TCM Prescription: Jie Nue Qi Bao Pills



Prescription Description
Prescription IDTCMF4690
Pinyin NameJie Nue Qi Bao Wan
Chinese Name截疟七宝丸
English NameJie Nue Qi Bao Pills
Function Description积滞, 疟疾
IndicationsAlternating fever and chills disorder, Dyspepsia, Malaria
Disease ICD-11 Category SD93 [Alternating fever and chills disorder (TM1), ç–Ÿç–¾ (TM1) ];
MD92 [Dyspepsia, 消化不良 ];
1F45 [Malaria without parasitological confirmation, 疟疾，无寄生虫学证实(即临床诊断病例) ];
Human Tissues Associated with IndicationSpleen, Intestine, Stomach, Blood
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH238 Dichroa febrifuga 常山 TCMH238 ITSAJ4406-14
TCMH216 Fructus tsaoko 草果 TCMH216 GQ118666
TCMH182 Areca catechu 槟榔 TCMH182 ITSAA732-14
TCMH890 Cortex magnoliae officinalis 厚朴 TCMH890 ITSAM1591-14
TCMH1695 Pericarpium citri reticulatae viride 青皮 TCMH1695
TCMH243 Pericarpium citri reticulatae 陈皮 TCMH243
TCMH628 Glycyrrhiza uralensis 甘草 TCMH628 ITSAM892-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT114 CNR2 Cannabinoid CB2 receptor GPCR P34972
TCMT115 CNR1 Cannabinoid CB1 receptor GPCR P21554
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT231 GBA2 Beta-glucosidase Hydrolase Q9HCG7
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT289 TBXAS1 Thromboxane-A synthase Isomerase P24557
TCMT292 CHRM1 Muscarinic acetylcholine receptor M1 GPCR P11229
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT551 CHRM4 Muscarinic acetylcholine receptor M4 GPCR P08173
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT827 NQO1 Quinone reductase 1) Oxidoreductase P15559
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1183 Candida albicans SC5314
TCMT1186 Plasmodium yoelii yoelii
TCMT1189 Pseudomonas fluorescens
TCMT1201 Staphylococcus epidermidis ATCC 12228
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1243 Aspergillus flavus
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1292 Japanese encephalitis virus
TCMT1294 Human parainfluenza virus 3
TCMT1297 Punta Toro virus
TCMT1318 Human T-lymphotropic virus 1
TCMT1321 Staphylococcus hominis
TCMT1336 Yellow fever virus
TCMT1337 Dengue virus type 4
TCMT1338 Rift Valley fever virus
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2 8.54574
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 7.39389
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, TYR 7.15598
[BP] GO:0033993 response to lipid ALPL, BCL2, CA2, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, HSD11B2, HSD17B2, NQO1, TYR 7.15598
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, NQO1, TBXAS1, TYR, XDH 5.955
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7 5.90071
[BP] GO:0006629 lipid metabolic process ACHE, AKR1B1, AKR1B10, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, TBXAS1 5.34487
[BP] GO:0014070 response to organic cyclic compound ALPL, BCL2, CA2, CNR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, HSD11B2, NQO1, TYR 5.26146
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 5.25481
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 5.2337
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, BCL2, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, HSD11B2, HSD17B2, NQO1, TYR 5.09115
[BP] GO:0010817 regulation of hormone levels ACHE, AKR1B1, CNR1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.90662
[BP] GO:0065008 regulation of biological quality ACHE, AKR1B1, BCL2, CA12, CA2, CA7, CDK6, CHRM1, CNR1, CNR2, CYP19A1, CYP1A1, CYP1B1, ESR1, F3, GPR35, HSD11B1, HSD11B2, HSD17B1, HSD17B2, NQO1, TNKS, TNKS2, XDH 4.81138
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7 4.79676
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.41057
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, AOX1, CA1, CA12, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FUT7, GBA2, TBXAS1, TYR, XDH 4.29035
[BP] GO:0007197 None CHRM1, CHRM2, CHRM4 4.09873
[BP] GO:0007207 None CHRM1, CHRM2, CHRM4 3.82834
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.82684
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1, NQO1 3.82684
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.67409
[BP] GO:0007271 None CHRM1, CHRM2, CHRM4, NQO1 3.67409
[BP] GO:0010033 response to organic substance AKR1B1, ALPL, BCL2, CA2, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, HSD11B2, HSD17B2, NQO1, TYR 3.54618
[BP] GO:0032228 regulation of synaptic transmission, GABAergic CA2, CA7, CNR1, CNR2 3.39991
[BP] GO:0048513 animal organ development ACHE, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, HSD11B1, HSD17B2, TYR 3.24257
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.22898
[BP] GO:0009725 response to hormone AKR1B1, ALPL, BCL2, CA2, CSNK2A1, CYP1A2, ESR1, ESRRA, HSD11B2, NQO1 3.17843
[BP] GO:0008152 metabolic process ACHE, AKR1B1, AKR1B10, ALPL, AOX1, BCL2, CA1, CA12, CA2, CA4, CA7, CDC25B, CDK6, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, NQO1, PTPN1, TBXAS1, TNKS, TNKS2, TYR, XDH 3.09803
[BP] GO:0045759 None CNR1, CNR2, GPR35 2.99512
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, BCL2, CNR1, CNR2, CYP1A1, CYP1B1, NQO1 2.95151
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, CSNK2A1, CYP19A1, CYP1A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 2.91661
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.91661
[BP] GO:0072593 reactive oxygen species metabolic process BCL2, CYP1A1, CYP1A2, CYP1B1, NQO1 2.91436
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, BCL2, CYP19A1, CYP1A1, CYP1B1, GBA2, TYR 2.91436
[BP] GO:0032502 developmental process ACHE, AKR1B1, ALPL, BCL2, CA2, CDC25B, CDK6, CHRM1, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, FUT7, GBA2, HSD11B1, HSD17B2, NQO1, TNKS2, TYR 2.89673
[BP] GO:0009115 None AOX1, XDH 2.7766
[BP] GO:0048856 anatomical structure development ACHE, AKR1B1, ALPL, BCL2, CA2, CDK6, CHRM1, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, GBA2, HSD11B1, HSD17B2, TYR 2.7766
[BP] GO:0007213 None CHRM1, CHRM2, CHRM4 2.73035
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1A2, CYP1B1, TBXAS1 2.69515
[BP] GO:0016137 None AKR1B1, AKR1B10, GBA2 2.58751
[BP] GO:0042221 response to chemical AKR1B1, ALPL, BCL2, CA2, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, HSD11B2, HSD17B2, NQO1, TYR 2.50326
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.40439
[BP] GO:0046110 None AOX1, XDH 2.38712
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.38712
[BP] GO:0095500 None CHRM1, CHRM2, CHRM4 2.32399
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.32399
[BP] GO:1903831 None CHRM1, CHRM2, CHRM4 2.32399
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALPL, AOX1, BCL2, CA1, CA12, CA2, CA4, CA7, CDC25B, CDK6, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FUT7, GBA2, HSD17B1, HSD17B2, NQO1, PTPN1, TBXAS1, TNKS, TNKS2, TYR, XDH 2.31708
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AOX1, CYP1A1, CYP1A2, CYP1B1, NQO1 2.31508
[BP] GO:0031667 response to nutrient levels ALPL, BCL2, CNR1, CYP1A1, HSD11B2, NQO1, TYR 2.1631
[BP] GO:0042493 response to drug AKR1B1, BCL2, CDK6, CNR1, CNR2, CYP1A1, CYP1B1, HSD11B2, NQO1 2.1631
[BP] GO:0070213 None TNKS, TNKS2 2.1631
[BP] GO:0006145 None AOX1, XDH 2.1631
[BP] GO:0038171 None CNR1, CNR2 2.1631
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.1631
[BP] GO:0022900 electron transport chain AKR1B1, AOX1, CYP19A1, CYP1A2, XDH 2.1631
[BP] GO:0048522 positive regulation of cellular process ACHE, AKR1B1, BCL2, CA2, CA7, CDC25B, CDK6, CHRM1, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, GPR35, NQO1, PTPN1, TNKS, TNKS2, XDH 2.1339
[BP] GO:0010647 positive regulation of cell communication AKR1B1, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F3, GPR35, PTPN1, TNKS, TNKS2, XDH 2.04204
[BP] GO:0035265 organ growth BCL2, CYP19A1, ESR1 2.03764
[BP] GO:0023056 positive regulation of signaling AKR1B1, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F3, GPR35, PTPN1, TNKS, TNKS2, XDH 2.03189
[BP] GO:0007200 None CHRM1, CHRM2, CHRM4, ESR1 2.0315
[BP] GO:0009991 response to extracellular stimulus ALPL, BCL2, CNR1, CYP1A1, HSD11B2, NQO1, TYR 2.02142
[CC] GO:0005789 endoplasmic reticulum membrane BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, GBA2, HSD11B1, HSD11B2, HSD17B2, TBXAS1 2.16523
[CC] GO:0044432 endoplasmic reticulum part BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, GBA2, HSD11B1, HSD11B2, HSD17B2, PTPN1, TBXAS1 1.76504
[CC] GO:0016020 membrane ACHE, ALPL, BCL2, CA12, CA14, CA2, CA4, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, F3, FUT7, GBA2, GPR35, HSD11B1, HSD11B2, HSD17B2, PTPN1, TBXAS1, TNKS, TNKS2, TYR 1.65193
[CC] GO:0044425 membrane part ACHE, ALPL, BCL2, CA12, CA14, CA2, CA4, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, F3, FUT7, GBA2, GPR35, HSD11B1, HSD11B2, HSD17B2, PTPN1, TBXAS1, TYR 1.56235
[CC] GO:0044444 cytoplasmic part ACHE, AKR1B1, AKR1B10, AOX1, BCL2, CA1, CA2, CA4, CA7, CDC25B, CDK6, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, NQO1, PTPN1, TBXAS1, TNKS, TNKS2, TYR, XDH 1.34077
[MF] GO:0046914 transition metal ion binding AOX1, CA1, CA12, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, PTPN1, TBXAS1, TNKS, TYR, XDH 8.54574
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7 8.51894
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, NQO1, TBXAS1, TYR, XDH 7.15532
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, XDH 5.90071
[MF] GO:0003824 catalytic activity ACHE, AKR1B1, AKR1B10, ALPL, AOX1, CA1, CA12, CA14, CA2, CA4, CA7, CDC25B, CDK6, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, F3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, NQO1, PTPN1, TBXAS1, TNKS, TNKS2, TYR, XDH 5.90071
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7 5.38672
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7 4.79676
[MF] GO:0005496 steroid binding ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1 4.46211
[MF] GO:0005506 iron ion binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, TBXAS1, XDH 4.29035
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, TBXAS1, TYR 4.27426
[MF] GO:0016907 None CHRM1, CHRM2, CHRM4 4.09873
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.86256
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.79368
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.7063
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.67409
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.55567
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B2, HSD17B1, TBXAS1, XDH 3.30196
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, ESR1, ESR2, ESRRA, ESRRB, PTPN1, TNKS 3.24257
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, TBXAS1, TYR 3.24257
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.92832
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 2.91436
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7 2.91436
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, XDH 2.81845
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB 2.81767
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB 2.81767
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.7766
[MF] GO:0003845 None HSD11B1, HSD11B2 2.7766
[MF] GO:0043169 cation binding ACHE, ALPL, AOX1, CA1, CA12, CA14, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, PTPN1, TBXAS1, TNKS, TNKS2, TYR, XDH 2.73828
[MF] GO:0015464 None CHRM1, CHRM2, CHRM4 2.58751
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB 2.55958
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, TBXAS1 2.54515
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, TBXAS1 2.40439
[MF] GO:0004949 None CNR1, CNR2 2.38712
[MF] GO:0046872 metal ion binding ALPL, AOX1, CA1, CA12, CA14, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, PTPN1, TBXAS1, TNKS, TNKS2, TYR, XDH 2.37156
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.1631
[MF] GO:0043167 ion binding ACHE, ALPL, AOX1, CA1, CA12, CA14, CA2, CA4, CA7, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, HSD17B1, PTPN1, TBXAS1, TNKS, TNKS2, TYR, XDH 2.02094


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 10.433
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA14 10.4204
Metabolic pathways_Homo sapiens_hsa01100 AKR1B1, TYR, GBA2, CYP19A1, HSD11B1, FUT7, AKR1B10, HSD17B1, TBXAS1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH 6.2086
Ovarian steroidogenesis_Homo sapiens_hsa04913 HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1 5.7902
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1 4.5358
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, CHRM1, CHRM4, BCL2 4.2266
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, CHRM1, CNR2, GPR35, CNR1, CHRM4 3.5376
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP1A2, CYP1A1, CYP1B1 3.6284
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP1A2, CYP1A1, CYP1B1 3.5376
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1 2.516
MicroRNAs in cancer_Homo sapiens_hsa05206 CDK6, BCL2, CYP1B1, CDC25B 1.6998
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, CDK6, CHRM1, BCL2 1.513
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, TYR 1.8111
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, CHRM1, CHRM4 1.359
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.4655
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.8784
Prolactin signaling pathway_Homo sapiens_hsa04917 ESR1, ESR2 1.359
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.8111
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2, AOX1 1.359
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.0748
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.8548
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1 1.359
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 BCL2, F3 1.1886
Small cell lung cancer_Homo sapiens_hsa05222 CDK6, BCL2 1.2709
Estrogen signaling pathway_Homo sapiens_hsa04915 ESR1, ESR2 1.189
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2 1.2237
Measles_Homo sapiens_hsa05162 CDK6, CSNK2A1 1.0074
Hepatitis B_Homo sapiens_hsa05161 CDK6, BCL2 0.9776
Cell cycle_Homo sapiens_hsa04110 CDK6, CDC25B 1.0597
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, AOX1 0.9285
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, CHRM1 0.8633
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2 0.8294
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, CHRM1 0.8303
Pathways in cancer_Homo sapiens_hsa05200 CDK6, BCL2 0.5701
Glioma_Homo sapiens_hsa05214 CDK6 0.6507
Prostate cancer_Homo sapiens_hsa05215 BCL2 0.5981
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B 0.5815
Chronic myeloid leukemia_Homo sapiens_hsa05220 CDK6 0.643
Melanogenesis_Homo sapiens_hsa04916 TYR 0.5815
Pancreatic cancer_Homo sapiens_hsa05212 CDK6 0.6507
Melanoma_Homo sapiens_hsa05218 CDK6 0.6447
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5981
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.643
Insulin resistance_Homo sapiens_hsa04931 PTPN1 0.5701
HIF-1 signaling pathway_Homo sapiens_hsa04066 BCL2 0.5804
Non-small cell lung cancer_Homo sapiens_hsa05223 CDK6 0.6842
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 CNR1 0.5815
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5819
Colorectal cancer_Homo sapiens_hsa05210 BCL2 0.6598
Apoptosis_Homo sapiens_hsa04210 BCL2 0.5277
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5819
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 ESR1 0.5577
Neurotrophin signaling pathway_Homo sapiens_hsa04722 BCL2 0.5577
Platelet activation_Homo sapiens_hsa04611 TBXAS1 0.5571
Toxoplasmosis_Homo sapiens_hsa05145 BCL2 0.5577
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1 0.5277
Bile secretion_Homo sapiens_hsa04976 CA2 0.6447
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.4743
Sphingolipid signaling pathway_Homo sapiens_hsa04071 BCL2 0.5577
Tight junction_Homo sapiens_hsa04530 CSNK2A1 0.5277
Complement and coagulation cascades_Homo sapiens_hsa04610 F3 0.6242
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 ESRRB 0.5277
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.6447
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.5277
Peroxisome_Homo sapiens_hsa04146 XDH 0.6117
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2 0.5176
Purine metabolism_Homo sapiens_hsa00230 XDH 0.466
Arachidonic acid metabolism_Homo sapiens_hsa00590 TBXAS1 0.6598
Proteoglycans in cancer_Homo sapiens_hsa05205 ESR1 0.4362
Focal adhesion_Homo sapiens_hsa04510 BCL2 0.4362
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.3722
Viral carcinogenesis_Homo sapiens_hsa05203 CDK6 0.4362
Rap1 signaling pathway_Homo sapiens_hsa04015 CNR1 0.4311
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.4573
Tuberculosis_Homo sapiens_hsa05152 BCL2 0.466
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.7298
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.7138
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.7298
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.7298
Sphingolipid metabolism_Homo sapiens_hsa00600 GBA2 0.7298
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2 0.7781
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.8608
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8435
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.8608
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8633
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8633
Other glycan degradation_Homo sapiens_hsa00511 GBA2 0.9796
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.3881
Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 NQO1 1.1341
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.0597
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.3128


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)