH 2.72581
[BP] GO:0046486 glycerolipid metabolic process ACHE, ALOX15, CSNK2A1, EGFR, FABP3, FABP4, MET, PIK3CA, PIK3CB 2.72286
[BP] GO:0045766 positive regulation of angiogenesis CYP1B1, KDR, PRKCA, PRKCB, PTGS2, TEK 2.7055
[BP] GO:0019752 carboxylic acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, PIM1, PPARA, PPARD, PTGS1, PTGS2, TYR 2.70243
[BP] GO:0007568 aging AURKB, BCL2, CNR1, CYP1A1, HTR2A, PRKCD, PTGS2 2.66878
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, HSPA1A, MMP9, PTGS2, SRC 2.66878
[BP] GO:1904951 positive regulation of establishment of protein localization ACHE, BCL2, EGFR, HTR2B, PPARD, PRKCD, PRKCE, PTGS2, SMAD3, SRC 2.66878
[BP] GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress BCL2, CYP1B1, PRKCD 2.66878
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.66878
[BP] GO:0007267 None CNR1, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, PRKCG, TEK 2.66612
[BP] GO:0006939 None HTR1D, HTR2A, HTR2B, HTR7 2.66589
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, ALOX15, BCL2, CYP19A1, CYP1A1, CYP1B1, HTR1A, PPARD, TYR 2.65289
[BP] GO:0010518 positive regulation of phospholipase activity EGFR, ESR1, HTR2A, HTR2B 2.63269
[BP] GO:0014066 regulation of phosphatidylinositol 3-kinase signaling EGFR, FLT3, KDR, PPARD, TEK 2.63269
[BP] GO:0031349 positive regulation of defense response CNR1, EGFR, FABP4, HSPA1A, MMP2, PRKCD, PRKCE, PTGS2, SRC 2.62465
[BP] GO:0015711 organic anion transport CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, PPARD 2.62465
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.61377
[BP] GO:0019637 organophosphate metabolic process ACHE, ALOX15, CSNK2A1, EGFR, HSPA1A, HTR2B, HTR2C, MET, PIK3CA, PIK3CB, PPARD, PTGS2, XDH 2.57407
[BP] GO:0050678 None EGFR, HTR2B, KDR, PPARD, PRKCA, SMAD3, TEK, XDH 2.55579
[BP] GO:0050776 regulation of immune response ALOX15, BCL2, CNR1, DUSP3, ESR1, HSPA1A, MMP2, PIK3CA, PIK3CB, PRKCB, PRKCD, PRKCE, SMAD3, SRC 2.55346
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, EGFR, HTR1B, IGF1R, INSR, MMP2, PRKCD, PTGS2, SRC 2.55346
[BP] GO:1903428 positive regulation of reactive oxygen species biosynthetic process EGFR, INSR, PTGS2, SMAD3 2.54393
[BP] GO:0010676 None INSR, PPARA, PRKCE, SRC 2.54393
[BP] GO:0050994 None CNR1, PPARA, PRKCD, PRKCE 2.54393
[BP] GO:0072593 reactive oxygen species metabolic process BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR 2.54218
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.5386
[BP] GO:0046890 None FABP3, HTR2A, HTR2B, HTR2C, PRKCD, PTGS2 2.5386
[BP] GO:0051726 regulation of cell cycle AURKB, BCL2, CSNK2A1, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, PIM1, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TNKS 2.5386
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.51611
[BP] GO:0071456 cellular response to hypoxia BCL2, PPARD, PRKCE, PTGS2, SRC 2.50682
[BP] GO:0007346 regulation of mitotic cell cycle AURKB, BCL2, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, PIM1, PRKCA, SMAD3, TNKS 2.48952
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.48889
[BP] GO:0033555 multicellular organismal response to stress BCL2, HTR1A, HTR2C, PRKCG 2.48889
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.48889
[BP] GO:0033674 positive regulation of kinase activity EGFR, FLT3, HTR2A, HTR2B, INSR, PIK3CA, PIK3CB, PRKCD, SRC, TEK 2.47366
[BP] GO:0010811 positive regulation of cell-substrate adhesion ALOX15, KDR, PRKCE, SMAD3, TEK 2.4732
[BP] GO:0032768 None CNR1, CNR2, EGFR, HTR2B 2.46032
[BP] GO:0006721 terpenoid metabolic process CYP1A1, CYP1A2, CYP1B1, EGFR, PPARD 2.45571
[BP] GO:0045859 regulation of protein kinase activity DUSP3, EGFR, FABP4, FLT3, HTR2A, HTR2B, IGF1R, INSR, PIK3CA, PIK3CB, PRKCD, SRC 2.44873
[BP] GO:0009896 positive regulation of catabolic process CSNK2A1, HSPA1A, HTR2A, INSR, KDR, PIK3CB, PPARA, PRKCD, PRKCE 2.44225
[BP] GO:1904018 positive regulation of vasculature development CYP1B1, KDR, PRKCA, PRKCB, PTGS2, TEK 2.44031
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, EGFR, HTR1A, INSR, PTGS2, SMAD3 2.43801
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.42106
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.42106
[BP] GO:0009891 positive regulation of biosynthetic process AURKB, EGFR, ESR1, FABP3, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, PPARA, PPARD, PRKCD, PTGS2, SMAD3, SRC, TNKS, TNKS2 2.41322
[BP] GO:0097553 None HTR2A, HTR2B, HTR2C, PRKCE 2.41153
[BP] GO:0072347 None CNR1, HTR1B, PRKCE, PRKCG 2.41153
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.41153
[BP] GO:0045428 regulation of nitric oxide biosynthetic process EGFR, INSR, PTGS2, SMAD3 2.41153
[BP] GO:1901654 None AKR1B1, CA9, CSNK2A1, EGFR, PRKCE, SRC 2.40805
[BP] GO:0002791 None ACHE, CNR1, EGFR, HTR2B, HTR2C, PPARD, PRKCA, PRKCE, SRC 2.40241
[BP] GO:0050900 leukocyte migration CNR2, FUT7, MMP1, MMP9, PIK3CA, PIK3CB, SRC, TEK 2.40241
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, CYP1A1, CYP1B1, EGFR, ESR1, FLT3, PTGS2, SRC 2.40241
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, ADORA3, ALOX15, AURKB, BCL2, CA9, CSNK2A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, FABP4, FLT3, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PPARD, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, SMAD3, SRC, TEK, TNKS, TNKS2, TOP1, XDH 2.40061
[BP] GO:0036294 cellular response to decreased oxygen levels BCL2, PPARD, PRKCE, PTGS2, SRC 2.39692
[BP] GO:0033043 regulation of organelle organization ALOX15, AURKB, BCL2, HSPA1A, INSR, KDR, MET, MMP9, PRKCD, PRKCE, SMAD3, SRC, TEK, TNKS, TNKS2 2.39324
[BP] GO:0009888 tissue development ALOX15, ALPL, CYP1B1, INSR, KDR, PIK3CA, PPARA, PPARD, PTGS2, SMAD3 2.37914
[BP] GO:0048729 tissue morphogenesis BCL2, CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC 2.37353
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation HTR1B, MMP2, MMP9 2.37353
[BP] GO:0050996 None PPARA, PRKCD, PRKCE 2.37353
[BP] GO:0043207 response to external biotic stimulus ALPL, AXL, BCL2, CNR1, CNR2, CYP1A1, CYP1A2, PPARD, PRKCD, PTGS2, SMAD3, SRC 2.37228
[BP] GO:0045600 positive regulation of fat cell differentiation HTR2A, HTR2C, PPARD, PTGS2 2.36648
[BP] GO:0034502 protein localization to chromosome AURKB, ESR1, TNKS, TNKS2 2.36648
[BP] GO:0010517 regulation of phospholipase activity EGFR, ESR1, HTR2A, HTR2B 2.36648
[BP] GO:0043406 positive regulation of MAP kinase activity EGFR, FLT3, HTR2A, HTR2B, INSR, PIK3CB, SRC 2.36521
[BP] GO:0070213 None TNKS, TNKS2 2.36424
[BP] GO:0038171 None CNR1, CNR2 2.36424
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.36424
[BP] GO:0014827 None HTR1D, HTR2B 2.36424
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, NQO2, PTGS1 2.35568
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.34504
[BP] GO:0043436 oxoacid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, PIM1, PPARA, PPARD, PTGS1, PTGS2, TYR 2.33628
[BP] GO:2000209 regulation of anoikis BCL2, PIK3CA, SRC 2.32849
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.32849
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, AXL, CYP1B1, PRKCD 2.32135
[BP] GO:0048608 reproductive structure development AXL, BCL2, CYP19A1, ESR1, HSD17B2, INSR, SRC 2.31609
[BP] GO:0023052 None CNR1, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, PRKCG, TEK 2.31331
[BP] GO:0051172 None AURKB, CSNK2A1, DUSP3, EGFR, ESR1, FABP4, HSPA1A, HTR1B, HTR1E, IGF1R, MMP9, PPARA, PPARD, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, SMAD3, SRC, TNKS, TNKS2, XDH 2.3133
[BP] GO:0070201 None ACHE, BCL2, CNR1, EGFR, HTR2B, PPARD, PRKCA, PRKCD, PRKCE, PTGS2, SMAD3, SRC 2.30993
[BP] GO:0060193 positive regulation of lipase activity EGFR, ESR1, HTR2A, HTR2B 2.2981
[BP] GO:0051894 None KDR, SMAD3, TEK 2.28225
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B2 2.28225
[BP] GO:0007202 None EGFR, HTR2A, HTR2B 2.28225
[BP] GO:0032098 None HTR2C, HTR4, PPARA 2.28225
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.28225
[BP] GO:0006082 organic acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, PIM1, PPARA, PPARD, PTGS1, PTGS2, TYR 2.27249
[BP] GO:0045787 positive regulation of cell cycle AURKB, CYP1A1, DUSP3, EGFR, INSR, PRKCA, PRKCE, SRC 2.26908
[BP] GO:0045598 None HTR2A, HTR2C, PPARD, PTGS2, SMAD3 2.26893
[BP] GO:0009605 response to external stimulus ALPL, AXL, BCL2, CNR1, CNR2, CYP1A1, CYP1A2, EGFR, HSD11B2, HTR2A, PPARD, PRKCD, PTGS2, SMAD3, SRC, TYR 2.25539
[BP] GO:2000573 positive regulation of DNA biosynthetic process AURKB, SRC, TNKS, TNKS2 2.25539
[BP] GO:0060402 None HTR2A, HTR2B, HTR2C, PRKCE 2.25539
[BP] GO:0050806 positive regulation of synaptic transmission CA2, CA7, EGFR, PRKCE, PTGS2 2.25539
[BP] GO:0032102 negative regulation of response to external stimulus CNR2, CYP19A1, PPARA, PPARD, PRKCD, SMAD3, TEK 2.24344
[BP] GO:0051222 positive regulation of protein transport ACHE, EGFR, HTR2B, PPARD, PRKCD, PRKCE, PTGS2, SMAD3, SRC 2.23832
[BP] GO:0051495 positive regulation of cytoskeleton organization ALOX15, HSPA1A, MET, PRKCE, SMAD3, TEK 2.2333
[BP] GO:0009607 response to biotic stimulus ALPL, AXL, BCL2, CNR1, CNR2, CYP1A1, CYP1A2, PPARD, PRKCD, PTGS2, SMAD3, SRC 2.23273
[BP] GO:0032355 response to estradiol CYP1A2, EGFR, ESR1, HTR5A, PTGS2 2.20964
[BP] GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling FLT3, KDR, PPARD, TEK 2.20929
[BP] GO:0006720 isoprenoid metabolic process CYP1A1, CYP1A2, CYP1B1, EGFR, PPARD 2.19579
[BP] GO:0007155 cell adhesion ACHE, AXL, BCL2, CYP1B1, EGFR, NUAK1, PIK3CB, PPARD, PRKCA, PRKCE, SRC, TEK 2.19401
[BP] GO:0051480 regulation of cytosolic calcium ion concentration ESR1, GPR35, HTR2A, HTR2B, HTR2C, PRKCE, SMAD3 2.19401
[BP] GO:1904353 regulation of telomere capping AURKB, TNKS, TNKS2 2.19294
[BP] GO:1903393 None KDR, SMAD3, TEK 2.19294
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B2 2.1854
[BP] GO:0071502 None HTR1B, HTR2B 2.1805
[BP] GO:0043065 positive regulation of apoptotic process BCL2, CNR1, CYP1B1, MMP9, PIK3CB, PRKCD, PTGS2, SMAD3, SRC, XDH 2.17394
[BP] GO:0022610 biological adhesion ACHE, AXL, BCL2, CYP1B1, EGFR, NUAK1, PIK3CB, PPARD, PRKCA, PRKCE, SRC, TEK 2.17394
[BP] GO:0071453 cellular response to oxygen levels BCL2, PPARD, PRKCE, PTGS2, SRC 2.17343
[BP] GO:0090407 organophosphate biosynthetic process ACHE, ALOX15, CSNK2A1, HTR2B, HTR2C, PIK3CA, PIK3CB, PPARD, PTGS2 2.16731
[BP] GO:0045785 positive regulation of cell adhesion ALOX15, KDR, PIK3CA, PRKCA, PRKCE, SMAD3, SRC, TEK 2.16651
[BP] GO:0090276 None CNR1, EGFR, HTR2C, PPARD, PRKCA, PRKCE 2.16651
[BP] GO:1904357 None SRC, TNKS, TNKS2 2.15452
[BP] GO:0043068 positive regulation of programmed cell death BCL2, CNR1, CYP1B1, MMP9, PIK3CB, PRKCD, PTGS2, SMAD3, SRC, XDH 2.148
[BP] GO:1900182 positive regulation of protein localization to nucleus EGFR, PRKCD, PTGS2, SMAD3, SRC 2.13654
[BP] GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis PIK3CA, PIK3CB, PRKCD, PRKCE, SRC 2.13654
[BP] GO:0002433 immune response-regulating cell surface receptor signaling pathway involved in phagocytosis PIK3CA, PIK3CB, PRKCD, PRKCE, SRC 2.13654
[BP] GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process CSNK2A1, MMP9, PTGS2, SMAD3, SRC, XDH 2.12918
[BP] GO:0043254 regulation of protein complex assembly ALOX15, ESR1, HSPA1A, MET, MMP1, PRKCD, PRKCE, SRC 2.12351
[BP] GO:0002684 positive regulation of immune system process AXL, BCL2, CA2, CNR1, HSPA1A, MMP2, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, SRC 2.12047
[BP] GO:0046320 None CNR1, FABP3, PPARA 2.11537
[BP] GO:0014059 None CNR1, HTR1B, HTR2A 2.11537
[BP] GO:1900543 None HTR1B, HTR1E, PPARA, PRKCA 2.11384
[BP] GO:0010507 negative regulation of autophagy BCL2, HTR2B, MET, PIK3CA 2.11384
[BP] GO:0002431 Fc receptor mediated stimulatory signaling pathway PIK3CA, PIK3CB, PRKCD, PRKCE, SRC 2.11273
[BP] GO:0044087 regulation of cellular component biogenesis ALOX15, ESR1, HSPA1A, KDR, MET, MMP1, PRKCA, PRKCD, PRKCE, SMAD3, SRC, TEK 2.10524
[BP] GO:0006811 None CA12, CA14, CA2, CA4, CA7, CA9, FABP3, HTR2A, HTR2B, HTR2C, KCNA3, PPARA, PPARD, PRKCB, PRKCE 2.1048
[BP] GO:0009411 response to UV AURKB, BCL2, EGFR, PTGS2, TYR 2.10058
[BP] GO:0001936 None HTR2B, KDR, PRKCA, TEK, XDH 2.10058
[BP] GO:0045980 None HTR1B, HTR1E, PPARA, PRKCA 2.09505
[BP] GO:0038094 Fc-gamma receptor signaling pathway PIK3CA, PIK3CB, PRKCD, PRKCE, SRC 2.08699
[BP] GO:0031328 positive regulation of cellular biosynthetic process AURKB, EGFR, ESR1, FABP3, HTR2A, HTR2B, HTR2C, IGF1R, INSR, MET, PPARA, PPARD, PRKCD, PTGS2, SMAD3, SRC, TNKS, TNKS2 2.08385
[BP] GO:0044419 interspecies interaction between organisms AXL, EGFR, HSPA1A, HTR2A, INSR, KDR, MET, MMP1, SMAD3, SRC, TOP1 2.08171
[BP] GO:0006636 unsaturated fatty acid biosynthetic process ALOX15, PTGS1, PTGS2 2.08171
[BP] GO:0033280 response to vitamin D ALPL, PTGS2, TYR 2.08171
[BP] GO:0031330 negative regulation of cellular catabolic process BCL2, CNR1, HTR2B, MET, PIK3CA, PRKCG 2.0782
[BP] GO:0001667 ameboidal-type cell migration CYP1B1, HTR2B, KDR, PIK3CA, PPARD 2.07814
[BP] GO:0045860 positive regulation of protein kinase activity EGFR, FLT3, HTR2A, HTR2B, INSR, PIK3CA, PIK3CB, PRKCD, SRC 2.06754
[BP] GO:0031099 regeneration AXL, BCL2, CSNK2A1, EGFR, FLT3 2.06477
[BP] GO:0032880 regulation of protein localization ACHE, BCL2, CNR1, CSNK2A1, EGFR, HTR2B, PPARD, PRKCA, PRKCD, PRKCE, PTGS2, SMAD3, SRC 2.05587
[BP] GO:0035239 tube morphogenesis BCL2, EGFR, ESR1, MET, SMAD3, SRC 2.04988
[BP] GO:0035265 organ growth BCL2, CYP19A1, ESR1 2.04717
[BP] GO:0002209 None BCL2, HTR1A, HTR2C 2.04717
[BP] GO:0001662 None BCL2, HTR1A, HTR2C 2.04717
[BP] GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity FLT3, SRC, TEK 2.04717
[BP] GO:0042743 hydrogen peroxide metabolic process CYP1A1, CYP1A2, EGFR 2.04717
[BP] GO:0051902 negative regulation of mitochondrial depolarization BCL2, SRC 2.04717
[BP] GO:0014831 None HTR1D, HTR2B 2.04717
[BP] GO:0032229 None CNR2, HTR1B 2.04717
[BP] GO:2001300 lipoxin metabolic process ALOX15, ALOX5 2.04717
[BP] GO:0031214 biomineral tissue development ALOX15, ALPL, PPARA, PTGS2 2.04493
[BP] GO:0006644 phospholipid metabolic process ACHE, ALOX15, CSNK2A1, EGFR, MET, PIK3CA, PIK3CB, PPARD 2.04211
[BP] GO:0032868 None FABP3, HSD11B2, INSR, PPARA, SRC 2.03209
[BP] GO:0031100 animal organ regeneration AXL, CSNK2A1, EGFR, FLT3 2.02724
[BP] GO:0060401 None HTR2A, HTR2B, HTR2C, PRKCE 2.02724
[BP] GO:0009968 negative regulation of signal transduction BCL2, DUSP3, EGFR, ESR1, HSPA1A, IGF1R, MET, MMP9, PRKCB, PRKCD, PTGS2, SMAD3, SRC, XDH 2.01851
[BP] GO:1901890 None KDR, SMAD3, TEK 2.01384
[BP] GO:0071276 cellular response to cadmium ion CYP1A2, EGFR, MMP9 2.01384
[BP] GO:0010631 epithelial cell migration CYP1B1, KDR, PIK3CA, PPARD 2.00834
[CC] GO:0005886 plasma membrane ACHE, ADORA3, ALOX15, ALPL, AXL, CA12, CA14, CA2, CA4, CA9, CNR1, CNR2, CSNK2A1, EGFR, ESR1, F10, FLT3, GPR35, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KCNA3, KDR, MET, MMP2, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SMAD3, SRC, TEK 8.57682
[CC] GO:0016020 membrane ACHE, ADORA3, ALOX15, ALOX5, ALPL, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, F10, FLT3, FUT7, GPR35, HSD11B1, HSD11B2, HSD17B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KCNA3, KDR, MET, MMP2, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, SMAD3, SRC, TEK, TNKS, TNKS2, TYR 8.41669
[CC] GO:0044459 plasma membrane part ADORA3, ALOX15, AXL, CA2, CA4, CA9, CNR1, CNR2, DUSP3, EGFR, F10, FLT3, GPR35, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KCNA3, KDR, MET, PRKCG, PTGS2, SRC, TEK 6.79636
[CC] GO:0031226 intrinsic component of plasma membrane ADORA3, AXL, CA4, CNR1, CNR2, F10, FLT3, GPR35, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, TEK 6.45627
[CC] GO:0044425 membrane part ACHE, ADORA3, ALOX15, ALPL, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CNR1, CNR2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, GPR35, HSD11B1, HSD11B2, HSD17B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KCNA3, KDR, MET, MPEG1, PIK3CA, PIK3CB, PRKCG, PTGS1, PTGS2, SRC, TEK, TYR 5.77519
[CC] GO:0005887 integral component of plasma membrane ADORA3, AXL, CNR1, CNR2, FLT3, GPR35, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, TEK 5.51162
[CC] GO:0045121 membrane raft CNR1, EGFR, HTR2A, INSR, KCNA3, KDR, PTGS2, SRC, TEK 3.68458
[CC] GO:0098857 membrane microdomain CNR1, EGFR, HTR2A, INSR, KCNA3, KDR, PTGS2, SRC, TEK 3.66342
[CC] GO:0048471 perinuclear region of cytoplasm ACHE, AKR1B1, CA4, EGFR, HSPA1A, PRKCA, PRKCD, PRKCE, PRKCG, SRC, TNKS2, TYR 3.18959
[CC] GO:0098589 membrane region CNR1, EGFR, HTR2A, INSR, KCNA3, KDR, PTGS2, SRC, TEK 3.10975
[CC] GO:0031224 None ACHE, ADORA3, ALPL, AXL, CA12, CA14, CA4, CA9, CNR1, CNR2, EGFR, ESR1, F10, FLT3, FUT7, GPR35, HSD11B1, HSD17B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KCNA3, KDR, MET, MPEG1, TEK, TYR 2.34076
[CC] GO:0005901 caveola HTR2A, INSR, PTGS2, SRC 2.11384
[MF] GO:0004993 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 16.7127
[MF] GO:0099589 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 16.7127
[MF] GO:0043176 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 16.5793
[MF] GO:0051378 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 16.5793
[MF] GO:0099528 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 14.35
[MF] GO:0043167 ion binding ACHE, ALOX15, ALOX5, ALPL, AURKB, AXL, CA12, CA14, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, F10, FABP3, FABP4, FLT3, HSPA1A, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PPARD, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, SMAD3, SRC, TEK, TNKS, TNKS2, TOP1, TYR, XDH 14.076
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FLT3, HSPA1A, HTR1B, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PPARD, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP1 13.0673
[MF] GO:0008227 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 12.3903
[MF] GO:0042165 neurotransmitter binding ACHE, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 11.1002
[MF] GO:0046914 transition metal ion binding ALOX15, ALOX5, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, MMP1, MMP2, MMP9, NQO2, PIM1, PPARA, PPARD, PRKCA, PRKCB, PRKCG, SMAD3, TNKS, TYR, XDH 10.5455
[MF] GO:0070405 ammonium ion binding ACHE, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 9.67572
[MF] GO:0030594 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 9.43382
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP1 9.28651
[MF] GO:0043169 cation binding ACHE, ALOX15, ALOX5, ALPL, AURKB, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, F10, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, MMP1, MMP2, MMP9, NQO2, NUAK1, PIM1, PPARA, PPARD, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, SMAD3, TNKS, TNKS2, TYR, XDH 9.1716
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP1 8.87513
[MF] GO:0003824 catalytic activity ACHE, AKR1B1, ALOX15, ALOX5, ALPL, AURKB, AXL, CA12, CA14, CA2, CA4, CA7, CA9, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, F10, FLT3, FUT7, HSD11B1, HSD11B2, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, SRC, TEK, TNKS, TNKS2, TOP1, TYR, XDH 8.87513
[MF] GO:0038023 signaling receptor activity ADORA3, AXL, CNR1, CNR2, EGFR, ESR1, FLT3, GPR35, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, PPARA, PPARD, TEK 8.36799
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP1 8.26291
[MF] GO:0004089 carbonate dehydratase activity CA12, CA14, CA2, CA4, CA7, CA9 8.22948
[MF] GO:0004871 signal transducer activity ADORA3, AXL, CNR1, CNR2, EGFR, ESR1, FLT3, GPR35, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, PPARA, PPARD, PRKCE, SMAD3, TEK 7.84768
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 7.38312
[MF] GO:0004872 receptor activity ADORA3, AXL, CNR1, CNR2, EGFR, ESR1, FLT3, GPR35, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, PPARA, PPARD, TEK 7.31183
[MF] GO:0060089 molecular transducer activity ADORA3, AXL, CNR1, CNR2, EGFR, ESR1, FLT3, GPR35, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, PPARA, PPARD, TEK 7.0516
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP1 7.0458
[MF] GO:0043560 insulin receptor substrate binding IGF1R, INSR, PIK3CA, PIK3CB, PRKCD 6.96579
[MF] GO:0099600 transmembrane receptor activity ADORA3, AXL, CNR1, CNR2, EGFR, FLT3, GPR35, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, TEK 6.96362
[MF] GO:0004888 transmembrane signaling receptor activity ADORA3, AXL, CNR1, CNR2, EGFR, FLT3, GPR35, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, TEK 6.96362
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 6.65187
[MF] GO:0004713 protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, PRKCD, SRC, TEK 6.25357
[MF] GO:0004697 None PRKCA, PRKCB, PRKCD, PRKCE, PRKCG 6.15941
[MF] GO:0008270 zinc ion binding CA12, CA2, CA4, CA7, CA9, ESR1, MMP1, MMP2, MMP9, NQO2, PPARA, PPARD, PRKCA, PRKCB, PRKCG, SMAD3, TNKS 5.56106
[MF] GO:0016491 oxidoreductase activity AKR1B1, ALOX15, ALOX5, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B1, HSD11B2, HSD17B2, NQO2, PTGS1, PTGS2, TYR, XDH 5.41773
[MF] GO:0005524 ATP binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP1 5.18019
[MF] GO:0032559 adenyl ribonucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP1 5.02248
[MF] GO:0030554 adenyl nucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP1 4.97921
[MF] GO:0016836 hydro-lyase activity CA12, CA14, CA2, CA4, CA7, CA9 4.97848
[MF] GO:0036094 small molecule binding AURKB, AXL, CSNK2A1, EGFR, FABP3, FABP4, FLT3, HSD11B2, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARD, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP1, XDH 4.86625
[MF] GO:0004698 None PRKCA, PRKCB, PRKCG 4.58382
[MF] GO:0004674 protein serine/threonine kinase activity AURKB, CSNK2A1, EGFR, NUAK1, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, TOP1 4.58192
[MF] GO:0043168 anion binding ALOX15, AURKB, AXL, CSNK2A1, EGFR, F10, FABP3, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARD, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP1, XDH 4.47881
[MF] GO:0000166 nucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSD11B2, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP1, XDH 4.42843
[MF] GO:1901265 nucleoside phosphate binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSD11B2, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP1, XDH 4.42641
[MF] GO:0016835 carbon-oxygen lyase activity CA12, CA14, CA2, CA4, CA7, CA9 4.27682
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, SRC 4.12507
[MF] GO:0046872 metal ion binding ALOX15, ALOX5, ALPL, AURKB, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, F10, MMP1, MMP2, MMP9, NQO2, NUAK1, PIM1, PPARA, PPARD, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, SMAD3, TNKS, TNKS2, TYR, XDH 4.0551
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, SRC 3.93229
[MF] GO:0035639 purine ribonucleoside triphosphate binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP1 3.84687
[MF] GO:0004930 None ADORA3, CNR1, CNR2, GPR35, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 3.83638
[MF] GO:1901363 heterocyclic compound binding AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FLT3, HSD11B2, HSPA1A, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PPARD, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, SMAD3, SRC, TEK, TOP1, XDH 3.83505
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.7854
[MF] GO:0097159 organic cyclic compound binding AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FLT3, HSD11B2, HSPA1A, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PPARD, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, SMAD3, SRC, TEK, TOP1, XDH 3.73899
[MF] GO:0032555 purine ribonucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP1 3.69681
[MF] GO:0017076 purine nucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP1 3.66429
[MF] GO:0032553 ribonucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP1 3.65579
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, TYR 3.64528
[MF] GO:0140096 catalytic activity, acting on a protein AURKB, AXL, CSNK2A1, DUSP3, EGFR, F10, FLT3, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NUAK1, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP1 3.6115
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.6115
[MF] GO:0005506 iron ion binding ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, XDH 3.5754
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR 3.45419
[MF] GO:0009931 None PRKCA, PRKCB, PRKCG 3.19455
[MF] GO:0010857 None PRKCA, PRKCB, PRKCG 3.08318
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 3.02229
[MF] GO:0003845 None HSD11B1, HSD11B2 3.02229
[MF] GO:0035403 None PRKCA, PRKCB 3.02229
[MF] GO:0071886 None HTR2A, HTR2C 3.02229
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, CBR1, HSD11B1, HSD11B2, HSD17B2, XDH 2.97164
[MF] GO:0016740 transferase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, FUT7, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TNKS, TNKS2, TOP1 2.94921
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B2, NQO2, PTGS1, PTGS2, SRC, XDH 2.8723
[MF] GO:0042562 hormone binding ACHE, EGFR, IGF1R, INSR, NQO2 2.8723
[MF] GO:0035258 None ESR1, FLT3, PRKCB, SMAD3, SRC 2.8037
[MF] GO:0097367 carbohydrate derivative binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP1 2.76274
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 2.75782
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, TYR 2.66878
[MF] GO:0035173 histone kinase activity AURKB, PRKCA, PRKCB 2.66878
[MF] GO:0050473 arachidonate 15-lipoxygenase activity ALOX15, PTGS2 2.61377
[MF] GO:0004949 None CNR1, CNR2 2.61377
[MF] GO:0004699 None PRKCD, PRKCE 2.61377
[MF] GO:0009055 electron transfer activity AKR1B1, CYP19A1, CYP1A2, NQO2, XDH 2.44031
[MF] GO:0016829 lyase activity CA12, CA14, CA2, CA4, CA7, CA9 2.34794
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, CBR1, HSD11B1, HSD11B2, HSD17B2 2.28225
[MF] GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity EGFR, MET, PIK3CA, PIK3CB 2.20929
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX15, ALOX5, PTGS2 2.19294
[MF] GO:0044877 macromolecular complex binding ACHE, CSNK2A1, EGFR, FLT3, HTR2A, IGF1R, INSR, KDR, MMP9, PIM1, PPARA, SMAD3, SRC 2.19247
[MF] GO:0043559 insulin binding IGF1R, INSR 2.1805
[MF] GO:0005504 None FABP3, FABP4, PPARD 2.15452
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD11B2, HSD17B2 2.15452
[MF] GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen ALOX15, ALOX5, PTGS2 2.15452
[MF] GO:0052813 phosphatidylinositol bisphosphate kinase activity EGFR, MET, PIK3CA, PIK3CB 2.15156
[MF] GO:0019838 growth factor binding EGFR, IGF1R, INSR, KDR, TEK 2.13654
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD11B2, HSD17B2 2.08171
[MF] GO:0043548 phosphatidylinositol 3-kinase binding AXL, IGF1R, INSR 2.08171
[MF] GO:0035004 phosphatidylinositol 3-kinase activity EGFR, MET, PIK3CA, PIK3CB 2.05835
[MF] GO:0104005 hijacked molecular function AXL, EGFR, HSPA1A, HTR2A 2.02724
[MF] GO:0001618 virus receptor activity AXL, EGFR, HSPA1A, HTR2A 2.02724


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Serotonergic synapse_Homo sapiens_hsa04726 PRKCG, HTR1E, PRKCB, ALOX15, HTR1D, HTR2B, HTR1A, HTR1B, HTR2C, PRKCA, HTR2A, PTGS2, HTR5A, HTR4, PTGS1, HTR6, HTR7, ALOX5 21.7251
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 PRKCG, PIK3CA, PRKCB, SRC, PRKCE, PRKCD, HTR2B, HTR2C, PRKCA, PIK3CB, HTR2A 10.9987
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 HTR1E, GPR35, HTR1D, HTR2B, HTR1A, HTR1B, HTR2C, HTR2A, HTR5A, HTR4, HTR6, HTR7, CNR2, CNR1, ADORA3 10.9987
Proteoglycans in cancer_Homo sapiens_hsa05205 PRKCG, PRKCB, SRC, MMP2, PRKCA, PIK3CB, MMP9, ESR1, EGFR, IGF1R, PIK3CA, KDR, MET 10.3735
Pathways in cancer_Homo sapiens_hsa05200 PRKCG, SMAD3, PRKCB, FLT3, MMP1, MMP2, PRKCA, PIK3CB, PTGS2, MMP9, EGFR, IGF1R, PIK3CA, BCL2, MET, PPARD 10.1761
Rap1 signaling pathway_Homo sapiens_hsa04015 PRKCG, PRKCB, SRC, INSR, PRKCA, PIK3CB, EGFR, IGF1R, PIK3CA, CNR1, KDR, TEK, MET 10.2562
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, PIK3CA, PRKCB, MMP2, PRKCE, PRKCD, BCL2, PIM1, PRKCA, PIK3CB 9.8136
HIF-1 signaling pathway_Homo sapiens_hsa04066 PRKCG, PIK3CA, PRKCB, INSR, BCL2, PRKCA, TEK, PIK3CB, EGFR, IGF1R 9.7852
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 9.4931
Ras signaling pathway_Homo sapiens_hsa04014 PRKCG, HTR7, PIK3CA, PRKCB, INSR, KDR, PRKCA, TEK, PIK3CB, MET, EGFR, IGF1R 8.9363
Calcium signaling pathway_Homo sapiens_hsa04020 PRKCG, HTR6, HTR7, PRKCB, HTR2B, HTR2C, PRKCA, HTR2A, HTR5A, HTR4, EGFR 8.8668
VEGF signaling pathway_Homo sapiens_hsa04370 PRKCG, PIK3CA, PRKCB, SRC, KDR, PRKCA, PIK3CB, PTGS2 8.8938
Estrogen signaling pathway_Homo sapiens_hsa04915 PIK3CA, SRC, MMP2, PRKCD, PIK3CB, MMP9, ESR1, EGFR, HSPA1A 8.7272
Focal adhesion_Homo sapiens_hsa04510 PRKCG, PIK3CA, PRKCB, SRC, KDR, BCL2, PRKCA, PIK3CB, MET, EGFR, IGF1R 8.4206
MicroRNAs in cancer_Homo sapiens_hsa05206 PRKCG, PIK3CA, PRKCB, PRKCE, BCL2, PIM1, CYP1B1, PRKCA, PTGS2, MMP9, MET, EGFR 7.7875
Hepatitis B_Homo sapiens_hsa05161 PRKCG, SMAD3, PIK3CA, PRKCB, SRC, BCL2, PRKCA, PIK3CB, MMP9 7.3438
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 PRKCG, HSD11B2, PIK3CA, PRKCB, INSR, PRKCA, PIK3CB 8.7647
Gap junction_Homo sapiens_hsa04540 PRKCG, PRKCB, SRC, HTR2B, HTR2C, PRKCA, HTR2A, EGFR 7.7675
Glioma_Homo sapiens_hsa05214 PRKCG, PIK3CA, PRKCB, PRKCA, PIK3CB, EGFR, IGF1R 7.3202
Sphingolipid signaling pathway_Homo sapiens_hsa04071 PRKCG, PIK3CA, PRKCB, ADORA3, PRKCE, BCL2, PRKCA, PIK3CB 6.8008
cAMP signaling pathway_Homo sapiens_hsa04024 HTR6, PIK3CA, HTR1E, HTR1D, HTR1A, HTR1B, PIK3CB, PPARA, HTR4 6.3215
Adherens junction_Homo sapiens_hsa04520 SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R 6.9401
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 7.6319
ErbB signaling pathway_Homo sapiens_hsa04012 PRKCG, PIK3CA, PRKCB, SRC, PRKCA, PIK3CB, EGFR 6.484
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PRKCG, PIK3CA, PRKCB, PRKCE, PRKCD, PRKCA, PIK3CB 6.3215
Oxytocin signaling pathway_Homo sapiens_hsa04921 PRKCG, PIK3CA, PRKCB, SRC, PRKCA, PIK3CB, PTGS2, EGFR 5.9718
Cholinergic synapse_Homo sapiens_hsa04725 PRKCG, ACHE, PIK3CA, PRKCB, BCL2, PRKCA, PIK3CB 5.8633
Insulin resistance_Homo sapiens_hsa04931 PIK3CA, PRKCB, INSR, PRKCE, PRKCD, PIK3CB, PPARA 5.9031
Non-small cell lung cancer_Homo sapiens_hsa05223 PRKCG, PIK3CA, PRKCB, PRKCA, PIK3CB, EGFR 6.3215
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 PIK3CA, INSR, KDR, BCL2, PRKCA, TEK, PIK3CB, MET, EGFR, IGF1R 5.4226
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 PRKCG, PIK3CA, PRKCB, SRC, PRKCA, PIK3CB, ESR1 5.7089
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PIK3CA, INSR, PIK3CB, PTGS2, PTGS1 6.3215
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PRKCG, PIK3CA, PRKCB, MMP2, PRKCA, PIK3CB, MMP9 5.7089
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA2, CA4, CA7, CA9, CA14 9.2409
Tight junction_Homo sapiens_hsa04530 PRKCG, CSNK2A1, PRKCB, SRC, PRKCE, PRKCD, PRKCA 5.2842
GnRH signaling pathway_Homo sapiens_hsa04912 PRKCB, SRC, MMP2, PRKCD, PRKCA, EGFR 5.2
Choline metabolism in cancer_Homo sapiens_hsa05231 PRKCG, PIK3CA, PRKCB, PRKCA, PIK3CB, EGFR 4.9454
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CBR1, CYP1A2, CYP1A1, CYP1B1, PTGS2 5.4226
Wnt signaling pathway_Homo sapiens_hsa04310 PRKCG, SMAD3, CSNK2A1, PRKCB, PRKCA, PPARD 4.1901
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, PIK3CA, INSR, PIK3CB, EGFR, IGF1R 4.343
Metabolic pathways_Homo sapiens_hsa01100 CBR1, ALOX15, AKR1B1, PTGS2, TYR, CYP19A1, PTGS1, HSD11B1, FUT7, ALOX5, HSD17B2, CYP1A2, CYP1A1, ALPL, XDH 3.6556
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KDR, MET, EGFR, IGF1R, HSPA1A 3.6955
mTOR signaling pathway_Homo sapiens_hsa04150 PRKCG, PIK3CA, PRKCB, PRKCA, PIK3CB 4.8398
Acute myeloid leukemia_Homo sapiens_hsa05221 PIK3CA, FLT3, PIM1, PIK3CB, PPARD 4.9408
Prostate cancer_Homo sapiens_hsa05215 PIK3CA, BCL2, PIK3CB, EGFR, IGF1R 4.0815
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 PIK3CA, INSR, PIK3CB, IGF1R, HSPA1A 4.7203
Melanoma_Homo sapiens_hsa05218 PIK3CA, PIK3CB, MET, EGFR, IGF1R 4.5258
Central carbon metabolism in cancer_Homo sapiens_hsa05230 PIK3CA, FLT3, PIK3CB, MET, EGFR 4.6313
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PRKCG, PIK3CA, PRKCB, PRKCA, PIK3CB 3.8962
Amoebiasis_Homo sapiens_hsa05146 PRKCG, PIK3CA, PRKCB, PRKCA, PIK3CB 3.8623
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 PRKCG, PRKCB, CNR1, PRKCA, PTGS2 3.8496
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9, EGFR 5.5855
Toxoplasmosis_Homo sapiens_hsa05145 PIK3CA, ALOX5, BCL2, PIK3CB, HSPA1A 3.5581
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, ALOX15, PTGS2, PTGS1 4.7788
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CBR1, CYP1A2, CYP1A1, CYP1B1 4.4756
Type II diabetes mellitus_Homo sapiens_hsa04930 PIK3CA, INSR, PRKCE, PRKCD, PIK3CB 5.2842
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA, PPARD 4.5777
Vascular smooth muscle contraction_Homo sapiens_hsa04270 PRKCG, PRKCB, PRKCE, PRKCD, PRKCA 3.5382
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 PRKCG, PIK3CA, PRKCB, PRKCA, PIK3CB 3.3256
Phospholipase D signaling pathway_Homo sapiens_hsa04072 PIK3CA, INSR, PRKCA, PIK3CB, EGFR 3.2148
MAPK signaling pathway_Homo sapiens_hsa04010 PRKCG, DUSP3, PRKCB, PRKCA, EGFR, HSPA1A 2.971
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 PIK3CA, ADORA3, INSR, PRKCE, PIK3CB 2.9674
Influenza A_Homo sapiens_hsa05164 PIK3CA, PRKCB, PRKCA, PIK3CB, HSPA1A 2.8972
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, PIK3CA, BCL2, PIK3CB, HSPA1A 2.6492
Prolactin signaling pathway_Homo sapiens_hsa04917 PIK3CA, SRC, PIK3CB, ESR1 3.3306
Chemokine signaling pathway_Homo sapiens_hsa04062 PIK3CA, PRKCB, SRC, PRKCD, PIK3CB 2.7833
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.2871
Purine metabolism_Homo sapiens_hsa00230 XDH 0.2995
Taste transduction_Homo sapiens_hsa04742 HTR1E, HTR1D, HTR1A, HTR1B 3.1316
Aldosterone synthesis and secretion_Homo sapiens_hsa04925 PRKCG, PRKCB, PRKCE, PRKCA 3.166
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.3403
Gastric acid secretion_Homo sapiens_hsa04971 PRKCG, PRKCB, CA2, PRKCA 3.2979
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.3807
Pancreatic cancer_Homo sapiens_hsa05212 SMAD3, PIK3CA, PIK3CB, EGFR 3.4637
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 PIK3CA, INSR, PIK3CB, IGF1R 2.967
Long-term depression_Homo sapiens_hsa04730 PRKCG, PRKCB, PRKCA, IGF1R 3.5967
Cell cycle_Homo sapiens_hsa04110 SMAD3 0.4013
Axon guidance_Homo sapiens_hsa04360 MET 0.396
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4013
TNF signaling pathway_Homo sapiens_hsa04668 PIK3CA, PIK3CB, PTGS2, MMP9 2.7481
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 PIK3CA, SRC, PIK3CB, MET 3.2162
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, PRKCB, BCL2, PTGS2 2.971
Melanogenesis_Homo sapiens_hsa04916 PRKCG, PRKCB, PRKCA, TYR 2.8877
GABAergic synapse_Homo sapiens_hsa04727 PRKCG, PRKCB, SRC, PRKCA 3.0528
Platelet activation_Homo sapiens_hsa04611 PIK3CA, SRC, PIK3CB, PTGS1 2.6014
Measles_Homo sapiens_hsa05162 CSNK2A1, PIK3CA, PIK3CB, HSPA1A 2.4429
Small cell lung cancer_Homo sapiens_hsa05222 PIK3CA, BCL2, PIK3CB, PTGS2 3.0849
Neurotrophin signaling pathway_Homo sapiens_hsa04722 PIK3CA, PRKCD, BCL2, PIK3CB 2.6231
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.467
Hepatitis C_Homo sapiens_hsa05160 PIK3CA, PIK3CB, PPARA, EGFR 2.4734
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2, HSPA1A 0.7706
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.738
Colorectal cancer_Homo sapiens_hsa05210 SMAD3, PIK3CA, BCL2, PIK3CB 3.5556
AMPK signaling pathway_Homo sapiens_hsa04152 PIK3CA, INSR, PIK3CB, IGF1R 2.5802
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4862
HTLV-I infection_Homo sapiens_hsa05166 SMAD3, PIK3CA, PIK3CB 0.9813
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, PIK3CA, PIK3CB, IGF1R 2.3933
Pancreatic secretion_Homo sapiens_hsa04972 PRKCG, PRKCB, CA2, PRKCA 2.9435
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 PIK3CA, BCL2, PRKCA, PIK3CB 2.3449
Osteoclast differentiation_Homo sapiens_hsa04380 PIK3CA, PIK3CB 0.9144
Viral carcinogenesis_Homo sapiens_hsa05203 PIK3CA, SRC, PIK3CB 1.2023
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5084
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PIK3CA, INSR, PIK3CB, PPARA 2.3236
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.5226
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.507
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 1.5505
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIK3CA, BCL2, PIM1, PIK3CB 2.2615
Peroxisome_Homo sapiens_hsa04146 XDH 0.5242
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 2.0794
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 PIK3CA, SRC, PIK3CB, EGFR 1.841
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 PIK3CA, PIK3CB 1.0711
Apoptosis_Homo sapiens_hsa04210 PIK3CA, BCL2, PIK3CB 1.6066
Complement and coagulation cascades_Homo sapiens_hsa04610 F10 0.5397
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.5464
Insulin signaling pathway_Homo sapiens_hsa04910 PIK3CA, INSR, PIK3CB 1.6112
T cell receptor signaling pathway_Homo sapiens_hsa04660 PIK3CA, PIK3CB 1.0822
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5764
Bile secretion_Homo sapiens_hsa04976 CA2 0.5738
Dopaminergic synapse_Homo sapiens_hsa04728 PRKCG, PRKCB, PRKCA 1.6934
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2 0.5789
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 PRKCG, PRKCB, PRKCA, ESR1 3.9694
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1, TEK 1.1864
Shigellosis_Homo sapiens_hsa05131 SRC 0.5988
Glutamatergic synapse_Homo sapiens_hsa04724 PRKCG, PRKCB, PRKCA 1.8342
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3 0.5988
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PIK3CA, PIK3CB, IGF1R 2.0021
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3, PIK3CA, PIK3CB 1.9352
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B1 0.63
Circadian entrainment_Homo sapiens_hsa04713 PRKCG, PRKCB, PRKCA 2.0355
Morphine addiction_Homo sapiens_hsa05032 PRKCG, PRKCB, PRKCA 2.0794
Salivary secretion_Homo sapiens_hsa04970 PRKCG, PRKCB, PRKCA 2.0981
Legionellosis_Homo sapiens_hsa05134 HSPA1A 0.6542
Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 PRKCA 0.6542
Insulin secretion_Homo sapiens_hsa04911 PRKCG, PRKCB, PRKCA 2.1498
Leishmaniasis_Homo sapiens_hsa05140 PRKCB, PTGS2 1.3439
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.6778
Vibrio cholerae infection_Homo sapiens_hsa05110 PRKCA 0.6778
Inositol phosphate metabolism_Homo sapiens_hsa00562 PIK3CA, PIK3CB 1.3625
Malaria_Homo sapiens_hsa05144 MET 0.6874
Chronic myeloid leukemia_Homo sapiens_hsa05220 SMAD3, PIK3CA, PIK3CB 2.3236
B cell receptor signaling pathway_Homo sapiens_hsa04662 PIK3CA, PRKCB, PIK3CB 2.3236
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 PIK3CA, PRKCA, PIK3CB 2.3894
Long-term potentiation_Homo sapiens_hsa04720 PRKCG, PRKCB, PRKCA 2.4083
Renal cell carcinoma_Homo sapiens_hsa05211 PIK3CA, PIK3CB, MET 2.4083
Amphetamine addiction_Homo sapiens_hsa05031 PRKCG, PRKCB, PRKCA 2.3942
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1 1.4296
Thyroid hormone synthesis_Homo sapiens_hsa04918 PRKCG, PRKCB, PRKCA 2.3449
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.7093
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 2.3894
Endometrial cancer_Homo sapiens_hsa05213 PIK3CA, PIK3CB, EGFR 2.6684
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.8066
Galactose metabolism_Homo sapiens_hsa00052 AKR1B1 0.8564
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8462
Tyrosine metabolism_Homo sapiens_hsa00350 TYR 0.8066
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.8962
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B1 0.7983
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B1 0.8365
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 PIK3CA, PRKCB, PIK3CB 2.8365
African trypanosomiasis_Homo sapiens_hsa05143 PRKCG, PRKCB, PRKCA 3.0979
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.9052
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1 2.9662
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8962
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2 2.0619
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.2403
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.147
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.4059


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)