Prescription ID | TCMF6763 |
Pinyin Name | Zi Yin Bu Shen Wan |
Chinese Name | 滋阴补肾丸 |
English Name | Zi Yin Bu Shen Pills |
Function Description | 腰痛, 遗精, 遗精, 阳痿, 早泄 |
Indications | Premature ejaculation disorder, Involuntary ejaculation disorder, Impotence disorder, Lumbago disorder, Sexual dysfunction, Lumbago, Premature ejaculation |
Disease ICD-11 Category |
SB08 [Premature ejaculation disorder (TM1), 早泄 (TM1)
]; SB09 [Involuntary ejaculation disorder (TM1), 遗精 (TM1) ]; SB0B [Impotence disorder (TM1), 阳痿 (TM1) ]; SC61 [Lumbago disorder (TM1), 腰痛 (TM1) ]; HA0Z [Sexual dysfunctions, unspecified, 性功能障碍,未特指的 ]; ME84.2Z [Low back pain, unspecified, 下腰痛,未特指的 ]; HA03.0Z [Male early ejaculation, unspecified, 男性早泄,未特指的 ]; |
Human Tissues Associated with Indication | Kidney, Bladder |
Reference | CFDA |
Reference Book/link | http://samr.cfda.gov.cn/WS01/CL0001/ |
Component ID | Latin Name | Chinese Name | Component Quantity | Barcode |
---|---|---|---|---|
TCMH1721 | Panax ginseng | 人参 | TCMH1721 | GBVE1679-11 |
TCMH1349 | Cervus elaphus | 鹿茸 | TCMH1349 | ABMC060-05 |
TCMH2202 | Schisandra chinensis | 五味子 | TCMH2202 | ITSAM2867-14 |
TCMH2149 | Cuscuta australis | 菟丝子 | TCMH2149 | ITSAP4209-14 |
TCMH2056 | Cynomorium songaricum | 锁阳 | TCMH2056 | ITSAO3649-14 |
TCMH2554 | Polygala tenuifolia | 远志 | TCMH2554 | MF096619 |
TCMH1845 | Dioscorea batatas | 山药 | TCMH1845 | |
TCMH1966 | Rehmannia glutinosa | 熟地黄 | TCMH1966 | ITSAH4578-14 |
TCMH451 | Rehmannia glutinosa | 地黄 | TCMH451 | ITSAH4578-14 |
TCMH981 | Astragalus membranaceus | 黄芪 | TCMH981 | ITSAK2981-14 |
TCMH31 | Morinda officinalis | 巴戟天 | TCMH31 | ITSAJ4459-14 |
TCMH1862 | Cornus officinalis | 山茱萸 | TCMH1862 | ITSAO2979-14 |
TCMH1321 | Os draconis | 龙骨 | TCMH1321 | |
TCMH909 | Trigonella foenum -graecum | 葫芦巴 | TCMH909 | |
TCMH1405 | Strychnos nux-vomica | 马钱子 | TCMH1405 | PPBI045-16 |
Target ID | Gene Symbol | Target Name | Target Class | Uniprot ID |
---|---|---|---|---|
TCMT101 | PTPN1 | Protein-tyrosine phosphatase 1B | Hydrolase | P18031 |
TCMT102 | ACP1 | Low molecular weight phosphotyrosine protein phosphatase | Hydrolase | P24666 |
TCMT103 | PTPRF | Receptor-type tyrosine-protein phosphatase F (LAR) | Hydrolase | P10586 |
TCMT107 | GRIK2 | Glutamate receptor ionotropic kainate 2 | Ion channel | Q13002 |
TCMT109 | GRIA2 | Glutamate receptor ionotropic, AMPA 2 | Ion channel | P42262 |
TCMT110 | GRIA4 | Glutamate receptor ionotropic, AMPA 4 | Ion channel | P48058 |
TCMT111 | GRIK5 | Glutamate receptor ionotropic kainate 5 | Ion channel | Q16478 |
TCMT112 | ADORA3 | Adenosine A3 receptor | GPCR | P0DMS8 |
TCMT130 | ALOX5 | Arachidonate 5-lipoxygenase | Oxidoreductase | P09917 |
TCMT131 | ACHE | Acetylcholinesterase | Hydrolase | P22303 |
TCMT133 | CA1 | Carbonic anhydrase I | Lyase | P00915 |
TCMT134 | CA2 | Carbonic anhydrase II | Lyase | P00918 |
TCMT135 | CA14 | Carbonic anhydrase XIV | Lyase | Q9ULX7 |
TCMT136 | CA12 | Carbonic anhydrase XII | Lyase | O43570 |
TCMT137 | CA9 | Carbonic anhydrase IX | Lyase | Q16790 |
TCMT138 | CA7 | Carbonic anhydrase VII | Lyase | P43166 |
TCMT142 | CA4 | Carbonic anhydrase IV | Lyase | P22748 |
TCMT150 | RORC | Nuclear receptor ROR-gamma | Nuclear receptor | P51449 |
TCMT156 | CYP19A1 | Cytochrome P450 19A1 | Oxidoreductase | P11511 |
TCMT159 | TYR | Tyrosinase | Oxidoreductase | P14679 |
TCMT161 | HCAR2 | Hydroxycarboxylic acid receptor 2 | GPCR | Q8TDS4 |
TCMT162 | UGT1A1 | UDP-glucuronosyltransferase 1-1 | Transferase | P22309 |
TCMT164 | PTGS1 | Cyclooxygenase-1 | Oxidoreductase | P23219 |
TCMT174 | HSD11B1 | 11-beta-hydroxysteroid dehydrogenase 1 | Oxidoreductase | P28845 |
TCMT190 | PTPN2 | T-cell protein-tyrosine phosphatase | Hydrolase | P17706 |
TCMT197 | PDE4D | Phosphodiesterase 4D | Hydrolase | Q08499 |
TCMT212 | SRC | Tyrosine-protein kinase SRC | Kinase | P12931 |
TCMT215 | CYP1A1 | Cytochrome P450 1A1 | Oxidoreductase | P04798 |
TCMT217 | CYP2C8 | Cytochrome P450 2C8 | Oxidoreductase | P10632 |
TCMT219 | CYP1A2 | Cytochrome P450 1A2 | Oxidoreductase | P05177 |
TCMT223 | AKR1B1 | Aldose reductase | Oxidoreductase | P15121 |
TCMT23 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | Hydrolase | P05186 |
TCMT239 | PIM1 | Serine/threonine-protein kinase PIM1 | Kinase | P11309 |
TCMT240 | AMY1A | Salivary alpha-amylase | Unclassified | P04745 |
TCMT254 | CBR1 | Carbonyl reductase [NADPH] 1 | Oxidoreductase | P16152 |
TCMT257 | CYP1B1 | Cytochrome P450 1B1 | Oxidoreductase | Q16678 |
TCMT260 | FLT3 | Tyrosine-protein kinase receptor FLT3 | Kinase | P36888 |
TCMT261 | DAPK1 | Death-associated protein kinase 1 | Kinase | P53355 |
TCMT280 | AKR1B10 | Aldo-keto reductase family 1 member B10 | Oxidoreductase | O60218 |
TCMT295 | MMP1 | Matrix metalloproteinase-1 | Hydrolase | P03956 |
TCMT296 | ADORA1 | Adenosine A1 receptor | GPCR | P30542 |
TCMT297 | FABP4 | Fatty acid binding protein adipocyte | Unclassified | P15090 |
TCMT298 | FABP3 | Fatty acid binding protein muscle | Hydrolase | P05413 |
TCMT3 | ALOX15 | Arachidonate 15-lipoxygenase | Oxidoreductase | P16050 |
TCMT30 | PTGS2 | Cyclooxygenase-2 | Oxidoreductase | P35354 |
TCMT302 | HMGCR | HMG-CoA reductase | Oxidoreductase | P04035 |
TCMT306 | MMP2 | Matrix metalloproteinase-2 | Hydrolase | P08253 |
TCMT321 | MMP9 | Matrix metalloproteinase 9 | Hydrolase | P14780 |
TCMT322 | MMP13 | Matrix metalloproteinase 13 | Hydrolase | P45452 |
TCMT327 | TRPV1 | Vanilloid receptor | Ion channel | Q8NER1 |
TCMT329 | NQO2 | Quinone reductase 2 | Oxidoreductase | P16083 |
TCMT33 | CYP3A4 | Cytochrome P450 3A4 | Oxidoreductase | P08684 |
TCMT34 | CYP2D6 | Cytochrome P450 2D6 | Oxidoreductase | P10635 |
TCMT369 | IGF1R | Insulin-like growth factor I receptor | Kinase | P08069 |
TCMT370 | KDR | Vascular endothelial growth factor receptor 2 | Kinase | P35968 |
TCMT374 | AURKB | Serine/threonine-protein kinase Aurora-B | Kinase | Q96GD4 |
TCMT388 | AXL | Tyrosine-protein kinase receptor UFO | Kinase | P30530 |
TCMT401 | MET | Hepatocyte growth factor receptor | Kinase | P08581 |
TCMT422 | CAMK2B | CaM kinase II beta | Kinase | Q13554 |
TCMT445 | NEK2 | Serine/threonine-protein kinase NEK2 | Kinase | P51955 |
TCMT45 | APP | Beta amyloid A4 protein | Unclassified | P05067 |
TCMT462 | NEK6 | Serine/threonine-protein kinase NEK6 | Kinase | Q9HC98 |
TCMT47 | BCL2 | Apoptosis regulator Bcl-2 | Ion channel | P10415 |
TCMT479 | AKT1 | Serine/threonine-protein kinase AKT | Kinase | P31749 |
TCMT484 | PLK1 | Serine/threonine-protein kinase PLK1 | Kinase | P53350 |
TCMT508 | SYK | Tyrosine-protein kinase SYK | Kinase | P43405 |
TCMT560 | F10 | Coagulation factor X | Unclassified | P00742 |
TCMT563 | CDC25B | Dual specificity phosphatase Cdc25B | Hydrolase | P30305 |
TCMT592 | XDH | Xanthine dehydrogenase | Oxidoreductase | P47989 |
TCMT597 | SLC28A3 | Solute carrier family 28 member 3 | Transporter | Q9HAS3 |
TCMT599 | UBE2N | Ubiquitin-conjugating enzyme E2 N | Transferase | P61088 |
TCMT613 | NR3C1 | Glucocorticoid receptor | Nuclear receptor | P04150 |
TCMT614 | EGLN1 | Egl nine homolog 1 | Oxidoreductase | Q9GZT9 |
TCMT63 | PPARA | Peroxisome proliferator-activated receptor alpha | Nuclear receptor | Q07869 |
TCMT65 | HSD17B1 | Estradiol 17-beta-dehydrogenase 1 | Oxidoreductase | P14061 |
TCMT653 | GRM1 | Metabotropic glutamate receptor 1 | GPCR | Q13255 |
TCMT654 | GRM5 | Metabotropic glutamate receptor 5 | GPCR | P41594 |
TCMT655 | GRM2 | Metabotropic glutamate receptor 2 | GPCR | Q14416 |
TCMT656 | GRM3 | Metabotropic glutamate receptor 3 | GPCR | Q14832 |
TCMT657 | GRM4 | Metabotropic glutamate receptor 4 | GPCR | Q14833 |
TCMT66 | HSD17B2 | Estradiol 17-beta-dehydrogenase 2 | Oxidoreductase | P37059 |
TCMT660 | GRM8 | Metabotropic glutamate receptor 8 | GPCR | O00222 |
TCMT664 | SLC1A1 | Excitatory amino acid transporter 3 | Transporter | P43005 |
TCMT698 | PDE4B | Phosphodiesterase 4B | Hydrolase | Q07343 |
TCMT709 | SLC28A2 | Sodium/nucleoside cotransporter 2 | Transporter | O43868 |
TCMT710 | SLC28A1 | Sodium/nucleoside cotransporter 1 | Transporter | O00337 |
TCMT729 | PIK3CA | PI3-kinase p110-alpha subunit | Transferase | P42336 |
TCMT730 | PIK3CB | PI3-kinase p110-beta subunit | Transferase | P42338 |
TCMT752 | CSNK2A1 | Casein kinase II alpha | Kinase | P68400 |
TCMT771 | ATR | Serine-protein kinase ATR | Kinase | Q13535 |
TCMT784 | AVPR2 | Vasopressin V2 receptor | GPCR | P30518 |
TCMT785 | CXCR1 | Interleukin-8 receptor A | GPCR | P25024 |
TCMT786 | CCR4 | C-C chemokine receptor type 4 | GPCR | P51679 |
TCMT791 | PKN1 | Protein kinase N1 | Kinase | Q16512 |
TCMT793 | PYGL | Liver glycogen phosphorylase | Transferase | P06737 |
TCMT808 | FABP5 | Fatty acid binding protein epidermal | Unclassified | Q01469 |
TCMT809 | FABP2 | Fatty acid binding protein intestinal | Unclassified | P12104 |
TCMT81 | ALOX12 | Arachidonate 12-lipoxygenase | Oxidoreductase | P18054 |
TCMT810 | TLR2 | Toll-like receptor 2 | Unclassified | O60603 |
TCMT82 | ESR1 | Estrogen receptor alpha | Nuclear receptor | P03372 |
TCMT822 | FUT7 | Alpha-(1,3)-fucosyltransferase 7 | Transferase | Q11130 |
TCMT848 | ERN1 | Serine/threonine-protein kinase/endoribonuclease IRE1 | Kinase | O75460 |
TCMT87 | CYP2C9 | Cytochrome P450 2C9 | Oxidoreductase | P11712 |
TCMT907 | FDPS | Farnesyl diphosphate synthase | Lyase | P14324 |
Target ID | Target Name |
---|---|
TCMT1170 | Enterobacter cloacae |
TCMT1172 | Staphylococcus aureus subsp. aureus RN4220 |
TCMT1175 | Human immunodeficiency virus |
TCMT1176 | Streptococcus pneumoniae |
TCMT1178 | Actinomyces viscosus |
TCMT1179 | Escherichia coli ATCC 8739 |
TCMT1180 | Human herpesvirus 2 |
TCMT1181 | Mycobacterium tuberculosis H37Ra |
TCMT1182 | Streptococcus sanguinis |
TCMT1189 | Pseudomonas fluorescens |
TCMT1191 | Bacillus megaterium |
TCMT1208 | Escherichia coli K12 |
TCMT1209 | Staphylococcus haemolyticus |
TCMT1212 | Verticillium dahliae |
TCMT1213 | Neisseria gonorrhoeae |
TCMT1214 | Enterococcus faecium |
TCMT1215 | Pseudomonas aeruginosa PAO1 |
TCMT1217 | Bacillus anthracis |
TCMT1218 | Staphylococcus aureus |
TCMT1222 | Plasmodium falciparum D6 |
TCMT1223 | Staphylococcus epidermidis |
TCMT1226 | Klebsiella pneumoniae |
TCMT1227 | Streptococcus |
TCMT1229 | Enterococcus faecalis |
TCMT1232 | Pseudomonas aeruginosa |
TCMT1236 | Mycobacterium bovis |
TCMT1243 | Aspergillus flavus |
TCMT1245 | Phytophthora cactorum |
TCMT1246 | Escherichia coli |
TCMT1247 | Human herpesvirus 1 |
TCMT1248 | Hepatitis C virus |
TCMT1250 | Vesicular stomatitis virus |
TCMT1251 | Candida albicans |
TCMT1253 | Penicillium chrysogenum |
TCMT1255 | Human immunodeficiency virus 1 |
TCMT1260 | Streptococcus agalactiae |
TCMT1282 | Colletotrichum orbiculare |
TCMT1284 | Penicillium expansum |
TCMT1286 | Bacillus cereus |
TCMT1289 | Shigella dysenteriae |
TCMT1292 | Japanese encephalitis virus |
TCMT1294 | Human parainfluenza virus 3 |
TCMT1319 | Corynebacterium xerosis |
TCMT1322 | Streptococcus mitis |
TCMT1323 | Corynebacterium pseudodiphtheriticum |
TCMT1324 | Corynebacterium diphtheriae |
TCMT1336 | Yellow fever virus |
TCMT1337 | Dengue virus type 4 |
TCMT1338 | Rift Valley fever virus |
TCMT1346 | Helicobacter pylori |
TCMT1349 | Helicobacter pylori SS1 |
TCMT1361 | Neisseria meningitidis |
TCMT1382 | Plasmodium falciparum (isolate K1 / Thailand) |
TCMT1393 | Vibrio sp. |
TCMT1408 | Colletotrichum gloeosporioides |
TCMT1410 | Listeria monocytogenes |
TCMT1412 | Salmonella typhimurium |
TCMT1438 | Plasmodium falciparum |
TCMT1439 | Mycobacterium smegmatis |
TCMT1442 | Leishmania donovani |
TCMT1443 | Leishmania amazonensis |
TCMT1447 | Respiratory syncytial virus |
TCMT1448 | Enterobacter aerogenes |
TCMT1449 | Influenza A virus |
TCMT1450 | Plasmodium falciparum 3D7 |
TCMT1454 | Bacillus subtilis |
TCMT1455 | Mycobacterium tuberculosis H37Rv |
TCMT1458 | Filobasidiella neoformans |
TCMT1462 | Streptococcus mutans |
TCMT1463 | Mycobacterium tuberculosis |
TCMT1464 | Hepatitis B virus |
TCMT1465 | Entamoeba histolytica |
GO Term | GO Name | Enriched Genes | Log10 Adjusted P-value |
---|---|---|---|
[BP] GO:0006629 | lipid metabolic process | ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APP, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, ESR1, FABP3, FABP4, FDPS, FUT7, HMGCR, HSD11B1, HSD17B1, HSD17B2, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, TRPV1 | 15.6373 |
[BP] GO:0065008 | regulation of biological quality | ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, APP, AURKB, AXL, BCL2, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, F10, FABP3, FABP4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HCAR2, HMGCR, HSD11B1, HSD17B1, HSD17B2, KDR, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, SLC1A1, SRC, TRPV1, XDH | 11.2799 |
[BP] GO:0008202 | steroid metabolic process | AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, ESR1, FDPS, HMGCR, HSD11B1, HSD17B1, HSD17B2 | 10.3953 |
[BP] GO:1901700 | response to oxygen-containing compound | AKR1B1, ALPL, APP, AXL, BCL2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, GRIK5, GRM5, HMGCR, HSD17B2, IGF1R, MMP2, MMP9, NR3C1, PIK3CA, PPARA, PTGS2, RORC, SRC, TRPV1, TYR | 10.3953 |
[BP] GO:0044281 | small molecule metabolic process | AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APP, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, FABP3, FDPS, FUT7, HMGCR, PIK3CA, PIM1, PPARA, PTGS1, PTGS2, TYR, XDH | 10.0585 |
[BP] GO:0044255 | cellular lipid metabolic process | ACHE, AKR1B10, ALOX12, ALOX15, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, FABP3, FABP4, FDPS, FUT7, HMGCR, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2 | 9.51469 |
[BP] GO:0010033 | response to organic substance | AKR1B1, ALOX15, ALPL, APP, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FLT3, GRIK5, GRM5, HMGCR, HSD17B2, IGF1R, KDR, MMP2, NR3C1, PIK3CA, PPARA, PTGS2, RORC, SRC, TRPV1, TYR | 9.40139 |
[BP] GO:0019369 | arachidonic acid metabolic process | ALOX12, ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, PTGS1, PTGS2 | 9.29176 |
[BP] GO:0033559 | unsaturated fatty acid metabolic process | ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, PTGS1, PTGS2 | 8.58071 |
[BP] GO:0055114 | oxidation-reduction process | AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, HMGCR, HSD11B1, HSD17B1, HSD17B2, NQO2, PTGS1, PTGS2, TYR, XDH | 8.4205 |
[BP] GO:0007215 | None | APP, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 | 8.4205 |
[BP] GO:0006690 | icosanoid metabolic process | ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, PTGS1, PTGS2 | 8.35641 |
[BP] GO:0008610 | lipid biosynthetic process | ACHE, AKR1B1, ALOX12, ALOX15, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, FDPS, HMGCR, HSD11B1, HSD17B1, HSD17B2, PIK3CA, PIK3CB, PTGS1, PTGS2 | 8.10398 |
[BP] GO:0042221 | response to chemical | AKR1B1, ALOX15, ALPL, APP, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FLT3, GRIK5, GRM5, HMGCR, HSD17B2, IGF1R, KDR, MMP2, MMP9, NR3C1, PIK3CA, PPARA, PTGS2, RORC, SRC, TRPV1, TYR | 7.99172 |
[BP] GO:0019748 | secondary metabolic process | AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, CYP2D6, TYR | 7.99172 |
[BP] GO:0010941 | regulation of cell death | ADORA1, AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, FLT3, GRIK5, HCAR2, HMGCR, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, SRC, TRPV1, XDH | 7.63319 |
[BP] GO:0043067 | regulation of programmed cell death | ADORA1, AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, FLT3, GRIK5, HCAR2, HMGCR, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, TRPV1, XDH | 7.53945 |
[BP] GO:0001676 | long-chain fatty acid metabolic process | ALOX12, ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, PTGS1, PTGS2 | 7.13309 |
[BP] GO:0071310 | cellular response to organic substance | AKR1B1, ALOX15, ALPL, APP, AXL, BCL2, CYP1A1, CYP1B1, ESR1, FABP4, FLT3, GRIK5, GRM5, IGF1R, KDR, MMP2, NR3C1, PIK3CA, PTGS2, RORC, SRC, TRPV1 | 7.00532 |
[BP] GO:0070887 | cellular response to chemical stimulus | AKR1B1, ALOX15, ALPL, APP, AXL, BCL2, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, GRIK5, GRM5, IGF1R, KDR, MMP2, MMP9, NR3C1, PIK3CA, PTGS2, RORC, SRC, TRPV1 | 6.97784 |
[BP] GO:0042981 | regulation of apoptotic process | ADORA1, AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, FLT3, GRIK5, HCAR2, HMGCR, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, TRPV1, XDH | 6.90048 |
[BP] GO:0010647 | positive regulation of cell communication | ADORA1, AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F10, FLT3, GRM1, HCAR2, HMGCR, KDR, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH | 6.90048 |
[BP] GO:0023056 | positive regulation of signaling | ADORA1, AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F10, FLT3, GRM1, HCAR2, HMGCR, KDR, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH | 6.89451 |
[BP] GO:1901568 | fatty acid derivative metabolic process | ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, PTGS1, PTGS2 | 6.89451 |
[BP] GO:0015701 | bicarbonate transport | CA1, CA12, CA14, CA2, CA4, CA7, CA9 | 6.89451 |
[BP] GO:0033993 | response to lipid | ALPL, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, ESR1, FABP3, FLT3, HSD17B2, NR3C1, PTGS2, RORC, SRC, TYR | 6.56685 |
[BP] GO:0014070 | response to organic cyclic compound | ALPL, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FLT3, NR3C1, PTGS2, RORC, SRC, TRPV1, TYR | 6.53325 |
[BP] GO:0006631 | fatty acid metabolic process | ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, PPARA, PTGS1, PTGS2 | 6.49528 |
[BP] GO:0010035 | response to inorganic substance | AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, MMP9, PTGS2, SRC | 6.36842 |
[BP] GO:1902533 | positive regulation of intracellular signal transduction | ADORA1, AKR1B1, ALOX15, APP, AXL, BCL2, CYP1B1, F10, FLT3, GRM1, HMGCR, KDR, MET, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH | 6.32809 |
[BP] GO:0048522 | positive regulation of cellular process | ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, F10, FABP3, FLT3, GRIK5, GRM1, GRM5, HCAR2, HMGCR, IGF1R, KDR, MET, MMP1, MMP2, MMP9, NR3C1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TRPV1, XDH | 6.32719 |
[BP] GO:0009719 | response to endogenous stimulus | AKR1B1, ALPL, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, FABP3, FLT3, GRM5, IGF1R, MMP2, NR3C1, PPARA, PTGS2, SRC, TRPV1 | 6.30797 |
[BP] GO:0042445 | hormone metabolic process | ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD11B1, HSD17B1, HSD17B2 | 6.27979 |
[BP] GO:1901615 | organic hydroxy compound metabolic process | AKR1B1, AKR1B10, ALOX12, ALOX15, APP, BCL2, CYP19A1, CYP1A1, CYP1B1, CYP3A4, FDPS, HMGCR, TYR | 5.99678 |
[BP] GO:0032501 | multicellular organismal process | ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, APP, AXL, BCL2, CYP19A1, CYP1A2, CYP1B1, ESR1, F10, FABP4, GRM1, GRM5, GRM8, HMGCR, HSD17B2, IGF1R, MET, MMP1, MMP2, MMP9, PIK3CA, PIM1, PPARA, PTGS2, RORC, SRC, TRPV1, TYR | 5.91385 |
[BP] GO:0006730 | one-carbon metabolic process | CA1, CA12, CA2, CA4, CA7, CA9 | 5.87827 |
[BP] GO:0048518 | positive regulation of biological process | ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, F10, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HCAR2, HMGCR, IGF1R, KDR, MET, MMP1, MMP2, MMP9, NR3C1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SLC1A1, SRC, TRPV1, XDH | 5.77604 |
[BP] GO:0060548 | negative regulation of cell death | ADORA1, AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, HMGCR, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, SRC | 5.77059 |
[BP] GO:0034754 | cellular hormone metabolic process | AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B1, HSD17B2 | 5.72897 |
[BP] GO:0042592 | homeostatic process | ADORA1, AKR1B1, ALOX12, APP, AXL, BCL2, CA12, CA2, CA7, ESR1, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, MET, PIK3CA, PIK3CB, SRC, TRPV1 | 5.63623 |
[BP] GO:0051716 | cellular response to stimulus | AKR1B1, ALOX15, ALPL, APP, AURKB, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, GRIK5, GRM1, GRM5, IGF1R, KDR, MMP2, MMP9, NR3C1, PIK3CA, PTGS2, PTPN1, RORC, SRC, TRPV1 | 5.60266 |
[BP] GO:0010646 | regulation of cell communication | ACHE, ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, ESR1, F10, FLT3, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH | 5.60039 |
[BP] GO:1901701 | cellular response to oxygen-containing compound | AKR1B1, APP, AXL, CYP1B1, ESR1, GRIK5, GRM5, IGF1R, MMP2, MMP9, NR3C1, PIK3CA, PTGS2, RORC, SRC, TRPV1 | 5.58084 |
[BP] GO:0006805 | xenobiotic metabolic process | CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, NQO2, PTGS1, RORC | 5.5807 |
[BP] GO:1902531 | regulation of intracellular signal transduction | ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F10, FLT3, GRM1, HMGCR, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH | 5.57893 |
[BP] GO:0043069 | negative regulation of programmed cell death | ADORA1, AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, HMGCR, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PTGS2, PTPN1, SRC | 5.57893 |
[BP] GO:0008152 | metabolic process | ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, ESR1, F10, FABP3, FABP4, FDPS, FLT3, FUT7, HMGCR, HSD11B1, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, MMP9, NQO2, NR3C1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SRC, TRPV1, TYR, XDH | 5.53561 |
[BP] GO:0009725 | response to hormone | AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, FABP3, FLT3, NR3C1, PPARA, PTGS2, SRC, TRPV1 | 5.53561 |
[BP] GO:0050804 | modulation of chemical synaptic transmission | ACHE, ADORA1, APP, CA2, CA7, GRIK5, GRM1, GRM3, GRM5, GRM8, PTGS2 | 5.53561 |
[BP] GO:0099177 | regulation of trans-synaptic signaling | ACHE, ADORA1, APP, CA2, CA7, GRIK5, GRM1, GRM3, GRM5, GRM8, PTGS2 | 5.53561 |
[BP] GO:0023051 | regulation of signaling | ACHE, ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, ESR1, F10, FLT3, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH | 5.53561 |
[BP] GO:0006720 | isoprenoid metabolic process | AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, FDPS, HMGCR | 5.33856 |
[BP] GO:0006694 | steroid biosynthetic process | AKR1B1, CYP19A1, CYP3A4, FDPS, HMGCR, HSD11B1, HSD17B1, HSD17B2 | 5.31745 |
[BP] GO:0019220 | regulation of phosphate metabolic process | ADORA1, ALOX15, APP, BCL2, CDC25B, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, XDH | 5.31103 |
[BP] GO:0007196 | None | GRM1, GRM3, GRM5, GRM8 | 5.26332 |
[BP] GO:0051174 | regulation of phosphorus metabolic process | ADORA1, ALOX15, APP, BCL2, CDC25B, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, XDH | 5.26332 |
[BP] GO:0048878 | chemical homeostasis | AKR1B1, ALOX12, APP, BCL2, CA12, CA2, CA7, ESR1, FABP3, FABP4, GRIK5, GRM1, GRM5, MET, PIK3CA, PIK3CB, TRPV1 | 5.14226 |
[BP] GO:0010817 | regulation of hormone levels | ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HCAR2, HMGCR, HSD11B1, HSD17B1, HSD17B2 | 5.14226 |
[BP] GO:0001934 | positive regulation of protein phosphorylation | ADORA1, ALOX15, APP, BCL2, CDC25B, FLT3, GRM1, GRM5, HMGCR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH | 5.13633 |
[BP] GO:0042127 | regulation of cell proliferation | ADORA1, ADORA3, AKR1B1, ALOX12, APP, BCL2, CDC25B, CSNK2A1, CYP1B1, ESR1, FABP3, FLT3, HMGCR, IGF1R, KDR, MMP2, MMP9, PIM1, PTGS1, PTGS2, SRC, XDH | 5.12042 |
[BP] GO:0032879 | regulation of localization | ACHE, ADORA1, ADORA3, ALOX12, ALOX15, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F10, GRIK5, GRM5, HCAR2, HMGCR, IGF1R, KDR, MET, MMP9, PIK3CB, PPARA, PTGS2, PTPN1, SRC, TRPV1 | 5.0945 |
[BP] GO:0050896 | response to stimulus | ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, ALPL, APP, AURKB, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, F10, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HMGCR, HSD17B2, IGF1R, KDR, MMP2, MMP9, NR3C1, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, PTPN1, RORC, SRC, TRPV1, TYR | 5.00195 |
[BP] GO:0009967 | positive regulation of signal transduction | ADORA1, AKR1B1, ALOX15, APP, AXL, BCL2, CSNK2A1, CYP1B1, F10, FLT3, GRM1, HMGCR, KDR, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH | 5.00195 |
[BP] GO:0010562 | positive regulation of phosphorus metabolic process | ADORA1, ALOX15, APP, BCL2, CDC25B, FABP3, FLT3, GRM1, GRM5, HMGCR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH | 4.99403 |
[BP] GO:0045937 | positive regulation of phosphate metabolic process | ADORA1, ALOX15, APP, BCL2, CDC25B, FABP3, FLT3, GRM1, GRM5, HMGCR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH | 4.99403 |
[BP] GO:0043066 | negative regulation of apoptotic process | ADORA1, AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, HMGCR, IGF1R, KDR, MMP9, PIK3CA, PIM1, PTGS2, PTPN1, SRC | 4.9863 |
[BP] GO:0071407 | cellular response to organic cyclic compound | ALPL, APP, CYP1A1, CYP1B1, ESR1, FLT3, NR3C1, PTGS2, RORC, SRC, TRPV1 | 4.96889 |
[BP] GO:0007166 | cell surface receptor signaling pathway | ADORA1, ADORA3, APP, AXL, BCL2, CA1, CSNK2A1, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC, TRPV1 | 4.95252 |
[BP] GO:0042327 | positive regulation of phosphorylation | ADORA1, ALOX15, APP, BCL2, CDC25B, FLT3, GRM1, GRM5, HMGCR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH | 4.92283 |
[BP] GO:0019216 | regulation of lipid metabolic process | ADORA1, CYP1A1, FABP3, FDPS, FLT3, HCAR2, HMGCR, PPARA, PTGS2, RORC, SRC | 4.83981 |
[BP] GO:0051966 | regulation of synaptic transmission, glutamatergic | ADORA1, GRM1, GRM3, GRM5, GRM8, PTGS2 | 4.82029 |
[BP] GO:0044237 | cellular metabolic process | ACHE, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, ESR1, F10, FABP3, FABP4, FDPS, FLT3, FUT7, HMGCR, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, NQO2, NR3C1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SRC, TYR, XDH | 4.78454 |
[BP] GO:0042446 | hormone biosynthetic process | AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD17B1, HSD17B2 | 4.74578 |
[BP] GO:0044092 | negative regulation of molecular function | ADORA3, APP, AURKB, CSNK2A1, CYP1B1, CYP2D6, ESR1, FABP4, GRM3, HMGCR, IGF1R, MET, MMP9, PIM1, PPARA, PTGS2, PTPN1, SRC | 4.67026 |
[BP] GO:0032844 | regulation of homeostatic process | ADORA1, AURKB, BCL2, CA2, CA7, HCAR2, HMGCR, KDR, PIK3CB, PTGS2, SRC, TRPV1 | 4.63082 |
[BP] GO:0006721 | terpenoid metabolic process | AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, FDPS | 4.62917 |
[BP] GO:1901617 | organic hydroxy compound biosynthetic process | AKR1B1, ALOX12, ALOX15, CYP19A1, CYP3A4, FDPS, HMGCR, TYR | 4.61483 |
[BP] GO:0032787 | None | ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, PPARA, PTGS1, PTGS2 | 4.6045 |
[BP] GO:0007216 | None | GRM1, GRM3, GRM5, GRM8 | 4.5169 |
[BP] GO:0032847 | regulation of cellular pH reduction | BCL2, CA2, CA7 | 4.44254 |
[BP] GO:0042325 | regulation of phosphorylation | ADORA1, ALOX15, APP, BCL2, CDC25B, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, XDH | 4.44236 |
[BP] GO:0046456 | icosanoid biosynthetic process | ALOX12, ALOX15, ALOX5, PTGS1, PTGS2 | 4.38993 |
[BP] GO:0001932 | regulation of protein phosphorylation | ADORA1, ALOX15, APP, BCL2, CDC25B, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH | 4.34483 |
[BP] GO:0015711 | organic anion transport | CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, SLC1A1, TRPV1 | 4.30118 |
[BP] GO:0019372 | lipoxygenase pathway | ALOX12, ALOX15, ALOX5, PTGS2 | 4.29179 |
[BP] GO:0060078 | None | ADORA1, GRIA2, GRIA4, GRIK5, GRM5, TRPV1 | 4.20943 |
[BP] GO:0032502 | developmental process | ACHE, ADORA1, AKR1B1, ALOX15, ALPL, APP, AURKB, AXL, BCL2, CA2, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, FUT7, HMGCR, HSD11B1, HSD17B2, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, RORC, SRC, TYR | 4.19774 |
[BP] GO:0044283 | None | AKR1B1, ALOX12, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP3A4, FDPS, HMGCR, PTGS1, PTGS2 | 4.11646 |
[BP] GO:0030334 | regulation of cell migration | ADORA1, ADORA3, ALOX12, APP, BCL2, CYP19A1, CYP1B1, F10, IGF1R, KDR, MET, MMP9, PTGS2, SRC | 4.04914 |
[BP] GO:0048513 | animal organ development | ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, FLT3, HSD11B1, HSD17B2, KDR, PIK3CA, PPARA, SRC, TYR | 3.91937 |
[BP] GO:0006796 | phosphate-containing compound metabolic process | ACHE, ALOX15, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, FDPS, FLT3, HMGCR, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, XDH | 3.91937 |
[BP] GO:0031401 | positive regulation of protein modification process | ADORA1, ALOX15, APP, BCL2, CDC25B, FLT3, GRM1, GRM5, HMGCR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH | 3.81803 |
[BP] GO:2001300 | lipoxin metabolic process | ALOX12, ALOX15, ALOX5 | 3.81803 |
[BP] GO:0016098 | monoterpenoid metabolic process | CYP1A2, CYP2D6, CYP3A4 | 3.81803 |
[BP] GO:0048584 | positive regulation of response to stimulus | ADORA1, AKR1B1, ALOX15, APP, AXL, BCL2, CSNK2A1, CYP1B1, F10, FABP4, FLT3, GRM1, HMGCR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH | 3.77245 |
[BP] GO:2000145 | regulation of cell motility | ADORA1, ADORA3, ALOX12, APP, BCL2, CYP19A1, CYP1B1, F10, IGF1R, KDR, MET, MMP9, PTGS2, SRC | 3.74341 |
[BP] GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC | 3.60958 |
[BP] GO:0006793 | phosphorus metabolic process | ACHE, ALOX15, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, FDPS, FLT3, HMGCR, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, XDH | 3.60954 |
[BP] GO:0042391 | None | ADORA1, APP, BCL2, GRIA2, GRIA4, GRIK5, GRM5, KDR, SRC, TRPV1 | 3.60458 |
[BP] GO:0008210 | estrogen metabolic process | CYP19A1, CYP1B1, HSD17B1, HSD17B2 | 3.60326 |
[BP] GO:0009820 | alkaloid metabolic process | CYP1A2, CYP2D6, CYP3A4 | 3.60326 |
[BP] GO:0019752 | carboxylic acid metabolic process | ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, PIM1, PPARA, PTGS1, PTGS2, TYR | 3.54804 |
[BP] GO:0042493 | response to drug | AKR1B1, AXL, BCL2, CA9, CYP1A1, CYP1B1, FABP3, HMGCR, KDR, NR3C1, PTGS2, SRC, TRPV1 | 3.54476 |
[BP] GO:0043410 | positive regulation of MAPK cascade | ADORA1, ALOX15, APP, FLT3, GRM1, HMGCR, KDR, PIK3CB, PTPN1, SRC, XDH | 3.5326 |
[BP] GO:0010038 | response to metal ion | ALOX15, APP, BCL2, CA2, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 | 3.50807 |
[BP] GO:0009628 | response to abiotic stimulus | ADORA1, AKR1B1, APP, AURKB, BCL2, CA2, CYP1A1, GRM1, HMGCR, MMP2, PPARA, PTGS2, SRC, TRPV1, TYR | 3.48984 |
[BP] GO:0035235 | None | APP, GRIA2, GRIA4, GRIK5 | 3.4834 |
[BP] GO:0008284 | positive regulation of cell proliferation | AKR1B1, ALOX12, BCL2, CDC25B, CSNK2A1, ESR1, FLT3, HMGCR, IGF1R, KDR, MMP2, MMP9, PIM1, PTGS2 | 3.42352 |
[BP] GO:0051247 | positive regulation of protein metabolic process | ADORA1, ALOX15, APP, BCL2, CDC25B, CSNK2A1, ESR1, FLT3, GRM1, GRM5, HMGCR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH | 3.408 |
[BP] GO:0040012 | regulation of locomotion | ADORA1, ADORA3, ALOX12, APP, BCL2, CYP19A1, CYP1B1, F10, IGF1R, KDR, MET, MMP9, PTGS2, SRC | 3.39905 |
[BP] GO:0044238 | primary metabolic process | ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, APP, AURKB, AXL, BCL2, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, ESR1, F10, FABP3, FABP4, FDPS, FLT3, FUT7, HMGCR, HSD11B1, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, MMP9, NR3C1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SRC, TRPV1, TYR, XDH | 3.39905 |
[BP] GO:0051270 | regulation of cellular component movement | ADORA1, ADORA3, ALOX12, APP, BCL2, CYP19A1, CYP1B1, F10, IGF1R, KDR, MET, MMP9, PTGS2, SRC | 3.3892 |
[BP] GO:0006636 | unsaturated fatty acid biosynthetic process | ALOX12, ALOX15, PTGS1, PTGS2 | 3.31535 |
[BP] GO:0006820 | anion transport | CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, SLC1A1, TRPV1 | 3.30894 |
[BP] GO:0006979 | response to oxidative stress | AKR1B1, APP, AXL, BCL2, CYP1B1, MMP9, PTGS1, PTGS2, SRC | 3.29584 |
[BP] GO:0030335 | positive regulation of cell migration | ALOX12, APP, BCL2, F10, IGF1R, KDR, MET, MMP9, PTGS2, SRC | 3.28819 |
[BP] GO:0045859 | regulation of protein kinase activity | ADORA1, APP, CDC25B, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, PIK3CA, PIK3CB, PTPN1, SRC | 3.26761 |
[BP] GO:0009056 | catabolic process | ACHE, ADORA1, AKR1B10, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, FABP3, FABP4, FUT7, MMP1, MMP2, MMP9, PIK3CB, SRC, XDH | 3.25529 |
[BP] GO:0048871 | multicellular organismal homeostasis | ADORA1, AKR1B1, ALOX12, MET, PIK3CA, TRPV1 | 3.25249 |
[BP] GO:1901652 | response to peptide | AKR1B1, APP, FABP3, GRM5, IGF1R, PPARA, PTGS2, SRC, TRPV1 | 3.25152 |
[BP] GO:0051173 | positive regulation of nitrogen compound metabolic process | ADORA1, ALOX15, APP, AURKB, BCL2, CDC25B, CSNK2A1, ESR1, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MET, MMP9, NR3C1, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SRC, TRPV1, XDH | 3.24411 |
[BP] GO:0060079 | None | ADORA1, GRIA2, GRIA4, GRIK5, TRPV1 | 3.19441 |
[BP] GO:0051049 | regulation of transport | ACHE, ADORA1, ALOX15, APP, AXL, BCL2, CA2, CA7, CYP19A1, GRIK5, GRM5, HCAR2, HMGCR, MMP9, PIK3CB, PPARA, PTGS2, PTPN1, SRC, TRPV1 | 3.18848 |
[BP] GO:0032270 | positive regulation of cellular protein metabolic process | ADORA1, ALOX15, APP, BCL2, CDC25B, ESR1, FLT3, GRM1, GRM5, HMGCR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH | 3.18186 |
[BP] GO:2000147 | positive regulation of cell motility | ALOX12, APP, BCL2, F10, IGF1R, KDR, MET, MMP9, PTGS2, SRC | 3.18186 |
[BP] GO:2001225 | regulation of chloride transport | CA2, CA7, GRM5 | 3.17102 |
[BP] GO:0097267 | omega-hydroxylase P450 pathway | CYP1A1, CYP1A2, CYP1B1 | 3.17102 |
[BP] GO:0016042 | lipid catabolic process | ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4 | 3.16412 |
[BP] GO:0043436 | oxoacid metabolic process | ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, PIM1, PPARA, PTGS1, PTGS2, TYR | 3.14799 |
[BP] GO:0048010 | vascular endothelial growth factor receptor signaling pathway | AXL, KDR, PIK3CA, PIK3CB, SRC | 3.12609 |
[BP] GO:0046777 | protein autophosphorylation | AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC | 3.09566 |
[BP] GO:0051272 | positive regulation of cellular component movement | ALOX12, APP, BCL2, F10, IGF1R, KDR, MET, MMP9, PTGS2, SRC | 3.09566 |
[BP] GO:0065009 | regulation of molecular function | ADORA1, ADORA3, APP, AURKB, BCL2, CDC25B, CSNK2A1, CYP1B1, CYP2D6, ESR1, FABP4, FLT3, GRM1, GRM3, GRM5, HMGCR, IGF1R, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, SRC, TRPV1, XDH | 3.0825 |
[BP] GO:0006082 | organic acid metabolic process | ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, PIM1, PPARA, PTGS1, PTGS2, TYR | 3.0825 |
[BP] GO:0019371 | None | CBR1, PTGS1, PTGS2 | 3.06657 |
[BP] GO:0035690 | cellular response to drug | AKR1B1, AXL, CYP1B1, KDR, NR3C1, PTGS2, SRC, TRPV1 | 3.05833 |
[BP] GO:0007193 | None | ADORA1, GRM1, GRM3, GRM5, GRM8 | 3.04017 |
[BP] GO:0048661 | positive regulation of smooth muscle cell proliferation | AKR1B1, HMGCR, MMP2, MMP9, PTGS2 | 3.04017 |
[BP] GO:0009987 | cellular process | ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, ESR1, F10, FABP3, FABP4, FDPS, FLT3, FUT7, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, MMP9, NQO2, NR3C1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SRC, TRPV1, TYR, XDH | 3.01864 |
[BP] GO:0043408 | regulation of MAPK cascade | ADORA1, ALOX15, APP, FLT3, GRM1, HMGCR, IGF1R, KDR, PIK3CB, PTPN1, SRC, XDH | 3.01751 |
[BP] GO:0031325 | positive regulation of cellular metabolic process | ADORA1, ALOX15, APP, AURKB, BCL2, CDC25B, ESR1, FABP3, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MET, MMP9, NR3C1, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SRC, TRPV1, XDH | 3.01062 |
[BP] GO:0043549 | regulation of kinase activity | ADORA1, APP, CDC25B, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, PIK3CA, PIK3CB, PTPN1, SRC | 3.00878 |
[BP] GO:0043393 | regulation of protein binding | APP, AURKB, BCL2, MET, MMP9, PPARA, SRC | 3.00878 |
[BP] GO:0065007 | biological regulation | ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, ALOX15, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, ESR1, F10, FABP3, FABP4, FDPS, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, MMP9, NR3C1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SRC, TRPV1, XDH | 3.00572 |
[BP] GO:0040017 | positive regulation of locomotion | ALOX12, APP, BCL2, F10, IGF1R, KDR, MET, MMP9, PTGS2, SRC | 3.00418 |
[BP] GO:2000021 | regulation of ion homeostasis | ADORA1, BCL2, CA2, CA7, KDR, SRC, TRPV1 | 2.98274 |
[BP] GO:0070989 | oxidative demethylation | CYP1A2, CYP2D6, CYP3A4 | 2.98274 |
[BP] GO:0050790 | regulation of catalytic activity | ADORA1, ADORA3, APP, AURKB, BCL2, CDC25B, CSNK2A1, ESR1, FABP4, FLT3, GRM1, GRM3, GRM5, HMGCR, IGF1R, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH | 2.98274 |
[BP] GO:0031399 | regulation of protein modification process | ADORA1, ALOX15, APP, BCL2, CDC25B, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH | 2.98274 |
[BP] GO:0043065 | positive regulation of apoptotic process | BCL2, CYP1B1, GRIK5, HCAR2, HMGCR, MMP9, PIK3CB, PTGS2, SRC, TRPV1, XDH | 2.9789 |
[BP] GO:1901570 | None | ALOX12, ALOX15, ALOX5, PTGS1, PTGS2 | 2.96939 |
[BP] GO:0051896 | regulation of protein kinase B signaling | AXL, F10, MET, PIK3CA, PIK3CB, SRC, XDH | 2.95399 |
[BP] GO:0048856 | anatomical structure development | ACHE, ADORA1, AKR1B1, ALOX15, ALPL, APP, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FLT3, HSD11B1, HSD17B2, KDR, MMP9, PIK3CA, PIM1, PPARA, PTGS2, RORC, SRC, TYR | 2.94952 |
[BP] GO:0043068 | positive regulation of programmed cell death | BCL2, CYP1B1, GRIK5, HCAR2, HMGCR, MMP9, PIK3CB, PTGS2, SRC, TRPV1, XDH | 2.94759 |
[BP] GO:0051338 | regulation of transferase activity | ADORA1, APP, AURKB, CDC25B, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, PIK3CA, PIK3CB, PTPN1, SRC | 2.89574 |
[BP] GO:0048523 | negative regulation of cellular process | ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, APP, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, ESR1, FABP3, FABP4, GRM3, GRM8, HMGCR, IGF1R, KDR, MET, MMP9, NR3C1, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TRPV1, XDH | 2.8922 |
[BP] GO:0006703 | estrogen biosynthetic process | CYP19A1, HSD17B1, HSD17B2 | 2.89093 |
[BP] GO:2001301 | lipoxin biosynthetic process | ALOX12, ALOX15 | 2.88819 |
[BP] GO:2001302 | lipoxin A4 metabolic process | ALOX12, ALOX15 | 2.88819 |
[BP] GO:2001303 | lipoxin A4 biosynthetic process | ALOX12, ALOX15 | 2.88819 |
[BP] GO:0009636 | response to toxic substance | AKR1B1, ALPL, AXL, BCL2, CYP1A1, CYP1B1, HMGCR, KDR, SRC | 2.88819 |
[BP] GO:0048545 | response to steroid hormone | ALPL, BCL2, CA2, FLT3, NR3C1, PTGS2, SRC | 2.87815 |
[BP] GO:0048519 | negative regulation of biological process | ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, ALOX15, APP, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, ESR1, FABP3, FABP4, GRM3, GRM8, HCAR2, HMGCR, IGF1R, KDR, MET, MMP9, NR3C1, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TRPV1, XDH | 2.87815 |
[BP] GO:0009893 | positive regulation of metabolic process | ADORA1, ALOX15, APP, AURKB, BCL2, CDC25B, CSNK2A1, ESR1, FABP3, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MET, MMP9, NR3C1, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SRC, TRPV1, XDH | 2.87383 |
[BP] GO:0009892 | negative regulation of metabolic process | ADORA1, APP, AURKB, BCL2, CSNK2A1, CYP2D6, ESR1, FABP4, GRM3, GRM8, HCAR2, HMGCR, IGF1R, KDR, MET, MMP9, NR3C1, PIK3CA, PPARA, PTGS2, PTPN1, RORC, SRC, TRPV1, XDH | 2.86603 |
[BP] GO:1902532 | negative regulation of intracellular signal transduction | BCL2, ESR1, HMGCR, IGF1R, MET, MMP9, PTGS2, PTPN1, SRC, XDH | 2.84829 |
[BP] GO:0010243 | response to organonitrogen compound | AKR1B1, APP, FABP3, FLT3, GRM5, IGF1R, MMP2, PPARA, PTGS2, SRC, TRPV1, TYR | 2.8422 |
[BP] GO:0071248 | cellular response to metal ion | ALOX15, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 | 2.83838 |
[BP] GO:0060065 | uterus development | CYP19A1, ESR1, SRC | 2.8198 |
[BP] GO:0071704 | organic substance metabolic process | ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, APP, AURKB, AXL, BCL2, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, ESR1, F10, FABP3, FABP4, FDPS, FLT3, FUT7, HMGCR, HSD11B1, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, MMP9, NR3C1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SRC, TRPV1, TYR, XDH | 2.7995 |
[BP] GO:0007165 | signal transduction | ADORA1, ADORA3, AKR1B1, APP, AXL, BCL2, CA1, CA2, CSNK2A1, CYP1B1, ESR1, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, MMP2, MMP9, NR3C1, PIK3CA, PIK3CB, PIM1, PPARA, PTPN1, RORC, SRC, TRPV1 | 2.78868 |
[BP] GO:0051897 | positive regulation of protein kinase B signaling | AXL, F10, MET, PIK3CA, PIK3CB, SRC | 2.78035 |
[BP] GO:0055082 | cellular chemical homeostasis | APP, BCL2, CA2, CA7, ESR1, GRIK5, GRM1, GRM5, PIK3CA, PIK3CB, TRPV1 | 2.74303 |
[BP] GO:0008283 | cell proliferation | ACHE, AURKB, BCL2, CYP1A1, ESR1, FLT3, MET, PIK3CB, PIM1, SRC, TYR | 2.73986 |
[BP] GO:0031960 | response to corticosteroid | ALPL, BCL2, FLT3, NR3C1, PTGS2, SRC | 2.73986 |
[BP] GO:0010942 | positive regulation of cell death | BCL2, CYP1B1, GRIK5, HCAR2, HMGCR, MMP9, PIK3CB, PTGS2, SRC, TRPV1, XDH | 2.70182 |
[BP] GO:0009991 | response to extracellular stimulus | ALPL, AXL, BCL2, CYP1A1, HMGCR, PTGS2, SRC, TRPV1, TYR | 2.68001 |
[BP] GO:2001243 | negative regulation of intrinsic apoptotic signaling pathway | BCL2, MMP9, PTGS2, PTPN1, SRC | 2.67381 |
[BP] GO:0006954 | inflammatory response | ADORA1, ADORA3, ALOX15, AXL, PIK3CA, PIK3CB, PTGS1, PTGS2, TRPV1 | 2.66333 |
[BP] GO:0050801 | ion homeostasis | APP, BCL2, CA12, CA2, CA7, ESR1, FABP3, GRM1, GRM5, PIK3CB, TRPV1 | 2.66333 |
[BP] GO:2000811 | negative regulation of anoikis | BCL2, PIK3CA, SRC | 2.66333 |
[BP] GO:0030540 | female genitalia development | AXL, CYP19A1, ESR1 | 2.66333 |
[BP] GO:0006468 | protein phosphorylation | APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIM1, SRC | 2.65967 |
[BP] GO:0007167 | enzyme linked receptor protein signaling pathway | AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC | 2.63916 |
[BP] GO:0043405 | regulation of MAP kinase activity | ADORA1, FLT3, GRM1, HMGCR, IGF1R, PIK3CB, PTPN1, SRC | 2.60057 |
[BP] GO:0071495 | cellular response to endogenous stimulus | AKR1B1, APP, ESR1, FLT3, GRM5, IGF1R, MMP2, NR3C1, PTGS2, SRC, TRPV1 | 2.59326 |
[BP] GO:0051098 | regulation of binding | APP, AURKB, BCL2, CYP2D6, MET, MMP9, PPARA, SRC | 2.57698 |
[BP] GO:1901698 | response to nitrogen compound | AKR1B1, APP, FABP3, FLT3, GRM5, IGF1R, MMP2, PPARA, PTGS2, SRC, TRPV1, TYR | 2.55874 |
[BP] GO:0072593 | reactive oxygen species metabolic process | ALOX12, BCL2, CYP1A1, CYP1A2, CYP1B1 | 2.54815 |
[BP] GO:0071241 | cellular response to inorganic substance | ALOX15, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 | 2.51791 |
[BP] GO:0010604 | positive regulation of macromolecule metabolic process | ADORA1, ALOX15, APP, AURKB, BCL2, CDC25B, CSNK2A1, ESR1, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MET, MMP9, NR3C1, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SRC, XDH | 2.49773 |
[BP] GO:0000302 | response to reactive oxygen species | AKR1B1, AXL, BCL2, CYP1B1, MMP9, SRC | 2.49631 |
[BP] GO:0099566 | None | GRM1, GRM5 | 2.49631 |
[BP] GO:0009822 | alkaloid catabolic process | CYP2D6, CYP3A4 | 2.49631 |
[BP] GO:0032849 | positive regulation of cellular pH reduction | CA2, CA7 | 2.49631 |
[BP] GO:0030522 | intracellular receptor signaling pathway | ESR1, NR3C1, PIM1, PPARA, RORC, SRC | 2.49475 |
[BP] GO:0001666 | response to hypoxia | ADORA1, BCL2, CYP1A1, MMP2, PPARA, PTGS2, SRC | 2.49359 |
[BP] GO:0051900 | regulation of mitochondrial depolarization | BCL2, KDR, SRC | 2.47209 |
[BP] GO:0042542 | response to hydrogen peroxide | AKR1B1, AXL, BCL2, CYP1B1, SRC | 2.46108 |
[BP] GO:0034614 | cellular response to reactive oxygen species | AKR1B1, AXL, CYP1B1, MMP9, SRC | 2.46108 |
[BP] GO:0009611 | response to wounding | ACHE, ADORA3, ALOX15, BCL2, CYP1A1, PPARA | 2.45313 |
[BP] GO:0036293 | response to decreased oxygen levels | ADORA1, BCL2, CYP1A1, MMP2, PPARA, PTGS2, SRC | 2.42787 |
[BP] GO:0016310 | phosphorylation | APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, SRC | 2.40703 |
[BP] GO:0018108 | peptidyl-tyrosine phosphorylation | AXL, FLT3, IGF1R, KDR, MET, SRC | 2.36994 |
[BP] GO:0001503 | ossification | ALOX15, ALPL, BCL2, MMP2, MMP9 | 2.3616 |
[BP] GO:0071498 | cellular response to fluid shear stress | CA2, PTGS2, SRC | 2.35781 |
[BP] GO:0019373 | epoxygenase P450 pathway | CYP1A1, CYP1A2, CYP1B1 | 2.35781 |
[BP] GO:0006066 | None | AKR1B1, AKR1B10, APP, CYP1B1, CYP3A4, FDPS, HMGCR | 2.34649 |
[BP] GO:0018212 | peptidyl-tyrosine modification | AXL, FLT3, IGF1R, KDR, MET, SRC | 2.34035 |
[BP] GO:0070988 | demethylation | CYP1A1, CYP1A2, CYP2D6, CYP3A4 | 2.34035 |
[BP] GO:0007584 | response to nutrient | ALPL, CYP1A1, HMGCR, PTGS2, TRPV1, TYR | 2.29501 |
[BP] GO:0048511 | rhythmic process | AXL, BCL2, CSNK2A1, ESR1, PPARA, RORC, SRC | 2.27779 |
[BP] GO:0050806 | positive regulation of synaptic transmission | ADORA1, APP, CA2, CA7, PTGS2 | 2.25546 |
[BP] GO:2000209 | regulation of anoikis | BCL2, PIK3CA, SRC | 2.2527 |
[BP] GO:0009404 | toxin metabolic process | CYP1A1, CYP1A2, CYP1B1 | 2.2527 |
[BP] GO:0033031 | positive regulation of neutrophil apoptotic process | HCAR2, PIK3CB | 2.25171 |
[BP] GO:0018894 | dibenzo-p-dioxin metabolic process | CYP1A1, CYP1A2 | 2.25171 |
[BP] GO:0045834 | positive regulation of lipid metabolic process | FABP3, FLT3, PPARA, PTGS2, SRC | 2.23668 |
[BP] GO:0070482 | response to oxygen levels | ADORA1, BCL2, CYP1A1, MMP2, PPARA, PTGS2, SRC | 2.2311 |
[BP] GO:0071417 | cellular response to organonitrogen compound | AKR1B1, APP, GRM5, IGF1R, MMP2, PTGS2, SRC, TRPV1 | 2.22969 |
[BP] GO:0051240 | positive regulation of multicellular organismal process | ALOX12, APP, AXL, BCL2, CA2, CYP1B1, HCAR2, HMGCR, KDR, MET, MMP9, PIM1, PTGS2, SLC1A1, SRC, TRPV1 | 2.22969 |
[BP] GO:0048583 | regulation of response to stimulus | ADORA1, AKR1B1, ALOX12, ALOX15, APP, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, ESR1, F10, FABP4, FLT3, GRM1, HMGCR, IGF1R, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, XDH | 2.22839 |
[BP] GO:0008299 | None | CYP1A1, FDPS, HMGCR | 2.21658 |
[BP] GO:1903409 | reactive oxygen species biosynthetic process | CYP1A1, CYP1A2, CYP1B1 | 2.21658 |
[BP] GO:0010634 | positive regulation of epithelial cell migration | KDR, MET, MMP9, PTGS2, SRC | 2.21369 |
[BP] GO:0045860 | positive regulation of protein kinase activity | ADORA1, CDC25B, FLT3, GRM1, GRM5, PIK3CA, PIK3CB, PTPN1, SRC | 2.2107 |
[BP] GO:0098771 | inorganic ion homeostasis | APP, BCL2, CA12, CA2, CA7, ESR1, GRM1, GRM5, PIK3CB, TRPV1 | 2.19006 |
[BP] GO:0046486 | glycerolipid metabolic process | ACHE, ALOX15, CSNK2A1, FABP3, FABP4, MET, PIK3CA, PIK3CB | 2.17447 |
[BP] GO:0016125 | None | APP, CYP19A1, CYP1B1, FDPS, HMGCR | 2.17352 |
[BP] GO:0048660 | regulation of smooth muscle cell proliferation | AKR1B1, HMGCR, MMP2, MMP9, PTGS2 | 2.17352 |
[BP] GO:0031667 | response to nutrient levels | ALPL, BCL2, CYP1A1, HMGCR, PTGS2, SRC, TRPV1, TYR | 2.17128 |
[BP] GO:0043401 | steroid hormone mediated signaling pathway | ESR1, NR3C1, PPARA, RORC, SRC | 2.14641 |
[BP] GO:0019725 | cellular homeostasis | APP, BCL2, CA2, CA7, ESR1, GRIK5, GRM1, GRM5, PIK3CA, PIK3CB, TRPV1 | 2.14641 |
[BP] GO:0017144 | drug metabolic process | ACHE, AKR1B1, AKR1B10, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4 | 2.13664 |
[BP] GO:0006706 | steroid catabolic process | CYP19A1, CYP1A2, CYP3A4 | 2.12985 |
[BP] GO:0042180 | None | AKR1B1, AKR1B10, CYP19A1, HMGCR | 2.12608 |
[BP] GO:0009966 | regulation of signal transduction | ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F10, FLT3, GRM1, HMGCR, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH | 2.12394 |
[BP] GO:0019222 | regulation of metabolic process | ACHE, ADORA1, ADORA3, ALOX15, APP, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, ESR1, FABP3, FABP4, FDPS, FLT3, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, IGF1R, KDR, MET, MMP9, NR3C1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TRPV1, XDH | 2.11049 |
[BP] GO:1904646 | cellular response to amyloid-beta | APP, GRM5, IGF1R | 2.08938 |
[BP] GO:0051122 | hepoxilin biosynthetic process | ALOX12, ALOX15 | 2.07726 |
[BP] GO:0051121 | hepoxilin metabolic process | ALOX12, ALOX15 | 2.07726 |
[BP] GO:0031324 | negative regulation of cellular metabolic process | APP, AURKB, BCL2, CSNK2A1, CYP2D6, ESR1, FABP4, GRM3, GRM8, HMGCR, IGF1R, MET, MMP9, NR3C1, PIK3CA, PPARA, PTGS2, PTPN1, RORC, SRC, TRPV1, XDH | 2.07726 |
[BP] GO:0030100 | regulation of endocytosis | ALOX15, APP, AXL, PIK3CB, PTPN1, SRC | 2.05763 |
[BP] GO:0033032 | regulation of myeloid cell apoptotic process | BCL2, HCAR2, PIK3CB | 2.05196 |
[BP] GO:0008209 | androgen metabolic process | CYP19A1, CYP3A4, ESR1 | 2.05196 |
[BP] GO:0001775 | cell activation | ALOX5, APP, AXL, BCL2, FLT3, FUT7, MMP9, PIK3CA, PIK3CB, RORC, SRC, TRPV1 | 2.0398 |
[BP] GO:0033674 | positive regulation of kinase activity | ADORA1, CDC25B, FLT3, GRM1, GRM5, PIK3CA, PIK3CB, PTPN1, SRC | 2.0398 |
[BP] GO:0051384 | response to glucocorticoid | ALPL, BCL2, FLT3, NR3C1, PTGS2 | 2.0398 |
[BP] GO:1901699 | cellular response to nitrogen compound | AKR1B1, APP, GRM5, IGF1R, MMP2, PTGS2, SRC, TRPV1 | 2.0398 |
[BP] GO:0061097 | None | ADORA1, APP, GRM5, PTPN1 | 2.03318 |
[BP] GO:0033280 | response to vitamin D | ALPL, PTGS2, TYR | 2.01699 |
[BP] GO:0001101 | response to acid chemical | AKR1B1, FABP3, HSD17B2, KDR, MMP2, PTGS2, SRC | 2.01699 |
[BP] GO:0031214 | biomineral tissue development | ALOX15, ALPL, PPARA, PTGS2 | 2.01699 |
[BP] GO:0051347 | positive regulation of transferase activity | ADORA1, AURKB, CDC25B, FLT3, GRM1, GRM5, PIK3CA, PIK3CB, PTPN1, SRC | 2.00825 |
[BP] GO:0032846 | positive regulation of homeostatic process | AURKB, CA2, CA7, HCAR2, PIK3CB, PTGS2 | 2.00272 |
[CC] GO:0016020 | membrane | ACHE, ADORA1, ADORA3, ALOX12, ALOX15, ALOX5, ALPL, APP, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, ESR1, F10, FLT3, FUT7, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, HSD17B2, IGF1R, KDR, MET, MMP2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SLC1A1, SRC, TRPV1, TYR | 5.26332 |
[CC] GO:0044425 | membrane part | ACHE, ADORA1, ADORA3, ALOX15, ALPL, APP, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, ESR1, F10, FLT3, FUT7, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, HSD17B2, IGF1R, KDR, MET, PIK3CA, PIK3CB, PTGS1, PTGS2, PTPN1, SLC1A1, SRC, TRPV1, TYR | 4.81855 |
[CC] GO:0005886 | plasma membrane | ACHE, ADORA1, ADORA3, ALOX12, ALOX15, ALPL, APP, AXL, CA12, CA14, CA2, CA4, CA9, CSNK2A1, ESR1, F10, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, MMP2, PIK3CA, PIK3CB, PIM1, PTPN1, SLC1A1, SRC, TRPV1 | 4.6021 |
[CC] GO:0098590 | plasma membrane region | ADORA1, CA2, CA4, CA9, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, MET, PTGS2, SLC1A1, SRC, TRPV1 | 4.29179 |
[CC] GO:0044432 | endoplasmic reticulum part | APP, BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, F10, FLT3, GRIA2, HMGCR, HSD11B1, HSD17B2, PTGS1, PTGS2, PTPN1 | 3.4834 |
[CC] GO:0042734 | None | GRIK5, GRM1, GRM3, GRM5, GRM8 | 3.3892 |
[CC] GO:0044456 | None | ACHE, ADORA1, APP, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, SRC, TRPV1 | 3.12609 |
[CC] GO:0097060 | None | GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, TRPV1 | 3.01453 |
[CC] GO:0044444 | cytoplasmic part | ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APP, AURKB, BCL2, CA1, CA2, CA4, CA7, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, ESR1, F10, FABP3, FABP4, FDPS, FLT3, FUT7, GRIA2, GRIA4, GRIK5, HMGCR, HSD11B1, HSD17B1, HSD17B2, KDR, MMP2, MMP9, NQO2, NR3C1, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SRC, TRPV1, TYR, XDH | 2.98581 |
[CC] GO:0044459 | plasma membrane part | ADORA1, ADORA3, ALOX15, APP, AXL, CA2, CA4, CA9, F10, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, PTGS2, SLC1A1, SRC, TRPV1 | 2.98274 |
[CC] GO:0031226 | intrinsic component of plasma membrane | ADORA1, ADORA3, APP, AXL, CA4, F10, FLT3, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, SLC1A1, TRPV1 | 2.89955 |
[CC] GO:0005789 | endoplasmic reticulum membrane | BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, GRIA2, HMGCR, HSD11B1, HSD17B2, PTGS1, PTGS2 | 2.7331 |
[CC] GO:0005783 | None | ADORA1, APP, BCL2, CA4, CYP19A1, CYP2D6, FLT3, GRIK5, HMGCR, KDR, PTGS2, PTPN1, XDH | 2.63916 |
[CC] GO:0043197 | None | ADORA1, APP, GRIA2, GRIA4, GRM3 | 2.30117 |
[CC] GO:0044309 | None | ADORA1, APP, GRIA2, GRIA4, GRM3 | 2.27106 |
[CC] GO:0014069 | None | ADORA1, GRIK5, GRM1, GRM3, GRM5, SRC | 2.25171 |
[CC] GO:0099572 | None | ADORA1, GRIK5, GRM1, GRM3, GRM5, SRC | 2.25171 |
[CC] GO:0005887 | integral component of plasma membrane | ADORA1, ADORA3, APP, AXL, FLT3, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, SLC1A1, TRPV1 | 2.12506 |
[CC] GO:0043005 | None | ADORA1, APP, CA2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, PTGS2, SRC | 2.12211 |
[MF] GO:0046914 | transition metal ion binding | ALOX12, ALOX15, ALOX5, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, ESR1, MMP1, MMP2, MMP9, NQO2, NR3C1, PIM1, PPARA, PTPN1, RORC, TYR, XDH | 13.0105 |
[MF] GO:0004089 | carbonate dehydratase activity | CA1, CA12, CA14, CA2, CA4, CA7, CA9 | 9.9739 |
[MF] GO:0016491 | oxidoreductase activity | AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, HMGCR, HSD11B1, HSD17B1, HSD17B2, NQO2, PTGS1, PTGS2, TYR, XDH | 9.87374 |
[MF] GO:0043167 | ion binding | ACHE, ALOX12, ALOX15, ALOX5, ALPL, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, ESR1, F10, FABP3, FABP4, FDPS, FLT3, HMGCR, HSD17B1, IGF1R, KDR, MET, MMP1, MMP2, MMP9, NQO2, NR3C1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SRC, TRPV1, TYR, XDH | 8.84847 |
[MF] GO:0003824 | catalytic activity | ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, F10, FDPS, FLT3, FUT7, HMGCR, HSD11B1, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SRC, TYR, XDH | 8.74924 |
[MF] GO:0008066 | None | GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 | 8.25886 |
[MF] GO:0070330 | aromatase activity | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4 | 6.90048 |
[MF] GO:0005506 | iron ion binding | ALOX12, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, XDH | 6.77219 |
[MF] GO:0016712 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4 | 6.63478 |
[MF] GO:0020037 | heme binding | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, PTGS1, PTGS2, SRC | 6.36842 |
[MF] GO:0016836 | hydro-lyase activity | CA1, CA12, CA14, CA2, CA4, CA7, CA9 | 6.30797 |
[MF] GO:0046906 | tetrapyrrole binding | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, PTGS1, PTGS2, SRC | 6.14821 |
[MF] GO:0043169 | cation binding | ACHE, ALOX12, ALOX15, ALOX5, ALPL, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, ESR1, F10, FDPS, MMP1, MMP2, MMP9, NQO2, NR3C1, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, TRPV1, TYR, XDH | 6.09193 |
[MF] GO:0046872 | metal ion binding | ALOX12, ALOX15, ALOX5, ALPL, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, ESR1, F10, FDPS, MMP1, MMP2, MMP9, NQO2, NR3C1, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, TRPV1, TYR, XDH | 5.77604 |
[MF] GO:0016705 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, PTGS1, PTGS2, TYR | 5.77059 |
[MF] GO:0016835 | carbon-oxygen lyase activity | CA1, CA12, CA14, CA2, CA4, CA7, CA9 | 5.53561 |
[MF] GO:0019825 | oxygen binding | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4 | 5.41017 |
[MF] GO:0048037 | cofactor binding | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, HMGCR, HSD17B1, NQO2, PTGS1, PTGS2, SRC, XDH | 5.36333 |
[MF] GO:0016614 | oxidoreductase activity, acting on CH-OH group of donors | AKR1B1, AKR1B10, CBR1, HMGCR, HSD11B1, HSD17B1, HSD17B2, XDH | 5.10879 |
[MF] GO:0038023 | signaling receptor activity | ADORA1, ADORA3, AXL, ESR1, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, NR3C1, PPARA, RORC, TRPV1 | 4.99403 |
[MF] GO:0004497 | monooxygenase activity | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, TYR | 4.94599 |
[MF] GO:0008270 | zinc ion binding | CA1, CA12, CA2, CA4, CA7, CA9, ESR1, MMP1, MMP2, MMP9, NQO2, NR3C1, PPARA, PTPN1, RORC | 4.53689 |
[MF] GO:0016616 | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | AKR1B1, AKR1B10, CBR1, HMGCR, HSD11B1, HSD17B1, HSD17B2 | 4.34953 |
[MF] GO:0004872 | receptor activity | ADORA1, ADORA3, AXL, ESR1, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, NR3C1, PPARA, RORC, TRPV1 | 4.25469 |
[MF] GO:0008144 | drug binding | ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, FLT3, IGF1R, KDR, MET, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, SRC, TRPV1 | 4.18704 |
[MF] GO:0060089 | molecular transducer activity | ADORA1, ADORA3, AXL, ESR1, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, NR3C1, PPARA, RORC, TRPV1 | 4.05324 |
[MF] GO:0004871 | signal transducer activity | ADORA1, ADORA3, AXL, ESR1, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, NR3C1, PPARA, RORC, TRPV1 | 3.63034 |
[MF] GO:0016702 | oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen | ALOX12, ALOX15, ALOX5, PTGS2 | 3.4834 |
[MF] GO:0016701 | oxidoreductase activity, acting on single donors with incorporation of molecular oxygen | ALOX12, ALOX15, ALOX5, PTGS2 | 3.42352 |
[MF] GO:0004714 | transmembrane receptor protein tyrosine kinase activity | AXL, FLT3, IGF1R, KDR, MET | 3.3892 |
[MF] GO:0016725 | oxidoreductase activity, acting on CH or CH2 groups | CYP1A2, CYP3A4, XDH | 3.28819 |
[MF] GO:0016829 | lyase activity | CA1, CA12, CA14, CA2, CA4, CA7, CA9 | 3.24411 |
[MF] GO:0008289 | lipid binding | ALOX15, AXL, CYP3A4, ESR1, F10, FABP3, FABP4, HSD17B1, NR3C1, PPARA, RORC, TRPV1 | 3.22221 |
[MF] GO:0008395 | steroid hydroxylase activity | CYP19A1, CYP1A1, CYP2D6, CYP3A4 | 3.09545 |
[MF] GO:0099600 | transmembrane receptor activity | ADORA1, ADORA3, AXL, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, TRPV1 | 3.08543 |
[MF] GO:0004888 | transmembrane signaling receptor activity | ADORA1, ADORA3, AXL, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, TRPV1 | 3.08543 |
[MF] GO:0043560 | insulin receptor substrate binding | IGF1R, PIK3CA, PIK3CB | 3.06657 |
[MF] GO:0019199 | transmembrane receptor protein kinase activity | AXL, FLT3, IGF1R, KDR, MET | 2.98274 |
[MF] GO:0004666 | prostaglandin-endoperoxide synthase activity | PTGS1, PTGS2 | 2.88819 |
[MF] GO:0047977 | hepoxilin-epoxide hydrolase activity | ALOX12, ALOX15 | 2.88819 |
[MF] GO:0042562 | hormone binding | ACHE, HSD17B1, IGF1R, NQO2, NR3C1 | 2.87401 |
[MF] GO:0005496 | steroid binding | CYP3A4, ESR1, HSD17B1, NR3C1, RORC | 2.85521 |
[MF] GO:0051213 | dioxygenase activity | ALOX12, ALOX15, ALOX5, PTGS1, PTGS2 | 2.77461 |
[MF] GO:0005231 | None | GRIA2, GRIA4, GRIK5, TRPV1 | 2.63296 |
[MF] GO:0050473 | arachidonate 15-lipoxygenase activity | ALOX15, PTGS2 | 2.49631 |
[MF] GO:0070576 | vitamin D 24-hydroxylase activity | CYP1A1, CYP3A4 | 2.49631 |
[MF] GO:0004052 | arachidonate 12-lipoxygenase activity | ALOX12, ALOX15 | 2.49631 |
[MF] GO:0051120 | hepoxilin A3 synthase activity | ALOX12, ALOX15 | 2.49631 |
[MF] GO:0099583 | None | GRM1, GRM5 | 2.49631 |
[MF] GO:0004970 | None | GRIA2, GRIA4, GRIK5 | 2.47209 |
[MF] GO:0005234 | None | GRIA2, GRIA4, GRIK5 | 2.47209 |
[MF] GO:0009055 | electron transfer activity | AKR1B1, CYP19A1, CYP1A2, NQO2, XDH | 2.46108 |
[MF] GO:0030594 | None | GRIA2, GRIA4, GRIK5, GRM1, GRM5 | 2.44546 |
[MF] GO:0042802 | identical protein binding | ACHE, APP, BCL2, CSNK2A1, ESR1, FLT3, GRIK5, HMGCR, IGF1R, KDR, MET, MMP9, NQO2, PTGS2, TRPV1, TYR, XDH | 2.44546 |
[MF] GO:0004713 | protein tyrosine kinase activity | AXL, FLT3, IGF1R, KDR, MET, SRC | 2.43106 |
[MF] GO:0003707 | steroid hormone receptor activity | ESR1, NR3C1, PPARA, RORC | 2.34035 |
[MF] GO:0034875 | caffeine oxidase activity | CYP1A2, CYP3A4 | 2.25171 |
[MF] GO:0004971 | None | GRIA2, GRIA4 | 2.25171 |
[MF] GO:0033695 | oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor | CYP1A2, CYP3A4 | 2.25171 |
[MF] GO:0099094 | None | GRIA2, GRIA4, GRIK5, TRPV1 | 2.2107 |
[MF] GO:0016773 | phosphotransferase activity, alcohol group as acceptor | AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, SRC | 2.15339 |
[MF] GO:0004672 | protein kinase activity | AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIM1, SRC | 2.14062 |
[MF] GO:0033764 | steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | HSD11B1, HSD17B1, HSD17B2 | 2.08938 |
[MF] GO:0101020 | estrogen 16-alpha-hydroxylase activity | CYP1A1, CYP3A4 | 2.07726 |
[MF] GO:0051721 | None | BCL2, HMGCR, PTPN1 | 2.05196 |
[MF] GO:0016229 | steroid dehydrogenase activity | HSD11B1, HSD17B1, HSD17B2 | 2.01699 |
[MF] GO:0005230 | None | GRIA2, GRIA4, GRIK5, TRPV1 | 2.01699 |
KEGG Pathway ID | Enriched Genes | Log10 Adjusted P-value |
---|---|---|
Ovarian steroidogenesis_Homo sapiens_hsa04913 | ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R | 9.2991 |
Nitrogen metabolism_Homo sapiens_hsa00910 | CA12, CA1, CA2, CA4, CA7, CA9, CA14 | 10.8928 |
Steroid hormone biosynthesis_Homo sapiens_hsa00140 | HSD11B1, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1 | 8.9318 |
Metabolic pathways_Homo sapiens_hsa01100 | FDPS, CBR1, ALOX15, AKR1B1, ALOX12, HMGCR, PTGS2, TYR, CYP3A4, CYP19A1, PTGS1, HSD11B1, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, ALPL, XDH | 7.6533 |
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | GRM3, GRIA2, GRM5, ADORA3, GRIK5, GRM8, ADORA1, TRPV1, NR3C1, GRM1, GRIA4 | 7.0756 |
Glutamatergic synapse_Homo sapiens_hsa04724 | GRM3, GRIA2, GRM5, GRIK5, GRM8, SLC1A1, GRM1, GRIA4 | 6.8811 |
Proteoglycans in cancer_Homo sapiens_hsa05205 | PIK3CA, SRC, MMP2, KDR, PIK3CB, MMP9, MET, ESR1, IGF1R | 6.2469 |
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | HSD11B1, CBR1, CYP2D6, CYP1A2, CYP1A1, CYP1B1, CYP3A4 | 6.8811 |
Estrogen signaling pathway_Homo sapiens_hsa04915 | PIK3CA, SRC, MMP2, PIK3CB, MMP9, ESR1, GRM1 | 6.1471 |
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | FABP4, PIK3CA, ADORA1, PIK3CB, PTGS2, PTGS1 | 6.2157 |
Chemical carcinogenesis_Homo sapiens_hsa05204 | HSD11B1, CBR1, CYP1A2, CYP1A1, CYP1B1, PTGS2, CYP3A4 | 6.5815 |
Arachidonic acid metabolism_Homo sapiens_hsa00590 | CBR1, ALOX5, ALOX15, ALOX12, PTGS2, PTGS1 | 6.0246 |
Serotonergic synapse_Homo sapiens_hsa04726 | APP, CYP2D6, ALOX5, ALOX15, ALOX12, PTGS2, PTGS1 | 5.8486 |
Pathways in cancer_Homo sapiens_hsa05200 | PIK3CA, FLT3, MMP1, MMP2, BCL2, PIK3CB, PTGS2, MMP9, MET, IGF1R | 4.9378 |
VEGF signaling pathway_Homo sapiens_hsa04370 | PIK3CA, SRC, KDR, PIK3CB, PTGS2 | 4.6402 |
cAMP signaling pathway_Homo sapiens_hsa04024 | HCAR2, GRIA2, PIK3CA, ADORA1, PIK3CB, PPARA, GRIA4 | 4.277 |
Focal adhesion_Homo sapiens_hsa04510 | PIK3CA, SRC, KDR, BCL2, PIK3CB, MET, IGF1R | 4.2659 |
MicroRNAs in cancer_Homo sapiens_hsa05206 | PIK3CA, BCL2, PIM1, CYP1B1, PTGS2, MMP9, MET, CDC25B | 4.1633 |
Phospholipase D signaling pathway_Homo sapiens_hsa04072 | GRM3, GRM5, PIK3CA, GRM8, PIK3CB, GRM1 | 4.0843 |
Adherens junction_Homo sapiens_hsa04520 | PTPN1, CSNK2A1, SRC, MET, IGF1R | 4.277 |
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | PIK3CA, MMP2, BCL2, PIM1, PIK3CB | 3.7662 |
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | PIK3CA, SRC, ALOX12, PIK3CB, TRPV1 | 3.7918 |
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | GRIA2, GRM5, PTGS2, GRM1, GRIA4 | 3.7662 |
Rap1 signaling pathway_Homo sapiens_hsa04015 | PIK3CA, SRC, KDR, PIK3CB, MET, IGF1R | 3.2987 |
Sphingolipid signaling pathway_Homo sapiens_hsa04071 | PIK3CA, ADORA3, BCL2, ADORA1, PIK3CB | 3.4417 |
Acute myeloid leukemia_Homo sapiens_hsa05221 | PIK3CA, FLT3, PIM1, PIK3CB | 3.5468 |
Bladder cancer_Homo sapiens_hsa05219 | SRC, MMP1, MMP2, MMP9 | 4.0442 |
Hepatitis B_Homo sapiens_hsa05161 | PIK3CA, SRC, BCL2, PIK3CB, MMP9 | 3.1589 |
Central carbon metabolism in cancer_Homo sapiens_hsa05230 | PIK3CA, FLT3, PIK3CB, MET | 3.3036 |
Melanoma_Homo sapiens_hsa05218 | PIK3CA, PIK3CB, MET, IGF1R | 3.2508 |
Prolactin signaling pathway_Homo sapiens_hsa04917 | PIK3CA, SRC, PIK3CB, ESR1 | 3.2414 |
Prostate cancer_Homo sapiens_hsa05215 | PIK3CA, BCL2, PIK3CB, IGF1R | 2.9622 |
PPAR signaling pathway_Homo sapiens_hsa03320 | FABP3, FABP4, MMP1, PPARA | 3.2846 |
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | PIK3CA, PIK3CB, CDC25B, IGF1R | 2.8248 |
Small cell lung cancer_Homo sapiens_hsa05222 | PIK3CA, BCL2, PIK3CB, PTGS2 | 3.0073 |
Cholinergic synapse_Homo sapiens_hsa04725 | ACHE, PIK3CA, BCL2, PIK3CB | 2.6623 |
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | PIK3CA, SRC, PIK3CB, MET | 3.1589 |
HIF-1 signaling pathway_Homo sapiens_hsa04066 | PIK3CA, BCL2, PIK3CB, IGF1R | 2.7537 |
TNF signaling pathway_Homo sapiens_hsa04668 | PIK3CA, PIK3CB, PTGS2, MMP9 | 2.667 |
Insulin resistance_Homo sapiens_hsa04931 | PTPN1, PIK3CA, PIK3CB, PPARA | 2.6714 |
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 | PIK3CA, KDR, BCL2, PIK3CB, MET, IGF1R | 2.4471 |
Ras signaling pathway_Homo sapiens_hsa04014 | PIK3CA, KDR, PIK3CB, MET, IGF1R | 2.4471 |
Platelet activation_Homo sapiens_hsa04611 | PIK3CA, SRC, PIK3CB, PTGS1 | 2.547 |
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | PIK3CA, SRC, PIK3CB, ESR1 | 2.5918 |
Toxoplasmosis_Homo sapiens_hsa05145 | PIK3CA, ALOX5, BCL2, PIK3CB | 2.5918 |
Leukocyte transendothelial migration_Homo sapiens_hsa04670 | PIK3CA, MMP2, PIK3CB, MMP9 | 2.5918 |
AMPK signaling pathway_Homo sapiens_hsa04152 | PIK3CA, PIK3CB, HMGCR, IGF1R | 2.5297 |
FoxO signaling pathway_Homo sapiens_hsa04068 | PIK3CA, PIK3CB, GRM1, IGF1R | 2.4471 |
Jak-STAT signaling pathway_Homo sapiens_hsa04630 | PIK3CA, BCL2, PIM1, PIK3CB | 2.2534 |
Oxytocin signaling pathway_Homo sapiens_hsa04921 | PIK3CA, SRC, PIK3CB, PTGS2 | 2.2534 |
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | PIK3CA, ADORA3, ADORA1, PIK3CB | 2.1801 |
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | FLT3, MMP9, MET, IGF1R | 2.0874 |
Epstein-Barr virus infection_Homo sapiens_hsa05169 | CSNK2A1, PIK3CA, BCL2, PIK3CB | 1.937 |
Glioma_Homo sapiens_hsa05214 | PIK3CA, PIK3CB, IGF1R | 2.3786 |
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | PIK3CA, PIK3CB, IGF1R | 2.3823 |
Long-term depression_Homo sapiens_hsa04730 | GRIA2, GRM1, IGF1R | 2.4471 |
ErbB signaling pathway_Homo sapiens_hsa04012 | PIK3CA, SRC, PIK3CB | 2.0884 |
Endocytosis_Homo sapiens_hsa04144 | SRC, KDR, MET, IGF1R | 1.634 |
Colorectal cancer_Homo sapiens_hsa05210 | PIK3CA, BCL2, PIK3CB | 2.414 |
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | PIK3CA, PIK3CB, IGF1R | 2.0194 |
Neurotrophin signaling pathway_Homo sapiens_hsa04722 | PIK3CA, BCL2, PIK3CB | 1.7615 |
Long-term potentiation_Homo sapiens_hsa04720 | GRIA2, GRM5, GRM1 | 2.3747 |
Measles_Homo sapiens_hsa05162 | CSNK2A1, PIK3CA, PIK3CB | 1.6417 |
Hepatitis C_Homo sapiens_hsa05160 | PIK3CA, PIK3CB, PPARA | 1.66 |
Renal cell carcinoma_Homo sapiens_hsa05211 | PIK3CA, PIK3CB, MET | 2.3747 |
NF-kappa B signaling pathway_Homo sapiens_hsa04064 | CSNK2A1, BCL2, PTGS2 | 2.0262 |
Apoptosis_Homo sapiens_hsa04210 | PIK3CA, BCL2, PIK3CB | 1.634 |
Gap junction_Homo sapiens_hsa04540 | GRM5, SRC, GRM1 | 2.0874 |
MAPK signaling pathway_Homo sapiens_hsa04010 | CDC25B | 0.2305 |
Tryptophan metabolism_Homo sapiens_hsa00380 | CYP1A2, CYP1A1, CYP1B1 | 2.8289 |
Retinol metabolism_Homo sapiens_hsa00830 | CYP1A2, CYP1A1, CYP3A4 | 2.3786 |
Insulin signaling pathway_Homo sapiens_hsa04910 | PTPN1, PIK3CA, PIK3CB | 1.634 |
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | CYP2D6, CYP1A2, CYP3A4 | 2.3265 |
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | PIK3CA, PIK3CB, IGF1R | 1.6225 |
Bile secretion_Homo sapiens_hsa04976 | CA2, HMGCR, CYP3A4 | 2.2982 |
Huntington's disease_Homo sapiens_hsa05016 | GRM5 | 0.3085 |
Herpes simplex infection_Homo sapiens_hsa05168 | CSNK2A1 | 0.3188 |
Purine metabolism_Homo sapiens_hsa00230 | XDH | 0.3317 |
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | PIK3CA, PIK3CB, PPARA | 1.5709 |
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | BCL2 | 0.3418 |
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | PIK3CA, BCL2, PIK3CB | 1.5892 |
Alzheimer's disease_Homo sapiens_hsa05010 | APP | 0.3418 |
Wnt signaling pathway_Homo sapiens_hsa04310 | CSNK2A1 | 0.3935 |
Influenza A_Homo sapiens_hsa05164 | FDPS, PIK3CA, PIK3CB | 1.431 |
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | PIK3CA, SRC, PIK3CB | 1.2423 |
Viral carcinogenesis_Homo sapiens_hsa05203 | PIK3CA, SRC, PIK3CB | 1.285 |
Cell cycle_Homo sapiens_hsa04110 | CDC25B | 0.4343 |
Axon guidance_Homo sapiens_hsa04360 | MET | 0.4288 |
Oocyte meiosis_Homo sapiens_hsa04114 | IGF1R | 0.4343 |
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | FLT3, KDR, MET | 1.0627 |
Calcium signaling pathway_Homo sapiens_hsa04020 | GRM5, GRM1 | 0.7983 |
Chemokine signaling pathway_Homo sapiens_hsa04062 | PIK3CA, SRC, PIK3CB | 1.3823 |
HTLV-I infection_Homo sapiens_hsa05166 | FDPS, PIK3CA, PIK3CB | 1.0868 |
Tuberculosis_Homo sapiens_hsa05152 | SRC, BCL2 | 0.803 |
Melanogenesis_Homo sapiens_hsa04916 | TYR | 0.5022 |
Glucagon signaling pathway_Homo sapiens_hsa04922 | PPARA | 0.5016 |
Glycerophospholipid metabolism_Homo sapiens_hsa00564 | ACHE | 0.5151 |
Tight junction_Homo sapiens_hsa04530 | CSNK2A1, SRC | 0.961 |
Pancreatic secretion_Homo sapiens_hsa04972 | CA2 | 0.5143 |
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | PIK3CA, PIK3CB | 0.9792 |
Morphine addiction_Homo sapiens_hsa05032 | ADORA1 | 0.528 |
Rheumatoid arthritis_Homo sapiens_hsa05323 | MMP1 | 0.5291 |
Osteoclast differentiation_Homo sapiens_hsa04380 | PIK3CA, PIK3CB | 0.9923 |
Hematopoietic cell lineage_Homo sapiens_hsa04640 | FLT3 | 0.5291 |
GABAergic synapse_Homo sapiens_hsa04727 | SRC | 0.5291 |
Taste transduction_Homo sapiens_hsa04742 | GRM1 | 0.5439 |
Dopaminergic synapse_Homo sapiens_hsa04728 | GRIA2, GRIA4 | 1.0058 |
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | CSNK2A1 | 0.5291 |
Protein digestion and absorption_Homo sapiens_hsa04974 | SLC1A1 | 0.5291 |
Linoleic acid metabolism_Homo sapiens_hsa00591 | ALOX15, CYP1A2, CYP3A4 | 3.1879 |
Peroxisome_Homo sapiens_hsa04146 | XDH | 0.5439 |
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | PIK3CA, PIK3CB | 1.1442 |
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | PIK3CA, PIK3CB | 1.1552 |
Amoebiasis_Homo sapiens_hsa05146 | PIK3CA, PIK3CB | 1.1702 |
Choline metabolism in cancer_Homo sapiens_hsa05231 | PIK3CA, PIK3CB | 1.1702 |
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | PIK3CA, PIK3CB | 1.2148 |
T cell receptor signaling pathway_Homo sapiens_hsa04660 | PIK3CA, PIK3CB | 1.1552 |
GnRH signaling pathway_Homo sapiens_hsa04912 | SRC, MMP2 | 1.2278 |
Complement and coagulation cascades_Homo sapiens_hsa04610 | F10 | 0.5563 |
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | PIK3CA, PIK3CB | 1.1818 |
Circadian entrainment_Homo sapiens_hsa04713 | GRIA2, GRIA4 | 1.2022 |
Leishmaniasis_Homo sapiens_hsa05140 | PTGS2 | 0.58 |
Gastric acid secretion_Homo sapiens_hsa04971 | CA2 | 0.5781 |
Adipocytokine signaling pathway_Homo sapiens_hsa04920 | PPARA | 0.5928 |
Renin secretion_Homo sapiens_hsa04924 | ADORA1 | 0.6182 |
Shigellosis_Homo sapiens_hsa05131 | SRC | 0.6182 |
Chronic myeloid leukemia_Homo sapiens_hsa05220 | PIK3CA, PIK3CB | 1.3866 |
B cell receptor signaling pathway_Homo sapiens_hsa04662 | PIK3CA, PIK3CB | 1.3866 |
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | RORC | 0.6182 |
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | PIK3CA, PIK3CB | 1.431 |
Inositol phosphate metabolism_Homo sapiens_hsa00562 | PIK3CA, PIK3CB | 1.4004 |
Pancreatic cancer_Homo sapiens_hsa05212 | PIK3CA, PIK3CB | 1.4372 |
Amphetamine addiction_Homo sapiens_hsa05031 | GRIA2, GRIA4 | 1.431 |
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | SRC, MET | 1.431 |
mTOR signaling pathway_Homo sapiens_hsa04150 | PIK3CA, PIK3CB | 1.5103 |
Glycerolipid metabolism_Homo sapiens_hsa00561 | AKR1B10, AKR1B1 | 1.5194 |
Non-small cell lung cancer_Homo sapiens_hsa05223 | PIK3CA, PIK3CB | 1.5577 |
Malaria_Homo sapiens_hsa05144 | MET | 0.7196 |
Endometrial cancer_Homo sapiens_hsa05213 | PIK3CA, PIK3CB | 1.6043 |
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | ESR1 | 0.7328 |
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | PIK3CA, PIK3CB | 1.6674 |
Type II diabetes mellitus_Homo sapiens_hsa04930 | PIK3CA, PIK3CB | 1.6353 |
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | GRIA2, BCL2 | 1.6156 |
Cocaine addiction_Homo sapiens_hsa05030 | GRM3, GRIA2 | 1.634 |
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | PIK3CA, PIK3CB | 1.7703 |
Drug metabolism - other enzymes_Homo sapiens_hsa00983 | CYP3A4, XDH | 1.66 |
Nicotine addiction_Homo sapiens_hsa05033 | GRIA2, GRIA4 | 1.7605 |
Galactose metabolism_Homo sapiens_hsa00052 | AKR1B10, AKR1B1 | 1.969 |
Tyrosine metabolism_Homo sapiens_hsa00350 | TYR | 0.8419 |
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | FUT7 | 0.8884 |
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | AKR1B10, AKR1B1 | 1.8321 |
Fructose and mannose metabolism_Homo sapiens_hsa00051 | AKR1B10, AKR1B1 | 1.9263 |
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | FUT7 | 0.9504 |
Circadian rhythm_Homo sapiens_hsa04710 | RORC | 0.8983 |
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | CA2, CA4 | 2.1594 |
Collecting duct acid secretion_Homo sapiens_hsa04966 | CA2 | 0.9385 |
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | FDPS, HMGCR | 2.1844 |
Folate biosynthesis_Homo sapiens_hsa00790 | ALPL | 1.1702 |
Caffeine metabolism_Homo sapiens_hsa00232 | CYP1A2, XDH | 3.2373 |