Component: Polygonum bistorta 拳参


Description of the Component

Component ID
TCMH1708
Latin Name
Polygonum bistorta
English Name
Bistort
Chinese Pinyin Name
Quan Shen
中文名
拳参
TCM Properties
Cool,Bitter
TCM Meridians
Lung,Large Intestine,Liver
Therapeutic Class English
Heat clearence
Therapeutic Class Chinese
清热
Functions
remove toxic heat, promote the subsidence of swelling, and arrest bleeding
Toxicity
NA
Geo-authentic habitats (道地产区)
NA
Reference
Chinese Pharmacopoeia (2015)
Barcode ID
GQ434560
Barcode Source
GenBank

TCM Prescriptions with the Component

Prescription ID Prescription English Name Prescription Chinese Name
TCMF1987 Bawei Tanxiang Powder 八味檀香散
TCMF1307 Bawei Tanxiang Powder 八味檀香散
TCMFx1653 Cold-Fever-Treating Infusion 感冒退热冲剂
TCMF1779 Compound Oral Liquid of Isatis Leaf 复方大青叶合剂
TCMF1264 Compound Oral Liquid of Isatis Leaf 复方大青叶合剂
TCMFx3947 Dan Jia Tablets 胆荚片
TCMF3382 Fu Fang Da Qing Ye Granules 复方大青叶颗粒
TCMF3374 Fu Fang Da Qing Ye Recipe 复方大青叶合剂
TCMF3390 Fu Fang Da Qing Ye Shuan 复方大青叶栓
TCMF3398 Fu Fang Da Qing Ye Zhu She Oral Liquid 复方大青叶注射液
TCMFx3895 Fu Fang Quan Shen Tablets 复方拳参片
TCMFx3924 Fu Ke Wan Ying Ointment 妇科万应膏
TCMFx3849 Gan Mao Tui Shao Tablets 感冒退烧片
TCMF3666 Gan Yan Kang Fu Pills 肝炎康复丸
TCMF558 Gan Yan Kang Fu Pills 肝炎康复丸
TCMFx1694 Ganmao Tuire Granules 感冒退热颗粒
TCMFx1248 Ganmao Tuire Granules 感冒退热颗粒
TCMFx4453 Ke Yin Pills 克银丸
TCMFx4080 Li Xie Ling Tablets 痢泻灵片
TCMF5880 Qing Xue Nei Xiao Pills 清血内消丸
TCMFx490 Qing Yu Pi Wen Dan 庆余辟瘟丹
TCMFx5315 Quan Shen Tablets 拳参片
TCMF7114 Sha Shen Zhi Ke Tang Powder 沙参止咳汤散
TCMFx5041 She Shang Jie Du Tablets 蛇伤解毒片
TCMFx5358 Shen Nong Yao Wine 神农药酒
TCMFx174 Shi Liu Wei Dong Qing Pills 十六味冬青丸
TCMFx5114 Su Xiao Zhi Xie Capsules 速效止泻胶囊
TCMFx244 Xiao Er Fei Re Ping Capsule 小儿肺热平胶囊
TCMFx6650 Xiao Er Fei Re Ping Capsules 小儿肺热平胶囊
TCMFx7101 Xiao Er Shuang Qing Granules 小儿双清颗粒
TCMF1017 Yi Fei Qing Hua Ointment 益肺清化膏
TCMFx6730 Zhi Xue Tablets 止血片

Targeted Human Proteins by the Ingredient of Component

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT1 EHMT2 Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 Transferase Q96KQ7
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT143 CA3 Carbonic anhydrase III Lyase P07451
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT17 POLB DNA polymerase beta Transferase P06746
TCMT18 GAA Lysosomal alpha-glucosidase Hydrolase P10253
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT22 ALPI Intestinal alkaline phosphatase Hydrolase P09923
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT248 CXCL8 Interleukin-8 Unclassified P10145
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT41 IDH1 Isocitrate dehydrogenase [NADP] cytoplasmic Oxidoreductase O75874
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT6 NFKB1 Nuclear factor NF-kappa-B p105 subunit Transcription factor P19838
TCMT60 FASN Fatty acid synthase Unclassified P49327
TCMT601 F2 Thrombin Unclassified P00734
TCMT609 CTSL Cathepsin L Unclassified P07711
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT80 MAPK1 MAP kinase ERK2 Kinase P28482
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130


Targeted Pathogenic Microbes by the Ingredient of Component

Target ID Target Name
TCMT1175 Human immunodeficiency virus
TCMT1178 Actinomyces viscosus
TCMT1189 Pseudomonas fluorescens
TCMT1222 Plasmodium falciparum D6
TCMT1438 Plasmodium falciparum
TCMT1465 Entamoeba histolytica

Ingredient Structrues

Ingredient ID: TCMC913
Formula: C15H14O6

Ingredient ID: TCMC673
Formula: C29H50O2

Ingredient ID: TCMC6689
Formula: C20H20O14

Ingredient ID: TCMC4567
Formula: C13H16O10

Ingredient ID: TCMC2232
Formula: C29H50O2

Ingredient ID: TCMC13
Formula: C15H14O6

Ingredient ID: TCMC1202
Formula: C7H6O5

Properties

Ingredient ID Formulae Name MW AlogP MlogP XlogP # HBA # HBD PSA # Rotatable Bond # Ring # Heacy Atom Lipinski RO5 Violation
TCMC13 C15H14O6 (-)-Epicatechin 290.08 -2.494 2.45 0.406 1 5 110.38 6 3 21 0
TCMC673 C29H50O2 Alpha-Tochopherol 430.38 3.2935 4.43 10.938 0 1 29.46 21 2 31 2
TCMC913 C15H14O6 Cianidanol 290.08 -2.494 2.45 0.406 1 5 110.38 6 3 21 0
TCMC1202 C7H6O5 Gallic Acid 170.02 -1.6207 1.68 0.002 2 4 97.99 5 1 12 0
TCMC2232 C29H50O2 Vitamin E 430.38 3.2935 4.43 10.938 0 1 29.46 21 2 31 2
TCMC4567 C13H16O10 6-O-Galloyl-Glucose 332.0743467 -3.5251 1.79 -1.304 7 7 177.14 4 2 23 1
TCMC6689 C20H20O14 3,6-Di-O-Galloylglucose 484.0853053 -4.5368 2.12 -1.34 8 9 243.9 7 3 34 1

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1. General Information of the Component  
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3. Putative Targets  
4. Activity & References for Filtering Putative Targets  
5. Ingredient Data & Chemical Structure Information (Properties, InChI, InChIkey, SMILES, etc.)