TCM Prescription: Shu Gan Jian Wei Pills



Prescription Description
Prescription IDTCMF5292
Pinyin NameShu Gan Jian Wei Wan
Chinese Name舒肝健胃丸
English NameShu Gan Jian Wei Pills
Function Description胃脘痛, 腹胀, 呕吐, 便秘
IndicationsStomach ache disorder, Constipation disorder, Constipation
Disease ICD-11 Category SA51 [Stomach ache disorder (TM1), 胃脘痛 (TM1) ];
SA57 [Constipation disorder (TM1), 便秘 (TM1) ];
ME05.0 [Constipation, 便秘 ];
Human Tissues Associated with IndicationStomach, Large Intestine
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH890 Cortex magnoliae officinalis 厚朴 TCMH890 ITSAM1591-14
TCMH2265 Cyperus rotundus 香附 TCMH2265 GENG1049-15
TCMH104 Paeonia lactiflora 白芍 TCMH104 ITSAH2416-14
TCMH228 Bupleurum chinense 柴胡 TCMH228 ITSAM2218-14
TCMH1695 Pericarpium citri reticulatae viride 青皮 TCMH1695
TCMH2281 Citrus medica 香橼 TCMH2281 ITSAJ4663-14
TCMH243 Pericarpium citri reticulatae 陈皮 TCMH243
TCMH2066 Santalum album 檀香 TCMH2066 ITSAJ4584-14
TCMH512 Fructus amomi rotundus 豆蔻 TCMH512
TCMH2618 Citrus aurantium 枳壳 TCMH2618 ITSAA1279-14
TCMH1026 Gallus gallus domesticus 鸡内金 TCMH1026 ACLB009-06
TCMH182 Areca catechu 槟榔 TCMH182 ITSAA732-14
TCMH2376 Corydalis yanhusuo 延胡索 TCMH2376
TCMH2188 Trogopterus xanthipes 五灵脂 TCMH2188
TCMH1662 Pharbitis nil 牵牛子 TCMH1662
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT107 GRIK2 Glutamate receptor ionotropic kainate 2 Ion channel Q13002
TCMT109 GRIA2 Glutamate receptor ionotropic, AMPA 2 Ion channel P42262
TCMT110 GRIA4 Glutamate receptor ionotropic, AMPA 4 Ion channel P48058
TCMT111 GRIK5 Glutamate receptor ionotropic kainate 5 Ion channel Q16478
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT114 CNR2 Cannabinoid CB2 receptor GPCR P34972
TCMT115 CNR1 Cannabinoid CB1 receptor GPCR P21554
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT160 HTR7 Serotonin 7 (5-HT7) receptor GPCR P34969
TCMT17 POLB DNA polymerase beta Transferase P06746
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT221 ABCB11 Bile salt export pump Transporter O95342
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT289 TBXAS1 Thromboxane-A synthase Isomerase P24557
TCMT292 CHRM1 Muscarinic acetylcholine receptor M1 GPCR P11229
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT313 HTR2B Serotonin 2b (5-HT2b) receptor GPCR P41595
TCMT315 HTR6 Serotonin 6 (5-HT6) receptor GPCR P50406
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT337 XPO1 Exportin-1 Unclassified O14980
TCMT34 CYP2D6 Cytochrome P450 2D6 Oxidoreductase P10635
TCMT36 HTR1A Serotonin 1a (5-HT1a) receptor GPCR P08908
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT37 HTR2A Serotonin 2a (5-HT2a) receptor GPCR P28223
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT551 CHRM4 Muscarinic acetylcholine receptor M4 GPCR P08173
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT561 NT5E 5'-nucleotidase Hydrolase P21589
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT598 TOP1 DNA topoisomerase I Isomerase P11387
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT615 SENP8 Sentrin-specific protease 8 Protease Q96LD8
TCMT616 SENP7 Sentrin-specific protease 7 Protease Q9BQF6
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT636 POLA1 DNA polymerase alpha subunit Transferase P09884
TCMT643 ADRA1A Alpha-1a adrenergic receptor GPCR P35348
TCMT646 HTR5A Serotonin 5a (5-HT5a) receptor GPCR P47898
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT651 DRD3 Dopamine D3 receptor GPCR P35462
TCMT653 GRM1 Metabotropic glutamate receptor 1 GPCR Q13255
TCMT654 GRM5 Metabotropic glutamate receptor 5 GPCR P41594
TCMT655 GRM2 Metabotropic glutamate receptor 2 GPCR Q14416
TCMT656 GRM3 Metabotropic glutamate receptor 3 GPCR Q14832
TCMT657 GRM4 Metabotropic glutamate receptor 4 GPCR Q14833
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT660 GRM8 Metabotropic glutamate receptor 8 GPCR O00222
TCMT664 SLC1A1 Excitatory amino acid transporter 3 Transporter P43005
TCMT678 XIAP Inhibitor of apoptosis protein 3 Transferase P98170
TCMT679 MPEG1 Macrophage-expressed gene 1 protein Unclassified Q2M385
TCMT680 KAT2B Histone acetyltransferase PCAF Transferase Q92831
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT853 SIGMAR1 Sigma opioid receptor Unclassified Q99720


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1175 Human immunodeficiency virus
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1183 Candida albicans SC5314
TCMT1189 Pseudomonas fluorescens
TCMT1201 Staphylococcus epidermidis ATCC 12228
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1292 Japanese encephalitis virus
TCMT1294 Human parainfluenza virus 3
TCMT1297 Punta Toro virus
TCMT1318 Human T-lymphotropic virus 1
TCMT1321 Staphylococcus hominis
TCMT1336 Yellow fever virus
TCMT1337 Dengue virus type 4
TCMT1338 Rift Valley fever virus
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1352 Colletotrichum truncatum
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0007187 None ADORA1, ADRA1A, CHRM1, CHRM2, CHRM4, CNR1, CNR2, DRD1, DRD2, DRD3, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR5A, HTR6, HTR7 16.5757
[BP] GO:0007188 None ADORA1, ADRA1A, CHRM1, CHRM2, CHRM4, CNR1, DRD1, DRD2, DRD3, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR5A, HTR7 14.7332
[BP] GO:0007193 None ADORA1, CHRM1, CHRM2, CHRM4, DRD2, DRD3, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR5A, HTR7 14.576
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, ADRA1A, AKR1B1, AURKB, AXL, CA12, CA2, CA7, CHRM1, CNR1, CNR2, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, F10, F3, FABP3, FABP4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HSD17B1, HSD17B2, HTR1A, HTR2A, HTR2B, HTR7, KDR, MET, POLA1, POLB, PPARA, SLC1A1, SRC, TNKS, TNKS2, XDH 13.2098
[BP] GO:0099536 None CHRM1, CHRM2, CHRM4, CNR1, DRD1, DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR6, HTR7, SLC1A1 10.964
[BP] GO:0099537 None CHRM1, CHRM2, CHRM4, CNR1, DRD1, DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR6, HTR7, SLC1A1 10.964
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, ADRA1A, CA2, CA7, CNR1, CNR2, DRD1, DRD2, DRD3, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR2A 10.964
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, ADRA1A, CA2, CA7, CNR1, CNR2, DRD1, DRD2, DRD3, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR2A 10.964
[BP] GO:0007268 None CHRM1, CHRM2, CHRM4, DRD1, DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR6, HTR7, SLC1A1 9.93422
[BP] GO:0098916 None CHRM1, CHRM2, CHRM4, DRD1, DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR6, HTR7, SLC1A1 9.93422
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, CNR1, DRD1, DRD2, GRM1, GRM3, GRM5, GRM8, HTR2A 9.2222
[BP] GO:0010647 positive regulation of cell communication ADORA1, ADRA1A, AKR1B1, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, F10, F3, FLT3, GRM1, HTR2A, HTR2B, HTR6, KDR, MET, MMP12, PTPN1, SRC, TNKS, TNKS2, XDH 8.35929
[BP] GO:0007267 None ADORA1, ADRA1A, CHRM1, CHRM2, CHRM4, CNR1, DRD1, DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR6, HTR7, SLC1A1 8.3463
[BP] GO:0023056 positive regulation of signaling ADORA1, ADRA1A, AKR1B1, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, F10, F3, FLT3, GRM1, HTR2A, HTR2B, HTR6, KDR, MET, MMP12, PTPN1, SRC, TNKS, TNKS2, XDH 8.3463
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA1, ADORA3, ADRA1A, CA2, CHRM1, CHRM2, CHRM4, CNR1, CNR2, DRD1, DRD2, DRD3, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, SIGMAR1, SRC 8.18716
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, ADRA1A, CA2, CA7, CNR1, CNR2, DRD2 7.89706
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, ADRA1A, AKR1B1, AURKB, AXL, CA2, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, F10, F3, FLT3, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR6, IGF1R, KDR, MET, MMP12, PTPN1, SRC, TNKS, TNKS2, XDH 7.89706
[BP] GO:0007200 None ADRA1A, CHRM1, CHRM2, CHRM4, DRD1, DRD2, GRM5, HTR2A, HTR2B 7.79214
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, ADRA1A, AKR1B1, AURKB, AXL, CA2, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, F10, F3, FLT3, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR6, IGF1R, KDR, MET, MMP12, PTPN1, SRC, TNKS, TNKS2, XDH 7.77574
[BP] GO:0023052 None ADORA1, ADRA1A, CHRM1, CHRM2, CHRM4, CNR1, DRD1, DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR6, HTR7, SLC1A1 7.67002
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, AXL, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, FABP3, GRIK5, GRM5, HSD17B2, HTR5A, IGF1R, POLB, PPARA, SRC, TYR 7.46601
[BP] GO:0010033 response to organic substance ADRA1A, AKR1B1, ALPL, AXL, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, FABP3, FABP4, FLT3, GRIK5, GRM5, HSD17B2, HTR5A, IGF1R, KDR, POLB, PPARA, SRC, TYR 7.36024
[BP] GO:0042493 response to drug ADRA1A, AKR1B1, AXL, CA9, CNR1, CNR2, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, FABP3, HTR2A, HTR2B, KDR, POLB, SRC, TOP1 7.33923
[BP] GO:0042221 response to chemical ADRA1A, AKR1B1, ALPL, AXL, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, FABP3, FABP4, FLT3, GRIK5, GRM5, HSD17B2, HTR2A, HTR2B, HTR5A, IGF1R, KDR, POLB, PPARA, SRC, TOP1, TYR 7.33906
[BP] GO:0007154 None ADORA1, ADRA1A, AXL, CHRM1, CHRM2, CHRM4, CNR1, DRD1, DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR6, HTR7, SLC1A1 7.11412
[BP] GO:0032501 multicellular organismal process ADORA1, ADRA1A, AKR1B1, AKR1B10, ALOX5, ALPL, AXL, CHRM1, CNR1, CNR2, CYP19A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, F10, F3, FABP4, GRM1, GRM5, GRM8, HSD17B2, HTR1A, HTR2A, HTR2B, HTR7, IGF1R, MET, MMP12, PIM1, PPARA, SRC, TNKS2, TOP1, TYR 7.03576
[BP] GO:0042592 homeostatic process ADORA1, ADRA1A, AKR1B1, AXL, CA12, CA2, CA7, CNR1, DRD1, DRD2, DRD3, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HTR2A, HTR2B, MET, POLA1, POLB, SRC 7.03576
[BP] GO:0007215 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 7.02557
[BP] GO:0007210 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 7.01143
[BP] GO:0098664 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 7.01143
[BP] GO:0007165 signal transduction ADORA1, ADORA3, ADRA1A, AKR1B1, AXL, CA2, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP1B1, DRD1, DRD2, DRD3, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, PIM1, POLB, PPARA, PTPN1, SIGMAR1, SRC, TNKS, TNKS2 6.67347
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, TYR 6.62871
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, CA2, CA7, CNR1, DRD1, DRD2, DRD3, HTR2A, HTR2B, KDR, SRC, TNKS, TNKS2 6.2978
[BP] GO:0009967 positive regulation of signal transduction ADORA1, ADRA1A, AKR1B1, AXL, CSNK2A1, CYP1B1, DRD2, DRD3, F10, F3, FLT3, GRM1, HTR2A, HTR2B, HTR6, KDR, MET, MMP12, PTPN1, SRC, TNKS, TNKS2, XDH 6.23913
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, KDR, POLB, SRC 6.19034
[BP] GO:0050795 None ADORA1, CNR1, DRD2, DRD3, HTR1A, HTR2A, HTR2B 5.97227
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, ALPL, AURKB, AXL, CA2, CA9, CHRM2, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, F10, F3, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HSD17B2, HTR1A, HTR2A, HTR2B, HTR5A, IGF1R, KDR, MMP12, POLA1, POLB, PPARA, PTPN1, SRC, TOP1, TYR 5.90645
[BP] GO:2000021 regulation of ion homeostasis ADORA1, CA2, CA7, DRD1, DRD2, DRD3, HTR2A, HTR2B, KDR, SRC 5.90645
[BP] GO:0003018 None ADORA1, ADRA1A, CHRM1, DRD1, HTR1A, HTR2A, HTR2B, HTR7, SRC 5.82442
[BP] GO:0097756 None ADORA1, ADRA1A, HTR1A, HTR2A, HTR2B, HTR7 5.77451
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD2, FABP3, FABP4, FUT7, HSD17B1, HSD17B2, MET, PPARA, TBXAS1 5.74189
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, ADRA1A, AKR1B1, AXL, CYP1B1, DRD2, F10, F3, FLT3, GRM1, HTR2A, HTR2B, HTR6, KDR, MET, PTPN1, SRC, XDH 5.61973
[BP] GO:0097746 None ADORA1, ADRA1A, CHRM1, DRD1, HTR1A, HTR2A, HTR2B, HTR7 5.34564
[BP] GO:0035296 None ADORA1, ADRA1A, CHRM1, DRD1, HTR1A, HTR2A, HTR2B, HTR7 5.34564
[BP] GO:0007196 None GRM1, GRM3, GRM5, GRM8 5.25729
[BP] GO:0006939 None ADRA1A, DRD1, DRD2, HTR2A, HTR2B, HTR7 5.25729
[BP] GO:0050880 None ADORA1, ADRA1A, CHRM1, DRD1, HTR1A, HTR2A, HTR2B, HTR7 5.16021
[BP] GO:0035150 None ADORA1, ADRA1A, CHRM1, DRD1, HTR1A, HTR2A, HTR2B, HTR7 5.1399
[BP] GO:0048878 chemical homeostasis ADRA1A, AKR1B1, CA12, CA2, CA7, CNR1, DRD1, DRD2, DRD3, FABP3, FABP4, GRIK5, GRM1, GRM5, HTR2A, HTR2B, MET 5.07457
[BP] GO:0033993 response to lipid ALPL, AXL, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, FABP3, FLT3, HSD17B2, HTR5A, SRC, TYR 5.04261
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, ADRA1A, AKR1B1, CDC25B, CHRM1, CSNK2A1, CYP1B1, DRD2, DRD3, F3, FABP3, FLT3, HTR1A, HTR2A, HTR2B, IGF1R, KDR, MMP12, PIM1, SRC, XDH 5.03446
[BP] GO:0014070 response to organic cyclic compound ALPL, CA2, CA9, CNR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, FLT3, HTR5A, SRC, TYR 5.01984
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, AXL, CA2, CA7, CHRM1, CNR1, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, F10, F3, GRIK5, GRM5, HTR1A, HTR2A, HTR2B, IGF1R, KDR, MET, MMP12, PPARA, PTPN1, SRC 4.98356
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, ADRA1A, AKR1B1, AURKB, AXL, CA2, CA7, CDC25B, CHRM1, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, F10, F3, FABP3, FLT3, GRIK5, GRM1, GRM5, HTR1A, HTR2A, HTR2B, HTR6, IGF1R, KDR, MET, MMP12, PIM1, PPARA, PTPN1, SRC, TNKS, TNKS2, XDH 4.9469
[BP] GO:0003013 None ADORA1, ADRA1A, CHRM1, DRD1, HTR1A, HTR2A, HTR2B, HTR7, SRC 4.90883
[BP] GO:0042310 None ADRA1A, HTR1A, HTR2A, HTR2B, HTR7 4.86167
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, ADRA1A, AKR1B1, AXL, CNR1, CSNK2A1, CYP1B1, DRD2, DRD3, F10, F3, FABP4, FLT3, GRM1, HTR2A, HTR2B, HTR6, KDR, MET, MMP12, PTPN1, SRC, TNKS, TNKS2, XDH 4.79536
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, ADRA1A, AKR1B1, AURKB, AXL, CA2, CA7, CDC25B, CHRM1, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, F10, F3, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HTR1A, HTR2A, HTR2B, HTR6, IGF1R, KDR, MET, MMP12, PIM1, PPARA, PTPN1, SLC1A1, SRC, TNKS, TNKS2, XDH 4.69348
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, CNR2, DRD1, DRD2, HTR2A 4.60326
[BP] GO:0044092 negative regulation of molecular function ADORA3, AURKB, CNR1, CNR2, CSNK2A1, CYP1B1, CYP2D6, DRD2, DRD3, FABP4, GRM3, IGF1R, MET, PIM1, PPARA, PTPN1, SRC, TNKS 4.58808
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, CNR1, DRD1, DRD2, DRD3, TNKS, TNKS2 4.58613
[BP] GO:0007216 None GRM1, GRM3, GRM5, GRM8 4.49153
[BP] GO:0007198 None HTR1A, HTR5A, HTR7 4.42353
[BP] GO:0006730 one-carbon metabolic process CA12, CA2, CA4, CA7, CA9 4.4161
[BP] GO:0042391 None ADORA1, ADRA1A, CNR1, CNR2, DRD1, GRIA2, GRIA4, GRIK5, GRM5, KDR, SRC 4.41408
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, ADRA1A, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, DRD2, DRD3, F10, F3, FLT3, GRM1, HTR2A, HTR2B, HTR6, IGF1R, KDR, MET, PTPN1, SRC, XDH 4.31476
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, HSD17B1, HSD17B2 4.29012
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CNR1, CYP19A1, CYP1A1, CYP1B1, DRD2, HSD17B1, HSD17B2, HTR1A, HTR2A 4.29012
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, CSNK2A1, DRD1, DRD2, DRD3, HTR1A 4.2302
[BP] GO:0003008 None ADORA1, ADRA1A, AKR1B1, CHRM1, CNR1, CNR2, CYP1B1, DRD1, DRD2, DRD3, GRM1, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR7, SRC, TYR 4.22288
[BP] GO:0051952 None ADORA1, CNR1, DRD1, DRD2, DRD3, HTR2A 4.20967
[BP] GO:0018958 None AKR1B1, DRD1, DRD2, DRD3, HTR1A, TYR 4.14591
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, FUT7, HTR2B, PIM1, PPARA, TBXAS1, TYR, XDH 4.12022
[BP] GO:0045776 None ADORA1, CNR1, DRD2, DRD3, PPARA 4.12022
[BP] GO:0007197 None CHRM1, CHRM2, CHRM4 4.09157
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, AKR1B10, ALOX5, ALPL, AURKB, AXL, CA12, CA2, CA4, CA7, CA9, CDC25B, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, F10, F3, FABP3, FABP4, FLT3, FUT7, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSD17B1, HSD17B2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, MMP12, PIM1, POLA1, POLB, PPARA, PTPN1, SIGMAR1, SLC1A1, SRC, TBXAS1, TNKS, TNKS2, TOP1, TYR, XDH 4.09157
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, SRC 4.08211
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ADRA1A, CDC25B, DRD1, DRD2, DRD3, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HTR2A, HTR2B, IGF1R, KDR, PPARA, PTPN1, SRC, XDH 4.0497
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, CDC25B, CHRM1, CSNK2A1, DRD2, DRD3, F3, FLT3, HTR1A, HTR2A, HTR2B, IGF1R, KDR, MMP12, PIM1 4.0497
[BP] GO:0015701 bicarbonate transport CA12, CA2, CA4, CA7, CA9 4.04141
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, CHRM1, CHRM4, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, F10, F3, IGF1R, KDR, MET, SRC 4.01953
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ADRA1A, CDC25B, DRD1, DRD2, DRD3, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HTR2A, HTR2B, IGF1R, KDR, PPARA, PTPN1, SRC, XDH 4.00556
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CNR1, CYP1A1, DRD3, FABP3, FLT3, HTR2A, HTR2B, PPARA, SRC 3.93302
[BP] GO:0048148 None DRD1, DRD2, DRD3, HTR2A 3.92387
[BP] GO:2001023 None CNR1, DRD1, DRD2, DRD3, HTR2A, MET 3.87078
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, ADRA1A, AURKB, CDC25B, CNR1, CNR2, CSNK2A1, DRD1, DRD2, DRD3, F3, FABP4, FLT3, GRM1, GRM3, GRM5, HTR2A, HTR2B, IGF1R, PTPN1, SRC, TNKS, XDH 3.86075
[BP] GO:0032845 None ADORA1, DRD2, HTR2A, HTR2B, SRC, TNKS, TNKS2 3.85569
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AURKB, AXL, CNR1, CSNK2A1, CYP1B1, F3, FLT3, GRIK5, HTR2B, IGF1R, KDR, MET, PIM1, PPARA, PTPN1, SIGMAR1, SRC, XDH 3.85569
[BP] GO:0007207 None CHRM1, CHRM2, CHRM4 3.85485
[BP] GO:0051896 regulation of protein kinase B signaling AXL, DRD2, DRD3, F10, F3, MET, SRC, XDH 3.8454
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, CNR1, CSNK2A1, CYP1B1, F3, FLT3, GRIK5, HTR2B, IGF1R, KDR, MET, PIM1, PTPN1, SIGMAR1, SRC, XDH 3.7157
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6, TBXAS1 3.68111
[BP] GO:0065007 biological regulation ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, AURKB, AXL, CA12, CA2, CA7, CA9, CDC25B, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, F10, F3, FABP3, FABP4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSD17B1, HSD17B2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, MMP12, PIM1, POLA1, POLB, PPARA, PTPN1, SIGMAR1, SLC1A1, SRC, TNKS, TNKS2, TOP1, XDH 3.67309
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2D6, TBXAS1 3.65928
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD2, FABP3, FABP4, FUT7, MET, PPARA, TBXAS1 3.65524
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.63653
[BP] GO:0009719 response to endogenous stimulus ADRA1A, AKR1B1, ALPL, CA2, CA9, CSNK2A1, CYP1A2, DRD1, FABP3, FLT3, GRM5, HTR5A, IGF1R, PPARA, SRC 3.56194
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, ADRA1A, AURKB, CDC25B, CNR1, CNR2, CSNK2A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, F3, FABP4, FLT3, GRM1, GRM3, GRM5, HTR2A, HTR2B, IGF1R, MET, PIM1, PPARA, PTPN1, SRC, TNKS, XDH 3.54509
[BP] GO:0032502 developmental process ACHE, ADORA1, ADRA1A, AKR1B1, ALPL, AURKB, AXL, CA2, CA9, CDC25B, CHRM1, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, FABP4, FLT3, FUT7, HSD17B2, HTR2A, HTR2B, HTR5A, KDR, MET, PIM1, POLB, PPARA, SIGMAR1, SRC, TNKS2, TYR 3.53702
[BP] GO:0006690 icosanoid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6, TBXAS1 3.53702
[BP] GO:0019932 second-messenger-mediated signaling ADRA1A, DRD1, DRD2, DRD3, GRM5, HTR2B, HTR5A, KDR 3.53702
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ADRA1A, DRD2, FLT3, GRM1, HTR2A, HTR2B, KDR, PTPN1, SRC, XDH 3.53702
[BP] GO:0001975 None CNR2, DRD1, DRD2, DRD3 3.51594
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, HTR1A, TYR 3.50207
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, AURKB, CA2, CYP1A1, DRD1, DRD2, DRD3, GRM1, HTR2A, HTR2B, POLB, PPARA, SRC, TYR 3.47641
[BP] GO:0051940 None DRD1, DRD2, DRD3 3.47553
[BP] GO:0051584 None DRD1, DRD2, DRD3 3.47553
[BP] GO:0015711 organic anion transport CA12, CA2, CA4, CA7, CA9, DRD2, DRD3, FABP3, PPARA, SLC1A1 3.47553
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1, HSD17B2 3.46379
[BP] GO:0006811 None ADRA1A, CA12, CA2, CA4, CA7, CA9, DRD1, DRD2, DRD3, FABP3, GRIA2, GRIA4, GRIK5, HTR2A, HTR2B, PPARA, SLC1A1 3.41053
[BP] GO:0010243 response to organonitrogen compound AKR1B1, CNR1, CNR2, DRD1, DRD2, DRD3, FABP3, FLT3, GRM5, IGF1R, PPARA, SRC, TYR 3.40966
[BP] GO:0014059 None CNR1, DRD2, DRD3, HTR2A 3.40822
[BP] GO:0008283 cell proliferation ACHE, AURKB, CHRM1, CHRM4, CYP1A1, FLT3, HTR1A, MET, PIM1, POLA1, SRC, TYR 3.32732
[BP] GO:0071073 None FABP3, HTR2A, HTR2B 3.31877
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, DRD1, DRD2, DRD3, GRIK5, HTR1A, SLC1A1 3.31209
[BP] GO:0009725 response to hormone ADRA1A, AKR1B1, ALPL, CA2, CA9, CSNK2A1, CYP1A2, FABP3, FLT3, HTR5A, PPARA, SRC 3.3011
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CNR1, CNR2, CYP19A1, DRD1, DRD2, DRD3, F3, FABP4, KDR, MET, MMP12, PPARA 3.28379
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, DRD1, DRD2, HTR2A, MET 3.26564
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, AXL, CHRM4, CSNK2A1, DRD2, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, PTPN1, SRC, TNKS, TNKS2 3.25097
[BP] GO:0001659 None ADORA1, DRD1, DRD2, HTR2A 3.24674
[BP] GO:0050801 ion homeostasis ADRA1A, CA12, CA2, CA7, DRD1, DRD2, DRD3, FABP3, GRM1, GRM5, HTR2A, HTR2B 3.24674
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1, HSD17B2 3.23778
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, CNR1, CSNK2A1, CYP1B1, F3, FLT3, GRIK5, HTR2B, IGF1R, KDR, PIM1, PTPN1, SIGMAR1, SRC, XDH 3.23026
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, ADRA1A, CA2, CA7, DRD1, DRD2 3.21715
[BP] GO:2001225 regulation of chloride transport CA2, CA7, GRM5 3.19446
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.19446
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, HTR2A, HTR2B, PPARA, SRC 3.18313
[BP] GO:1903530 regulation of secretion by cell ACHE, ADORA1, CNR1, CYP19A1, DRD2, DRD3, GRIK5, HTR1A, HTR2A, HTR2B, MMP12, SRC 3.1785
[BP] GO:0006468 protein phosphorylation AURKB, AXL, CDC25B, CSNK2A1, DRD1, FLT3, HTR2B, IGF1R, KDR, MET, PIM1, SRC, TNKS, TOP1 3.17835
[BP] GO:1900543 None DRD2, DRD3, GRM3, GRM8, PPARA 3.16698
[BP] GO:0051347 positive regulation of transferase activity ADORA1, AURKB, CDC25B, DRD2, FLT3, GRM1, GRM5, HTR2A, HTR2B, PTPN1, SRC, TNKS 3.16615
[BP] GO:0010035 response to inorganic substance AKR1B1, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, DRD2, FABP4, KDR, SRC 3.15253
[BP] GO:0051049 regulation of transport ACHE, ADORA1, AXL, CA2, CA7, CHRM1, CNR1, CYP19A1, DRD1, DRD2, DRD3, GRIK5, GRM5, HTR1A, HTR2A, HTR2B, MMP12, PPARA, PTPN1, SRC 3.15247
[BP] GO:0050890 None ADORA1, CHRM1, CNR1, DRD1, DRD2, DRD3, GRM5, HTR2A 3.15148
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, SRC 3.15065
[BP] GO:0045980 None DRD2, DRD3, GRM3, GRM8, PPARA 3.15065
[BP] GO:1901698 response to nitrogen compound AKR1B1, CNR1, CNR2, DRD1, DRD2, DRD3, FABP3, FLT3, GRM5, IGF1R, PPARA, SRC, TYR 3.11019
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC 3.11019
[BP] GO:0002031 None DRD2, DRD3, HTR2B 3.08709
[BP] GO:0021885 forebrain cell migration AXL, DRD1, DRD2, HTR6 3.07602
[BP] GO:0050789 regulation of biological process ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, AURKB, AXL, CA2, CA7, CA9, CDC25B, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, F10, F3, FABP3, FABP4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, MMP12, PIM1, POLA1, POLB, PPARA, PTPN1, SIGMAR1, SLC1A1, SRC, TNKS, TNKS2, TOP1, XDH 3.07602
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ADRA1A, CDC25B, DRD1, DRD2, FABP3, FLT3, GRM1, GRM5, HTR2A, HTR2B, KDR, PTPN1, SRC, XDH 3.07452
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ADRA1A, CDC25B, DRD1, DRD2, FABP3, FLT3, GRM1, GRM5, HTR2A, HTR2B, KDR, PTPN1, SRC, XDH 3.07452
[BP] GO:0048511 rhythmic process AXL, CSNK2A1, DRD2, DRD3, HTR7, PPARA, SRC, TOP1 3.03665
[BP] GO:1903522 None ADORA1, ADORA3, ADRA1A, CHRM1, CHRM2, DRD2, HTR2A, SLC1A1 3.0288
[BP] GO:0060078 None ADORA1, GRIA2, GRIA4, GRIK5, GRM5 3.0288
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ADRA1A, DRD2, FLT3, GRM1, HTR2A, HTR2B, IGF1R, KDR, PTPN1, SRC, XDH 2.99755
[BP] GO:0032467 None AURKB, CDC25B, DRD2, DRD3 2.99626
[BP] GO:0014075 None CNR2, DRD1, DRD2, DRD3 2.95542
[BP] GO:0043269 regulation of ion transport ADORA1, CA2, CA7, CHRM1, CNR1, DRD1, DRD2, DRD3, GRM5, HTR1A, HTR2A 2.93589
[BP] GO:0006631 fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, PPARA, TBXAS1 2.92711
[BP] GO:0051046 None ACHE, ADORA1, CNR1, CYP19A1, DRD2, DRD3, GRIK5, HTR1A, HTR2A, HTR2B, MMP12, SRC 2.91664
[BP] GO:0048583 regulation of response to stimulus ADORA1, ADRA1A, AKR1B1, AURKB, AXL, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, F10, F3, FABP4, FLT3, GRM1, HTR2A, HTR2B, HTR6, IGF1R, KDR, MET, MMP12, PPARA, PTPN1, SRC, TNKS, TNKS2, XDH 2.91664
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.89467
[BP] GO:0060134 None DRD1, DRD2, DRD3 2.89467
[BP] GO:0032230 positive regulation of synaptic transmission, GABAergic ADRA1A, CA2, CA7 2.89467
[BP] GO:0051781 None AURKB, CDC25B, DRD2, DRD3, HTR2B 2.87445
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPL, AURKB, AXL, CDC25B, CSNK2A1, DRD1, DRD2, FLT3, HTR2B, IGF1R, KDR, MET, PIM1, POLB, PTPN1, SRC, TNKS, TOP1, XDH 2.86391
[BP] GO:0051338 regulation of transferase activity ADORA1, AURKB, CDC25B, DRD2, FABP4, FLT3, GRM1, GRM5, HTR2A, HTR2B, IGF1R, PTPN1, SRC, TNKS 2.85296
[BP] GO:0045860 positive regulation of protein kinase activity ADORA1, CDC25B, DRD2, FLT3, GRM1, GRM5, HTR2A, HTR2B, PTPN1, SRC 2.81745
[BP] GO:0051580 None DRD1, DRD2, DRD3 2.80291
[BP] GO:0051967 None ADORA1, DRD2, HTR2A 2.80291
[BP] GO:0008217 None ADORA1, ADRA1A, CNR1, DRD2, DRD3, PPARA 2.79143
[BP] GO:0044057 None ADORA1, ADORA3, ADRA1A, CHRM1, CHRM2, DRD2, DRD3, GRM1, HTR2A, SLC1A1 2.78903
[BP] GO:0050877 None ADORA1, CHRM1, CNR1, CNR2, CYP1B1, DRD1, DRD2, DRD3, GRM1, GRM5, GRM8, HTR2A, TYR 2.78626
[BP] GO:0006584 None AKR1B1, DRD1, DRD2, DRD3 2.77665
[BP] GO:0009712 None AKR1B1, DRD1, DRD2, DRD3 2.77665
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, HSD17B1, HSD17B2, TBXAS1, TYR, XDH 2.77665
[BP] GO:0098771 inorganic ion homeostasis ADRA1A, CA12, CA2, CA7, DRD1, DRD2, DRD3, GRM1, GRM5, HTR2A, HTR2B 2.75584
[BP] GO:0048513 animal organ development ACHE, ADRA1A, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, FLT3, HSD17B2, KDR, POLB, PPARA, SRC, TYR 2.75539
[BP] GO:0051588 None DRD1, DRD2, DRD3, GRIK5, HTR1A 2.75539
[BP] GO:0030818 None DRD2, DRD3, GRM3, GRM8 2.74515
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3 2.74193
[BP] GO:0019933 None ADRA1A, DRD1, DRD2, DRD3, HTR5A 2.73945
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, CYP19A1, CYP1B1, DRD1, DRD2, F10, F3, IGF1R, KDR, MET, SRC 2.73945
[BP] GO:0042325 regulation of phosphorylation ADORA1, ADRA1A, CDC25B, DRD1, DRD2, FABP4, FLT3, GRM1, GRM5, HTR2A, HTR2B, IGF1R, KDR, PPARA, PTPN1, SRC, XDH 2.73745
[BP] GO:0001963 None DRD1, DRD2, DRD3 2.7354
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6, TBXAS1 2.72237
[BP] GO:0097366 None CNR2, DRD1, DRD2, DRD3 2.71876
[BP] GO:0055082 cellular chemical homeostasis ADRA1A, CA2, CA7, DRD1, DRD2, DRD3, GRIK5, GRM1, GRM5, HTR2A, HTR2B 2.70808
[BP] GO:1900542 None DRD1, DRD2, DRD3, GRM3, GRM8, HTR2A, PPARA 2.70469
[BP] GO:0030803 None DRD2, DRD3, GRM3, GRM8 2.68584
[BP] GO:0019725 cellular homeostasis ADRA1A, CA2, CA7, DRD1, DRD2, DRD3, GRIK5, GRM1, GRM5, HTR2A, HTR2B, POLA1 2.67835
[BP] GO:0007610 None CNR1, DRD1, DRD2, DRD3, GRM1, GRM5, HTR1A, HTR2A, HTR2B, PPARA 2.67835
[BP] GO:0035556 intracellular signal transduction ADRA1A, AKR1B1, AXL, CYP1B1, DRD1, DRD2, DRD3, GRM5, HTR2A, HTR2B, HTR5A, IGF1R, KDR, MET, POLB, PTPN1, SRC 2.66882
[BP] GO:0045859 regulation of protein kinase activity ADORA1, CDC25B, DRD2, FABP4, FLT3, GRM1, GRM5, HTR2A, HTR2B, IGF1R, PTPN1, SRC 2.66772
[BP] GO:0071071 None FABP3, HTR2A, HTR2B 2.66772
[BP] GO:0007213 None CHRM1, CHRM2, CHRM4 2.66772
[BP] GO:0032225 None DRD1, DRD2, DRD3 2.66772
[BP] GO:0050433 None CNR1, DRD2, DRD3, HTR2A 2.66246
[BP] GO:0006820 anion transport CA12, CA2, CA4, CA7, CA9, DRD2, DRD3, FABP3, PPARA, SLC1A1 2.65643
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, AURKB, AXL, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, FABP3, FABP4, GRM3, GRM8, HTR2A, HTR2B, IGF1R, KDR, MET, MMP12, PIM1, PPARA, PTPN1, SRC, TNKS, TNKS2, XDH 2.64964
[BP] GO:0006140 None DRD1, DRD2, DRD3, GRM3, GRM8, HTR2A, PPARA 2.64364
[BP] GO:0033674 positive regulation of kinase activity ADORA1, CDC25B, DRD2, FLT3, GRM1, GRM5, HTR2A, HTR2B, PTPN1, SRC 2.6415
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ADRA1A, CDC25B, DRD1, DRD2, FABP4, FLT3, GRM1, GRM5, HTR2A, HTR2B, IGF1R, KDR, PTPN1, SRC, XDH 2.6415
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPL, AURKB, AXL, CDC25B, CSNK2A1, DRD1, DRD2, FLT3, HTR2B, IGF1R, KDR, MET, PIM1, POLB, PTPN1, SRC, TNKS, TOP1, XDH 2.6415
[BP] GO:0030815 None DRD2, DRD3, GRM3, GRM8 2.63902
[BP] GO:0030817 None DRD1, DRD2, DRD3, GRM3, GRM8 2.62561
[BP] GO:1900372 None DRD2, DRD3, GRM3, GRM8 2.60868
[BP] GO:0030809 None DRD2, DRD3, GRM3, GRM8 2.60868
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.60654
[BP] GO:0050794 regulation of cellular process ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, AURKB, AXL, CA2, CA7, CA9, CDC25B, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, F10, F3, FABP3, FABP4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, MMP12, PIM1, POLA1, POLB, PPARA, PTPN1, SIGMAR1, SRC, TNKS, TNKS2, XDH 2.6006
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, FLT3, GRM1, HTR2A, HTR2B, IGF1R, PTPN1, SRC 2.5948
[BP] GO:0001676 long-chain fatty acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2D6, TBXAS1 2.5948
[BP] GO:0019935 None ADRA1A, DRD1, DRD2, DRD3, HTR5A 2.5948
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ADRA1A, CDC25B, DRD2, FLT3, GRM1, GRM5, HTR2A, HTR2B, KDR, PTPN1, SRC, XDH 2.59361
[BP] GO:0030800 None DRD2, DRD3, GRM3, GRM8 2.58511
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, HTR2B, IGF1R, KDR, MET, PIM1, PPARA, PTPN1, SRC 2.5733
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, ADRA1A, AKR1B1, ALPL, AXL, CA2, CHRM1, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, FLT3, HSD17B2, HTR5A, KDR, PIM1, POLB, PPARA, SIGMAR1, SRC, TYR 2.5733
[BP] GO:0030003 cellular cation homeostasis ADRA1A, CA2, CA7, DRD1, DRD2, DRD3, GRM1, GRM5, HTR2A, HTR2B 2.54629
[BP] GO:0014821 None DRD1, DRD2, HTR2B 2.54629
[BP] GO:0031348 negative regulation of defense response ADORA1, CNR2, CYP19A1, DRD2, MMP12, PPARA 2.54301
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, CYP19A1, CYP1B1, DRD1, DRD2, F10, F3, IGF1R, KDR, MET, SRC 2.53549
[BP] GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation ADORA1, FLT3, GRM5, HTR2A, PTPN1, SRC 2.52559
[BP] GO:0099566 None GRM1, GRM5 2.52559
[BP] GO:0060160 None DRD2, DRD3 2.52559
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.52559
[BP] GO:0033602 None CNR1, DRD2 2.52559
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.50792
[BP] GO:0045187 None ADORA1, DRD2, DRD3 2.49291
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6 2.48634
[BP] GO:0006873 cellular ion homeostasis ADRA1A, CA2, CA7, DRD1, DRD2, DRD3, GRM1, GRM5, HTR2A, HTR2B 2.48062
[BP] GO:0031623 None ACHE, DRD2, DRD3, HTR2B 2.45464
[BP] GO:0032922 None DRD2, DRD3, PPARA, TOP1 2.45464
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, FLT3, GRM1, HTR2A, HTR2B, PTPN1, SRC 2.45374
[BP] GO:0003012 None ADORA1, ADRA1A, DRD1, DRD2, HTR2A, HTR2B, HTR7 2.45374
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ADRA1A, CDC25B, DRD2, FLT3, GRM1, GRM5, HTR2A, HTR2B, KDR, PTPN1, SRC, XDH 2.4398
[BP] GO:0035813 None ADORA1, DRD2, DRD3 2.4398
[BP] GO:0043549 regulation of kinase activity ADORA1, CDC25B, DRD2, FABP4, FLT3, GRM1, GRM5, HTR2A, HTR2B, IGF1R, PTPN1, SRC 2.43957
[BP] GO:0009966 regulation of signal transduction ADORA1, ADRA1A, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, DRD2, DRD3, F10, F3, FLT3, GRM1, HTR2A, HTR2B, HTR6, IGF1R, KDR, MET, MMP12, PTPN1, SRC, TNKS, TNKS2, XDH 2.43777
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 2.40523
[BP] GO:0090066 None ADORA1, ADRA1A, CHRM1, DRD1, HTR1A, HTR2A, HTR2B, HTR7 2.40097
[BP] GO:0016310 phosphorylation AURKB, AXL, CDC25B, CSNK2A1, DRD1, FLT3, HTR2B, IGF1R, KDR, MET, PIM1, SRC, TNKS, TOP1 2.3869
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, SRC 2.3869
[BP] GO:0042749 None ADORA1, DRD2, DRD3 2.3869
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.3869
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ADRA1A, DRD2, HTR2A, HTR2B, KDR, PTPN1, SRC 2.37352
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, HTR2B, IGF1R, KDR, MET, PIM1, PTPN1, SRC 2.35813
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, SRC 2.35411
[BP] GO:0030814 None DRD1, DRD2, DRD3, GRM3, GRM8 2.35343
[BP] GO:0032496 response to lipopolysaccharide ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, SRC 2.35077
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.33833
[BP] GO:0032102 negative regulation of response to external stimulus ADORA1, CNR2, CYP19A1, DRD1, DRD2, DRD3, PPARA 2.3339
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ADRA1A, AURKB, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, F3, FLT3, GRM1, GRM5, HTR2A, HTR2B, IGF1R, KDR, MET, MMP12, PPARA, PTPN1, SRC, TNKS, TNKS2, XDH 2.32796
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, CSNK2A1, DRD1, F10, FLT3, IGF1R, KDR, MET, SRC, TNKS, TOP1 2.32636
[BP] GO:0006874 cellular calcium ion homeostasis ADRA1A, DRD1, DRD2, DRD3, GRM1, GRM5, HTR2A, HTR2B 2.32601
[BP] GO:0051047 None ACHE, ADORA1, CYP19A1, DRD2, DRD3, HTR2B, MMP12, SRC 2.31964
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD17B1, HSD17B2 2.31964
[BP] GO:0030802 None DRD1, DRD2, DRD3, GRM3, GRM8 2.31436
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ADRA1A, AURKB, CA9, CDC25B, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, F3, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, IGF1R, KDR, MET, MMP12, PIM1, POLA1, PPARA, PTPN1, SRC, TNKS, TNKS2, TOP1, XDH 2.31224
[BP] GO:0051953 None ADORA1, CNR1, DRD2 2.29884
[BP] GO:0095500 None CHRM1, CHRM2, CHRM4 2.29884
[BP] GO:0044062 None ADORA1, DRD2, DRD3 2.29884
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.29884
[BP] GO:1903831 None CHRM1, CHRM2, CHRM4 2.29884
[BP] GO:0051480 regulation of cytosolic calcium ion concentration ADRA1A, DRD1, DRD2, GRM1, GRM5, HTR2A, HTR2B 2.29884
[BP] GO:0070213 None TNKS, TNKS2 2.29884
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.29884
[BP] GO:0038171 None CNR1, CNR2 2.29884
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.29884
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade ADRA1A, DRD2, HTR2A, HTR2B, KDR, SRC 2.28808
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, CYP19A1, CYP1B1, DRD1, DRD2, F10, F3, IGF1R, KDR, MET, SRC 2.27689
[BP] GO:0055080 cation homeostasis ADRA1A, CA2, CA7, DRD1, DRD2, DRD3, GRM1, GRM5, HTR2A, HTR2B 2.26268
[BP] GO:2000573 positive regulation of DNA biosynthetic process AURKB, SRC, TNKS, TNKS2 2.26268
[BP] GO:0060402 None ADRA1A, DRD2, HTR2A, HTR2B 2.26268
[BP] GO:0055074 calcium ion homeostasis ADRA1A, DRD1, DRD2, DRD3, GRM1, GRM5, HTR2A, HTR2B 2.26118
[BP] GO:0007202 None ADRA1A, HTR2A, HTR2B 2.25608
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.25608
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6 2.24262
[BP] GO:0006940 None ADORA1, ADRA1A, CHRM1, CHRM2 2.24262
[BP] GO:0072503 cellular divalent inorganic cation homeostasis ADRA1A, DRD1, DRD2, DRD3, GRM1, GRM5, HTR2A, HTR2B 2.2294
[BP] GO:0051240 positive regulation of multicellular organismal process ADRA1A, AXL, CA2, CNR1, CYP1B1, DRD2, DRD3, F3, HTR2A, HTR2B, KDR, MET, MMP12, PIM1, SLC1A1, SRC 2.21778
[BP] GO:0050878 regulation of body fluid levels ADORA1, AKR1B1, CHRM1, DRD2, F10, F3, MET, XDH 2.21778
[BP] GO:0002237 response to molecule of bacterial origin ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, SRC 2.21778
[BP] GO:0015908 None DRD2, DRD3, FABP3, PPARA 2.19735
[BP] GO:1900371 None DRD1, DRD2, DRD3, GRM3, GRM8 2.18584
[BP] GO:0032465 None AURKB, CDC25B, DRD2, DRD3 2.17468
[BP] GO:0030808 None DRD1, DRD2, DRD3, GRM3, GRM8 2.17249
[BP] GO:0035235 None GRIA2, GRIA4, GRIK5 2.16451
[BP] GO:1904353 regulation of telomere capping AURKB, TNKS, TNKS2 2.16451
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ADRA1A, AURKB, CDC25B, DRD1, DRD2, DRD3, F3, FABP3, FLT3, GRM1, GRM5, HTR2A, HTR2B, IGF1R, KDR, MET, MMP12, PPARA, PTPN1, SRC, TNKS, TNKS2, XDH 2.15833
[BP] GO:0060079 None ADORA1, GRIA2, GRIA4, GRIK5 2.15605
[BP] GO:0006936 None ADRA1A, DRD1, DRD2, HTR2A, HTR2B, HTR7 2.12176
[BP] GO:1904357 None SRC, TNKS, TNKS2 2.12176
[BP] GO:0007271 None CHRM1, CHRM2, CHRM4 2.12176
[BP] GO:0021853 None DRD1, DRD2 2.11882
[BP] GO:0010641 None F3, SRC 2.11882
[BP] GO:0090325 None DRD2, DRD3 2.11882
[BP] GO:0007598 None F10, F3 2.11882
[BP] GO:1904936 None DRD1, DRD2 2.11882
[BP] GO:0042321 None ADORA1, DRD2 2.11882
[BP] GO:0010513 None HTR2A, HTR2B 2.11882
[BP] GO:0072507 divalent inorganic cation homeostasis ADRA1A, DRD1, DRD2, DRD3, GRM1, GRM5, HTR2A, HTR2B 2.11042
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ADRA1A, AXL, CA2, CHRM1, CHRM2, CNR1, CYP1B1, DRD2, DRD3, F3, GRM1, HTR2A, HTR2B, KDR, MET, MMP12, PIM1, SLC1A1, SRC, TNKS2, XDH 2.10856
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AURKB, AXL, CDC25B, CHRM1, CSNK2A1, CYP1A1, CYP1A2, CYP2D6, DRD1, DRD2, DRD3, F10, F3, FLT3, FUT7, HTR1A, HTR2B, IGF1R, KDR, MET, MMP12, PIM1, POLB, PPARA, PTPN1, SRC, TNKS, TNKS2, TOP1, TYR, XDH 2.10637
[BP] GO:0007623 circadian rhythm DRD2, DRD3, HTR7, PPARA, TOP1 2.10424
[BP] GO:0007189 None ADRA1A, DRD1, DRD2, DRD3 2.10424
[BP] GO:0046320 None CNR1, FABP3, PPARA 2.09135
[BP] GO:0042417 None DRD1, DRD2, DRD3 2.09135
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, ADRA1A, AURKB, CDC25B, DRD2, F3, FLT3, GRM1, GRM5, HTR2A, HTR2B, PTPN1, SRC, TNKS, XDH 2.07252
[BP] GO:0030534 None DRD1, DRD2, DRD3, HTR2A, PPARA 2.05098
[BP] GO:0090087 None ACHE, ADORA1, CA2, CHRM1, CNR1, DRD2, DRD3, HTR2B, MMP12, PTPN1, SRC 2.05034
[BP] GO:0043271 negative regulation of ion transport ADORA1, CNR1, DRD2, DRD3, HTR2A 2.0388
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ADRA1A, AURKB, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, F3, FABP3, FLT3, GRM1, GRM5, HTR2A, HTR2B, IGF1R, KDR, MET, MMP12, PPARA, PTPN1, SRC, TNKS, TNKS2, XDH 2.02916
[BP] GO:0030799 None DRD1, DRD2, DRD3, GRM3, GRM8 2.02673
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, AXL, CA2, CHRM1, CYP19A1, DRD1, DRD2, DRD3, HTR2B, MMP12, SRC 2.0247
[BP] GO:0060401 None ADRA1A, DRD2, HTR2A, HTR2B 2.02454
[BP] GO:0051302 None AURKB, CDC25B, DRD2, DRD3, HTR2B 2.01588
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, AURKB, AXL, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, FABP3, FABP4, GRM3, GRM8, HTR2A, HTR2B, IGF1R, KDR, MET, MMP12, PIM1, PPARA, PTPN1, SRC, TNKS, TNKS2, XDH 2.00562
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, ADRA1A, AXL, CA4, CHRM1, CHRM2, CHRM4, CNR1, CNR2, DRD1, DRD2, DRD3, F10, F3, FLT3, GRIA2, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, SIGMAR1, SLC1A1 13.7865
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, ADRA1A, AXL, CHRM1, CHRM2, CHRM4, CNR1, CNR2, DRD1, DRD2, DRD3, FLT3, GRIA2, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, SIGMAR1, SLC1A1 11.566
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, ADRA1A, AXL, CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, CNR1, CNR2, DRD1, DRD2, DRD3, F10, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, SIGMAR1, SLC1A1, SRC 10.8758
[CC] GO:0098590 plasma membrane region ADORA1, ADRA1A, CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, CNR1, DRD1, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR2A, MET, SIGMAR1, SLC1A1, SRC 9.65809
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ADRA1A, ALPL, AXL, CA12, CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, DRD1, DRD2, DRD3, F10, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, PIM1, PTPN1, SLC1A1, SRC 7.81851
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, ADRA1A, ALPL, AXL, CA12, CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, F10, F3, FLT3, FUT7, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSD17B2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, MPEG1, PTPN1, SIGMAR1, SLC1A1, SRC, TBXAS1, TYR 7.41295
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ADRA1A, ALOX5, ALPL, AXL, CA12, CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, F10, F3, FLT3, FUT7, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSD17B2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, PIM1, PTPN1, SIGMAR1, SLC1A1, SRC, TBXAS1, TNKS, TNKS2, TYR 7.26944
[CC] GO:0097060 None CHRM1, CHRM2, CHRM4, CNR1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, SIGMAR1 6.74479
[CC] GO:0043005 None ADORA1, CA2, CHRM1, CHRM2, CNR1, CNR2, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR2B, HTR5A, SRC 6.0826
[CC] GO:0044456 None ACHE, ADORA1, CHRM1, CHRM2, CHRM4, CNR1, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, SIGMAR1, SRC 6.02862
[CC] GO:0042995 cell projection ADORA1, AKR1B1, CA2, CHRM1, CHRM2, CNR1, CNR2, DRD1, DRD2, DRD3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR2B, HTR5A, HTR6, SRC 5.5006
[CC] GO:0120025 None ADORA1, AKR1B1, CA2, CHRM1, CHRM2, CNR1, CNR2, DRD1, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR2B, HTR5A, HTR6, SRC 5.1955
[CC] GO:0031224 None ACHE, ADORA1, ADORA3, ADRA1A, ALPL, AXL, CA12, CA4, CA9, CHRM1, CHRM2, CHRM4, CNR1, CNR2, DRD1, DRD2, DRD3, F10, F3, FLT3, FUT7, GRIA2, GRM1, GRM3, GRM5, GRM8, HSD17B2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, MPEG1, SIGMAR1, SLC1A1, TBXAS1, TYR 5.07457
[CC] GO:0014069 None ADORA1, CHRM1, DRD2, GRIK5, GRM1, GRM3, GRM5, SIGMAR1, SRC 5.01984
[CC] GO:0099572 None ADORA1, CHRM1, DRD2, GRIK5, GRM1, GRM3, GRM5, SIGMAR1, SRC 5.01984
[CC] GO:0097458 None ADORA1, CA2, CHRM1, CHRM2, CNR1, CNR2, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR2A, HTR2B, HTR5A, SIGMAR1, SRC, TOP1 4.79708
[CC] GO:0042734 None CNR1, GRIK5, GRM1, GRM3, GRM5, GRM8 4.67832
[CC] GO:0016021 None ADORA1, ADORA3, ADRA1A, ALPL, AXL, CA12, CA9, CHRM1, CHRM2, CHRM4, CNR1, CNR2, DRD1, DRD2, DRD3, F3, FLT3, FUT7, GRIA2, GRM1, GRM3, GRM5, GRM8, HSD17B2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, MPEG1, SIGMAR1, SLC1A1, TBXAS1, TYR 3.92387
[CC] GO:0044463 None ADORA1, AKR1B1, CA4, CA9, CHRM1, CHRM2, CNR1, DRD1, DRD2, GRIA2, GRIA4, GRIK5, GRM3, HTR2A, SIGMAR1, SRC 3.85569
[CC] GO:0120038 None ADORA1, AKR1B1, CA4, CA9, CHRM1, CHRM2, CNR1, DRD1, DRD2, GRIA2, GRIA4, GRIK5, GRM3, HTR2A, SIGMAR1, SRC 3.85569
[CC] GO:0045211 None CHRM1, CHRM2, CHRM4, GRIA2, GRIA4, GRIK5, GRM3, SIGMAR1 3.8454
[CC] GO:0030425 None CHRM1, CHRM2, CNR2, DRD2, GRIA2, GRIK5, GRM1, HTR5A 2.63902
[CC] GO:0031233 None CA4, F10, F3 2.4398
[CC] GO:0043204 None CNR2, DRD2, GRIK5, HTR5A, TOP1 2.36715
[CC] GO:0043197 None ADORA1, DRD2, GRIA2, GRIA4, GRM3 2.32636
[CC] GO:0044309 None ADORA1, DRD2, GRIA2, GRIA4, GRM3 2.29978
[MF] GO:0030594 None CHRM1, CHRM2, CHRM4, DRD1, DRD2, DRD3, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 18.6624
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, ADRA1A, AXL, CHRM1, CHRM2, CHRM4, CNR1, CNR2, DRD1, DRD2, DRD3, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, SIGMAR1 14.576
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, ADRA1A, AXL, CHRM1, CHRM2, CHRM4, CNR1, CNR2, DRD1, DRD2, DRD3, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, SIGMAR1 14.576
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, ADRA1A, AXL, CHRM1, CHRM2, CHRM4, CNR1, CNR2, DRD1, DRD2, DRD3, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, PPARA, SIGMAR1 14.5726
[MF] GO:0004872 receptor activity ADORA1, ADORA3, ADRA1A, AXL, CHRM1, CHRM2, CHRM4, CNR1, CNR2, DRD1, DRD2, DRD3, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, PPARA, SIGMAR1 13.1787
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, ADRA1A, AXL, CHRM1, CHRM2, CHRM4, CNR1, CNR2, DRD1, DRD2, DRD3, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, PPARA, SIGMAR1 12.8208
[MF] GO:0008227 None ADRA1A, CHRM1, CHRM2, CHRM4, DRD2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 12.7388
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, ADRA1A, AXL, CHRM1, CHRM2, CHRM4, CNR1, CNR2, DRD1, DRD2, DRD3, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, PPARA, SIGMAR1 12.0626
[MF] GO:0099528 None CHRM1, CHRM2, CHRM4, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 10.964
[MF] GO:0004930 None ADORA1, ADORA3, ADRA1A, CHRM1, CHRM2, CHRM4, CNR1, CNR2, DRD1, DRD2, DRD3, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, SIGMAR1 9.68632
[MF] GO:0008066 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 8.385
[MF] GO:0070405 ammonium ion binding ACHE, DRD1, DRD2, DRD3, HTR1A, HTR2A, HTR2B, HTR5A, HTR7 8.385
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CHRM1, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, FLT3, HTR2A, HTR2B, IGF1R, KDR, MET, PIM1, PPARA, SIGMAR1, SRC, TOP1 7.26944
[MF] GO:0004993 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 7.01143
[MF] GO:0099589 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 7.01143
[MF] GO:0043176 None HTR1A, HTR2A, HTR2B, HTR5A, HTR7 7.0044
[MF] GO:0051378 None HTR1A, HTR2A, HTR2B, HTR5A, HTR7 7.0044
[MF] GO:0043167 ion binding ACHE, ALOX5, ALPL, AURKB, AXL, CA12, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, F10, F3, FABP3, FABP4, FLT3, HSD17B1, HTR1A, HTR2A, HTR2B, HTR5A, HTR7, IGF1R, KDR, MET, MMP12, PIM1, POLA1, POLB, PPARA, PTPN1, SLC1A1, SRC, TBXAS1, TNKS, TNKS2, TOP1, TYR, XDH 6.29438
[MF] GO:0004089 carbonate dehydratase activity CA12, CA2, CA4, CA7, CA9 6.24212
[MF] GO:0046914 transition metal ion binding ALOX5, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, MMP12, PIM1, PPARA, PTPN1, TBXAS1, TNKS, TYR, XDH 5.80542
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6 5.30512
[MF] GO:0042165 neurotransmitter binding ACHE, HTR1A, HTR2A, HTR2B, HTR5A, HTR7 5.07457
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6 5.06626
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, TBXAS1, TYR 4.9162
[MF] GO:0005506 iron ion binding ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, TBXAS1, XDH 4.60685
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, AURKB, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, F10, HTR1A, HTR2A, HTR2B, HTR5A, HTR7, MMP12, PIM1, POLA1, POLB, PPARA, PTPN1, SLC1A1, TBXAS1, TNKS, TNKS2, TYR, XDH 4.35227
[MF] GO:0016835 carbon-oxygen lyase activity CA12, CA2, CA4, CA7, CA9, POLB 4.23267
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, SRC, TBXAS1 4.12469
[MF] GO:0016907 None CHRM1, CHRM2, CHRM4 4.09157
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6 4.00169
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AURKB, AXL, CA12, CA2, CA4, CA7, CA9, CDC25B, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, F10, F3, FLT3, FUT7, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP12, PIM1, POLA1, POLB, PTPN1, SRC, TBXAS1, TNKS, TNKS2, TOP1, TYR, XDH 3.96465
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, SRC, TBXAS1 3.95217
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, TBXAS1, TYR 3.66268
[MF] GO:0016836 hydro-lyase activity CA12, CA2, CA4, CA7, CA9 3.62782
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, HSD17B1, HSD17B2, TBXAS1, TYR, XDH 3.57131
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.41053
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, HSD17B1, POLA1, SRC, TBXAS1, XDH 3.01684
[MF] GO:0004952 None DRD1, DRD2, DRD3 2.987
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 2.98463
[MF] GO:0035240 None DRD1, DRD2, DRD3 2.89467
[MF] GO:0015464 None CHRM1, CHRM2, CHRM4 2.54629
[MF] GO:0004949 None CNR1, CNR2 2.52559
[MF] GO:0099583 None GRM1, GRM5 2.52559
[MF] GO:0004970 None GRIA2, GRIA4, GRIK5 2.49291
[MF] GO:0005234 None GRIA2, GRIA4, GRIK5 2.49291
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, SRC 2.4398
[MF] GO:1901338 None DRD1, DRD2, DRD3 2.4398
[MF] GO:0016829 lyase activity CA12, CA2, CA4, CA7, CA9, POLB 2.40523
[MF] GO:0004971 None GRIA2, GRIA4 2.29884
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, SRC, TOP1 2.14657
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, HSD17B1, HSD17B2, XDH 2.10424


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, GRIA2, CHRM1, CHRM4, GRIK5, HTR2B, HTR1A, HTR2A, HTR5A, ADRA1A, GRM1, GRM3, HTR6, GRM5, HTR7, CNR2, CNR1, ADORA3, GRM8, ADORA1, DRD1, DRD2, DRD3, GRIA4 24.6269
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, HTR6, GRM5, HTR7, CHRM1, HTR2B, HTR2A, DRD1, HTR5A, ADRA1A, GRM1 8.6853
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 7.7375
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, GRIA2, HTR6, CHRM1, ADORA1, HTR1A, DRD1, DRD2, PPARA, GRIA4 7.2317
Glutamatergic synapse_Homo sapiens_hsa04724 GRM3, GRIA2, GRM5, GRIK5, GRM8, SLC1A1, GRM1, GRIA4 6.9416
Serotonergic synapse_Homo sapiens_hsa04726 HTR6, HTR7, CYP2D6, ALOX5, HTR2B, HTR1A, HTR2A, HTR5A 6.9416
Gap junction_Homo sapiens_hsa04540 GRM5, SRC, HTR2B, HTR2A, DRD1, DRD2, GRM1 6.4058
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 6.1227
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA2, CA4, CA7, CA9 7.1472
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MET, IGF1R 4.0997
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 GRIA2, GRM5, CNR1, GRM1, GRIA4 3.5188
Metabolic pathways_Homo sapiens_hsa01100 AKR1B1, TYR, CYP19A1, POLA1, FUT7, AKR1B10, ALOX5, HSD17B1, TBXAS1, HSD17B2, CYP1A2, CYP1A1, ALPL, XDH 3.0777
Cocaine addiction_Homo sapiens_hsa05030 GRM3, GRIA2, DRD1, DRD2 3.5188
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, CNR1, KDR, DRD2, MET, IGF1R 3.0767
Dopaminergic synapse_Homo sapiens_hsa04728 GRIA2, DRD1, DRD2, DRD3, GRIA4 3.0777
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CYP2D6, CYP1A2, CYP1A1, CYP1B1 3.0169
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, CHRM1, CHRM4 2.3679
Phospholipase D signaling pathway_Homo sapiens_hsa04072 GRM3, GRM5, GRM8, GRM1 2.0203
Long-term depression_Homo sapiens_hsa04730 GRIA2, GRM1, IGF1R 2.0981
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1 2.5701
Amphetamine addiction_Homo sapiens_hsa05031 GRIA2, DRD1, GRIA4 2.0203
Long-term potentiation_Homo sapiens_hsa04720 GRIA2, GRM5, GRM1 2.0203
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC, HTR2B, HTR2A 1.637
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, KDR, MET, IGF1R 1.6254
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, MET, IGF1R 1.6254
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, CHRM1, KDR, MET, IGF1R 1.5664
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, PPARA 2.002
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, CHRM1, SRC, CHRM4 1.5664
Chemical carcinogenesis_Homo sapiens_hsa05204 CYP1A2, CYP1A1, CYP1B1 1.823
Ras signaling pathway_Homo sapiens_hsa04014 HTR7, KDR, MET, IGF1R 1.5099
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.3395
MicroRNAs in cancer_Homo sapiens_hsa05206 PIM1, CYP1B1, MET, CDC25B 1.2083
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1, ADRA1A 1.2078
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MET, IGF1R 1.1719
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1 1.246
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.2427
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.2089
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.2254
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET 1.1826
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 0.9658
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 PIM1, F3 0.9646
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 0.8542
Circadian entrainment_Homo sapiens_hsa04713 GRIA2, GRIA4 0.9821
Taste transduction_Homo sapiens_hsa04742 HTR1A, GRM1 1.0723
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, TBXAS1 1.2083
Melanoma_Homo sapiens_hsa05218 MET, IGF1R 1.1719
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, GRM1 0.9658
Morphine addiction_Homo sapiens_hsa05032 ADORA1, DRD1 1.0077
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.1799
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1 1.1976
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PPARA 0.9133
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.105
Platelet activation_Homo sapiens_hsa04611 SRC, TBXAS1 0.8486
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2D6, CYP1A2 1.1772
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, ADORA1 0.8542
Complement and coagulation cascades_Homo sapiens_hsa04610 F10, F3 1.1033
FoxO signaling pathway_Homo sapiens_hsa04068 GRM1, IGF1R 0.7972
AMPK signaling pathway_Homo sapiens_hsa04152 ADRA1A, IGF1R 0.8431
Parkinson's disease_Homo sapiens_hsa05012 DRD1, DRD2 0.7683
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.7711
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.637
Purine metabolism_Homo sapiens_hsa00230 POLA1, XDH 0.656
Alcoholism_Homo sapiens_hsa05034 DRD1, DRD2 0.6499
Pathways in cancer_Homo sapiens_hsa05200 FLT3, MET, IGF1R 0.5819
Viral carcinogenesis_Homo sapiens_hsa05203 POLB, SRC 0.5819
Nicotine addiction_Homo sapiens_hsa05033 GRIA2, GRIA4 1.5022
HTLV-I infection_Homo sapiens_hsa05166 POLB 0.2235
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.2235
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1 0.2864
Huntington's disease_Homo sapiens_hsa05016 GRM5 0.2968
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.303
Tuberculosis_Homo sapiens_hsa05152 SRC 0.3115
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.6254
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.303
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1 0.3461
Hepatitis B_Homo sapiens_hsa05161 SRC 0.3579
Measles_Homo sapiens_hsa05162 CSNK2A1 0.3671
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 IGF1R 0.3636
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1 0.3636
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 ADRA1A 0.357
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.354
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.3636
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC 0.3461
Hepatitis C_Homo sapiens_hsa05160 PPARA 0.371
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.3874
ErbB signaling pathway_Homo sapiens_hsa04012 SRC 0.4455
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC 0.3931
Cell cycle_Homo sapiens_hsa04110 CDC25B 0.3874
Axon guidance_Homo sapiens_hsa04360 MET 0.383
Vascular smooth muscle contraction_Homo sapiens_hsa04270 ADRA1A 0.3912
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5 0.3931
Prostate cancer_Homo sapiens_hsa05215 IGF1R 0.4455
HIF-1 signaling pathway_Homo sapiens_hsa04066 IGF1R 0.4296
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.823
Melanogenesis_Homo sapiens_hsa04916 TYR 0.4326
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4326
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.4455
GnRH signaling pathway_Homo sapiens_hsa04912 SRC 0.4455
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.4455
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.4429
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.5664
Pyrimidine metabolism_Homo sapiens_hsa00240 POLA1 0.4267
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4429
Salivary secretion_Homo sapiens_hsa04970 ADRA1A 0.4455
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1 0.4429
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4455
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4429
Peroxisome_Homo sapiens_hsa04146 XDH 0.4455
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC 0.4878
Protein digestion and absorption_Homo sapiens_hsa04974 SLC1A1 0.4455
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.4821
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.4888
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.5074
Bile secretion_Homo sapiens_hsa04976 CA2 0.4883
Glioma_Homo sapiens_hsa05214 IGF1R 0.5074
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5065
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.5074
Shigellosis_Homo sapiens_hsa05131 SRC 0.5074
Malaria_Homo sapiens_hsa05144 MET 0.5819
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 GRIA2 0.5819
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.6014
Bladder cancer_Homo sapiens_hsa05219 SRC 0.6421
Tyrosine metabolism_Homo sapiens_hsa00350 TYR 0.6832
DNA replication_Homo sapiens_hsa03030 POLA1 0.6776
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7208
Base excision repair_Homo sapiens_hsa03410 POLB 0.7014
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.7423
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.7683
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.7655
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 0.9658
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.0169


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)