Prescription Description
| Prescription ID | TCMF1264 |
| Pinyin Name | Fu Fang Da Qing Ye He Ji |
| Chinese Name | 复方大青叶合剂 |
| English Name | Compound Oral Liquid of Isatis Leaf |
| Function Description | 感冒, 痄腮, 胁痛, 黄疸 |
| Indications | Hypochondrium pain disorder, Jaundice disorder, Common cold disorder, Influenza, Mumps, Acute viral hepatitis |
| Disease ICD-11 Category |
SA00 [Hypochondrium pain disorder (TM1), 胁痛 (TM1)
]; SA01 [Jaundice disorder (TM1), 黄疸 (TM1) ]; SA60 [Common cold disorder (TM1), 感冒 (TM1) ]; 1E32 [Influenza, virus not identified, 季节性流行性感冒，病毒尚未鉴定 ]; 1D80 [Mumps, 腮腺炎 ]; 1E50 [Acute viral hepatitis, 急性病毒性肝炎 ]; |
| Human Tissues Associated with Indication | Heart, Lung,Liver, Lung, Blood |
| Reference | Chinese pharmacopoeia (2015) |
| Reference Book/link | ISBN 978-7-5067-7337-9 |
Prescription Components
| Component ID | Latin Name | Chinese Name | Component Quantity | Barcode |
|---|---|---|---|---|
| TCMH381 | Isatis indigotica | 大青叶 | TCMH381 | KJ765825 |
| TCMH1127 | Lonicera japonica | 金银花 | TCMH1127 | ITSAI3881-14 |
| TCMH1665 | Notopterygium incisum | 羌活 | TCMH1665 | JF755946 |
| TCMH1708 | Polygonum bistorta | 拳参 | TCMH1708 | GQ434560 |
| TCMH363 | Rheum officinale | 大黄 | TCMH363 | ITSAJ4685-14 |
Targeted Human Proteins by the Ingredients of Prescription
| Target ID | Gene Symbol | Target Name | Target Class | Uniprot ID |
|---|---|---|---|---|
| TCMT100 | TTR | Transthyretin | Unclassified | P02766 |
| TCMT102 | ACP1 | Low molecular weight phosphotyrosine protein phosphatase | Hydrolase | P24666 |
| TCMT103 | PTPRF | Receptor-type tyrosine-protein phosphatase F (LAR) | Hydrolase | P10586 |
| TCMT112 | ADORA3 | Adenosine A3 receptor | GPCR | P0DMS8 |
| TCMT114 | CNR2 | Cannabinoid CB2 receptor | GPCR | P34972 |
| TCMT115 | CNR1 | Cannabinoid CB1 receptor | GPCR | P21554 |
| TCMT127 | PARP1 | Poly [ADP-ribose] polymerase-1 | Transferase | P09874 |
| TCMT130 | ALOX5 | Arachidonate 5-lipoxygenase | Oxidoreductase | P09917 |
| TCMT131 | ACHE | Acetylcholinesterase | Hydrolase | P22303 |
| TCMT134 | CA2 | Carbonic anhydrase II | Lyase | P00918 |
Showing 1 to 10 of 105 entries
Targeted Pathogenic Microbes by the Ingredients of Prescription
| Target ID | Target Name |
|---|---|
| TCMT1170 | Enterobacter cloacae |
| TCMT1175 | Human immunodeficiency virus |
| TCMT1176 | Streptococcus pneumoniae |
| TCMT1178 | Actinomyces viscosus |
| TCMT1181 | Mycobacterium tuberculosis H37Ra |
| TCMT1182 | Streptococcus sanguinis |
| TCMT1183 | Candida albicans SC5314 |
| TCMT1189 | Pseudomonas fluorescens |
| TCMT1190 | Plasmodium falciparum (isolate FcB1 / Columbia) |
| TCMT1201 | Staphylococcus epidermidis ATCC 12228 |
Showing 1 to 10 of 63 entries
Gene Ontology Associated to Targeted Human Proteins
| GO Term | GO Name | Enriched Genes | Log10 Adjusted P-value |
|---|---|---|---|
| [BP] GO:0000302 | response to reactive oxygen species | AKR1B1, AXL, BCL2, CYP1B1, MMP9, SRC | 2.52825 |
| [BP] GO:0001101 | response to acid chemical | AKR1B1, DHFR, FABP3, HSD17B2, KDR, MMP2, PTGS2, SRC | 2.75353 |
| [BP] GO:0001503 | ossification | ALOX15, ALPL, BCL2, MMP2, MMP9 | 2.40044 |
| [BP] GO:0001662 | None | BCL2, HTR1A, HTR2C | 2.01853 |
| [BP] GO:0001666 | response to hypoxia | ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PTGS2, SRC | 2.5093 |
| [BP] GO:0001676 | long-chain fatty acid metabolic process | ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 | 4.84987 |
| [BP] GO:0001932 | regulation of protein phosphorylation | ADORA1, ALOX15, APP, AR, BCL2, FABP4, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, XDH | 3.7376 |
| [BP] GO:0001934 | positive regulation of protein phosphorylation | ADORA1, ALOX15, APP, AR, BCL2, FLT3, HTR2A, HTR2B, HTR2C, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, XDH | 4.46723 |
| [BP] GO:0001952 | regulation of cell-matrix adhesion | BCL2, GSK3B, KDR, PIK3CB, SRC | 2.55823 |
| [BP] GO:0002009 | morphogenesis of an epithelium | AR, BCL2, CA2, CA9, ESR1, MET, SRC | 2.32627 |
Showing 1 to 10 of 392 entries
KEGG Pathways Associated to Targeted Human Proteins
| KEGG Pathway ID | Enriched Genes | Log10 Adjusted P-value |
|---|---|---|
| Acute myeloid leukemia_Homo sapiens_hsa05221 | PIK3CA, FLT3, PIM1, PIK3CB | 3.5616 |
| Adherens junction_Homo sapiens_hsa04520 | CSNK2A1, SRC, MET, IGF1R | 3.2332 |
| Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | PIK3CA, BCL2, PIK3CB | 1.565 |
| African trypanosomiasis_Homo sapiens_hsa05143 | IDO1 | 0.841 |
| AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | PIK3CA, MMP2, BCL2, PIM1, PIK3CB | 3.776 |
| Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | HSD11B2, PIK3CA, PIK3CB, NR3C2 | 4.1499 |
| Alzheimer's disease_Homo sapiens_hsa05010 | GSK3B, APP | 0.8386 |
| Amoebiasis_Homo sapiens_hsa05146 | PIK3CA, PIK3CB | 1.1492 |
| AMPK signaling pathway_Homo sapiens_hsa04152 | PIK3CA, PIK3CB, IGF1R | 1.7279 |
| Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | BCL2 | 0.7135 |
Showing 1 to 10 of 151 entries
Target Exprsssion in Healthy Human Tissues (protein & mRNA level)
Protein expression data was from the "Human Proteome Map" datasetmRNA expression data was from the "GTEx" dataset
Average Target Expression (Fold Change) in Multiple Disease Conditions
Fold Change with Corresponding Normal SamplesClick each cell within the heatmap to access gene expression of individual patient samples