Prescription Description
| Prescription ID | TCMF2607 |
| Pinyin Name | Ding Kun Dan |
| Chinese Name | 定坤丹 |
| English Name | Dingkun Pills, Bolus for Woman Diseases |
| Function Description | 月经不调, 行经腹痛 |
| Indications | Abdominal pain disorder, Irregular menstruation |
| Disease ICD-11 Category |
SA58 [Abdominal pain disorder (TM1), 腹痛 (TM1)
]; GA20.3 [Abnormal regularity of uterine bleeding, 子宫出血周期异常 ]; |
| Human Tissues Associated with Indication | Uterus |
| Reference | Chinese Classical Prescriptions |
| Reference Book/link | ISBN 7-5023-3930-2 |
Prescription Components
| Component ID | Latin Name | Chinese Name | Component Quantity | Barcode |
|---|---|---|---|---|
| TCMH1721 | Panax ginseng | 人参 | TCMH1721 | GBVE1679-11 |
| TCMH1349 | Cervus elaphus | 鹿茸 | TCMH1349 | ABMC060-05 |
| TCMH2226 | Stigma croci | 西红花 | TCMH2226 | |
| TCMH1036 | Spatholobus suberectus | 鸡血藤 | TCMH1036 | ITSAK2607-14 |
| TCMH1768 | Panax notoginseng | 三七 | TCMH1768 | ITSAO2360-14 |
| TCMH104 | Paeonia lactiflora | 白芍 | TCMH104 | ITSAH2416-14 |
| TCMH1896 | Radix rehmanniae | 生地黄 | TCMH1896 | |
| TCMH421 | Angelica sinensis | 当归 | TCMH421 | ITSAF173-14 |
| TCMH120 | Atractylodes macrocephala | 白术 | TCMH120 | ITSAN4430-14 |
| TCMH1186 | Lycium chinense | 枸杞子 | TCMH1186 | ITSAO4545-14 |
| TCMH986 | Scutellaria baicalensis | 黄芩 | TCMH986 | ITSAP4211-14 |
| TCMH2265 | Cyperus rotundus | 香附 | TCMH2265 | GENG1049-15 |
| TCMH263 | Fructus leonuri | 茺蔚子 | TCMH263 | |
| TCMH305 | Cnidium officinale | 川芎 | TCMH305 | ITSAP4207-14 |
| TCMH1346 | Cornu cervi degelatinatum | 鹿角霜 | TCMH1346 | |
| TCMH541 | Colla corii asini | 阿胶 | TCMH541 | |
| TCMH2376 | Corydalis yanhusuo | 延胡索 | TCMH2376 |
Targeted Human Proteins by the Ingredients of Prescription
| Target ID | Gene Symbol | Target Name | Target Class | Uniprot ID |
|---|---|---|---|---|
| TCMT100 | TTR | Transthyretin | Unclassified | P02766 |
| TCMT101 | PTPN1 | Protein-tyrosine phosphatase 1B | Hydrolase | P18031 |
| TCMT112 | ADORA3 | Adenosine A3 receptor | GPCR | P0DMS8 |
| TCMT127 | PARP1 | Poly [ADP-ribose] polymerase-1 | Transferase | P09874 |
| TCMT128 | TNKS2 | Tankyrase-2 | Transferase | Q9H2K2 |
| TCMT129 | TNKS | Tankyrase-1 | Transferase | O95271 |
| TCMT130 | ALOX5 | Arachidonate 5-lipoxygenase | Oxidoreductase | P09917 |
| TCMT131 | ACHE | Acetylcholinesterase | Hydrolase | P22303 |
| TCMT133 | CA1 | Carbonic anhydrase I | Lyase | P00915 |
| TCMT134 | CA2 | Carbonic anhydrase II | Lyase | P00918 |
Showing 1 to 10 of 135 entries
Targeted Pathogenic Microbes by the Ingredients of Prescription
| Target ID | Target Name |
|---|---|
| TCMT1170 | Enterobacter cloacae |
| TCMT1172 | Staphylococcus aureus subsp. aureus RN4220 |
| TCMT1175 | Human immunodeficiency virus |
| TCMT1176 | Streptococcus pneumoniae |
| TCMT1178 | Actinomyces viscosus |
| TCMT1181 | Mycobacterium tuberculosis H37Ra |
| TCMT1182 | Streptococcus sanguinis |
| TCMT1186 | Plasmodium yoelii yoelii |
| TCMT1189 | Pseudomonas fluorescens |
| TCMT1190 | Plasmodium falciparum (isolate FcB1 / Columbia) |
Showing 1 to 10 of 80 entries
Gene Ontology Associated to Targeted Human Proteins
| GO Term | GO Name | Enriched Genes | Log10 Adjusted P-value |
|---|---|---|---|
| [BP] GO:0000302 | response to reactive oxygen species | AKR1B1, AXL, CYP1B1, EGFR, MMP9, SRC | 2.17241 |
| [BP] GO:0001101 | response to acid chemical | AKR1B1, EGFR, FABP3, HSD17B2, KDR, MMP2, PTGS2, SRC | 2.26716 |
| [BP] GO:0001503 | ossification | ALOX15, ALPL, EGFR, MMP2, MMP9, TEK | 3.03907 |
| [BP] GO:0001505 | regulation of neurotransmitter levels | ACHE, CYP1B1, DRD1, DRD2, DRD3, EGFR, HTR1A, INSR, PTGS2, SMAD3 | 4.54197 |
| [BP] GO:0001525 | angiogenesis | CYP1B1, KDR, MMP2, PIK3CA, PIK3CB, PTGS2, TEK | 2.11394 |
| [BP] GO:0001659 | None | ADORA1, DRD1, DRD2, HTR2A | 3.09758 |
| [BP] GO:0001666 | response to hypoxia | ADORA1, CYP1A1, DRD2, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK | 3.62641 |
| [BP] GO:0001676 | long-chain fatty acid metabolic process | ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGS1, PTGS2 | 7.94393 |
| [BP] GO:0001932 | regulation of protein phosphorylation | ADORA1, ADRA1A, ALOX15, CDC25B, DRD1, DRD2, DUSP3, EGFR, FABP4, FLT3, HTR2A, HTR2B, IGF1R, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH | 5.25268 |
| [BP] GO:0001934 | positive regulation of protein phosphorylation | ADORA1, ADRA1A, ALOX15, CDC25B, DRD2, EGFR, FLT3, HTR2A, HTR2B, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH | 5.22198 |
Showing 1 to 10 of 528 entries
KEGG Pathways Associated to Targeted Human Proteins
| KEGG Pathway ID | Enriched Genes | Log10 Adjusted P-value |
|---|---|---|
| ABC transporters_Homo sapiens_hsa02010 | ABCB1 | 0.6494 |
| Acute myeloid leukemia_Homo sapiens_hsa05221 | PIK3CA, FLT3, PIM1, PIK3CB | 3.2644 |
| Adherens junction_Homo sapiens_hsa04520 | PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R | 7.5226 |
| Adipocytokine signaling pathway_Homo sapiens_hsa04920 | PPARA | 0.5164 |
| Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | PIK3CA, PIK3CB, ADRA1A | 1.2871 |
| AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | SMAD3, PIK3CA, MMP2, PIM1, PIK3CB, F3 | 4.3964 |
| Alcoholism_Homo sapiens_hsa05034 | DRD1, DRD2 | 0.6297 |
| Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | PIK3CA, INSR, PIK3CB | 2.6404 |
| Amoebiasis_Homo sapiens_hsa05146 | PIK3CA, PIK3CB | 0.9602 |
| Amphetamine addiction_Homo sapiens_hsa05031 | DRD1 | 0.5299 |
Showing 1 to 10 of 174 entries
Target Exprsssion in Healthy Human Tissues (protein & mRNA level)
Protein expression data was from the "Human Proteome Map" datasetmRNA expression data was from the "GTEx" dataset
Average Target Expression (Fold Change) in Multiple Disease Conditions
Fold Change with Corresponding Normal SamplesClick each cell within the heatmap to access gene expression of individual patient samples