Description of the Component
Component ID |
TCMH238 |
Latin Name |
Dichroa febrifuga |
English Name |
Antifebrile dichroa |
Chinese Pinyin Name |
Chang Shan |
中文名 |
常山 |
TCM Properties |
Cold,Pungent,Bitter |
TCM Meridians |
Lung,Liver,Heart |
Therapeutic Class English |
Vomiting promotion |
Therapeutic Class Chinese |
涌吐 |
Functions |
expel phlegm and relieve malaria |
Toxicity |
Extremely Toxic |
Geo-authentic habitats (道地产区) |
Sichuan Province,Chongqing |
Reference |
Chinese Pharmacopoeia (2015) |
Barcode ID |
ITSAJ4406-14 |
Barcode Source |
BOLDSYSTEMS |
TCM Prescriptions with the Component
| Prescription ID | Prescription English Name | Prescription Chinese Name |
|---|---|---|
| TCMF2040 | Decoction of Seven Fine Drugs for Malaria | 截疟七宝饮 |
| TCMF4690 | Jie Nue Qi Bao Pills | 截疟七宝丸 |
| TCMF50 | Xin Su Ning Capsule | 心速宁胶囊 |
| TCMF5839 | Sheng Ji Bie Jia Pills | 圣济鳖甲丸 |
| TCMFx1937 | Powder of Concha Ostreae and Alismatis | 牡蛎泽泻散 |
| TCMFx4520 | Jiu Long Hua Feng Pills | 九龙化风丸 |
Showing 1 to 6 of 6 entries
Targeted Human Proteins by the Ingredient of Component
| Target ID | Gene Symbol | Target Name | Target Class | Uniprot ID |
|---|---|---|---|---|
| TCMT2 | MAPT | Microtubule-associated protein tau | Unclassified | P10636 |
| TCMT226 | PDPK1 | 3-phosphoinositide dependent protein kinase-1 | Kinase | O15530 |
| TCMT3 | ALOX15 | Arachidonate 15-lipoxygenase | Oxidoreductase | P16050 |
| TCMT31 | CYP2C19 | Cytochrome P450 2C19 | Oxidoreductase | P33261 |
| TCMT33 | CYP3A4 | Cytochrome P450 3A4 | Oxidoreductase | P08684 |
| TCMT739 | GPR35 | G-protein coupled receptor 35 | GPCR | Q9HC97 |
| TCMT827 | NQO1 | Quinone reductase 1) | Oxidoreductase | P15559 |
| TCMT87 | CYP2C9 | Cytochrome P450 2C9 | Oxidoreductase | P11712 |
Showing 1 to 8 of 8 entries
Targeted Pathogenic Microbes by the Ingredient of Component
| Target ID | Target Name |
|---|---|
| TCMT1382 | Plasmodium falciparum (isolate K1 / Thailand) |
| TCMT1438 | Plasmodium falciparum |
Showing 1 to 2 of 2 entries
Ingredient Structrues
Ingredient ID: TCMC5548
Formula: C16H19N3O3
Ingredient ID: TCMC5548
| Common Name | Α-Dichroine |
| IUPAC Name | 3-[[(2R,3aS,7aS)-2-hydroxy-3a,4,5,6,7,7a-hexahydro-3H-furo[3,2-b]pyridin-2-yl]methyl]quinazolin-4-one |
| Canonical SMILES | O=c1n(cnc2c1cccc2)C[C@]1(O)O[C@@H]2[C@H](C1)[NH2+]CCC2 |
| Standard InCHI | InChI=1S/C16H19N3O3/c20-15-11-4-1-2-5-12(11)18-10-19(15)9-16(21)8-13-14(22-16)6-3-7-17-13/h1-2,4-5,10,13-14,17,21H,3,6-9H2/p+1/t13-,14-,16+/m0/s1 |
| Standard InCHIKey | YLYLCQRQSRDSQR-OFQRWUPVSA-O |
| External Identifiers | ChEMBL [N/A]; PubChem [10968628]; |
| Reference of Component-Ingredient Pair | N/A |
Occurrence of the ingredient across TCM components
Ingredient ID: TCMC4974
Formula: C20H20O4
Ingredient ID: TCMC4974
| Common Name | Dichrin B,Licarin B |
| IUPAC Name | 5-[(3S)-7-methoxy-3-methyl-5-[(E)-prop-1-enyl]-2,3-dihydro-1-benzofuran-2-yl]-1,3-benzodioxole |
| Canonical SMILES | C/C=C/c1cc2c(c(c1)OC)OC([C@H]2C)c1ccc2c(c1)OCO2 |
| Standard InCHI | InChI=1S/C20H20O4/c1-4-5-13-8-15-12(2)19(24-20(15)18(9-13)21-3)14-6-7-16-17(10-14)23-11-22-16/h4-10,12,19H,11H2,1-3H3/b5-4+/t12-,19?/m0/s1 |
| Standard InCHIKey | DMMQXURQRMNSBM-SWDBHPRBSA-N |
| External Identifiers | ChEMBL [N/A]; PubChem [5384942]; |
| Reference of Component-Ingredient Pair | N/A |
Occurrence of the ingredient across TCM components
Ingredient ID: TCMC4490
Formula: C10H8O4
Ingredient ID: TCMC4490
| Common Name | 7-Hydroxy-8-Methoxycoumarin,Daphnetin-8-Methyl Ether |
| IUPAC Name | 7-hydroxy-8-methoxychromen-2-one |
| Canonical SMILES | COc1c(O)ccc2c1oc(=O)cc2 |
| Standard InCHI | InChI=1S/C10H8O4/c1-13-10-7(11)4-2-6-3-5-8(12)14-9(6)10/h2-5,11H,1H3 |
| Standard InCHIKey | HAQWEMHXSIRYBE-UHFFFAOYSA-N |
| External Identifiers | ChEMBL [CHEMBL2331585]; PubChem [5316302]; |
| Reference of Component-Ingredient Pair | 21082271 |
Occurrence of the ingredient across TCM components
Ingredient ID: TCMC3421
Formula: C15H12O4
Ingredient ID: TCMC3421
| Common Name | Hydrangenol |
| IUPAC Name | 8-hydroxy-3-(4-hydroxyphenyl)-3,4-dihydroisochromen-1-one |
| Canonical SMILES | Oc1ccc(cc1)C1OC(=O)c2c(C1)cccc2O |
| Standard InCHI | InChI=1S/C15H12O4/c16-11-6-4-9(5-7-11)13-8-10-2-1-3-12(17)14(10)15(18)19-13/h1-7,13,16-17H,8H2 |
| Standard InCHIKey | DGKDFNDHPXVXHW-UHFFFAOYSA-N |
| External Identifiers | ChEMBL [CHEMBL69299]; PubChem [119199]; |
| Reference of Component-Ingredient Pair | 21582163 |
Occurrence of the ingredient across TCM components
Ingredient ID: TCMC3170
Formula: C2CaO4
Ingredient ID: TCMC3170
| Common Name | Calcium Oxalate |
| IUPAC Name | calcium;oxalate |
| Canonical SMILES | [O-]C(=O)C(=O)[O-].[Ca+2] |
| Standard InCHI | InChI=1S/C2H2O4.Ca/c3-1(4)2(5)6;/h(H,3,4)(H,5,6);/q;+2/p-2 |
| Standard InCHIKey | QXDMQSPYEZFLGF-UHFFFAOYSA-L |
| External Identifiers | ChEMBL [CHEMBL3184709]; PubChem [33005]; |
| Reference of Component-Ingredient Pair | 29413701 |
Occurrence of the ingredient across TCM components
Ingredient ID: TCMC2393
Formula: C16H19N3O3
Ingredient ID: TCMC2393
| Common Name | Febrifugine |
| IUPAC Name | 3-[3-[(2S,3R)-3-hydroxypiperidin-2-yl]-2-oxopropyl]quinazolin-4-one |
| Canonical SMILES | O=C(Cn1cnc2c(c1=O)cccc2)C[C@@H]1NCCC[C@H]1O |
| Standard InCHI | InChI=1S/C16H19N3O3/c20-11(8-14-15(21)6-3-7-17-14)9-19-10-18-13-5-2-1-4-12(13)16(19)22/h1-2,4-5,10,14-15,17,21H,3,6-9H2/t14-,15+/m0/s1 |
| Standard InCHIKey | FWVHWDSCPKXMDB-LSDHHAIUSA-N |
| External Identifiers | ChEMBL [CHEMBL479432]; PubChem [63224]; |
| Reference of Component-Ingredient Pair | 22593757 |
Occurrence of the ingredient across TCM components
Ingredient ID: TCMC2232
Formula: C29H50O2
Ingredient ID: TCMC2232
| Common Name | Vitamin E |
| IUPAC Name | (2R)-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydrochromen-6-ol |
| Canonical SMILES | C[C@@H](CCC[C@]1(C)CCc2c(O1)c(C)c(c(c2C)O)C)CCC[C@@H](CCCC(C)C)C |
| Standard InCHI | InChI=1S/C29H50O2/c1-20(2)12-9-13-21(3)14-10-15-22(4)16-11-18-29(8)19-17-26-25(7)27(30)23(5)24(6)28(26)31-29/h20-22,30H,9-19H2,1-8H3/t21-,22-,29-/m1/s1 |
| Standard InCHIKey | GVJHHUAWPYXKBD-IEOSBIPESA-N |
| External Identifiers | ChEMBL [CHEMBL47]; PubChem [14985]; |
| Reference of Component-Ingredient Pair | 23122131 |
Occurrence of the ingredient across TCM components
| Component ID | Latin Name | Pinyin Name | Chinese Name |
|---|---|---|---|
| TCMH108 | Perilla frutescens | Bai Su Zi | 白苏子 |
| TCMH1090 | Brassica juncea | Jie Zi | 芥子 |
| TCMH1239 | Raphanus sativus | Lai Fu | 莱菔 |
| TCMH1240 | Raphanus sativus | Lai Fu Zi | 莱菔子 |
| TCMH1499 | Changium smyrnioides | Ming Dang Shen | 明党参 |
| TCMH1584 | Achyranthes bidentata | Niu Teng | 牛藤 |
| TCMH1588 | Achyranthes bidentata | Niu Xi | 牛膝 |
| TCMH1632 | Taraxacum mongolicum | Pu Gong Ying | 蒲公英 |
| TCMH1633 | Taraxacum mongolicum | Pu Gong Ying Jin Gao | 蒲公英浸膏 |
| TCMH1643 | Syzygium jambos | Pu Tao(1) | 蒲桃 |
Showing 1 to 10 of 47 entries
Ingredient ID: TCMC1991
Formula: C8H6N2O
Ingredient ID: TCMC1991
| Common Name | Quinazolinone |
| IUPAC Name | 1H-quinazolin-4-one |
| Canonical SMILES | Oc1ncnc2c1cccc2 |
| Standard InCHI | InChI=1S/C8H6N2O/c11-8-6-3-1-2-4-7(6)9-5-10-8/h1-5H,(H,9,10,11) |
| Standard InCHIKey | QMNUDYFKZYBWQX-UHFFFAOYSA-N |
| External Identifiers | ChEMBL [CHEMBL266540]; PubChem [63112]; |
| Reference of Component-Ingredient Pair | N/A |
Occurrence of the ingredient across TCM components
| Component ID | Latin Name | Pinyin Name | Chinese Name |
|---|---|---|---|
| TCMH126 | Isatis indigotica | Ban Lan | 板蓝 |
| TCMH127 | Isatis indigotica | Ban Lan Gen | 板蓝根 |
| TCMH1510 | Isatis indigotica | Mu Ban Lan Gen | 木板蓝根 |
| TCMH1512 | Isatis indigotica | Mu Da Qing Ye | 木大青叶 |
| TCMH238 | Dichroa febrifuga | Chang Shan | 常山 |
| TCMH381 | Isatis indigotica | Da Qing Ye | 大青叶 |
Showing 1 to 6 of 6 entries
Ingredient ID: TCMC1034
Formula: C19H12O6
Ingredient ID: TCMC1034
| Common Name | Dicumarol |
| IUPAC Name | 4-hydroxy-3-[(4-hydroxy-2-oxochromen-3-yl)methyl]chromen-2-one |
| Canonical SMILES | O=c1oc2ccccc2c(c1Cc1c(=O)oc2c(c1O)cccc2)O |
| Standard InCHI | InChI=1S/C19H12O6/c20-16-10-5-1-3-7-14(10)24-18(22)12(16)9-13-17(21)11-6-2-4-8-15(11)25-19(13)23/h1-8,20-21H,9H2 |
| Standard InCHIKey | DOBMPNYZJYQDGZ-UHFFFAOYSA-N |
| External Identifiers | ChEMBL [CHEMBL1466]; PubChem [54676038]; |
| Reference of Component-Ingredient Pair | N/A |
Occurrence of the ingredient across TCM components
Properties
| Ingredient ID | Formulae | Name | MW | AlogP | MlogP | XlogP | # HBA | # HBD | PSA | # Rotatable Bond | # Ring | # Heacy Atom | Lipinski RO5 Violation |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| TCMC1034 | C19H12O6 | Dicumarol | 336.06 | -0.3078 | 2.89 | 4.227 | 4 | 2 | 93.06 | 4 | 4 | 25 | 0 |
| TCMC1991 | C8H6N2O | Quinazolinone | 146.05 | -0.4603 | 2.01 | 1.634 | 2 | 1 | 46.01 | 1 | 2 | 11 | 0 |
| TCMC2232 | C29H50O2 | Vitamin E | 430.38 | 3.2935 | 4.43 | 10.938 | 0 | 1 | 29.46 | 21 | 2 | 31 | 2 |
| TCMC2393 | C16H19N3O3 | Febrifugine | 301.14 | -2.6457 | 2.56 | 1.543 | 6 | 2 | 82 | 5 | 3 | 22 | 0 |
| TCMC3170 | C2CaO4 | Calcium Oxalate | 87.97965848 | -1.8352 | 1.24 | -1.65 | 4 | 0 | 80.26 | 1 | 0 | 6 | 0 |
| TCMC3421 | C15H12O4 | Hydrangenol | 256.0735589 | -0.9997 | 2.67 | 3.342 | 2 | 2 | 66.76 | 1 | 3 | 19 | 0 |
| TCMC4490 | C10H8O4 | 7-Hydroxy-8-Methoxycoumarin,Daphnetin-8-Methyl Ether | 192.0422587 | -0.2698 | 2.12 | 0.375 | 1 | 1 | 46.53 | 1 | 2 | 14 | 0 |
| TCMC4974 | C20H20O4 | Dichrin B,Licarin B | 324.1361591 | 0.4817 | 3.22 | 4.809 | 0 | 0 | 36.92 | 3 | 4 | 24 | 0 |
| TCMC5548 | C16H19N3O3 | Α-Dichroine | 302.1504665 | -3.7729 | 2.56 | 1.012 | 5 | 2 | 75.5 | 2 | 4 | 22 | 0 |
Showing 1 to 9 of 9 entries
Download Data
All data can be downloaded by:→ Selecting data type in the below download table
→ Then click the download button.
