NPASS Compound

Structure

CID94428 OpenBabel06191715432D 35 42 0 0 1 0 0 0 0 0999 V2000 -1.3401 -0.1115 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -0.8148 -2.3170 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 2.3698 2.0790 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -2.6370 0.2264 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 2.3696 1.3157 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -2.3068 -0.2382 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 1.7093 2.4606 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -2.3998 0.7446 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 1.7090 0.9344 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -1.7394 -0.1845 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 0.3211 -0.1144 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -2.1618 2.5903 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 1.0482 2.0793 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -1.8323 0.7983 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -1.5949 2.0798 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 1.0480 1.3160 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -1.5021 0.3337 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 0.3873 0.3871 0.0000 C 0 0 2 0 0 0 0 0 0 0 0 0 -1.5951 1.3165 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -0.2734 2.0796 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -0.9343 2.4611 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -0.2735 1.3163 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -0.9346 0.9350 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -1.0928 3.2073 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -0.6336 -0.9428 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -0.5476 0.0001 0.0000 C 0 0 2 0 0 0 0 0 0 0 0 0 -0.1463 -0.3079 0.0000 C 0 0 2 0 0 0 0 0 0 0 0 0 -1.8514 3.2871 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 0.3874 0.9347 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 -0.9347 0.3874 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 -0.5572 3.8020 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 -1.4270 -0.8381 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 0.1598 -1.0474 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 -0.3275 -1.6822 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 -0.0000 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 1 26 1 0 0 0 0 2 34 1 0 0 0 0 3 5 2 0 0 0 0 3 7 1 0 0 0 0 4 6 2 0 0 0 0 4 8 1 0 0 0 0 5 9 1 0 0 0 0 6 10 1 0 0 0 0 7 13 2 0 0 0 0 8 14 2 0 0 0 0 9 16 2 0 0 0 0 10 17 2 0 0 0 0 11 27 1 0 0 0 0 12 15 1 0 0 0 0 12 28 1 0 0 0 0 13 16 1 0 0 0 0 13 20 1 0 0 0 0 14 17 1 0 0 0 0 14 19 1 0 0 0 0 15 19 2 0 0 0 0 15 21 1 0 0 0 0 16 29 1 0 0 0 0 17 30 1 0 0 0 0 18 11 1 1 0 0 0 18 29 1 0 0 0 0 18 35 1 0 0 0 0 19 23 1 0 0 0 0 20 21 2 0 0 0 0 20 22 1 0 0 0 0 21 24 1 0 0 0 0 22 23 2 0 0 0 0 22 29 1 0 0 0 0 23 30 1 0 0 0 0 24 28 2 0 0 0 0 24 31 1 0 0 0 0 25 27 1 0 0 0 0 25 32 2 0 0 0 0 25 34 1 0 0 0 0 26 27 1 1 0 0 0 26 30 1 0 0 0 0 26 35 1 0 0 0 0 27 33 1 1 0 0 0 M END $$$$

Physi-Chem Properties

Molecular Weight:	467.15
Volume:	455.037
LogP:	4.963
LogD:	3.612
LogS:	-7.086
# Rotatable Bonds:	2
TPSA:	94.72
# H-Bond Aceptor:	8
# H-Bond Donor:	2
# Rings:	8
# Heavy Atoms:	8

MedChem Properties

QED Drug-Likeness Score:	0.367
Synthetic Accessibility Score:	4.799
Fsp3:	0.259
Lipinski Rule-of-5:	Accepted
Pfizer Rule:	Accepted
GSK Rule:	Rejected
BMS Rule:	0
Golden Triangle Rule:	Accepted
Chelating Alert:	0
PAINS Alert:	0

ADMET Properties (ADMETlab2.0)

ADMET: Absorption

Caco-2 Permeability:	-5.339
MDCK Permeability:	1.0505106729397085e-05
Pgp-inhibitor:	0.013
Pgp-substrate:	0.148
Human Intestinal Absorption (HIA):	0.412
20% Bioavailability (F20%):	0.02
30% Bioavailability (F30%):	0.587

ADMET: Distribution

Blood-Brain-Barrier Penetration (BBB):	0.279
Plasma Protein Binding (PPB):	96.61027526855469%
Volume Distribution (VD):	0.472
Pgp-substrate:	1.0847152471542358%

ADMET: Metabolism

CYP1A2-inhibitor:	0.791
CYP1A2-substrate:	0.965
CYP2C19-inhibitor:	0.848
CYP2C19-substrate:	0.874
CYP2C9-inhibitor:	0.931
CYP2C9-substrate:	0.47
CYP2D6-inhibitor:	0.483
CYP2D6-substrate:	0.194
CYP3A4-inhibitor:	0.874
CYP3A4-substrate:	0.931

ADMET: Excretion

Clearance (CL):	8.249
Half-life (T1/2):	0.033

ADMET: Toxicity

hERG Blockers:	0.14
Human Hepatotoxicity (H-HT):	0.921
Drug-inuced Liver Injury (DILI):	0.957
AMES Toxicity:	0.958
Rat Oral Acute Toxicity:	0.115
Maximum Recommended Daily Dose:	0.981
Skin Sensitization:	0.551
Carcinogencity:	0.987
Eye Corrosion:	0.003
Eye Irritation:	0.013
Respiratory Toxicity:	0.771

Download Data

Data Type	Select
General Info & Identifiers & Properties
Structure MOL file
Source Organisms
Biological Activities
Similar NPs/Drugs

Natural Product: NPC94428

Natural Product ID:	NPC94428
*Common Name:**	K-252A
IUPAC Name:	n.a.
Synonyms:	K-252A
Standard InCHIKey:	KOZFSFOOLUUIGY-SOLYNIJKSA-N
Standard InCHI:	InChI=1S/C27H21N3O5/c1-26-27(33,25(32)34-2)11-18(35-26)29-16-9-5-3-7-13(16)20-21-15(12-28-24(21)31)19-14-8-4-6-10-17(14)30(26)23(19)22(20)29/h3-10,18,33H,11-12H2,1-2H3,(H,28,31)/t18-,26+,27+/m1/s1
SMILES:	C[C@]12[C@](C[C@H](n3c4ccccc4c4c5c(CN=C5O)c5c6ccccc6n1c5c34)O2)(C(=O)OC)O
Synthetic Gene Cluster:	BGC0000813;BGC0000814;
ChEMBL Identifier:	CHEMBL281948
PubChem CID:	3035817
Chemical Classification:**	CHEMONTID:0000000 [Organic compounds] [CHEMONTID:0000002] Organoheterocyclic compounds [CHEMONTID:0000211] Indoles and derivatives [CHEMONTID:0000210] Carbazoles [CHEMONTID:0001865] Pyrrolocarbazoles [CHEMONTID:0001866] Indolocarbazoles

*Note: the InCHIKey will be temporarily assigned as the "Common Name" if no IUPAC name or alternative short name is available.
**Note: the Chemical Classification was calculated by NPClassifier Version 1.5. Reference: PMID:34662515.

Species Source

Organism ID	Organism Name	Taxonomy Level	Family	SuperKingdom	Isolation Part	Collection Location	Collection Time	Reference
NPO30978	0cardiopsis sp. k-252a	Species	0cardiopsaceae	Bacteria	n.a.	n.a.	n.a.	PMID[3759657]

☑ Note for Reference:
In addition to directly collecting NP source organism data from primary literature (where reference will provided as NCBI PMID or DOI links), NPASS also integrated them from below databases:
☉ UNPD: Universal Natural Products Database [PMID: 23638153].
☉ StreptomeDB: a database of streptomycetes natural products [PMID: 33051671].
☉ TM-MC: a database of medicinal materials and chemical compounds in Northeast Asian traditional medicine [PMID: 26156871].
☉ TCM@Taiwan: a Traditional Chinese Medicine database [PMID: 21253603].
☉ TCMID: a Traditional Chinese Medicine database [PMID: 29106634].
☉ TCMSP: The traditional Chinese medicine systems pharmacology database and analysis platform [PMID: 24735618].
☉ HerDing: a herb recommendation system to treat diseases using genes and chemicals [PMID: 26980517].
☉ MetaboLights: a metabolomics database [PMID: 27010336].
☉ FooDB: a database of constituents, chemistry and biology of food species [www.foodb.ca].

NP Quantity Composition/Concentration

Organism ID	NP ID	Organism Material Preparation	Organism Part	NP Quantity (Standard)	NP Quantity (Minimum)	NP Quantity (Maximum)	Quantity Unit	Reference

☑ Note for Reference:
In addition to directly collecting NP quantitative data from primary literature (where reference will provided as NCBI PMID or DOI links), NPASS also integrated NP quantitative records for specific NP domains (e.g., NPS from foods or herbs) from domain-specific databases. These databases include:
☉ DUKE: Dr. Duke's Phytochemical and Ethnobotanical Databases.
☉ PHENOL EXPLORER: is the first comprehensive database on polyphenol content in foods [PMID: 24103452], its homepage can be accessed at here.
☉ FooDB: a database of constituents, chemistry and biology of food species [www.foodb.ca].

Biological Activity

Activity Type	# Activity
IC50	24
Kd	296
Ki	1
Others	477

Activity Type	# Activity
Individual Protein	681
Others	8
Protein Complex	26
Protein Family	8
SINGLE PROTEIN	75

Target ID	Target Type	Target Name	Target Organism	Activity Type	Activity Relation	Value	Unit	Reference
NPT3239	Individual Protein	Nerve growth factor receptor Trk-A	Homo sapiens	IC50	=	13.0	nM	PMID[530739]
NPT1478	Individual Protein	Vascular endothelial growth factor receptor 2	Homo sapiens	IC50	=	43.0	nM	PMID[530739]
NPT2626	Individual Protein	Myosin light chain kinase, smooth muscle	Homo sapiens	IC50	=	22.0	nM	PMID[530739]
NPT1722	Individual Protein	Choline acetylase	Rattus norvegicus	Control	<	120.0	%	PMID[530741]
NPT1722	Individual Protein	Choline acetylase	Rattus norvegicus	Control	=	186.0	%	PMID[530741]
NPT1722	Individual Protein	Choline acetylase	Rattus norvegicus	Control	=	148.0	%	PMID[530741]
NPT1722	Individual Protein	Choline acetylase	Rattus norvegicus	Control	=	325.0	%	PMID[530741]
NPT3239	Individual Protein	Nerve growth factor receptor Trk-A	Homo sapiens	IC50	=	2.4	nM	PMID[530741]
NPT2543	Individual Protein	cAMP-dependent protein kinase alpha-catalytic subunit	Oryctolagus cuniculus	IC50	=	0.016	nM	PMID[530741]
NPT3325	Individual Protein	Myosin light chain kinase, smooth muscle	Gallus gallus	IC50	=	0.02	nM	PMID[530741]
NPT3605	Individual Protein	Protein kinase C gamma	Rattus norvegicus	IC50	=	470.0	nM	PMID[530745]
NPT3239	Individual Protein	Nerve growth factor receptor Trk-A	Homo sapiens	IC50	=	13.0	nM	PMID[530746]
NPT1478	Individual Protein	Vascular endothelial growth factor receptor 2	Homo sapiens	IC50	=	43.0	nM	PMID[530746]
NPT2626	Individual Protein	Myosin light chain kinase, smooth muscle	Homo sapiens	Ki	=	20.0	nM	PMID[530747]
NPT3317	Individual Protein	Serine/threonine-protein kinase MARK1	Homo sapiens	Residual Activity	=	0.0	%	PMID[530748]
NPT3419	Individual Protein	Serine/threonine-protein kinase SRPK3	Homo sapiens	Residual Activity	=	11.0	%	PMID[530748]
NPT3284	Individual Protein	Serine/threonine-protein kinase NEK7	Homo sapiens	Residual Activity	=	103.0	%	PMID[530748]
NPT3214	Individual Protein	Tyrosine-protein kinase ABL2	Homo sapiens	Residual Activity	=	35.0	%	PMID[530748]
NPT1686	Individual Protein	Casein kinase I isoform gamma-3	Homo sapiens	Residual Activity	=	58.0	%	PMID[530748]
NPT3266	Individual Protein	Casein kinase I delta	Homo sapiens	Residual Activity	=	79.0	%	PMID[530748]
NPT1672	Individual Protein	CaM kinase I delta	Homo sapiens	Residual Activity	=	0.0	%	PMID[530748]
NPT1721	Individual Protein	Death-associated protein kinase 1	Homo sapiens	Residual Activity	=	48.0	%	PMID[530748]
NPT3218	Individual Protein	Ephrin type-A receptor 4	Homo sapiens	Residual Activity	=	43.0	%	PMID[530748]
NPT3219	Individual Protein	Ephrin type-A receptor 5	Homo sapiens	Residual Activity	=	66.0	%	PMID[530748]
NPT3227	Individual Protein	Fibroblast growth factor receptor 3	Homo sapiens	Residual Activity	=	2.0	%	PMID[530748]
NPT14	Individual Protein	Tyrosine-protein kinase FYN	Homo sapiens	Residual Activity	=	4.0	%	PMID[530748]
NPT14	Individual Protein	Tyrosine-protein kinase FYN	Homo sapiens	Residual Activity	=	0.0	%	PMID[530748]
NPT3205	Individual Protein	Tyrosine-protein kinase HCK	Homo sapiens	Residual Activity	=	1.0	%	PMID[530748]
NPT3205	Individual Protein	Tyrosine-protein kinase HCK	Homo sapiens	Residual Activity	=	4.0	%	PMID[530748]
NPT3207	Individual Protein	c-Jun N-terminal kinase 3	Homo sapiens	Residual Activity	=	-3.0	%	PMID[530748]
NPT3207	Individual Protein	c-Jun N-terminal kinase 3	Homo sapiens	Residual Activity	=	-1.0	%	PMID[530748]
NPT491	Individual Protein	Dual specificity mitogen-activated protein kinase kinase 1	Homo sapiens	Residual Activity	=	0.0	%	PMID[530748]
NPT3419	Individual Protein	Serine/threonine-protein kinase SRPK3	Homo sapiens	Residual Activity	=	2.0	%	PMID[530748]
NPT1711	Individual Protein	Serine/threonine-protein kinase MST1	Homo sapiens	Residual Activity	=	5.0	%	PMID[530748]
NPT3284	Individual Protein	Serine/threonine-protein kinase NEK7	Homo sapiens	Residual Activity	=	95.0	%	PMID[530748]
NPT3285	Individual Protein	Serine/threonine protein kinase NLK	Homo sapiens	Residual Activity	=	42.0	%	PMID[530748]
NPT1432	Individual Protein	Serine/threonine-protein kinase Aurora-A	Homo sapiens	Residual Activity	=	2.0	%	PMID[530748]
NPT1432	Individual Protein	Serine/threonine-protein kinase Aurora-A	Homo sapiens	Residual Activity	=	-1.0	%	PMID[530748]
NPT3266	Individual Protein	Casein kinase I delta	Homo sapiens	Residual Activity	=	37.0	%	PMID[530748]
NPT1721	Individual Protein	Death-associated protein kinase 1	Homo sapiens	Residual Activity	=	10.0	%	PMID[530748]
NPT3219	Individual Protein	Ephrin type-A receptor 5	Homo sapiens	Residual Activity	=	13.0	%	PMID[530748]
NPT3372	Individual Protein	Fibroblast growth factor receptor 4	Homo sapiens	Residual Activity	=	88.0	%	PMID[530748]
NPT3372	Individual Protein	Fibroblast growth factor receptor 4	Homo sapiens	Residual Activity	=	36.0	%	PMID[530748]
NPT3406	Individual Protein	Mitogen-activated protein kinase kinase kinase kinase 2	Homo sapiens	Residual Activity	=	0.0	%	PMID[530748]
NPT1438	Individual Protein	Insulin-like growth factor I receptor	Homo sapiens	Residual Activity	=	77.0	%	PMID[530748]
NPT1478	Individual Protein	Vascular endothelial growth factor receptor 2	Homo sapiens	Residual Activity	=	3.0	%	PMID[530748]
NPT3282	Individual Protein	Maternal embryonic leucine zipper kinase	Homo sapiens	Residual Activity	=	1.0	%	PMID[530748]
NPT1711	Individual Protein	Serine/threonine-protein kinase MST1	Homo sapiens	Residual Activity	=	1.0	%	PMID[530748]
NPT3285	Individual Protein	Serine/threonine protein kinase NLK	Homo sapiens	Residual Activity	=	10.0	%	PMID[530748]
NPT1433	Individual Protein	Serine/threonine-protein kinase Aurora-B	Homo sapiens	Residual Activity	=	0.0	%	PMID[530748]
NPT3236	Individual Protein	Death-associated protein kinase 2	Homo sapiens	Residual Activity	=	12.0	%	PMID[530748]
NPT3236	Individual Protein	Death-associated protein kinase 2	Homo sapiens	Residual Activity	=	-3.0	%	PMID[530748]
NPT3211	Individual Protein	Ephrin type-A receptor 7	Homo sapiens	Residual Activity	=	32.0	%	PMID[530748]
NPT3211	Individual Protein	Ephrin type-A receptor 7	Homo sapiens	Residual Activity	=	4.0	%	PMID[530748]
NPT3244	Individual Protein	Tyrosine-protein kinase FER	Homo sapiens	Residual Activity	=	2.0	%	PMID[530748]
NPT3406	Individual Protein	Mitogen-activated protein kinase kinase kinase kinase 2	Homo sapiens	Residual Activity	=	1.0	%	PMID[530748]
NPT3457	Individual Protein	G protein-coupled receptor kinase 5	Homo sapiens	Residual Activity	=	40.0	%	PMID[530748]
NPT1438	Individual Protein	Insulin-like growth factor I receptor	Homo sapiens	Residual Activity	=	14.0	%	PMID[530748]
NPT1438	Individual Protein	Insulin-like growth factor I receptor	Homo sapiens	Residual Activity	=	23.0	%	PMID[530748]
NPT2574	Individual Protein	Insulin receptor	Homo sapiens	Residual Activity	=	42.0	%	PMID[530748]
NPT1478	Individual Protein	Vascular endothelial growth factor receptor 2	Homo sapiens	Residual Activity	=	0.0	%	PMID[530748]
NPT3242	Individual Protein	LIM domain kinase 1	Homo sapiens	Residual Activity	=	6.0	%	PMID[530748]
NPT3282	Individual Protein	Maternal embryonic leucine zipper kinase	Homo sapiens	Residual Activity	=	-1.0	%	PMID[530748]
NPT3331	Individual Protein	Serine/threonine-protein kinase MST2	Homo sapiens	Residual Activity	=	2.0	%	PMID[530748]
NPT3331	Individual Protein	Serine/threonine-protein kinase MST2	Homo sapiens	Residual Activity	=	1.0	%	PMID[530748]
NPT1442	Individual Protein	Serine/threonine-protein kinase PAK 2	Homo sapiens	Residual Activity	=	19.0	%	PMID[530748]
NPT1442	Individual Protein	Serine/threonine-protein kinase PAK 2	Homo sapiens	Residual Activity	=	2.0	%	PMID[530748]
NPT3206	Individual Protein	Serine/threonine-protein kinase Aurora-C	Homo sapiens	Residual Activity	=	2.0	%	PMID[530748]
NPT3273	Individual Protein	Casein kinase II alpha (prime)	Homo sapiens	Residual Activity	=	108.0	%	PMID[530748]
NPT3336	Individual Protein	Serine/threonine-protein kinase DCLK2	Homo sapiens	Residual Activity	=	75.0	%	PMID[530748]
NPT3216	Individual Protein	Ephrin type-A receptor 8	Homo sapiens	Residual Activity	=	78.0	%	PMID[530748]
NPT3457	Individual Protein	G protein-coupled receptor kinase 5	Homo sapiens	Residual Activity	=	5.0	%	PMID[530748]
NPT2574	Individual Protein	Insulin receptor	Homo sapiens	Residual Activity	=	20.0	%	PMID[530748]
NPT3242	Individual Protein	LIM domain kinase 1	Homo sapiens	Residual Activity	=	3.0	%	PMID[530748]
NPT3381	Individual Protein	Misshapen-like kinase 1	Homo sapiens	Residual Activity	=	0.0	%	PMID[530748]
NPT3381	Individual Protein	Misshapen-like kinase 1	Homo sapiens	Residual Activity	=	1.0	%	PMID[530748]
NPT3332	Individual Protein	Serine/threonine-protein kinase 24	Homo sapiens	Residual Activity	=	14.0	%	PMID[530748]
NPT3247	Individual Protein	Serine/threonine-protein kinase PAK 3	Homo sapiens	Residual Activity	=	4.0	%	PMID[530748]
NPT3206	Individual Protein	Serine/threonine-protein kinase Aurora-C	Homo sapiens	Residual Activity	=	1.0	%	PMID[530748]
NPT3273	Individual Protein	Casein kinase II alpha (prime)	Homo sapiens	Residual Activity	=	90.0	%	PMID[530748]
NPT1682	Individual Protein	Dual specificity protein kinase CLK2	Homo sapiens	Residual Activity	=	1.0	%	PMID[530748]
NPT3336	Individual Protein	Serine/threonine-protein kinase DCLK2	Homo sapiens	Residual Activity	=	41.0	%	PMID[530748]
NPT3303	Individual Protein	Discoidin domain-containing receptor 2	Homo sapiens	Residual Activity	=	56.0	%	PMID[530748]
NPT3216	Individual Protein	Ephrin type-A receptor 8	Homo sapiens	Residual Activity	=	40.0	%	PMID[530748]
NPT3212	Individual Protein	Ephrin type-B receptor 1	Homo sapiens	Residual Activity	=	39.0	%	PMID[530748]
NPT4088	Individual Protein	G protein-coupled receptor kinase 6	Homo sapiens	Residual Activity	=	36.0	%	PMID[530748]
NPT4088	Individual Protein	G protein-coupled receptor kinase 6	Homo sapiens	Residual Activity	=	5.0	%	PMID[530748]
NPT2574	Individual Protein	Insulin receptor	Homo sapiens	Residual Activity	=	7.0	%	PMID[530748]
NPT2574	Individual Protein	Insulin receptor	Homo sapiens	Residual Activity	=	0.0	%	PMID[530748]
NPT3279	Individual Protein	Serine/threonine-protein kinase 11	Homo sapiens	Residual Activity	=	97.0	%	PMID[530748]
NPT3279	Individual Protein	Serine/threonine-protein kinase 11	Homo sapiens	Residual Activity	=	74.0	%	PMID[530748]
NPT1691	Individual Protein	Dual specificity mitogen-activated protein kinase kinase 6	Homo sapiens	Residual Activity	=	26.0	%	PMID[530748]
NPT3332	Individual Protein	Serine/threonine-protein kinase 24	Homo sapiens	Residual Activity	=	0.0	%	PMID[530748]
NPT3320	Individual Protein	Proto-oncogene tyrosine-protein kinase MER	Homo sapiens	Residual Activity	=	2.0	%	PMID[530748]
NPT3245	Individual Protein	Tyrosine kinase non-receptor protein 2	Homo sapiens	Residual Activity	=	0.0	%	PMID[530748]
NPT1659	Individual Protein	Tyrosine-protein kinase receptor UFO	Homo sapiens	Residual Activity	=	4.0	%	PMID[530748]
NPT1659	Individual Protein	Tyrosine-protein kinase receptor UFO	Homo sapiens	Residual Activity	=	-3.0	%	PMID[530748]
NPT1682	Individual Protein	Dual specificity protein kinase CLK2	Homo sapiens	Residual Activity	=	4.0	%	PMID[530748]
NPT3303	Individual Protein	Discoidin domain-containing receptor 2	Homo sapiens	Residual Activity	=	17.0	%	PMID[530748]
NPT3212	Individual Protein	Ephrin type-B receptor 1	Homo sapiens	Residual Activity	=	4.0	%	PMID[530748]
NPT3438	Individual Protein	G protein-coupled receptor kinase 7	Homo sapiens	Residual Activity	=	4.0	%	PMID[530748]
NPT3386	Individual Protein	Interleukin-1 receptor-associated kinase 1	Homo sapiens	Residual Activity	=	1.0	%	PMID[530748]
NPT1707	Individual Protein	Serine/threonine-protein kinase 10	Homo sapiens	Residual Activity	=	3.0	%	PMID[530748]
NPT1691	Individual Protein	Dual specificity mitogen-activated protein kinase kinase 6	Homo sapiens	Residual Activity	=	0.0	%	PMID[530748]
NPT3320	Individual Protein	Proto-oncogene tyrosine-protein kinase MER	Homo sapiens	Residual Activity	=	0.0	%	PMID[530748]
NPT1661	Individual Protein	ALK tyrosine kinase receptor	Homo sapiens	Residual Activity	=	10.0	%	PMID[530748]
NPT3215	Individual Protein	Tyrosine-protein kinase BRK	Homo sapiens	Residual Activity	=	19.0	%	PMID[530748]
NPT1683	Individual Protein	Dual specificity protein kinase CLK3	Homo sapiens	Residual Activity	=	72.0	%	PMID[530748]
NPT1683	Individual Protein	Dual specificity protein kinase CLK3	Homo sapiens	Residual Activity	=	33.0	%	PMID[530748]
NPT1688	Individual Protein	Myotonin-protein kinase	Homo sapiens	Residual Activity	=	116.0	%	PMID[530748]
NPT1688	Individual Protein	Myotonin-protein kinase	Homo sapiens	Residual Activity	=	65.0	%	PMID[530748]
NPT2941	Individual Protein	Ephrin type-B receptor 2	Homo sapiens	Residual Activity	=	114.0	%	PMID[530748]
NPT2941	Individual Protein	Ephrin type-B receptor 2	Homo sapiens	Residual Activity	=	55.0	%	PMID[530748]
NPT3386	Individual Protein	Interleukin-1 receptor-associated kinase 1	Homo sapiens	Residual Activity	=	0.0	%	PMID[530748]
NPT3425	Individual Protein	Interleukin-1 receptor-associated kinase 4	Homo sapiens	Residual Activity	=	-2.0	%	PMID[530748]
NPT1707	Individual Protein	Serine/threonine-protein kinase 10	Homo sapiens	Residual Activity	=	1.0	%	PMID[530748]
NPT13	Individual Protein	Tyrosine-protein kinase LCK	Homo sapiens	Residual Activity	=	2.0	%	PMID[530748]
NPT3441	Individual Protein	Dual specificity mitogen-activated protein kinase kinase 7	Homo sapiens	Residual Activity	=	7.0	%	PMID[530748]
NPT3441	Individual Protein	Dual specificity mitogen-activated protein kinase kinase 7	Homo sapiens	Residual Activity	=	0.0	%	PMID[530748]
NPT1337	Individual Protein	Hepatocyte growth factor receptor	Homo sapiens	Residual Activity	=	6.0	%	PMID[530748]
NPT1337	Individual Protein	Hepatocyte growth factor receptor	Homo sapiens	Residual Activity	=	13.0	%	PMID[530748]
NPT1661	Individual Protein	ALK tyrosine kinase receptor	Homo sapiens	Residual Activity	=	1.0	%	PMID[530748]
NPT3215	Individual Protein	Tyrosine-protein kinase BRK	Homo sapiens	Residual Activity	=	1.0	%	PMID[530748]
NPT3113	Individual Protein	Tyrosine-protein kinase CSK	Homo sapiens	Residual Activity	=	71.0	%	PMID[530748]
NPT1709	Individual Protein	Serine/threonine-protein kinase 17A	Homo sapiens	Residual Activity	=	0.0	%	PMID[530748]
NPT3359	Individual Protein	Ephrin type-B receptor 3	Homo sapiens	Residual Activity	=	110.0	%	PMID[530748]
NPT3244	Individual Protein	Tyrosine-protein kinase FER	Homo sapiens	Residual Activity	=	0.0	%	PMID[530748]
NPT3425	Individual Protein	Interleukin-1 receptor-associated kinase 4	Homo sapiens	Residual Activity	=	0.0	%	PMID[530748]
NPT13	Individual Protein	Tyrosine-protein kinase LCK	Homo sapiens	Residual Activity	=	9.0	%	PMID[530748]
NPT2626	Individual Protein	Myosin light chain kinase, smooth muscle	Homo sapiens	Residual Activity	=	1.0	%	PMID[530748]
NPT3213	Individual Protein	MAP kinase signal-integrating kinase 2	Homo sapiens	Residual Activity	=	0.0	%	PMID[530748]
NPT3293	Individual Protein	Activin receptor type-1B	Homo sapiens	Residual Activity	=	24.0	%	PMID[530748]
NPT3293	Individual Protein	Activin receptor type-1B	Homo sapiens	Residual Activity	=	0.0	%	PMID[530748]
NPT3113	Individual Protein	Tyrosine-protein kinase CSK	Homo sapiens	Residual Activity	=	18.0	%	PMID[530748]
NPT3232	Individual Protein	CaM kinase I alpha	Homo sapiens	Residual Activity	=	6.0	%	PMID[530748]
NPT1709	Individual Protein	Serine/threonine-protein kinase 17A	Homo sapiens	Residual Activity	=	1.0	%	PMID[530748]
NPT3399	Individual Protein	Dual-specificity tyrosine-phosphorylation regulated kinase 2	Homo sapiens	Residual Activity	=	2.0	%	PMID[530748]
NPT3359	Individual Protein	Ephrin type-B receptor 3	Homo sapiens	Residual Activity	=	100.0	%	PMID[530748]
NPT1437	Individual Protein	Tyrosine-protein kinase FES	Homo sapiens	Residual Activity	=	7.0	%	PMID[530748]
NPT1437	Individual Protein	Tyrosine-protein kinase FES	Homo sapiens	Residual Activity	=	1.0	%	PMID[530748]
NPT591	Individual Protein	Glycogen synthase kinase-3 beta	Homo sapiens	Residual Activity	=	29.0	%	PMID[530748]
NPT591	Individual Protein	Glycogen synthase kinase-3 beta	Homo sapiens	Residual Activity	=	10.0	%	PMID[530748]
NPT3286	Individual Protein	Insulin receptor-related protein	Homo sapiens	Residual Activity	=	6.0	%	PMID[530748]
NPT3286	Individual Protein	Insulin receptor-related protein	Homo sapiens	Residual Activity	=	1.0	%	PMID[530748]
NPT13	Individual Protein	Tyrosine-protein kinase LCK	Homo sapiens	Residual Activity	=	6.0	%	PMID[530748]
NPT13	Individual Protein	Tyrosine-protein kinase LCK	Homo sapiens	Residual Activity	=	8.0	%	PMID[530748]
NPT2626	Individual Protein	Myosin light chain kinase, smooth muscle	Homo sapiens	Residual Activity	=	2.0	%	PMID[530748]
NPT3326	Individual Protein	Mitogen-activated protein kinase kinase kinase 9	Homo sapiens	Residual Activity	=	1.0	%	PMID[530748]
NPT3333	Individual Protein	Muscle, skeletal receptor tyrosine protein kinase	Homo sapiens	Residual Activity	=	18.0	%	PMID[530748]
NPT3312	Individual Protein	Tyrosine-protein kinase BLK	Homo sapiens	Residual Activity	=	1.0	%	PMID[530748]
NPT3312	Individual Protein	Tyrosine-protein kinase BLK	Homo sapiens	Residual Activity	=	0.0	%	PMID[530748]
NPT3232	Individual Protein	CaM kinase I alpha	Homo sapiens	Residual Activity	=	1.0	%	PMID[530748]
NPT3399	Individual Protein	Dual-specificity tyrosine-phosphorylation regulated kinase 2	Homo sapiens	Residual Activity	=	-4.0	%	PMID[530748]
NPT2572	Individual Protein	Ephrin type-B receptor 4	Homo sapiens	Residual Activity	=	71.0	%	PMID[530748]
NPT2572	Individual Protein	Ephrin type-B receptor 4	Homo sapiens	Residual Activity	=	22.0	%	PMID[530748]
NPT3112	Individual Protein	Tyrosine-protein kinase FGR	Homo sapiens	Residual Activity	=	3.0	%	PMID[530748]
NPT3444	Individual Protein	Homeodomain-interacting protein kinase 1	Homo sapiens	Residual Activity	=	78.0	%	PMID[530748]
NPT1439	Individual Protein	Tyrosine-protein kinase ITK/TSK	Homo sapiens	Residual Activity	=	15.0	%	PMID[530748]
NPT3111	Individual Protein	Tyrosine-protein kinase Lyn	Homo sapiens	Residual Activity	=	3.0	%	PMID[530748]
NPT3326	Individual Protein	Mitogen-activated protein kinase kinase kinase 9	Homo sapiens	Residual Activity	=	0.0	%	PMID[530748]
NPT3333	Individual Protein	Muscle, skeletal receptor tyrosine protein kinase	Homo sapiens	Residual Activity	=	2.0	%	PMID[530748]
NPT2750	Individual Protein	Tyrosine-protein kinase BMX	Homo sapiens	Residual Activity	=	1.0	%	PMID[530748]
NPT1608	Individual Protein	Serine/threonine-protein kinase Chk1	Homo sapiens	Residual Activity	=	1.0	%	PMID[530748]
NPT1608	Individual Protein	Serine/threonine-protein kinase Chk1	Homo sapiens	Residual Activity	=	-1.0	%	PMID[530748]
NPT1630	Individual Protein	CaM kinase II beta	Homo sapiens	Residual Activity	=	0.0	%	PMID[530748]
NPT1630	Individual Protein	CaM kinase II beta	Homo sapiens	Residual Activity	=	-1.0	%	PMID[530748]
NPT285	Individual Protein	Epidermal growth factor receptor erbB1	Homo sapiens	Residual Activity	=	72.0	%	PMID[530748]
NPT285	Individual Protein	Epidermal growth factor receptor erbB1	Homo sapiens	Residual Activity	=	47.0	%	PMID[530748]
NPT1435	Individual Protein	Receptor protein-tyrosine kinase erbB-4	Homo sapiens	Residual Activity	=	64.0	%	PMID[530748]
NPT3112	Individual Protein	Tyrosine-protein kinase FGR	Homo sapiens	Residual Activity	=	-1.0	%	PMID[530748]
NPT301	Individual Protein	Vascular endothelial growth factor receptor 1	Homo sapiens	Residual Activity	=	0.0	%	PMID[530748]
NPT3444	Individual Protein	Homeodomain-interacting protein kinase 1	Homo sapiens	Residual Activity	=	15.0	%	PMID[530748]
NPT3432	Individual Protein	Homeodomain-interacting protein kinase 2	Homo sapiens	Residual Activity	=	22.0	%	PMID[530748]
NPT1439	Individual Protein	Tyrosine-protein kinase ITK/TSK	Homo sapiens	Residual Activity	=	1.0	%	PMID[530748]
NPT3246	Individual Protein	Tyrosine-protein kinase JAK2	Homo sapiens	Residual Activity	=	2.0	%	PMID[530748]
NPT3111	Individual Protein	Tyrosine-protein kinase Lyn	Homo sapiens	Residual Activity	=	0.0	%	PMID[530748]
NPT281	Individual Protein	MAP kinase ERK1	Homo sapiens	Residual Activity	=	10.0	%	PMID[530748]
NPT3329	Individual Protein	Serine/threonine-protein kinase MRCK-A	Homo sapiens	Residual Activity	=	71.0	%	PMID[530748]
NPT3329	Individual Protein	Serine/threonine-protein kinase MRCK-A	Homo sapiens	Residual Activity	=	23.0	%	PMID[530748]
NPT3443	Individual Protein	Serine/threonine-protein kinase Nek11	Homo sapiens	Residual Activity	=	34.0	%	PMID[530748]
NPT3443	Individual Protein	Serine/threonine-protein kinase Nek11	Homo sapiens	Residual Activity	=	9.0	%	PMID[530748]
NPT1660	Individual Protein	NUAK family SNF1-like kinase 1	Homo sapiens	Residual Activity	=	1.0	%	PMID[530748]
NPT2750	Individual Protein	Tyrosine-protein kinase BMX	Homo sapiens	Residual Activity	=	2.0	%	PMID[530748]
NPT3315	Individual Protein	BR serine/threonine-protein kinase 1	Homo sapiens	Residual Activity	=	-1.0	%	PMID[530748]
NPT1680	Individual Protein	Serine/threonine-protein kinase Chk2	Homo sapiens	Residual Activity	=	3.0	%	PMID[530748]
NPT1676	Individual Protein	CaM kinase II gamma	Homo sapiens	Residual Activity	=	1.0	%	PMID[530748]
NPT3354	Individual Protein	Ephrin type-A receptor 1	Homo sapiens	Residual Activity	=	3.0	%	PMID[530748]
NPT1435	Individual Protein	Receptor protein-tyrosine kinase erbB-4	Homo sapiens	Residual Activity	=	19.0	%	PMID[530748]
NPT1436	Individual Protein	Focal adhesion kinase 1	Homo sapiens	Residual Activity	=	39.0	%	PMID[530748]
NPT3432	Individual Protein	Homeodomain-interacting protein kinase 2	Homo sapiens	Residual Activity	=	-1.0	%	PMID[530748]
NPT3246	Individual Protein	Tyrosine-protein kinase JAK2	Homo sapiens	Residual Activity	=	-1.0	%	PMID[530748]
NPT281	Individual Protein	MAP kinase ERK1	Homo sapiens	Residual Activity	=	-1.0	%	PMID[530748]
NPT3330	Individual Protein	Serine/threonine-protein kinase MRCK beta	Homo sapiens	Residual Activity	=	33.0	%	PMID[530748]
NPT1658	Individual Protein	Serine/threonine-protein kinase NEK2	Homo sapiens	Residual Activity	=	75.0	%	PMID[530748]
NPT3315	Individual Protein	BR serine/threonine-protein kinase 1	Homo sapiens	Residual Activity	=	0.0	%	PMID[530748]
NPT1680	Individual Protein	Serine/threonine-protein kinase Chk2	Homo sapiens	Residual Activity	=	1.0	%	PMID[530748]
NPT1684	Individual Protein	Casein kinase I gamma 1	Homo sapiens	Residual Activity	=	93.0	%	PMID[530748]
NPT1676	Individual Protein	CaM kinase II gamma	Homo sapiens	Residual Activity	=	0.0	%	PMID[530748]
NPT1675	Individual Protein	CaM kinase II delta	Homo sapiens	Residual Activity	=	0.0	%	PMID[530748]
NPT3354	Individual Protein	Ephrin type-A receptor 1	Homo sapiens	Residual Activity	=	0.0	%	PMID[530748]
NPT3225	Individual Protein	Ephrin type-A receptor 2	Homo sapiens	Residual Activity	=	44.0	%	PMID[530748]
NPT1436	Individual Protein	Focal adhesion kinase 1	Homo sapiens	Residual Activity	=	5.0	%	PMID[530748]
NPT1650	Individual Protein	Tyrosine-protein kinase receptor FLT3	Homo sapiens	Residual Activity	=	0.0	%	PMID[530748]
NPT1650	Individual Protein	Tyrosine-protein kinase receptor FLT3	Homo sapiens	Residual Activity	=	1.0	%	PMID[530748]
NPT3409	Individual Protein	Homeodomain-interacting protein kinase 3	Homo sapiens	Residual Activity	=	54.0	%	PMID[530748]
NPT3409	Individual Protein	Homeodomain-interacting protein kinase 3	Homo sapiens	Residual Activity	=	-4.0	%	PMID[530748]
NPT1440	Individual Protein	Tyrosine-protein kinase JAK3	Homo sapiens	Residual Activity	=	0.0	%	PMID[530748]
NPT282	Individual Protein	MAP kinase ERK2	Homo sapiens	Residual Activity	=	5.0	%	PMID[530748]
NPT282	Individual Protein	MAP kinase ERK2	Homo sapiens	Residual Activity	=	-3.0	%	PMID[530748]
NPT3330	Individual Protein	Serine/threonine-protein kinase MRCK beta	Homo sapiens	Residual Activity	=	5.0	%	PMID[530748]
NPT1613	Individual Protein	Ribosomal protein S6 kinase alpha 5	Homo sapiens	Residual Activity	=	5.0	%	PMID[530748]
NPT1658	Individual Protein	Serine/threonine-protein kinase NEK2	Homo sapiens	Residual Activity	=	29.0	%	PMID[530748]
NPT3391	Individual Protein	Serine/threonine-protein kinase Nek3	Homo sapiens	Residual Activity	=	65.0	%	PMID[530748]
NPT1431	Individual Protein	Mitogen-activated protein kinase kinase kinase 5	Homo sapiens	Residual Activity	=	0.0	%	PMID[530748]
NPT3344	Individual Protein	BR serine/threonine-protein kinase 2	Homo sapiens	Residual Activity	=	1.0	%	PMID[530748]
NPT3344	Individual Protein	BR serine/threonine-protein kinase 2	Homo sapiens	Residual Activity	=	0.0	%	PMID[530748]
NPT1684	Individual Protein	Casein kinase I gamma 1	Homo sapiens	Residual Activity	=	57.0	%	PMID[530748]
NPT1675	Individual Protein	CaM kinase II delta	Homo sapiens	Residual Activity	=	1.0	%	PMID[530748]
NPT3225	Individual Protein	Ephrin type-A receptor 2	Homo sapiens	Residual Activity	=	8.0	%	PMID[530748]
NPT1480	Individual Protein	Fibroblast growth factor receptor 1	Homo sapiens	Residual Activity	=	10.0	%	PMID[530748]
NPT1480	Individual Protein	Fibroblast growth factor receptor 1	Homo sapiens	Residual Activity	=	11.0	%	PMID[530748]
NPT2573	Individual Protein	Vascular endothelial growth factor receptor 3	Homo sapiens	Residual Activity	=	0.0	%	PMID[530748]
NPT4093	Individual Protein	Serine/threonine-protein kinase haspin	Homo sapiens	Residual Activity	=	8.0	%	PMID[530748]
NPT1426	Individual Protein	c-Jun N-terminal kinase 1	Homo sapiens	Residual Activity	=	-12.0	%	PMID[530748]
NPT1441	Individual Protein	MAP kinase-activated protein kinase 2	Homo sapiens	Residual Activity	=	0.0	%	PMID[530748]
NPT1613	Individual Protein	Ribosomal protein S6 kinase alpha 5	Homo sapiens	Residual Activity	=	0.0	%	PMID[530748]
NPT3391	Individual Protein	Serine/threonine-protein kinase Nek3	Homo sapiens	Residual Activity	=	53.0	%	PMID[530748]
NPT2729	Individual Protein	Tyrosine-protein kinase ABL	Homo sapiens	Residual Activity	=	80.0	%	PMID[530748]
NPT1685	Individual Protein	Casein kinase I gamma 2	Homo sapiens	Residual Activity	=	101.0	%	PMID[530748]
NPT1685	Individual Protein	Casein kinase I gamma 2	Homo sapiens	Residual Activity	=	60.0	%	PMID[530748]
NPT1677	Individual Protein	CaM kinase IV	Homo sapiens	Residual Activity	=	24.0	%	PMID[530748]
NPT1677	Individual Protein	CaM kinase IV	Homo sapiens	Residual Activity	=	11.0	%	PMID[530748]
NPT3217	Individual Protein	Ephrin type-A receptor 3	Homo sapiens	Residual Activity	=	42.0	%	PMID[530748]
NPT3217	Individual Protein	Ephrin type-A receptor 3	Homo sapiens	Residual Activity	=	5.0	%	PMID[530748]
NPT1481	Individual Protein	Fibroblast growth factor receptor 2	Homo sapiens	Residual Activity	=	20.0	%	PMID[530748]
NPT2573	Individual Protein	Vascular endothelial growth factor receptor 3	Homo sapiens	Residual Activity	=	1.0	%	PMID[530748]
NPT3267	Individual Protein	Macrophage colony stimulating factor receptor	Homo sapiens	Residual Activity	=	2.0	%	PMID[530748]
NPT4093	Individual Protein	Serine/threonine-protein kinase haspin	Homo sapiens	Residual Activity	=	5.0	%	PMID[530748]
NPT3205	Individual Protein	Tyrosine-protein kinase HCK	Homo sapiens	Residual Activity	=	3.0	%	PMID[530748]
NPT1426	Individual Protein	c-Jun N-terminal kinase 1	Homo sapiens	Residual Activity	=	-20.0	%	PMID[530748]
NPT1427	Individual Protein	c-Jun N-terminal kinase 2	Homo sapiens	Residual Activity	=	5.0	%	PMID[530748]
NPT1441	Individual Protein	MAP kinase-activated protein kinase 2	Homo sapiens	Residual Activity	=	-6.0	%	PMID[530748]
NPT3461	Individual Protein	MAP kinase-activated protein kinase 3	Homo sapiens	Residual Activity	=	47.0	%	PMID[530748]
NPT3374	Individual Protein	Ribosomal protein S6 kinase alpha 4	Homo sapiens	Residual Activity	=	-1.0	%	PMID[530748]
NPT3374	Individual Protein	Ribosomal protein S6 kinase alpha 4	Homo sapiens	Residual Activity	=	0.0	%	PMID[530748]
NPT1657	Individual Protein	Serine/threonine-protein kinase NEK6	Homo sapiens	Residual Activity	=	104.0	%	PMID[530748]
NPT1657	Individual Protein	Serine/threonine-protein kinase NEK6	Homo sapiens	Residual Activity	=	120.0	%	PMID[530748]
NPT2729	Individual Protein	Tyrosine-protein kinase ABL	Homo sapiens	Residual Activity	=	51.0	%	PMID[530748]
NPT3214	Individual Protein	Tyrosine-protein kinase ABL2	Homo sapiens	Residual Activity	=	79.0	%	PMID[530748]
NPT1686	Individual Protein	Casein kinase I isoform gamma-3	Homo sapiens	Residual Activity	=	99.0	%	PMID[530748]
NPT1672	Individual Protein	CaM kinase I delta	Homo sapiens	Residual Activity	=	5.0	%	PMID[530748]
NPT3218	Individual Protein	Ephrin type-A receptor 4	Homo sapiens	Residual Activity	=	83.0	%	PMID[530748]
NPT1481	Individual Protein	Fibroblast growth factor receptor 2	Homo sapiens	Residual Activity	=	2.0	%	PMID[530748]
NPT3227	Individual Protein	Fibroblast growth factor receptor 3	Homo sapiens	Residual Activity	=	17.0	%	PMID[530748]
NPT3267	Individual Protein	Macrophage colony stimulating factor receptor	Homo sapiens	Residual Activity	=	1.0	%	PMID[530748]
NPT1438	Individual Protein	Insulin-like growth factor I receptor	Homo sapiens	Residual Activity	=	3.0	%	PMID[530748]
NPT1427	Individual Protein	c-Jun N-terminal kinase 2	Homo sapiens	Residual Activity	=	-11.0	%	PMID[530748]
NPT3461	Individual Protein	MAP kinase-activated protein kinase 3	Homo sapiens	Residual Activity	=	2.0	%	PMID[530748]
NPT1699	Individual Protein	3-phosphoinositide dependent protein kinase-1	Homo sapiens	Residual Activity	=	0.0	%	PMID[530748]
NPT1703	Individual Protein	cAMP-dependent protein kinase alpha-catalytic subunit	Homo sapiens	Residual Activity	=	7.0	%	PMID[530748]
NPT3124	Individual Protein	Protein kinase C eta	Homo sapiens	Residual Activity	=	7.0	%	PMID[530748]
NPT1700	Individual Protein	Serine/threonine-protein kinase PIM2	Homo sapiens	Residual Activity	=	-2.0	%	PMID[530748]
NPT3277	Individual Protein	Tyrosine-protein kinase receptor TYRO3	Homo sapiens	Residual Activity	=	2.0	%	PMID[530748]
NPT3349	Individual Protein	Serine/threonine-protein kinase SIK1	Homo sapiens	Residual Activity	=	0.0	%	PMID[530748]
NPT3269	Individual Protein	Serine/threonine-protein kinase tousled-like 2	Homo sapiens	Residual Activity	=	1.0	%	PMID[530748]
NPT3269	Individual Protein	Serine/threonine-protein kinase tousled-like 2	Homo sapiens	Residual Activity	=	0.0	%	PMID[530748]
NPT4094	Individual Protein	Serine/threonine-protein kinase WNK3	Homo sapiens	Residual Activity	=	70.0	%	PMID[530748]
NPT1703	Individual Protein	cAMP-dependent protein kinase alpha-catalytic subunit	Homo sapiens	Residual Activity	=	3.0	%	PMID[530748]
NPT1701	Individual Protein	Serine/threonine-protein kinase PIM3	Homo sapiens	Residual Activity	=	31.0	%	PMID[530748]
NPT1701	Individual Protein	Serine/threonine-protein kinase PIM3	Homo sapiens	Residual Activity	=	5.0	%	PMID[530748]
NPT3106	Individual Protein	Ribosomal protein S6 kinase alpha 1	Homo sapiens	Residual Activity	=	1.0	%	PMID[530748]
NPT3106	Individual Protein	Ribosomal protein S6 kinase alpha 1	Homo sapiens	Residual Activity	=	2.0	%	PMID[530748]
NPT3291	Individual Protein	Serine/threonine-protein kinase SRPK1	Homo sapiens	Residual Activity	=	67.0	%	PMID[530748]
NPT3299	Individual Protein	Testis-specific serine/threonine-protein kinase 1	Homo sapiens	Residual Activity	=	-1.0	%	PMID[530748]
NPT4094	Individual Protein	Serine/threonine-protein kinase WNK3	Homo sapiens	Residual Activity	=	8.0	%	PMID[530748]
NPT1663	Individual Protein	Tyrosine-protein kinase YES	Homo sapiens	Residual Activity	=	11.0	%	PMID[530748]
NPT3394	Individual Protein	Protein kinase C iota	Homo sapiens	Residual Activity	=	107.0	%	PMID[530748]
NPT3394	Individual Protein	Protein kinase C iota	Homo sapiens	Residual Activity	=	69.0	%	PMID[530748]
NPT1705	Individual Protein	Ribosomal protein S6 kinase alpha 3	Homo sapiens	Residual Activity	=	1.0	%	PMID[530748]
NPT3291	Individual Protein	Serine/threonine-protein kinase SRPK1	Homo sapiens	Residual Activity	=	14.0	%	PMID[530748]
NPT3292	Individual Protein	Serine/threonine-protein kinase SRPK2	Homo sapiens	Residual Activity	=	97.0	%	PMID[530748]
NPT3299	Individual Protein	Testis-specific serine/threonine-protein kinase 1	Homo sapiens	Residual Activity	=	0.0	%	PMID[530748]
NPT3462	Individual Protein	Testis-specific serine/threonine-protein kinase 2	Homo sapiens	Residual Activity	=	8.0	%	PMID[530748]
NPT1663	Individual Protein	Tyrosine-protein kinase YES	Homo sapiens	Residual Activity	=	1.0	%	PMID[530748]
NPT1430	Individual Protein	Serine/threonine-protein kinase AKT2	Homo sapiens	Residual Activity	=	67.0	%	PMID[530748]
NPT3364	Individual Protein	Protein kinase C mu	Homo sapiens	Residual Activity	=	1.0	%	PMID[530748]
NPT3358	Individual Protein	Serine/threonine-protein kinase PLK3	Homo sapiens	Residual Activity	=	90.0	%	PMID[530748]
NPT3234	Individual Protein	Ribosomal protein S6 kinase alpha 2	Homo sapiens	Residual Activity	=	0.0	%	PMID[530748]
NPT3292	Individual Protein	Serine/threonine-protein kinase SRPK2	Homo sapiens	Residual Activity	=	52.0	%	PMID[530748]
NPT3462	Individual Protein	Testis-specific serine/threonine-protein kinase 2	Homo sapiens	Residual Activity	=	0.0	%	PMID[530748]
NPT3259	Individual Protein	Tyrosine-protein kinase ZAP-70	Homo sapiens	Residual Activity	=	16.0	%	PMID[530748]
NPT3259	Individual Protein	Tyrosine-protein kinase ZAP-70	Homo sapiens	Residual Activity	=	2.0	%	PMID[530748]
NPT1430	Individual Protein	Serine/threonine-protein kinase AKT2	Homo sapiens	Residual Activity	=	22.0	%	PMID[530748]
NPT2546	Individual Protein	Serine/threonine-protein kinase AKT3	Homo sapiens	Residual Activity	=	11.0	%	PMID[530748]
NPT3364	Individual Protein	Protein kinase C mu	Homo sapiens	Residual Activity	=	0.0	%	PMID[530748]
NPT3358	Individual Protein	Serine/threonine-protein kinase PLK3	Homo sapiens	Residual Activity	=	54.0	%	PMID[530748]
NPT3234	Individual Protein	Ribosomal protein S6 kinase alpha 2	Homo sapiens	Residual Activity	=	1.0	%	PMID[530748]
NPT3296	Individual Protein	Serine/threonine-protein kinase 33	Homo sapiens	Residual Activity	=	7.0	%	PMID[530748]
NPT3296	Individual Protein	Serine/threonine-protein kinase 33	Homo sapiens	Residual Activity	=	0.0	%	PMID[530748]
NPT3351	Individual Protein	Tyrosine-protein kinase TEC	Homo sapiens	Residual Activity	=	3.0	%	PMID[530748]
NPT3351	Individual Protein	Tyrosine-protein kinase TEC	Homo sapiens	Residual Activity	=	2.0	%	PMID[530748]
NPT1687	Individual Protein	Death-associated protein kinase 3	Homo sapiens	Residual Activity	=	12.0	%	PMID[530748]
NPT3247	Individual Protein	Serine/threonine-protein kinase PAK 3	Homo sapiens	Residual Activity	=	3.0	%	PMID[530748]
NPT1695	Individual Protein	Serine/threonine-protein kinase PAK 4	Homo sapiens	Residual Activity	=	3.0	%	PMID[530748]
NPT2546	Individual Protein	Serine/threonine-protein kinase AKT3	Homo sapiens	Residual Activity	=	3.0	%	PMID[530748]
NPT3365	Individual Protein	Serine/threonine-protein kinase D2	Homo sapiens	Residual Activity	=	2.0	%	PMID[530748]
NPT3365	Individual Protein	Serine/threonine-protein kinase D2	Homo sapiens	Residual Activity	=	0.0	%	PMID[530748]
NPT3262	Individual Protein	Serine/threonine-protein kinase PRKX	Homo sapiens	Residual Activity	=	2.0	%	PMID[530748]
NPT3262	Individual Protein	Serine/threonine-protein kinase PRKX	Homo sapiens	Residual Activity	=	0.0	%	PMID[530748]
NPT3254	Individual Protein	Ribosomal protein S6 kinase alpha 6	Homo sapiens	Residual Activity	=	-2.0	%	PMID[530748]
NPT3254	Individual Protein	Ribosomal protein S6 kinase alpha 6	Homo sapiens	Residual Activity	=	3.0	%	PMID[530748]
NPT3414	Individual Protein	Serine/threonine-protein kinase PLK2	Homo sapiens	Residual Activity	=	72.0	%	PMID[530748]
NPT2576	Individual Protein	Tyrosine-protein kinase TIE-2	Homo sapiens	Residual Activity	=	20.0	%	PMID[530748]
NPT1687	Individual Protein	Death-associated protein kinase 3	Homo sapiens	Residual Activity	=	2.0	%	PMID[530748]
NPT1424	Individual Protein	Serine/threonine-protein kinase RAF	Homo sapiens	Residual Activity	=	78.0	%	PMID[530748]
NPT1695	Individual Protein	Serine/threonine-protein kinase PAK 4	Homo sapiens	Residual Activity	=	0.0	%	PMID[530748]
NPT182	Individual Protein	Protein kinase C alpha	Homo sapiens	Residual Activity	=	19.0	%	PMID[530748]
NPT182	Individual Protein	Protein kinase C alpha	Homo sapiens	Residual Activity	=	0.0	%	PMID[530748]
NPT3367	Individual Protein	cGMP-dependent protein kinase 1 beta	Homo sapiens	Residual Activity	=	10.0	%	PMID[530748]
NPT3263	Individual Protein	Protein tyrosine kinase 2 beta	Homo sapiens	Residual Activity	=	3.0	%	PMID[530748]
NPT283	Individual Protein	MAP kinase p38 alpha	Homo sapiens	Residual Activity	=	92.0	%	PMID[530748]
NPT3414	Individual Protein	Serine/threonine-protein kinase PLK2	Homo sapiens	Residual Activity	=	36.0	%	PMID[530748]
NPT1449	Individual Protein	Tyrosine-protein kinase SYK	Homo sapiens	Residual Activity	=	1.0	%	PMID[530748]
NPT2576	Individual Protein	Tyrosine-protein kinase TIE-2	Homo sapiens	Residual Activity	=	3.0	%	PMID[530748]
NPT3239	Individual Protein	Nerve growth factor receptor Trk-A	Homo sapiens	Residual Activity	=	0.0	%	PMID[530748]
NPT1424	Individual Protein	Serine/threonine-protein kinase RAF	Homo sapiens	Residual Activity	=	69.0	%	PMID[530748]
NPT1696	Individual Protein	Serine/threonine-protein kinase PAK7	Homo sapiens	Residual Activity	=	6.0	%	PMID[530748]
NPT1696	Individual Protein	Serine/threonine-protein kinase PAK7	Homo sapiens	Residual Activity	=	1.0	%	PMID[530748]
NPT3367	Individual Protein	cGMP-dependent protein kinase 1 beta	Homo sapiens	Residual Activity	=	1.0	%	PMID[530748]
NPT3367	Individual Protein	cGMP-dependent protein kinase 1 beta	Homo sapiens	Residual Activity	=	9.0	%	PMID[530748]
NPT3263	Individual Protein	Protein tyrosine kinase 2 beta	Homo sapiens	Residual Activity	=	-1.0	%	PMID[530748]
NPT1447	Individual Protein	Serine/threonine-protein kinase RIPK2	Homo sapiens	Residual Activity	=	5.0	%	PMID[530748]
NPT283	Individual Protein	MAP kinase p38 alpha	Homo sapiens	Residual Activity	=	67.0	%	PMID[530748]
NPT1616	Individual Protein	MAP kinase p38 beta	Homo sapiens	Residual Activity	=	77.0	%	PMID[530748]
NPT1449	Individual Protein	Tyrosine-protein kinase SYK	Homo sapiens	Residual Activity	=	2.0	%	PMID[530748]
NPT3239	Individual Protein	Nerve growth factor receptor Trk-A	Homo sapiens	Residual Activity	=	1.0	%	PMID[530748]
NPT1479	Individual Protein	Stem cell growth factor receptor	Homo sapiens	Residual Activity	=	76.0	%	PMID[530748]
NPT1479	Individual Protein	Stem cell growth factor receptor	Homo sapiens	Residual Activity	=	20.0	%	PMID[530748]
NPT1697	Individual Protein	Serine/threonine-protein kinase PAK6	Homo sapiens	Residual Activity	=	0.0	%	PMID[530748]
NPT3367	Individual Protein	cGMP-dependent protein kinase 1 beta	Homo sapiens	Residual Activity	=	2.0	%	PMID[530748]
NPT1447	Individual Protein	Serine/threonine-protein kinase RIPK2	Homo sapiens	Residual Activity	=	3.0	%	PMID[530748]
NPT1616	Individual Protein	MAP kinase p38 beta	Homo sapiens	Residual Activity	=	29.0	%	PMID[530748]
NPT3442	Individual Protein	Mitogen-activated protein kinase kinase kinase 7	Homo sapiens	Residual Activity	=	-1.0	%	PMID[530748]
NPT3442	Individual Protein	Mitogen-activated protein kinase kinase kinase 7	Homo sapiens	Residual Activity	=	-5.0	%	PMID[530748]
NPT3270	Individual Protein	Neurotrophic tyrosine kinase receptor type 2	Homo sapiens	Residual Activity	=	0.0	%	PMID[530748]
NPT36	Individual Protein	Tyrosine-protein kinase SRC	Homo sapiens	Residual Activity	=	35.0	%	PMID[530748]
NPT1697	Individual Protein	Serine/threonine-protein kinase PAK6	Homo sapiens	Residual Activity	=	-1.0	%	PMID[530748]
NPT1612	Individual Protein	MAP kinase-activated protein kinase 5	Homo sapiens	Residual Activity	=	19.0	%	PMID[530748]
NPT1612	Individual Protein	MAP kinase-activated protein kinase 5	Homo sapiens	Residual Activity	=	0.0	%	PMID[530748]
NPT592	Individual Protein	Rho-associated protein kinase 1	Homo sapiens	Residual Activity	=	50.0	%	PMID[530748]
NPT592	Individual Protein	Rho-associated protein kinase 1	Homo sapiens	Residual Activity	=	12.0	%	PMID[530748]
NPT1615	Individual Protein	MAP kinase p38 gamma	Homo sapiens	Residual Activity	=	23.0	%	PMID[530748]
NPT3431	Individual Protein	Serine/threonine-protein kinase TAO1	Homo sapiens	Residual Activity	=	5.0	%	PMID[530748]
NPT3272	Individual Protein	Tyrosine-protein kinase TXK	Homo sapiens	Residual Activity	=	35.0	%	PMID[530748]
NPT36	Individual Protein	Tyrosine-protein kinase SRC	Homo sapiens	Residual Activity	=	5.0	%	PMID[530748]
NPT1344	Individual Protein	Serine/threonine-protein kinase EEF2K	Homo sapiens	Residual Activity	=	124.0	%	PMID[530748]
NPT3235	Individual Protein	MAP/microtubule affinity-regulating kinase 2	Homo sapiens	Residual Activity	=	1.0	%	PMID[530748]
NPT3235	Individual Protein	MAP/microtubule affinity-regulating kinase 2	Homo sapiens	Residual Activity	=	-2.0	%	PMID[530748]
NPT3357	Individual Protein	Protein kinase N2	Homo sapiens	Residual Activity	=	1.0	%	PMID[530748]
NPT3107	Individual Protein	Rho-associated protein kinase 2	Homo sapiens	Residual Activity	=	15.0	%	PMID[530748]
NPT1615	Individual Protein	MAP kinase p38 gamma	Homo sapiens	Residual Activity	=	2.0	%	PMID[530748]
NPT1614	Individual Protein	MAP kinase p38 delta	Homo sapiens	Residual Activity	=	58.0	%	PMID[530748]
NPT3431	Individual Protein	Serine/threonine-protein kinase TAO1	Homo sapiens	Residual Activity	=	3.0	%	PMID[530748]
NPT3426	Individual Protein	Serine/threonine-protein kinase TAO2	Homo sapiens	Residual Activity	=	16.0	%	PMID[530748]
NPT3272	Individual Protein	Tyrosine-protein kinase TXK	Homo sapiens	Residual Activity	=	5.0	%	PMID[530748]
NPT3422	Individual Protein	Serine/threonine-protein kinase ULK2	Homo sapiens	Residual Activity	=	7.0	%	PMID[530748]
NPT1344	Individual Protein	Serine/threonine-protein kinase EEF2K	Homo sapiens	Residual Activity	=	115.0	%	PMID[530748]
NPT3454	Individual Protein	PAS domain-containing serine/threonine-protein kinase	Homo sapiens	Residual Activity	=	14.0	%	PMID[530748]
NPT3204	Individual Protein	Tyrosine-protein kinase FRK	Homo sapiens	Residual Activity	=	25.0	%	PMID[530748]
NPT3107	Individual Protein	Rho-associated protein kinase 2	Homo sapiens	Residual Activity	=	2.0	%	PMID[530748]
NPT3370	Individual Protein	Tyrosine-protein kinase receptor RET	Homo sapiens	Residual Activity	=	2.0	%	PMID[530748]
NPT1614	Individual Protein	MAP kinase p38 delta	Homo sapiens	Residual Activity	=	10.0	%	PMID[530748]
NPT3426	Individual Protein	Serine/threonine-protein kinase TAO2	Homo sapiens	Residual Activity	=	2.0	%	PMID[530748]
NPT3422	Individual Protein	Serine/threonine-protein kinase ULK2	Homo sapiens	Residual Activity	=	0.0	%	PMID[530748]
NPT3454	Individual Protein	PAS domain-containing serine/threonine-protein kinase	Homo sapiens	Residual Activity	=	4.0	%	PMID[530748]
NPT3020	Individual Protein	Platelet-derived growth factor receptor alpha	Homo sapiens	Residual Activity	=	32.0	%	PMID[530748]
NPT3204	Individual Protein	Tyrosine-protein kinase FRK	Homo sapiens	Residual Activity	=	6.0	%	PMID[530748]
NPT3370	Individual Protein	Tyrosine-protein kinase receptor RET	Homo sapiens	Residual Activity	=	1.0	%	PMID[530748]
NPT1448	Individual Protein	Serine/threonine-protein kinase Sgk1	Homo sapiens	Residual Activity	=	4.0	%	PMID[530748]
NPT1448	Individual Protein	Serine/threonine-protein kinase Sgk1	Homo sapiens	Residual Activity	=	1.0	%	PMID[530748]
NPT3427	Individual Protein	Serine/threonine-protein kinase TAO3	Homo sapiens	Residual Activity	=	10.0	%	PMID[530748]
NPT3427	Individual Protein	Serine/threonine-protein kinase TAO3	Homo sapiens	Residual Activity	=	3.0	%	PMID[530748]
NPT3382	Individual Protein	Serine/threonine-protein kinase ULK3	Homo sapiens	Residual Activity	=	0.0	%	PMID[530748]
NPT3382	Individual Protein	Serine/threonine-protein kinase ULK3	Homo sapiens	Residual Activity	=	1.0	%	PMID[530748]
NPT3020	Individual Protein	Platelet-derived growth factor receptor alpha	Homo sapiens	Residual Activity	=	8.0	%	PMID[530748]
NPT3223	Individual Protein	Phosphorylase kinase gamma subunit 2	Homo sapiens	Residual Activity	=	0.0	%	PMID[530748]
NPT3223	Individual Protein	Phosphorylase kinase gamma subunit 2	Homo sapiens	Residual Activity	=	1.0	%	PMID[530748]
NPT3390	Individual Protein	Macrophage-stimulating protein receptor	Homo sapiens	Residual Activity	=	33.0	%	PMID[530748]
NPT3390	Individual Protein	Macrophage-stimulating protein receptor	Homo sapiens	Residual Activity	=	3.0	%	PMID[530748]
NPT3456	Individual Protein	Serine/threonine-protein kinase Sgk2	Homo sapiens	Residual Activity	=	7.0	%	PMID[530748]
NPT3417	Individual Protein	Serine/threonine-protein kinase TBK1	Homo sapiens	Residual Activity	=	-1.0	%	PMID[530748]
NPT1715	Individual Protein	Serine/threonine-protein kinase VRK2	Homo sapiens	Residual Activity	=	100.0	%	PMID[530748]
NPT1611	Individual Protein	Ribosomal protein S6 kinase 1	Homo sapiens	Residual Activity	=	6.0	%	PMID[530748]
NPT2575	Individual Protein	Platelet-derived growth factor receptor beta	Homo sapiens	Residual Activity	=	46.0	%	PMID[530748]
NPT2575	Individual Protein	Platelet-derived growth factor receptor beta	Homo sapiens	Residual Activity	=	8.0	%	PMID[530748]
NPT3455	Individual Protein	Protein kinase C zeta	Homo sapiens	Residual Activity	=	52.0	%	PMID[530748]
NPT3455	Individual Protein	Protein kinase C zeta	Homo sapiens	Residual Activity	=	8.0	%	PMID[530748]
NPT1265	Individual Protein	Serine/threonine-protein kinase PIM1	Homo sapiens	Residual Activity	=	10.0	%	PMID[530748]
NPT3373	Individual Protein	Proto-oncogene tyrosine-protein kinase ROS	Homo sapiens	Residual Activity	=	21.0	%	PMID[530748]
NPT3456	Individual Protein	Serine/threonine-protein kinase Sgk2	Homo sapiens	Residual Activity	=	1.0	%	PMID[530748]
NPT3418	Individual Protein	Serine/threonine-protein kinase Sgk3	Homo sapiens	Residual Activity	=	47.0	%	PMID[530748]
NPT3417	Individual Protein	Serine/threonine-protein kinase TBK1	Homo sapiens	Residual Activity	=	3.0	%	PMID[530748]
NPT3353	Individual Protein	TGF-beta receptor type I	Homo sapiens	Residual Activity	=	49.0	%	PMID[530748]
NPT1715	Individual Protein	Serine/threonine-protein kinase VRK2	Homo sapiens	Residual Activity	=	101.0	%	PMID[530748]
NPT1611	Individual Protein	Ribosomal protein S6 kinase 1	Homo sapiens	Residual Activity	=	1.0	%	PMID[530748]
NPT1699	Individual Protein	3-phosphoinositide dependent protein kinase-1	Homo sapiens	Residual Activity	=	-1.0	%	PMID[530748]
NPT3124	Individual Protein	Protein kinase C eta	Homo sapiens	Residual Activity	=	36.0	%	PMID[530748]
NPT1265	Individual Protein	Serine/threonine-protein kinase PIM1	Homo sapiens	Residual Activity	=	1.0	%	PMID[530748]
NPT1700	Individual Protein	Serine/threonine-protein kinase PIM2	Homo sapiens	Residual Activity	=	2.0	%	PMID[530748]
NPT3373	Individual Protein	Proto-oncogene tyrosine-protein kinase ROS	Homo sapiens	Residual Activity	=	3.0	%	PMID[530748]
NPT3277	Individual Protein	Tyrosine-protein kinase receptor TYRO3	Homo sapiens	Residual Activity	=	6.0	%	PMID[530748]
NPT3418	Individual Protein	Serine/threonine-protein kinase Sgk3	Homo sapiens	Residual Activity	=	13.0	%	PMID[530748]
NPT3353	Individual Protein	TGF-beta receptor type I	Homo sapiens	Residual Activity	=	8.0	%	PMID[530748]
NPT4096	Individual Protein	Serine/threonine-protein kinase WNK2	Homo sapiens	Residual Activity	=	63.0	%	PMID[530748]
NPT4096	Individual Protein	Serine/threonine-protein kinase WNK2	Homo sapiens	Residual Activity	=	12.0	%	PMID[530748]
NPT3464	Individual Protein	Myelin transcription factor 1	Homo sapiens	Activity	<	5.0	%	PMID[530749]
NPT3228	Individual Protein	Adaptor-associated kinase	Homo sapiens	Kd	=	5.0	nM	PMID[530750]
NPT2729	Individual Protein	Tyrosine-protein kinase ABL	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT3214	Individual Protein	Tyrosine-protein kinase ABL2	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT6548	Individual Protein	Actin-related protein 2	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT3287	Individual Protein	Activin receptor type-1	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT3293	Individual Protein	Activin receptor type-1B	Homo sapiens	Kd	=	15258.0	nM	PMID[530750]
NPT3295	Individual Protein	Activin receptor type-2B	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT3305	Individual Protein	Chaperone activity of bc1 complex-like, mitochondrial	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT2603	Individual Protein	Adenosine kinase	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT4031	Individual Protein	G-protein coupled receptor kinase 2	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT1430	Individual Protein	Serine/threonine-protein kinase AKT2	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT2546	Individual Protein	Serine/threonine-protein kinase AKT3	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT1661	Individual Protein	ALK tyrosine kinase receptor	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT1432	Individual Protein	Serine/threonine-protein kinase Aurora-A	Homo sapiens	Kd	=	20.0	nM	PMID[530750]
NPT1433	Individual Protein	Serine/threonine-protein kinase Aurora-B	Homo sapiens	Kd	=	353.0	nM	PMID[530750]
NPT3210	Individual Protein	BMP-2-inducible protein kinase	Homo sapiens	Kd	=	90.0	nM	PMID[530750]
NPT3313	Individual Protein	Bone morphogenetic protein receptor type-1A	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT3385	Individual Protein	Bone morphogenetic protein receptor type-1B	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT3314	Individual Protein	Bone morphogenetic protein receptor type-2	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT1434	Individual Protein	Serine/threonine-protein kinase B-raf	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT1675	Individual Protein	CaM kinase II delta	Homo sapiens	Kd	=	190.0	nM	PMID[530750]
NPT1676	Individual Protein	CaM kinase II gamma	Homo sapiens	Kd	=	173.0	nM	PMID[530750]
NPT1677	Individual Protein	CaM kinase IV	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT1678	Individual Protein	CaM-kinase kinase beta	Homo sapiens	Kd	=	2277.0	nM	PMID[530750]
NPT3329	Individual Protein	Serine/threonine-protein kinase MRCK-A	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT3330	Individual Protein	Serine/threonine-protein kinase MRCK beta	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT3306	Individual Protein	Serine/threonine-protein kinase MRCK gamma	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT1423	Individual Protein	Cyclin-dependent kinase 1	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT3401	Individual Protein	Cyclin-dependent kinase 13	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT1698	Individual Protein	Serine/threonine-protein kinase PCTAIRE-1	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT3250	Individual Protein	Serine/threonine-protein kinase PCTAIRE-2	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT1371	Individual Protein	Cyclin-dependent kinase 2	Homo sapiens	Kd	=	101.0	nM	PMID[530750]
NPT3345	Individual Protein	Cyclin-dependent kinase 3	Homo sapiens	Kd	=	32.0	nM	PMID[530750]
NPT2213	Individual Protein	Cyclin-dependent kinase 4	Homo sapiens	Kd	=	14.0	nM	PMID[530750]
NPT3240	Individual Protein	Cyclin-dependent kinase 5	Homo sapiens	Kd	=	911.0	nM	PMID[530750]
NPT1571	Individual Protein	Cyclin-dependent kinase 6	Homo sapiens	Kd	=	399.0	nM	PMID[530750]
NPT3346	Individual Protein	Cyclin-dependent kinase 7	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT3347	Individual Protein	Cyclin-dependent kinase 9	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT3397	Individual Protein	Cyclin-dependent kinase-like 5	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT1608	Individual Protein	Serine/threonine-protein kinase Chk1	Homo sapiens	Kd	=	122.0	nM	PMID[530750]
NPT3334	Individual Protein	Citron Rho-interacting kinase	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT1681	Individual Protein	Dual specificty protein kinase CLK1	Homo sapiens	Kd	=	10.0	nM	PMID[530750]
NPT1682	Individual Protein	Dual specificity protein kinase CLK2	Homo sapiens	Kd	=	3809.0	nM	PMID[530750]
NPT3231	Individual Protein	Dual specificity protein kinase CLK4	Homo sapiens	Kd	=	15.0	nM	PMID[530750]
NPT3113	Individual Protein	Tyrosine-protein kinase CSK	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT3168	Individual Protein	Casein kinase I alpha	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT3266	Individual Protein	Casein kinase I delta	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT3226	Individual Protein	Casein kinase I epsilon	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT1684	Individual Protein	Casein kinase I gamma 1	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT1685	Individual Protein	Casein kinase I gamma 2	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT1686	Individual Protein	Casein kinase I isoform gamma-3	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT3273	Individual Protein	Casein kinase II alpha (prime)	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT3560	Individual Protein	Deoxycytidine kinase	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT5825	Individual Protein	dCTP pyrophosphatase 1	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT3342	Individual Protein	Epithelial discoidin domain-containing receptor 1	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT3303	Individual Protein	Discoidin domain-containing receptor 2	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT3114	Individual Protein	Dual-specificity tyrosine-phosphorylation regulated kinase 1A	Homo sapiens	Kd	=	4852.0	nM	PMID[530750]
NPT3274	Individual Protein	Dual specificity tyrosine-phosphorylation-regulated kinase 1B	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT285	Individual Protein	Epidermal growth factor receptor erbB1	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT3420	Individual Protein	Eukaryotic translation initiation factor 2-alpha kinase 1	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT3354	Individual Protein	Ephrin type-A receptor 1	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT3225	Individual Protein	Ephrin type-A receptor 2	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT3218	Individual Protein	Ephrin type-A receptor 4	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT3219	Individual Protein	Ephrin type-A receptor 5	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT3211	Individual Protein	Ephrin type-A receptor 7	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT2941	Individual Protein	Ephrin type-B receptor 2	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT3359	Individual Protein	Ephrin type-B receptor 3	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT2572	Individual Protein	Ephrin type-B receptor 4	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT3404	Individual Protein	Ephrin type-B receptor 6	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT1890	Individual Protein	Serine/threonine-protein kinase/endoribonuclease IRE1	Homo sapiens	Kd	=	19.0	nM	PMID[530750]
NPT3244	Individual Protein	Tyrosine-protein kinase FER	Homo sapiens	Kd	=	455.0	nM	PMID[530750]
NPT1437	Individual Protein	Tyrosine-protein kinase FES	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT1480	Individual Protein	Fibroblast growth factor receptor 1	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT1650	Individual Protein	Tyrosine-protein kinase receptor FLT3	Homo sapiens	Kd	=	227.0	nM	PMID[530750]
NPT3204	Individual Protein	Tyrosine-protein kinase FRK	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT14	Individual Protein	Tyrosine-protein kinase FYN	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT3221	Individual Protein	Serine/threonine-protein kinase GAK	Homo sapiens	Kd	=	1269.0	nM	PMID[530750]
NPT591	Individual Protein	Glycogen synthase kinase-3 beta	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT3205	Individual Protein	Tyrosine-protein kinase HCK	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT3423	Individual Protein	Serine/threonine-protein kinase ICK	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT1438	Individual Protein	Insulin-like growth factor I receptor	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT3275	Individual Protein	Inhibitor of nuclear factor kappa B kinase epsilon subunit	Homo sapiens	Kd	=	494.0	nM	PMID[530750]
NPT2817	Individual Protein	Inosine-5'-monophosphate dehydrogenase 2	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT2574	Individual Protein	Insulin receptor	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT3386	Individual Protein	Interleukin-1 receptor-associated kinase 1	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT3288	Individual Protein	Interleukin-1 receptor-associated kinase 3	Homo sapiens	Kd	=	254.0	nM	PMID[530750]
NPT3425	Individual Protein	Interleukin-1 receptor-associated kinase 4	Homo sapiens	Kd	=	9.0	nM	PMID[530750]
NPT1689	Individual Protein	Tyrosine-protein kinase JAK1	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT3307	Individual Protein	Serine/threonine-protein kinase LATS1	Homo sapiens	Kd	=	67.0	nM	PMID[530750]
NPT13	Individual Protein	Tyrosine-protein kinase LCK	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT3242	Individual Protein	LIM domain kinase 1	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT3278	Individual Protein	LIM domain kinase 2	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT3111	Individual Protein	Tyrosine-protein kinase Lyn	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT491	Individual Protein	Dual specificity mitogen-activated protein kinase kinase 1	Homo sapiens	Kd	=	1747.0	nM	PMID[530750]
NPT1690	Individual Protein	Dual specificity mitogen-activated protein kinase kinase 2	Homo sapiens	Kd	=	474.0	nM	PMID[530750]
NPT3281	Individual Protein	Dual specificity mitogen-activated protein kinase kinase 3	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT3319	Individual Protein	Dual specificity mitogen-activated protein kinase kinase 4	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT3440	Individual Protein	Dual specificity mitogen-activated protein kinase kinase 5	Homo sapiens	Kd	=	2033.0	nM	PMID[530750]
NPT1691	Individual Protein	Dual specificity mitogen-activated protein kinase kinase 6	Homo sapiens	Kd	=	88.0	nM	PMID[530750]
NPT3411	Individual Protein	Mitogen-activated protein kinase kinase kinase 1	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT3328	Individual Protein	Mitogen-activated protein kinase kinase kinase 11	Homo sapiens	Kd	=	572.0	nM	PMID[530750]
NPT3413	Individual Protein	Mitogen-activated protein kinase kinase kinase 2	Homo sapiens	Kd	=	4118.0	nM	PMID[530750]
NPT3389	Individual Protein	Mitogen-activated protein kinase kinase kinase 3	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT3209	Individual Protein	Mitogen-activated protein kinase kinase kinase 4	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT1431	Individual Protein	Mitogen-activated protein kinase kinase kinase 5	Homo sapiens	Kd	=	182.0	nM	PMID[530750]
NPT3407	Individual Protein	Mitogen-activated protein kinase kinase kinase 6	Homo sapiens	Kd	=	335.0	nM	PMID[530750]
NPT3310	Individual Protein	Mitogen-activated protein kinase kinase kinase kinase 1	Homo sapiens	Kd	=	452.0	nM	PMID[530750]
NPT3406	Individual Protein	Mitogen-activated protein kinase kinase kinase kinase 2	Homo sapiens	Kd	=	131.0	nM	PMID[530750]
NPT3311	Individual Protein	Mitogen-activated protein kinase kinase kinase kinase 3	Homo sapiens	Kd	=	2374.0	nM	PMID[530750]
NPT3316	Individual Protein	Mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	Kd	=	19.0	nM	PMID[530750]
NPT3109	Individual Protein	Mitogen-activated protein kinase kinase kinase kinase 5	Homo sapiens	Kd	=	193.0	nM	PMID[530750]
NPT282	Individual Protein	MAP kinase ERK2	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT3207	Individual Protein	c-Jun N-terminal kinase 3	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT1616	Individual Protein	MAP kinase p38 beta	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT283	Individual Protein	MAP kinase p38 alpha	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT3363	Individual Protein	Mitogen-activated protein kinase 15	Homo sapiens	Kd	=	167.0	nM	PMID[530750]
NPT281	Individual Protein	MAP kinase ERK1	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT3362	Individual Protein	Mitogen-activated protein kinase 7	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT1426	Individual Protein	c-Jun N-terminal kinase 1	Homo sapiens	Kd	=	551.0	nM	PMID[530750]
NPT1427	Individual Protein	c-Jun N-terminal kinase 2	Homo sapiens	Kd	=	986.0	nM	PMID[530750]
NPT1441	Individual Protein	MAP kinase-activated protein kinase 2	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT3461	Individual Protein	MAP kinase-activated protein kinase 3	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT1612	Individual Protein	MAP kinase-activated protein kinase 5	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT3235	Individual Protein	MAP/microtubule affinity-regulating kinase 2	Homo sapiens	Kd	=	704.0	nM	PMID[530750]
NPT3280	Individual Protein	Serine/threonine-protein kinase c-TAK1	Homo sapiens	Kd	=	384.0	nM	PMID[530750]
NPT3318	Individual Protein	MAP/microtubule affinity-regulating kinase 4	Homo sapiens	Kd	=	28.0	nM	PMID[530750]
NPT3282	Individual Protein	Maternal embryonic leucine zipper kinase	Homo sapiens	Kd	=	83.0	nM	PMID[530750]
NPT3320	Individual Protein	Proto-oncogene tyrosine-protein kinase MER	Homo sapiens	Kd	=	41.0	nM	PMID[530750]
NPT1337	Individual Protein	Hepatocyte growth factor receptor	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT3381	Individual Protein	Misshapen-like kinase 1	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT3390	Individual Protein	Macrophage-stimulating protein receptor	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT2626	Individual Protein	Myosin light chain kinase, smooth muscle	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT3446	Individual Protein	Myosin light chain kinase	Homo sapiens	Kd	=	98.0	nM	PMID[530750]
NPT3340	Individual Protein	Serine/threonine-protein kinase Nek1	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT1658	Individual Protein	Serine/threonine-protein kinase NEK2	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT3391	Individual Protein	Serine/threonine-protein kinase Nek3	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT3284	Individual Protein	Serine/threonine-protein kinase NEK7	Homo sapiens	Kd	=	3.0	nM	PMID[530750]
NPT3241	Individual Protein	Serine/threonine-protein kinase NEK9	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT3285	Individual Protein	Serine/threonine protein kinase NLK	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT366	Individual Protein	Quinone reductase 2	Homo sapiens	Kd	=	4031.0	nM	PMID[530750]
NPT3239	Individual Protein	Nerve growth factor receptor Trk-A	Homo sapiens	Kd	=	1739.0	nM	PMID[530750]
NPT3348	Individual Protein	NUAK family SNF1-like kinase 2	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT1442	Individual Protein	Serine/threonine-protein kinase PAK 2	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT1695	Individual Protein	Serine/threonine-protein kinase PAK 4	Homo sapiens	Kd	=	344.0	nM	PMID[530750]
NPT1697	Individual Protein	Serine/threonine-protein kinase PAK6	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT2575	Individual Protein	Platelet-derived growth factor receptor beta	Homo sapiens	Kd	=	1006.0	nM	PMID[530750]
NPT3223	Individual Protein	Phosphorylase kinase gamma subunit 2	Homo sapiens	Kd	=	3263.0	nM	PMID[530750]
NPT1265	Individual Protein	Serine/threonine-protein kinase PIM1	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT1700	Individual Protein	Serine/threonine-protein kinase PIM2	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT3433	Individual Protein	Phosphatidylinositol-5-phosphate 4-kinase type-2 gamma	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT3249	Individual Protein	Tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT1656	Individual Protein	Protein kinase N1	Homo sapiens	Kd	=	264.0	nM	PMID[530750]
NPT3357	Individual Protein	Protein kinase N2	Homo sapiens	Kd	=	361.0	nM	PMID[530750]
NPT1702	Individual Protein	Serine/threonine-protein kinase PLK4	Homo sapiens	Kd	=	73.0	nM	PMID[530750]
NPT3222	Individual Protein	AMP-activated protein kinase, alpha-1 subunit	Homo sapiens	Kd	=	461.0	nM	PMID[530750]
NPT1703	Individual Protein	cAMP-dependent protein kinase alpha-catalytic subunit	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT3261	Individual Protein	cAMP-dependent protein kinase beta-1 catalytic subunit	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT182	Individual Protein	Protein kinase C alpha	Homo sapiens	Kd	=	2280.0	nM	PMID[530750]
NPT3394	Individual Protein	Protein kinase C iota	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT3455	Individual Protein	Protein kinase C zeta	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT3365	Individual Protein	Serine/threonine-protein kinase D2	Homo sapiens	Kd	=	30.0	nM	PMID[530750]
NPT3366	Individual Protein	Protein kinase C nu	Homo sapiens	Kd	=	38.0	nM	PMID[530750]
NPT3367	Individual Protein	cGMP-dependent protein kinase 1 beta	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT1436	Individual Protein	Focal adhesion kinase 1	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT3263	Individual Protein	Protein tyrosine kinase 2 beta	Homo sapiens	Kd	=	1360.0	nM	PMID[530750]
NPT3215	Individual Protein	Tyrosine-protein kinase BRK	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT2824	Individual Protein	Brain glycogen phosphorylase	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT1667	Individual Protein	Liver glycogen phosphorylase	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT3370	Individual Protein	Tyrosine-protein kinase receptor RET	Homo sapiens	Kd	=	669.0	nM	PMID[530750]
NPT1447	Individual Protein	Serine/threonine-protein kinase RIPK2	Homo sapiens	Kd	=	526.0	nM	PMID[530750]
NPT592	Individual Protein	Rho-associated protein kinase 1	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT3107	Individual Protein	Rho-associated protein kinase 2	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT3106	Individual Protein	Ribosomal protein S6 kinase alpha 1	Homo sapiens	Kd	=	2994.0	nM	PMID[530750]
NPT1705	Individual Protein	Ribosomal protein S6 kinase alpha 3	Homo sapiens	Kd	=	2990.0	nM	PMID[530750]
NPT3374	Individual Protein	Ribosomal protein S6 kinase alpha 4	Homo sapiens	Kd	=	432.0	nM	PMID[530750]
NPT1613	Individual Protein	Ribosomal protein S6 kinase alpha 5	Homo sapiens	Kd	=	14659.0	nM	PMID[530750]
NPT3254	Individual Protein	Ribosomal protein S6 kinase alpha 6	Homo sapiens	Kd	=	2181.0	nM	PMID[530750]
NPT1611	Individual Protein	Ribosomal protein S6 kinase 1	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT3290	Individual Protein	Serine/threonine-protein kinase SIK2	Homo sapiens	Kd	=	58.0	nM	PMID[530750]
NPT3378	Individual Protein	Serine/threonine-protein kinase SIK3	Homo sapiens	Kd	=	4027.0	nM	PMID[530750]
NPT1706	Individual Protein	Serine/threonine-protein kinase 2	Homo sapiens	Kd	=	3305.0	nM	PMID[530750]
NPT36	Individual Protein	Tyrosine-protein kinase SRC	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT1707	Individual Protein	Serine/threonine-protein kinase 10	Homo sapiens	Kd	=	481.0	nM	PMID[530750]
NPT3279	Individual Protein	Serine/threonine-protein kinase 11	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT1708	Individual Protein	Serine/threonine-protein kinase 16	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT3332	Individual Protein	Serine/threonine-protein kinase 24	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT1693	Individual Protein	Serine/threonine-protein kinase MST4	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT3331	Individual Protein	Serine/threonine-protein kinase MST2	Homo sapiens	Kd	=	43.0	nM	PMID[530750]
NPT1710	Individual Protein	Serine/threonine-protein kinase 38	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT3233	Individual Protein	Serine/threonine-protein kinase 38-like	Homo sapiens	Kd	=	2137.0	nM	PMID[530750]
NPT1711	Individual Protein	Serine/threonine-protein kinase MST1	Homo sapiens	Kd	=	29.0	nM	PMID[530750]
NPT1449	Individual Protein	Tyrosine-protein kinase SYK	Homo sapiens	Kd	=	545.0	nM	PMID[530750]
NPT3431	Individual Protein	Serine/threonine-protein kinase TAO1	Homo sapiens	Kd	=	18757.0	nM	PMID[530750]
NPT3426	Individual Protein	Serine/threonine-protein kinase TAO2	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT3427	Individual Protein	Serine/threonine-protein kinase TAO3	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT3417	Individual Protein	Serine/threonine-protein kinase TBK1	Homo sapiens	Kd	=	1157.0	nM	PMID[530750]
NPT3351	Individual Protein	Tyrosine-protein kinase TEC	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT3352	Individual Protein	Dual specificity testis-specific protein kinase 1	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT3353	Individual Protein	TGF-beta receptor type I	Homo sapiens	Kd	=	2179.0	nM	PMID[530750]
NPT3355	Individual Protein	TGF-beta receptor type II	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT1712	Individual Protein	TRAF2- and NCK-interacting kinase	Homo sapiens	Kd	=	10.0	nM	PMID[530750]
NPT3297	Individual Protein	Non-receptor tyrosine-protein kinase TNK1	Homo sapiens	Kd	=	287.0	nM	PMID[530750]
NPT3245	Individual Protein	Tyrosine kinase non-receptor protein 2	Homo sapiens	Kd	=	1717.0	nM	PMID[530750]
NPT1044	Individual Protein	DNA topoisomerase II alpha	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT322	Individual Protein	DNA topoisomerase II beta	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT3238	Individual Protein	Dual specificity protein kinase TTK	Homo sapiens	Kd	=	30.0	nM	PMID[530750]
NPT3276	Individual Protein	Tyrosine-protein kinase TYK2	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT3398	Individual Protein	Serine/threonine-protein kinase ULK1	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT3382	Individual Protein	Serine/threonine-protein kinase ULK3	Homo sapiens	Kd	=	107.0	nM	PMID[530750]
NPT3256	Individual Protein	Serine/threonine-protein kinase WEE1	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT5472	Individual Protein	Tyrosyl-tRNA synthetase	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT1663	Individual Protein	Tyrosine-protein kinase YES	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT3258	Individual Protein	Mixed lineage kinase 7	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT1284	Protein Family	Protein kinase C (PKC)	Rattus norvegicus	IC50	=	250.0	nM	PMID[530737]
NPT316	Protein Family	Protein kinase C (PKC)	Homo sapiens	IC50	=	60.0	nM	PMID[530738]
NPT316	Protein Family	Protein kinase C (PKC)	Homo sapiens	IC50	=	250.0	nM	PMID[530739]
NPT316	Protein Family	Protein kinase C (PKC)	Homo sapiens	IC50	=	25.0	nM	PMID[530740]
NPT1284	Protein Family	Protein kinase C (PKC)	Rattus norvegicus	IC50	=	0.028	nM	PMID[530741]
NPT1284	Protein Family	Protein kinase C (PKC)	Rattus norvegicus	IC50	=	60.0	nM	PMID[530742]
NPT1284	Protein Family	Protein kinase C (PKC)	Rattus norvegicus	IC50	=	60.0	nM	PMID[530743]
NPT316	Protein Family	Protein kinase C (PKC)	Homo sapiens	IC50	=	33.0	nM	PMID[530744]
NPT2	Others	Unspecified		IC50	=	270.0	nM	PMID[530745]
NPT4086	Protein Complex	Phosphorylase kinase	Homo sapiens	IC50	=	1.7	nM	PMID[530745]
NPT2	Others	Unspecified		IC50	=	250.0	nM	PMID[530746]
NPT2	Others	Unspecified		Ratio	=	19.0	n.a.	PMID[530746]
NPT3814	Protein Complex	Cyclin-dependent kinase 2/cyclin A	Homo sapiens	Residual Activity	=	0.0	%	PMID[530748]
NPT982	Individual Protein	Inhibitor of nuclear factor kappa B kinase alpha subunit	Homo sapiens	Residual Activity	=	3.0	%	PMID[530748]
NPT2544	Protein Complex	Cyclin-dependent kinase 2/cyclin E	Homo sapiens	Residual Activity	=	6.0	%	PMID[530748]
NPT2544	Protein Complex	Cyclin-dependent kinase 2/cyclin E	Homo sapiens	Residual Activity	=	0.0	%	PMID[530748]
NPT981	Individual Protein	Inhibitor of nuclear factor kappa B kinase beta subunit	Homo sapiens	Residual Activity	=	17.0	%	PMID[530748]
NPT4087	Protein Complex	CDK3/cyclin E	Homo sapiens	Residual Activity	=	27.0	%	PMID[530748]
NPT1609	Protein Complex	Casein kinase II	Homo sapiens	Residual Activity	=	93.0	%	PMID[530748]
NPT1609	Protein Complex	Casein kinase II	Homo sapiens	Residual Activity	=	82.0	%	PMID[530748]
NPT981	Individual Protein	Inhibitor of nuclear factor kappa B kinase beta subunit	Homo sapiens	Residual Activity	=	3.0	%	PMID[530748]
NPT4087	Protein Complex	CDK3/cyclin E	Homo sapiens	Residual Activity	=	2.0	%	PMID[530748]
NPT1509	Protein Complex	Cyclin-dependent kinase 5/CDK5 activator 1	Homo sapiens	Residual Activity	=	4.0	%	PMID[530748]
NPT1509	Protein Complex	Cyclin-dependent kinase 5/CDK5 activator 1	Homo sapiens	Residual Activity	=	1.0	%	PMID[530748]
NPT1509	Protein Complex	Cyclin-dependent kinase 5/CDK5 activator 1	Homo sapiens	Residual Activity	=	3.0	%	PMID[530748]
NPT4089	Protein Complex	CDK6/cyclin D3	Homo sapiens	Residual Activity	=	15.0	%	PMID[530748]
NPT676	Individual Protein	Glycogen synthase kinase-3 alpha	Homo sapiens	Residual Activity	=	14.0	%	PMID[530748]
NPT833	Individual Protein	Tyrosine-protein kinase BTK	Homo sapiens	Residual Activity	=	-1.0	%	PMID[530748]
NPT4089	Protein Complex	CDK6/cyclin D3	Homo sapiens	Residual Activity	=	4.0	%	PMID[530748]
NPT4090	Protein Complex	Cyclin-dependent kinase 7/ cyclin H	Homo sapiens	Residual Activity	=	55.0	%	PMID[530748]
NPT676	Individual Protein	Glycogen synthase kinase-3 alpha	Homo sapiens	Residual Activity	=	3.0	%	PMID[530748]
NPT4090	Protein Complex	Cyclin-dependent kinase 7/ cyclin H	Homo sapiens	Residual Activity	=	16.0	%	PMID[530748]
NPT4091	Protein Complex	AMP-activated protein kinase (AMPK) alpha-1/beta-1/gamma-1	Homo sapiens	Residual Activity	=	-1.0	%	PMID[530748]
NPT4091	Protein Complex	AMP-activated protein kinase (AMPK) alpha-1/beta-1/gamma-1	Homo sapiens	Residual Activity	=	0.0	%	PMID[530748]
NPT4092	Protein Complex	CDK9/cyclin T1	Homo sapiens	Residual Activity	=	10.0	%	PMID[530748]
NPT4092	Protein Complex	CDK9/cyclin T1	Homo sapiens	Residual Activity	=	2.0	%	PMID[530748]
NPT1767	Protein Complex	AMP-activated protein kinase, AMPK	Homo sapiens	Residual Activity	=	-5.0	%	PMID[530748]
NPT1767	Protein Complex	AMP-activated protein kinase, AMPK	Homo sapiens	Residual Activity	=	1.0	%	PMID[530748]
NPT1561	Protein Complex	Cyclin-dependent kinase 1/cyclin B1	Homo sapiens	Residual Activity	=	5.0	%	PMID[530748]
NPT1561	Protein Complex	Cyclin-dependent kinase 1/cyclin B1	Homo sapiens	Residual Activity	=	-1.0	%	PMID[530748]
NPT3814	Protein Complex	Cyclin-dependent kinase 2/cyclin A	Homo sapiens	Residual Activity	=	1.0	%	PMID[530748]
NPT982	Individual Protein	Inhibitor of nuclear factor kappa B kinase alpha subunit	Homo sapiens	Residual Activity	=	2.0	%	PMID[530748]
NPT887	Individual Protein	Protein kinase C theta	Homo sapiens	Residual Activity	=	10.0	%	PMID[530748]
NPT887	Individual Protein	Protein kinase C theta	Homo sapiens	Residual Activity	=	5.0	%	PMID[530748]
NPT728	Individual Protein	Serine/threonine-protein kinase AKT	Homo sapiens	Residual Activity	=	101.0	%	PMID[530748]
NPT728	Individual Protein	Serine/threonine-protein kinase AKT	Homo sapiens	Residual Activity	=	37.0	%	PMID[530748]
NPT831	Individual Protein	Serine/threonine-protein kinase PLK1	Homo sapiens	Residual Activity	=	50.0	%	PMID[530748]
NPT831	Individual Protein	Serine/threonine-protein kinase PLK1	Homo sapiens	Residual Activity	=	17.0	%	PMID[530748]
NPT760	Individual Protein	Protein kinase C beta	Homo sapiens	Residual Activity	=	53.0	%	PMID[530748]
NPT760	Individual Protein	Protein kinase C beta	Homo sapiens	Residual Activity	=	13.0	%	PMID[530748]
NPT760	Individual Protein	Protein kinase C beta	Homo sapiens	Residual Activity	=	67.0	%	PMID[530748]
NPT760	Individual Protein	Protein kinase C beta	Homo sapiens	Residual Activity	=	18.0	%	PMID[530748]
NPT880	Individual Protein	Protein kinase C gamma	Homo sapiens	Residual Activity	=	19.0	%	PMID[530748]
NPT880	Individual Protein	Protein kinase C gamma	Homo sapiens	Residual Activity	=	2.0	%	PMID[530748]
NPT881	Individual Protein	Protein kinase C delta	Homo sapiens	Residual Activity	=	18.0	%	PMID[530748]
NPT940	Individual Protein	Serine/threonine-protein kinase mTOR	Homo sapiens	Residual Activity	=	90.0	%	PMID[530748]
NPT940	Individual Protein	Serine/threonine-protein kinase mTOR	Homo sapiens	Residual Activity	=	70.0	%	PMID[530748]
NPT881	Individual Protein	Protein kinase C delta	Homo sapiens	Residual Activity	=	3.0	%	PMID[530748]
NPT761	Individual Protein	Protein kinase C epsilon	Homo sapiens	Residual Activity	=	51.0	%	PMID[530748]
NPT940	Individual Protein	Serine/threonine-protein kinase mTOR	Homo sapiens	Residual Activity	=	89.0	%	PMID[530748]
NPT761	Individual Protein	Protein kinase C epsilon	Homo sapiens	Residual Activity	=	10.0	%	PMID[530748]
NPT940	Individual Protein	Serine/threonine-protein kinase mTOR	Homo sapiens	Residual Activity	=	79.0	%	PMID[530748]
NPT24251	SINGLE PROTEIN	Acyl-CoA dehydrogenase family member 10	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT24252	SINGLE PROTEIN	Acyl-CoA dehydrogenase family member 11	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT24253	SINGLE PROTEIN	Very long-chain specific acyl-CoA dehydrogenase, mitochondrial	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT24254	SINGLE PROTEIN	Peroxisomal acyl-coenzyme A oxidase 1	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT24255	SINGLE PROTEIN	Peroxisomal acyl-coenzyme A oxidase 3	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT24256	SINGLE PROTEIN	Long-chain-fatty-acid--CoA ligase 5	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT24257	SINGLE PROTEIN	Actin-related protein 3	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT24258	SINGLE PROTEIN	Uncharacterized aarF domain-containing protein kinase 1	Homo sapiens	Kd	=	6090.0	nM	PMID[530750]
NPT25893	SINGLE PROTEIN	Uncharacterized aarF domain-containing protein kinase 5	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT24261	SINGLE PROTEIN	Adenylate kinase 2	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT728	Individual Protein	Serine/threonine-protein kinase AKT	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT24263	SINGLE PROTEIN	Serine/threonine-protein kinase A-Raf	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT24264	SINGLE PROTEIN	Breakpoint cluster region protein	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT833	Individual Protein	Tyrosine-protein kinase BTK	Homo sapiens	Kd	=	1567.0	nM	PMID[530750]
NPT24266	SINGLE PROTEIN	Mitotic checkpoint serine/threonine-protein kinase BUB1	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT24268	SINGLE PROTEIN	Cyclin-dependent kinase 10	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT24269	SINGLE PROTEIN	Cyclin-dependent kinase 12	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT24271	SINGLE PROTEIN	Chromodomain-helicase-DNA-binding protein 4	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT2	Others	Unspecified		Kd	>	30000.0	nM	PMID[530750]
NPT24273	SINGLE PROTEIN	Cytochrome c1, heme protein, mitochondrial	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT24276	SINGLE PROTEIN	ATP-dependent RNA helicase DDX1	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT24277	SINGLE PROTEIN	ATP-dependent RNA helicase DDX3X	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT24278	SINGLE PROTEIN	ATP-dependent RNA helicase DDX42	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT24279	SINGLE PROTEIN	Probable ATP-dependent RNA helicase DDX6	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT24280	SINGLE PROTEIN	Delta(24)-sterol reductase	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT25846	SINGLE PROTEIN	ATP-dependent RNA helicase DHX30	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT24281	SINGLE PROTEIN	DnaJ homolog subfamily A member 1	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT25847	SINGLE PROTEIN	Eukaryotic translation initiation factor 5B	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT24284	SINGLE PROTEIN	General transcription and DNA repair factor IIH helicase subunit XPD	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT24285	SINGLE PROTEIN	Serine/threonine-protein kinase/endoribonuclease IRE2	Homo sapiens	Kd	=	908.0	nM	PMID[530750]
NPT24286	SINGLE PROTEIN	Electron transfer flavoprotein subunit beta	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT24287	SINGLE PROTEIN	Phenylalanine--tRNA ligase beta subunit	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT22192	SINGLE PROTEIN	Ferrochelatase, mitochondrial	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT24288	SINGLE PROTEIN	Glycine--tRNA ligase	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT676	Individual Protein	Glycogen synthase kinase-3 alpha	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT24289	SINGLE PROTEIN	Nucleolar GTP-binding protein 1	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT24290	SINGLE PROTEIN	Heme oxygenase 2	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT24291	SINGLE PROTEIN	Putative heat shock protein HSP 90-beta 2	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT24294	SINGLE PROTEIN	Serine/threonine-protein kinase ILK-1	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT24299	SINGLE PROTEIN	S-adenosylmethionine synthase isoform type-2	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT24300	SINGLE PROTEIN	DNA replication licensing factor MCM4	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT24301	SINGLE PROTEIN	Midasin	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT24303	SINGLE PROTEIN	Myosin-14	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT24305	SINGLE PROTEIN	RNA cytidine acetyltransferase	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT24306	SINGLE PROTEIN	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT24308	SINGLE PROTEIN	Dynamin-like 120 kDa protein, mitochondrial	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT24309	SINGLE PROTEIN	Multifunctional protein ADE2	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT2	Others	Unspecified		Kd	=	38.0	nM	PMID[530750]
NPT24311	SINGLE PROTEIN	Pyridoxal kinase	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT24313	SINGLE PROTEIN	Phosphofructokinase platelet type	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT25961	SINGLE PROTEIN	Membrane-associated progesterone receptor component 1	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT24314	SINGLE PROTEIN	Phosphatidylinositol-5-phosphate 4-kinase type-2 alpha	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT24315	SINGLE PROTEIN	Serine/threonine-protein kinase N3	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT24316	SINGLE PROTEIN	cAMP-dependent protein kinase, gamma catalytic subunit	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT24317	SINGLE PROTEIN	AMP-activated protein kinase, gamma-1 subunit	Homo sapiens	Kd	=	352.0	nM	PMID[530750]
NPT24318	SINGLE PROTEIN	AMP-activated protein kinase, gamma-2 subunit	Homo sapiens	Kd	=	868.0	nM	PMID[530750]
NPT24319	SINGLE PROTEIN	cAMP-dependent protein kinase type II-alpha regulatory subunit	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT760	Individual Protein	Protein kinase C beta	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT881	Individual Protein	Protein kinase C delta	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT887	Individual Protein	Protein kinase C theta	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT2	Others	Unspecified		Kd	=	2436.0	nM	PMID[530750]
NPT24320	SINGLE PROTEIN	26S protease regulatory subunit 6B	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT24322	SINGLE PROTEIN	Uncharacterized protein FLJ45252	Homo sapiens	Kd	=	21.0	nM	PMID[530750]
NPT24323	SINGLE PROTEIN	Ras-related protein Rab-10	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT24324	SINGLE PROTEIN	Ras-related protein Rab-27A	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT25850	SINGLE PROTEIN	Ras-related protein Rab-6A	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT24325	SINGLE PROTEIN	Rab-like protein 3	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT24326	SINGLE PROTEIN	GTP-binding nuclear protein Ran	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT24327	SINGLE PROTEIN	Receptor-interacting serine/threonine-protein kinase 3	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT24328	SINGLE PROTEIN	Septin-9	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT24330	SINGLE PROTEIN	Exosome RNA helicase MTR4	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT24331	SINGLE PROTEIN	ADP/ATP translocase 2	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT24332	SINGLE PROTEIN	ADP/ATP translocase 3	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT24333	SINGLE PROTEIN	Structural maintenance of chromosomes protein 1A	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT24334	SINGLE PROTEIN	Structural maintenance of chromosomes protein 2	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT24335	SINGLE PROTEIN	U5 small nuclear ribonucleoprotein 200 kDa helicase	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT24337	SINGLE PROTEIN	STE20-related kinase adapter protein alpha	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT25895	SINGLE PROTEIN	Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT24338	SINGLE PROTEIN	Dual specificity testis-specific protein kinase 2	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT24339	SINGLE PROTEIN	Thyroid hormone receptor-associated protein 3	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT24340	SINGLE PROTEIN	TP53-regulating kinase	Homo sapiens	Kd	=	3840.0	nM	PMID[530750]
NPT24341	SINGLE PROTEIN	Elongation factor Tu, mitochondrial	Homo sapiens	Kd	>	30000.0	nM	PMID[530750]
NPT2	Others	Unspecified		IC50	=	1.8	nM	PMID[530751]
NPT4086	Protein Complex	Phosphorylase kinase	Homo sapiens	IC50	=	1.7	nM	PMID[530751]
NPT25684	SINGLE PROTEIN	Serine/threonine-protein kinase LMTK3	Homo sapiens	IC50	=	79.43	nM	PMID[530752]
NPT25684	SINGLE PROTEIN	Serine/threonine-protein kinase LMTK3	Homo sapiens	Inhibition	=	98.91	%	PMID[530752]
NPT887	Individual Protein	Protein kinase C theta	Homo sapiens	Inhibition	>	50.0	%	PMID[530753]
NPT887	Individual Protein	Protein kinase C theta	Homo sapiens	IC50	=	530.0	nM	PMID[530753]

☑ Note for Activity Records:
☉ The quantitative biological activities were primarily integrated from ChEMBL (Version-30) database and were also directly collected from PubMed literature. PubMed PMID was provided as the reference link for each activity record.

Chemically structural similarity: I. Similar Active Natural Products in NPASS

Top-200 similar NPs were calculated against the active-NP-set (includes 4,3285 NPs with experimentally-derived bioactivity available in NPASS)

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules. Tc lies between [0, 1] where '1' indicates the highest similarity. What is Tanimoto coefficient

● The left chart: Distribution of similarity level between NPC94428 and all remaining natural products in the NPASS database.
● The right table: Most similar natural products (Tc>=0.56 or Top200).

range	Tanimoto Coefficient
0-0.1	374
0.1-0.2	1917
0.2-0.3	10479
0.3-0.4	19046
0.4-0.5	6498
0.5-0.6	3006
0.6-0.7	1331
0.7-0.8	36
0.8-0.85	7
0.85-0.9	1
0.9-0.95	0
0.95-1	2

Similarity Score	Similarity Level	Natural Product ID
1.0	High Similarity	NPC263937
0.8539	High Similarity	NPC313884
0.8539	High Similarity	NPC98371
0.8276	Intermediate Similarity	NPC107836
0.7724	Intermediate Similarity	NPC1203
0.771	Intermediate Similarity	NPC195314
0.7708	Intermediate Similarity	NPC279589
0.7677	Intermediate Similarity	NPC45048
0.7637	Intermediate Similarity	NPC472207
0.7522	Intermediate Similarity	NPC31700
0.7521	Intermediate Similarity	NPC473565
0.7433	Intermediate Similarity	NPC472842
0.7401	Intermediate Similarity	NPC294620
0.7339	Intermediate Similarity	NPC41318
0.7339	Intermediate Similarity	NPC469312
0.7325	Intermediate Similarity	NPC475778
0.7288	Intermediate Similarity	NPC183426
0.7244	Intermediate Similarity	NPC314648
0.7238	Intermediate Similarity	NPC132329
0.7229	Intermediate Similarity	NPC473441
0.7229	Intermediate Similarity	NPC131273
0.7222	Intermediate Similarity	NPC472846
0.7211	Intermediate Similarity	NPC472843
0.7207	Intermediate Similarity	NPC102008
0.7162	Intermediate Similarity	NPC234999
0.7131	Intermediate Similarity	NPC471583
0.7131	Intermediate Similarity	NPC471782
0.7118	Intermediate Similarity	NPC469743
0.7105	Intermediate Similarity	NPC315545
0.7105	Intermediate Similarity	NPC314297
0.7104	Intermediate Similarity	NPC473178
0.709	Intermediate Similarity	NPC278540
0.7087	Intermediate Similarity	NPC314834
0.7085	Intermediate Similarity	NPC160898
0.7085	Intermediate Similarity	NPC311451
0.7083	Intermediate Similarity	NPC472844
0.7061	Intermediate Similarity	NPC315638
0.7061	Intermediate Similarity	NPC313796
0.7061	Intermediate Similarity	NPC313345
0.7061	Intermediate Similarity	NPC314855
0.7059	Intermediate Similarity	NPC476818
0.7022	Intermediate Similarity	NPC32200
0.7018	Intermediate Similarity	NPC62510
0.7004	Intermediate Similarity	NPC193761
0.6978	Remote Similarity	NPC149708
0.6972	Remote Similarity	NPC472119
0.6971	Remote Similarity	NPC33949
0.6942	Remote Similarity	NPC473806
0.6942	Remote Similarity	NPC471634
0.6937	Remote Similarity	NPC129909
0.6933	Remote Similarity	NPC471506
0.693	Remote Similarity	NPC56618
0.693	Remote Similarity	NPC162730
0.6923	Remote Similarity	NPC61435
0.6923	Remote Similarity	NPC74562
0.6923	Remote Similarity	NPC316181
0.6923	Remote Similarity	NPC151781
0.6913	Remote Similarity	NPC277350
0.6911	Remote Similarity	NPC285343
0.6895	Remote Similarity	NPC470003
0.6888	Remote Similarity	NPC79107
0.6888	Remote Similarity	NPC227908
0.6888	Remote Similarity	NPC475424
0.6878	Remote Similarity	NPC473177
0.6867	Remote Similarity	NPC94541
0.6867	Remote Similarity	NPC470843
0.6863	Remote Similarity	NPC478080
0.6856	Remote Similarity	NPC474116
0.6844	Remote Similarity	NPC289299
0.6844	Remote Similarity	NPC57994
0.6842	Remote Similarity	NPC472845
0.6842	Remote Similarity	NPC214428
0.6842	Remote Similarity	NPC28945
0.6835	Remote Similarity	NPC312645
0.6833	Remote Similarity	NPC90415
0.6828	Remote Similarity	NPC212213
0.6828	Remote Similarity	NPC474916
0.6822	Remote Similarity	NPC478157
0.682	Remote Similarity	NPC132642
0.682	Remote Similarity	NPC128115
0.6818	Remote Similarity	NPC203635
0.6811	Remote Similarity	NPC14812
0.681	Remote Similarity	NPC477065
0.6805	Remote Similarity	NPC237901
0.6805	Remote Similarity	NPC195788
0.6804	Remote Similarity	NPC314394
0.6802	Remote Similarity	NPC472323
0.68	Remote Similarity	NPC192306
0.679	Remote Similarity	NPC476492
0.6789	Remote Similarity	NPC220852
0.6786	Remote Similarity	NPC472097
0.6783	Remote Similarity	NPC57398
0.6777	Remote Similarity	NPC245756
0.6777	Remote Similarity	NPC235885
0.6773	Remote Similarity	NPC243058
0.676	Remote Similarity	NPC81175
0.6753	Remote Similarity	NPC477135
0.6752	Remote Similarity	NPC469589
0.675	Remote Similarity	NPC61813
0.6747	Remote Similarity	NPC474183
0.6738	Remote Similarity	NPC244741
0.6737	Remote Similarity	NPC244856
0.6737	Remote Similarity	NPC472098
0.6736	Remote Similarity	NPC229893
0.6725	Remote Similarity	NPC192674
0.6723	Remote Similarity	NPC469928
0.6722	Remote Similarity	NPC2395
0.6721	Remote Similarity	NPC323752
0.6713	Remote Similarity	NPC158129
0.6713	Remote Similarity	NPC126492
0.6712	Remote Similarity	NPC133261
0.6712	Remote Similarity	NPC473189
0.671	Remote Similarity	NPC476073
0.6709	Remote Similarity	NPC89508
0.6708	Remote Similarity	NPC475476
0.6708	Remote Similarity	NPC242446
0.6707	Remote Similarity	NPC282033
0.6704	Remote Similarity	NPC260909
0.6697	Remote Similarity	NPC472104
0.6697	Remote Similarity	NPC472444
0.6696	Remote Similarity	NPC181502
0.6696	Remote Similarity	NPC85066
0.6696	Remote Similarity	NPC46413
0.6695	Remote Similarity	NPC475841
0.6695	Remote Similarity	NPC474145
0.6682	Remote Similarity	NPC311858
0.6681	Remote Similarity	NPC239954
0.6681	Remote Similarity	NPC97388
0.6681	Remote Similarity	NPC473650
0.6681	Remote Similarity	NPC474412
0.6681	Remote Similarity	NPC160527
0.668	Remote Similarity	NPC86078
0.6667	Remote Similarity	NPC471564
0.6667	Remote Similarity	NPC75634
0.6667	Remote Similarity	NPC471303
0.6667	Remote Similarity	NPC53344
0.6667	Remote Similarity	NPC211997
0.6654	Remote Similarity	NPC476493
0.6653	Remote Similarity	NPC323198
0.6653	Remote Similarity	NPC330009
0.6653	Remote Similarity	NPC203614
0.6653	Remote Similarity	NPC204491
0.6653	Remote Similarity	NPC475258
0.6639	Remote Similarity	NPC306644
0.6639	Remote Similarity	NPC141428
0.6639	Remote Similarity	NPC229348
0.6639	Remote Similarity	NPC236424
0.6639	Remote Similarity	NPC473547
0.6638	Remote Similarity	NPC314957
0.6636	Remote Similarity	NPC256268
0.6636	Remote Similarity	NPC472443
0.6629	Remote Similarity	NPC227824
0.6627	Remote Similarity	NPC477066
0.6626	Remote Similarity	NPC191382
0.6626	Remote Similarity	NPC56109
0.6626	Remote Similarity	NPC155444
0.6625	Remote Similarity	NPC96131
0.6625	Remote Similarity	NPC472285
0.6624	Remote Similarity	NPC82370
0.6624	Remote Similarity	NPC250129
0.6623	Remote Similarity	NPC79129
0.6623	Remote Similarity	NPC249150
0.6623	Remote Similarity	NPC49196
0.6623	Remote Similarity	NPC81654
0.6623	Remote Similarity	NPC195461
0.6623	Remote Similarity	NPC313985
0.6622	Remote Similarity	NPC19679
0.6621	Remote Similarity	NPC472122
0.6621	Remote Similarity	NPC24594
0.6621	Remote Similarity	NPC134586
0.6614	Remote Similarity	NPC478029
0.6614	Remote Similarity	NPC470784
0.6614	Remote Similarity	NPC470785
0.6612	Remote Similarity	NPC909
0.6612	Remote Similarity	NPC112547
0.6612	Remote Similarity	NPC475338
0.6612	Remote Similarity	NPC24370
0.6612	Remote Similarity	NPC319232
0.6611	Remote Similarity	NPC274842
0.661	Remote Similarity	NPC284102
0.661	Remote Similarity	NPC478158
0.6609	Remote Similarity	NPC168911
0.6609	Remote Similarity	NPC165599
0.6608	Remote Similarity	NPC55493
0.6606	Remote Similarity	NPC15840
0.6601	Remote Similarity	NPC478081
0.66	Remote Similarity	NPC478028
0.6598	Remote Similarity	NPC473310
0.6597	Remote Similarity	NPC151976
0.6597	Remote Similarity	NPC94157
0.6597	Remote Similarity	NPC87856
0.6594	Remote Similarity	NPC205403
0.6593	Remote Similarity	NPC329858
0.6591	Remote Similarity	NPC219848
0.659	Remote Similarity	NPC472436
0.659	Remote Similarity	NPC478006
0.6589	Remote Similarity	NPC153400
0.6585	Remote Similarity	NPC476491
0.6585	Remote Similarity	NPC473185
0.6585	Remote Similarity	NPC57690

Chemically structural similarity: II. Similar Clinical/Approved Drugs

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules.

● The left chart: Distribution of similarity level between NPC94428 and all drugs/candidates.
● The right table: Most similar clinical/approved drugs (Tc>=0.56 or Top200).

range	Tanimoto Coefficient
0-0.1	205
0.1-0.2	587
0.2-0.3	860
0.3-0.4	1951
0.4-0.5	3146
0.5-0.6	1926
0.6-0.7	447
0.7-0.8	20
0.8-0.85	4
0.85-0.9	0
0.9-0.95	3
0.95-1	1

Similarity Score	Similarity Level	Drug ID	Developmental Stage
0.9452	High Similarity	NPD7769	Phase 3
0.9279	High Similarity	NPD6455	Phase 3
0.9234	High Similarity	NPD6717	Clinical (unspecified phase)
0.9005	High Similarity	NPD7770	Phase 3
0.8545	High Similarity	NPD6978	Phase 2
0.8545	High Similarity	NPD6977	Clinical (unspecified phase)
0.8539	High Similarity	NPD6976	Clinical (unspecified phase)
0.8348	Intermediate Similarity	NPD7921	Approved
0.8045	Intermediate Similarity	NPD7073	Clinical (unspecified phase)
0.7621	Intermediate Similarity	NPD6456	Discontinued
0.7366	Intermediate Similarity	NPD4901	Clinical (unspecified phase)
0.7342	Intermediate Similarity	NPD7688	Phase 1
0.7339	Intermediate Similarity	NPD6995	Phase 1
0.7336	Intermediate Similarity	NPD7181	Phase 3
0.7289	Intermediate Similarity	NPD6732	Clinical (unspecified phase)
0.725	Intermediate Similarity	NPD6142	Phase 3
0.7212	Intermediate Similarity	NPD7001	Phase 3
0.7207	Intermediate Similarity	NPD7778	Approved
0.7207	Intermediate Similarity	NPD53	Approved
0.7207	Intermediate Similarity	NPD7777	Approved
0.7185	Intermediate Similarity	NPD7767	Approved
0.7162	Intermediate Similarity	NPD4900	Clinical (unspecified phase)
0.7156	Intermediate Similarity	NPD5721	Clinical (unspecified phase)
0.715	Intermediate Similarity	NPD6452	Discontinued
0.7126	Intermediate Similarity	NPD5488	Discontinued
0.7095	Intermediate Similarity	NPD3746	Discontinued
0.7076	Intermediate Similarity	NPD5507	Approved
0.7076	Intermediate Similarity	NPD5506	Approved
0.7073	Intermediate Similarity	NPD5821	Approved
0.7048	Intermediate Similarity	NPD2920	Discontinued
0.7009	Intermediate Similarity	NPD5003	Discontinued
0.7008	Intermediate Similarity	NPD7772	Phase 3
0.7	Intermediate Similarity	NPD7397	Approved
0.7	Intermediate Similarity	NPD7398	Approved
0.7	Intermediate Similarity	NPD6965	Clinical (unspecified phase)
0.6978	Remote Similarity	NPD4987	Clinical (unspecified phase)
0.697	Remote Similarity	NPD5834	Phase 3
0.697	Remote Similarity	NPD5835	Phase 3
0.6966	Remote Similarity	NPD4897	Phase 2
0.6947	Remote Similarity	NPD6661	Clinical (unspecified phase)
0.6943	Remote Similarity	NPD6987	Phase 1
0.6937	Remote Similarity	NPD3785	Clinical (unspecified phase)
0.6936	Remote Similarity	NPD6733	Discontinued
0.6913	Remote Similarity	NPD5530	Phase 1
0.6895	Remote Similarity	NPD7417	Discontinued
0.6892	Remote Similarity	NPD2564	Approved
0.6892	Remote Similarity	NPD2565	Phase 2
0.6878	Remote Similarity	NPD4948	Discontinued
0.6878	Remote Similarity	NPD7878	Phase 2
0.6872	Remote Similarity	NPD7000	Clinical (unspecified phase)
0.6872	Remote Similarity	NPD6999	Discontinued
0.687	Remote Similarity	NPD5425	Phase 1
0.686	Remote Similarity	NPD7268	Clinical (unspecified phase)
0.6858	Remote Similarity	NPD6206	Phase 1
0.6855	Remote Similarity	NPD8017	Clinical (unspecified phase)
0.6855	Remote Similarity	NPD8016	Phase 3
0.6847	Remote Similarity	NPD4334	Discontinued
0.6846	Remote Similarity	NPD7271	Approved
0.6844	Remote Similarity	NPD4602	Approved
0.6831	Remote Similarity	NPD7710	Clinical (unspecified phase)
0.6828	Remote Similarity	NPD7889	Clinical (unspecified phase)
0.6828	Remote Similarity	NPD6261	Phase 3
0.6815	Remote Similarity	NPD4938	Phase 2
0.681	Remote Similarity	NPD7453	Approved
0.681	Remote Similarity	NPD7452	Approved
0.6805	Remote Similarity	NPD8465	Approved
0.6805	Remote Similarity	NPD8429	Approved
0.6805	Remote Similarity	NPD8466	Approved
0.6805	Remote Similarity	NPD8428	Approved
0.6805	Remote Similarity	NPD8427	Approved
0.6805	Remote Similarity	NPD8467	Approved
0.6802	Remote Similarity	NPD5891	Approved
0.6798	Remote Similarity	NPD6249	Phase 2
0.6798	Remote Similarity	NPD6248	Phase 2
0.679	Remote Similarity	NPD7730	Approved
0.679	Remote Similarity	NPD7731	Approved
0.6789	Remote Similarity	NPD7950	Approved
0.6789	Remote Similarity	NPD7790	Approved
0.6789	Remote Similarity	NPD7953	Approved
0.6789	Remote Similarity	NPD7789	Approved
0.6789	Remote Similarity	NPD7791	Approved
0.6789	Remote Similarity	NPD7952	Approved
0.6789	Remote Similarity	NPD7951	Approved
0.6781	Remote Similarity	NPD7665	Phase 2
0.6781	Remote Similarity	NPD7666	Phase 3
0.6776	Remote Similarity	NPD5021	Discontinued
0.677	Remote Similarity	NPD4427	Phase 2
0.6765	Remote Similarity	NPD8000	Clinical (unspecified phase)
0.6758	Remote Similarity	NPD5899	Approved
0.6758	Remote Similarity	NPD5898	Approved
0.6758	Remote Similarity	NPD5897	Approved
0.6753	Remote Similarity	NPD5487	Phase 1
0.6741	Remote Similarity	NPD6281	Approved
0.674	Remote Similarity	NPD6449	Clinical (unspecified phase)
0.6735	Remote Similarity	NPD7824	Approved
0.6725	Remote Similarity	NPD3800	Clinical (unspecified phase)
0.6724	Remote Similarity	NPD5426	Phase 3
0.6712	Remote Similarity	NPD6344	Clinical (unspecified phase)
0.6712	Remote Similarity	NPD6227	Discontinued
0.6704	Remote Similarity	NPD8426	Approved
0.6704	Remote Similarity	NPD8460	Approved
0.6704	Remote Similarity	NPD8459	Approved
0.6704	Remote Similarity	NPD8425	Approved
0.6695	Remote Similarity	NPD7470	Discontinued
0.6682	Remote Similarity	NPD5444	Phase 1
0.6681	Remote Similarity	NPD4886	Phase 2
0.6681	Remote Similarity	NPD4315	Phase 2
0.668	Remote Similarity	NPD7776	Approved
0.6667	Remote Similarity	NPD4852	Phase 2
0.6667	Remote Similarity	NPD7589	Clinical (unspecified phase)
0.6667	Remote Similarity	NPD6716	Phase 1
0.6667	Remote Similarity	NPD8093	Discontinued
0.6667	Remote Similarity	NPD8322	Phase 2
0.6653	Remote Similarity	NPD4414	Discontinued
0.6653	Remote Similarity	NPD5040	Clinical (unspecified phase)
0.6652	Remote Similarity	NPD6141	Clinical (unspecified phase)
0.6652	Remote Similarity	NPD7712	Clinical (unspecified phase)
0.6652	Remote Similarity	NPD6138	Clinical (unspecified phase)
0.6652	Remote Similarity	NPD3390	Phase 2
0.6651	Remote Similarity	NPD2882	Phase 1
0.6637	Remote Similarity	NPD7424	Clinical (unspecified phase)
0.6627	Remote Similarity	NPD6970	Phase 2
0.6627	Remote Similarity	NPD7576	Discontinued
0.6626	Remote Similarity	NPD7781	Approved
0.6626	Remote Similarity	NPD7780	Approved
0.6623	Remote Similarity	NPD4600	Approved
0.6623	Remote Similarity	NPD4601	Approved
0.6623	Remote Similarity	NPD7944	Discontinued
0.6621	Remote Similarity	NPD6375	Clinical (unspecified phase)
0.6613	Remote Similarity	NPD7797	Approved
0.6613	Remote Similarity	NPD7796	Approved
0.6601	Remote Similarity	NPD7857	Phase 3
0.6601	Remote Similarity	NPD7856	Phase 2
0.6599	Remote Similarity	NPD5801	Clinical (unspecified phase)
0.6596	Remote Similarity	NPD7222	Phase 2
0.659	Remote Similarity	NPD1325	Approved
0.659	Remote Similarity	NPD1326	Approved
0.6586	Remote Similarity	NPD4373	Phase 2
0.6581	Remote Similarity	NPD5901	Discontinued
0.6581	Remote Similarity	NPD7103	Approved
0.658	Remote Similarity	NPD7621	Clinical (unspecified phase)
0.6579	Remote Similarity	NPD8364	Approved
0.6579	Remote Similarity	NPD3403	Clinical (unspecified phase)
0.6579	Remote Similarity	NPD8363	Approved
0.6574	Remote Similarity	NPD4554	Clinical (unspecified phase)
0.6564	Remote Similarity	NPD5912	Clinical (unspecified phase)
0.6564	Remote Similarity	NPD5913	Phase 3
0.6556	Remote Similarity	NPD8325	Phase 3
0.6556	Remote Similarity	NPD8406	Clinical (unspecified phase)
0.6556	Remote Similarity	NPD8327	Clinical (unspecified phase)
0.6556	Remote Similarity	NPD8326	Phase 3
0.6549	Remote Similarity	NPD7197	Approved
0.6538	Remote Similarity	NPD3777	Phase 3
0.6537	Remote Similarity	NPD4397	Phase 1
0.6535	Remote Similarity	NPD7860	Clinical (unspecified phase)
0.6532	Remote Similarity	NPD8464	Clinical (unspecified phase)
0.6531	Remote Similarity	NPD7716	Approved
0.6531	Remote Similarity	NPD7717	Approved
0.653	Remote Similarity	NPD8365	Clinical (unspecified phase)
0.6527	Remote Similarity	NPD8096	Phase 3
0.6527	Remote Similarity	NPD8097	Phase 3
0.6523	Remote Similarity	NPD5807	Phase 2
0.6522	Remote Similarity	NPD7818	Clinical (unspecified phase)
0.6516	Remote Similarity	NPD7726	Phase 1
0.6511	Remote Similarity	NPD8098	Approved
0.6506	Remote Similarity	NPD6962	Phase 2
0.6502	Remote Similarity	NPD7867	Phase 1
0.65	Remote Similarity	NPD7276	Approved
0.65	Remote Similarity	NPD7277	Approved
0.65	Remote Similarity	NPD6492	Phase 2
0.6498	Remote Similarity	NPD8358	Approved
0.6496	Remote Similarity	NPD6975	Discontinued
0.6493	Remote Similarity	NPD6158	Phase 2
0.6493	Remote Similarity	NPD6476	Clinical (unspecified phase)
0.6491	Remote Similarity	NPD6630	Clinical (unspecified phase)
0.6486	Remote Similarity	NPD5398	Clinical (unspecified phase)
0.6483	Remote Similarity	NPD7958	Clinical (unspecified phase)
0.6483	Remote Similarity	NPD4862	Clinical (unspecified phase)
0.6483	Remote Similarity	NPD7957	Phase 1
0.6478	Remote Similarity	NPD4418	Discontinued
0.6473	Remote Similarity	NPD5596	Phase 2
0.6471	Remote Similarity	NPD4520	Approved
0.6468	Remote Similarity	NPD4638	Approved
0.6468	Remote Similarity	NPD4639	Approved
0.6468	Remote Similarity	NPD4640	Approved
0.6466	Remote Similarity	NPD7946	Pre-registration
0.6466	Remote Similarity	NPD4952	Phase 3
0.6461	Remote Similarity	NPD7395	Discontinued
0.6457	Remote Similarity	NPD4561	Discontinued
0.6457	Remote Similarity	NPD7025	Clinical (unspecified phase)
0.6456	Remote Similarity	NPD5429	Discontinued
0.6452	Remote Similarity	NPD6292	Clinical (unspecified phase)
0.6449	Remote Similarity	NPD4326	Phase 2
0.6447	Remote Similarity	NPD4499	Approved
0.6446	Remote Similarity	NPD7218	Clinical (unspecified phase)
0.6441	Remote Similarity	NPD8489	Phase 1
0.6437	Remote Similarity	NPD3925	Approved
0.6432	Remote Similarity	NPD2383	Phase 1
0.6429	Remote Similarity	NPD8329	Phase 3
0.6429	Remote Similarity	NPD4204	Approved

Bioactivity similarity: Similar Natural Products in NPASS

Bioactivity similarity was calculated based on bioactivity descriptors of compounds. The bioactivity descriptors were calculated by a recently developed AI algorithm Chemical Checker (CC) [Nature Biotechnology, 38:1087–1096, 2020; Nature Communications, 12:3932, 2021], which evaluated bioactivity similarities at five levels:
☉ A: chemistry similarity;
☉ B: biological targets similarity;
☉ C: networks similarity;
☉ D: cell-based bioactivity similarity;
☉ E: similarity based on clinical data.

Those 5 categories of CC bioactivity descriptors were calculated and then subjected to manifold projection using UMAP algorithm, to project all NPs on a 2-Dimensional space. The current NP was highlighted with a small circle in the 2-D map. Below figures: left-to-right, A-to-E.

A: chemistry similarity

B: biological targets similarity

C: networks similarity

D: cell-based bioactivity similarity

E: similarity based on clinical data