NPASS Compound

Structure

CID228343 OpenBabel06191716022D 22 23 0 0 1 0 0 0 0 0999 V2000 -2.5981 -1.5000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -1.7321 -4.0000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -5.1962 -3.0000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -1.7321 -1.0000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -6.0622 -2.5000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -1.7321 -0.0000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -3.4641 -3.0000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -0.8660 -2.5000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -4.3301 -1.5000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -0.0000 -1.0000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -2.5981 -2.5000 0.0000 C 0 0 3 0 0 0 0 0 0 0 0 0 -1.7321 -3.0000 0.0000 C 0 0 3 0 0 0 0 0 0 0 0 0 -4.3301 -2.5000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -0.8660 -1.5000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -6.0622 -1.5000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -0.8660 0.5000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -5.1962 -1.0000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 -0.0000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -6.9282 -1.0000 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 -0.8660 1.5000 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 -5.1962 0.0000 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 0.8660 0.5000 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 1 11 1 0 0 0 0 2 12 1 0 0 0 0 3 5 2 0 0 0 0 3 13 1 0 0 0 0 4 6 2 0 0 0 0 4 14 1 0 0 0 0 5 15 1 0 0 0 0 6 16 1 0 0 0 0 7 11 1 0 0 0 0 7 13 1 0 0 0 0 8 12 1 0 0 0 0 8 14 1 0 0 0 0 9 13 2 0 0 0 0 9 17 1 0 0 0 0 10 14 2 0 0 0 0 10 18 1 0 0 0 0 11 12 1 0 0 0 0 15 17 2 0 0 0 0 15 19 1 0 0 0 0 16 18 2 0 0 0 0 16 20 1 0 0 0 0 17 21 1 0 0 0 0 18 22 1 0 0 0 0 M END $$$$

Physi-Chem Properties

Molecular Weight:	302.15
Volume:	322.113
LogP:	3.441
LogD:	3.588
LogS:	-3.172
# Rotatable Bonds:	5
TPSA:	80.92
# H-Bond Aceptor:	4
# H-Bond Donor:	4
# Rings:	2
# Heavy Atoms:	4

MedChem Properties

QED Drug-Likeness Score:	0.637
Synthetic Accessibility Score:	3.027
Fsp3:	0.333
Lipinski Rule-of-5:	Accepted
Pfizer Rule:	Accepted
GSK Rule:	Accepted
BMS Rule:	0
Golden Triangle Rule:	Accepted
Chelating Alert:	1
PAINS Alert:	1

ADMET Properties (ADMETlab2.0)

ADMET: Absorption

Caco-2 Permeability:	-4.781
MDCK Permeability:	1.3083804333291482e-05
Pgp-inhibitor:	0.014
Pgp-substrate:	0.003
Human Intestinal Absorption (HIA):	0.011
20% Bioavailability (F20%):	0.954
30% Bioavailability (F30%):	0.985

ADMET: Distribution

Blood-Brain-Barrier Penetration (BBB):	0.031
Plasma Protein Binding (PPB):	98.20771789550781%
Volume Distribution (VD):	0.811
Pgp-substrate:	1.3446379899978638%

ADMET: Metabolism

CYP1A2-inhibitor:	0.729
CYP1A2-substrate:	0.884
CYP2C19-inhibitor:	0.663
CYP2C19-substrate:	0.065
CYP2C9-inhibitor:	0.697
CYP2C9-substrate:	0.901
CYP2D6-inhibitor:	0.822
CYP2D6-substrate:	0.861
CYP3A4-inhibitor:	0.157
CYP3A4-substrate:	0.398

ADMET: Excretion

Clearance (CL):	24.056
Half-life (T1/2):	0.9

ADMET: Toxicity

hERG Blockers:	0.011
Human Hepatotoxicity (H-HT):	0.062
Drug-inuced Liver Injury (DILI):	0.152
AMES Toxicity:	0.399
Rat Oral Acute Toxicity:	0.273
Maximum Recommended Daily Dose:	0.425
Skin Sensitization:	0.959
Carcinogencity:	0.241
Eye Corrosion:	0.008
Eye Irritation:	0.949
Respiratory Toxicity:	0.198

Download Data

Data Type	Select
General Info & Identifiers & Properties
Structure MOL file
Source Organisms
Biological Activities
Similar NPs/Drugs

Natural Product: NPC228343

Natural Product ID:	NPC228343
*Common Name:**	Nordihydroguaiaretic Acid
IUPAC Name:	4-[4-(3,4-dihydroxyphenyl)-2,3-dimethylbutyl]benzene-1,2-diol
Synonyms:	Actinex; CHX-100; Masoprocol; MESO-NDGA; Meso-Nordihydroguaiaretic Acid; Nordihydroguaiaretic acid
Standard InCHIKey:	HCZKYJDFEPMADG-UHFFFAOYSA-N
Standard InCHI:	InChI=1S/C18H22O4/c1-11(7-13-3-5-15(19)17(21)9-13)12(2)8-14-4-6-16(20)18(22)10-14/h3-6,9-12,19-22H,7-8H2,1-2H3
SMILES:	CC(C(Cc1ccc(c(c1)O)O)C)Cc1ccc(c(c1)O)O
Synthetic Gene Cluster:	n.a.
ChEMBL Identifier:	CHEMBL52
PubChem CID:	4534
Chemical Classification:**	CHEMONTID:0000000 [Organic compounds] [CHEMONTID:0001392] Lignans, neolignans and related compounds [CHEMONTID:0001969] Dibenzylbutane lignans

*Note: the InCHIKey will be temporarily assigned as the "Common Name" if no IUPAC name or alternative short name is available.
**Note: the Chemical Classification was calculated by NPClassifier Version 1.5. Reference: PMID:34662515.

Species Source

Organism ID	Organism Name	Taxonomy Level	Family	SuperKingdom	Isolation Part	Collection Location	Collection Time	Reference
NPO8187	Schisandra chinensis	Species	Schisandraceae	Eukaryota	n.a.	n.a.	n.a.	PMID[16562834]
NPO8187	Schisandra chinensis	Species	Schisandraceae	Eukaryota	n.a.	fruit	n.a.	PMID[24155209]
NPO8187	Schisandra chinensis	Species	Schisandraceae	Eukaryota	n.a.	n.a.	n.a.	PMID[24959987]
NPO8187	Schisandra chinensis	Species	Schisandraceae	Eukaryota	n.a.	n.a.	n.a.	PMID[25302569]
NPO17416	Santolina oblongifolia	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	PMID[8988605]
NPO8187	Schisandra chinensis	Species	Schisandraceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO8187	Schisandra chinensis	Species	Schisandraceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO8187	Schisandra chinensis	Species	Schisandraceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO8187	Schisandra chinensis	Species	Schisandraceae	Eukaryota	n.a.	n.a.	n.a.	Database[TM-MC]
NPO17416	Santolina oblongifolia	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO8187	Schisandra chinensis	Species	Schisandraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]

☑ Note for Reference:
In addition to directly collecting NP source organism data from primary literature (where reference will provided as NCBI PMID or DOI links), NPASS also integrated them from below databases:
☉ UNPD: Universal Natural Products Database [PMID: 23638153].
☉ StreptomeDB: a database of streptomycetes natural products [PMID: 33051671].
☉ TM-MC: a database of medicinal materials and chemical compounds in Northeast Asian traditional medicine [PMID: 26156871].
☉ TCM@Taiwan: a Traditional Chinese Medicine database [PMID: 21253603].
☉ TCMID: a Traditional Chinese Medicine database [PMID: 29106634].
☉ TCMSP: The traditional Chinese medicine systems pharmacology database and analysis platform [PMID: 24735618].
☉ HerDing: a herb recommendation system to treat diseases using genes and chemicals [PMID: 26980517].
☉ MetaboLights: a metabolomics database [PMID: 27010336].
☉ FooDB: a database of constituents, chemistry and biology of food species [www.foodb.ca].

NP Quantity Composition/Concentration

Organism ID	NP ID	Organism Material Preparation	Organism Part	NP Quantity (Standard)	NP Quantity (Minimum)	NP Quantity (Maximum)	Quantity Unit	Reference

☑ Note for Reference:
In addition to directly collecting NP quantitative data from primary literature (where reference will provided as NCBI PMID or DOI links), NPASS also integrated NP quantitative records for specific NP domains (e.g., NPS from foods or herbs) from domain-specific databases. These databases include:
☉ DUKE: Dr. Duke's Phytochemical and Ethnobotanical Databases.
☉ PHENOL EXPLORER: is the first comprehensive database on polyphenol content in foods [PMID: 24103452], its homepage can be accessed at here.
☉ FooDB: a database of constituents, chemistry and biology of food species [www.foodb.ca].

Biological Activity

Activity Type	# Activity
AC50	1
EC50	15
ED50	6
GI50	60
IC50	153
LD50	1
Others	1225
Potency	121

Activity Type	# Activity
Cell Line	1120
CELL-LINE	2
Individual Protein	185
NON-MOLECULAR	14
Organism	44
Others	189
PHENOTYPE	12
PROTEIN COMPLEX	2
Protein Family	5
Protein-Protein Interaction	3
SINGLE PROTEIN	6
Subcellular	1

Target ID	Target Type	Target Name	Target Organism	Activity Type	Activity Relation	Value	Unit	Reference
NPT183	Individual Protein	Arachidonate 5-lipoxygenase	Rattus norvegicus	IC50	=	400.0	nM	PMID[453615]
NPT183	Individual Protein	Arachidonate 5-lipoxygenase	Rattus norvegicus	IC50	=	120.0	nM	PMID[453616]
NPT1119	Individual Protein	Arachidonate 12-lipoxygenase	Homo sapiens	IC50	=	5000.0	nM	PMID[453617]
NPT183	Individual Protein	Arachidonate 5-lipoxygenase	Rattus norvegicus	IC50	=	400.0	nM	PMID[453617]
NPT3068	Individual Protein	Leukotriene B4 receptor 1	Homo sapiens	IC50	=	85.0	nM	PMID[453619]
NPT183	Individual Protein	Arachidonate 5-lipoxygenase	Rattus norvegicus	Inhibition	=	60.0	%	PMID[453620]
NPT183	Individual Protein	Arachidonate 5-lipoxygenase	Rattus norvegicus	IC50	=	5000.0	nM	PMID[453621]
NPT570	Individual Protein	Arachidonate 5-lipoxygenase	Homo sapiens	EC50	>	100.0	mg kg-1	PMID[453621]
NPT183	Individual Protein	Arachidonate 5-lipoxygenase	Rattus norvegicus	IC50	=	410.0	nM	PMID[453622]
NPT183	Individual Protein	Arachidonate 5-lipoxygenase	Rattus norvegicus	Inhibition	=	73.0	%	PMID[453622]
NPT183	Individual Protein	Arachidonate 5-lipoxygenase	Rattus norvegicus	IC50	=	150.0	nM	PMID[453623]
NPT1119	Individual Protein	Arachidonate 12-lipoxygenase	Homo sapiens	IC50	=	5100.0	nM	PMID[453624]
NPT570	Individual Protein	Arachidonate 5-lipoxygenase	Homo sapiens	IC50	=	160.0	nM	PMID[453625]
NPT183	Individual Protein	Arachidonate 5-lipoxygenase	Rattus norvegicus	IC50	=	5000.0	nM	PMID[453626]
NPT570	Individual Protein	Arachidonate 5-lipoxygenase	Homo sapiens	IC50	=	85.0	nM	PMID[453627]
NPT183	Individual Protein	Arachidonate 5-lipoxygenase	Rattus norvegicus	IC50	=	100.0	nM	PMID[453628]
NPT183	Individual Protein	Arachidonate 5-lipoxygenase	Rattus norvegicus	IC50	=	10.0	nM	PMID[453629]
NPT3021	Individual Protein	Arachidonate 5-lipoxygenase	Bos taurus	IC50	=	400.0	nM	PMID[453631]
NPT3021	Individual Protein	Arachidonate 5-lipoxygenase	Bos taurus	IC50	=	1000.0	nM	PMID[453631]
NPT183	Individual Protein	Arachidonate 5-lipoxygenase	Rattus norvegicus	IC50	=	500.0	nM	PMID[453632]
NPT183	Individual Protein	Arachidonate 5-lipoxygenase	Rattus norvegicus	IC50	=	300.0	nM	PMID[453632]
NPT183	Individual Protein	Arachidonate 5-lipoxygenase	Rattus norvegicus	IC50	=	400.0	nM	PMID[453634]
NPT183	Individual Protein	Arachidonate 5-lipoxygenase	Rattus norvegicus	IC50	=	140.0	nM	PMID[453635]
NPT257	Individual Protein	Arachidonate 15-lipoxygenase	Oryctolagus cuniculus	IC50	=	110.0	nM	PMID[453636]
NPT5319	Individual Protein	5-lipoxygenase	Solanum tuberosum	IC50	>	10000.0	nM	PMID[453639]
NPT570	Individual Protein	Arachidonate 5-lipoxygenase	Homo sapiens	IC50	=	130.0	nM	PMID[453642]
NPT1438	Individual Protein	Insulin-like growth factor I receptor	Homo sapiens	IC50	=	900.0	nM	PMID[453645]
NPT83	Cell Line	MCF7	Homo sapiens	IC50	=	24600.0	nM	PMID[453645]
NPT1139	Individual Protein	Arachidonate 15-lipoxygenase, type II	Homo sapiens	IC50	=	11000.0	nM	PMID[453646]
NPT1119	Individual Protein	Arachidonate 12-lipoxygenase	Homo sapiens	IC50	=	2600.0	nM	PMID[453646]
NPT1665	Individual Protein	Cyclooxygenase-1	Bos taurus	Inhibition	=	31.0	%	PMID[453649]
NPT31	Individual Protein	Cyclooxygenase-2	Homo sapiens	Inhibition	=	10.0	%	PMID[453649]
NPT1460	Cell Line	L929	Mus musculus	EC50	=	28000.0	nM	PMID[453650]
NPT1460	Cell Line	L929	Mus musculus	EC50	=	19000.0	nM	PMID[453650]
NPT570	Individual Protein	Arachidonate 5-lipoxygenase	Homo sapiens	IC50	=	500.0	nM	PMID[453653]
NPT1665	Individual Protein	Cyclooxygenase-1	Bos taurus	IC50	=	50000.0	nM	PMID[453654]
NPT31	Individual Protein	Cyclooxygenase-2	Homo sapiens	IC50	>	50000.0	nM	PMID[453654]
NPT570	Individual Protein	Arachidonate 5-lipoxygenase	Homo sapiens	IC50	=	380.0	nM	PMID[453655]
NPT570	Individual Protein	Arachidonate 5-lipoxygenase	Homo sapiens	Inhibition	=	70.0	%	PMID[453656]
NPT1119	Individual Protein	Arachidonate 12-lipoxygenase	Homo sapiens	IC50	=	180.0	nM	PMID[453658]
NPT570	Individual Protein	Arachidonate 5-lipoxygenase	Homo sapiens	IC50	=	35000.0	nM	PMID[453659]
NPT116	Cell Line	HL-60	Homo sapiens	IC50	=	2300.0	nM	PMID[453660]
NPT116	Cell Line	HL-60	Homo sapiens	IC50	=	12200.0	nM	PMID[453660]
NPT1195	Cell Line	PMNL		IC50	=	400.0	nM	PMID[453661]
NPT83	Cell Line	MCF7	Homo sapiens	IC50	=	8500.0	nM	PMID[453665]
NPT139	Cell Line	HT-29	Homo sapiens	IC50	=	51300.0	nM	PMID[453665]
NPT65	Cell Line	HepG2	Homo sapiens	IC50	=	54100.0	nM	PMID[453665]
NPT1083	Cell Line	A-375	Homo sapiens	IC50	=	54300.0	nM	PMID[453665]
NPT1083	Cell Line	A-375	Homo sapiens	Inhibition	=	72.0	%	PMID[453665]
NPT1083	Cell Line	A-375	Homo sapiens	Inhibition	=	74.0	%	PMID[453665]
NPT1083	Cell Line	A-375	Homo sapiens	Inhibition	=	75.0	%	PMID[453665]
NPT1083	Cell Line	A-375	Homo sapiens	IC50	=	230000.0	nM	PMID[453665]
NPT165	Cell Line	HeLa	Homo sapiens	IC50	=	0.08	ug.mL-1	PMID[453670]
NPT441	Individual Protein	Cytochrome P450 19A1	Homo sapiens	IC50	=	11.0	nM	PMID[453674]
NPT1119	Individual Protein	Arachidonate 12-lipoxygenase	Homo sapiens	IC50	=	5900.0	nM	PMID[453675]
NPT570	Individual Protein	Arachidonate 5-lipoxygenase	Homo sapiens	IC50	=	110.0	nM	PMID[453675]
NPT570	Individual Protein	Arachidonate 5-lipoxygenase	Homo sapiens	IC50	=	1500.0	nM	PMID[453679]
NPT984	Cell Line	Hepatocyte		TC50	>	1.0	10'5nM	PMID[453682]
NPT47	Individual Protein	ATP-dependent DNA helicase Q1	Homo sapiens	Potency	=	2238.7	nM	PMID[453684]
NPT47	Individual Protein	ATP-dependent DNA helicase Q1	Homo sapiens	Potency	=	2818.4	nM	PMID[453685]
NPT48	Individual Protein	Lysine-specific demethylase 4D-like	Homo sapiens	Potency	=	22387.2	nM	PMID[453685]
NPT149	Individual Protein	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Homo sapiens	Potency	=	7943.3	nM	PMID[453686]
NPT48	Individual Protein	Lysine-specific demethylase 4D-like	Homo sapiens	Potency	=	35481.3	nM	PMID[453684]
NPT50	Individual Protein	Tyrosyl-DNA phosphodiesterase 1	Homo sapiens	Potency	=	2818.4	nM	PMID[453685]
NPT51	Individual Protein	Microtubule-associated protein tau	Homo sapiens	Potency	=	11220.2	nM	PMID[453685]
NPT51	Individual Protein	Microtubule-associated protein tau	Homo sapiens	Potency	=	15848.9	nM	PMID[453684]
NPT51	Individual Protein	Microtubule-associated protein tau	Homo sapiens	Potency	=	25118.9	nM	PMID[453684]
NPT51	Individual Protein	Microtubule-associated protein tau	Homo sapiens	Potency	=	17782.8	nM	PMID[453685]
NPT5320	Individual Protein	14-3-3 protein gamma	Homo sapiens	IC50	>	50000.0	nM	PMID[453686]
NPT211	Individual Protein	Hypoxia-inducible factor 1 alpha	Homo sapiens	Potency	=	5011.9	nM	PMID[453686]
NPT53	Individual Protein	4'-phosphopantetheinyl transferase ffp	Bacillus subtilis	Potency	=	79432.8	nM	PMID[453685]
NPT53	Individual Protein	4'-phosphopantetheinyl transferase ffp	Bacillus subtilis	Potency	=	39810.7	nM	PMID[453684]
NPT1119	Individual Protein	Arachidonate 12-lipoxygenase	Homo sapiens	Potency	=	14125.4	nM	PMID[453686]
NPT108	Individual Protein	Estrogen receptor alpha	Homo sapiens	IC50	=	22193.67	nM	PMID[453686]
NPT282	Individual Protein	MAP kinase ERK2	Homo sapiens	Potency	=	39810.7	nM	PMID[453686]
NPT55	Individual Protein	Putative fructose-1,6-bisphosphate aldolase	Giardia intestinalis	Potency	=	22334.2	nM	PMID[453685]
NPT55	Individual Protein	Putative fructose-1,6-bisphosphate aldolase	Giardia intestinalis	Potency	=	22334.2	nM	PMID[453684]
NPT151	Individual Protein	15-hydroxyprostaglandin dehydrogenase [NAD+]	Homo sapiens	Potency	=	12589.3	nM	PMID[453684]
NPT151	Individual Protein	15-hydroxyprostaglandin dehydrogenase [NAD+]	Homo sapiens	Potency	=	14125.4	nM	PMID[453685]
NPT539	Individual Protein	Cellular tumor antigen p53	Homo sapiens	Potency	=	31622.8	nM	PMID[453686]
NPT109	Individual Protein	Cytochrome P450 3A4	Homo sapiens	Potency	=	12589.3	nM	PMID[453686]
NPT47	Individual Protein	ATP-dependent DNA helicase Q1	Homo sapiens	Potency	=	44668.4	nM	PMID[453684]
NPT4261	Individual Protein	Lipoxygenase	Glycine max	Activity	=	83.7	%	PMID[453689]
NPT532	Individual Protein	Lysine-specific demethylase 4A	Homo sapiens	Potency	n.a.	22387.2	nM	PMID[453686]
NPT2865	Individual Protein	Glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase	Plasmodium berghei	IC50	=	29200.0	nM	PMID[453686]
NPT4	Individual Protein	Large T antigen	Simian virus 40	IC50	n.a.	21860.0	nM	PMID[453686]
NPT1415	Individual Protein	Heat shock factor protein 1	Mus musculus	EC50	=	2319.0	nM	PMID[453686]
NPT1139	Individual Protein	Arachidonate 15-lipoxygenase, type II	Homo sapiens	Potency	n.a.	1584.9	nM	PMID[453686]
NPT1119	Individual Protein	Arachidonate 12-lipoxygenase	Homo sapiens	IC50	=	110.0	nM	PMID[453697]
NPT198	Individual Protein	Vitamin D receptor	Homo sapiens	Potency	n.a.	44668.4	nM	PMID[453698]
NPT135	Individual Protein	Chromobox protein homolog 1	Homo sapiens	Potency	n.a.	17782.8	nM	PMID[453686]
NPT199	Individual Protein	DNA polymerase kappa	Homo sapiens	Potency	n.a.	794.3	nM	PMID[453700]
NPT199	Individual Protein	DNA polymerase kappa	Homo sapiens	Potency	n.a.	10000.0	nM	PMID[453686]
NPT199	Individual Protein	DNA polymerase kappa	Homo sapiens	Potency	n.a.	22387.2	nM	PMID[453699]
NPT199	Individual Protein	DNA polymerase kappa	Homo sapiens	Potency	n.a.	891.3	nM	PMID[453698]
NPT2865	Individual Protein	Glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase	Plasmodium berghei	IC50	=	68400.0	nM	PMID[453686]
NPT154	Individual Protein	Mothers against decapentaplegic homolog 3	Homo sapiens	Potency	n.a.	3162.3	nM	PMID[453699]
NPT71	Cell Line	HEK293	Homo sapiens	Potency	n.a.	35338.3	nM	PMID[453698]
NPT2865	Individual Protein	Glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase	Plasmodium berghei	IC50	=	54900.0	nM	PMID[453686]
NPT444	Individual Protein	Ubiquitin carboxyl-terminal hydrolase 1	Homo sapiens	Potency	n.a.	10000.0	nM	PMID[453698]
NPT570	Individual Protein	Arachidonate 5-lipoxygenase	Homo sapiens	IC50	=	25.0	nM	PMID[453703]
NPT570	Individual Protein	Arachidonate 5-lipoxygenase	Homo sapiens	IC50	=	120.0	nM	PMID[453704]
NPT3806	Individual Protein	Arachidonate 5-lipoxygenase	Mus musculus	IC50	=	400.0	nM	PMID[453704]
NPT153	Individual Protein	Androgen Receptor	Homo sapiens	IC50	=	38800.0	nM	PMID[453705]
NPT858	Cell Line	LNCaP	Homo sapiens	LD50	>	100.0	uM	PMID[453705]
NPT153	Individual Protein	Androgen Receptor	Homo sapiens	IC50	>	10000.0	nM	PMID[453705]
NPT153	Individual Protein	Androgen Receptor	Homo sapiens	IC50	>	50000.0	nM	PMID[453705]
NPT367	Cell Line	MDA-N	Homo sapiens	GI50	n.a.	10209.39	nM	PMID[453708]
NPT370	Cell Line	NCI-H23	Homo sapiens	GI50	n.a.	20090.93	nM	PMID[453708]
NPT368	Cell Line	SN12C	Homo sapiens	GI50	n.a.	36728.23	nM	PMID[453708]
NPT369	Cell Line	ACHN	Homo sapiens	GI50	n.a.	16143.59	nM	PMID[453708]
NPT371	Cell Line	UO-31	Homo sapiens	GI50	n.a.	9549.93	nM	PMID[453708]
NPT372	Cell Line	HOP-92	Homo sapiens	GI50	n.a.	3140.51	nM	PMID[453708]
NPT116	Cell Line	HL-60	Homo sapiens	GI50	n.a.	2992.26	nM	PMID[453708]
NPT90	Cell Line	DU-145	Homo sapiens	GI50	n.a.	18793.17	nM	PMID[453708]
NPT374	Cell Line	SF-539	Homo sapiens	GI50	n.a.	17538.81	nM	PMID[453708]
NPT373	Cell Line	SK-MEL-5	Homo sapiens	GI50	n.a.	16788.04	nM	PMID[453708]
NPT375	Cell Line	Malme-3M	Homo sapiens	GI50	n.a.	15922.09	nM	PMID[453708]
NPT111	Cell Line	K562	Homo sapiens	GI50	n.a.	25351.29	nM	PMID[453708]
NPT376	Cell Line	A498	Homo sapiens	GI50	n.a.	36982.82	nM	PMID[453708]
NPT377	Cell Line	OVCAR-3	Homo sapiens	GI50	n.a.	13740.42	nM	PMID[453708]
NPT379	Cell Line	HOP-62	Homo sapiens	GI50	n.a.	17100.15	nM	PMID[453708]
NPT112	Cell Line	MOLT-4	Homo sapiens	GI50	n.a.	8222.43	nM	PMID[453708]
NPT378	Cell Line	NCI/ADR-RES	Homo sapiens	GI50	n.a.	22750.97	nM	PMID[453708]
NPT380	Cell Line	U-251	Homo sapiens	GI50	n.a.	18749.95	nM	PMID[453708]
NPT381	Cell Line	OVCAR-8	Homo sapiens	GI50	n.a.	17418.07	nM	PMID[453708]
NPT382	Cell Line	OVCAR-5	Homo sapiens	GI50	n.a.	21232.44	nM	PMID[453708]
NPT445	Individual Protein	Peripheral myelin protein 22	Rattus norvegicus	Potency	n.a.	22370.3	nM	PMID[453698]
NPT383	Cell Line	SNB-19	Homo sapiens	GI50	n.a.	19453.6	nM	PMID[453708]
NPT385	Cell Line	SR	Homo sapiens	GI50	n.a.	9794.9	nM	PMID[453708]
NPT82	Cell Line	MDA-MB-231	Homo sapiens	GI50	n.a.	39084.09	nM	PMID[453708]
NPT384	Cell Line	TK-10	Homo sapiens	GI50	n.a.	23604.78	nM	PMID[453708]
NPT323	Cell Line	SW-620	Homo sapiens	GI50	n.a.	18879.91	nM	PMID[453708]
NPT455	Cell Line	NCI-H522	Homo sapiens	GI50	n.a.	2027.68	nM	PMID[453708]
NPT387	Cell Line	M14	Homo sapiens	GI50	n.a.	16519.62	nM	PMID[453708]
NPT386	Cell Line	KM12	Homo sapiens	GI50	n.a.	17100.15	nM	PMID[453708]
NPT445	Individual Protein	Peripheral myelin protein 22	Rattus norvegicus	Potency	n.a.	8087.5	nM	PMID[453698]
NPT388	Cell Line	NCI-H322M	Homo sapiens	GI50	n.a.	23823.19	nM	PMID[453708]
NPT389	Cell Line	RPMI-8226	Homo sapiens	GI50	n.a.	10069.32	nM	PMID[453708]
NPT456	Cell Line	OVCAR-4	Homo sapiens	GI50	n.a.	14421.15	nM	PMID[453708]
NPT390	Cell Line	LOX IMVI	Homo sapiens	GI50	n.a.	17418.07	nM	PMID[453708]
NPT457	Cell Line	BT-549	Homo sapiens	GI50	n.a.	13899.53	nM	PMID[453708]
NPT147	Cell Line	SK-MEL-2	Homo sapiens	GI50	n.a.	18450.15	nM	PMID[453708]
NPT81	Cell Line	A549	Homo sapiens	GI50	n.a.	33036.95	nM	PMID[453708]
NPT392	Cell Line	SNB-75	Homo sapiens	GI50	n.a.	19815.27	nM	PMID[453708]
NPT391	Cell Line	HCC 2998	Homo sapiens	GI50	n.a.	19054.61	nM	PMID[453708]
NPT148	Cell Line	HCT-15	Homo sapiens	GI50	n.a.	38904.51	nM	PMID[453708]
NPT393	Cell Line	HCT-116	Homo sapiens	GI50	n.a.	17258.38	nM	PMID[453708]
NPT395	Cell Line	SF-268	Homo sapiens	GI50	n.a.	16292.96	nM	PMID[453708]
NPT394	Cell Line	EKVX	Homo sapiens	GI50	n.a.	23442.29	nM	PMID[453708]
NPT83	Cell Line	MCF7	Homo sapiens	GI50	n.a.	20230.19	nM	PMID[453708]
NPT306	Cell Line	PC-3	Homo sapiens	GI50	n.a.	21877.62	nM	PMID[453708]
NPT146	Cell Line	SK-OV-3	Homo sapiens	GI50	n.a.	21478.3	nM	PMID[453708]
NPT396	Cell Line	T47D	Homo sapiens	GI50	n.a.	18365.38	nM	PMID[453708]
NPT398	Cell Line	UACC-62	Homo sapiens	GI50	n.a.	15958.79	nM	PMID[453708]
NPT397	Cell Line	NCI-H460	Homo sapiens	GI50	n.a.	16749.43	nM	PMID[453708]
NPT308	Cell Line	CAKI-1	Homo sapiens	GI50	n.a.	11428.78	nM	PMID[453708]
NPT400	Cell Line	MDA-MB-435	Homo sapiens	GI50	n.a.	13489.63	nM	PMID[453708]
NPT399	Cell Line	SF-295	Homo sapiens	GI50	n.a.	22130.95	nM	PMID[453708]
NPT458	Cell Line	IGROV-1	Homo sapiens	GI50	n.a.	16865.53	nM	PMID[453708]
NPT484	Individual Protein	Luciferin 4-monooxygenase	Photinus pyralis	Potency	n.a.	9074.3	nM	PMID[453698]
NPT402	Cell Line	Hs-578T	Homo sapiens	GI50	n.a.	16865.53	nM	PMID[453708]
NPT401	Cell Line	786-0	Homo sapiens	GI50	n.a.	17179.08	nM	PMID[453708]
NPT404	Cell Line	CCRF-CEM	Homo sapiens	GI50	n.a.	4375.22	nM	PMID[453708]
NPT403	Cell Line	UACC-257	Homo sapiens	GI50	n.a.	18238.96	nM	PMID[453708]
NPT405	Cell Line	NCI-H226	Homo sapiens	GI50	n.a.	22490.55	nM	PMID[453708]
NPT139	Cell Line	HT-29	Homo sapiens	GI50	n.a.	22855.99	nM	PMID[453708]
NPT170	Cell Line	SK-MEL-28	Homo sapiens	GI50	n.a.	16218.1	nM	PMID[453708]
NPT406	Cell Line	RXF 393	Homo sapiens	GI50	n.a.	13583.13	nM	PMID[453708]
NPT407	Cell Line	COLO 205	Homo sapiens	GI50	n.a.	18663.8	nM	PMID[453708]
NPT4261	Individual Protein	Lipoxygenase	Glycine max	Inhibition	=	40.0	%	PMID[453711]
NPT10	Individual Protein	Geminin	Homo sapiens	Potency	n.a.	6513.1	nM	PMID[453686]
NPT1474	Individual Protein	ATP-dependent Clp protease proteolytic subunit	Bacillus subtilis (strain 168)	Potency	n.a.	631.0	nM	PMID[453699]
NPT100	Individual Protein	Glutaminase kidney isoform, mitochondrial	Homo sapiens	Potency	n.a.	12589.3	nM	PMID[453698]
NPT100	Individual Protein	Glutaminase kidney isoform, mitochondrial	Homo sapiens	Potency	n.a.	5623.4	nM	PMID[453686]
NPT10	Individual Protein	Geminin	Homo sapiens	Potency	n.a.	366.3	nM	PMID[453686]
NPT478	Individual Protein	Ataxin-2	Homo sapiens	Potency	n.a.	39810.7	nM	PMID[453686]
NPT1853	Individual Protein	Putative uncharacterized protein	Trypanosoma brucei brucei (strain 927/4 GUTat10.1)	Potency	n.a.	15848.9	nM	PMID[453698]
NPT1853	Individual Protein	Putative uncharacterized protein	Trypanosoma brucei brucei (strain 927/4 GUTat10.1)	Potency	n.a.	44668.4	nM	PMID[453686]
NPT50	Individual Protein	Tyrosyl-DNA phosphodiesterase 1	Homo sapiens	Potency	n.a.	5011.9	nM	PMID[453699]
NPT50	Individual Protein	Tyrosyl-DNA phosphodiesterase 1	Homo sapiens	Potency	n.a.	20596.2	nM	PMID[453686]
NPT50	Individual Protein	Tyrosyl-DNA phosphodiesterase 1	Homo sapiens	Potency	n.a.	1678.9	nM	PMID[453700]
NPT50	Individual Protein	Tyrosyl-DNA phosphodiesterase 1	Homo sapiens	Potency	n.a.	15848.9	nM	PMID[453699]
NPT50	Individual Protein	Tyrosyl-DNA phosphodiesterase 1	Homo sapiens	Potency	n.a.	2985.5	nM	PMID[453700]
NPT160	Individual Protein	TAR DNA-binding protein 43	Homo sapiens	Potency	n.a.	12589.3	nM	PMID[453686]
NPT1139	Individual Protein	Arachidonate 15-lipoxygenase, type II	Homo sapiens	Activity	=	10.0	%	PMID[453720]
NPT1119	Individual Protein	Arachidonate 12-lipoxygenase	Homo sapiens	Activity	=	0.0	%	PMID[453720]
NPT1139	Individual Protein	Arachidonate 15-lipoxygenase, type II	Homo sapiens	Inhibition	=	0.0	%	PMID[453720]
NPT1119	Individual Protein	Arachidonate 12-lipoxygenase	Homo sapiens	Inhibition	=	0.0	%	PMID[453720]
NPT570	Individual Protein	Arachidonate 5-lipoxygenase	Homo sapiens	Inhibition	=	0.0	%	PMID[453720]
NPT1396	Cell Line	NCI-H69	Homo sapiens	IC50	=	4400.0	nM	PMID[453722]
NPT570	Individual Protein	Arachidonate 5-lipoxygenase	Homo sapiens	Inhibition	=	56.6	%	PMID[453723]
NPT2620	Individual Protein	Seed linoleate 9S-lipoxygenase	Glycine max	IC50	=	400000.0	nM	PMID[453724]
NPT2620	Individual Protein	Seed linoleate 9S-lipoxygenase	Glycine max	Inhibition	=	12.7	%	PMID[453724]
NPT535	Individual Protein	Parathyroid hormone receptor	Homo sapiens	Potency	n.a.	28183.8	nM	PMID[453686]
NPT11	Individual Protein	Guanine nucleotide-binding protein G(s), subunit alpha	Homo sapiens	Potency	n.a.	50118.7	nM	PMID[453686]
NPT49	Individual Protein	DNA-(apurinic or apyrimidinic site) lyase	Homo sapiens	Potency	n.a.	31622.8	nM	PMID[453685]
NPT446	Individual Protein	Rap guanine nucleotide exchange factor 3	Homo sapiens	Potency	n.a.	50118.7	nM	PMID[453686]
NPT4261	Individual Protein	Lipoxygenase	Glycine max	IC50	=	51000.0	nM	PMID[453728]
NPT1119	Individual Protein	Arachidonate 12-lipoxygenase	Homo sapiens	Activity	=	1.5	%	PMID[453729]
NPT4261	Individual Protein	Lipoxygenase	Glycine max	IC50	=	9230.0	nM	PMID[453731]
NPT4261	Individual Protein	Lipoxygenase	Glycine max	Inhibition	=	84.0	%	PMID[453732]
NPT4261	Individual Protein	Lipoxygenase	Glycine max	IC50	=	28000.0	nM	PMID[453732]
NPT547	Cell Line	BGC-823	Homo sapiens	IC50	>	60000.0	nM	PMID[453738]
NPT3140	Cell Line	MGC-803	Homo sapiens	IC50	=	45800.0	nM	PMID[453738]
NPT515	Cell Line	SGC-7901	Homo sapiens	IC50	>	60000.0	nM	PMID[453738]
NPT4261	Individual Protein	Lipoxygenase	Glycine max	IC50	=	28000.0	nM	PMID[453740]
NPT1588	Individual Protein	Estradiol 17-beta-dehydrogenase 2	Homo sapiens	IC50	=	380.0	nM	PMID[453741]
NPT1587	Individual Protein	Estradiol 17-beta-dehydrogenase 1	Homo sapiens	IC50	=	5500.0	nM	PMID[453741]
NPT570	Individual Protein	Arachidonate 5-lipoxygenase	Homo sapiens	IC50	=	100.0	nM	PMID[453743]
NPT346	Individual Protein	Transient receptor potential cation channel subfamily A member 1	Homo sapiens	EC50	=	35481.34	nM	PMID[453747]
NPT346	Individual Protein	Transient receptor potential cation channel subfamily A member 1	Homo sapiens	EC50	=	35000.0	nM	PMID[453747]
NPT346	Individual Protein	Transient receptor potential cation channel subfamily A member 1	Homo sapiens	EC50	=	4900.0	nM	PMID[453747]
NPT1139	Individual Protein	Arachidonate 15-lipoxygenase, type II	Homo sapiens	IC50	=	13600.0	nM	PMID[453750]
NPT1139	Individual Protein	Arachidonate 15-lipoxygenase, type II	Homo sapiens	Activity	=	31.4	%	PMID[453750]
NPT4261	Individual Protein	Lipoxygenase	Glycine max	IC50	=	500.0	nM	PMID[453751]
NPT4909	Cell Line	Fibroblasts		Multiplex	=	63.0	%	PMID[453758]
NPT4909	Cell Line	Fibroblasts		Multiplex	=	22.0	%	PMID[453758]
NPT4909	Cell Line	Fibroblasts		Multiplex	=	1.0	%	PMID[453758]
NPT4909	Cell Line	Fibroblasts		Multiplex	=	44.0	%	PMID[453758]
NPT4909	Cell Line	Fibroblasts		Multiplex	=	27.0	%	PMID[453758]
NPT4909	Cell Line	Fibroblasts		Multiplex	=	7.0	%	PMID[453758]
NPT4909	Cell Line	Fibroblasts		Multiplex	=	36.0	%	PMID[453758]
NPT4909	Cell Line	Fibroblasts		Multiplex	=	33.0	%	PMID[453758]
NPT4909	Cell Line	Fibroblasts		Multiplex	=	107.0	%	PMID[453758]
NPT4909	Cell Line	Fibroblasts		Multiplex	=	31.0	%	PMID[453758]
NPT4909	Cell Line	Fibroblasts		Multiplex	=	87.0	%	PMID[453758]
NPT4909	Cell Line	Fibroblasts		Multiplex	=	19.0	%	PMID[453758]
NPT4909	Cell Line	Fibroblasts		Multiplex	=	46.0	%	PMID[453758]
NPT4909	Cell Line	Fibroblasts		Multiplex	=	14.0	%	PMID[453758]
NPT4909	Cell Line	Fibroblasts		Multiplex	=	18.0	%	PMID[453758]
NPT4909	Cell Line	Fibroblasts		Multiplex	=	6.0	%	PMID[453758]
NPT4909	Cell Line	Fibroblasts		Multiplex	=	12.0	%	PMID[453758]
NPT4909	Cell Line	Fibroblasts		Multiplex	=	85.0	%	PMID[453758]
NPT4909	Cell Line	Fibroblasts		Multiplex	=	13.0	%	PMID[453758]
NPT4909	Cell Line	Fibroblasts		Multiplex	=	108.0	n.a.	PMID[453758]
NPT4909	Cell Line	Fibroblasts		Multiplex	=	66.0	%	PMID[453758]
NPT4909	Cell Line	Fibroblasts		Multiplex	=	32.0	%	PMID[453758]
NPT4909	Cell Line	Fibroblasts		Multiplex	=	0.0	%	PMID[453758]
NPT4909	Cell Line	Fibroblasts		Multiplex	=	8.0	%	PMID[453758]
NPT4909	Cell Line	Fibroblasts		Multiplex	=	23.0	%	PMID[453758]
NPT4909	Cell Line	Fibroblasts		Multiplex	=	125.0	%	PMID[453758]
NPT4909	Cell Line	Fibroblasts		Multiplex	=	20.0	%	PMID[453758]
NPT4909	Cell Line	Fibroblasts		Multiplex	=	35.0	%	PMID[453758]
NPT4909	Cell Line	Fibroblasts		Multiplex	=	10.0	%	PMID[453758]
NPT4909	Cell Line	Fibroblasts		Multiplex	=	89.0	%	PMID[453758]
NPT4909	Cell Line	Fibroblasts		Multiplex	=	212.0	n.a.	PMID[453758]
NPT2615	Cell Line	HEK-293T	Homo sapiens	Multiplex	=	12.0	%	PMID[453758]
NPT2615	Cell Line	HEK-293T	Homo sapiens	Multiplex	=	5.0	%	PMID[453758]
NPT2615	Cell Line	HEK-293T	Homo sapiens	Multiplex	=	1.0	%	PMID[453758]
NPT2615	Cell Line	HEK-293T	Homo sapiens	Multiplex	=	65.0	%	PMID[453758]
NPT2615	Cell Line	HEK-293T	Homo sapiens	Multiplex	=	9.0	%	PMID[453758]
NPT2615	Cell Line	HEK-293T	Homo sapiens	Multiplex	=	11.0	%	PMID[453758]
NPT2615	Cell Line	HEK-293T	Homo sapiens	Multiplex	=	87.0	%	PMID[453758]
NPT2615	Cell Line	HEK-293T	Homo sapiens	Multiplex	=	29.0	%	PMID[453758]
NPT2615	Cell Line	HEK-293T	Homo sapiens	Multiplex	=	322.0	%	PMID[453758]
NPT2615	Cell Line	HEK-293T	Homo sapiens	Multiplex	=	27.0	%	PMID[453758]
NPT2615	Cell Line	HEK-293T	Homo sapiens	Multiplex	=	18.0	%	PMID[453758]
NPT2615	Cell Line	HEK-293T	Homo sapiens	Multiplex	=	48.0	%	PMID[453758]
NPT2615	Cell Line	HEK-293T	Homo sapiens	Multiplex	=	3.0	%	PMID[453758]
NPT2615	Cell Line	HEK-293T	Homo sapiens	Multiplex	=	6.0	%	PMID[453758]
NPT2615	Cell Line	HEK-293T	Homo sapiens	Multiplex	=	81.0	%	PMID[453758]
NPT2615	Cell Line	HEK-293T	Homo sapiens	Multiplex	=	96.0	%	PMID[453758]
NPT2615	Cell Line	HEK-293T	Homo sapiens	Multiplex	=	46.0	%	PMID[453758]
NPT2615	Cell Line	HEK-293T	Homo sapiens	Multiplex	=	212.0	n.a.	PMID[453758]
NPT4909	Cell Line	Fibroblasts		Multiplex	=	60.0	%	PMID[453758]
NPT4909	Cell Line	Fibroblasts		Multiplex	=	30.0	%	PMID[453758]
NPT4909	Cell Line	Fibroblasts		Multiplex	=	5.0	%	PMID[453758]
NPT4909	Cell Line	Fibroblasts		Multiplex	=	39.0	%	PMID[453758]
NPT4909	Cell Line	Fibroblasts		Multiplex	=	91.0	%	PMID[453758]
NPT4909	Cell Line	Fibroblasts		Multiplex	=	37.0	%	PMID[453758]
NPT4909	Cell Line	Fibroblasts		Multiplex	=	34.0	%	PMID[453758]
NPT4909	Cell Line	Fibroblasts		Multiplex	=	125.0	n.a.	PMID[453758]
NPT2615	Cell Line	HEK-293T	Homo sapiens	Multiplex	=	45.0	%	PMID[453758]
NPT2615	Cell Line	HEK-293T	Homo sapiens	Multiplex	=	7.0	%	PMID[453758]
NPT2615	Cell Line	HEK-293T	Homo sapiens	Multiplex	=	13.0	%	PMID[453758]
NPT2615	Cell Line	HEK-293T	Homo sapiens	Multiplex	=	88.0	%	PMID[453758]
NPT2615	Cell Line	HEK-293T	Homo sapiens	Multiplex	=	256.0	%	PMID[453758]
NPT2615	Cell Line	HEK-293T	Homo sapiens	Multiplex	=	8.0	%	PMID[453758]
NPT2615	Cell Line	HEK-293T	Homo sapiens	Multiplex	=	36.0	%	PMID[453758]
NPT2615	Cell Line	HEK-293T	Homo sapiens	Multiplex	=	2.0	%	PMID[453758]
NPT2615	Cell Line	HEK-293T	Homo sapiens	Multiplex	=	28.0	%	PMID[453758]
NPT2615	Cell Line	HEK-293T	Homo sapiens	Multiplex	=	91.0	%	PMID[453758]
NPT2615	Cell Line	HEK-293T	Homo sapiens	Multiplex	=	94.0	%	PMID[453758]
NPT2615	Cell Line	HEK-293T	Homo sapiens	Multiplex	=	57.0	%	PMID[453758]
NPT2615	Cell Line	HEK-293T	Homo sapiens	Multiplex	=	194.0	n.a.	PMID[453758]
NPT2615	Cell Line	HEK-293T	Homo sapiens	Multiplex	=	42.0	%	PMID[453758]
NPT2615	Cell Line	HEK-293T	Homo sapiens	Multiplex	=	14.0	%	PMID[453758]
NPT2615	Cell Line	HEK-293T	Homo sapiens	Multiplex	=	39.0	%	PMID[453758]
NPT2615	Cell Line	HEK-293T	Homo sapiens	Multiplex	=	4.0	%	PMID[453758]
NPT2615	Cell Line	HEK-293T	Homo sapiens	Multiplex	=	51.0	%	PMID[453758]
NPT2615	Cell Line	HEK-293T	Homo sapiens	Multiplex	=	293.0	%	PMID[453758]
NPT2615	Cell Line	HEK-293T	Homo sapiens	Multiplex	=	31.0	%	PMID[453758]
NPT2615	Cell Line	HEK-293T	Homo sapiens	Multiplex	=	35.0	%	PMID[453758]
NPT2615	Cell Line	HEK-293T	Homo sapiens	Multiplex	=	64.0	%	PMID[453758]
NPT2615	Cell Line	HEK-293T	Homo sapiens	Multiplex	=	15.0	%	PMID[453758]
NPT2615	Cell Line	HEK-293T	Homo sapiens	Multiplex	=	156.0	n.a.	PMID[453758]
NPT2615	Cell Line	HEK-293T	Homo sapiens	Multiplex	=	0.0	%	PMID[453758]
NPT2615	Cell Line	HEK-293T	Homo sapiens	Multiplex	=	24.0	%	PMID[453758]
NPT2615	Cell Line	HEK-293T	Homo sapiens	Multiplex	=	17.0	%	PMID[453758]
NPT2615	Cell Line	HEK-293T	Homo sapiens	Multiplex	=	90.0	%	PMID[453758]
NPT2615	Cell Line	HEK-293T	Homo sapiens	Multiplex	=	67.0	%	PMID[453758]
NPT2615	Cell Line	HEK-293T	Homo sapiens	Multiplex	=	233.0	%	PMID[453758]
NPT2615	Cell Line	HEK-293T	Homo sapiens	Multiplex	=	20.0	%	PMID[453758]
NPT2615	Cell Line	HEK-293T	Homo sapiens	Multiplex	=	95.0	%	PMID[453758]
NPT2615	Cell Line	HEK-293T	Homo sapiens	Multiplex	=	236.0	n.a.	PMID[453758]
NPT2615	Cell Line	HEK-293T	Homo sapiens	Multiplex	=	16.0	%	PMID[453758]
NPT2615	Cell Line	HEK-293T	Homo sapiens	Multiplex	=	77.0	%	PMID[453758]
NPT2615	Cell Line	HEK-293T	Homo sapiens	Multiplex	=	178.0	n.a.	PMID[453758]
NPT2615	Cell Line	HEK-293T	Homo sapiens	Multiplex	=	33.0	%	PMID[453758]
NPT2615	Cell Line	HEK-293T	Homo sapiens	Multiplex	=	21.0	%	PMID[453758]
NPT2615	Cell Line	HEK-293T	Homo sapiens	Multiplex	=	66.0	%	PMID[453758]
NPT2615	Cell Line	HEK-293T	Homo sapiens	Multiplex	=	69.0	%	PMID[453758]
NPT2615	Cell Line	HEK-293T	Homo sapiens	Multiplex	=	41.0	%	PMID[453758]
NPT2615	Cell Line	HEK-293T	Homo sapiens	Multiplex	=	83.0	%	PMID[453758]
NPT2615	Cell Line	HEK-293T	Homo sapiens	Multiplex	=	58.0	%	PMID[453758]
NPT2615	Cell Line	HEK-293T	Homo sapiens	Multiplex	=	82.0	%	PMID[453758]
NPT2615	Cell Line	HEK-293T	Homo sapiens	Multiplex	=	72.0	%	PMID[453758]
NPT2615	Cell Line	HEK-293T	Homo sapiens	Multiplex	=	175.0	n.a.	PMID[453758]
NPT2615	Cell Line	HEK-293T	Homo sapiens	Multiplex	=	37.0	%	PMID[453758]
NPT2615	Cell Line	HEK-293T	Homo sapiens	Multiplex	=	68.0	%	PMID[453758]
NPT2615	Cell Line	HEK-293T	Homo sapiens	Multiplex	=	49.0	%	PMID[453758]
NPT2615	Cell Line	HEK-293T	Homo sapiens	Multiplex	=	274.0	%	PMID[453758]
NPT2615	Cell Line	HEK-293T	Homo sapiens	Multiplex	=	32.0	%	PMID[453758]
NPT2615	Cell Line	HEK-293T	Homo sapiens	Multiplex	=	71.0	%	PMID[453758]
NPT2615	Cell Line	HEK-293T	Homo sapiens	Multiplex	=	84.0	%	PMID[453758]
NPT2615	Cell Line	HEK-293T	Homo sapiens	Multiplex	=	211.0	n.a.	PMID[453758]
NPT2615	Cell Line	HEK-293T	Homo sapiens	Multiplex	=	34.0	%	PMID[453758]
NPT2615	Cell Line	HEK-293T	Homo sapiens	Multiplex	=	52.0	%	PMID[453758]
NPT2615	Cell Line	HEK-293T	Homo sapiens	Multiplex	=	150.0	n.a.	PMID[453758]
NPT2615	Cell Line	HEK-293T	Homo sapiens	Multiplex	=	19.0	%	PMID[453758]
NPT2615	Cell Line	HEK-293T	Homo sapiens	Multiplex	=	22.0	%	PMID[453758]
NPT2615	Cell Line	HEK-293T	Homo sapiens	Multiplex	=	73.0	%	PMID[453758]
NPT2615	Cell Line	HEK-293T	Homo sapiens	Multiplex	=	50.0	%	PMID[453758]
NPT2615	Cell Line	HEK-293T	Homo sapiens	Multiplex	=	92.0	%	PMID[453758]
NPT2615	Cell Line	HEK-293T	Homo sapiens	Multiplex	=	192.0	n.a.	PMID[453758]
NPT1045	Cell Line	U2OS	Homo sapiens	Multiplex	=	31.0	%	PMID[453758]
NPT1045	Cell Line	U2OS	Homo sapiens	Multiplex	=	8.0	%	PMID[453758]
NPT1045	Cell Line	U2OS	Homo sapiens	Multiplex	=	0.0	%	PMID[453758]
NPT1045	Cell Line	U2OS	Homo sapiens	Multiplex	=	82.0	%	PMID[453758]
NPT1045	Cell Line	U2OS	Homo sapiens	Multiplex	=	5.0	%	PMID[453758]
NPT1045	Cell Line	U2OS	Homo sapiens	Multiplex	=	7.0	%	PMID[453758]
NPT1045	Cell Line	U2OS	Homo sapiens	Multiplex	=	68.0	%	PMID[453758]
NPT1045	Cell Line	U2OS	Homo sapiens	Multiplex	=	212.0	%	PMID[453758]
NPT1045	Cell Line	U2OS	Homo sapiens	Multiplex	=	9.0	%	PMID[453758]
NPT1045	Cell Line	U2OS	Homo sapiens	Multiplex	=	61.0	%	PMID[453758]
NPT1045	Cell Line	U2OS	Homo sapiens	Multiplex	=	18.0	%	PMID[453758]
NPT1045	Cell Line	U2OS	Homo sapiens	Multiplex	=	14.0	%	PMID[453758]
NPT1045	Cell Line	U2OS	Homo sapiens	Multiplex	=	10.0	%	PMID[453758]
NPT1045	Cell Line	U2OS	Homo sapiens	Multiplex	=	15.0	%	PMID[453758]
NPT1045	Cell Line	U2OS	Homo sapiens	Multiplex	=	38.0	%	PMID[453758]
NPT1045	Cell Line	U2OS	Homo sapiens	Multiplex	=	85.0	%	PMID[453758]
NPT1045	Cell Line	U2OS	Homo sapiens	Multiplex	=	12.0	%	PMID[453758]
NPT1045	Cell Line	U2OS	Homo sapiens	Multiplex	=	59.0	%	PMID[453758]
NPT1045	Cell Line	U2OS	Homo sapiens	Multiplex	=	139.0	n.a.	PMID[453758]
NPT1045	Cell Line	U2OS	Homo sapiens	Multiplex	=	35.0	%	PMID[453758]
NPT1045	Cell Line	U2OS	Homo sapiens	Multiplex	=	1.0	%	PMID[453758]
NPT1045	Cell Line	U2OS	Homo sapiens	Multiplex	=	88.0	%	PMID[453758]
NPT1045	Cell Line	U2OS	Homo sapiens	Multiplex	=	2.0	%	PMID[453758]
NPT1045	Cell Line	U2OS	Homo sapiens	Multiplex	=	64.0	%	PMID[453758]
NPT1045	Cell Line	U2OS	Homo sapiens	Multiplex	=	6.0	%	PMID[453758]
NPT1045	Cell Line	U2OS	Homo sapiens	Multiplex	=	330.0	%	PMID[453758]
NPT1045	Cell Line	U2OS	Homo sapiens	Multiplex	=	72.0	%	PMID[453758]
NPT1045	Cell Line	U2OS	Homo sapiens	Multiplex	=	74.0	%	PMID[453758]
NPT1045	Cell Line	U2OS	Homo sapiens	Multiplex	=	27.0	%	PMID[453758]
NPT1045	Cell Line	U2OS	Homo sapiens	Multiplex	=	90.0	%	PMID[453758]
NPT1045	Cell Line	U2OS	Homo sapiens	Multiplex	=	76.0	%	PMID[453758]
NPT1045	Cell Line	U2OS	Homo sapiens	Multiplex	=	185.0	n.a.	PMID[453758]
NPT1045	Cell Line	U2OS	Homo sapiens	Multiplex	=	43.0	%	PMID[453758]
NPT1045	Cell Line	U2OS	Homo sapiens	Multiplex	=	86.0	%	PMID[453758]
NPT1045	Cell Line	U2OS	Homo sapiens	Multiplex	=	4.0	%	PMID[453758]
NPT1045	Cell Line	U2OS	Homo sapiens	Multiplex	=	11.0	%	PMID[453758]
NPT1045	Cell Line	U2OS	Homo sapiens	Multiplex	=	56.0	%	PMID[453758]
NPT1045	Cell Line	U2OS	Homo sapiens	Multiplex	=	153.0	%	PMID[453758]
NPT1045	Cell Line	U2OS	Homo sapiens	Multiplex	=	19.0	%	PMID[453758]
NPT1045	Cell Line	U2OS	Homo sapiens	Multiplex	=	66.0	%	PMID[453758]
NPT1045	Cell Line	U2OS	Homo sapiens	Multiplex	=	92.0	%	PMID[453758]
NPT1045	Cell Line	U2OS	Homo sapiens	Multiplex	=	16.0	%	PMID[453758]
NPT1045	Cell Line	U2OS	Homo sapiens	Multiplex	=	33.0	%	PMID[453758]
NPT1045	Cell Line	U2OS	Homo sapiens	Multiplex	=	93.0	%	PMID[453758]
NPT1045	Cell Line	U2OS	Homo sapiens	Multiplex	=	77.0	%	PMID[453758]
NPT1045	Cell Line	U2OS	Homo sapiens	Multiplex	=	105.0	n.a.	PMID[453758]
NPT1045	Cell Line	U2OS	Homo sapiens	Multiplex	=	52.0	%	PMID[453758]
NPT1045	Cell Line	U2OS	Homo sapiens	Multiplex	=	83.0	%	PMID[453758]
NPT1045	Cell Line	U2OS	Homo sapiens	Multiplex	=	3.0	%	PMID[453758]
NPT1045	Cell Line	U2OS	Homo sapiens	Multiplex	=	47.0	%	PMID[453758]
NPT1045	Cell Line	U2OS	Homo sapiens	Multiplex	=	102.0	%	PMID[453758]
NPT1045	Cell Line	U2OS	Homo sapiens	Multiplex	=	94.0	%	PMID[453758]
NPT1045	Cell Line	U2OS	Homo sapiens	Multiplex	=	77.0	n.a.	PMID[453758]
NPT4909	Cell Line	Fibroblasts		Multiplex	=	52.0	%	PMID[453758]
NPT4909	Cell Line	Fibroblasts		Multiplex	=	9.0	%	PMID[453758]
NPT4909	Cell Line	Fibroblasts		Multiplex	=	83.0	%	PMID[453758]
NPT4909	Cell Line	Fibroblasts		Multiplex	=	3.0	%	PMID[453758]
NPT4909	Cell Line	Fibroblasts		Multiplex	=	47.0	%	PMID[453758]
NPT4909	Cell Line	Fibroblasts		Multiplex	=	108.0	%	PMID[453758]
NPT4909	Cell Line	Fibroblasts		Multiplex	=	16.0	%	PMID[453758]
NPT4909	Cell Line	Fibroblasts		Multiplex	=	2.0	%	PMID[453758]
NPT4909	Cell Line	Fibroblasts		Multiplex	=	90.0	%	PMID[453758]
NPT4909	Cell Line	Fibroblasts		Multiplex	=	94.0	%	PMID[453758]
NPT4909	Cell Line	Fibroblasts		Multiplex	=	61.0	%	PMID[453758]
NPT4909	Cell Line	Fibroblasts		Multiplex	=	77.0	n.a.	PMID[453758]
NPT4909	Cell Line	Fibroblasts		Multiplex	=	53.0	%	PMID[453758]
NPT4909	Cell Line	Fibroblasts		Multiplex	=	51.0	%	PMID[453758]
NPT4909	Cell Line	Fibroblasts		Multiplex	=	110.0	%	PMID[453758]
NPT4909	Cell Line	Fibroblasts		Multiplex	=	29.0	%	PMID[453758]
NPT4909	Cell Line	Fibroblasts		Multiplex	=	75.0	%	PMID[453758]
NPT4909	Cell Line	Fibroblasts		Multiplex	=	25.0	%	PMID[453758]
NPT4909	Cell Line	Fibroblasts		Multiplex	=	40.0	%	PMID[453758]
NPT4909	Cell Line	Fibroblasts		Multiplex	=	162.0	n.a.	PMID[453758]
NPT4909	Cell Line	Fibroblasts		Multiplex	=	49.0	%	PMID[453758]
NPT4909	Cell Line	Fibroblasts		Multiplex	=	21.0	%	PMID[453758]
NPT4909	Cell Line	Fibroblasts		Multiplex	=	50.0	%	PMID[453758]
NPT4909	Cell Line	Fibroblasts		Multiplex	=	106.0	%	PMID[453758]
NPT4909	Cell Line	Fibroblasts		Multiplex	=	93.0	%	PMID[453758]
NPT4909	Cell Line	Fibroblasts		Multiplex	=	165.0	n.a.	PMID[453758]
NPT4909	Cell Line	Fibroblasts		Multiplex	=	4.0	%	PMID[453758]
NPT4909	Cell Line	Fibroblasts		Multiplex	=	170.0	n.a.	PMID[453758]
NPT4909	Cell Line	Fibroblasts		Multiplex	=	15.0	%	PMID[453758]
NPT4909	Cell Line	Fibroblasts		Multiplex	=	70.0	%	PMID[453758]
NPT4909	Cell Line	Fibroblasts		Multiplex	=	17.0	%	PMID[453758]
NPT4909	Cell Line	Fibroblasts		Multiplex	=	80.0	%	PMID[453758]
NPT4909	Cell Line	Fibroblasts		Multiplex	=	90.0	n.a.	PMID[453758]
NPT1045	Cell Line	U2OS	Homo sapiens	Multiplex	=	13.0	%	PMID[453758]
NPT1045	Cell Line	U2OS	Homo sapiens	Multiplex	=	70.0	%	PMID[453758]
NPT1045	Cell Line	U2OS	Homo sapiens	Multiplex	=	26.0	%	PMID[453758]
NPT1045	Cell Line	U2OS	Homo sapiens	Multiplex	=	152.0	%	PMID[453758]
NPT1045	Cell Line	U2OS	Homo sapiens	Multiplex	=	17.0	%	PMID[453758]
NPT1045	Cell Line	U2OS	Homo sapiens	Multiplex	=	60.0	%	PMID[453758]
NPT1045	Cell Line	U2OS	Homo sapiens	Multiplex	=	49.0	%	PMID[453758]
NPT1045	Cell Line	U2OS	Homo sapiens	Multiplex	=	84.0	%	PMID[453758]
NPT1045	Cell Line	U2OS	Homo sapiens	Multiplex	=	21.0	%	PMID[453758]
NPT1045	Cell Line	U2OS	Homo sapiens	Multiplex	=	101.0	n.a.	PMID[453758]
NPT4909	Cell Line	Fibroblasts		Multiplex	=	100.0	%	PMID[453758]
NPT4909	Cell Line	Fibroblasts		Multiplex	=	77.0	%	PMID[453758]
NPT4909	Cell Line	Fibroblasts		Multiplex	=	11.0	%	PMID[453758]
NPT4909	Cell Line	Fibroblasts		Multiplex	=	88.0	%	PMID[453758]
NPT4909	Cell Line	Fibroblasts		Multiplex	=	118.0	n.a.	PMID[453758]
NPT4909	Cell Line	Fibroblasts		Multiplex	=	62.0	%	PMID[453758]
NPT4909	Cell Line	Fibroblasts		Multiplex	=	82.0	%	PMID[453758]
NPT4909	Cell Line	Fibroblasts		Multiplex	=	101.0	n.a.	PMID[453758]
NPT1045	Cell Line	U2OS	Homo sapiens	Multiplex	=	37.0	%	PMID[453758]
NPT1045	Cell Line	U2OS	Homo sapiens	Multiplex	=	78.0	%	PMID[453758]
NPT1045	Cell Line	U2OS	Homo sapiens	Multiplex	=	62.0	%	PMID[453758]
NPT1045	Cell Line	U2OS	Homo sapiens	Multiplex	=	165.0	%	PMID[453758]
NPT1045	Cell Line	U2OS	Homo sapiens	Multiplex	=	30.0	%	PMID[453758]
NPT1045	Cell Line	U2OS	Homo sapiens	Multiplex	=	118.0	n.a.	PMID[453758]
NPT2615	Cell Line	HEK-293T	Homo sapiens	Multiplex	=	10.0	%	PMID[453758]
NPT2615	Cell Line	HEK-293T	Homo sapiens	Multiplex	=	594.0	%	PMID[453758]
NPT2615	Cell Line	HEK-293T	Homo sapiens	Multiplex	=	23.0	%	PMID[453758]
NPT2615	Cell Line	HEK-293T	Homo sapiens	Multiplex	=	85.0	%	PMID[453758]
NPT2615	Cell Line	HEK-293T	Homo sapiens	Multiplex	=	312.0	n.a.	PMID[453758]
NPT2615	Cell Line	HEK-293T	Homo sapiens	Multiplex	=	60.0	%	PMID[453758]
NPT2615	Cell Line	HEK-293T	Homo sapiens	Multiplex	=	351.0	%	PMID[453758]
NPT2615	Cell Line	HEK-293T	Homo sapiens	Multiplex	=	26.0	%	PMID[453758]
NPT2615	Cell Line	HEK-293T	Homo sapiens	Multiplex	=	78.0	%	PMID[453758]
NPT2615	Cell Line	HEK-293T	Homo sapiens	Multiplex	=	187.0	n.a.	PMID[453758]
NPT4909	Cell Line	Fibroblasts		Multiplex	=	92.0	%	PMID[453758]
NPT4909	Cell Line	Fibroblasts		Multiplex	=	84.0	%	PMID[453758]
NPT4909	Cell Line	Fibroblasts		Multiplex	=	109.0	n.a.	PMID[453758]
NPT2615	Cell Line	HEK-293T	Homo sapiens	Multiplex	=	25.0	%	PMID[453758]
NPT2615	Cell Line	HEK-293T	Homo sapiens	Multiplex	=	280.0	n.a.	PMID[453758]
NPT2615	Cell Line	HEK-293T	Homo sapiens	Multiplex	=	223.0	n.a.	PMID[453758]
NPT1045	Cell Line	U2OS	Homo sapiens	Multiplex	=	45.0	%	PMID[453758]
NPT1045	Cell Line	U2OS	Homo sapiens	Multiplex	=	54.0	%	PMID[453758]
NPT1045	Cell Line	U2OS	Homo sapiens	Multiplex	=	206.0	n.a.	PMID[453758]
NPT1045	Cell Line	U2OS	Homo sapiens	Multiplex	=	20.0	%	PMID[453758]
NPT1045	Cell Line	U2OS	Homo sapiens	Multiplex	=	80.0	%	PMID[453758]
NPT1045	Cell Line	U2OS	Homo sapiens	Multiplex	=	69.0	n.a.	PMID[453758]
NPT1045	Cell Line	U2OS	Homo sapiens	Multiplex	=	75.0	%	PMID[453758]
NPT1045	Cell Line	U2OS	Homo sapiens	Multiplex	=	91.0	%	PMID[453758]
NPT1045	Cell Line	U2OS	Homo sapiens	Multiplex	=	164.0	n.a.	PMID[453758]
NPT1045	Cell Line	U2OS	Homo sapiens	Multiplex	=	81.0	%	PMID[453758]
NPT1045	Cell Line	U2OS	Homo sapiens	Multiplex	=	73.0	%	PMID[453758]
NPT1045	Cell Line	U2OS	Homo sapiens	Multiplex	=	25.0	%	PMID[453758]
NPT1045	Cell Line	U2OS	Homo sapiens	Multiplex	=	87.0	%	PMID[453758]
NPT1045	Cell Line	U2OS	Homo sapiens	Multiplex	=	61.0	n.a.	PMID[453758]
NPT4909	Cell Line	Fibroblasts		Multiplex	=	68.0	%	PMID[453758]
NPT4909	Cell Line	Fibroblasts		Multiplex	=	24.0	%	PMID[453758]
NPT4909	Cell Line	Fibroblasts		Multiplex	=	64.0	%	PMID[453758]
NPT4909	Cell Line	Fibroblasts		Multiplex	=	101.0	%	PMID[453758]
NPT4909	Cell Line	Fibroblasts		Multiplex	=	55.0	%	PMID[453758]
NPT4909	Cell Line	Fibroblasts		Multiplex	=	45.0	%	PMID[453758]
NPT4909	Cell Line	Fibroblasts		Multiplex	=	110.0	n.a.	PMID[453758]
NPT1045	Cell Line	U2OS	Homo sapiens	Multiplex	=	69.0	%	PMID[453758]
NPT1045	Cell Line	U2OS	Homo sapiens	Multiplex	=	22.0	%	PMID[453758]
NPT1045	Cell Line	U2OS	Homo sapiens	Multiplex	=	95.0	%	PMID[453758]
NPT1045	Cell Line	U2OS	Homo sapiens	Multiplex	=	161.0	n.a.	PMID[453758]
NPT1045	Cell Line	U2OS	Homo sapiens	Multiplex	=	50.0	%	PMID[453758]
NPT1045	Cell Line	U2OS	Homo sapiens	Multiplex	=	100.0	%	PMID[453758]
NPT1045	Cell Line	U2OS	Homo sapiens	Multiplex	=	70.0	n.a.	PMID[453758]
NPT4909	Cell Line	Fibroblasts		Multiplex	=	38.0	%	PMID[453758]
NPT4909	Cell Line	Fibroblasts		Multiplex	=	70.0	n.a.	PMID[453758]
NPT1045	Cell Line	U2OS	Homo sapiens	Multiplex	=	97.0	%	PMID[453758]
NPT1045	Cell Line	U2OS	Homo sapiens	Multiplex	=	310.0	n.a.	PMID[453758]
NPT2615	Cell Line	HEK-293T	Homo sapiens	Multiplex	=	55.0	%	PMID[453758]
NPT2615	Cell Line	HEK-293T	Homo sapiens	Multiplex	=	38.0	%	PMID[453758]
NPT2615	Cell Line	HEK-293T	Homo sapiens	Multiplex	=	254.0	n.a.	PMID[453758]
NPT2615	Cell Line	HEK-293T	Homo sapiens	Multiplex	=	255.0	n.a.	PMID[453758]
NPT4909	Cell Line	Fibroblasts		Multiplex	=	75.0	n.a.	PMID[453758]
NPT1045	Cell Line	U2OS	Homo sapiens	Multiplex	=	85.0	n.a.	PMID[453758]
NPT1045	Cell Line	U2OS	Homo sapiens	Multiplex	=	23.0	%	PMID[453758]
NPT1045	Cell Line	U2OS	Homo sapiens	Multiplex	=	53.0	n.a.	PMID[453758]
NPT4909	Cell Line	Fibroblasts		Multiplex	=	53.0	n.a.	PMID[453758]
NPT1045	Cell Line	U2OS	Homo sapiens	Multiplex	=	42.0	n.a.	PMID[453758]
NPT4909	Cell Line	Fibroblasts		Multiplex	=	42.0	n.a.	PMID[453758]
NPT2615	Cell Line	HEK-293T	Homo sapiens	Cell Viability	=	1.0	n.a.	PMID[453758]
NPT2615	Cell Line	HEK-293T	Homo sapiens	Cell Viability	=	0.0	n.a.	PMID[453758]
NPT1045	Cell Line	U2OS	Homo sapiens	Cell Viability	=	0.0	n.a.	PMID[453758]
NPT1045	Cell Line	U2OS	Homo sapiens	Cell Viability	=	6.0	n.a.	PMID[453758]
NPT4909	Cell Line	Fibroblasts		Cell Viability	=	0.0	n.a.	PMID[453758]
NPT4909	Cell Line	Fibroblasts		Cell Viability	=	2.0	n.a.	PMID[453758]
NPT1045	Cell Line	U2OS	Homo sapiens	Cell Viability	=	5.0	n.a.	PMID[453758]
NPT570	Individual Protein	Arachidonate 5-lipoxygenase	Homo sapiens	IC50	=	97.0	nM	PMID[453760]
NPT153	Individual Protein	Androgen Receptor	Homo sapiens	Potency	n.a.	38895.2	nM	PubChem BioAssay data set
NPT152	Individual Protein	Nuclear factor erythroid 2-related factor 2	Homo sapiens	Potency	n.a.	30637.9	nM	PubChem BioAssay data set
NPT162	Individual Protein	Heat shock protein beta-1	Homo sapiens	Potency	n.a.	24541.2	nM	PubChem BioAssay data set
NPT106	Individual Protein	Peroxisome proliferator-activated receptor delta	Homo sapiens	Potency	n.a.	21872.4	nM	PubChem BioAssay data set
NPT163	Individual Protein	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens	Potency	n.a.	54941	nM	PubChem BioAssay data set
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	3.1	mg ear-1	PMID[453616]
NPT792	Individual Protein	Arachidonate 15-lipoxygenase	Homo sapiens	IC50	=	4900.0	nM	PMID[453617]
NPT605	Organism	Homo sapiens	Homo sapiens	IC50	=	300.0	nM	PMID[453618]
NPT1559	Protein Family	Cyclooxygenase	Rattus norvegicus	IC50	=	30000.0	nM	PMID[453621]
NPT4747	Protein Family	Cyclooxygenase	Bos taurus	IC50	=	14000.0	nM	PMID[453623]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	25.0	%	PMID[453623]
NPT792	Individual Protein	Arachidonate 15-lipoxygenase	Homo sapiens	IC50	=	110.0	nM	PMID[453624]
NPT89	Individual Protein	Seed lipoxygenase-1	Glycine max	IC50	=	180.0	nM	PMID[453624]
NPT2	Others	Unspecified		IC50	=	210000.0	nM	PMID[453628]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	IC50	=	100.0	nM	PMID[453629]
NPT605	Organism	Homo sapiens	Homo sapiens	IC50	=	8000.0	nM	PMID[453629]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Inhibition	=	70.0	%	PMID[453629]
NPT2	Others	Unspecified		IC50	=	183000.0	nM	PMID[453630]
NPT597	Organism	Spinacia oleracea	Spinacia oleracea	Fresh weight	=	20.5	ng g-1	PMID[453630]
NPT597	Organism	Spinacia oleracea	Spinacia oleracea	Fresh weight	=	165.3	ng g-1	PMID[453630]
NPT597	Organism	Spinacia oleracea	Spinacia oleracea	Fresh weight	=	128.5	ng g-1	PMID[453630]
NPT27	Others	Unspecified		kDPPH	>	100.0	M-1 s-1	PMID[453631]
NPT2	Others	Unspecified		Deoxyribose degradation	=	0.23	uM of MDA mM-1	PMID[453631]
NPT1559	Protein Family	Cyclooxygenase	Rattus norvegicus	IC50	>	50000.0	nM	PMID[453632]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	0.1	mg ear-1	PMID[453632]
NPT32	Organism	Mus musculus	Mus musculus	ED50	>	100.0	mg.kg-1	PMID[453632]
NPT1889	Subcellular	Liposome		IC50	=	2000.0	nM	PMID[453633]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Inhibition	=	64.0	%	PMID[453635]
NPT89	Individual Protein	Seed lipoxygenase-1	Glycine max	IC50	>	10000.0	nM	PMID[453637]
NPT89	Individual Protein	Seed lipoxygenase-1	Glycine max	IC50	=	3500.0	nM	PMID[453637]
NPT89	Individual Protein	Seed lipoxygenase-1	Glycine max	Inhibition	=	83.7	%	PMID[453638]
NPT89	Individual Protein	Seed lipoxygenase-1	Glycine max	Inhibition	=	94.7	%	PMID[453638]
NPT610	Others	Molecular identity unknown		Lipid peroxidation	=	26.1	%	PMID[453638]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Inhibition	=	15.1	%	PMID[453639]
NPT89	Individual Protein	Seed lipoxygenase-1	Glycine max	IC50	=	3500.0	nM	PMID[453639]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Inhibition	=	45.8	%	PMID[453639]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Inhibition	=	62.5	%	PMID[453639]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ED50	=	205.0	mg.kg-1	PMID[453639]
NPT89	Individual Protein	Seed lipoxygenase-1	Glycine max	IC50	=	1300.0	nM	PMID[453640]
NPT89	Individual Protein	Seed lipoxygenase-1	Glycine max	Inhibition	=	83.7	%	PMID[453641]
NPT20529	NON-MOLECULAR	NON-PROTEIN TARGET	n.a.	Activity	=	81.0	%	PMID[453641]
NPT20529	NON-MOLECULAR	NON-PROTEIN TARGET	n.a.	Activity	=	82.6	%	PMID[453641]
NPT20529	NON-MOLECULAR	NON-PROTEIN TARGET	n.a.	Activity	=	96.5	%	PMID[453641]
NPT20529	NON-MOLECULAR	NON-PROTEIN TARGET	n.a.	Activity	=	98.0	%	PMID[453641]
NPT2	Others	Unspecified		Activity	=	81.0	%	PMID[453643]
NPT2	Others	Unspecified		Activity	=	83.0	%	PMID[453643]
NPT1	Others	Radical scavenging activity		Activity	=	68.0	%	PMID[453644]
NPT1	Others	Radical scavenging activity		Activity	=	72.0	%	PMID[453644]
NPT1	Others	Radical scavenging activity		Activity	=	81.0	%	PMID[453644]
NPT1	Others	Radical scavenging activity		Activity	=	82.6	%	PMID[453644]
NPT792	Individual Protein	Arachidonate 15-lipoxygenase	Homo sapiens	IC50	=	3800.0	nM	PMID[453645]
NPT792	Individual Protein	Arachidonate 15-lipoxygenase	Homo sapiens	IC50	=	250.0	nM	PMID[453646]
NPT2	Others	Unspecified		Ratio IC50	=	0.1	n.a.	PMID[453646]
NPT2	Others	Unspecified		Inhibition	=	-4.5	%	PMID[453647]
NPT2	Others	Unspecified		IC50	=	14470.0	nM	PMID[453647]
NPT35	Others	n.a.		T1/2	=	3.0	hr	PMID[453648]
NPT35	Others	n.a.		Stability	=	50.0	%	PMID[453648]
NPT20529	NON-MOLECULAR	NON-PROTEIN TARGET	n.a.	IC50	=	29000.0	nM	PMID[453649]
NPT2	Others	Unspecified		IC50	=	1000.0	nM	PMID[453649]
NPT1	Others	Radical scavenging activity		IC50	=	12.0	ug.mL-1	PMID[453651]
NPT20529	NON-MOLECULAR	NON-PROTEIN TARGET	n.a.	Inhibition	=	78.68	%	PMID[453652]
NPT20529	NON-MOLECULAR	NON-PROTEIN TARGET	n.a.	IC50	=	6000.0	nM	PMID[453652]
NPT2	Others	Unspecified		IC50	=	1000.0	nM	PMID[453654]
NPT20529	NON-MOLECULAR	NON-PROTEIN TARGET	n.a.	IC50	=	29000.0	nM	PMID[453654]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	50.0	%	PMID[453657]
NPT792	Individual Protein	Arachidonate 15-lipoxygenase	Homo sapiens	IC50	=	110.0	nM	PMID[453658]
NPT2	Others	Unspecified		IC50	=	5100.0	nM	PMID[453658]
NPT2	Others	Unspecified		Ratio IC50	=	46.0	n.a.	PMID[453658]
NPT2	Others	Unspecified		Ratio IC50	=	28.0	n.a.	PMID[453658]
NPT2	Others	Unspecified		Ratio IC50	=	2.0	n.a.	PMID[453658]
NPT2	Others	Unspecified		IC50	=	2000.0	nM	PMID[453661]
NPT2	Others	Unspecified		Activity	=	0.23	umol	PMID[453661]
NPT1	Others	Radical scavenging activity		Activity	>	100.0	/M/s	PMID[453661]
NPT1	Others	Radical scavenging activity		Activity	=	68.0	%	PMID[453662]
NPT1	Others	Radical scavenging activity		Activity	=	72.0	%	PMID[453662]
NPT1	Others	Radical scavenging activity		Activity	=	81.0	%	PMID[453662]
NPT1	Others	Radical scavenging activity		Activity	=	83.0	%	PMID[453662]
NPT2	Others	Unspecified		Inhibition	=	84.0	%	PMID[453663]
NPT20529	NON-MOLECULAR	NON-PROTEIN TARGET	n.a.	Activity	=	81.0	%	PMID[453663]
NPT20529	NON-MOLECULAR	NON-PROTEIN TARGET	n.a.	Activity	=	83.0	%	PMID[453663]
NPT20529	NON-MOLECULAR	NON-PROTEIN TARGET	n.a.	Activity	=	97.0	%	PMID[453663]
NPT20529	NON-MOLECULAR	NON-PROTEIN TARGET	n.a.	Activity	=	98.0	%	PMID[453663]
NPT1	Others	Radical scavenging activity		Activity	=	83.0	%	PMID[453664]
NPT1	Others	Radical scavenging activity		Activity	=	81.0	%	PMID[453664]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	75.0	mg.kg-1	PMID[453665]
NPT1	Others	Radical scavenging activity		Activity	=	63.0	%	PMID[453666]
NPT1	Others	Radical scavenging activity		Activity	=	65.0	%	PMID[453666]
NPT1	Others	Radical scavenging activity		Activity	=	81.0	%	PMID[453666]
NPT1	Others	Radical scavenging activity		Activity	=	83.0	%	PMID[453666]
NPT1	Others	Radical scavenging activity		Activity	=	83.0	%	PMID[453667]
NPT1	Others	Radical scavenging activity		Activity	=	81.0	%	PMID[453667]
NPT2	Others	Unspecified		IC50	=	40000.0	nM	PMID[453668]
NPT1	Others	Radical scavenging activity		Activity	=	81.0	%	PMID[453668]
NPT1	Others	Radical scavenging activity		Activity	=	83.0	%	PMID[453668]
NPT1	Others	Radical scavenging activity		Activity	=	84.0	%	PMID[453668]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Inhibition	=	15.1	%	PMID[453669]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ED50	=	205.0	mg.kg-1	PMID[453669]
NPT1	Others	Radical scavenging activity		Activity	=	68.0	%	PMID[453671]
NPT1	Others	Radical scavenging activity		Activity	=	72.0	%	PMID[453671]
NPT1	Others	Radical scavenging activity		Activity	=	81.0	%	PMID[453671]
NPT1	Others	Radical scavenging activity		Activity	=	83.0	%	PMID[453671]
NPT35	Others	n.a.		LogP	=	5.8	n.a.	PMID[453673]
NPT792	Individual Protein	Arachidonate 15-lipoxygenase	Homo sapiens	IC50	=	1100.0	nM	PMID[453675]
NPT2	Others	Unspecified		IC50	=	11000.0	nM	PMID[453675]
NPT2	Others	Unspecified		IC50	=	54000.0	nM	PMID[453675]
NPT1	Others	Radical scavenging activity		Activity	=	81.0	%	PMID[453676]
NPT1	Others	Radical scavenging activity		Activity	=	83.0	%	PMID[453676]
NPT1	Others	Radical scavenging activity		Activity	=	93.0	%	PMID[453676]
NPT1	Others	Radical scavenging activity		Activity	=	97.0	%	PMID[453676]
NPT1	Others	Radical scavenging activity		Activity	=	84.0	%	PMID[453677]
NPT1	Others	Radical scavenging activity		Activity	=	83.0	%	PMID[453677]
NPT2	Others	Unspecified		Inhibition	=	40.0	%	PMID[453677]
NPT1	Others	Radical scavenging activity		IC50	=	4200.0	nM	PMID[453678]
NPT6	Organism	Plasmodium falciparum	Plasmodium falciparum	IC50	=	12589.25	nM	PMID[453681]
NPT6	Organism	Plasmodium falciparum	Plasmodium falciparum	IC50	=	3981.07	nM	PMID[453681]
NPT6	Organism	Plasmodium falciparum	Plasmodium falciparum	IC50	=	5011.87	nM	PMID[453681]
NPT6	Organism	Plasmodium falciparum	Plasmodium falciparum	IC50	=	10000.0	nM	PMID[453681]
NPT6	Organism	Plasmodium falciparum	Plasmodium falciparum	IC50	=	7943.28	nM	PMID[453681]
NPT1188	Organism	Plasmodium yoelii yoelii	Plasmodium yoelii yoelii	IC50	=	30000.0	nM	PMID[453682]
NPT2	Others	Unspecified		Selectivity Index	>	3.33	n.a.	PMID[453682]
NPT2	Others	Unspecified		IC50	=	13000.0	nM	PMID[453683]
NPT2264	Protein Family	Heat shock protein HSP90	Homo sapiens	IC50	=	2623.2	nM	PMID[453686]
NPT2	Others	Unspecified		Potency	=	8912.5	nM	PMID[453684]
NPT2264	Protein Family	Heat shock protein HSP90	Homo sapiens	IC50	>	30000.0	nM	PMID[453686]
NPT2	Others	Unspecified		IC50	=	22310.0	nM	PMID[453686]
NPT94	Individual Protein	Aldehyde dehydrogenase 1A1	Homo sapiens	Potency	=	10000.0	nM	PMID[453685]
NPT94	Individual Protein	Aldehyde dehydrogenase 1A1	Homo sapiens	Potency	=	28183.8	nM	PMID[453684]
NPT795	Individual Protein	Zinc finger protein mex-5	Caenorhabditis elegans	EC50	=	8755.0	nM	PMID[453686]
NPT2	Others	Unspecified		EC50	>	110000.0	nM	PMID[453686]
NPT2	Others	Unspecified		EC50	=	9480.0	nM	PMID[453686]
NPT2	Others	Unspecified		EC50	=	11180.0	nM	PMID[453686]
NPT792	Individual Protein	Arachidonate 15-lipoxygenase	Homo sapiens	Potency	=	100.0	nM	PMID[453686]
NPT197	Protein-Protein Interaction	Menin/Histone-lysine N-methyltransferase MLL	Homo sapiens	Potency	=	39810.7	nM	PMID[453684]
NPT797	Individual Protein	Cytoplasmic zinc-finger protein	Caenorhabditis elegans	EC50	=	26111.0	nM	PMID[453686]
NPT2	Others	Unspecified		Potency	=	28183.8	nM	PMID[453685]
NPT1	Others	Radical scavenging activity		Activity	=	93.0	%	PMID[453687]
NPT1	Others	Radical scavenging activity		Activity	=	96.0	%	PMID[453687]
NPT2	Others	Unspecified		Inhibition	=	84.0	%	PMID[453687]
NPT20529	NON-MOLECULAR	NON-PROTEIN TARGET	n.a.	Activity	=	83.0	%	PMID[453688]
NPT20529	NON-MOLECULAR	NON-PROTEIN TARGET	n.a.	Activity	=	81.0	%	PMID[453688]
NPT2	Others	Unspecified		IC50	=	28000.0	nM	PMID[453688]
NPT1	Others	Radical scavenging activity		Activity	=	77.0	%	PMID[453689]
NPT1	Others	Radical scavenging activity		Activity	=	84.0	%	PMID[453689]
NPT1	Others	Radical scavenging activity		Activity	=	81.0	%	PMID[453689]
NPT1	Others	Radical scavenging activity		Activity	=	91.0	%	PMID[453689]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	33.0	%	PMID[453690]
NPT32	Organism	Mus musculus	Mus musculus	ID50	=	0.54	umol	PMID[453690]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	19.0	%	PMID[453690]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	65.0	%	PMID[453690]
NPT2	Others	Unspecified		IC50	=	515000.0	nM	PMID[453691]
NPT35	Others	n.a.		Activity	=	84.8	%	PMID[453691]
NPT35	Others	n.a.		Activity	=	83.1	%	PMID[453691]
NPT35	Others	n.a.		Activity	=	81.0	%	PMID[453691]
NPT35	Others	n.a.		Activity	=	82.6	%	PMID[453691]
NPT35	Others	n.a.		Activity	=	90.3	%	PMID[453691]
NPT35	Others	n.a.		Activity	=	94.6	%	PMID[453691]
NPT1	Others	Radical scavenging activity		Inhibition	=	81.0	%	PMID[453692]
NPT1	Others	Radical scavenging activity		Inhibition	=	83.0	%	PMID[453692]
NPT2	Others	Unspecified		Inhibition	=	40.0	%	PMID[453692]
NPT2	Others	Unspecified		Inhibition	=	84.0	%	PMID[453692]
NPT20596	PHENOTYPE	Hepatotoxicity	n.a.	Composite Activity - Active	=	0.0	n.a.	PMID[453694]
NPT20596	PHENOTYPE	Hepatotoxicity	n.a.	Composite Activity - Marginal	=	0.0	n.a.	PMID[453694]
NPT20596	PHENOTYPE	Hepatotoxicity	n.a.	Alkaline Phosphatase Increase - Index Value	=	0.0	n.a.	PMID[453694]
NPT20596	PHENOTYPE	Hepatotoxicity	n.a.	Alkaline Phosphatase Increase - Number of Reports	<	4.0	n.a.	PMID[453694]
NPT20596	PHENOTYPE	Hepatotoxicity	n.a.	SGOT Increase - Index Value	=	0.0	n.a.	PMID[453694]
NPT20596	PHENOTYPE	Hepatotoxicity	n.a.	SGOT Increase - Number of Reports	<	4.0	n.a.	PMID[453694]
NPT20596	PHENOTYPE	Hepatotoxicity	n.a.	SGPT Increase - Index Value	=	0.0	n.a.	PMID[453694]
NPT20596	PHENOTYPE	Hepatotoxicity	n.a.	SGPT Increase - Number of Reports	<	4.0	n.a.	PMID[453694]
NPT20596	PHENOTYPE	Hepatotoxicity	n.a.	LDH Increase - Index Value	=	0.0	n.a.	PMID[453694]
NPT20596	PHENOTYPE	Hepatotoxicity	n.a.	LDH Increase - Number of Reports	<	4.0	n.a.	PMID[453694]
NPT20596	PHENOTYPE	Hepatotoxicity	n.a.	GGT Increase - Index Value	=	0.0	n.a.	PMID[453694]
NPT20596	PHENOTYPE	Hepatotoxicity	n.a.	GGT Increase - Number of Reports	<	4.0	n.a.	PMID[453694]
NPT533	Protein-Protein Interaction	Runt-related transcription factor 1/Core-binding factor subunit beta	Homo sapiens	Potency	n.a.	25118.9	nM	PMID[453685]
NPT533	Protein-Protein Interaction	Runt-related transcription factor 1/Core-binding factor subunit beta	Homo sapiens	Potency	n.a.	39810.7	nM	PMID[453684]
NPT1	Others	Radical scavenging activity		Activity	=	81.0	%	PMID[453695]
NPT2	Others	Unspecified		Inhibition	=	84.0	%	PMID[453695]
NPT1	Others	Radical scavenging activity		Activity	=	68.0	%	PMID[453696]
NPT1	Others	Radical scavenging activity		Activity	=	81.0	%	PMID[453696]
NPT1	Others	Radical scavenging activity		Activity	=	83.0	%	PMID[453696]
NPT792	Individual Protein	Arachidonate 15-lipoxygenase	Homo sapiens	IC50	=	5100.0	nM	PMID[453697]
NPT2	Others	Unspecified		AC50	>	420000.0	nM	PMID[453686]
NPT6	Organism	Plasmodium falciparum	Plasmodium falciparum	Potency	n.a.	15101.4	nM	PMID[453698]
NPT8	Individual Protein	DNA polymerase iota	Homo sapiens	Potency	n.a.	56234.1	nM	PMID[453699]
NPT905	Individual Protein	Glucose-6-phosphate 1-dehydrogenase	Homo sapiens	IC50	>	80000.0	nM	PMID[453686]
NPT7	Individual Protein	Thioredoxin reductase 1, cytoplasmic	Rattus norvegicus	Potency	n.a.	22387.2	nM	PMID[453699]
NPT7	Individual Protein	Thioredoxin reductase 1, cytoplasmic	Rattus norvegicus	Potency	n.a.	19952.6	nM	PMID[453686]
NPT803	Individual Protein	Flap endonuclease 1	Homo sapiens	Potency	n.a.	44668.4	nM	PMID[453699]
NPT8	Individual Protein	DNA polymerase iota	Homo sapiens	Potency	n.a.	44668.4	nM	PMID[453686]
NPT803	Individual Protein	Flap endonuclease 1	Homo sapiens	Potency	n.a.	22387.2	nM	PMID[453686]
NPT9	Individual Protein	DNA polymerase eta	Homo sapiens	Potency	n.a.	28183.8	nM	PMID[453686]
NPT2	Others	Unspecified		Potency	n.a.	1995.3	nM	PMID[453686]
NPT6	Organism	Plasmodium falciparum	Plasmodium falciparum	Potency	n.a.	19011.5	nM	PMID[453698]
NPT2	Others	Unspecified		Potency	n.a.	1578.5	nM	PMID[453684]
NPT2	Others	Unspecified		Potency	n.a.	1578.5	nM	PMID[453686]
NPT2	Others	Unspecified		Potency	n.a.	1578.5	nM	PMID[453698]
NPT2	Others	Unspecified		Potency	n.a.	1578.5	nM	PMID[453685]
NPT2	Others	Unspecified		Potency	n.a.	14125.4	nM	PMID[453701]
NPT2	Others	Unspecified		Inhibition	=	84.0	%	PMID[453702]
NPT1	Others	Radical scavenging activity		Activity	=	83.0	%	PMID[453702]
NPT1	Others	Radical scavenging activity		Activity	=	81.0	%	PMID[453702]
NPT2	Others	Unspecified		IC50	=	9820.0	nM	PMID[453704]
NPT2	Others	Unspecified		Inhibition	=	88.84	%	PMID[453704]
NPT89	Individual Protein	Seed lipoxygenase-1	Glycine max	IC50	=	31300.0	nM	PMID[453706]
NPT1	Others	Radical scavenging activity		Activity	=	80.0	%	PMID[453709]
NPT1	Others	Radical scavenging activity		Activity	=	91.0	%	PMID[453709]
NPT2	Others	Unspecified		Inhibition	=	84.0	%	PMID[453709]
NPT2	Others	Unspecified		IC50	=	28000.0	nM	PMID[453709]
NPT1	Others	Radical scavenging activity		Activity	=	81.0	%	PMID[453710]
NPT2	Others	Unspecified		Inhibition	=	64.0	%	PMID[453710]
NPT1	Others	Radical scavenging activity		IC50	=	6200.0	nM	PMID[453712]
NPT2	Others	Unspecified		Potency	n.a.	44668.4	nM	PMID[453686]
NPT2	Others	Unspecified		Potency	n.a.	10000.0	nM	PMID[453686]
NPT821	Individual Protein	Werner syndrome ATP-dependent helicase	Homo sapiens	Potency	n.a.	17782.8	nM	PMID[453686]
NPT755	Individual Protein	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	Homo sapiens	Potency	n.a.	89125.1	nM	PMID[453686]
NPT2	Others	Unspecified		IC50	=	427000.0	nM	PMID[453713]
NPT2	Others	Unspecified		IC50	=	9300.0	nM	PMID[453713]
NPT1	Others	Radical scavenging activity		IC50	=	6200.0	nM	PMID[453714]
NPT1	Others	Radical scavenging activity		Inhibition	=	97.0	%	PMID[453715]
NPT1	Others	Radical scavenging activity		Inhibition	=	93.0	%	PMID[453715]
NPT1	Others	Radical scavenging activity		Inhibition	=	83.0	%	PMID[453715]
NPT1	Others	Radical scavenging activity		Inhibition	=	81.0	%	PMID[453715]
NPT22750	SINGLE PROTEIN	Uncharacterized protein	Solanum lycopersicum	IC50	=	50000.0	nM	PMID[453716]
NPT2	Others	Unspecified		IC50	=	32000.0	nM	PMID[453717]
NPT1	Others	Radical scavenging activity		Activity	=	81.0	%	PMID[453718]
NPT2	Others	Unspecified		IC50	=	28000.0	nM	PMID[453718]
NPT1	Others	Radical scavenging activity		Activity	=	83.0	%	PMID[453718]
NPT2	Others	Unspecified		Potency	n.a.	29092.9	nM	PMID[453686]
NPT1	Others	Radical scavenging activity		Activity	=	83.0	%	PMID[453719]
NPT1	Others	Radical scavenging activity		Activity	=	81.0	%	PMID[453719]
NPT2	Others	Unspecified		IC50	=	28000.0	nM	PMID[453719]
NPT792	Individual Protein	Arachidonate 15-lipoxygenase	Homo sapiens	Activity	=	0.0	%	PMID[453720]
NPT792	Individual Protein	Arachidonate 15-lipoxygenase	Homo sapiens	Inhibition	=	0.0	%	PMID[453720]
NPT2	Others	Unspecified		IC50	=	12400.0	nM	PMID[453721]
NPT2	Others	Unspecified		Inhibition	=	84.0	%	PMID[453725]
NPT2	Others	Unspecified		Potency	n.a.	7079.5	nM	PMID[453686]
NPT792	Individual Protein	Arachidonate 15-lipoxygenase	Homo sapiens	IC50	=	110.0	nM	PMID[453726]
NPT1	Others	Radical scavenging activity		Activity	=	77.0	%	PMID[453727]
NPT1	Others	Radical scavenging activity		Activity	=	81.0	%	PMID[453727]
NPT35	Others	n.a.		Inhibition	=	83.0	%	PMID[453728]
NPT35	Others	n.a.		Inhibition	=	84.0	%	PMID[453728]
NPT792	Individual Protein	Arachidonate 15-lipoxygenase	Homo sapiens	Activity	=	23.1	%	PMID[453729]
NPT22752	PROTEIN COMPLEX	Transcription factor AP1	Homo sapiens	IC50	=	7.9	nM	PMID[453730]
NPT35	Others	n.a.		Activity	=	80.0	%	PMID[453732]
NPT35	Others	n.a.		Activity	=	91.0	%	PMID[453732]
NPT77	Individual Protein	Transthyretin	Homo sapiens	EC50	=	8500.0	nM	PMID[453733]
NPT77	Individual Protein	Transthyretin	Homo sapiens	EC50	=	12600.0	nM	PMID[453733]
NPT77	Individual Protein	Transthyretin	Homo sapiens	Inhibition	<	20.0	%	PMID[453733]
NPT77	Individual Protein	Transthyretin	Homo sapiens	EC50	=	7300.0	nM	PMID[453733]
NPT35	Others	n.a.		K	=	2.78	10'-5/s	PMID[453734]
NPT35	Others	n.a.		Drug metabolism	=	33.09	%	PMID[453734]
NPT35	Others	n.a.		Stability	=	66.9	%	PMID[453734]
NPT35	Others	n.a.		Drug metabolism	=	12.91	%	PMID[453734]
NPT35	Others	n.a.		Stability	=	87.08	%	PMID[453734]
NPT35	Others	n.a.		T1/2	=	3.94	hr	PMID[453734]
NPT35	Others	n.a.		K	=	4.88	10'-5/s	PMID[453734]
NPT35	Others	n.a.		pKa	=	9.3	n.a.	PMID[453734]
NPT2	Others	Unspecified		IC50	=	1300.0	nM	PMID[453735]
NPT35	Others	n.a.		Activity	=	81.0	%	PMID[453736]
NPT2	Others	Unspecified		IC50	=	28000.0	nM	PMID[453736]
NPT35	Others	n.a.		Activity	=	83.0	%	PMID[453737]
NPT35	Others	n.a.		Activity	=	97.0	%	PMID[453737]
NPT2	Others	Unspecified		Inhibition	=	83.0	%	PMID[453737]
NPT2	Others	Unspecified		IC50	=	4500.0	nM	PMID[453737]
NPT35	Others	n.a.		IC50	=	20750.0	nM	PMID[453739]
NPT2	Others	Unspecified		Selectivity Index	=	15.0	n.a.	PMID[453741]
NPT35	Others	n.a.		Activity	=	83.0	%	PMID[453742]
NPT20555	ORGANISM	SARS-CoV-2	Severe acute respiratory syndrome coronavirus 2	Inhibition	=	84.75	%	PMID[453744]
NPT20555	ORGANISM	SARS-CoV-2	Severe acute respiratory syndrome coronavirus 2	Hit score	=	0.1128	n.a.	PMID[453745]
NPT2	Others	Unspecified		IC50	=	10340.0	nM	PMID[453746]
NPT2	Others	Unspecified		IC50	=	2100.0	nM	PMID[453748]
NPT2	Others	Unspecified		IC50	=	10250.0	nM	PMID[453749]
NPT35	Others	n.a.		Activity	=	93.0	%	PMID[453751]
NPT20556	SINGLE PROTEIN	Replicase polyprotein 1ab	Severe acute respiratory syndrome coronavirus 2	Inhibition	=	99.41	%	PMID[453752]
NPT20556	SINGLE PROTEIN	Replicase polyprotein 1ab	Severe acute respiratory syndrome coronavirus 2	Inhibition	=	99.43	%	PMID[453753]
NPT20556	SINGLE PROTEIN	Replicase polyprotein 1ab	Severe acute respiratory syndrome coronavirus 2	IC50	=	2590.0	nM	PMID[453753]
NPT22753	SINGLE PROTEIN	Replicase polyprotein 1ab	Middle East respiratory syndrome-related coronavirus (isolate UnitedKingdom/H123990006/2012) (Betacoronavirus England 1) (Humancoronavirus EMC)	IC50	>	10000.0	nM	PMID[453753]
NPT22753	SINGLE PROTEIN	Replicase polyprotein 1ab	Middle East respiratory syndrome-related coronavirus (isolate UnitedKingdom/H123990006/2012) (Betacoronavirus England 1) (Humancoronavirus EMC)	Inhibition	=	0.0	%	PMID[453753]
NPT20555	ORGANISM	SARS-CoV-2	Severe acute respiratory syndrome coronavirus 2	Inhibition	=	0.18	%	PMID[453754]
NPT20555	ORGANISM	SARS-CoV-2	Severe acute respiratory syndrome coronavirus 2	Inhibition	=	-0.07	%	PMID[453755]
NPT2	Others	Unspecified		IC50	=	26000.0	nM	PMID[453756]
NPT20555	ORGANISM	SARS-CoV-2	Severe acute respiratory syndrome coronavirus 2	IC50	>	100000.0	nM	PMID[453757]
NPT22224	CELL-LINE	Vero C1008	Chlorocebus sabaeus	CC50	n.a.	37200.0	nM	PMID[453757]
NPT22224	CELL-LINE	Vero C1008	Chlorocebus sabaeus	pCC50	n.a.	4.43	n.a.	PMID[453757]
NPT920	Individual Protein	Alpha-synuclein	Homo sapiens	IC50	=	210.0	nM	PMID[453759]
NPT920	Individual Protein	Alpha-synuclein	Homo sapiens	IC50	=	220.0	nM	PMID[453759]
NPT2	Others	Unspecified		Potency	n.a.	17.4	nM	PubChem BioAssay data set
NPT2	Others	Unspecified		Potency	n.a.	17228.9	nM	PubChem BioAssay data set
NPT2	Others	Unspecified		Potency	n.a.	68589.6	nM	PubChem BioAssay data set
NPT2	Others	Unspecified		Potency	n.a.	61644.8	nM	PubChem BioAssay data set
NPT2	Others	Unspecified		Potency	n.a.	61130.6	nM	PubChem BioAssay data set
NPT2	Others	Unspecified		Potency	n.a.	13685.4	nM	PubChem BioAssay data set
NPT2	Others	Unspecified		Potency	n.a.	27535.7	nM	PubChem BioAssay data set
NPT2	Others	Unspecified		Potency	n.a.	7695.9	nM	PubChem BioAssay data set
NPT2	Others	Unspecified		Potency	n.a.	54941	nM	PubChem BioAssay data set
NPT2	Others	Unspecified		Potency	n.a.	30637.9	nM	PubChem BioAssay data set
NPT2	Others	Unspecified		Potency	n.a.	38895.2	nM	PubChem BioAssay data set
NPT2	Others	Unspecified		Potency	n.a.	15355.3	nM	PubChem BioAssay data set
NPT2	Others	Unspecified		Potency	n.a.	43641.2	nM	PubChem BioAssay data set
NPT74	Individual Protein	Proto-oncogene c-JUN	Homo sapiens	Potency	n.a.	48966.2	nM	PubChem BioAssay data set
NPT2	Others	Unspecified		Potency	n.a.	1933.1	nM	PubChem BioAssay data set
NPT2	Others	Unspecified		Potency	n.a.	685.9	nM	PubChem BioAssay data set
NPT2	Others	Unspecified		Potency	n.a.	48966.2	nM	PubChem BioAssay data set
NPT2	Others	Unspecified		Potency	n.a.	6859	nM	PubChem BioAssay data set

☑ Note for Activity Records:
☉ The quantitative biological activities were primarily integrated from ChEMBL (Version-30) database and were also directly collected from PubMed literature. PubMed PMID was provided as the reference link for each activity record.

Chemically structural similarity: I. Similar Active Natural Products in NPASS

Top-200 similar NPs were calculated against the active-NP-set (includes 4,3285 NPs with experimentally-derived bioactivity available in NPASS)

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules. Tc lies between [0, 1] where '1' indicates the highest similarity. What is Tanimoto coefficient

● The left chart: Distribution of similarity level between NPC228343 and all remaining natural products in the NPASS database.
● The right table: Most similar natural products (Tc>=0.56 or Top200).

range	Tanimoto Coefficient
0-0.1	277
0.1-0.2	1678
0.2-0.3	4534
0.3-0.4	13643
0.4-0.5	5508
0.5-0.6	8642
0.6-0.7	5854
0.7-0.8	2169
0.8-0.85	297
0.85-0.9	74
0.9-0.95	18
0.95-1	3

Similarity Score	Similarity Level	Natural Product ID
1.0	High Similarity	NPC254833
0.9604	High Similarity	NPC239291
0.9505	High Similarity	NPC471511
0.9346	High Similarity	NPC120280
0.9333	High Similarity	NPC174096
0.9333	High Similarity	NPC120982
0.9333	High Similarity	NPC147634
0.9333	High Similarity	NPC226401
0.9333	High Similarity	NPC79793
0.932	High Similarity	NPC477814
0.9245	High Similarity	NPC179002
0.9245	High Similarity	NPC187583
0.9245	High Similarity	NPC257430
0.9238	High Similarity	NPC55617
0.9238	High Similarity	NPC62258
0.9216	High Similarity	NPC196479
0.9208	High Similarity	NPC223393
0.9126	High Similarity	NPC120719
0.9065	High Similarity	NPC297657
0.9018	High Similarity	NPC117780
0.9018	High Similarity	NPC242885
0.9018	High Similarity	NPC227217
0.9018	High Similarity	NPC95614
0.9018	High Similarity	NPC232316
0.9018	High Similarity	NPC165133
0.9018	High Similarity	NPC56214
0.901	High Similarity	NPC109955
0.8962	High Similarity	NPC233835
0.8929	High Similarity	NPC281298
0.8929	High Similarity	NPC310338
0.8919	High Similarity	NPC200988
0.8919	High Similarity	NPC175799
0.8919	High Similarity	NPC145023
0.8919	High Similarity	NPC610
0.8911	High Similarity	NPC132271
0.8911	High Similarity	NPC82664
0.8911	High Similarity	NPC292730
0.8911	High Similarity	NPC473388
0.8911	High Similarity	NPC216520
0.8899	High Similarity	NPC471485
0.8889	High Similarity	NPC268032
0.886	High Similarity	NPC160380
0.886	High Similarity	NPC38996
0.885	High Similarity	NPC475245
0.8839	High Similarity	NPC86198
0.8839	High Similarity	NPC144343
0.8839	High Similarity	NPC470626
0.8812	High Similarity	NPC107522
0.8812	High Similarity	NPC26244
0.8812	High Similarity	NPC274678
0.8807	High Similarity	NPC471179
0.8785	High Similarity	NPC11554
0.8783	High Similarity	NPC85488
0.8762	High Similarity	NPC323810
0.8761	High Similarity	NPC70084
0.8761	High Similarity	NPC470215
0.8761	High Similarity	NPC109371
0.8761	High Similarity	NPC217174
0.8761	High Similarity	NPC470214
0.875	High Similarity	NPC293619
0.875	High Similarity	NPC277588
0.875	High Similarity	NPC16030
0.875	High Similarity	NPC110764
0.8739	High Similarity	NPC472893
0.8738	High Similarity	NPC92730
0.8713	High Similarity	NPC76938
0.8713	High Similarity	NPC151715
0.8707	High Similarity	NPC317769
0.8707	High Similarity	NPC280704
0.8707	High Similarity	NPC31344
0.8696	High Similarity	NPC237667
0.8661	High Similarity	NPC277394
0.8661	High Similarity	NPC299252
0.8661	High Similarity	NPC61062
0.8641	High Similarity	NPC225464
0.8636	High Similarity	NPC51698
0.8627	High Similarity	NPC32714
0.8611	High Similarity	NPC58427
0.8611	High Similarity	NPC114392
0.8611	High Similarity	NPC105727
0.8611	High Similarity	NPC34864
0.8609	High Similarity	NPC98305
0.8609	High Similarity	NPC24125
0.8609	High Similarity	NPC207613
0.8596	High Similarity	NPC191866
0.8585	High Similarity	NPC12278
0.8585	High Similarity	NPC52087
0.8584	High Similarity	NPC278652
0.8559	High Similarity	NPC29008
0.8559	High Similarity	NPC9067
0.8559	High Similarity	NPC317869
0.8559	High Similarity	NPC266705
0.8559	High Similarity	NPC228771
0.8559	High Similarity	NPC148627
0.8558	High Similarity	NPC131587
0.8547	High Similarity	NPC473451
0.8547	High Similarity	NPC53567
0.8534	High Similarity	NPC324571
0.8534	High Similarity	NPC470212
0.8534	High Similarity	NPC39029
0.8534	High Similarity	NPC54872
0.8534	High Similarity	NPC343720
0.8534	High Similarity	NPC312675
0.8534	High Similarity	NPC473853
0.8534	High Similarity	NPC262156
0.8534	High Similarity	NPC113865
0.8534	High Similarity	NPC184651
0.8522	High Similarity	NPC265454
0.8522	High Similarity	NPC34634
0.8519	High Similarity	NPC176527
0.8515	High Similarity	NPC45040
0.8515	High Similarity	NPC304541
0.8509	High Similarity	NPC474040
0.8505	High Similarity	NPC138942
0.8491	Intermediate Similarity	NPC168829
0.8487	Intermediate Similarity	NPC274356
0.8476	Intermediate Similarity	NPC294741
0.8475	Intermediate Similarity	NPC257682
0.8475	Intermediate Similarity	NPC146355
0.8475	Intermediate Similarity	NPC131747
0.8462	Intermediate Similarity	NPC32674
0.8455	Intermediate Similarity	NPC44732
0.8448	Intermediate Similarity	NPC470848
0.8448	Intermediate Similarity	NPC470849
0.8435	Intermediate Similarity	NPC141791
0.8435	Intermediate Similarity	NPC176893
0.8435	Intermediate Similarity	NPC268572
0.8435	Intermediate Similarity	NPC263386
0.8431	Intermediate Similarity	NPC162314
0.8431	Intermediate Similarity	NPC306884
0.8431	Intermediate Similarity	NPC210497
0.8431	Intermediate Similarity	NPC94139
0.8431	Intermediate Similarity	NPC3358
0.8431	Intermediate Similarity	NPC147284
0.8426	Intermediate Similarity	NPC271274
0.8421	Intermediate Similarity	NPC86947
0.8417	Intermediate Similarity	NPC165045
0.8417	Intermediate Similarity	NPC5428
0.8417	Intermediate Similarity	NPC118533
0.8417	Intermediate Similarity	NPC127587
0.8416	Intermediate Similarity	NPC192
0.8411	Intermediate Similarity	NPC79672
0.8411	Intermediate Similarity	NPC288411
0.8396	Intermediate Similarity	NPC91461
0.8396	Intermediate Similarity	NPC12221
0.8396	Intermediate Similarity	NPC7686
0.8396	Intermediate Similarity	NPC40258
0.8393	Intermediate Similarity	NPC165106
0.839	Intermediate Similarity	NPC471693
0.839	Intermediate Similarity	NPC136319
0.8381	Intermediate Similarity	NPC132078
0.8381	Intermediate Similarity	NPC216468
0.8381	Intermediate Similarity	NPC51333
0.8381	Intermediate Similarity	NPC78119
0.8378	Intermediate Similarity	NPC308689
0.8378	Intermediate Similarity	NPC95716
0.8364	Intermediate Similarity	NPC58865
0.8362	Intermediate Similarity	NPC472071
0.835	Intermediate Similarity	NPC27323
0.835	Intermediate Similarity	NPC316301
0.835	Intermediate Similarity	NPC128062
0.8349	Intermediate Similarity	NPC320439
0.8349	Intermediate Similarity	NPC151477
0.8348	Intermediate Similarity	NPC122009
0.8347	Intermediate Similarity	NPC184733
0.8347	Intermediate Similarity	NPC45774
0.8347	Intermediate Similarity	NPC307050
0.8347	Intermediate Similarity	NPC11258
0.8347	Intermediate Similarity	NPC128208
0.8347	Intermediate Similarity	NPC277458
0.8347	Intermediate Similarity	NPC21867
0.8347	Intermediate Similarity	NPC129570
0.8347	Intermediate Similarity	NPC282703
0.8333	Intermediate Similarity	NPC76451
0.8319	Intermediate Similarity	NPC224342
0.8319	Intermediate Similarity	NPC12656
0.8318	Intermediate Similarity	NPC477802
0.8318	Intermediate Similarity	NPC477801
0.8317	Intermediate Similarity	NPC242240
0.8317	Intermediate Similarity	NPC318325
0.8317	Intermediate Similarity	NPC258219
0.8317	Intermediate Similarity	NPC280347
0.8317	Intermediate Similarity	NPC123273
0.8317	Intermediate Similarity	NPC177420
0.8305	Intermediate Similarity	NPC86900
0.8305	Intermediate Similarity	NPC321402
0.8305	Intermediate Similarity	NPC471794
0.8305	Intermediate Similarity	NPC30462
0.8304	Intermediate Similarity	NPC43525
0.8304	Intermediate Similarity	NPC46940
0.8302	Intermediate Similarity	NPC213730
0.8302	Intermediate Similarity	NPC72729
0.8291	Intermediate Similarity	NPC470414
0.8288	Intermediate Similarity	NPC222084
0.8288	Intermediate Similarity	NPC296683
0.8288	Intermediate Similarity	NPC13482
0.8286	Intermediate Similarity	NPC77492
0.8286	Intermediate Similarity	NPC79241
0.8286	Intermediate Similarity	NPC6597
0.8279	Intermediate Similarity	NPC475875

Chemically structural similarity: II. Similar Clinical/Approved Drugs

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules.

● The left chart: Distribution of similarity level between NPC228343 and all drugs/candidates.
● The right table: Most similar clinical/approved drugs (Tc>=0.56 or Top200).

range	Tanimoto Coefficient
0-0.1	276
0.1-0.2	1033
0.2-0.3	1250
0.3-0.4	2886
0.4-0.5	1944
0.5-0.6	1177
0.6-0.7	471
0.7-0.8	99
0.8-0.85	7
0.85-0.9	4
0.9-0.95	1
0.95-1	2

Similarity Score	Similarity Level	Drug ID	Developmental Stage
1.0	High Similarity	NPD3022	Approved
1.0	High Similarity	NPD3021	Approved
0.9109	High Similarity	NPD3020	Approved
0.8812	High Similarity	NPD2859	Approved
0.8812	High Similarity	NPD2860	Approved
0.8713	High Similarity	NPD2933	Approved
0.8713	High Similarity	NPD2934	Approved
0.8393	Intermediate Similarity	NPD5283	Phase 1
0.835	Intermediate Similarity	NPD1432	Clinical (unspecified phase)
0.8214	Intermediate Similarity	NPD228	Approved
0.819	Intermediate Similarity	NPD288	Approved
0.8095	Intermediate Similarity	NPD844	Approved
0.7984	Intermediate Similarity	NPD3027	Phase 3
0.7982	Intermediate Similarity	NPD9377	Approved
0.7982	Intermediate Similarity	NPD7635	Approved
0.7982	Intermediate Similarity	NPD9379	Approved
0.7963	Intermediate Similarity	NPD1242	Phase 1
0.7963	Intermediate Similarity	NPD289	Clinical (unspecified phase)
0.7951	Intermediate Similarity	NPD3055	Approved
0.7951	Intermediate Similarity	NPD3053	Approved
0.7934	Intermediate Similarity	NPD4379	Clinical (unspecified phase)
0.792	Intermediate Similarity	NPD2028	Clinical (unspecified phase)
0.7917	Intermediate Similarity	NPD3092	Approved
0.7913	Intermediate Similarity	NPD2234	Approved
0.7913	Intermediate Similarity	NPD2228	Approved
0.7913	Intermediate Similarity	NPD2229	Approved
0.7905	Intermediate Similarity	NPD845	Approved
0.7881	Intermediate Similarity	NPD3091	Approved
0.7876	Intermediate Similarity	NPD4750	Phase 3
0.7876	Intermediate Similarity	NPD1792	Phase 2
0.7869	Intermediate Similarity	NPD5311	Approved
0.7869	Intermediate Similarity	NPD5310	Approved
0.7822	Intermediate Similarity	NPD111	Approved
0.7815	Intermediate Similarity	NPD4093	Discontinued
0.7807	Intermediate Similarity	NPD9280	Clinical (unspecified phase)
0.7805	Intermediate Similarity	NPD3094	Phase 2
0.7798	Intermediate Similarity	NPD3028	Approved
0.7787	Intermediate Similarity	NPD3600	Clinical (unspecified phase)
0.7768	Intermediate Similarity	NPD1444	Approved
0.7768	Intermediate Similarity	NPD1445	Approved
0.7757	Intermediate Similarity	NPD1809	Phase 2
0.775	Intermediate Similarity	NPD2932	Approved
0.775	Intermediate Similarity	NPD4059	Approved
0.775	Intermediate Similarity	NPD3019	Approved
0.7727	Intermediate Similarity	NPD940	Approved
0.7727	Intermediate Similarity	NPD846	Approved
0.7699	Intermediate Similarity	NPD2342	Discontinued
0.7656	Intermediate Similarity	NPD3619	Clinical (unspecified phase)
0.7656	Intermediate Similarity	NPD3620	Phase 2
0.7619	Intermediate Similarity	NPD1529	Clinical (unspecified phase)
0.7603	Intermediate Similarity	NPD3095	Discontinued
0.7561	Intermediate Similarity	NPD2337	Clinical (unspecified phase)
0.754	Intermediate Similarity	NPD1530	Clinical (unspecified phase)
0.752	Intermediate Similarity	NPD4339	Clinical (unspecified phase)
0.7519	Intermediate Similarity	NPD4060	Phase 1
0.7519	Intermediate Similarity	NPD3062	Approved
0.7519	Intermediate Similarity	NPD3059	Approved
0.7519	Intermediate Similarity	NPD3061	Approved
0.746	Intermediate Similarity	NPD257	Approved
0.746	Intermediate Similarity	NPD258	Approved
0.7459	Intermediate Similarity	NPD9384	Approved
0.7459	Intermediate Similarity	NPD9381	Approved
0.7459	Intermediate Similarity	NPD1751	Approved
0.7459	Intermediate Similarity	NPD2286	Discontinued
0.744	Intermediate Similarity	NPD9634	Clinical (unspecified phase)
0.7438	Intermediate Similarity	NPD5304	Approved
0.7438	Intermediate Similarity	NPD5303	Approved
0.7407	Intermediate Similarity	NPD8166	Discontinued
0.7405	Intermediate Similarity	NPD5314	Approved
0.7385	Intermediate Similarity	NPD943	Approved
0.7385	Intermediate Similarity	NPD1612	Clinical (unspecified phase)
0.7385	Intermediate Similarity	NPD1613	Approved
0.7368	Intermediate Similarity	NPD1632	Clinical (unspecified phase)
0.736	Intermediate Similarity	NPD9622	Approved
0.7355	Intermediate Similarity	NPD5536	Phase 2
0.7339	Intermediate Similarity	NPD5350	Clinical (unspecified phase)
0.7339	Intermediate Similarity	NPD5351	Clinical (unspecified phase)
0.7333	Intermediate Similarity	NPD6671	Approved
0.7333	Intermediate Similarity	NPD7157	Approved
0.7328	Intermediate Similarity	NPD2684	Approved
0.7317	Intermediate Similarity	NPD4589	Approved
0.7317	Intermediate Similarity	NPD5238	Clinical (unspecified phase)
0.7313	Intermediate Similarity	NPD2029	Clinical (unspecified phase)
0.7313	Intermediate Similarity	NPD7266	Discontinued
0.7288	Intermediate Similarity	NPD6124	Clinical (unspecified phase)
0.7287	Intermediate Similarity	NPD7095	Approved
0.7273	Intermediate Similarity	NPD7325	Clinical (unspecified phase)
0.7266	Intermediate Similarity	NPD2861	Phase 2
0.7266	Intermediate Similarity	NPD5736	Approved
0.7258	Intermediate Similarity	NPD3026	Approved
0.7258	Intermediate Similarity	NPD3023	Approved
0.7252	Intermediate Similarity	NPD826	Approved
0.7252	Intermediate Similarity	NPD825	Approved
0.7252	Intermediate Similarity	NPD1558	Phase 1
0.7236	Intermediate Similarity	NPD3024	Approved
0.7236	Intermediate Similarity	NPD3025	Approved
0.7231	Intermediate Similarity	NPD5111	Phase 2
0.7231	Intermediate Similarity	NPD5109	Approved
0.7231	Intermediate Similarity	NPD5110	Phase 2
0.7227	Intermediate Similarity	NPD7843	Approved
0.7209	Intermediate Similarity	NPD4908	Phase 1
0.7188	Intermediate Similarity	NPD2194	Approved
0.7188	Intermediate Similarity	NPD9621	Approved
0.7188	Intermediate Similarity	NPD9619	Approved
0.7188	Intermediate Similarity	NPD9620	Approved
0.7188	Intermediate Similarity	NPD6584	Phase 3
0.7188	Intermediate Similarity	NPD2195	Approved
0.7177	Intermediate Similarity	NPD2667	Approved
0.7177	Intermediate Similarity	NPD2668	Approved
0.7176	Intermediate Similarity	NPD2674	Phase 3
0.7174	Intermediate Similarity	NPD2422	Clinical (unspecified phase)
0.7167	Intermediate Similarity	NPD7159	Clinical (unspecified phase)
0.7167	Intermediate Similarity	NPD4869	Clinical (unspecified phase)
0.7154	Intermediate Similarity	NPD5156	Approved
0.7154	Intermediate Similarity	NPD2226	Clinical (unspecified phase)
0.7154	Intermediate Similarity	NPD5155	Approved
0.7143	Intermediate Similarity	NPD2232	Approved
0.7143	Intermediate Similarity	NPD2230	Approved
0.7143	Intermediate Similarity	NPD2233	Approved
0.7132	Intermediate Similarity	NPD3637	Approved
0.7132	Intermediate Similarity	NPD3636	Approved
0.7132	Intermediate Similarity	NPD3635	Approved
0.7132	Intermediate Similarity	NPD9569	Approved
0.713	Intermediate Similarity	NPD9608	Approved
0.713	Intermediate Similarity	NPD9610	Approved
0.7122	Intermediate Similarity	NPD2421	Approved
0.7122	Intermediate Similarity	NPD2420	Approved
0.7119	Intermediate Similarity	NPD5451	Approved
0.7107	Intermediate Similarity	NPD497	Approved
0.7107	Intermediate Similarity	NPD1791	Approved
0.7107	Intermediate Similarity	NPD475	Phase 2
0.7107	Intermediate Similarity	NPD1476	Clinical (unspecified phase)
0.7107	Intermediate Similarity	NPD1793	Approved
0.7099	Intermediate Similarity	NPD598	Approved
0.7099	Intermediate Similarity	NPD601	Approved
0.7099	Intermediate Similarity	NPD4907	Clinical (unspecified phase)
0.7099	Intermediate Similarity	NPD3144	Approved
0.7099	Intermediate Similarity	NPD3145	Approved
0.7099	Intermediate Similarity	NPD597	Approved
0.7097	Intermediate Similarity	NPD1357	Approved
0.7087	Intermediate Similarity	NPD2983	Phase 2
0.7087	Intermediate Similarity	NPD2982	Phase 2
0.7087	Intermediate Similarity	NPD4659	Approved
0.7083	Intermediate Similarity	NPD5535	Approved
0.7077	Intermediate Similarity	NPD2605	Approved
0.7077	Intermediate Similarity	NPD2606	Approved
0.7071	Intermediate Similarity	NPD7422	Clinical (unspecified phase)
0.7068	Intermediate Similarity	NPD274	Approved
0.7068	Intermediate Similarity	NPD275	Approved
0.7063	Intermediate Similarity	NPD1610	Phase 2
0.7054	Intermediate Similarity	NPD4624	Approved
0.705	Intermediate Similarity	NPD3845	Phase 1
0.7045	Intermediate Similarity	NPD259	Phase 1
0.7045	Intermediate Similarity	NPD6663	Approved
0.7045	Intermediate Similarity	NPD1136	Approved
0.7045	Intermediate Similarity	NPD1132	Approved
0.7045	Intermediate Similarity	NPD1130	Approved
0.7043	Intermediate Similarity	NPD9500	Approved
0.7043	Intermediate Similarity	NPD5700	Clinical (unspecified phase)
0.704	Intermediate Similarity	NPD4626	Approved
0.7031	Intermediate Similarity	NPD1283	Approved
0.7025	Intermediate Similarity	NPD495	Approved
0.7025	Intermediate Similarity	NPD498	Approved
0.7025	Intermediate Similarity	NPD496	Approved
0.7015	Intermediate Similarity	NPD823	Approved
0.7015	Intermediate Similarity	NPD817	Approved
0.7009	Intermediate Similarity	NPD968	Approved
0.7008	Intermediate Similarity	NPD2981	Phase 2
0.7	Intermediate Similarity	NPD3018	Phase 2
0.6992	Remote Similarity	NPD6346	Approved
0.6984	Remote Similarity	NPD3847	Discontinued
0.6977	Remote Similarity	NPD4104	Clinical (unspecified phase)
0.6977	Remote Similarity	NPD4103	Phase 2
0.6963	Remote Similarity	NPD6896	Approved
0.6963	Remote Similarity	NPD6895	Approved
0.696	Remote Similarity	NPD1651	Approved
0.6957	Remote Similarity	NPD3060	Approved
0.6953	Remote Similarity	NPD6583	Phase 3
0.6953	Remote Similarity	NPD6582	Phase 2
0.6953	Remote Similarity	NPD1669	Approved
0.6953	Remote Similarity	NPD4749	Approved
0.695	Remote Similarity	NPD3645	Discontinued
0.695	Remote Similarity	NPD4160	Clinical (unspecified phase)
0.6947	Remote Similarity	NPD3594	Approved
0.6947	Remote Similarity	NPD3595	Approved
0.6944	Remote Similarity	NPD9094	Approved
0.694	Remote Similarity	NPD5735	Approved
0.694	Remote Similarity	NPD6355	Discontinued
0.694	Remote Similarity	NPD555	Phase 2
0.6929	Remote Similarity	NPD3705	Approved
0.6929	Remote Similarity	NPD1201	Approved
0.6923	Remote Similarity	NPD1969	Clinical (unspecified phase)
0.6923	Remote Similarity	NPD1972	Approved
0.6923	Remote Similarity	NPD1973	Approved
0.6911	Remote Similarity	NPD709	Approved
0.6906	Remote Similarity	NPD4109	Clinical (unspecified phase)
0.6906	Remote Similarity	NPD6331	Phase 2
0.6906	Remote Similarity	NPD4110	Phase 3
0.6905	Remote Similarity	NPD6516	Phase 2
0.6905	Remote Similarity	NPD5846	Approved

Bioactivity similarity: Similar Natural Products in NPASS

Bioactivity similarity was calculated based on bioactivity descriptors of compounds. The bioactivity descriptors were calculated by a recently developed AI algorithm Chemical Checker (CC) [Nature Biotechnology, 38:1087–1096, 2020; Nature Communications, 12:3932, 2021], which evaluated bioactivity similarities at five levels:
☉ A: chemistry similarity;
☉ B: biological targets similarity;
☉ C: networks similarity;
☉ D: cell-based bioactivity similarity;
☉ E: similarity based on clinical data.

Those 5 categories of CC bioactivity descriptors were calculated and then subjected to manifold projection using UMAP algorithm, to project all NPs on a 2-Dimensional space. The current NP was highlighted with a small circle in the 2-D map. Below figures: left-to-right, A-to-E.

A: chemistry similarity

B: biological targets similarity

C: networks similarity

D: cell-based bioactivity similarity

E: similarity based on clinical data