TCM Prescription: Gu Xian Tablet



Prescription Description
Prescription IDTCMF745
Pinyin NameGu Xian Pian 
Chinese Name骨仙片
English NameGu Xian Tablet
Function Description痹病
IndicationsArthritis, Rheumatoid arthritis
Disease ICD-11 Category FA2Z [Inflammatory arthropathies, unspecified, 炎性关节病，未特指的 ];
FA20 [Rheumatoid arthritis, 类风湿性关节炎 ];
Human Tissues Associated with IndicationSkeletalMuscle, Blood
ReferenceChinese pharmacopoeia (2015)
Reference Book/linkISBN 978-7-5067-7337-9
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1966 Rehmannia glutinosa 熟地黄 TCMH1966 ITSAH4578-14
TCMH1186 Lycium chinense 枸杞子 TCMH1186 ITSAO4545-14
TCMH1597 Ligustrum lucidum 女贞子 TCMH1597 ITSAM2109-14
TCMH834 Semen glycine max 黑豆 TCMH834 ITSAJ4675-14
TCMH2149 Cuscuta australis 菟丝子 TCMH2149 ITSAP4209-14
TCMH700 Drynaria fortunei 骨碎补 TCMH700 GBVM3977-11
TCMH2256 Curculigo orchioides 仙茅 TCMH2256 GENG778-14
TCMH1588 Achyranthes bidentata 牛膝 TCMH1588 ITSAJ4612-14
TCMH565 Stephania tetrandra 防己 TCMH565 ITSAG893-14
Reference: Chinese pharmacopoeia (2015)

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT107 GRIK2 Glutamate receptor ionotropic kainate 2 Ion channel Q13002
TCMT109 GRIA2 Glutamate receptor ionotropic, AMPA 2 Ion channel P42262
TCMT110 GRIA4 Glutamate receptor ionotropic, AMPA 4 Ion channel P48058
TCMT111 GRIK5 Glutamate receptor ionotropic kainate 5 Ion channel Q16478
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT187 AR Androgen Receptor Nuclear receptor P10275
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT290 CHRM5 Muscarinic acetylcholine receptor M5 GPCR P08912
TCMT291 CHRM3 Muscarinic acetylcholine receptor M3 GPCR P20309
TCMT292 CHRM1 Muscarinic acetylcholine receptor M1 GPCR P11229
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT653 GRM1 Metabotropic glutamate receptor 1 GPCR Q13255
TCMT654 GRM5 Metabotropic glutamate receptor 5 GPCR P41594
TCMT655 GRM2 Metabotropic glutamate receptor 2 GPCR Q14416
TCMT656 GRM3 Metabotropic glutamate receptor 3 GPCR Q14832
TCMT657 GRM4 Metabotropic glutamate receptor 4 GPCR Q14833
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT660 GRM8 Metabotropic glutamate receptor 8 GPCR O00222
TCMT664 SLC1A1 Excitatory amino acid transporter 3 Transporter P43005
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718
TCMT974 GPER1 G-protein coupled estrogen receptor 1 GPCR Q99527
TCMT99 SHBG Testis-specific androgen-binding protein Unclassified P04278


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1180 Human herpesvirus 2
TCMT1189 Pseudomonas fluorescens
TCMT1191 Bacillus megaterium
TCMT1208 Escherichia coli K12
TCMT1212 Verticillium dahliae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1217 Bacillus anthracis
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1236 Mycobacterium bovis
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1260 Streptococcus agalactiae
TCMT1286 Bacillus cereus
TCMT1293 Vaccinia virus
TCMT1294 Human parainfluenza virus 3
TCMT1319 Corynebacterium xerosis
TCMT1322 Streptococcus mitis
TCMT1323 Corynebacterium pseudodiphtheriticum
TCMT1324 Corynebacterium diphtheriae
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1390 Human herpesvirus 2 strain G
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APP, AR, AXL, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, GPER1, GRIK5, GRM5, HSD17B2, IGF1R, MMP2, MMP9, PPARA, RORC, SRC, TYR 8.50868
[BP] GO:0007215 None APP, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 8.39212
[BP] GO:0007193 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, GRM1, GRM3, GRM5, GRM8 8.16821
[BP] GO:0010033 response to organic substance AKR1B1, ALPL, APP, AR, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, GPER1, GRIK5, GRM5, HSD17B2, IGF1R, KDR, MMP2, PPARA, RORC, SRC, TYR 7.23644
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, APP, AR, AURKB, AXL, CA12, CA2, CA7, CHRM1, CHRM3, CYP19A1, CYP1A1, CYP1B1, ESR1, FABP3, FABP4, FLT3, GPER1, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HCAR2, HSD17B1, HSD17B2, KDR, MET, PPARA, SLC1A1, SRC, XDH 6.95588
[BP] GO:0007188 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, GPER1, GRM1, GRM3, GRM5, GRM8 6.95353
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.9042
[BP] GO:0033993 response to lipid ALPL, AR, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, GPER1, HSD17B2, RORC, SRC, TYR 6.88375
[BP] GO:0030522 intracellular receptor signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, GPER1, PIM1, PPARA, RORC, SRC 6.5678
[BP] GO:0043401 steroid hormone mediated signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, GPER1, PPARA, RORC, SRC 6.4137
[BP] GO:0007187 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, GPER1, GRM1, GRM3, GRM5, GRM8 6.4137
[BP] GO:0007197 None CHRM1, CHRM2, CHRM3, CHRM5 6.36105
[BP] GO:0042221 response to chemical AKR1B1, ALPL, APP, AR, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, GPER1, GRIK5, GRM5, HSD17B2, IGF1R, KDR, MMP2, MMP9, PPARA, RORC, SRC, TYR 6.15542
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APP, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FUT7, HSD17B1, HSD17B2, MET, PPARA 6.15542
[BP] GO:0014070 response to organic cyclic compound ALPL, APP, AR, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FLT3, GPER1, RORC, SRC, TYR 6.08544
[BP] GO:0007207 None CHRM1, CHRM2, CHRM3, CHRM5 5.97988
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APP, AR, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, GPER1, GRM5, IGF1R, MMP2, PPARA, SRC 5.95527
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 5.95527
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, APP, CA2, CA7, GPER1, GRIK5, GRM1, GRM3, GRM5, GRM8 5.67454
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, APP, CA2, CA7, GPER1, GRIK5, GRM1, GRM3, GRM5, GRM8 5.67454
[BP] GO:0009755 hormone-mediated signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, GPER1, PPARA, RORC, SRC 5.67454
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, APP, AR, AXL, CHRM1, CHRM3, CHRM5, CYP19A1, CYP1A2, CYP1B1, ESR1, ESRRB, FABP4, GPER1, GRM1, GRM5, GRM8, HSD17B2, IGF1R, MET, MMP1, MMP2, MMP9, PIM1, PPARA, RORC, SRC, TYR 5.5911
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, APP, AR, AXL, CA1, CA2, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPER1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SRC 5.56899
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, APP, AR, AURKB, AXL, CA2, CA7, CDC25B, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GPER1, GRIK5, GRM1, GRM5, HCAR2, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SLC1A1, SRC, XDH 5.45259
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, HSD17B1, HSD17B2 5.43714
[BP] GO:0007196 None GRM1, GRM3, GRM5, GRM8 5.23024
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FUT7, PIM1, PPARA, TYR, XDH 5.23024
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, TYR 5.15583
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, APP, AR, AURKB, AXL, CA2, CA7, CDC25B, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, GPER1, GRIK5, GRM1, GRM5, HCAR2, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SRC, XDH 5.09736
[BP] GO:0009725 response to hormone AKR1B1, ALPL, AR, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, GPER1, PPARA, SRC 4.9893
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, APP, AR, CDC25B, CHRM1, CSNK2A1, CYP1B1, ESR1, ESRRA, FABP3, FLT3, GPER1, IGF1R, KDR, MMP2, MMP9, PIM1, SRC, XDH 4.90306
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, GPER1, GRIK5, HCAR2, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, SRC, XDH 4.88776
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALPL, APP, AR, AXL, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, GPER1, GRIK5, GRM5, IGF1R, KDR, MMP2, MMP9, RORC, SRC 4.87818
[BP] GO:0007268 None CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 4.84478
[BP] GO:0098916 None CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 4.84478
[BP] GO:0099536 None CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 4.76233
[BP] GO:0099537 None CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 4.76233
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALPL, APP, AR, AXL, CYP1A1, CYP1B1, ESR1, FABP4, FLT3, GPER1, GRIK5, GRM5, IGF1R, KDR, MMP2, RORC, SRC 4.75925
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, GPER1, GRIK5, HCAR2, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SRC, XDH 4.75317
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.66152
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALPL, APP, AR, AURKB, AXL, CA2, CA9, CBR1, CDC25B, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, HSD17B2, KDR, MET, MMP2, MMP9, PIM1, PPARA, RORC, SRC, TYR 4.55145
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, APP, AR, CDC25B, CHRM5, ESRRB, FABP3, FABP4, FLT3, GPER1, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MMP9, PPARA, PTPN1, SRC, XDH 4.54327
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, APP, AR, CDC25B, CHRM5, ESRRB, FABP3, FABP4, FLT3, GPER1, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MMP9, PPARA, PTPN1, SRC, XDH 4.49004
[BP] GO:0007216 None GRM1, GRM3, GRM5, GRM8 4.49004
[BP] GO:0007267 None ADORA1, AR, CHRM1, CHRM2, CHRM3, CHRM5, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 4.47403
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APP, AR, AXL, CYP1B1, ESR1, GPER1, GRIK5, GRM5, IGF1R, MMP2, MMP9, RORC, SRC 4.4033
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.31147
[BP] GO:0008283 cell proliferation ACHE, AR, AURKB, CHRM1, CHRM3, CHRM5, CYP1A1, ESR1, FLT3, MET, PIM1, SRC, TYR 4.27872
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, APP, AR, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, GPER1, GRM1, HCAR2, KDR, MET, MMP9, PTPN1, SRC, XDH 4.27285
[BP] GO:0007213 None CHRM1, CHRM2, CHRM3, CHRM5 4.27285
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, APP, AR, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, GPER1, GRM1, HCAR2, KDR, MET, MMP9, PTPN1, SRC, XDH 4.25612
[BP] GO:0048513 animal organ development ACHE, AR, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, FLT3, HSD17B2, KDR, PPARA, SRC, TYR 4.25612
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APP, AR, CYP1A1, CYP1B1, ESR1, FLT3, GPER1, RORC, SRC 4.23546
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, APP, AR, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, FLT3, GPER1, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, MMP9, PTPN1, SRC, XDH 4.21286
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, GPER1, GRIK5, HCAR2, IGF1R, KDR, MMP9, PIM1, PTPN1, SRC, XDH 4.21174
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CHRM5, CYP1A1, FABP3, FLT3, GPER1, HCAR2, PPARA, RORC, SRC 4.13655
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, APP, AR, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, FLT3, GPER1, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, MMP9, PTPN1, SRC, XDH 4.13283
[BP] GO:0010035 response to inorganic substance AKR1B1, APP, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, MMP9, SRC 4.13142
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALPL, APP, AR, AXL, CA2, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, FLT3, HSD17B2, KDR, MMP9, PIM1, PPARA, RORC, SRC, TYR 4.12119
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALPL, APP, AR, AURKB, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, GPER1, GRIK5, GRM1, GRM5, IGF1R, KDR, MMP2, MMP9, PTPN1, RORC, SRC 4.05992
[BP] GO:0023052 None ADORA1, AR, CHRM1, CHRM2, CHRM3, CHRM5, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 4.05666
[BP] GO:0007200 None CHRM1, CHRM2, CHRM3, CHRM5, ESR1, GRM5 4.02356
[BP] GO:0007154 None ADORA1, AR, AXL, CHRM1, CHRM2, CHRM3, CHRM5, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 3.79218
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, GPER1, HCAR2, HSD17B1, HSD17B2 3.76967
[BP] GO:0095500 None CHRM1, CHRM2, CHRM3, CHRM5 3.72097
[BP] GO:1903831 None CHRM1, CHRM2, CHRM3, CHRM5 3.72097
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter AR, ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 3.70402
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, SLC1A1 3.66607
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.65896
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, APP, AXL, CA12, CA2, CA7, ESR1, FABP3, FABP4, FLT3, GPER1, GRIK5, GRM1, GRM5, MET, SRC 3.56622
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, GRM1, GRM3, GRM5, GRM8 3.5433
[BP] GO:0035235 None APP, GRIA2, GRIA4, GRIK5 3.53308
[BP] GO:0007271 None CHRM1, CHRM2, CHRM3, CHRM5 3.47108
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, SRC 3.39186
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, APP, AR, CDC25B, ESRRB, FABP3, FLT3, GPER1, GRM1, GRM5, KDR, MMP9, PTPN1, SRC, XDH 3.3715
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, APP, AR, CDC25B, ESRRB, FABP3, FLT3, GPER1, GRM1, GRM5, KDR, MMP9, PTPN1, SRC, XDH 3.3715
[BP] GO:0006940 None ADORA1, CHRM1, CHRM2, CHRM3, GPER1 3.36577
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, APP, AR, AXL, CYP1B1, FLT3, GPER1, GRM1, KDR, MET, PTPN1, SRC, XDH 3.28208
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA1, ADORA3, APP, CA2, CHRM1, CHRM2, CHRM3, CHRM5, ESR1, GPER1, GRM1, GRM3, GRM5, GRM8, HCAR2, SRC 3.2383
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, APP, AXL, CA1, CSNK2A1, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, MMP2, MMP9, PTPN1, SRC 3.2289
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, APP, AR, CDC25B, ESRRB, FLT3, GPER1, GRM1, GRM5, KDR, MMP9, PTPN1, SRC, XDH 3.22579
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC 3.19396
[BP] GO:2001225 regulation of chloride transport CA2, CA7, GRM5 3.16815
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.16815
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, APP, AR, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, GPER1, GRM1, IGF1R, KDR, MET, MMP9, PTPN1, SRC, XDH 3.16815
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SRC 3.1304
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CSNK2A1, CYP1B1, ESR1, FABP4, GRM3, IGF1R, MET, MMP9, PIM1, PPARA, PTPN1, SRC 3.1136
[BP] GO:0006352 DNA-templated transcription, initiation AR, ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 3.08845
[BP] GO:0042325 regulation of phosphorylation ADORA1, APP, AR, CDC25B, ESRRB, FABP4, FLT3, GPER1, GRM1, GRM5, IGF1R, KDR, MMP9, PPARA, PTPN1, SRC, XDH 3.06125
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, AR, CDC25B, CHRM1, CSNK2A1, ESR1, FLT3, GPER1, IGF1R, KDR, MMP2, MMP9, PIM1 3.06052
[BP] GO:0060078 None ADORA1, GRIA2, GRIA4, GRIK5, GRM5 3.05869
[BP] GO:0060736 prostate gland growth AR, CYP19A1, ESR1 3.05869
[BP] GO:0030518 intracellular steroid hormone receptor signaling pathway AR, ESR1, ESR2, GPER1, SRC 3.03545
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, APP, AR, AXL, CA2, CA7, CHRM1, CSNK2A1, CYP19A1, CYP1B1, GPER1, GRIK5, GRM5, HCAR2, IGF1R, KDR, MET, MMP9, PPARA, PTPN1, SRC 3.03472
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, AOX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, HSD17B2, TYR, XDH 3.01801
[BP] GO:0042391 None ADORA1, APP, GPER1, GRIA2, GRIA4, GRIK5, GRM5, KDR, SRC 3.01588
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, APP, AR, FLT3, GPER1, GRM1, KDR, PTPN1, SRC, XDH 3.01588
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, ALPL, APP, AR, AURKB, AXL, CA2, CA9, CHRM2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, GPER1, GRIK5, GRM1, GRM5, HSD17B2, IGF1R, KDR, MMP2, MMP9, PPARA, PTPN1, RORC, SRC, TYR 2.96699
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.85759
[BP] GO:0009115 None AOX1, XDH 2.81585
[BP] GO:0048878 chemical homeostasis AKR1B1, APP, CA12, CA2, CA7, ESR1, FABP3, FABP4, GPER1, GRIK5, GRM1, GRM5, MET 2.80498
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, SLC1A1 2.80076
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, APP, AR, CDC25B, FLT3, GPER1, GRM1, GRM5, KDR, MMP9, PTPN1, SRC, XDH 2.80076
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.77069
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, PIM1, PPARA, PTPN1, RORC, SRC, TYR, XDH 2.76403
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, MET, PPARA 2.72475
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1 2.64001
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GPER1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SLC1A1, SRC, TYR, XDH 2.61489
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AOX1, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, MMP1, MMP2, MMP9, SRC, XDH 2.61489
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.61489
[BP] GO:1901652 response to peptide AKR1B1, APP, FABP3, GPER1, GRM5, IGF1R, PPARA, SRC 2.60875
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, IGF1R, KDR, MMP9, PIM1, PTPN1, SRC 2.5719
[BP] GO:0043408 regulation of MAPK cascade ADORA1, APP, AR, FLT3, GPER1, GRM1, IGF1R, KDR, PTPN1, SRC, XDH 2.56206
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, APP, AR, AXL, CA2, CHRM1, CHRM2, CHRM3, CYP1B1, ESR1, ESRRA, ESRRB, GPER1, GRM1, HCAR2, KDR, MET, MMP9, PIM1, SLC1A1, SRC, XDH 2.5214
[BP] GO:0006690 icosanoid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1 2.51888
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, APP, AR, AXL, CSNK2A1, CYP1B1, FLT3, GPER1, GRM1, KDR, MET, MMP9, PTPN1, SRC, XDH 2.50269
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SRC, TYR, XDH 2.49868
[BP] GO:0010676 None ESRRB, GPER1, PPARA, SRC 2.49446
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, SRC 2.45439
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 2.44222
[BP] GO:0019369 arachidonic acid metabolic process CBR1, CYP1A1, CYP1A2, CYP1B1 2.44108
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APP, CHRM1, CYP19A1, CYP1B1, GPER1, IGF1R, KDR, MET, MMP9, SRC 2.43299
[BP] GO:0099566 None GRM1, GRM5 2.43299
[BP] GO:0046110 None AOX1, XDH 2.43299
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.43299
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, SRC 2.40764
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, APP, AR, CDC25B, FABP4, FLT3, GPER1, GRM1, GRM5, IGF1R, KDR, MMP9, PTPN1, SRC, XDH 2.40764
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, APP, AR, AURKB, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPER1, GRM1, GRM5, IGF1R, KDR, MET, MMP9, PPARA, PTPN1, RORC, SRC, XDH 2.39998
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APP, FABP3, FLT3, GPER1, GRM5, IGF1R, MMP2, PPARA, SRC, TYR 2.38961
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PTPN1, SRC 2.38861
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, SRC 2.38394
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APP, CYP19A1, CYP1B1, GPER1, IGF1R, KDR, MET, MMP9, SRC 2.33877
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.32398
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, APP, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GPER1, GRM3, GRM8, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, RORC, SRC, XDH 2.29904
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD17B1, HSD17B2 2.28434
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, APP, CA2, CA7, GPER1 2.2839
[BP] GO:0010675 None ESRRB, GPER1, PPARA, RORC, SRC 2.2839
[BP] GO:0044057 None ADORA1, ADORA3, CHRM1, CHRM2, CHRM3, GPER1, GRM1, HCAR2, SLC1A1 2.2839
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.28018
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, APP, AR, AXL, CSNK2A1, CYP1B1, ESRRA, FABP4, FLT3, GPER1, GRM1, KDR, MET, MMP2, MMP9, PTPN1, SRC, XDH 2.26757
[BP] GO:0006631 fatty acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, PPARA 2.25689
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.22661
[BP] GO:0043393 regulation of protein binding APP, AURKB, MET, MMP9, PPARA, SRC 2.22084
[BP] GO:0006145 None AOX1, XDH 2.20166
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.20166
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.20166
[BP] GO:1901653 cellular response to peptide AKR1B1, APP, GPER1, GRM5, IGF1R, SRC 2.20166
[BP] GO:2000021 regulation of ion homeostasis ADORA1, CA2, CA7, GPER1, KDR, SRC 2.20166
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.19132
[BP] GO:1901698 response to nitrogen compound AKR1B1, APP, FABP3, FLT3, GPER1, GRM5, IGF1R, MMP2, PPARA, SRC, TYR 2.14911
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APP, CYP19A1, CYP1B1, GPER1, IGF1R, KDR, MET, MMP9, SRC 2.14227
[BP] GO:0006811 None CA1, CA12, CA14, CA2, CA4, CA7, CA9, CHRM5, FABP3, GRIA2, GRIA4, GRIK5, PPARA, SLC1A1 2.14227
[BP] GO:0045913 None ESRRB, GPER1, PPARA, SRC 2.14227
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APP, AR, ESR1, FLT3, GPER1, GRM5, IGF1R, MMP2, SRC 2.1329
[BP] GO:0009893 positive regulation of metabolic process ADORA1, APP, AR, AURKB, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, GPER1, GRM1, GRM5, IGF1R, KDR, MET, MMP9, PPARA, PTPN1, RORC, SRC, XDH 2.12384
[BP] GO:0060079 None ADORA1, GRIA2, GRIA4, GRIK5 2.12303
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, APP, AR, AURKB, CDC25B, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, GPER1, GRM1, GRM5, IGF1R, KDR, MET, MMP9, PPARA, PTPN1, RORC, SRC, XDH 2.11969
[BP] GO:0048545 response to steroid hormone ALPL, AR, CA2, FLT3, GPER1, SRC 2.10306
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, APP, AR, AURKB, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPER1, GRM1, GRM5, IGF1R, KDR, MET, MMP9, PPARA, PTPN1, RORC, SRC, XDH 2.10306
[BP] GO:1903725 regulation of phospholipid metabolic process CHRM5, FABP3, FLT3, SRC 2.06419
[BP] GO:1904646 cellular response to amyloid-beta APP, GRM5, IGF1R 2.06419
[BP] GO:0071383 None AR, FLT3, GPER1, SRC 2.02428
[BP] GO:0061097 None ADORA1, APP, GRM5, PTPN1 2.02428
[BP] GO:0046541 None CHRM1, CHRM3 2.02029
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, APP, AR, AURKB, CDC25B, CSNK2A1, ESR1, FABP4, FLT3, GPER1, GRM1, GRM3, GRM5, IGF1R, MMP9, PTPN1, SRC, XDH 2.00563
[CC] GO:0097060 None CHRM1, CHRM2, CHRM3, CHRM5, GPER1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 6.80268
[CC] GO:0098590 plasma membrane region ADORA1, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, GPER1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, MET, SLC1A1, SRC 6.67341
[CC] GO:0044456 None ACHE, ADORA1, APP, CHRM1, CHRM2, CHRM3, CHRM5, GPER1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, SRC 6.30292
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ALPL, APP, AR, AXL, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, ESR1, FLT3, GPER1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, MMP2, PIM1, PTPN1, SLC1A1, SRC 5.46374
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, APP, AXL, CA4, CHRM1, CHRM2, CHRM3, CHRM5, FLT3, GPER1, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, SLC1A1 4.9433
[CC] GO:0042734 None GPER1, GRIK5, GRM1, GRM3, GRM5, GRM8 4.73186
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, APP, AXL, CHRM1, CHRM2, CHRM3, CHRM5, FLT3, GPER1, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, SLC1A1 4.5867
[CC] GO:0043005 None ADORA1, APP, CA2, CHRM1, CHRM2, CHRM3, GPER1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, SRC 4.19018
[CC] GO:0014069 None ADORA1, CHRM1, GPER1, GRIK5, GRM1, GRM3, GRM5, SRC 4.14936
[CC] GO:0099572 None ADORA1, CHRM1, GPER1, GRIK5, GRM1, GRM3, GRM5, SRC 4.14936
[CC] GO:0045211 None CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIA4, GRIK5, GRM3 3.99031
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, APP, AXL, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, FLT3, GPER1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, SLC1A1, SRC 3.95806
[CC] GO:0098793 None ADORA1, APP, CHRM1, CHRM2, CHRM3, GPER1, GRIK5 3.60863
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ALOX5, ALPL, APP, AR, AXL, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FLT3, FUT7, GPER1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD17B2, IGF1R, KDR, MET, MMP2, PIM1, PTPN1, SLC1A1, SRC, TYR 3.1136
[CC] GO:0044463 None ADORA1, AKR1B1, APP, CA4, CA9, CHRM1, CHRM2, CHRM3, GPER1, GRIA2, GRIA4, GRIK5, GRM3, SRC 2.96699
[CC] GO:0120038 None ADORA1, AKR1B1, APP, CA4, CA9, CHRM1, CHRM2, CHRM3, GPER1, GRIA2, GRIA4, GRIK5, GRM3, SRC 2.96699
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, ALPL, APP, AXL, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FLT3, FUT7, GPER1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD17B2, IGF1R, KDR, MET, PTPN1, SLC1A1, SRC, TYR 2.64006
[CC] GO:0120025 None ADORA1, AKR1B1, APP, CA2, CHRM1, CHRM2, CHRM3, GPER1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, SRC 2.61489
[CC] GO:0045202 None ACHE, APP, CHRM1, CHRM2, CHRM3, CHRM5, GRIA2 2.52263
[CC] GO:0043679 None CHRM1, CHRM2, CHRM3, GPER1 2.42785
[CC] GO:0042995 cell projection ADORA1, AKR1B1, APP, CA2, CHRM1, CHRM2, CHRM3, GPER1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, SRC 2.39392
[CC] GO:0097458 None ADORA1, APP, CA2, CHRM1, CHRM2, CHRM3, GPER1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, SRC 2.35083
[CC] GO:0043197 None ADORA1, APP, GRIA2, GRIA4, GRM3 2.32159
[CC] GO:0044309 None ADORA1, APP, GRIA2, GRIA4, GRM3 2.29301
[CC] GO:0044306 None CHRM1, CHRM2, CHRM3, GPER1 2.10327
[MF] GO:0046914 transition metal ion binding ALOX5, AOX1, APP, AR, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, TYR, XDH 12.6464
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AR, AXL, CHRM1, CHRM2, CHRM3, CHRM5, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPER1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, PPARA, RORC 10.2292
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 9.84488
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AR, AXL, CHRM1, CHRM2, CHRM3, CHRM5, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPER1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, PPARA, RORC 9.24551
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AR, AXL, CHRM1, CHRM2, CHRM3, CHRM5, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPER1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, PPARA, RORC 9.01161
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AR, AXL, CHRM1, CHRM2, CHRM3, CHRM5, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPER1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, PPARA, RORC 8.47011
[MF] GO:0008066 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 8.1956
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding AR, ESR1, ESR2, ESRRA, ESRRB, GPER1, PPARA, RORC 8.16821
[MF] GO:0004879 nuclear receptor activity AR, ESR1, ESR2, ESRRA, ESRRB, GPER1, PPARA, RORC 8.16821
[MF] GO:0005496 steroid binding AR, ESR1, ESR2, ESRRA, ESRRB, GPER1, HSD17B1, RORC, SHBG 7.77199
[MF] GO:0003707 steroid hormone receptor activity AR, ESR1, ESR2, ESRRA, ESRRB, GPER1, PPARA, RORC 7.55467
[MF] GO:0030594 None CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIA4, GRIK5, GRM1, GRM5 6.95353
[MF] GO:0016907 None CHRM1, CHRM2, CHRM3, CHRM5 6.36105
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.36105
[MF] GO:0008270 zinc ion binding AR, CA1, CA12, CA2, CA4, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP2, MMP9, PPARA, PTPN1, RORC 6.26804
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, FLT3, GPER1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET 5.95527
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, FLT3, GPER1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET 5.95527
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 5.57945
[MF] GO:0043167 ion binding ACHE, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, HSD17B1, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SLC1A1, SRC, TYR, XDH 5.46796
[MF] GO:0042562 hormone binding ACHE, AR, CHRM3, GPER1, HSD17B1, IGF1R, SHBG 5.25178
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CBR1, CDC25B, CHRM1, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FLT3, FUT7, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, PTPN1, SRC, TYR, XDH 4.67995
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, AOX1, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CHRM3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SLC1A1, TYR, XDH 4.31983
[MF] GO:0008289 lipid binding AR, AXL, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GPER1, HSD17B1, PPARA, RORC, SHBG 4.16251
[MF] GO:0015464 None CHRM1, CHRM2, CHRM3, CHRM5 4.12119
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, CBR1, HSD17B1, HSD17B2, XDH 4.12119
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2, GPER1 4.1016
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, AOX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, HSD17B2, TYR, XDH 3.861
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.72097
[MF] GO:0005506 iron ion binding ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, XDH 3.70402
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.53308
[MF] GO:0046872 metal ion binding ALOX5, ALPL, AOX1, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SLC1A1, TYR, XDH 3.53308
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.45398
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 3.35496
[MF] GO:0004629 None ADORA1, CHRM1, CHRM3, CHRM5 3.306
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 3.01731
[MF] GO:0099528 None CHRM1, CHRM2, CHRM3, CHRM5 2.96699
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FLT3, IGF1R, KDR, MET, PIM1, PPARA, SRC 2.92859
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.81585
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.73689
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 2.70293
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, TYR 2.67872
[MF] GO:0004930 None ADORA1, ADORA3, CHRM1, CHRM2, CHRM3, CHRM5, GPER1, GRM1, GRM3, GRM5, GRM8, HCAR2 2.50515
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, XDH 2.45439
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, SRC 2.4484
[MF] GO:0099583 None GRM1, GRM5 2.43299
[MF] GO:0004970 None GRIA2, GRIA4, GRIK5 2.43299
[MF] GO:0005234 None GRIA2, GRIA4, GRIK5 2.43299
[MF] GO:0008227 None CHRM1, CHRM2, CHRM3, CHRM5 2.38394
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, CBR1, HSD17B1, HSD17B2 2.30617
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.20166
[MF] GO:0004971 None GRIA2, GRIA4 2.20166
[MF] GO:0005497 None AR, SHBG 2.20166
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, SRC 2.19558
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, CSNK2A1, ESRRB, FLT3, IGF1R, KDR, MMP9, PIM1, PPARA, PTPN1, SRC 2.10327
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, SRC 2.06696
[MF] GO:0004435 None CHRM1, CHRM3, CHRM5 2.06419


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, GRIA2, CHRM3, CHRM1, GRIK5, CHRM5, GRM1, GRM3, GRM5, ADORA3, GRM8, ADORA1, GRIA4 9.6155
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 11.2092
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 8.0115
Glutamatergic synapse_Homo sapiens_hsa04724 GRM3, GRIA2, GRM5, GRIK5, GRM8, SLC1A1, GRM1, GRIA4 7.0085
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, GPER1, MMP9, ESR1, GRM1, ESR2 6.1769
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 6.1769
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, ESR1, IGF1R 4.2406
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, HCAR2, GRIA2, CHRM1, ADORA1, PPARA, GRIA4 4.2406
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MET, IGF1R 4.2406
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, CHRM3, CHRM1, CHRM5 3.5547
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, CHRM3, GRM5, CHRM1, CHRM5, GRM1 3.5792
Metabolic pathways_Homo sapiens_hsa01100 CBR1, AKR1B1, TYR, CYP19A1, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH 3.5547
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1 3.9735
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 3.9714
Pathways in cancer_Homo sapiens_hsa05200 AR, FLT3, MMP1, MMP2, MMP9, MET, IGF1R 2.7231
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CBR1, CYP1A2, CYP1A1, CYP1B1 3.1361
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.2039
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 GRIA2, GRM5, GRM1, GRIA4 2.6878
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, CHRM3, CHRM1, SRC, CHRM5 2.4122
Chemical carcinogenesis_Homo sapiens_hsa05204 CBR1, CYP1A2, CYP1A1, CYP1B1 2.9905
Phospholipase D signaling pathway_Homo sapiens_hsa04072 GRM3, GRM5, GRM8, GRM1 2.1826
Long-term depression_Homo sapiens_hsa04730 GRIA2, GRM1, IGF1R 2.246
MicroRNAs in cancer_Homo sapiens_hsa05206 PIM1, CYP1B1, MMP9, MET, CDC25B 1.9158
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 2.0891
Long-term potentiation_Homo sapiens_hsa04720 GRIA2, GRM5, GRM1 2.1812
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1 2.1826
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, CHRM1, KDR, MET, IGF1R 1.7481
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.9158
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, MET, IGF1R 1.7655
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KDR, MET, IGF1R 1.7481
Gap junction_Homo sapiens_hsa04540 GRM5, SRC, GRM1 1.902
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.4891
Ras signaling pathway_Homo sapiens_hsa04014 KDR, MET, IGF1R 1.0728
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1 1.3462
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.3064
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.342
Amphetamine addiction_Homo sapiens_hsa05031 GRIA2, GRIA4 1.2673
Prostate cancer_Homo sapiens_hsa05215 AR, IGF1R 1.0976
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 1.0878
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, PIM1 1.0427
Taste transduction_Homo sapiens_hsa04742 CHRM3, GRM1 1.1453
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET 1.2673
Gastric acid secretion_Homo sapiens_hsa04971 CHRM3, CA2 1.2213
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 0.9642
Melanoma_Homo sapiens_hsa05218 MET, IGF1R 1.2464
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.3238
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 1.0592
Circadian entrainment_Homo sapiens_hsa04713 GRIA2, GRIA4 1.0689
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.2642
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PPARA 0.997
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5 1.3028
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.1871
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2, AOX1 1.2611
Serotonergic synapse_Homo sapiens_hsa04726 APP, ALOX5 0.983
Pancreatic secretion_Homo sapiens_hsa04972 CHRM3, CA2 1.0681
Cocaine addiction_Homo sapiens_hsa05030 GRM3, GRIA2 1.4464
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, ESR1 0.9626
Oocyte meiosis_Homo sapiens_hsa04114 AR, IGF1R 0.9435
Hepatitis B_Homo sapiens_hsa05161 SRC, MMP9 0.848
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.9626
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, ADORA1 0.9562
Dopaminergic synapse_Homo sapiens_hsa04728 GRIA2, GRIA4 0.9136
FoxO signaling pathway_Homo sapiens_hsa04068 GRM1, IGF1R 0.8965
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 ESRRB, IGF1R 0.8592
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.8693
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1, AOX1 0.8167
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1 0.7902
Nicotine addiction_Homo sapiens_hsa05033 GRIA2, GRIA4 1.5943
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.2513
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.7645
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1 0.3137
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.3125
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3405
Huntington's disease_Homo sapiens_hsa05016 GRM5 0.3246
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3312
Tuberculosis_Homo sapiens_hsa05152 SRC 0.3403
Alzheimer's disease_Homo sapiens_hsa05010 APP 0.3522
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.3312
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.3808
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC 0.3691
Measles_Homo sapiens_hsa05162 CSNK2A1 0.4059
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.3983
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1 0.4021
Platelet activation_Homo sapiens_hsa04611 SRC 0.4275
Hepatitis C_Homo sapiens_hsa05160 PPARA 0.4102
AMPK signaling pathway_Homo sapiens_hsa04152 IGF1R 0.4275
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.4553
Cell cycle_Homo sapiens_hsa04110 CDC25B 0.4275
Axon guidance_Homo sapiens_hsa04360 MET 0.4226
ErbB signaling pathway_Homo sapiens_hsa04012 SRC 0.4934
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5 0.4338
HIF-1 signaling pathway_Homo sapiens_hsa04066 IGF1R 0.4755
Melanogenesis_Homo sapiens_hsa04916 TYR 0.4787
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4787
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.482
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, TYR 1.684
Insulin secretion_Homo sapiens_hsa04911 CHRM3 0.4934
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.4934
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.4934
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.4896
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.4934
Salivary secretion_Homo sapiens_hsa04970 CHRM3 0.4934
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4896
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.4934
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4934
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1 0.4896
Peroxisome_Homo sapiens_hsa04146 XDH 0.4934
Protein digestion and absorption_Homo sapiens_hsa04974 SLC1A1 0.4934
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5455
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.565
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.9197
Bile secretion_Homo sapiens_hsa04976 CA2 0.5445
Glioma_Homo sapiens_hsa05214 IGF1R 0.565
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5637
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.565
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.672
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.565
Shigellosis_Homo sapiens_hsa05131 SRC 0.565
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.7481
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 GRIA2 0.6368
Malaria_Homo sapiens_hsa05144 MET 0.6478
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6542
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.6509
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.6578
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8085
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.8199
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.8199
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.848
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.8167
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.838
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.0261
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.1058
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.2673


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)