Prescription Description
| Prescription ID | TCMF1145 |
| Pinyin Name | Shu Feng Huo Luo Wan |
| Chinese Name | 疏风活络丸 |
| English Name | Shu Feng Huo Luo Pills |
| Function Description | 痹病 |
| Indications | Arthritis, Rheumatoid arthritis |
| Disease ICD-11 Category |
FA2Z [Inflammatory arthropathies, unspecified, 炎性关节病，未特指的
]; FA20 [Rheumatoid arthritis, 类风湿性关节炎 ]; |
| Human Tissues Associated with Indication | SkeletalMuscle, Blood |
| Reference | Chinese pharmacopoeia (2015) |
| Reference Book/link | ISBN 978-7-5067-7337-9 |
Prescription Components
| Component ID | Latin Name | Chinese Name | Component Quantity | Barcode |
|---|---|---|---|---|
| TCMH1405 | Strychnos nux-vomica | 马钱子 | TCMH1405 | PPBI045-16 |
| TCMH1398 | Ephedra sinica | 麻黄 | TCMH1398 | ITSAM882-14 |
| TCMH921 | Polygonum cuspidatum | 虎杖 | TCMH921 | ITSAI2369-14 |
| TCMH37 | Smilax china | 菝葜 | TCMH37 | CPBOL4044-11 |
| TCMH761 | Cinnamomum cassia | 桂枝 | TCMH761 | GQ255631 |
| TCMH1673 | Gentiana macrophylla | 秦艽 | TCMH1673 | ITSAO2245-14 |
| TCMH1518 | Chaenomeles sinensis | 木瓜 | TCMH1518 | GBVJ2053-11, GBVJ2052-11 |
| TCMH628 | Glycyrrhiza uralensis | 甘草 | TCMH628 | ITSAM892-14 |
| TCMH562 | Saposhnikovia divaricata | 防风 | TCMH562 | ITSAE3225-14 |
| TCMH1791 | Loranthus parasiticus | 桑寄生 | TCMH1791 |
Targeted Human Proteins by the Ingredients of Prescription
| Target ID | Gene Symbol | Target Name | Target Class | Uniprot ID |
|---|---|---|---|---|
| TCMT100 | TTR | Transthyretin | Unclassified | P02766 |
| TCMT101 | PTPN1 | Protein-tyrosine phosphatase 1B | Hydrolase | P18031 |
| TCMT102 | ACP1 | Low molecular weight phosphotyrosine protein phosphatase | Hydrolase | P24666 |
| TCMT103 | PTPRF | Receptor-type tyrosine-protein phosphatase F (LAR) | Hydrolase | P10586 |
| TCMT112 | ADORA3 | Adenosine A3 receptor | GPCR | P0DMS8 |
| TCMT127 | PARP1 | Poly [ADP-ribose] polymerase-1 | Transferase | P09874 |
| TCMT128 | TNKS2 | Tankyrase-2 | Transferase | Q9H2K2 |
| TCMT129 | TNKS | Tankyrase-1 | Transferase | O95271 |
| TCMT13 | APEX1 | DNA-(apurinic or apyrimidinic site) lyase | Lyase | P27695 |
| TCMT130 | ALOX5 | Arachidonate 5-lipoxygenase | Oxidoreductase | P09917 |
Showing 1 to 10 of 119 entries
Targeted Pathogenic Microbes by the Ingredients of Prescription
| Target ID | Target Name |
|---|---|
| TCMT1170 | Enterobacter cloacae |
| TCMT1175 | Human immunodeficiency virus |
| TCMT1176 | Streptococcus pneumoniae |
| TCMT1178 | Actinomyces viscosus |
| TCMT1179 | Escherichia coli ATCC 8739 |
| TCMT1181 | Mycobacterium tuberculosis H37Ra |
| TCMT1182 | Streptococcus sanguinis |
| TCMT1186 | Plasmodium yoelii yoelii |
| TCMT1189 | Pseudomonas fluorescens |
| TCMT1190 | Plasmodium falciparum (isolate FcB1 / Columbia) |
Showing 1 to 10 of 76 entries
Gene Ontology Associated to Targeted Human Proteins
| GO Term | GO Name | Enriched Genes | Log10 Adjusted P-value |
|---|---|---|---|
| [BP] GO:0000302 | response to reactive oxygen species | AKR1B1, APEX1, AXL, BCL2, CYP1B1, MMP9, PRKCD, SRC | 4.08183 |
| [BP] GO:0001101 | response to acid chemical | AKR1B1, BCHE, FABP3, HSD17B2, KDR, MMP2, PRKCE, PTGS2, SRC | 3.17616 |
| [BP] GO:0001505 | regulation of neurotransmitter levels | ACHE, BCHE, CYP1B1, PTGS2, SLC22A2, SLC22A3, TRPV1 | 2.30572 |
| [BP] GO:0001516 | None | MIF, PTGS1, PTGS2 | 2.81282 |
| [BP] GO:0001525 | angiogenesis | CYP1B1, KDR, MMP2, PIK3CA, PIK3CB, PRKCA, PTGS2 | 2.29765 |
| [BP] GO:0001666 | response to hypoxia | ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PRKCB, PRKCE, PTGS2, SRC | 4.73872 |
| [BP] GO:0001676 | long-chain fatty acid metabolic process | CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2 | 4.52514 |
| [BP] GO:0001775 | cell activation | ALOX5, AXL, BCL2, FLT3, FUT7, MIF, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, RORC, SRC, TRPV1 | 4.39168 |
| [BP] GO:0001932 | regulation of protein phosphorylation | ADORA1, BCL2, CDC25B, FABP4, FLT3, IGF1R, KDR, MIF, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, XDH | 3.09302 |
| [BP] GO:0001934 | positive regulation of protein phosphorylation | ADORA1, BCL2, CDC25B, FLT3, KDR, MIF, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, XDH | 3.83337 |
Showing 1 to 10 of 401 entries
KEGG Pathways Associated to Targeted Human Proteins
| KEGG Pathway ID | Enriched Genes | Log10 Adjusted P-value |
|---|---|---|
| Acute myeloid leukemia_Homo sapiens_hsa05221 | PIK3CA, FLT3, PIM1, PIK3CB | 3.5943 |
| Adherens junction_Homo sapiens_hsa04520 | PTPN1, CSNK2A1, SRC, MET, IGF1R | 4.3372 |
| Adipocytokine signaling pathway_Homo sapiens_hsa04920 | PPARA | 0.5857 |
| Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | PIK3CA, BCL2, PRKCA, PIK3CB | 2.2957 |
| African trypanosomiasis_Homo sapiens_hsa05143 | PRKCG, PRKCB, PRKCA | 3.0097 |
| AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | PIK3CA, PRKCB, MMP2, PRKCE, PRKCD, BCL2, PIM1, PRKCA, PIK3CB, F3 | 9.2619 |
| Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | PRKCG, PRKCB, PRKCE, PRKCA | 3.0753 |
| Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | PRKCG, HSD11B2, PIK3CA, PRKCB, PRKCA, PIK3CB | 7.0458 |
| Amoebiasis_Homo sapiens_hsa05146 | PRKCG, PIK3CA, PRKCB, PRKCA, PIK3CB | 3.7849 |
| Amphetamine addiction_Homo sapiens_hsa05031 | PRKCG, PRKCB, PRKCA | 2.3424 |
Showing 1 to 10 of 169 entries
Target Exprsssion in Healthy Human Tissues (protein & mRNA level)
Protein expression data was from the "Human Proteome Map" datasetmRNA expression data was from the "GTEx" dataset
Average Target Expression (Fold Change) in Multiple Disease Conditions
Fold Change with Corresponding Normal SamplesClick each cell within the heatmap to access gene expression of individual patient samples