TCM-ID Component

Description of the Component

Component ID	TCMH1177
Latin Name	Ilex cornuta
English Name	FOLIUM iLICIS cORNUTAE
Chinese Pinyin Name	Ju Gu Ye
中文名	枸骨叶
TCM Properties
TCM Meridians
Therapeutic Class English
Therapeutic Class Chinese
Functions
Toxicity	NA
Geo-authentic habitats (道地产区)	NA
Reference	Chinese Pharmacopoeia (2015)
Barcode ID	ITSAN835-14
Barcode Source	BOLDSYSTEMS

TCM Prescriptions with the Component

Prescription ID	Prescription English Name	Prescription Chinese Name
TCMF3598	Feng Tong Pills	风痛丸
TCMFx1109	Hua Mo Yan Capsule	滑膜炎胶囊
TCMFx1110	Hua Mo Yan Granules	滑膜炎颗粒
TCMFx94	Hua Mo Yan Tablets	滑膜炎片
TCMF5722	Qing Shen Yin Infusion	清身饮冲剂

Targeted Human Proteins by the Ingredient of Component

Target ID	Gene Symbol	Target Name	Target Class	Uniprot ID
TCMT1	EHMT2	Histone-lysine N-methyltransferase, H3 lysine-9 specific 3	Transferase	Q96KQ7
TCMT101	PTPN1	Protein-tyrosine phosphatase 1B	Hydrolase	P18031
TCMT102	ACP1	Low molecular weight phosphotyrosine protein phosphatase	Hydrolase	P24666
TCMT103	PTPRF	Receptor-type tyrosine-protein phosphatase F (LAR)	Hydrolase	P10586
TCMT112	ADORA3	Adenosine A3 receptor	GPCR	P0DMS8
TCMT131	ACHE	Acetylcholinesterase	Hydrolase	P22303
TCMT132	BCHE	Butyrylcholinesterase	Hydrolase	P06276
TCMT150	RORC	Nuclear receptor ROR-gamma	Nuclear receptor	P51449
TCMT156	CYP19A1	Cytochrome P450 19A1	Oxidoreductase	P11511
TCMT17	POLB	DNA polymerase beta	Transferase	P06746
TCMT171	PTPN6	Protein-tyrosine phosphatase 1C	Hydrolase	P29350
TCMT174	HSD11B1	11-beta-hydroxysteroid dehydrogenase 1	Oxidoreductase	P28845
TCMT18	GAA	Lysosomal alpha-glucosidase	Hydrolase	P10253
TCMT186	MAOB	Monoamine oxidase B	Oxidoreductase	P27338
TCMT190	PTPN2	T-cell protein-tyrosine phosphatase	Hydrolase	P17706
TCMT2	MAPT	Microtubule-associated protein tau	Unclassified	P10636
TCMT213	SLC22A1	Solute carrier family 22 member 1	Transporter	O15245
TCMT217	CYP2C8	Cytochrome P450 2C8	Oxidoreductase	P10632
TCMT218	CYP2B6	Cytochrome P450 2B6	Oxidoreductase	P20813
TCMT219	CYP1A2	Cytochrome P450 1A2	Oxidoreductase	P05177
TCMT223	AKR1B1	Aldose reductase	Oxidoreductase	P15121
TCMT273	NR1H4	Bile acid receptor FXR	Nuclear receptor	Q96RI1
TCMT276	SLCO2B1	Solute carrier organic anion transporter family member 2B1	Transporter	O94956
TCMT277	SLCO1B3	Solute carrier organic anion transporter family member 1B3	Transporter	Q9NPD5
TCMT278	SLCO1B1	Solute carrier organic anion transporter family member 1B1	Transporter	Q9Y6L6
TCMT280	AKR1B10	Aldo-keto reductase family 1 member B10	Oxidoreductase	O60218
TCMT296	ADORA1	Adenosine A1 receptor	GPCR	P30542
TCMT307	KCNH2	HERG	Ion channel	Q12809
TCMT31	CYP2C19	Cytochrome P450 2C19	Oxidoreductase	P33261
TCMT33	CYP3A4	Cytochrome P450 3A4	Oxidoreductase	P08684
TCMT34	CYP2D6	Cytochrome P450 2D6	Oxidoreductase	P10635
TCMT41	IDH1	Isocitrate dehydrogenase [NADP] cytoplasmic	Oxidoreductase	O75874
TCMT423	EGFR	Epidermal growth factor receptor erbB1	Kinase	P00533
TCMT571	ADORA2B	Adenosine A2b receptor	GPCR	P29275
TCMT597	SLC28A3	Solute carrier family 28 member 3	Transporter	Q9HAS3
TCMT620	HSPA8	Heat shock cognate 71 kDa protein	Unclassified	P11142
TCMT63	PPARA	Peroxisome proliferator-activated receptor alpha	Nuclear receptor	Q07869
TCMT632	PNP	Purine nucleoside phosphorylase	Transferase	P00491
TCMT640	CTSD	Cathepsin D	Unclassified	P07339
TCMT704	ERBB2	Receptor protein-tyrosine kinase erbB-2	Kinase	P04626
TCMT707	ADORA2A	Adenosine A2a receptor	GPCR	P29274
TCMT709	SLC28A2	Sodium/nucleoside cotransporter 2	Transporter	O43868
TCMT710	SLC28A1	Sodium/nucleoside cotransporter 1	Transporter	O00337
TCMT729	PIK3CA	PI3-kinase p110-alpha subunit	Transferase	P42336
TCMT730	PIK3CB	PI3-kinase p110-beta subunit	Transferase	P42338
TCMT740	PIK3CG	PI3-kinase p110-gamma subunit	Transferase	P48736
TCMT8	KDM4E	Lysine-specific demethylase 4D-like	Oxidoreductase	B2RXH2
TCMT80	MAPK1	MAP kinase ERK2	Kinase	P28482
TCMT87	CYP2C9	Cytochrome P450 2C9	Oxidoreductase	P11712

Targeted Pathogenic Microbes by the Ingredient of Component

Target ID	Target Name
TCMT1107	Protease
TCMT1121	Sialidase
TCMT1218	Staphylococcus aureus
TCMT1229	Enterococcus faecalis
TCMT1246	Escherichia coli
TCMT1255	Human immunodeficiency virus 1
TCMT1412	Salmonella typhimurium
TCMT1458	Filobasidiella neoformans
TCMT1463	Mycobacterium tuberculosis

Ingredient Structrues

Ingredient ID: TCMC850
Formula: C8H10N4O2

Common Name	Caffeine
IUPAC Name	1,3,7-trimethylpurine-2,6-dione
Canonical SMILES	Cn1cnc2c1c(=O)n(C)c(=O)n2C
Standard InCHI	InChI=1S/C8H10N4O2/c1-10-4-9-6-5(10)7(13)12(3)8(14)11(6)2/h4H,1-3H3
Standard InCHIKey	RYYVLZVUVIJVGH-UHFFFAOYSA-N
External Identifiers	ChEMBL [CHEMBL113]; PubChem [2519];
Reference of Component-Ingredient Pair	N/A

Occurrence of the ingredient across TCM components

Component ID	Latin Name	Pinyin Name	Chinese Name
TCMH914	Sesamum indicum	Hu Ma Ren	胡麻仁
TCMH1177	Ilex cornuta	Ju Gu Ye	枸骨叶
TCMH561	Senegalia catechu	Fang Er Cha	方儿茶
TCMH2710	Homo sapiens	Zi He Che	紫河车
TCMH2215	Ficus simplicissima	Wu Zhi Mao Tao	五指毛桃
TCMH226	Camellia sinensis	Cha Ye	茶叶
TCMH2200	Firmiana simplex	Wu Tong Ye Jin Gao	梧桐叶浸膏
TCMH1680	Sinomenium acutum	Qing Feng Teng	青风藤
TCMH565	Stephania tetrandra	Fang Ji	防己
TCMH970	Vitex negundo	Huang Jing Zi	黄荆子
TCMH920	Quercus dentata	Hu Ye Gan Jin Gao	槲叶干浸膏
TCMH1734	Homo sapiens	Ren Zhong Bai	人中白
TCMH848	Sesamum indicum	Hei Zhi Ma	黑芝麻
TCMH913	Sesamum indicum	Hu Ma	胡麻
TCMH51	Camellia sinensis	Bai Cha	白茶

Ingredient ID: TCMC732
Formula: C30H48O5

Common Name	Asiatic Acid
IUPAC Name	(1S,2R,4aS,6aR,6aS,6bR,8aR,9R,10R,11R,12aR,14bS)-10,11-dihydroxy-9-(hydroxymethyl)-1,2,6a,6b,9,12a-hexamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydro-1H-picene-4a-carboxylic acid
Canonical SMILES	OC[C@]1(C)[C@@H](O)[C@H](O)C[C@]2([C@H]1CC[C@@]1([C@@H]2CC=C2[C@@]1(C)CC[C@@]1([C@H]2[C@@H](C)[C@@H](CC1)C)C(=O)O)C)C
Standard InCHI	InChI=1S/C30H48O5/c1-17-9-12-30(25(34)35)14-13-28(5)19(23(30)18(17)2)7-8-22-26(3)15-20(32)24(33)27(4,16-31)21(26)10-11-29(22,28)6/h7,17-18,20-24,31-33H,8-16H2,1-6H3,(H,34,35)/t17-,18+,20-,21-,22-,23+,24+,26+,27+,28-,29-,30+/m1/s1
Standard InCHIKey	JXSVIVRDWWRQRT-UYDOISQJSA-N
External Identifiers	ChEMBL [CHEMBL404313]; PubChem [119034];
Reference of Component-Ingredient Pair	27395046

Occurrence of the ingredient across TCM components

Component ID	Latin Name	Pinyin Name	Chinese Name
TCMH183	Dryobalanops aromatica	Bing Pian	冰片
TCMH1177	Ilex cornuta	Ju Gu Ye	枸骨叶
TCMH2286	Berberis julianae	Xiao Bo Gen	小檗根
TCMH2261	Fritillaria thunbergii	Xiang Bei	象贝
TCMH1033	Centella asiatica	Ji Xue Cao	积雪草

Ingredient ID: TCMC724
Formula: C30H48O5

Common Name	Arjunolic Acid
IUPAC Name	(4aS,6aR,6aS,6bR,8aR,9R,10R,11R,12aR,14bS)-10,11-dihydroxy-9-(hydroxymethyl)-2,2,6a,6b,9,12a-hexamethyl-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid
Canonical SMILES	OC[C@]1(C)[C@@H](O)[C@H](O)C[C@]2([C@H]1CC[C@@]1([C@@H]2CC=C2[C@@]1(C)CC[C@@]1([C@H]2CC(CC1)(C)C)C(=O)O)C)C
Standard InCHI	InChI=1S/C30H48O5/c1-25(2)11-13-30(24(34)35)14-12-28(5)18(19(30)15-25)7-8-22-26(3)16-20(32)23(33)27(4,17-31)21(26)9-10-29(22,28)6/h7,19-23,31-33H,8-17H2,1-6H3,(H,34,35)/t19-,20+,21+,22+,23-,26-,27-,28+,29+,30-/m0/s1
Standard InCHIKey	RWNHLTKFBKYDOJ-DDHMHSPCSA-N
External Identifiers	ChEMBL [CHEMBL464466]; PubChem [73641];
Reference of Component-Ingredient Pair	N/A

Occurrence of the ingredient across TCM components

Component ID	Latin Name	Pinyin Name	Chinese Name
TCMH2729	Campsis grandiflora	Zi Wei Gen Pi	紫葳根皮
TCMH1177	Ilex cornuta	Ju Gu Ye	枸骨叶
TCMH1817	Mussaenda pubescens	Shan Gan Cao	山甘草
TCMH559	Psidium guajava	Fan Shi Liu Ye	番石榴叶
TCMH1588	Achyranthes bidentata	Niu Xi	牛膝
TCMH1643	Syzygium jambos	Pu Tao(1)	蒲桃
TCMH1584	Achyranthes bidentata	Niu Teng	牛藤

Ingredient ID: TCMC632
Formula: C10H13N5O4

Common Name	Adenosine
IUPAC Name	(2R,3R,4S,5R)-2-(6-aminopurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol
Canonical SMILES	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N
Standard InCHI	InChI=1S/C10H13N5O4/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(18)6(17)4(1-16)19-10/h2-4,6-7,10,16-18H,1H2,(H2,11,12,13)/t4-,6-,7-,10-/m1/s1
Standard InCHIKey	OIRDTQYFTABQOQ-KQYNXXCUSA-N
External Identifiers	ChEMBL [CHEMBL477]; PubChem [60961];
Reference of Component-Ingredient Pair	29968805

Occurrence of the ingredient across TCM components

Component ID	Latin Name	Pinyin Name	Chinese Name
TCMH86	Ampelopsis japonica	Bai Lian	白蔹
TCMH914	Sesamum indicum	Hu Ma Ren	胡麻仁
TCMH211	Atractylodes lancea	Cang Zhu	苍术
TCMH1656	Angelica decursiva	Qian Hu	前胡
TCMH382	Allium sativum	Da Suan	大蒜
TCMH1626	Fritillaria ussuriensis	Ping Bei Mu	平贝母
TCMH1177	Ilex cornuta	Ju Gu Ye	枸骨叶
TCMH2469	Fritillaria pallidiflora	Yi Bei Mu	伊贝母
TCMH865	Carthamus tinctorius	Hong Hua	红花
TCMH2703	Fritillaria unibracteata	Zi Bei Mu	紫贝母
TCMH274	Fritillaria cirrhosa	Chuan Bei Mu Liu Jin Gao	川贝母流浸膏
TCMH2137	Pogostemon cablin	Tu Huo Xiang	土藿香
TCMH1791	Loranthus parasiticus	Sang Ji Sheng	桑寄生
TCMH985	Astragalus membranaceus	Huang Qi Ti Qu Ye	黄芪提取液
TCMH2710	Homo sapiens	Zi He Che	紫河车
TCMH1894	Pinellia ternata	Sheng Ban Xia	生半夏
TCMH1299	Ganoderma lucidum	Ling Zhi(1)	灵芝
TCMH428	Codonopsis pilosula	Dang Shen Qing Gao	党参清膏
TCMH1322	Solanum nigrum	Long Kui	龙葵
TCMH422	Angelica sinensis	Dang Gui Gan Jin Gao	当归干浸膏
TCMH1839	Panax ginseng	Shan Shen	山参
TCMH2309	Allium macrostemon	Xie Bai	薤白
TCMH1519	Oroxylum indicum	Mu Hu Die	木蝴蝶
TCMH2090	Gastrodia elata	Tian Ma	天麻
TCMH388	Ziziphus jujuba	Da Zao	大枣
TCMH2293	Phaseolus vulgaris	Xiao Hei Dou	小黑豆
TCMH1197	Selaginella tamariscina	Juan Bai	卷柏
TCMH2261	Fritillaria thunbergii	Xiang Bei	象贝
TCMH1966	Rehmannia glutinosa	Shu Di Huang	熟地黄
TCMH2414	Allium cepa	Yang Cong Tou	洋葱头
TCMH2086	Trichosanthes kirilowii	Tian Hua Fen	天花粉
TCMH970	Vitex negundo	Huang Jing Zi	黄荆子
TCMH2376	Corydalis yanhusuo	Yan Hu Suo	延胡索
TCMH2297	Cirsium setosum	Xiao Ji	小蓟
TCMH2590	Pinellia pedatisecta	Zhang Ye Ban Xia	掌叶半夏
TCMH2356	Daemonorops draco	Xue Xie	血蝎
TCMH1483	Tussilago farfara	Mi Kuan Dong Hua	蜜款冬花
TCMH494	Cordyceps sinensis	Dong Chong Xia Cao	冬虫夏草
TCMH1176	Allium tuberosum	Jiu Zi	韭子
TCMH148	Glehnia littoralis	Bei Sha Shen Liu Jin Gao	北沙参流浸膏
TCMH562	Saposhnikovia divaricata	Fang Feng	防风
TCMH1305	Laggera alata	Liu Ling Ju	六棱菊
TCMH1428	Ophiopogon japonicus	Mai Men Dong	麦门冬
TCMH1714	Lonicera japonica	Ren Dong Teng	忍冬藤
TCMH2553	Scrophularia ningpoensis	Yuan Shen	元参
TCMH1777	Panax notoginseng	San Qi Ye Jing	三七叶茎
TCMH1512	Isatis indigotica	Mu Da Qing Ye	木大青叶
TCMH1155	Allium tuberosum	Jiu Cai	韭菜
TCMH273	Fritillaria cirrhosa	Chuan Bei Mu	川贝母
TCMH1127	Lonicera japonica	Jin Yin Hua	金银花
TCMH1128	Lonicera japonica	Jin Yin Hua Ti Qu Ye	金银花提取液
TCMH421	Angelica sinensis	Dang Gui	当归
TCMH426	Codonopsis pilosula	Dang Shen	党参
TCMH1734	Homo sapiens	Ren Zhong Bai	人中白
TCMH130	Pinellia ternata	Ban Xia	半夏
TCMH131	Pinellia ternata	Ban Xia Qu	半夏曲
TCMH1677	Pinellia ternata	Qing Ban Xia	清半夏
TCMH705	Trichosanthes kirilowii	Gua Lou	瓜蒌
TCMH706	Trichosanthes kirilowii	Gua Lou Pi	瓜蒌皮
TCMH707	Trichosanthes kirilowii	Gua Lou Ren	瓜蒌仁
TCMH708	Trichosanthes kirilowii	Gua Lou Ren Shuang	瓜蒌仁霜
TCMH709	Trichosanthes kirilowii	Gua Lou Shi	栝蒌实
TCMH711	Trichosanthes kirilowii	Gua Lou Gen	栝楼根
TCMH712	Trichosanthes kirilowii	Gua Lou Ren(1)	栝楼仁
TCMH1770	Panax notoginseng	San Qi Gan Jin Gao	三七干浸膏
TCMH1771	Panax notoginseng	San Qi Gao Fen	三七膏粉
TCMH1772	Panax notoginseng	San Qi Hua	三七花
TCMH1774	Panax notoginseng	San Qi Jing Ye	三七茎叶
TCMH1776	Panax notoginseng	San Qi Ye	三七叶
TCMH2413	Allium cepa	Yang Cong	洋葱
TCMH848	Sesamum indicum	Hei Zhi Ma	黑芝麻
TCMH913	Sesamum indicum	Hu Ma	胡麻
TCMH981	Astragalus membranaceus	Huang Qi	黄芪
TCMH983	Astragalus membranaceus	Huang Qi Gan Jin Gao	黄芪干浸膏
TCMH984	Astragalus membranaceus	Huang Qi Jin Gao	黄芪浸膏
TCMH1296	Ganoderma lucidum	Ling Zhi Jin Gao	灵芝浸膏
TCMH1721	Panax ginseng	Ren Shen	人参
TCMH1728	Panax ginseng	Ren Shen Ye	人参叶
TCMH519	Pogostemon cablin	Du Huo Xiang	杜藿香
TCMH728	Pogostemon cablin	Guang Huo Xiang	广藿香
TCMH1008	Pogostemon cablin	Huo Xiang	藿香
TCMH1009	Pogostemon cablin	Huo Xiang Ye	藿香叶
TCMH126	Isatis indigotica	Ban Lan	板蓝
TCMH127	Isatis indigotica	Ban Lan Gen	板蓝根
TCMH381	Isatis indigotica	Da Qing Ye	大青叶
TCMH1510	Isatis indigotica	Mu Ban Lan Gen	木板蓝根
TCMH1223	Tussilago farfara	Kuan Dong Hua	款冬花
TCMH8	Rehmannia glutinosa	Ai Di Huang	矮地黄
TCMH451	Rehmannia glutinosa	Di Huang	地黄
TCMH453	Rehmannia glutinosa	Di Huang Tan	地黄炭
TCMH643	Rehmannia glutinosa	Gan Di Huang	干地黄
TCMH147	Glehnia littoralis	Bei Sha Shen	北沙参
TCMH1423	Ophiopogon japonicus	Mai Dong	麦冬
TCMH1424	Ophiopogon japonicus	Mai Dong Men	麦冬门
TCMH1425	Ophiopogon japonicus	Mai Dong Rou	麦冬肉
TCMH2343	Scrophularia ningpoensis	Xuan Shen	玄参

Ingredient ID: TCMC350
Formula: C30H48O4

Common Name	23-Hydroxyursolic Acid
IUPAC Name	(1S,2R,4aS,6aR,6aS,6bR,8aR,9R,10S,12aR,14bS)-10-hydroxy-9-(hydroxymethyl)-1,2,6a,6b,9,12a-hexamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydro-1H-picene-4a-carboxylic acid
Canonical SMILES	OC[C@]1(C)[C@@H](O)CC[C@]2([C@H]1CC[C@@]1([C@@H]2CC=C2[C@@]1(C)CC[C@@]1([C@H]2[C@@H](C)[C@@H](CC1)C)C(=O)O)C)C
Standard InCHI	InChI=1S/C30H48O4/c1-18-9-14-30(25(33)34)16-15-28(5)20(24(30)19(18)2)7-8-22-26(3)12-11-23(32)27(4,17-31)21(26)10-13-29(22,28)6/h7,18-19,21-24,31-32H,8-17H2,1-6H3,(H,33,34)/t18-,19+,21-,22-,23+,24+,26+,27+,28-,29-,30+/m1/s1
Standard InCHIKey	NZCULBURCGAPSF-PQWKYGPVSA-N
External Identifiers	ChEMBL [CHEMBL523622]; PubChem [14136881];
Reference of Component-Ingredient Pair	N/A

Occurrence of the ingredient across TCM components

Component ID	Latin Name	Pinyin Name	Chinese Name
TCMH2729	Campsis grandiflora	Zi Wei Gen Pi	紫葳根皮
TCMH1177	Ilex cornuta	Ju Gu Ye	枸骨叶
TCMH226	Camellia sinensis	Cha Ye	茶叶
TCMH261	Ericerus pela	Chong Bai La	虫白蜡
TCMH2261	Fritillaria thunbergii	Xiang Bei	象贝
TCMH51	Camellia sinensis	Bai Cha	白茶

Ingredient ID: TCMC2807
Formula: C24H24O6

Common Name	10-O-Methylmacluraxanthone
IUPAC Name	5,9-dihydroxy-10-methoxy-2,2-dimethyl-12-(2-methylbut-3-en-2-yl)pyrano[3,2-b]xanthen-6-one
Canonical SMILES	C=CC(c1c2OC(C)(C)C=Cc2c(c2c1oc1c(OC)c(O)ccc1c2=O)O)(C)C
Standard InCHI	InChI=1S/C24H24O6/c1-7-23(2,3)16-19-13(10-11-24(4,5)30-19)18(27)15-17(26)12-8-9-14(25)21(28-6)20(12)29-22(15)16/h7-11,25,27H,1H2,2-6H3
Standard InCHIKey	XPXBUMXEOVNYQI-UHFFFAOYSA-N
External Identifiers	ChEMBL [CHEMBL2147811]; PubChem [71458306];
Reference of Component-Ingredient Pair	N/A

Occurrence of the ingredient across TCM components

Component ID	Latin Name	Pinyin Name	Chinese Name
TCMH1177	Ilex cornuta	Ju Gu Ye	枸骨叶

Ingredient ID: TCMC2522
Formula: C24H24O6

Common Name	5-O-Methylxanthone V1
IUPAC Name	5,9-dihydroxy-10-methoxy-2,2-dimethyl-12-(3-methylbut-2-enyl)pyrano[3,2-b]xanthen-6-one
Canonical SMILES	COc1c(O)ccc2c1oc1c(CC=C(C)C)c3OC(C)(C)C=Cc3c(c1c2=O)O
Standard InCHI	InChI=1S/C24H24O6/c1-12(2)6-7-15-20-14(10-11-24(3,4)30-20)19(27)17-18(26)13-8-9-16(25)23(28-5)22(13)29-21(15)17/h6,8-11,25,27H,7H2,1-5H3
Standard InCHIKey	PZHQEWQFKUTZTQ-UHFFFAOYSA-N
External Identifiers	ChEMBL [CHEMBL2147810]; PubChem [12178329];
Reference of Component-Ingredient Pair	N/A

Occurrence of the ingredient across TCM components

Component ID	Latin Name	Pinyin Name	Chinese Name
TCMH1177	Ilex cornuta	Ju Gu Ye	枸骨叶

Ingredient ID: TCMC2216
Formula: C30H48O3

Common Name	Ursolic Acid
IUPAC Name	(1S,2R,4aS,6aR,6aS,6bR,8aR,10S,12aR,14bS)-10-hydroxy-1,2,6a,6b,9,9,12a-heptamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydro-1H-picene-4a-carboxylic acid
Canonical SMILES	C[C@@H]1CC[C@]2([C@@H]([C@H]1C)C1=CC[C@H]3[C@@]([C@@]1(CC2)C)(C)CC[C@@H]1[C@]3(C)CC[C@@H](C1(C)C)O)C(=O)O
Standard InCHI	InChI=1S/C30H48O3/c1-18-10-15-30(25(32)33)17-16-28(6)20(24(30)19(18)2)8-9-22-27(5)13-12-23(31)26(3,4)21(27)11-14-29(22,28)7/h8,18-19,21-24,31H,9-17H2,1-7H3,(H,32,33)/t18-,19+,21+,22-,23+,24+,27+,28-,29-,30+/m1/s1
Standard InCHIKey	WCGUUGGRBIKTOS-GPOJBZKASA-N
External Identifiers	ChEMBL [CHEMBL169]; PubChem [64945];
Reference of Component-Ingredient Pair	27085377

Occurrence of the ingredient across TCM components

Component ID	Latin Name	Pinyin Name	Chinese Name
TCMH2729	Campsis grandiflora	Zi Wei Gen Pi	紫葳根皮
TCMH1862	Cornus officinalis	Shan Zhu Yu	山茱萸
TCMH2006	Geum japonicum	Shui Yang Mei Gen	水杨梅根
TCMH1126	Craibiodendron yunnanese	Jin Ye Zi	金叶子
TCMH2026	Lignum pini nodi	Song Jie	松节
TCMH695	Uncaria rhynchophylla	Gou Teng	钩藤
TCMH1144	Schizonepetae herba	Jing Jie Tan	荆芥炭
TCMH2012	Lycopus lucidus	Shui Ze Lan	水泽兰
TCMH1348	Liquidambar formosana	Lu Lu Tong	路路通
TCMH1177	Ilex cornuta	Ju Gu Ye	枸骨叶
TCMH241	Plantago asiatica	Che Qian Zi	车前子
TCMH2134	Smilax glabra	Tu Fu Ling	土茯苓
TCMH281	Dipsacus asper	Chuan Duan	川断
TCMH2145	Achyranthes aspera	Tu Niu Xi	土牛膝
TCMH274	Fritillaria cirrhosa	Chuan Bei Mu Liu Jin Gao	川贝母流浸膏
TCMH1562	Arctium lappa	Niu Bang Zi	牛蒡子
TCMH2244	Prunella vulgaris	Xia Ku Cao	夏枯草
TCMH316	Ailanthi cortex	Chun Pi	椿皮
TCMH25	Styrax benzoin	An Xi Xiang	安息香
TCMH1141	Schizonepeta tenuifolia	Jing Jie	荆芥
TCMH2706	Lithospermum erythrorhizon	Zi Cao	紫草
TCMH1649	Toxicodendron succedaneum	Qi Shu Gen	漆树根
TCMH1105	Trollius chinensis	Jin Lian Hua	金莲花
TCMH2050	Punica granatum	Suan Shi Liu	酸石榴
TCMH226	Camellia sinensis	Cha Ye	茶叶
TCMH409	Salvia miltiorrhiza	Dan Shen Jin Gao	丹参浸膏
TCMH445	Hypericum japonicum	Di Er Cao	地耳草
TCMH2275	Dracocephalum moldavica	Xiang Qing Lan	香青兰
TCMH2462	Crataegus pinnatifida	Ye Shan Zha	野山楂
TCMH308	Dipsacus asperoides	Chuan Xu Duan	川续断
TCMH108	Perilla frutescens	Bai Su Zi	白苏子
TCMH526	Eucommia ulmoides	Du Zhong Ye	杜仲叶
TCMH1432	Vitex trifolia	Man Jing Zi	蔓荆子
TCMH2286	Berberis julianae	Xiao Bo Gen	小檗根
TCMH1446	Vaccinium oxycoccos	Man Yue Mei	蔓越莓
TCMH1597	Ligustrum lucidum	Nv Zhen Zi	女贞子
TCMH261	Ericerus pela	Chong Bai La	虫白蜡
TCMH2129	Eupolyphaga sinensis	Tu Bie Chong	土鳖虫
TCMH388	Ziziphus jujuba	Da Zao	大枣
TCMH1393	Verbena officinalis	Ma Bian Cao	马鞭草
TCMH685	Syzygium aromaticum	Gong Ding Xiang	公丁香
TCMH74	Patrinia villosa	Bai Jiang	败酱
TCMH1615	Eriobotrya japonica	Pi Ba Ren	枇杷仁
TCMH1518	Chaenomeles sinensis	Mu Gua	木瓜
TCMH2261	Fritillaria thunbergii	Xiang Bei	象贝
TCMH1735	Kummerowia striata	Ren Zi Cao	人字草
TCMH1033	Centella asiatica	Ji Xue Cao	积雪草
TCMH1854	Crataegi folium	Shan Zha Ye	山楂叶
TCMH1958	Diospyros kaki	Shi Ye	柿叶
TCMH1452	Gerbera piloselloides	Mao Da Ding Cao	毛大丁草
TCMH2056	Cynomorium songaricum	Suo Yang	锁阳
TCMH1660	Senecio scandens	Qian Li Guang	千里光
TCMH863	Salvia prionitis	Hong Gen Cao	红根草
TCMH1121	Cardiospermum halicacabum	Jin Si Ku Lian	金丝苦楝
TCMH2225	Cacumen tamaricis	Xi He Liu	西河柳
TCMH2356	Daemonorops draco	Xue Xie	血蝎
TCMH2371	Juniperus formosana	Yan Bai	岩柏
TCMH1135	Rosa laevigata	Jin Ying Zi Ti Qu Ye	金樱子提取液
TCMH76	Thlaspi arvense	Bai Jiang Cao	败酱草
TCMH1466	Rosa rugosa	Mei Gui Hua	玫瑰花
TCMH71	Oldenlandia diffusa	Bai Hua She She Cao	白花蛇舌草
TCMH1272	Forsythia suspensa	Lian Qiao	连翘
TCMH1331	Rhaponticum uniflorum	Lou Lu	漏芦
TCMH906	Viscum coloratum	Hu Ji Sheng	槲寄生
TCMH1741	Myristica fragrans	Rou Dou Kou	肉豆蔻
TCMH1305	Laggera alata	Liu Ling Ju	六棱菊
TCMH2165	Potentilla chinensis	Wei Ling Cai	委陵菜
TCMH1142	Schizonepetae spica	Jing Jie Sui	荆芥穗
TCMH1714	Lonicera japonica	Ren Dong Teng	忍冬藤
TCMH2213	Ipomoea cairica	Wu Zhao Long	五爪龙
TCMH737	Crataegus pinnatifida	Guang Shan Zha	广山楂
TCMH1848	Crataegus pinnatifida	Shan Zha	山楂
TCMH1849	Crataegus pinnatifida	Shan Zha Chou Gao	山楂稠膏
TCMH1852	Crataegus pinnatifida	Shan Zha Qing Gao	山楂清膏
TCMH1853	Crataegus pinnatifida	Shan Zha Tan	山楂炭
TCMH1175	Cornus officinalis	Jiu Yu Rou	酒萸肉
TCMH273	Fritillaria cirrhosa	Chuan Bei Mu	川贝母
TCMH1127	Lonicera japonica	Jin Yin Hua	金银花
TCMH1128	Lonicera japonica	Jin Yin Hua Ti Qu Ye	金银花提取液
TCMH483	Kummerowia striata	Ding Kui Cao	丁葵草
TCMH1039	Kummerowia striata	Ji Yan Cao	鸡眼草
TCMH524	Eucommia ulmoides	Du Zhong	杜仲
TCMH525	Eucommia ulmoides	Du Zhong Tan	杜仲炭
TCMH592	Liquidambar formosana	Feng Xiang Ye	枫香叶
TCMH594	Liquidambar formosana	Feng Xiang Zhi Chou Gao	枫香脂稠膏
TCMH431	Achyranthes aspera	Dao Kou Cao	倒扣草
TCMH1943	Punica granatum	Shi Liu	石榴
TCMH1944	Punica granatum	Shi Liu Pi	石榴皮
TCMH1945	Punica granatum	Shi Liu Zi	石榴子
TCMH1431	Vitex trifolia	Man Jing Ye	蔓荆叶
TCMH1927	Diospyros kaki	Shi Di	柿蒂
TCMH2005	Geum japonicum	Shui Yang Mei	水杨梅
TCMH486	Syzygium aromaticum	Ding Xiang	丁香
TCMH92	Gerbera piloselloides	Bai Mei	白眉
TCMH407	Salvia miltiorrhiza	Dan Shen	丹参
TCMH408	Salvia miltiorrhiza	Dan Shen Gan Jin Gao	丹参干浸膏
TCMH1133	Rosa laevigata	Jin Ying Zi	金樱子
TCMH1134	Rosa laevigata	Jin Ying Zi Rou	金樱子肉
TCMH51	Camellia sinensis	Bai Cha	白茶

Ingredient ID: TCMC1520
Formula: C23H22O6

Common Name	Macluraxanthone
IUPAC Name	5,9,10-trihydroxy-2,2-dimethyl-12-(2-methylbut-3-en-2-yl)pyrano[3,2-b]xanthen-6-one
Canonical SMILES	C=CC(c1c2OC(C)(C)C=Cc2c(c2c1oc1c(O)c(O)ccc1c2=O)O)(C)C
Standard InCHI	InChI=1S/C23H22O6/c1-6-22(2,3)15-19-12(9-10-23(4,5)29-19)17(26)14-16(25)11-7-8-13(24)18(27)20(11)28-21(14)15/h6-10,24,26-27H,1H2,2-5H3
Standard InCHIKey	XRVLGJCHUWXTDX-UHFFFAOYSA-N
External Identifiers	ChEMBL [CHEMBL478960]; PubChem [5281646];
Reference of Component-Ingredient Pair	N/A

Occurrence of the ingredient across TCM components

Component ID	Latin Name	Pinyin Name	Chinese Name
TCMH143	Albizia julibrissin	Bei He Huan	北合欢
TCMH1177	Ilex cornuta	Ju Gu Ye	枸骨叶
TCMH321	Rosa roxburghii	Ci Li Guo	刺梨果
TCMH693	Cudrania cochinchinensis	Gou Ji	狗脊
TCMH816	Albizzia julibrissin	He Huan Pi	合欢皮

Ingredient ID: TCMC1244
Formula: C23H24O6

Common Name	Gerontoxanthone I
IUPAC Name	1,3,5,6-tetrahydroxy-4-(2-methylbut-3-en-2-yl)-2-(3-methylbut-2-enyl)xanthen-9-one
Canonical SMILES	C=CC(c1c(O)c(CC=C(C)C)c(c2c1oc1c(O)c(O)ccc1c2=O)O)(C)C
Standard InCHI	InChI=1S/C23H24O6/c1-6-23(4,5)16-19(27)12(8-7-11(2)3)17(25)15-18(26)13-9-10-14(24)20(28)21(13)29-22(15)16/h6-7,9-10,24-25,27-28H,1,8H2,2-5H3
Standard InCHIKey	SHKQTNVZRNUENO-UHFFFAOYSA-N
External Identifiers	ChEMBL [CHEMBL478791]; PubChem [14412270];
Reference of Component-Ingredient Pair	N/A

Occurrence of the ingredient across TCM components

Component ID	Latin Name	Pinyin Name	Chinese Name
TCMH1177	Ilex cornuta	Ju Gu Ye	枸骨叶
TCMH693	Cudrania cochinchinensis	Gou Ji	狗脊

Properties

Ingredient ID	Formulae	Name	MW	AlogP	MlogP	XlogP	# HBA	# HBD	PSA	# Rotatable Bond	# Ring	# Heacy Atom	Lipinski RO5 Violation
TCMC350	C30H48O4	23-Hydroxyursolic Acid	472.36	0.3931	4.32	8.251	4	3	77.76	11	5	34	1
TCMC632	C10H13N5O4	Adenosine	267.1	-2.2791	1.57	-1.809	9	4	139.54	6	3	19	0
TCMC724	C30H48O5	Arjunolic Acid	488.35	0.8164	4.21	7.537	5	4	97.99	12	5	35	1
TCMC732	C30H48O5	Asiatic Acid	488.35	0.1704	4.21	7.439	5	4	97.99	12	5	35	1
TCMC850	C8H10N4O2	Caffeine	194.08	-0.4311	1.68	-0.625	6	0	58.44	3	2	14	0
TCMC1244	C23H24O6	Gerontoxanthone I	396.16	1.24	3.33	3.35	1	4	107.22	12	3	29	0
TCMC1520	C23H22O6	Macluraxanthone	394.14	0.7307	3.33	3.28	1	3	96.22	9	4	29	0
TCMC2216	C30H48O3	Ursolic Acid	456.36	1.4838	4.43	8.954	3	2	57.53	10	5	33	1
TCMC2522	C24H24O6	5-O-Methylxanthone V1	408.16	1.3949	3.44	3.04	1	2	85.22	10	4	30	0
TCMC2807	C24H24O6	10-O-Methylmacluraxanthone	408.16	1.1392	3.44	3.37	1	2	85.22	10	4	30	0

Download Data

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Data Section	Select to Download
1. General Information of the Component
2. TCM Prescriptions with the Component
3. Putative Targets
4. Activity & References for Filtering Putative Targets
5. Ingredient Data & Chemical Structure Information (Properties, InChI, InChIkey, SMILES, etc.)

Component: Ilex cornuta 枸骨叶

Description of the Component

Component ID

Latin Name

English Name

Chinese Pinyin Name

中文名

TCM Properties

TCM Meridians

Therapeutic Class English

Therapeutic Class Chinese

Functions

Toxicity

Geo-authentic habitats (道地产区)

Reference

Barcode ID

Barcode Source

TCM Prescriptions with the Component

Targeted Human Proteins by the Ingredient of Component

Targeted Pathogenic Microbes by the Ingredient of Component

Ingredient Structrues

Ingredient ID: TCMC850

Occurrence of the ingredient across TCM components

Ingredient ID: TCMC732

Occurrence of the ingredient across TCM components

Ingredient ID: TCMC724

Occurrence of the ingredient across TCM components

Ingredient ID: TCMC632

Occurrence of the ingredient across TCM components

Ingredient ID: TCMC350

Occurrence of the ingredient across TCM components

Ingredient ID: TCMC2807

Occurrence of the ingredient across TCM components

Ingredient ID: TCMC2522

Occurrence of the ingredient across TCM components

Ingredient ID: TCMC2216

Occurrence of the ingredient across TCM components

Ingredient ID: TCMC1520

Occurrence of the ingredient across TCM components

Ingredient ID: TCMC1244

Occurrence of the ingredient across TCM components

Properties

Download Data