Natural Product Target: Tyrosyl-DNA phosphodiesterase 1

Target ID:   NPT50
Target Name:   Tyrosyl-DNA phosphodiesterase 1
Target Type:   Individual Protein
Organism of Target:   Homo sapiens
Target External ID:   Uniprot_ID:[ Q9NUW8]

  Biological Activities of Natural Products against the Target

Natural Product ID Natural Product Name # Activity Records
NPC190945 Nifedipine 6
NPC470091 Stictic Acid 5
NPC68441 Gossypol 5
NPC178134 Ellagic Acid 4
NPC107009 Carmine 4
NPC169207 Norepinephrine 4
NPC169749 Myricetin 4
NPC50898 Apigenin 4
NPC215584 Elliptecine 4
NPC160900 (1E,6E)-1,7-Bis(4-Hydroxy-3-Methoxyphenyl)Hepta-1,6-Diene-3,5-Dione 3
NPC118522 L-Norepinephrine 3
NPC88923 Reserpine 3
NPC41717 Fusaric Acid 3
NPC145888 D-Dopa 3
NPC225710 Gallic Acid 3
NPC471614 Ketoconazole 3
NPC254847 Emodin 3
NPC257236 Rottlerin 3
NPC316574 Mesalamine 3
NPC281398 Tanshinone Iia 3
NPC294902 Caffeic Acid 3
NPC158179 Icosa-5,8,11,14-Tetraynoic Acid 3
NPC25581 3-(3,4-Dihydroxyphenyl)-2-[(E)-3-(3,4-Dihydroxyphenyl)Prop-2-Enoyl]Oxypropanoic Acid 2
NPC63370 Nicardipine Hydrochloride 2
NPC313449 Dequalinium 2
NPC327252 Isospaglumic Acid 2
NPC180006 Auraptene 2
NPC205034 4-[(E)-2-[(1R,4As,5R,6R,8Ar)-6-Hydroxy-5-(Hydroxymethyl)-5,8A-Dimethyl-2-Methylidene-3,4,4A,6,7,8-Hexahydro-1H-Naphthalen-1-Yl]Ethenyl]-2H-Furan-5-One 2
NPC233282 Benzyl Salicylate 2
NPC279121 Luteolin 2
NPC329161 Slazinic Acid 2
NPC304788 Benzoquinone 2
NPC36836 Nicardipine 2
NPC146422 Dopamine 2
NPC20791 Quercetin 2
NPC146703 Benzamide 2
NPC290550 Emodic Acid 2
NPC189314 Mercaptopurine 2
NPC315634 Methyl 6,18-Dimethoxy-17-(3,4,5-Trimethoxybenzoyl)Oxy-1,3,11,12,14,15,16,17,18,19,20,21-Dodecahydroyohimban-19-Carboxylate 2
NPC207428 Deoxyvasicinone 2
NPC290563 Erucic Acid 2
NPC236347 Epinephrine 2
NPC208793 Aspartic Acid 2
NPC181523 Fumarprotocetraric Acid 2
NPC109403 Daunorubicin 2
NPC262198 Salvinorin A 2
NPC321561 Methyldopa 2
NPC209389 Indigo 2
NPC238861 1,6,6-Trimethyl-2,7,8,9-Tetrahydro-1H-Naphtho[1,2-G][1]Benzofuran-10,11-Dione 2
NPC322457 (Z)-7-[(1S,5E)-5-[(E)-Oct-2-Enylidene]-4-Oxocyclopent-2-En-1-Yl]Hept-5-Enoic Acid 2
NPC227841 Hypericin 2
NPC149571 Raloxifene 2
NPC294548 Linolenic Acid 2
NPC240887 Norstictic Acid 2
NPC86477 Wedelolactone 2
NPC317237 Haematoxylin 2
NPC228932 (2R)-2-Azaniumyl-3-Sulfosulfanylpropanoate 2
NPC241498 Hispidulin 2
NPC115284 Fanchinin 2
NPC325734 Arachidonoyl Glycine 2
NPC317651 (2S,3S,4R,5R)-3,4,5,6-Tetrahydroxyoxane-2-Carboxylic Acid 2
NPC46565 Hinokitiol 1
NPC88043 Marein 1
NPC297186 2',4'-Dihydroxychalcone 1
NPC61477 Catechin 1
NPC10251 Dibutyl Phthalate 1
NPC243894 1,1,2,2-Tetrachloroethane 1
NPC176858 Biphenyl-4-Amine 1
NPC311343 Butenone 1
NPC118343 Benzyl Benzoate 1
NPC272614 L-Alanine 1
NPC204617 2,4-Dichlorophenoxyacetic Acid 1
NPC318777 Oxidopamine 1
NPC326808 Cysteine 1
NPC73492 Cepharanthine 1
NPC216318 5,6,7,8-Tetrahydroxy-2-(4-Hydroxyphenyl)Chromen-4-One 1
NPC142638 Diotyrosine 1
NPC286989 Dexfosfoserine 1
NPC284810 Daphnorin 1
NPC88121 Chinomethionat 1
NPC231772 Acacetin 1
NPC161593 Levodopa 1
NPC298093 Rotenone 1
NPC100079 Chelerythrine 1
NPC244293 Sumiki's Acid 1
NPC273037 Quisqualate 1
NPC204932 Catechol 1
NPC319797 1,2-Dibromoethane 1
NPC73738 Daphnetin 1
NPC216361 Morin 1
NPC143168 Embelin 1
NPC287795 Bilirubin 1
NPC152306 7-Acetoxycoumarin 1
NPC88803 [5,7-Dihydroxy-2-(3,4,5-Trihydroxyphenyl)-3,4-Dihydro-2H-Chromen-3-Yl] 3,4,5-Trihydroxybenzoate 1
NPC232924 n.a. 1
NPC161768 Butyl 2-(2,4-Dichlorophenoxy)Acetate 1
NPC299990 n.a. 1
NPC64872 (4As,6As,6Br,8R,10S,12Ar)-8,10-Dihydroxy-2,2,6A,6B,9,9,12A-Heptamethyl-1,3,4,5,6,6A,7,8,8A,10,11,12,13,14B-Tetradecahydropicene-4A-Carboxylic Acid 1
NPC100734 Methyl (1S,15R,17S,18S,19R,20R)-6,18-Dimethoxy-17-(3,4,5-Trimethoxybenzoyl)Oxy-1,3,11,12,14,15,16,17,18,19,20,21-Dodecahydroyohimban-19-Carboxylate 1
NPC247553 Umbelliferone 1
NPC313810 But-3-Yn-2-Yl N-(3-Chlorophenyl)Carbamate 1
NPC120066 Piperonal 1
NPC273758 Dibenzoylmethane 1
NPC319933 2,4-Dibromo-1-(2,4-Dibromophenoxy)Benzene 1
NPC41326 Coumestrol 1
NPC73765 Uridine Triphosphate 1
NPC217052 Cichoric Acid 1
NPC143402 Erythrosine 1
NPC288089 Rhein 1
NPC472859 n.a. 1
NPC233267 Diffractaic Acid 1
NPC162547 3-Methylsulfanylpropanal 1
NPC300798 Pterocarpin 1
NPC67250 Naphthalene-1,4,5-Triol 1
NPC100980 Phenol 1
NPC248573 Cis-Resveratrol 1
NPC189142 Galuteolin 1
NPC314222 5-(Methylamino)-2-[[(2S,3R,5R,8S,9S)-3,5,9-Trimethyl-2-[1-Oxo-1-(1H-Pyrrol-2-Yl)Propan-2-Yl]-1,7-Dioxaspiro[5.5]Undecan-8-Yl]Methyl]-1,3-Benzoxazole-4-Carboxylic Acid 1
NPC120719 4-Tert-Butylbenzene-1,2-Diol 1
NPC275960 Helenalin 1
NPC206737 Schisanhenol 1
NPC73855 Myricitrin 1
NPC22783 2-(4-Hydroxyphenyl)Chromen-4-One 1
NPC144381 Xanthurenate 1
NPC288240 [(3Ar,4S,6Z,9E,11S,11Ar)-11-Hydroxy-6,10-Dimethyl-3-Methylidene-2,8-Dioxo-4,5,11,11A-Tetrahydro-3Ah-Cyclodeca[B]Furan-4-Yl] 2-Methylprop-2-Enoate 1
NPC471785 Sid11111800 1
NPC1502 Propionaldehyde 1
NPC164697 (-)-Usnic Acid 1
NPC301585 Myristic Acid 1
NPC67585 4-Methoxydalbergione 1
NPC103540 Danthron 1
NPC250436 Epigalocatechin Gallate 1
NPC189588 Digoxigenin 1
NPC314278 4-Nitrobenzoic Acid 1
NPC13470 Cephalexin 1
NPC278175 (Z)-1-[6-[(3-Acetyl-2,4,6-Trihydroxy-5-Methylphenyl)Methyl]-5,7-Dihydroxy-2,2-Dimethylchromen-8-Yl]-3-Phenylprop-2-En-1-One 1
NPC213 Oxedrine 1
NPC328877 Phenothiazine 1
NPC73978 Phenylglyoxal 1
NPC225539 Furan 1
NPC288838 Arundine 1
NPC471778 Lavendustin C 1
NPC91495 Arachidonic Acid 1
NPC233791 2,5-Dimethylfuran 1
NPC165846 (3S,4S,5R,6R)-6-(Hydroxymethyl)Oxane-2,3,4,5-Tetrol 1
NPC302790 Aminacrine 1
NPC250999 Zinc;1-Oxidopyridine-2-Thione 1
NPC190461 n.a. 1
NPC314333 n.a. 1
NPC123814 Dihydrospingosine 1
NPC74881 Robinetin 1
NPC16031 Dopa 1
NPC289432 1,6-Dimethyl-1,2-Dihydronaphtho[1,2-G][1]Benzofuran-10,11-Dione 1
NPC92403 Sennoside B 1
NPC234560 Daidzein 1
NPC166287 Lipoic Acid 1
NPC108218 Phenylethyl Alcohol 1
NPC254659 Homobutein 1
NPC320287 Permethrin 1
NPC125039 Silibinin 1
NPC280026 Lithocholic Acid 1
NPC329165 Monophosphothiamine 1
NPC77000 Cryptotanshinone 1
NPC226066 Retinyl Acetate 1
NPC289774 Isovitexin 1
NPC192674 9-Aminocamptothecin 1
NPC93241 Tanshinone I 1
NPC234956 Phenothrin 1
NPC304836 2-Nitroethanol 1
NPC108288 Juglone 1
NPC315403 Sulfanilamide 1
NPC321030 (7Z,10Z,13Z,16Z)-N-(2-Hydroxyethyl)Docosa-7,10,13,16-Tetraenamide 1
NPC61 Rosmarinic Acid 1
NPC280135 2-Methylnaphthalene 1
NPC329203 5-Hydroxy-2-(4-Hydroxyphenyl)-7-Methoxy-2,3-Dihydrochromen-4-One 1
NPC7839 n.a. 1
NPC226226 (2E,7S,10E,12R,13R,15S)-12,15-Dihydroxy-7-Methyl-8-Oxabicyclo[11.3.0]Hexadeca-2,10-Dien-9-One 1
NPC94167 Riboflavin 1
NPC235190 Umbelliprenin 1
NPC169591 Bavachinin A 1
NPC306074 2-Tert-Butylphenol 1
NPC108434 (1S)-1-[[4-[2-Hydroxy-5-[[(1S)-7-Hydroxy-6-Methoxy-1,2,3,4-Tetrahydroisoquinolin-1-Yl]Methyl]Phenoxy]Phenyl]Methyl]-6-Methoxy-1,2,3,4-Tetrahydroisoquinolin-7-Ol 1
NPC256838 3-Aminophenol 1
NPC191104 Bergamottin 1
NPC40209 1-Tert-Butyl-2-Methoxy-4-Methyl-3,5-Dinitrobenzene 1
NPC13696 5-[(S)-Amino(Carboxy)Methyl]-2-Hydroxybenzoic Acid 1
NPC280254 Pyrogallol 1
NPC83987 Pyridine 1
NPC226712 Salicin 1
NPC147212 Pentan-3-One 1
NPC988 Dihydrotanshinone I 1
NPC94298 Propylparaben 1
NPC307123 Atenolol 1
NPC109083 Curcumin 1
NPC191444 Benzidine 1
NPC316052 Erbstatin 1
NPC321402 (8R,9S,13S,14S,17S)-13-Methyl-6,7,8,9,11,12,14,15,16,17-Decahydrocyclopenta[A]Phenanthrene-2,3,17-Triol 1
NPC129533 n.a. 1
NPC281020 Homovanillic Acid 1
NPC3531 Valproic Acid 1
NPC84478 Harmaline 1
NPC227396 Prostaglandin B1 1
NPC147418 Quinalizarin 1
NPC34046 Chenodiol 1
NPC95162 Fraxetin 1
NPC238629 Purpurin 1
NPC170812 Scandenin 1
NPC307594 Methyl Isobutyl Ketone 1
NPC195763 Koparin 1
NPC4665 3,4-Dihydroxyphenylacetic Acid 1
NPC131214 2,2-Dimethylbutane 1
NPC471603 Sb-202190 1
NPC85443 Dipicolinic Acid 1
NPC24019 Oxoglaucine 1
NPC147983 Folic Acid 1
NPC293093 Hernandezine 1
NPC95412 Antimycin A 1
NPC172925 2-Naphthalen-1-Ylacetic Acid 1
NPC307963 Melatonin 1
NPC112336 Lavendustin A 1
NPC263386 Caffeic Acid Phenethyl Ester 1
NPC196449 Calcimycin 1
NPC317145 n.a. 1
NPC209970 Stearic Acid 1
NPC131530 Hispidin 1
NPC281986 Retinal 1
NPC44328 5-Hydroxy-2-(3-Hydroxy-4-Methoxyphenyl)-7-[3,4,5-Trihydroxy-6-[(3,4,5-Trihydroxy-6-Methyloxan-2-Yl)Oxymethyl]Oxan-2-Yl]Oxy-2,3-Dihydrochromen-4-One 1
NPC85813 Linoleic Acid 1
NPC293799 Gs-39783 1
NPC151113 Demethylencecalin 1
NPC472860 n.a. 1
NPC96835 Phenanthrene 1
NPC173991 4-Methylbenzene-1,2-Diamine 1
NPC308301 Bis(2-Ethylhexyl) Hexanedioate 1
NPC114270 Propylene Glycol 1
NPC264145 Gallic Acid Methyl Ester 1
NPC199851 Tetrahydroalstonine 1
NPC39426 Genistein 1
NPC40702 n.a. 1
NPC69057 (E)-1,4-Bis(4-Methylphenyl)But-2-Ene-1,4-Dione 1
NPC211453 Butanone 1
NPC135784 Aurin 1
NPC282923 Chrysophanol 1
NPC44530 Hematoxylin 1
NPC228343 Nordihydroguaiaretic Acid 1
NPC8235 P-Xylene 1
NPC228515 Butachlor 1
NPC153783 Orsellinic Acid, Ethyl Ester 1
NPC53545 Isoorientin 1
NPC97260 Actein 1
NPC241392 (2R)-4-(2-Amino-3-Hydroxyphenyl)-2-Azaniumyl-4-Oxobutanoate 1
NPC174048 2,5-Dichlorophenol 1
NPC309367 Thiram 1
NPC114682 3-Hydroxy-1-(4-Hydroxyphenyl)Propan-1-One 1
NPC264166 Quinidine 1
NPC200845 Ethyl (9E,12E,15E)-Octadeca-9,12,15-Trienoate 1
NPC323775 Racepinephrine 1
NPC69277 2-Mercaptobenzothiazole 1
NPC212415 Beta-Lapachone 1
NPC137847 (2E)-2-Benzylideneoctanal 1
NPC32441 Naringenin 1
NPC476454 Epibatidine 1
NPC45613 Phthalic Anhydride 1
NPC87043 n.a. 1
NPC157944 Asaraldehyde 1
NPC295531 Oxytetracycline 1
NPC56072 Bromobenzene 1
NPC97577 Lovastatin 1
NPC176127 n.a. 1
NPC310259 Pentamethylquercetin 1
NPC265605 R-Nicotine 1
NPC203719 Vanillin 1
NPC317400 Tolbutamide 1
NPC5989 Phorbol Myristate Acetate 1
NPC139891 Coumarin 1
NPC285829 Plumbagin 1
NPC45618 5,6-Dihydroxy-2-Phenyl-7-[(2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(Hydroxymethyl)Oxan-2-Yl]Oxychromen-4-One 1
NPC87125 Rhamnetin 1
NPC231149 Daphnoretin 1
NPC34864 Piceatannol 1
NPC58956 6,10-Dimethyl-3-Methylidene-3A,4,5,8,9,11A-Hexahydrocyclodeca[B]Furan-2-One 1
NPC97870 Esatenolol 1
NPC242895 Phloretin 1
NPC176381 Neomycin 1
NPC311219 Aspirin 1
NPC116775 Kaempferol 1
NPC271642 Benzyl(Trimethyl)Azanium;Chloride 1
NPC204210 2,4-Dimethylphenol 1
NPC326447 Octinoxate 1
NPC72980 Harmalol 1
NPC216092 9-[(2E)-3,7-Dimethylocta-2,6-Dienoxy]Furo[3,2-G]Chromen-7-One 1
NPC142330 Urea 1
NPC286641 Iodoform 1

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3. Compound Information: compound related data of all natural products that have available activity against this target;
4. Species Source: species sources that all natural products that have available activity against this target derived from.

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