TCM Prescription: Kai Xiong Li Qi Pills



Prescription Description
Prescription IDTCMFx4836
Pinyin NameKai Xiong Li Qi Wan
Chinese Name开胸理气丸
English NameKai Xiong Li Qi Pills
Function Description悬饮, 积滞, 痢疾
IndicationsDysentery disorder, Pleural fluid retention disorder, Dyspepsia, Dysentery
Disease ICD-11 Category SA56 [Dysentery disorder (TM1), 痢疾 (TM1) ];
SA83 [Pleural fluid retention disorder (TM1), 悬饮 (TM1) ];
MD92 [Dyspepsia, 消化不良 ];
1A40.Z [Infectious gastroenteritis or colitis without specification of infectious agent, 未特指感染性病原体的感染性胃肠炎或结肠炎 ];
Human Tissues Associated with IndicationSpleen, Intestine, Stomach
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1533 Saussurea lappa 木香 TCMH1533
TCMH243 Pericarpium citri reticulatae 陈皮 TCMH243
TCMH890 Cortex magnoliae officinalis 厚朴 TCMH890 ITSAM1591-14
TCMH1766 Sparganium stoloniferum 三棱 TCMH1766 ITSAJ4240-14
TCMH544 Curcuma aeruginosa 莪术 TCMH544 ITSAN2146-14
TCMH1662 Pharbitis nil 牵牛子 TCMH1662
TCMH1072 Semen arecae preparata 焦槟榔 TCMH1072 ITSAA732-14
TCMH2693 Fructus gleditsiae abnormalis 猪牙皂 TCMH2693
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT114 CNR2 Cannabinoid CB2 receptor GPCR P34972
TCMT115 CNR1 Cannabinoid CB1 receptor GPCR P21554
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT292 CHRM1 Muscarinic acetylcholine receptor M1 GPCR P11229
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT551 CHRM4 Muscarinic acetylcholine receptor M4 GPCR P08173
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT678 XIAP Inhibitor of apoptosis protein 3 Transferase P98170
TCMT679 MPEG1 Macrophage-expressed gene 1 protein Unclassified Q2M385
TCMT680 KAT2B Histone acetyltransferase PCAF Transferase Q92831


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1178 Actinomyces viscosus
TCMT1180 Human herpesvirus 2
TCMT1183 Candida albicans SC5314
TCMT1201 Staphylococcus epidermidis ATCC 12228
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1221 Human herpesvirus 4
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1284 Penicillium expansum
TCMT1285 Human coxsackievirus B3
TCMT1286 Bacillus cereus
TCMT1318 Human T-lymphotropic virus 1
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1370 Prevotella melaninogenica
TCMT1438 Plasmodium falciparum
TCMT1448 Enterobacter aerogenes
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway