TCM-ID Prescription

Prescription Description

Prescription ID	TCMFx3678
Pinyin Name	Guan Jie Jie Tong Gao
Chinese Name	关节解痛膏
English Name	Guan Jie Jie Tong Ointment
Function Description	痹病, 腰痛, 跌打损伤
Indications	Lumbago disorder, Arthritis
Disease ICD-11 Category	SC61 [Lumbago disorder (TM1), 腰痛 (TM1) ]; FA2Z [Inflammatory arthropathies, unspecified, 炎性关节病，未特指的 ];
Human Tissues Associated with Indication	SkeletalMuscle, Blood
Reference	CFDA
Reference Book/link	http://samr.cfda.gov.cn/WS01/CL0001/

Prescription Components

Component ID	Latin Name	Chinese Name	Component Quantity	Barcode
TCMH1228	Capsicum frutescens	辣椒	TCMH1228	ITSAL4555-14
TCMH118	Angelica dahurica	白芷	TCMH118	ITSAK3312-14
TCMH2239	Asarum sieboldii	细辛	TCMH2239	ITSAI1576-14
TCMH1063	Curcuma longa	姜黄	TCMH1063	ITSAP2805-14
TCMH1742	Cinnamomum cassia	肉桂	TCMH1742	GQ255631
TCMH296	Radix aconiti	川乌	TCMH296
TCMH222	Aconitum carmichaelii	草乌	TCMH222	ITSAH2410-14
TCMH700	Drynaria fortunei	骨碎补	TCMH700	GBVM3977-11
TCMH2185	Acanthopanax gracilistylus	五加皮	TCMH2185
TCMH865	Carthamus tinctorius	红花	TCMH865	ITSAI2447-14
TCMH2094	Arisaema consanguineum	天南星	TCMH2094	GBVY604-14
TCMH130	Pinellia ternata	半夏	TCMH130	GBVT1123-13, GBVY1693-14
TCMH1554	Rhododendron molle	闹羊花	TCMH1554	ITSAL4577-14
TCMH562	Saposhnikovia divaricata	防风	TCMH562	ITSAE3225-14
TCMH517	Angelica pubescens	独活	TCMH517	ITSAF170-14
TCMH1665	Notopterygium incisum	羌活	TCMH1665	JF755946
TCMH1798	Morus alba	桑枝	TCMH1798	ITSAL1073-14
TCMH776	Piper kadsura	海风藤	TCMH776	EF450290
TCMH1090	Brassica juncea	芥子	TCMH1090	ITSAJ4546-14
TCMH565	Stephania tetrandra	防己	TCMH565	ITSAG893-14
TCMH591	Impatiens balsamina	凤仙透骨草	TCMH591	ITSAD363-14
TCMH1889	Lycopodium japonicum	伸筋草	TCMH1889	KX302823
TCMH2166	Clematis chinensis	威灵仙	TCMH2166
TCMH183	Dryobalanops aromatica	冰片	TCMH183	GBVK4926-11
TCMH189	Mentholum	薄荷脑	TCMH189
TCMH2009	Methyl salicylatum	水杨酸甲酯	TCMH2009
TCMH2585	Cinnamomum camphora	樟脑	TCMH2585	SDH069-14
TCMH1881	NA	麝香草酚	TCMH1881
TCMH1880	Moschus moschiferus	麝香	TCMH1880	GBMA2112-09
TCMH472	Atropa belladonna	颠茄流浸膏	TCMH472	AY028147
TCMH2385	NA	盐酸苯海拉明	TCMH2385

Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID	Gene Symbol	Target Name	Target Class	Uniprot ID
TCMT100	TTR	Transthyretin	Unclassified	P02766
TCMT101	PTPN1	Protein-tyrosine phosphatase 1B	Hydrolase	P18031
TCMT107	GRIK2	Glutamate receptor ionotropic kainate 2	Ion channel	Q13002
TCMT109	GRIA2	Glutamate receptor ionotropic, AMPA 2	Ion channel	P42262
TCMT11	HIF1A	Hypoxia-inducible factor 1 alpha	Transcription factor	Q16665
TCMT110	GRIA4	Glutamate receptor ionotropic, AMPA 4	Ion channel	P48058
TCMT111	GRIK5	Glutamate receptor ionotropic kainate 5	Ion channel	Q16478
TCMT112	ADORA3	Adenosine A3 receptor	GPCR	P0DMS8
TCMT118	MGAM	Maltase-glucoamylase	Hydrolase	O43451
TCMT124	FUCA1	Alpha-L-fucosidase I	Hydrolase	P04066
TCMT125	GBA	Beta-glucocerebrosidase	Hydrolase	P04062
TCMT126	TERT	Telomerase reverse transcriptase	Transferase	O14746
TCMT127	PARP1	Poly [ADP-ribose] polymerase-1	Transferase	P09874
TCMT13	APEX1	DNA-(apurinic or apyrimidinic site) lyase	Lyase	P27695
TCMT130	ALOX5	Arachidonate 5-lipoxygenase	Oxidoreductase	P09917
TCMT131	ACHE	Acetylcholinesterase	Hydrolase	P22303
TCMT133	CA1	Carbonic anhydrase I	Lyase	P00915
TCMT134	CA2	Carbonic anhydrase II	Lyase	P00918
TCMT135	CA14	Carbonic anhydrase XIV	Lyase	Q9ULX7
TCMT136	CA12	Carbonic anhydrase XII	Lyase	O43570
TCMT137	CA9	Carbonic anhydrase IX	Lyase	Q16790
TCMT138	CA7	Carbonic anhydrase VII	Lyase	P43166
TCMT142	CA4	Carbonic anhydrase IV	Lyase	P22748
TCMT154	PRKCD	Protein kinase C delta	Kinase	Q05655
TCMT156	CYP19A1	Cytochrome P450 19A1	Oxidoreductase	P11511
TCMT159	TYR	Tyrosinase	Oxidoreductase	P14679
TCMT164	PTGS1	Cyclooxygenase-1	Oxidoreductase	P23219
TCMT17	POLB	DNA polymerase beta	Transferase	P06746
TCMT174	HSD11B1	11-beta-hydroxysteroid dehydrogenase 1	Oxidoreductase	P28845
TCMT18	GAA	Lysosomal alpha-glucosidase	Hydrolase	P10253
TCMT187	AR	Androgen Receptor	Nuclear receptor	P10275
TCMT189	DUSP3	Dual specificity protein phosphatase 3	Hydrolase	P51452
TCMT190	PTPN2	T-cell protein-tyrosine phosphatase	Hydrolase	P17706
TCMT197	PDE4D	Phosphodiesterase 4D	Hydrolase	Q08499
TCMT2	MAPT	Microtubule-associated protein tau	Unclassified	P10636
TCMT203	G6PD	Glucose-6-phosphate 1-dehydrogenase	Oxidoreductase	P11413
TCMT206	CYP2A6	Cytochrome P450 2A6	Oxidoreductase	P11509
TCMT207	BACE1	Beta-secretase 1	Protease	P56817
TCMT208	MAOA	Monoamine oxidase A	Oxidoreductase	P21397
TCMT212	SRC	Tyrosine-protein kinase SRC	Kinase	P12931
TCMT215	CYP1A1	Cytochrome P450 1A1	Oxidoreductase	P04798
TCMT217	CYP2C8	Cytochrome P450 2C8	Oxidoreductase	P10632
TCMT219	CYP1A2	Cytochrome P450 1A2	Oxidoreductase	P05177
TCMT220	CYP2J2	Cytochrome P450 2J2	Oxidoreductase	P51589
TCMT223	AKR1B1	Aldose reductase	Oxidoreductase	P15121
TCMT23	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	Hydrolase	P05186
TCMT230	HSD17B3	Estradiol 17-beta-dehydrogenase 3	Oxidoreductase	P37058
TCMT232	ABCB1	P-glycoprotein 1	Transporter	P08183
TCMT236	ESR2	Estrogen receptor beta	Nuclear receptor	Q92731
TCMT239	PIM1	Serine/threonine-protein kinase PIM1	Kinase	P11309
TCMT257	CYP1B1	Cytochrome P450 1B1	Oxidoreductase	Q16678
TCMT260	FLT3	Tyrosine-protein kinase receptor FLT3	Kinase	P36888
TCMT261	DAPK1	Death-associated protein kinase 1	Kinase	P53355
TCMT268	CYP2A13	Cytochrome P450 2A13	Oxidoreductase	Q16696
TCMT280	AKR1B10	Aldo-keto reductase family 1 member B10	Oxidoreductase	O60218
TCMT289	TBXAS1	Thromboxane-A synthase	Isomerase	P24557
TCMT290	CHRM5	Muscarinic acetylcholine receptor M5	GPCR	P08912
TCMT291	CHRM3	Muscarinic acetylcholine receptor M3	GPCR	P20309
TCMT292	CHRM1	Muscarinic acetylcholine receptor M1	GPCR	P11229
TCMT293	CHRM2	Muscarinic acetylcholine receptor M2	GPCR	P08172
TCMT295	MMP1	Matrix metalloproteinase-1	Hydrolase	P03956
TCMT296	ADORA1	Adenosine A1 receptor	GPCR	P30542
TCMT297	FABP4	Fatty acid binding protein adipocyte	Unclassified	P15090
TCMT298	FABP3	Fatty acid binding protein muscle	Hydrolase	P05413
TCMT30	PTGS2	Cyclooxygenase-2	Oxidoreductase	P35354
TCMT301	PTGES	Prostaglandin E synthase	Isomerase	O14684
TCMT302	HMGCR	HMG-CoA reductase	Oxidoreductase	P04035
TCMT304	MMP14	Matrix metalloproteinase 14	Hydrolase	P50281
TCMT306	MMP2	Matrix metalloproteinase-2	Hydrolase	P08253
TCMT320	MMP3	Matrix metalloproteinase 3	Hydrolase	P08254
TCMT321	MMP9	Matrix metalloproteinase 9	Hydrolase	P14780
TCMT322	MMP13	Matrix metalloproteinase 13	Hydrolase	P45452
TCMT327	TRPV1	Vanilloid receptor	Ion channel	Q8NER1
TCMT329	NQO2	Quinone reductase 2	Oxidoreductase	P16083
TCMT336	IDO1	Indoleamine 2,3-dioxygenase	Oxidoreductase	P14902
TCMT337	XPO1	Exportin-1	Unclassified	O14980
TCMT34	CYP2D6	Cytochrome P450 2D6	Oxidoreductase	P10635
TCMT344	AOX1	Aldehyde oxidase	Oxidoreductase	Q06278
TCMT347	MAN1B1	Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase	Hydrolase	Q9UKM7
TCMT354	AURKA	Serine/threonine-protein kinase Aurora-A	Kinase	O14965
TCMT369	IGF1R	Insulin-like growth factor I receptor	Kinase	P08069
TCMT370	KDR	Vascular endothelial growth factor receptor 2	Kinase	P35968
TCMT374	AURKB	Serine/threonine-protein kinase Aurora-B	Kinase	Q96GD4
TCMT377	INSR	Insulin receptor	Kinase	P06213
TCMT388	AXL	Tyrosine-protein kinase receptor UFO	Kinase	P30530
TCMT401	MET	Hepatocyte growth factor receptor	Kinase	P08581
TCMT407	MYLK	Myosin light chain kinase, smooth muscle	Kinase	Q15746
TCMT418	EPHB4	Ephrin type-B receptor 4	Kinase	P54760
TCMT422	CAMK2B	CaM kinase II beta	Kinase	Q13554
TCMT423	EGFR	Epidermal growth factor receptor erbB1	Kinase	P00533
TCMT436	NUAK1	NUAK family SNF1-like kinase 1	Kinase	O60285
TCMT44	GLO1	Glyoxalase I	Lyase	Q04760
TCMT445	NEK2	Serine/threonine-protein kinase NEK2	Kinase	P51955
TCMT45	APP	Beta amyloid A4 protein	Unclassified	P05067
TCMT457	FLT4	Vascular endothelial growth factor receptor 3	Kinase	P35916
TCMT46	F3	Coagulation factor III	Unclassified	P13726
TCMT462	NEK6	Serine/threonine-protein kinase NEK6	Kinase	Q9HC98
TCMT466	MAPK9	c-Jun N-terminal kinase 2	Kinase	P45984
TCMT47	BCL2	Apoptosis regulator Bcl-2	Ion channel	P10415
TCMT479	AKT1	Serine/threonine-protein kinase AKT	Kinase	P31749
TCMT484	PLK1	Serine/threonine-protein kinase PLK1	Kinase	P53350
TCMT502	TEK	Tyrosine-protein kinase TIE-2	Kinase	Q02763
TCMT536	PDGFRB	Platelet-derived growth factor receptor beta	Kinase	P09619
TCMT558	TOP2A	DNA topoisomerase II alpha	Isomerase	P11388
TCMT563	CDC25B	Dual specificity phosphatase Cdc25B	Hydrolase	P30305
TCMT565	EP300	Histone acetyltransferase p300	Transferase	Q09472
TCMT566	NOS2	Nitric oxide synthase, inducible	Oxidoreductase	P35228
TCMT567	DNMT1	DNA (cytosine-5)-methyltransferase 1	Transferase	P26358
TCMT570	ANPEP	Aminopeptidase N	Unclassified	P15144
TCMT571	ADORA2B	Adenosine A2b receptor	GPCR	P29275
TCMT588	DAO	D-amino-acid oxidase	Oxidoreductase	P14920
TCMT591	ESRRA	Estrogen-related receptor alpha	Nuclear receptor	P11474
TCMT592	XDH	Xanthine dehydrogenase	Oxidoreductase	P47989
TCMT594	PTAFR	Platelet activating factor receptor	GPCR	P25105
TCMT597	SLC28A3	Solute carrier family 28 member 3	Transporter	Q9HAS3
TCMT599	UBE2N	Ubiquitin-conjugating enzyme E2 N	Transferase	P61088
TCMT626	BRAF	Serine/threonine-protein kinase B-raf	Kinase	P15056
TCMT63	PPARA	Peroxisome proliferator-activated receptor alpha	Nuclear receptor	Q07869
TCMT636	POLA1	DNA polymerase alpha subunit	Transferase	P09884
TCMT637	SIRT3	NAD-dependent deacetylase sirtuin 3	Hydrolase	Q9NTG7
TCMT638	SIRT2	NAD-dependent deacetylase sirtuin 2	Hydrolase	Q8IXJ6
TCMT653	GRM1	Metabotropic glutamate receptor 1	GPCR	Q13255
TCMT654	GRM5	Metabotropic glutamate receptor 5	GPCR	P41594
TCMT655	GRM2	Metabotropic glutamate receptor 2	GPCR	Q14416
TCMT656	GRM3	Metabotropic glutamate receptor 3	GPCR	Q14832
TCMT657	GRM4	Metabotropic glutamate receptor 4	GPCR	Q14833
TCMT66	HSD17B2	Estradiol 17-beta-dehydrogenase 2	Oxidoreductase	P37059
TCMT660	GRM8	Metabotropic glutamate receptor 8	GPCR	O00222
TCMT664	SLC1A1	Excitatory amino acid transporter 3	Transporter	P43005
TCMT675	ADRB1	Beta-1 adrenergic receptor	GPCR	P08588
TCMT678	XIAP	Inhibitor of apoptosis protein 3	Transferase	P98170
TCMT679	MPEG1	Macrophage-expressed gene 1 protein	Unclassified	Q2M385
TCMT680	KAT2B	Histone acetyltransferase PCAF	Transferase	Q92831
TCMT683	MIF	Macrophage migration inhibitory factor	Isomerase	P14174
TCMT689	TGM2	Protein-glutamine gamma-glutamyltransferase	Transferase	P21980
TCMT698	PDE4B	Phosphodiesterase 4B	Hydrolase	Q07343
TCMT701	PTPN22	Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP	Hydrolase	Q9Y2R2
TCMT704	ERBB2	Receptor protein-tyrosine kinase erbB-2	Kinase	P04626
TCMT709	SLC28A2	Sodium/nucleoside cotransporter 2	Transporter	O43868
TCMT710	SLC28A1	Sodium/nucleoside cotransporter 1	Transporter	O00337
TCMT721	HSPA1A	Heat shock 70 kDa protein 1	Unclassified	P0DMV8
TCMT725	CACNA1C	Voltage-gated L-type calcium channel alpha-1C subunit	Ion channel	Q13936
TCMT729	PIK3CA	PI3-kinase p110-alpha subunit	Transferase	P42336
TCMT730	PIK3CB	PI3-kinase p110-beta subunit	Transferase	P42338
TCMT734	MMP12	Matrix metalloproteinase 12	Hydrolase	P39900
TCMT737	APOBEC3G	DNA dC->dU-editing enzyme APOBEC-3G	Unclassified	Q9HC16
TCMT739	GPR35	G-protein coupled receptor 35	GPCR	Q9HC97
TCMT740	PIK3CG	PI3-kinase p110-gamma subunit	Transferase	P48736
TCMT751	DYRK1A	Dual-specificity tyrosine-phosphorylation regulated kinase 1A	Kinase	Q13627
TCMT752	CSNK2A1	Casein kinase II alpha	Kinase	P68400
TCMT753	SMAD3	Mothers against decapentaplegic homolog 3	Unclassified	P84022
TCMT755	PLK4	Serine/threonine-protein kinase PLK4	Kinase	O00444
TCMT756	MAP3K8	Mitogen-activated protein kinase kinase kinase 8	Kinase	P41279
TCMT759	SAE1	SUMO-activating enzyme subunit 1	Unclassified	Q9UBE0
TCMT778	KCNA5	Voltage-gated potassium channel subunit Kv1.5	Ion channel	P22460
TCMT780	CACNA1D	Voltage-gated L-type calcium channel alpha-1D subunit	Ion channel	Q01668
TCMT781	CYP2E1	Cytochrome P450 2E1	Oxidoreductase	P05181
TCMT784	AVPR2	Vasopressin V2 receptor	GPCR	P30518
TCMT785	CXCR1	Interleukin-8 receptor A	GPCR	P25024
TCMT786	CCR4	C-C chemokine receptor type 4	GPCR	P51679
TCMT791	PKN1	Protein kinase N1	Kinase	Q16512
TCMT793	PYGL	Liver glycogen phosphorylase	Transferase	P06737
TCMT8	KDM4E	Lysine-specific demethylase 4D-like	Oxidoreductase	B2RXH2
TCMT807	SLC22A12	Solute carrier family 22 member 12	Transporter	Q96S37
TCMT808	FABP5	Fatty acid binding protein epidermal	Unclassified	Q01469
TCMT809	FABP2	Fatty acid binding protein intestinal	Unclassified	P12104
TCMT810	TLR2	Toll-like receptor 2	Unclassified	O60603
TCMT82	ESR1	Estrogen receptor alpha	Nuclear receptor	P03372
TCMT822	FUT7	Alpha-(1,3)-fucosyltransferase 7	Transferase	Q11130
TCMT83	CD38	Lymphocyte differentiation antigen CD38	Unclassified	P28907
TCMT87	CYP2C9	Cytochrome P450 2C9	Oxidoreductase	P11712
TCMT910	ESRRB	Estrogen-related receptor beta	Nuclear receptor	O95718
TCMT962	ENPP2	Autotaxin	Hydrolase	Q13822
TCMT974	GPER1	G-protein coupled estrogen receptor 1	GPCR	Q99527
TCMT99	SHBG	Testis-specific androgen-binding protein	Unclassified	P04278

Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID	Target Name
TCMT1170	Enterobacter cloacae
TCMT1172	Staphylococcus aureus subsp. aureus RN4220
TCMT1175	Human immunodeficiency virus
TCMT1176	Streptococcus pneumoniae
TCMT1178	Actinomyces viscosus
TCMT1179	Escherichia coli ATCC 8739
TCMT1181	Mycobacterium tuberculosis H37Ra
TCMT1182	Streptococcus sanguinis
TCMT1189	Pseudomonas fluorescens
TCMT1190	Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1208	Escherichia coli K12
TCMT1209	Staphylococcus haemolyticus
TCMT1210	Streptococcus sobrinus
TCMT1211	Fusobacterium nucleatum
TCMT1212	Verticillium dahliae
TCMT1213	Neisseria gonorrhoeae
TCMT1214	Enterococcus faecium
TCMT1215	Pseudomonas aeruginosa PAO1
TCMT1218	Staphylococcus aureus
TCMT1221	Human herpesvirus 4
TCMT1222	Plasmodium falciparum D6
TCMT1223	Staphylococcus epidermidis
TCMT1224	Proteus mirabilis
TCMT1226	Klebsiella pneumoniae
TCMT1229	Enterococcus faecalis
TCMT1231	Human herpesvirus 1 strain KOS
TCMT1232	Pseudomonas aeruginosa
TCMT1243	Aspergillus flavus
TCMT1245	Phytophthora cactorum
TCMT1246	Escherichia coli
TCMT1248	Hepatitis C virus
TCMT1249	Dengue virus 2
TCMT1251	Candida albicans
TCMT1253	Penicillium chrysogenum
TCMT1255	Human immunodeficiency virus 1
TCMT1282	Colletotrichum orbiculare
TCMT1286	Bacillus cereus
TCMT1289	Shigella dysenteriae
TCMT1293	Vaccinia virus
TCMT1294	Human parainfluenza virus 3
TCMT1313	Human immunodeficiency virus 2
TCMT1314	Streptococcus viridans
TCMT1321	Staphylococcus hominis
TCMT1343	Staphylococcus simulans
TCMT1344	Staphylococcus sciuri
TCMT1346	Helicobacter pylori
TCMT1349	Helicobacter pylori SS1
TCMT1361	Neisseria meningitidis
TCMT1370	Prevotella melaninogenica
TCMT1382	Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393	Vibrio sp.
TCMT1408	Colletotrichum gloeosporioides
TCMT1412	Salmonella typhimurium
TCMT1438	Plasmodium falciparum
TCMT1442	Leishmania donovani
TCMT1443	Leishmania amazonensis
TCMT1444	Fusarium oxysporum
TCMT1447	Respiratory syncytial virus
TCMT1448	Enterobacter aerogenes
TCMT1449	Influenza A virus
TCMT1450	Plasmodium falciparum 3D7
TCMT1454	Bacillus subtilis
TCMT1455	Mycobacterium tuberculosis H37Rv
TCMT1458	Filobasidiella neoformans
TCMT1462	Streptococcus mutans
TCMT1463	Mycobacterium tuberculosis
TCMT1464	Hepatitis B virus
TCMT1465	Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term	GO Name	Enriched Genes	Log10 Adjusted P-value

KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID	Enriched Genes	Log10 Adjusted P-value

Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset

Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples

Data Section	Select to Download
1. General Information of Prescription
2. Putative Targets
3. Activity & References for Filtering Putative Targets
4. GO & Pathway

TCM Prescription: Guan Jie Jie Tong Ointment