TCM Prescription: Fengliaoxing Fengshi Dieda Wine



Prescription Description
Prescription IDTCMF2630
Pinyin NameFeng Liao Xing Feng Shi Die Da Yao Jiu
Chinese Name冯了性风湿跌打药酒
English NameFengliaoxing Fengshi Dieda Wine
Function Description风寒湿痹, 手足麻木, 腰腿酸痛; 跌扑损伤, 瘀滞肿痛
IndicationsNumbness disorder, Rheumatoid arthritis
Disease ICD-11 Category SC62 [Numbness disorder (TM1), 麻木 (TM1) ];
FA20 [Rheumatoid arthritis, 类风湿性关节炎 ];
Human Tissues Associated with IndicationBlood, SkeletaMuscle
ReferenceChinese Classical Prescriptions
Reference Book/linkISBN 7-5023-3930-2
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH482 Erycibe obtusifolia 丁公藤 TCMH482 MG730256
TCMH761 Cinnamomum cassia 桂枝 TCMH761 GQ255631
TCMH1398 Ephedra sinica 麻黄 TCMH1398 ITSAM882-14
TCMH1665 Notopterygium incisum 羌活 TCMH1665 JF755946
TCMH421 Angelica sinensis 当归 TCMH421 ITSAF173-14
TCMH305 Cnidium officinale 川芎 TCMH305 ITSAP4207-14
TCMH118 Angelica dahurica 白芷 TCMH118 ITSAK3312-14
TCMH193 Psoralea corylifolia 补骨脂 TCMH193
TCMH1753 Boswellia carterii 乳香 TCMH1753
TCMH2569 Gleditsia sinensis 皂荚 TCMH2569 GBVO180-11, GBVO179-11
TCMH1184 Citrus reticulata 橘皮 TCMH1184 ITSAA1245-14
TCMH211 Atractylodes lancea 苍术 TCMH211 ITSAN4439-14
TCMH890 Cortex magnoliae officinalis 厚朴 TCMH890 ITSAM1591-14
TCMH2265 Cyperus rotundus 香附 TCMH2265 GENG1049-15
TCMH1533 Saussurea lappa 木香 TCMH1533
TCMH2618 Citrus aurantium 枳壳 TCMH2618 ITSAA1279-14
Reference: Chinese Classical Prescriptions

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT114 CNR2 Cannabinoid CB2 receptor GPCR P34972
TCMT115 CNR1 Cannabinoid CB1 receptor GPCR P21554
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT17 POLB DNA polymerase beta Transferase P06746
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT187 AR Androgen Receptor Nuclear receptor P10275
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT221 ABCB11 Bile salt export pump Transporter O95342
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT226 PDPK1 3-phosphoinositide dependent protein kinase-1 Kinase O15530
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT289 TBXAS1 Thromboxane-A synthase Isomerase P24557
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT327 TRPV1 Vanilloid receptor Ion channel Q8NER1
TCMT332 AOC3 Amine oxidase, copper containing Oxidoreductase Q16853
TCMT337 XPO1 Exportin-1 Unclassified O14980
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT561 NT5E 5'-nucleotidase Hydrolase P21589
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT61 MCL1 Induced myeloid leukemia cell differentiation protein Mcl-1 Unclassified Q07820
TCMT613 NR3C1 Glucocorticoid receptor Nuclear receptor P04150
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT619 HSP90AA1 Heat shock protein HSP 90-alpha Unclassified P07900
TCMT624 HSP90AB1 Heat shock protein HSP 90-beta Unclassified P08238
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT636 POLA1 DNA polymerase alpha subunit Transferase P09884
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT67 PPARG Peroxisome proliferator-activated receptor gamma Nuclear receptor P37231
TCMT683 MIF Macrophage migration inhibitory factor Isomerase P14174
TCMT689 TGM2 Protein-glutamine gamma-glutamyltransferase Transferase P21980
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT783 NR3C2 Mineralocorticoid receptor Nuclear receptor P08235
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT904 PGR Progesterone receptor Nuclear receptor P06401


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1183 Candida albicans SC5314
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1201 Staphylococcus epidermidis ATCC 12228
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1318 Human T-lymphotropic virus 1
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 11.5525
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APP, AR, AXL, BCL2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, FABP3, HSD17B2, HSP90AB1, IGF1R, MMP2, MMP9, NR3C1, POLB, PPARA, PPARG, SRC, TRPV1, TYR 11.2809
[BP] GO:0010033 response to organic substance AKR1B1, ALPL, APP, AR, AXL, BCL2, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, FABP3, FABP4, FLT3, HSD17B2, HSP90AA1, HSP90AB1, IGF1R, KDR, MCL1, MMP2, NR3C1, POLB, PPARA, PPARG, SRC, TRPV1, TYR 11.0162
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.9347
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APP, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, FABP3, FABP4, FUT7, HSD11B1, HSD17B1, HSD17B2, MET, MIF, PPARA, PPARG, TBXAS1, TRPV1 10.3438
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 9.56844
[BP] GO:0042221 response to chemical AKR1B1, ALPL, APP, AR, AXL, BCL2, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, FABP3, FABP4, FLT3, HSD17B2, HSP90AA1, HSP90AB1, IGF1R, KDR, MCL1, MMP2, MMP9, NR3C1, POLB, PPARA, PPARG, SRC, TRPV1, TYR 9.39876
[BP] GO:0014070 response to organic cyclic compound ALPL, APP, AR, BCL2, CA2, CA9, CNR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, FLT3, HSP90AB1, NR3C1, PPARG, SRC, TRPV1, TYR 9.09817
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, APP, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, FUT7, MIF, PIM1, PPARA, PPARG, TBXAS1, TYR, XDH 8.70947
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, APP, AR, AURKB, AXL, BCL2, CA12, CA2, CA7, CNR1, CNR2, CYP19A1, CYP1A1, CYP1B1, DRD1, ESR1, FABP3, FABP4, FLT3, HCAR2, HSD11B1, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, KDR, MCL1, MET, MIF, POLA1, POLB, PPARA, PPARG, SRC, TRPV1, XDH 8.70947
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, APP, AR, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD1, ESR1, ESR2, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, POLA1, POLB, PPARA, PPARG, PTPN1, SRC, TBXAS1, TRPV1, TYR, XDH 8.25975
[BP] GO:0033993 response to lipid ALPL, AR, AXL, BCL2, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, ESR1, FABP3, FLT3, HSD17B2, NR3C1, PPARG, SRC, TYR 8.25975
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, ESR1, FLT3, HCAR2, HSP90AB1, IGF1R, KDR, MCL1, MET, MIF, MMP9, PIM1, PPARA, PPARG, PTPN1, SRC, TRPV1, XDH 7.5918
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, ESR1, FLT3, HCAR2, HSP90AB1, IGF1R, KDR, MCL1, MET, MIF, MMP9, PIM1, PPARG, PTPN1, SRC, TRPV1, XDH 7.49994
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, ESR1, HSD11B1, HSD17B1, HSD17B2 7.24642
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APP, AR, BCL2, CA2, CA9, CSNK2A1, CYP1A2, DRD1, ESR1, FABP3, FLT3, IGF1R, MMP2, NR3C1, PPARA, PPARG, SRC, TRPV1 6.98884
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, APP, AXL, BCL2, CA12, CA2, CA7, CNR1, DRD1, ESR1, FABP3, FABP4, FLT3, HSP90AA1, HSP90AB1, MCL1, MET, POLA1, POLB, PPARG, SRC, TRPV1 6.95401
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, ESR1, FLT3, HCAR2, HSP90AB1, IGF1R, KDR, MCL1, MIF, MMP9, PIM1, PPARG, PTPN1, SRC, TRPV1, XDH 6.90598
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA, PPARG, TRPV1 6.82052
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APP, AR, CYP1A1, CYP1B1, DRD1, ESR1, FLT3, HSP90AB1, NR3C1, PPARG, SRC, TRPV1 6.68835
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, APP, AR, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD1, ESR1, ESR2, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, MIF, MMP1, MMP2, NR3C1, NR3C2, PGR, PIM1, POLA1, POLB, PPARA, PPARG, PTPN1, SRC, TBXAS1, TYR, XDH 6.44883
[BP] GO:0042493 response to drug AKR1B1, AXL, BCL2, CA9, CNR1, CNR2, CYP1A1, CYP1B1, DRD1, FABP3, HSP90AB1, KDR, NR3C1, POLB, PPARG, SRC, TRPV1 6.42268
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, ALPL, APP, AR, AURKB, AXL, BCL2, CA2, CA6, CA9, CHRM2, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, FABP3, FABP4, FLT3, HSD17B2, HSP90AA1, HSP90AB1, IGF1R, KDR, MCL1, MIF, MMP12, MMP2, MMP9, NR3C1, POLA1, POLB, PPARA, PPARG, PTPN1, SRC, TRPV1, TYR 6.42268
[BP] GO:0043401 steroid hormone mediated signaling pathway AR, ESR1, ESR2, NR3C1, NR3C2, PGR, PPARA, PPARG, SRC 6.2826
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, ESR1, ESR2, FABP3, FLT3, HCAR2, HSP90AA1, HSP90AB1, IGF1R, KDR, MCL1, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR3C1, PGR, PIM1, PPARA, PPARG, PTPN1, SRC, TRPV1, XDH 6.2826
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, APP, AR, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, FLT3, HCAR2, HSP90AB1, KDR, MCL1, MET, MIF, MMP12, MMP9, PTPN1, SRC, XDH 6.2433
[BP] GO:0009725 response to hormone AKR1B1, ALPL, AR, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, FABP3, FLT3, NR3C1, PPARA, PPARG, SRC, TRPV1 6.2433
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, APP, AR, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, FLT3, HCAR2, HSP90AB1, KDR, MCL1, MET, MIF, MMP12, MMP9, PTPN1, SRC, XDH 6.21835
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALPL, APP, AR, AURKB, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, FABP4, FLT3, HSP90AB1, IGF1R, KDR, MCL1, MIF, MMP2, MMP9, NR3C1, POLA1, POLB, PPARG, PTPN1, SRC, TRPV1 6.1536
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, BCL2, CNR1, CNR2, CYP1A1, CYP1B1, DRD1, HSP90AA1, KDR, POLB, SRC 6.10225
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, MIF, TBXAS1 6.01322
[BP] GO:0048513 animal organ development ACHE, AR, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, FLT3, HSD11B1, HSD17B2, HSP90AB1, KDR, POLB, PPARA, PPARG, SRC, TYR 5.79011
[BP] GO:0006690 icosanoid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, MIF, TBXAS1 5.79011
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, HSP90AB1, IGF1R, KDR, MCL1, MET, MIF, MMP9, PIM1, PPARA, PTPN1, SRC 5.71842
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALPL, APP, AR, AXL, BCL2, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, FABP4, FLT3, HSP90AB1, IGF1R, KDR, MMP2, MMP9, NR3C1, PPARG, SRC, TRPV1 5.65947
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, APP, AR, BCL2, CDC25B, CSNK2A1, CYP1B1, ESR1, FABP3, FLT3, IGF1R, KDR, MIF, MMP12, MMP2, MMP9, PGR, PIM1, PPARG, SRC, XDH 5.64862
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALPL, APP, AR, AXL, BCL2, CYP1A1, CYP1B1, DRD1, ESR1, FABP4, FLT3, HSP90AB1, IGF1R, KDR, MMP2, NR3C1, PPARG, SRC, TRPV1 5.64862
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA, PPARG, TRPV1 5.57322
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALPL, APP, AR, AURKB, AXL, BCL2, CA2, CA9, CDC25B, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, FABP4, FLT3, FUT7, HSD11B1, HSD17B2, HSP90AB1, KDR, MCL1, MET, MIF, MMP2, MMP9, PGR, PIM1, POLB, PPARA, PPARG, SRC, TYR 5.53447
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, HSP90AB1, IGF1R, KDR, MCL1, MET, MIF, MMP9, PIM1, PTPN1, SRC 5.53396
[BP] GO:0006631 fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, MIF, PPARA, PPARG, TBXAS1 5.53326
[BP] GO:0009755 hormone-mediated signaling pathway AR, ESR1, ESR2, NR3C1, NR3C2, PGR, PPARA, PPARG, SRC 5.52026
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.43561
[BP] GO:0030522 intracellular receptor signaling pathway AR, ESR1, ESR2, NR3C1, PGR, PIM1, PPARA, PPARG, SRC 5.35767
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, ESR1, ESR2, FABP3, FABP4, FLT3, HCAR2, HSP90AA1, HSP90AB1, IGF1R, KDR, MCL1, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR3C1, PGR, PIM1, PPARA, PPARG, PTPN1, SRC, TRPV1, XDH 5.35497
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD17B1, HSD17B2 5.18301
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DRD1, ESR1, ESR2, FLT3, HCAR2, HSP90AB1, IGF1R, KDR, MCL1, MET, MIF, MMP12, MMP9, PPARG, PTPN1, SRC, XDH 5.04325
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, FABP4, FUT7, MET, MIF, PPARA, PPARG, TBXAS1 4.97629
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALPL, APP, AR, AXL, BCL2, CA2, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, FLT3, HSD11B1, HSD17B2, HSP90AB1, KDR, MCL1, MMP9, PGR, PIM1, POLB, PPARA, PPARG, SRC, TYR 4.96356
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TBXAS1 4.95127
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DRD1, ESR1, ESR2, FLT3, HCAR2, HSP90AB1, IGF1R, KDR, MCL1, MET, MIF, MMP12, MMP9, PPARG, PTPN1, SRC, XDH 4.95127
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, HSP90AB1, IGF1R, KDR, MCL1, MIF, MMP9, PIM1, PTPN1, SRC 4.92184
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APP, CNR1, CNR2, DRD1, FABP3, FLT3, HSP90AB1, IGF1R, MMP2, PPARA, PPARG, SRC, TRPV1, TYR 4.7765
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, BCL2, CA2, CYP1A1, DRD1, HSP90AA1, HSP90AB1, MMP2, POLB, PPARA, PPARG, SRC, TRPV1, TYR 4.7677
[BP] GO:0010035 response to inorganic substance AKR1B1, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, MMP9, SRC 4.67705
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD11B1, HSD17B1, HSD17B2, PPARG, TBXAS1, TYR, XDH 4.67705
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, MIF, TBXAS1 4.67705
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7, CNR1, CNR2 4.609
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter AR, ESR1, ESR2, NR3C1, NR3C2, PGR, PPARA, PPARG 4.58593
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, BCL2, CA2, CA7, CNR1, DRD1, HCAR2, KDR, MIF, SRC, TRPV1 4.57409
[BP] GO:0080134 regulation of response to stress ADORA1, APP, CNR1, CNR2, CYP19A1, ESR1, FABP4, HSP90AA1, HSP90AB1, IGF1R, MCL1, MET, MIF, MMP12, MMP2, PPARA, PPARG, PTPN1, SRC, XDH 4.5564
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.55013
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, APP, AR, AXL, BCL2, CA2, CA7, CNR1, CSNK2A1, CYP19A1, CYP1B1, DRD1, HCAR2, HSP90AB1, IGF1R, KDR, MET, MIF, MMP12, MMP9, PPARA, PPARG, PTPN1, SRC, TRPV1 4.49988
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, AR, BCL2, CNR1, CNR2, CYP19A1, DRD1, ESR1, ESR2, IGF1R, MCL1, MET, MIF, MMP12, MMP9, PPARA, PPARG, PTPN1, SRC, XDH 4.45709
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, APP, AR, AXL, BCL2, CA1, CA2, CHRM2, CNR1, CNR2, CSNK2A1, CYP1B1, DRD1, ESR1, ESR2, FLT3, HCAR2, HSP90AA1, HSP90AB1, IGF1R, KDR, MCL1, MET, MIF, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, POLB, PPARA, PPARG, PTPN1, SRC, TRPV1 4.45709
[BP] GO:1901698 response to nitrogen compound AKR1B1, APP, CNR1, CNR2, DRD1, FABP3, FLT3, HSP90AB1, IGF1R, MMP2, PPARA, PPARG, SRC, TRPV1, TYR 4.41926
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.39375
[BP] GO:0022414 reproductive process AKR1B1, ALPL, APP, AR, AXL, BCL2, CDC25B, CNR1, CYP19A1, CYP1A1, DRD1, ESR1, HSD17B2, HSP90AB1, MMP2, MMP9, PGR, PPARG, SRC 4.39375
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CNR1, CYP19A1, CYP1A1, CYP1B1, ESR1, HCAR2, HSD11B1, HSD17B1, HSD17B2 4.29382
[BP] GO:0009892 negative regulation of metabolic process ADORA1, APP, AR, AURKB, BCL2, CNR1, CNR2, CSNK2A1, ESR1, ESR2, FABP4, HCAR2, HSP90AB1, IGF1R, KDR, MCL1, MET, MIF, MMP12, MMP9, NR3C1, PGR, PPARA, PPARG, PTPN1, SRC, TRPV1, XDH 4.18442
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, APP, AR, AURKB, AXL, BCL2, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD1, ESR1, ESR2, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, POLA1, POLB, PPARA, PPARG, PTPN1, SRC, TBXAS1, TRPV1, TYR, XDH 4.17646
[BP] GO:0030518 intracellular steroid hormone receptor signaling pathway AR, ESR1, ESR2, NR3C1, PGR, SRC 4.11461
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APP, AR, AXL, CYP1B1, DRD1, ESR1, IGF1R, MMP2, MMP9, NR3C1, PPARG, SRC, TRPV1 4.10345
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, AR, BCL2, CNR2, DRD1, ESR1, ESR2, IGF1R, MCL1, MET, MIF, MMP12, MMP9, PPARG, PTPN1, SRC, XDH 4.07149
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, AR, BCL2, CNR2, DRD1, ESR1, ESR2, IGF1R, MCL1, MET, MIF, MMP12, MMP9, PPARG, PTPN1, SRC, XDH 4.05594
[BP] GO:0008283 cell proliferation ACHE, AR, AURKB, BCL2, CYP1A1, ESR1, FLT3, MET, MIF, PIM1, POLA1, SRC, TYR 4.00403
[BP] GO:0048608 reproductive structure development AR, AXL, BCL2, CYP19A1, ESR1, HSD17B2, HSP90AB1, PPARG, SRC 3.99478
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APP, BCL2, CYP19A1, CYP1B1, DRD1, IGF1R, KDR, MET, MIF, MMP9, PPARG, SRC 3.99478
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CNR1, CNR2, CSNK2A1, CYP1B1, ESR1, FABP4, IGF1R, MET, MMP9, PIM1, PPARA, PPARG, PTPN1, SRC 3.9671
[BP] GO:0006352 DNA-templated transcription, initiation AR, ESR1, ESR2, NR3C1, NR3C2, PGR, PPARA, PPARG 3.87472
[BP] GO:0043393 regulation of protein binding APP, AURKB, BCL2, HSP90AB1, MET, MMP9, PPARA, SRC 3.87472
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, DRD1, HSP90AB1, KDR, NR3C1, SRC, TRPV1 3.87082
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, APP, AR, AXL, BCL2, CNR1, CNR2, CYP19A1, CYP1A2, CYP1B1, DRD1, ESR1, FABP4, HSD17B2, IGF1R, MCL1, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, SRC, TRPV1, TYR 3.85168
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, DRD1, KDR, SRC, TRPV1 3.84635
[BP] GO:0051972 regulation of telomerase activity AURKB, HSP90AA1, HSP90AB1, PPARG, SRC 3.79845
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, APP, AR, AXL, BCL2, CSNK2A1, CYP1B1, FLT3, HSP90AB1, KDR, MCL1, MET, MIF, MMP12, MMP9, PTPN1, SRC, XDH 3.75585
[BP] GO:0032787 None ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, MIF, PPARA, PPARG, TBXAS1 3.75108
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, APP, AR, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, FABP4, FLT3, HSP90AA1, HSP90AB1, KDR, MCL1, MET, MIF, MMP12, MMP2, MMP9, PTPN1, SRC, XDH 3.75108
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APP, BCL2, CYP19A1, CYP1B1, DRD1, IGF1R, KDR, MET, MIF, MMP9, PPARG, SRC 3.72304
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, MCL1, MIF, MMP9, PTPN1, SRC 3.6966
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, APP, AR, AURKB, AXL, BCL2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DRD1, ESR1, ESR2, FABP3, FABP4, HSP90AB1, IGF1R, KDR, MCL1, MET, MIF, MMP12, MMP9, NR3C1, PIM1, PPARA, PPARG, PTPN1, SRC, TRPV1, XDH 3.69478
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, ESR1, ESR2, FLT3, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, MIF, MMP12, MMP9, NR3C1, PGR, PPARA, PPARG, PTPN1, SRC, TRPV1, XDH 3.69478
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, APP, AXL, BCL2, CA2, CYP19A1, DRD1, HCAR2, HSP90AB1, MIF, MMP12, PPARG, SRC, TRPV1 3.66895
[BP] GO:0003006 developmental process involved in reproduction ALPL, AR, AXL, BCL2, CDC25B, CYP19A1, ESR1, HSD17B2, HSP90AB1, PGR, PPARG, SRC 3.66023
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, APP, AR, AURKB, AXL, BCL2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DRD1, ESR1, ESR2, FABP3, FABP4, HCAR2, HSP90AB1, IGF1R, KDR, MCL1, MET, MIF, MMP12, MMP9, NR3C1, PGR, PIM1, PPARA, PPARG, PTPN1, SRC, TRPV1, XDH 3.63911
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, APP, AR, AURKB, AXL, BCL2, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD1, ESR1, ESR2, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, POLA1, POLB, PPARA, PPARG, PTPN1, SRC, TBXAS1, TRPV1, TYR, XDH 3.63691
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, APP, AXL, BCL2, CA2, CA9, CNR2, CYP1A1, CYP1A2, CYP1B1, DRD1, HSP90AA1, HSP90AB1, MCL1, MIF, MMP2, MMP9, POLA1, POLB, PPARA, PPARG, PTPN1, SRC, TRPV1 3.63553
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, APP, AR, AURKB, BCL2, CDC25B, CNR1, CNR2, CSNK2A1, CYP1B1, DRD1, ESR1, ESR2, FABP4, FLT3, HSP90AA1, HSP90AB1, IGF1R, MET, MIF, MMP9, PIM1, PPARA, PPARG, PTPN1, SRC, TRPV1, XDH 3.62528
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, APP, AR, AXL, BCL2, CYP1B1, FLT3, KDR, MCL1, MET, MIF, PTPN1, SRC, XDH 3.61695
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.61302
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6 3.61302
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6 3.61302
[BP] GO:0001676 long-chain fatty acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TBXAS1 3.61263
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, APP, AR, AURKB, BCL2, CDC25B, DRD1, ESR1, ESR2, FABP3, FLT3, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, MIF, MMP12, MMP9, NR3C1, PGR, PPARA, PPARG, PTPN1, SRC, TRPV1, XDH 3.41557
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, AR, BCL2, CDC25B, CSNK2A1, ESR1, FLT3, IGF1R, KDR, MIF, MMP12, MMP2, MMP9, PIM1 3.4128
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, APP, AR, AURKB, BCL2, CDC25B, CNR1, CNR2, CSNK2A1, DRD1, ESR1, FABP4, FLT3, HSP90AA1, HSP90AB1, IGF1R, MIF, MMP9, PPARG, PTPN1, SRC, XDH 3.40281
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD17B1, HSD17B2 3.40038
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APP, BCL2, CYP19A1, CYP1B1, DRD1, IGF1R, KDR, MET, MIF, MMP9, PPARG, SRC 3.38801
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APP, BCL2, CYP19A1, CYP1B1, DRD1, IGF1R, KDR, MET, MIF, MMP9, PPARG, SRC 3.37427
[BP] GO:0046320 None CNR1, FABP3, PPARA, PPARG 3.36382
[BP] GO:0009893 positive regulation of metabolic process ADORA1, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, ESR1, ESR2, FABP3, FLT3, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, MIF, MMP12, MMP9, NR3C1, PGR, PPARA, PPARG, PTPN1, SRC, TRPV1, XDH 3.31242
[BP] GO:1901654 None AKR1B1, AR, CA9, CSNK2A1, NR3C1, PPARG, SRC 3.30223
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, FLT3, IGF1R, KDR, MCL1, MET, MIF, MMP9, PTPN1, SRC, XDH 3.28938
[BP] GO:0051098 regulation of binding APP, AURKB, BCL2, HSP90AB1, MET, MMP9, PPARA, PPARG, SRC 3.28938
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CNR1, CNR2, CYP19A1, DRD1, ESR1, FABP4, KDR, MET, MIF, MMP12, PPARA, PPARG 3.28938
[BP] GO:0031347 regulation of defense response ADORA1, CNR1, CNR2, CYP19A1, ESR1, FABP4, HSP90AB1, MMP12, MMP2, PPARA, PPARG, PTPN1, SRC 3.26884
[BP] GO:0035265 organ growth AR, BCL2, CYP19A1, ESR1 3.26492
[BP] GO:0048583 regulation of response to stimulus ADORA1, AKR1B1, APP, AR, AURKB, AXL, BCL2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DRD1, ESR1, ESR2, FABP4, FLT3, HSP90AA1, HSP90AB1, IGF1R, KDR, MCL1, MET, MIF, MMP12, MMP2, MMP9, PPARA, PPARG, PTPN1, SRC, XDH 3.26492
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, FABP4, FUT7, HSP90AA1, MMP1, MMP12, MMP2, MMP9, SRC, XDH 3.25248
[BP] GO:0009895 negative regulation of catabolic process ADORA1, BCL2, CNR1, HCAR2, HSP90AB1, MCL1, MET, PPARA 3.21845
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, HSP90AA1, IGF1R, KDR, MET, SRC 3.20764
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DRD1, FLT3, HSP90AA1, IGF1R, KDR, MET, PIM1, SRC 3.18475
[BP] GO:0002682 regulation of immune system process ADORA1, APP, AXL, BCL2, CA2, CNR1, CNR2, CYP19A1, ESR1, HCAR2, HSP90AA1, HSP90AB1, MIF, MMP12, MMP2, PPARG, PTPN1, SRC 3.18309
[BP] GO:0051049 regulation of transport ACHE, ADORA1, APP, AXL, BCL2, CA2, CA7, CNR1, CYP19A1, DRD1, HCAR2, HSP90AB1, MIF, MMP12, MMP9, PPARA, PPARG, PTPN1, SRC, TRPV1 3.18309
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APP, AR, DRD1, ESR1, FLT3, IGF1R, MMP2, NR3C1, PPARG, SRC, TRPV1 3.17933
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, HSP90AA1, IGF1R, KDR, MET, SRC 3.17549
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.1631
[BP] GO:0048878 chemical homeostasis AKR1B1, APP, BCL2, CA12, CA2, CA7, CNR1, DRD1, ESR1, FABP3, FABP4, MET, PPARG, TRPV1 3.15855
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CNR1, CYP1A1, FABP3, FLT3, HCAR2, PPARA, PPARG, SRC 3.13474
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC 3.08276
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, APP, AR, BCL2, CDC25B, DRD1, FABP3, FLT3, HSP90AB1, KDR, MIF, MMP9, PTPN1, SRC, XDH 3.08276
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, APP, AR, BCL2, CDC25B, DRD1, FABP3, FLT3, HSP90AB1, KDR, MIF, MMP9, PTPN1, SRC, XDH 3.08276
[BP] GO:0060736 prostate gland growth AR, CYP19A1, ESR1 3.04417
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, ESR1, PGR, PPARA, PPARG, SRC 3.01364
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX5, ALPL, APP, AR, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CHRM2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD1, ESR1, ESR2, FABP3, FABP4, FLT3, FUT7, HCAR2, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, IGF1R, KDR, MCL1, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, POLA1, POLB, PPARA, PPARG, PTPN1, SRC, TBXAS1, TRPV1, TYR, XDH 2.99172
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, MMP2, POLB, PPARA, PPARG, SRC 2.94661
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, ESR1, ESR2, FLT3, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, MIF, MMP12, MMP9, NR3C1, PGR, PPARA, PPARG, PTPN1, SRC, XDH 2.94534
[BP] GO:0019752 carboxylic acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, MIF, PIM1, PPARA, PPARG, TBXAS1, TYR 2.93242
[BP] GO:2001234 negative regulation of apoptotic signaling pathway AR, BCL2, MCL1, MIF, MMP9, PTPN1, SRC 2.90581
[BP] GO:1901655 None AKR1B1, AR, NR3C1, PPARG, SRC 2.89934
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, HSP90AA1, IGF1R, KDR, MET, MMP2, MMP9, PTPN1, SRC 2.89883
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, APP, CA2, CA7, CNR1, CNR2, DRD1 2.86183
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, APP, CA2, CA7, CNR1, CNR2, DRD1 2.86183
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, APP, AR, AURKB, BCL2, CA9, CDC25B, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, ESR2, FABP3, FABP4, FLT3, HCAR2, HSP90AA1, HSP90AB1, IGF1R, KDR, MCL1, MET, MIF, MMP12, MMP9, NR3C1, NR3C2, PGR, PIM1, POLA1, PPARA, PPARG, PTPN1, SRC, TRPV1, XDH 2.84891
[BP] GO:0042391 None ADORA1, APP, BCL2, CNR1, CNR2, DRD1, KDR, SRC, TRPV1 2.84891
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.84891
[BP] GO:0009891 positive regulation of biosynthetic process APP, AR, AURKB, DRD1, ESR1, ESR2, FABP3, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, MMP12, NR3C1, PGR, PPARA, PPARG, SRC, TRPV1 2.83511
[BP] GO:0048545 response to steroid hormone ALPL, AR, BCL2, CA2, FLT3, NR3C1, SRC 2.82902
[BP] GO:0009410 None CNR1, CNR2, DRD1, HSP90AB1, NR3C1, PPARG 2.81319
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, ESR1, IGF1R, MCL1, MET, MIF, MMP9, PTPN1, SRC, XDH 2.79565
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.76348
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, APP, BCL2, CYP19A1, CYP1A1, CYP1B1, DRD1, TYR 2.75269
[BP] GO:0042325 regulation of phosphorylation ADORA1, APP, AR, BCL2, CDC25B, DRD1, FABP4, FLT3, HSP90AB1, IGF1R, KDR, MIF, MMP9, PPARA, PTPN1, SRC, XDH 2.74773
[BP] GO:0051240 positive regulation of multicellular organismal process APP, AR, AXL, BCL2, CA2, CNR1, CYP1B1, HCAR2, KDR, MET, MIF, MMP12, MMP9, PIM1, PPARG, SRC, TRPV1 2.63896
[BP] GO:2001242 regulation of intrinsic apoptotic signaling pathway BCL2, MCL1, MIF, MMP9, PTPN1, SRC 2.63392
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, APP, AR, BCL2, CDC25B, DRD1, FABP4, FLT3, HSP90AB1, IGF1R, KDR, MIF, MMP9, PTPN1, SRC, XDH 2.62202
[BP] GO:0009991 response to extracellular stimulus ALPL, AXL, BCL2, CNR1, CYP1A1, PPARG, SRC, TRPV1, TYR 2.62202
[BP] GO:2000811 negative regulation of anoikis BCL2, MCL1, SRC 2.60034
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.60034
[BP] GO:0048609 multicellular organismal reproductive process AKR1B1, APP, AR, AXL, CNR1, CYP1A1, DRD1, ESR1, PGR, SRC 2.59101
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, APP, AR, BCL2, CDC25B, FLT3, HSP90AB1, KDR, MIF, MMP9, PTPN1, SRC, XDH 2.55094
[BP] GO:0043436 oxoacid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, MIF, PIM1, PPARA, PPARG, TBXAS1, TYR 2.54348
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, APP, AR, BCL2, CDC25B, DRD1, FABP3, FABP4, FLT3, HSP90AB1, IGF1R, KDR, MIF, MMP9, PPARA, PTPN1, SRC, XDH 2.53759
[BP] GO:0031324 negative regulation of cellular metabolic process APP, AR, AURKB, BCL2, CNR1, CSNK2A1, ESR1, ESR2, FABP4, HSP90AB1, IGF1R, MCL1, MET, MIF, MMP12, MMP9, NR3C1, PPARA, PPARG, PTPN1, SRC, TRPV1, XDH 2.53574
[BP] GO:0044093 positive regulation of molecular function ADORA1, APP, AR, AURKB, BCL2, CDC25B, ESR1, ESR2, FLT3, HSP90AA1, HSP90AB1, MET, MIF, MMP9, PPARG, PTPN1, SRC, XDH 2.51839
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, APP, AR, BCL2, CDC25B, DRD1, FABP3, FABP4, FLT3, HSP90AB1, IGF1R, KDR, MIF, MMP9, PPARA, PTPN1, SRC, XDH 2.49723
[BP] GO:2000377 regulation of reactive oxygen species metabolic process BCL2, CYP1B1, HSP90AA1, HSP90AB1, TRPV1, XDH 2.49649
[BP] GO:0006082 organic acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, MIF, PIM1, PPARA, PPARG, TBXAS1, TYR 2.47569
[BP] GO:0031348 negative regulation of defense response ADORA1, CNR2, CYP19A1, MMP12, PPARA, PPARG 2.47186
[BP] GO:1901652 response to peptide AKR1B1, APP, FABP3, IGF1R, PPARA, PPARG, SRC, TRPV1 2.47052
[BP] GO:0021700 developmental maturation APP, AXL, CDC25B, MMP2, PGR, PPARG 2.46168
[BP] GO:0050994 None ADORA1, CNR1, HCAR2, PPARA 2.45064
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, BCL2, CYP1B1, MMP9, SRC 2.441
[BP] GO:2000278 regulation of DNA biosynthetic process AURKB, HSP90AA1, HSP90AB1, PPARG, SRC 2.441
[BP] GO:0060748 None AR, PGR 2.43663
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.43663
[BP] GO:0031328 positive regulation of cellular biosynthetic process APP, AR, AURKB, DRD1, ESR1, ESR2, FABP3, HSP90AA1, HSP90AB1, IGF1R, MET, MMP12, NR3C1, PGR, PPARA, PPARG, SRC, TRPV1 2.4315
[BP] GO:0044236 multicellular organism metabolic process MMP1, MMP12, MMP2, MMP9, TRPV1 2.43092
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DRD1, FLT3, HSP90AA1, IGF1R, KDR, MET, PIM1, POLB, PTPN1, SRC, XDH 2.42062
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.41172
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, BCL2, CYP1B1, SRC 2.40145
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, SRC 2.40145
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, APP, AR, BCL2, CDC25B, FLT3, HSP90AB1, KDR, MIF, MMP9, PTPN1, SRC, XDH 2.40063
[BP] GO:0030336 None ADORA1, ADORA3, BCL2, CYP19A1, CYP1B1, MIF, PPARG 2.38454
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, APP, AXL, BCL2, CA1, CSNK2A1, FLT3, HSP90AA1, HSP90AB1, IGF1R, KDR, MCL1, MET, MIF, MMP2, MMP9, PTPN1, SRC, TRPV1 2.37351
[BP] GO:0006811 None CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD1, FABP3, PPARA, PPARG, TRPV1 2.37023
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DRD1, FLT3, HSP90AA1, IGF1R, KDR, MET, PIM1, SRC 2.34697
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 2.34057
[BP] GO:0071702 None ADORA1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD1, FABP3, HSP90AA1, MCL1, MMP12, PPARA, PPARG, TRPV1 2.30573
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, HSP90AB1 2.30383
[BP] GO:0051338 regulation of transferase activity ADORA1, APP, AURKB, CDC25B, FABP4, FLT3, HSP90AA1, HSP90AB1, IGF1R, MIF, PPARG, PTPN1, SRC 2.3005
[BP] GO:0055093 response to hyperoxia CYP1A1, POLB, PPARG 2.3005
[BP] GO:0043065 positive regulation of apoptotic process BCL2, CNR1, CYP1B1, HCAR2, MCL1, MMP9, PPARG, SRC, TRPV1, XDH 2.29302
[BP] GO:0050728 negative regulation of inflammatory response ADORA1, CNR2, CYP19A1, PPARA, PPARG 2.29293
[BP] GO:0051130 positive regulation of cellular component organization APP, AR, AURKB, AXL, BCL2, CNR1, ESR1, IGF1R, KDR, MET, MMP1, MMP9, PPARG, SRC 2.28485
[BP] GO:0032496 response to lipopolysaccharide ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, SRC 2.28485
[BP] GO:0032102 negative regulation of response to external stimulus ADORA1, CNR2, CYP19A1, DRD1, MIF, PPARA, PPARG 2.26695
[BP] GO:0043068 positive regulation of programmed cell death BCL2, CNR1, CYP1B1, HCAR2, MCL1, MMP9, PPARG, SRC, TRPV1, XDH 2.26628
[BP] GO:2000146 None ADORA1, ADORA3, BCL2, CYP19A1, CYP1B1, MIF, PPARG 2.2607
[BP] GO:0051047 None ACHE, ADORA1, CYP19A1, HCAR2, MIF, MMP12, SRC, TRPV1 2.25572
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.2556
[BP] GO:0050995 None ADORA1, CNR1, HCAR2 2.2556
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, DRD1, MET, TRPV1 2.25541
[BP] GO:0002009 morphogenesis of an epithelium AR, BCL2, CA2, CA9, ESR1, MET, SRC 2.25214
[BP] GO:0007584 response to nutrient ALPL, CNR1, CYP1A1, PPARG, TRPV1, TYR 2.25214
[BP] GO:0009968 negative regulation of signal transduction AR, BCL2, ESR1, ESR2, IGF1R, MCL1, MET, MIF, MMP12, MMP9, PPARG, PTPN1, SRC, XDH 2.25214
[BP] GO:0051090 regulation of DNA binding transcription factor activity ADORA3, APP, AR, CYP1B1, ESR1, ESR2, PIM1, PPARG 2.22385
[BP] GO:0050727 regulation of inflammatory response ADORA1, CNR1, CNR2, CYP19A1, ESR1, FABP4, PPARA, PPARG 2.22385
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, APP, CA2, CA7, DRD1 2.21544
[BP] GO:2000209 regulation of anoikis BCL2, MCL1, SRC 2.21298
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.21298
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DRD1, FLT3, HSP90AA1, IGF1R, KDR, MET, PIM1, POLB, PTPN1, SRC, XDH 2.21124
[BP] GO:1905323 None HSP90AA1, HSP90AB1 2.21124
[BP] GO:0038171 None CNR1, CNR2 2.21124
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.21124
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, PPARA, PPARG, SRC 2.19485
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APP, DRD1, IGF1R, MMP2, PPARG, SRC, TRPV1 2.18704
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, CNR2, DRD1 2.18704
[BP] GO:2000573 positive regulation of DNA biosynthetic process AURKB, HSP90AA1, HSP90AB1, SRC 2.18704
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, APP, AR, FLT3, KDR, MIF, PTPN1, SRC, XDH 2.18375
[BP] GO:0035902 response to immobilization stress CYP1A1, CYP1A2, PPARG 2.17846
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.17846
[BP] GO:0006810 None ACHE, ADORA1, ALOX5, APP, AR, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD1, FABP3, HSP90AA1, HSP90AB1, MCL1, MIF, MMP12, MMP9, PPARA, PPARG, SRC, TRPV1, XDH 2.17846
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.17152
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, APP, AR, AURKB, BCL2, CA9, CDC25B, CNR1, CSNK2A1, CYP1A1, CYP1B1, DRD1, ESR1, ESR2, FABP3, FABP4, FLT3, HCAR2, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, MIF, MMP12, MMP9, NR3C1, NR3C2, PGR, PIM1, POLA1, PPARA, PPARG, PTPN1, SRC, TRPV1, XDH 2.17152
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD17B1, HSD17B2 2.16278
[BP] GO:0051271 None ADORA1, ADORA3, BCL2, CYP19A1, CYP1B1, MIF, PPARG 2.16221
[BP] GO:0002237 response to molecule of bacterial origin ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, SRC 2.16221
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process APP, AR, AURKB, DRD1, ESR1, ESR2, HSP90AA1, HSP90AB1, IGF1R, MET, MMP12, NR3C1, PGR, PPARA, PPARG, PTPN1, SRC 2.15805
[BP] GO:0048469 cell maturation APP, AXL, CDC25B, PGR, PPARG 2.13816
[BP] GO:0031667 response to nutrient levels ALPL, BCL2, CNR1, CYP1A1, PPARG, SRC, TRPV1, TYR 2.13604
[BP] GO:0002683 negative regulation of immune system process ADORA1, AXL, CNR1, CNR2, CYP19A1, MIF, MMP12, PPARG 2.13015
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, APP, AR, AXL, BCL2, CA2, CHRM2, CNR1, CYP1B1, ESR1, HCAR2, HSP90AB1, KDR, MET, MIF, MMP12, MMP9, PIM1, PPARG, SRC, TRPV1, XDH 2.08694
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, ESR2, FLT3, HSP90AB1, IGF1R, KDR, MCL1, MET, MIF, MMP12, MMP9, PPARG, PTPN1, SRC, XDH 2.08378
[BP] GO:0030198 extracellular matrix organization APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 2.07007
[BP] GO:0010942 positive regulation of cell death BCL2, CNR1, CYP1B1, HCAR2, MCL1, MMP9, PPARG, SRC, TRPV1, XDH 2.06698
[BP] GO:0043062 extracellular structure organization APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 2.06433
[BP] GO:0040013 None ADORA1, ADORA3, BCL2, CYP19A1, CYP1B1, MIF, PPARG 2.06007
[BP] GO:0048869 cellular developmental process ACHE, ALPL, APP, AR, AXL, BCL2, CDC25B, CYP1A1, DRD1, ESR1, FABP4, FLT3, FUT7, KDR, MCL1, MET, MIF, MMP2, MMP9, PGR, PPARG, SRC 2.05771
[BP] GO:0032800 receptor biosynthetic process ACHE, PPARG 2.04552
[BP] GO:0010891 None PPARA, PPARG 2.04552
[BP] GO:0031099 regeneration AXL, BCL2, CSNK2A1, FLT3, PPARG 2.0437
[BP] GO:0031399 regulation of protein modification process ADORA1, APP, AR, BCL2, CDC25B, DRD1, FABP4, FLT3, HSP90AA1, HSP90AB1, IGF1R, KDR, MIF, MMP9, PTPN1, SRC, XDH 2.04252
[BP] GO:0048010 vascular endothelial growth factor receptor signaling pathway AXL, HSP90AA1, KDR, SRC 2.04001
[BP] GO:0036296 response to increased oxygen levels CYP1A1, POLB, PPARG 2.02252
[BP] GO:0033032 regulation of myeloid cell apoptotic process BCL2, HCAR2, MIF 2.02252
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, FLT3, HSP90AA1, IGF1R, KDR, MET, MMP2, MMP9, PTPN1, SRC 2.02252
[BP] GO:0044243 multicellular organismal catabolic process MMP1, MMP12, MMP2, MMP9 2.02236
[BP] GO:0090087 None ACHE, ADORA1, APP, CA2, CNR1, HCAR2, HSP90AB1, MIF, MMP12, PTPN1, SRC 2.02071
[BP] GO:0001775 cell activation ALOX5, APP, AXL, BCL2, FLT3, FUT7, HSP90AA1, HSP90AB1, MIF, MMP9, SRC, TRPV1 2.01288
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APP, DRD1, IGF1R, MMP2, PPARG, SRC, TRPV1 2.01151
[BP] GO:0010038 response to metal ion APP, BCL2, CA2, CYP1A1, CYP1A2, FABP4, MMP9 2.00893
[BP] GO:0071383 None AR, FLT3, NR3C1, SRC 2.00636
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, APP, AR, AURKB, BCL2, CA9, CDC25B, CNR1, CSNK2A1, CYP1B1, DRD1, ESR1, ESR2, FABP3, FABP4, FLT3, HSP90AA1, HSP90AB1, IGF1R, KDR, MCL1, MET, MIF, MMP12, MMP9, NR3C1, NR3C2, PGR, PIM1, POLA1, PPARA, PPARG, PTPN1, SRC, TRPV1, XDH 2.00504
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APP, AR, AURKB, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA7, CDC25B, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD1, ESR1, ESR2, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, KDR, MCL1, MIF, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, POLA1, PPARG, PTPN1, SRC, TBXAS1, TRPV1, TYR, XDH 3.87082
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ALOX5, ALPL, APP, AR, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD1, ESR1, FLT3, FUT7, HCAR2, HSD11B1, HSD17B2, HSP90AA1, HSP90AB1, IGF1R, KDR, MCL1, MET, MMP2, NR3C2, PGR, PIM1, PTPN1, SRC, TBXAS1, TRPV1, TYR 2.87376
[CC] GO:0031253 None ADORA1, CA4, CA9, DRD1, HSP90AA1, HSP90AB1, SRC, TRPV1 2.74884
[CC] GO:0044432 endoplasmic reticulum part APP, BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD1, FLT3, HSD11B1, HSD17B2, NR3C2, PTPN1, TBXAS1 2.40512
[CC] GO:1904813 None ALOX5, HSP90AA1, HSP90AB1, MIF, MMP9 2.18463
[CC] GO:0005789 endoplasmic reticulum membrane BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD1, HSD11B1, HSD17B2, NR3C2, TBXAS1 2.14881
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, ALPL, APP, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM2, CNR1, CNR2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD1, ESR1, FLT3, FUT7, HCAR2, HSD11B1, HSD17B2, HSP90AA1, HSP90AB1, IGF1R, KDR, MCL1, MET, NR3C2, PTPN1, SRC, TBXAS1, TRPV1, TYR 2.10066
[MF] GO:0046914 transition metal ion binding ALOX5, APP, AR, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PPARA, PPARG, PTPN1, TBXAS1, TYR, XDH 19.6544
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 17.2584
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, POLB 11.0515
[MF] GO:0043167 ion binding ACHE, ALOX5, ALPL, APP, AR, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD1, ESR1, ESR2, FABP3, FABP4, FLT3, HSD17B1, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, POLA1, POLB, PPARA, PPARG, PTPN1, SRC, TBXAS1, TRPV1, TYR, XDH 11.0515
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.9347
[MF] GO:0008270 zinc ion binding AR, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR1, ESR2, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PPARA, PPARG, PTPN1 10.137
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD1, ESR1, ESR2, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, POLA1, POLB, PPARA, PPARG, PTPN1, TBXAS1, TRPV1, TYR, XDH 8.46555
[MF] GO:0003707 steroid hormone receptor activity AR, ESR1, ESR2, NR3C1, NR3C2, PGR, PPARA, PPARG 7.47982
[MF] GO:0046872 metal ion binding ALOX5, ALPL, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, POLA1, POLB, PPARA, PPARG, PTPN1, TBXAS1, TRPV1, TYR, XDH 7.45842
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FLT3, FUT7, HSD11B1, HSD17B1, HSD17B2, HSP90AA1, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIM1, POLA1, POLB, PTPN1, SRC, TBXAS1, TYR, XDH 7.41114
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, POLB 7.36992
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 6.60845
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TBXAS1, TYR 6.07596
[MF] GO:0005506 iron ion binding ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TBXAS1, XDH 5.63502
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AR, AXL, CHRM2, CNR1, CNR2, DRD1, ESR1, ESR2, FLT3, HCAR2, IGF1R, KDR, MET, NR3C1, NR3C2, PGR, PPARA, PPARG, TRPV1 5.54726
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, DRD1, FLT3, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, PIM1, PPARA, PPARG, SRC, TRPV1 5.29565
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 5.24855
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, SRC, TBXAS1 5.21169
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding AR, ESR1, ESR2, PGR, PPARA, PPARG 5.16734
[MF] GO:0004879 nuclear receptor activity AR, ESR1, ESR2, PGR, PPARA, PPARG 5.16734
[MF] GO:0005496 steroid binding AR, ESR1, ESR2, HSD17B1, NR3C1, NR3C2, PGR 5.11995
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, SRC, TBXAS1 4.99492
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD11B1, HSD17B1, HSD17B2, TBXAS1, TYR, XDH 4.97974
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AR, AXL, CHRM2, CNR1, CNR2, DRD1, ESR1, ESR2, FLT3, HCAR2, IGF1R, KDR, MET, NR3C1, NR3C2, PGR, PPARA, PPARG, TRPV1 4.78351
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TBXAS1, TYR 4.67705
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AR, AXL, CHRM2, CNR1, CNR2, DRD1, ESR1, ESR2, FLT3, HCAR2, IGF1R, KDR, MET, NR3C1, NR3C2, PGR, PPARA, PPARG, TRPV1 4.59185
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AR, AXL, CHRM2, CNR1, CNR2, DRD1, ESR1, ESR2, FLT3, HCAR2, IGF1R, KDR, MET, NR3C1, NR3C2, PGR, PPARA, PPARG, TRPV1 4.17279
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 3.95192
[MF] GO:0042802 identical protein binding ACHE, APP, BCL2, CSNK2A1, ESR1, ESR2, FLT3, HSP90AA1, HSP90AB1, IGF1R, KDR, MCL1, MET, MIF, MMP9, PGR, PPARG, TRPV1, TYR, XDH 3.90793
[MF] GO:0008289 lipid binding AR, AXL, ESR1, ESR2, FABP3, FABP4, HSD17B1, NR3C1, NR3C2, PGR, PPARA, PPARG, TRPV1 3.87463
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD17B1, POLA1, SRC, TBXAS1, XDH 3.72304
[MF] GO:0030235 nitric-oxide synthase regulator activity ESR1, HSP90AA1, HSP90AB1 3.61302
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.37427
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, HSP90AA1, IGF1R, KDR, MET, SRC 3.26884
[MF] GO:0019899 enzyme binding APP, AR, AURKB, BCL2, CDC25B, CYP1A1, CYP1A2, CYP2A6, ESR1, ESR2, HSP90AA1, HSP90AB1, MET, MIF, NR3C1, PGR, POLA1, POLB, PPARA, PPARG, PTPN1, SRC 3.24225
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6 3.08276
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, CSNK2A1, FLT3, HSP90AA1, HSP90AB1, IGF1R, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SRC 2.96133
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, HSD11B1, HSD17B1, HSD17B2, XDH 2.94661
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 2.94534
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.83896
[MF] GO:0008389 None CYP2A13, CYP2A6 2.83896
[MF] GO:0042562 hormone binding ACHE, AR, HSD17B1, IGF1R, NR3C1 2.82487
[MF] GO:0032403 protein complex binding ACHE, ADORA1, FLT3, HSP90AA1, HSP90AB1, IGF1R, KDR, MMP12, MMP9, PPARA, PTPN1, SRC 2.62202
[MF] GO:0031072 heat shock protein binding ADORA1, CSNK2A1, HSP90AB1, KDR, NR3C1 2.441
[MF] GO:0004949 None CNR1, CNR2 2.43663
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, HSD11B1, HSD17B1, HSD17B2 2.2448
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.21124
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, FLT3, HSP90AA1, IGF1R, KDR, MET, PIM1, SRC 2.10283
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, AXL, CHRM2, CNR1, CNR2, DRD1, FLT3, HCAR2, IGF1R, KDR, MET, PPARG, TRPV1 2.06007
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, AXL, CHRM2, CNR1, CNR2, DRD1, FLT3, HCAR2, IGF1R, KDR, MET, PPARG, TRPV1 2.06007
[MF] GO:0005504 None FABP3, FABP4, PPARG 2.05709
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD17B1, HSD17B2 2.05709
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.04552
[MF] GO:0051434 BH3 domain binding BCL2, MCL1 2.04552


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 18.5006
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 7.5869
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 7.2938
Pathways in cancer_Homo sapiens_hsa05200 AR, HSP90AA1, HSP90AB1, FLT3, MMP1, MMP2, BCL2, PPARG, MMP9, MET, IGF1R 5.5342
Estrogen signaling pathway_Homo sapiens_hsa04915 HSP90AA1, HSP90AB1, SRC, MMP2, MMP9, ESR1, ESR2 5.7724
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 5.3588
Metabolic pathways_Homo sapiens_hsa01100 AKR1B1, TYR, CYP19A1, HSD11B1, POLA1, CYP2A6, FUT7, AKR1B10, ALOX5, HSD17B1, TBXAS1, HSD17B2, CYP1A2, CYP1A1, ALPL, XDH 4.2618
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 5.1741
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, ESR1, IGF1R 4.1752
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, CNR2, CNR1, ADORA3, ADORA1, TRPV1, DRD1, NR3C1 4.2122
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MET, IGF1R 4.1904
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, HSP90AA1, HSP90AB1, KDR, BCL2, MET, MCL1, IGF1R 3.7445
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARG, PPARA 4.2618
Prostate cancer_Homo sapiens_hsa05215 AR, HSP90AA1, HSP90AB1, BCL2, IGF1R 3.8935
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 HSP90AA1, HSP90AB1, PGR, CDC25B, IGF1R 3.7445
MicroRNAs in cancer_Homo sapiens_hsa05206 BCL2, PIM1, CYP1B1, MMP9, MET, CDC25B, MCL1 3.2561
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 3.9326
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, HCAR2, ADORA1, DRD1, PPARA 2.3917
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, PPARG, MMP9, MET, IGF1R 2.5688
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, BCL2, MET, IGF1R 2.3825
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, CNR1, KDR, MET, IGF1R 2.3166
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1 2.5926
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 1.9654
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, BCL2, PIM1 1.5991
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1 2.0753
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, BCL2 1.5327
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.3294
Oocyte meiosis_Homo sapiens_hsa04114 AR, PGR, IGF1R 1.4476
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, BCL2, ADORA1 1.4639
Hepatitis B_Homo sapiens_hsa05161 SRC, BCL2, MMP9 1.2837
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1, MCL1 1.2389
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 HSP90AA1, HSP90AB1, BCL2 1.2011
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1 1.246
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.246
Ras signaling pathway_Homo sapiens_hsa04014 KDR, MET, IGF1R 0.978
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.2218
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 0.9996
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET 1.1748
Melanoma_Homo sapiens_hsa05218 MET, IGF1R 1.1553
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.2389
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC, TRPV1 0.9727
NOD-like receptor signaling pathway_Homo sapiens_hsa04621 HSP90AA1, HSP90AB1 1.246
Morphine addiction_Homo sapiens_hsa05032 ADORA1, DRD1 0.9996
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 PPARG, IGF1R 0.9897
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.1721
Gap junction_Homo sapiens_hsa04540 SRC, DRD1 1.0096
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.0971
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 0.8854
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PPARA 0.9119
HIF-1 signaling pathway_Homo sapiens_hsa04066 BCL2, IGF1R 0.9485
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, TBXAS1 1.2185
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2 0.9905
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, CYP1A2 1.1694
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.6139
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, XDH 1.3656
Antigen processing and presentation_Homo sapiens_hsa04612 HSP90AA1, HSP90AB1 1.0988
Tyrosine metabolism_Homo sapiens_hsa00350 MIF, TYR 1.5327
Serotonergic synapse_Homo sapiens_hsa04726 APP, ALOX5 0.9052
Platelet activation_Homo sapiens_hsa04611 SRC, TBXAS1 0.8732
Apoptosis_Homo sapiens_hsa04210 BCL2, MCL1 0.7889
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, ESR1 0.8854
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2 0.8854
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.8854
AMPK signaling pathway_Homo sapiens_hsa04152 PPARG, IGF1R 0.8671
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.7889
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1 0.7011
Purine metabolism_Homo sapiens_hsa00230 POLA1, XDH 0.6759
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, DRD1 0.6749
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2 0.6101
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.6759
Viral carcinogenesis_Homo sapiens_hsa05203 POLB, SRC 0.6101
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, SRC 0.5907
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.5899
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.5327
HTLV-I infection_Homo sapiens_hsa05166 POLB 0.2274
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.2274
Huntington's disease_Homo sapiens_hsa05016 PPARG 0.3049
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3114
Alcoholism_Homo sapiens_hsa05034 DRD1 0.3185
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.3113
Parkinson's disease_Homo sapiens_hsa05012 DRD1 0.3773
Alzheimer's disease_Homo sapiens_hsa05010 APP 0.3354
Measles_Homo sapiens_hsa05162 CSNK2A1 0.378
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2 0.3667
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1 0.3773
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.3635
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC 0.3519
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 IGF1R 0.3773
Osteoclast differentiation_Homo sapiens_hsa04380 PPARG 0.3821
FoxO signaling pathway_Homo sapiens_hsa04068 IGF1R 0.3821
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.3773
Neurotrophin signaling pathway_Homo sapiens_hsa04722 BCL2 0.3959
Cell cycle_Homo sapiens_hsa04110 CDC25B 0.3882
Hepatitis C_Homo sapiens_hsa05160 PPARA 0.3821
Axon guidance_Homo sapiens_hsa04360 MET 0.3835
Dopaminergic synapse_Homo sapiens_hsa04728 DRD1 0.3821
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.423
Melanogenesis_Homo sapiens_hsa04916 TYR 0.4461
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4461
Pyrimidine metabolism_Homo sapiens_hsa00240 POLA1 0.4359
ErbB signaling pathway_Homo sapiens_hsa04012 SRC 0.469
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 CNR1 0.4461
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.453
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.453
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.8262
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.4689
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.469
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.469
Small cell lung cancer_Homo sapiens_hsa05222 BCL2 0.469
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4689
Peroxisome_Homo sapiens_hsa04146 XDH 0.4743
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5134
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5261
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.5414
Bile secretion_Homo sapiens_hsa04976 CA2 0.5249
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5399
Glioma_Homo sapiens_hsa05214 IGF1R 0.5414
Amphetamine addiction_Homo sapiens_hsa05031 DRD1 0.5385
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.5493
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.5414
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 5.1741
Colorectal cancer_Homo sapiens_hsa05210 BCL2 0.5414
Shigellosis_Homo sapiens_hsa05131 SRC 0.5414
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.6038
Malaria_Homo sapiens_hsa05144 MET 0.6101
Cocaine addiction_Homo sapiens_hsa05030 DRD1 0.6101
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6112
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 NR3C2 0.6759
Thyroid cancer_Homo sapiens_hsa05216 PPARG 0.7587
DNA replication_Homo sapiens_hsa03030 POLA1 0.6925
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7368
Base excision repair_Homo sapiens_hsa03410 POLB 0.7169
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.7587
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.7862
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.7765
Phenylalanine metabolism_Homo sapiens_hsa00360 MIF 0.9052
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 0.9598


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)