Component: Celastrus orbiculatus 南蛇藤


Description of the Component

Component ID
TCMH1545
Latin Name
Celastrus orbiculatus
English Name
Oriental bittersweet
Chinese Pinyin Name
Nan She Teng
中文名
南蛇藤
TCM Properties
TCM Meridians
Therapeutic Class English
Therapeutic Class Chinese
Functions
Toxicity
NA
Geo-authentic habitats (道地产区)
NA
Reference
Chinese Pharmacopoeia (2015)
Barcode ID
SDP690003-17, GBVX7729-15
Barcode Source
BOLDSYSTEMS

TCM Prescriptions with the Component

Prescription ID Prescription English Name Prescription Chinese Name
TCMF5164 San She Yao Wine 三蛇药酒

Targeted Human Proteins by the Ingredient of Component

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT1 EHMT2 Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 Transferase Q96KQ7
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT18 GAA Lysosomal alpha-glucosidase Hydrolase P10253
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT22 ALPI Intestinal alkaline phosphatase Hydrolase P09923
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT331 PLG Plasminogen Unclassified P00747
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT598 TOP1 DNA topoisomerase I Isomerase P11387
TCMT6 NFKB1 Nuclear factor NF-kappa-B p105 subunit Transcription factor P19838
TCMT60 FASN Fatty acid synthase Unclassified P49327
TCMT601 F2 Thrombin Unclassified P00734
TCMT609 CTSL Cathepsin L Unclassified P07711
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2


Targeted Pathogenic Microbes by the Ingredient of Component

Target ID Target Name
TCMT1175 Human immunodeficiency virus
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1438 Plasmodium falciparum
TCMT1463 Mycobacterium tuberculosis
TCMT1465 Entamoeba histolytica

Ingredient Structrues

Ingredient ID: TCMC882
Formula: C29H38O4

Ingredient ID: TCMC300
Formula: C15H14O5

Ingredient ID: TCMC2788
Formula: C31H36O7

Ingredient ID: TCMC2102
Formula: C21H20O12

Ingredient ID: TCMC13
Formula: C15H14O6

Properties

Ingredient ID Formulae Name MW AlogP MlogP XlogP # HBA # HBD PSA # Rotatable Bond # Ring # Heacy Atom Lipinski RO5 Violation
TCMC13 C15H14O6 (-)-Epicatechin 290.08 -2.494 2.45 0.406 1 5 110.38 6 3 21 0
TCMC300 C15H14O5 2-(4-Hydroxyphenyl)-3,4-Dihydro-2H-Chromene-3,5,7-Triol 274.08 -2.0337 2.56 0.94 1 4 90.15 5 3 20 0
TCMC882 C29H38O4 Celastrol 450.28 2.4831 4.21 7.98 4 2 74.6 9 5 33 1
TCMC2102 C21H20O12 Spiraeoside 464.1 -4.5481 2.45 -0.156 7 8 206.6 12 4 33 1
TCMC2788 C31H36O7 520.25 0.0632 4.1 8.582 7 0 88.13 13 5 38 1

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1. General Information of the Component  
2. TCM Prescriptions with the Component  
3. Putative Targets  
4. Activity & References for Filtering Putative Targets  
5. Ingredient Data & Chemical Structure Information (Properties, InChI, InChIkey, SMILES, etc.)