NPASS Compound

Natural Product: NPC195788

Natural Product ID	NPC195788
Common Name ? The InCHIKey will be temporarily assigned as the "Common Name" if no IUPAC name or alternative short name is available.	Vinblastine
IUPAC Name	n.a.
Synonyms	Velban; Vinblastine; [3H]-Vinblastine
Synthetic Gene Cluster	n.a.
ChEMBL Identifier	CHEMBL159
PubChem CID	13342
Chemical Classification	CHEMONTID:0000000 [Organic compounds] [CHEMONTID:0000279] Alkaloids and derivatives [CHEMONTID:0002756] Vinca alkaloids

The Chemical Classification was calculated by Classyfire, a software for chemical taxonomy calculation. Reference: DOI:10.1186/s13321-016-0174-y.

Chemical Representations

RDKit 3D 117125 0 0 0 0 0 0 0 0999 V2000 -7.7959 -2.3783 -0.5499 C 0 0 0 0 0 0 0 0 0 0 0 0 -6.2974 -2.5681 -0.5155 C 0 0 0 0 0 0 0 0 0 0 0 0 -5.6417 -2.0368 -1.7797 C 0 0 2 0 0 0 0 0 0 0 0 0 -4.1493 -2.2875 -1.6183 C 0 0 0 0 0 0 0 0 0 0 0 0 -3.5615 -0.8542 -1.6383 C 0 0 1 0 0 0 0 0 0 0 0 0 -2.1699 -0.7924 -1.2330 C 0 0 0 0 0 0 0 0 0 0 0 0 -1.7183 0.4775 -0.4964 C 0 0 2 0 0 0 0 0 0 0 0 0 -0.5382 0.0778 0.3545 C 0 0 0 0 0 0 0 0 0 0 0 0 0.7082 0.6450 0.2412 C 0 0 0 0 0 0 0 0 0 0 0 0 1.7682 0.3030 1.0943 C 0 0 0 0 0 0 0 0 0 0 0 0 1.5720 -0.6304 2.0808 C 0 0 0 0 0 0 0 0 0 0 0 0 0.3210 -1.2112 2.2054 C 0 0 0 0 0 0 0 0 0 0 0 0 -0.7113 -0.8508 1.3428 C 0 0 0 0 0 0 0 0 0 0 0 0 -1.9048 -1.4884 1.5374 O 0 0 0 0 0 0 0 0 0 0 0 0 -2.1201 -2.4521 2.5472 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7932 -0.8476 2.8251 N 0 0 0 0 0 0 0 0 0 0 0 0 2.8470 -1.4710 4.1167 C 0 0 0 0 0 0 0 0 0 0 0 0 3.8401 -0.3081 1.9815 C 0 0 2 0 0 0 0 0 0 0 0 0 3.1720 0.7761 1.1913 C 0 0 2 0 0 0 0 0 0 0 0 0 3.1235 2.0811 1.9751 C 0 0 0 0 0 0 0 0 0 0 0 0 2.9426 3.0844 0.8667 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7907 2.5411 -0.1801 N 0 0 0 0 0 0 0 0 0 0 0 0 4.9969 3.2783 -0.1773 C 0 0 0 0 0 0 0 0 0 0 0 0 6.1994 2.5324 0.2807 C 0 0 0 0 0 0 0 0 0 0 0 0 6.2982 1.2186 0.1974 C 0 0 0 0 0 0 0 0 0 0 0 0 5.1461 0.4796 -0.3823 C 0 0 2 0 0 0 0 0 0 0 0 0 5.2959 0.6856 -1.9009 C 0 0 0 0 0 0 0 0 0 0 0 0 6.5817 0.1880 -2.4495 C 0 0 0 0 0 0 0 0 0 0 0 0 3.8257 1.1363 -0.0711 C 0 0 1 0 0 0 0 0 0 0 0 0 5.2107 -0.9596 -0.0526 C 0 0 2 0 0 0 0 0 0 0 0 0 4.4461 -1.3864 1.1861 C 0 0 2 0 0 0 0 0 0 0 0 0 3.4093 -2.3946 0.8608 C 0 0 0 0 0 0 0 0 0 0 0 0 3.3193 -3.5258 1.3682 O 0 0 0 0 0 0 0 0 0 0 0 0 2.4528 -2.0648 -0.0903 O 0 0 0 0 0 0 0 0 0 0 0 0 1.4273 -2.9703 -0.4662 C 0 0 0 0 0 0 0 0 0 0 0 0 5.3248 -2.0790 2.0728 O 0 0 0 0 0 0 0 0 0 0 0 0 6.5299 -1.4788 -0.0220 O 0 0 0 0 0 0 0 0 0 0 0 0 6.9384 -2.5098 -0.8319 C 0 0 0 0 0 0 0 0 0 0 0 0 6.0931 -2.9825 -1.6039 O 0 0 0 0 0 0 0 0 0 0 0 0 8.3454 -3.0412 -0.7849 C 0 0 0 0 0 0 0 0 0 0 0 0 -2.8028 1.1527 0.2274 C 0 0 0 0 0 0 0 0 0 0 0 0 -3.8511 1.8641 -0.2726 C 0 0 0 0 0 0 0 0 0 0 0 0 -4.1617 2.2227 -1.6788 C 0 0 0 0 0 0 0 0 0 0 0 0 -5.2722 1.5781 -2.3694 C 0 0 0 0 0 0 0 0 0 0 0 0 -5.2627 0.2349 -2.7486 N 0 0 0 0 0 0 0 0 0 0 0 0 -3.9690 -0.3506 -2.9841 C 0 0 0 0 0 0 0 0 0 0 0 0 -6.0239 -0.5997 -1.9058 C 0 0 0 0 0 0 0 0 0 0 0 0 -4.6005 2.2970 0.8570 C 0 0 0 0 0 0 0 0 0 0 0 0 -5.7576 3.0451 0.9609 C 0 0 0 0 0 0 0 0 0 0 0 0 -6.3178 3.3505 2.1979 C 0 0 0 0 0 0 0 0 0 0 0 0 -5.6999 2.8937 3.3385 C 0 0 0 0 0 0 0 0 0 0 0 0 -4.5470 2.1483 3.2354 C 0 0 0 0 0 0 0 0 0 0 0 0 -4.0070 1.8574 1.9713 C 0 0 0 0 0 0 0 0 0 0 0 0 -2.9313 1.1751 1.5929 N 0 0 0 0 0 0 0 0 0 0 0 0 -1.1385 1.4402 -1.4628 C 0 0 0 0 0 0 0 0 0 0 0 0 -0.8969 1.1693 -2.6650 O 0 0 0 0 0 0 0 0 0 0 0 0 -0.8184 2.7556 -1.0679 O 0 0 0 0 0 0 0 0 0 0 0 0 -0.2634 3.6844 -1.9885 C 0 0 0 0 0 0 0 0 0 0 0 0 -6.1723 -2.8190 -2.8287 O 0 0 0 0 0 0 0 0 0 0 0 0 -8.0736 -1.3050 -0.5467 H 0 0 0 0 0 0 0 0 0 0 0 0 -8.1855 -2.8499 -1.4704 H 0 0 0 0 0 0 0 0 0 0 0 0 -8.2159 -2.9324 0.3108 H 0 0 0 0 0 0 0 0 0 0 0 0 -6.1100 -3.6453 -0.3544 H 0 0 0 0 0 0 0 0 0 0 0 0 -5.8812 -2.0343 0.3775 H 0 0 0 0 0 0 0 0 0 0 0 0 -3.7153 -2.8346 -2.4787 H 0 0 0 0 0 0 0 0 0 0 0 0 -3.8906 -2.8124 -0.7026 H 0 0 0 0 0 0 0 0 0 0 0 0 -4.1768 -0.4032 -0.7883 H 0 0 0 0 0 0 0 0 0 0 0 0 -1.5563 -0.8311 -2.2017 H 0 0 0 0 0 0 0 0 0 0 0 0 -1.8095 -1.7199 -0.7232 H 0 0 0 0 0 0 0 0 0 0 0 0 0.8886 1.3549 -0.5234 H 0 0 0 0 0 0 0 0 0 0 0 0 0.1525 -1.9465 2.9776 H 0 0 0 0 0 0 0 0 0 0 0 0 -3.2221 -2.6338 2.6043 H 0 0 0 0 0 0 0 0 0 0 0 0 -1.6127 -3.4127 2.3047 H 0 0 0 0 0 0 0 0 0 0 0 0 -1.8397 -2.0493 3.5408 H 0 0 0 0 0 0 0 0 0 0 0 0 2.0514 -0.9917 4.7588 H 0 0 0 0 0 0 0 0 0 0 0 0 2.5987 -2.5523 4.0989 H 0 0 0 0 0 0 0 0 0 0 0 0 3.8238 -1.3720 4.6110 H 0 0 0 0 0 0 0 0 0 0 0 0 4.5305 0.2059 2.6847 H 0 0 0 0 0 0 0 0 0 0 0 0 4.0875 2.1913 2.5125 H 0 0 0 0 0 0 0 0 0 0 0 0 2.2480 2.0648 2.6687 H 0 0 0 0 0 0 0 0 0 0 0 0 3.3090 4.1007 1.1756 H 0 0 0 0 0 0 0 0 0 0 0 0 1.8831 3.1442 0.5978 H 0 0 0 0 0 0 0 0 0 0 0 0 4.9308 4.1561 0.5453 H 0 0 0 0 0 0 0 0 0 0 0 0 5.1947 3.8184 -1.1554 H 0 0 0 0 0 0 0 0 0 0 0 0 7.0479 3.0634 0.7053 H 0 0 0 0 0 0 0 0 0 0 0 0 7.1491 0.6274 0.5155 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0807 1.7082 -2.2024 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4785 0.0640 -2.3722 H 0 0 0 0 0 0 0 0 0 0 0 0 6.4603 -0.7132 -3.0453 H 0 0 0 0 0 0 0 0 0 0 0 0 6.9318 0.9730 -3.1977 H 0 0 0 0 0 0 0 0 0 0 0 0 7.4119 0.1706 -1.7128 H 0 0 0 0 0 0 0 0 0 0 0 0 3.1283 0.7574 -0.8902 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7188 -1.5209 -0.8759 H 0 0 0 0 0 0 0 0 0 0 0 0 1.1655 -3.6459 0.3651 H 0 0 0 0 0 0 0 0 0 0 0 0 1.8067 -3.5175 -1.3697 H 0 0 0 0 0 0 0 0 0 0 0 0 0.5642 -2.3509 -0.7986 H 0 0 0 0 0 0 0 0 0 0 0 0 5.5568 -2.9665 1.7002 H 0 0 0 0 0 0 0 0 0 0 0 0 8.6596 -3.4144 -1.7685 H 0 0 0 0 0 0 0 0 0 0 0 0 8.3992 -3.8690 -0.0591 H 0 0 0 0 0 0 0 0 0 0 0 0 9.0251 -2.2291 -0.4136 H 0 0 0 0 0 0 0 0 0 0 0 0 -4.4438 3.3455 -1.6314 H 0 0 0 0 0 0 0 0 0 0 0 0 -3.2147 2.2953 -2.2335 H 0 0 0 0 0 0 0 0 0 0 0 0 -6.2001 1.8090 -1.7436 H 0 0 0 0 0 0 0 0 0 0 0 0 -5.5224 2.1618 -3.3154 H 0 0 0 0 0 0 0 0 0 0 0 0 -4.1809 -1.1824 -3.7310 H 0 0 0 0 0 0 0 0 0 0 0 0 -3.2714 0.2742 -3.5220 H 0 0 0 0 0 0 0 0 0 0 0 0 -7.0718 -0.6106 -2.3154 H 0 0 0 0 0 0 0 0 0 0 0 0 -6.1622 -0.1834 -0.8655 H 0 0 0 0 0 0 0 0 0 0 0 0 -6.2469 3.4051 0.0840 H 0 0 0 0 0 0 0 0 0 0 0 0 -7.2224 3.9350 2.2842 H 0 0 0 0 0 0 0 0 0 0 0 0 -6.1585 3.1466 4.2895 H 0 0 0 0 0 0 0 0 0 0 0 0 -4.0715 1.7954 4.1389 H 0 0 0 0 0 0 0 0 0 0 0 0 -2.2947 0.7709 2.3279 H 0 0 0 0 0 0 0 0 0 0 0 0 -0.9129 3.8427 -2.8756 H 0 0 0 0 0 0 0 0 0 0 0 0 -0.1990 4.6528 -1.4457 H 0 0 0 0 0 0 0 0 0 0 0 0 0.7747 3.4029 -2.2645 H 0 0 0 0 0 0 0 0 0 0 0 0 -6.2122 -3.7424 -2.4764 H 0 0 0 0 0 0 0 0 0 0 0 0 1 2 1 0 2 3 1 0 3 4 1 0 4 5 1 0 5 6 1 0 6 7 1 0 7 8 1 0 8 9 2 0 9 10 1 0 10 11 2 0 11 12 1 0 12 13 2 0 13 14 1 0 14 15 1 0 11 16 1 0 16 17 1 0 16 18 1 0 18 19 1 0 19 20 1 1 20 21 1 0 21 22 1 0 22 23 1 0 23 24 1 0 24 25 2 0 25 26 1 0 26 27 1 6 27 28 1 0 26 29 1 0 26 30 1 0 30 31 1 0 31 32 1 0 32 33 2 0 32 34 1 0 34 35 1 0 31 36 1 1 30 37 1 0 37 38 1 0 38 39 2 0 38 40 1 0 7 41 1 0 41 42 2 0 42 43 1 0 43 44 1 0 44 45 1 0 45 46 1 0 45 47 1 0 42 48 1 0 48 49 2 0 49 50 1 0 50 51 2 0 51 52 1 0 52 53 2 0 53 54 1 0 7 55 1 6 55 56 2 0 55 57 1 0 57 58 1 0 3 59 1 6 47 3 1 0 53 48 1 0 46 5 1 0 13 8 1 0 31 18 1 0 54 41 1 0 19 10 1 0 29 22 1 0 29 19 1 0 1 60 1 0 1 61 1 0 1 62 1 0 2 63 1 0 2 64 1 0 4 65 1 0 4 66 1 0 5 67 1 1 6 68 1 0 6 69 1 0 9 70 1 0 12 71 1 0 15 72 1 0 15 73 1 0 15 74 1 0 17 75 1 0 17 76 1 0 17 77 1 0 18 78 1 1 20 79 1 0 20 80 1 0 21 81 1 0 21 82 1 0 23 83 1 0 23 84 1 0 24 85 1 0 25 86 1 0 27 87 1 0 27 88 1 0 28 89 1 0 28 90 1 0 28 91 1 0 29 92 1 6 30 93 1 6 35 94 1 0 35 95 1 0 35 96 1 0 36 97 1 0 40 98 1 0 40 99 1 0 40100 1 0 43101 1 0 43102 1 0 44103 1 0 44104 1 0 46105 1 0 46106 1 0 47107 1 0 47108 1 0 49109 1 0 50110 1 0 51111 1 0 52112 1 0 54113 1 0 58114 1 0 58115 1 0 58116 1 0 59117 1 0 M END

Standard InCHIKey	JXLYSJRDGCGARV-CFWMRBGOSA-N
Standard InCHI	InChI=1S/C46H58N4O9/c1-8-42(54)23-28-24-45(40(52)57-6,36-30(15-19-49(25-28)26-42)29-13-10-11-14-33(29)47-36)32-21-31-34(22-35(32)56-5)48(4)38-44(31)17-20-50-18-12-16-43(9-2,37(44)50)39(59-27(3)51)46(38,55)41(53)58-7/h10-14,16,21-22,28,37-39,47,54-55H,8-9,15,17-20,23-26H2,1-7H3/t28-,37-,38+,39+,42-,43+,44+,45-,46-/m0/s1
SMILES	CC[C@@]1(C[C@H]2C[C@](c3cc4c(cc3OC)N(C)[C@@H]3[C@@]54CCN4CC=C[C@](CC)([C@@H]54)[C@H]([C@@]3(C(=O)OC)O)OC(=O)C)(c3c(CCN(C2)C1)c1ccccc1[nH]3)C(=O)OC)O

Calculated Properties

Physi-Chem Properties

MedChem Properties

ADMET Properties (ADMETlab3.0)

ADMET: Absorption

ADMET: Distribution

ADMET: Metabolism

ADMET: Excretion

ADMET: Toxicity

Species Source

Organism ID	Organism Name	Taxonomy Level	Family	SuperKingdom	Isolation Part	Collection Location	Collection Time	Reference
NPO64916	Catharanthus roseus + Fusarium oxysporum symbiont	Species	n.a.	n.a.	n.a.	n.a.	n.a.	PMID[ 24066024]
NPO64872	Catharanthus roseus + Talaromyces radicus symbiont	Species	n.a.	n.a.	n.a.	n.a.	n.a.	PMID[ 26697875]
NPO64694	Catharanthus roseus + Eutypella spp. symbiont	Species	n.a.	n.a.	n.a.	n.a.	n.a.	PMID[ 27550200]
NPO64890	Nerium indicum + Geomyces sp. symbiont	Species	n.a.	n.a.	n.a.	n.a.	n.a.	PMID[ 27664729]
NPO5881	Catharanthus roseus	Species	Apocynaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[ 3619437]
NPO5881	Catharanthus roseus	Species	Apocynaceae	Eukaryota	n.a.	n.a.	n.a.	DOI[10.1002/btpr.97]
NPO5881	Catharanthus roseus	Species	Apocynaceae	Eukaryota	n.a.	n.a.	n.a.	DOI[10.1007/s11738-010-0631-6]
NPO6232	Streptomyces griseus	Species	Streptomycetaceae	Bacteria	n.a.	n.a.	n.a.	DOI[10.1016/j.biotechadv.2015.06.003]
NPO5881	Catharanthus roseus	Species	Apocynaceae	Eukaryota	n.a.	n.a.	n.a.	DOI[10.1016/j.plaphy.2018.10.015]
NPO5881	Catharanthus roseus	Species	Apocynaceae	Eukaryota	n.a.	n.a.	n.a.	DOI[10.1080/17429145.2017.1293852]
NPO5881	Catharanthus roseus	Species	Apocynaceae	Eukaryota	n.a.	n.a.	n.a.	DOI[10.1186/1750-2187-3-9]
NPO6232	Streptomyces griseus	Species	Streptomycetaceae	Bacteria	n.a.	n.a.	n.a.	PMID[11551769]
NPO5881	Catharanthus roseus	Species	Apocynaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[12628396]
NPO6232	Streptomyces griseus	Species	Streptomycetaceae	Bacteria	n.a.	n.a.	n.a.	PMID[1593278]
NPO6232	Streptomyces griseus	Species	Streptomycetaceae	Bacteria	n.a.	n.a.	n.a.	PMID[18232659]
NPO5881	Catharanthus roseus	Species	Apocynaceae	Eukaryota	Hairy roots	n.a.	n.a.	PMID[19271765]
NPO6232	Streptomyces griseus	Species	Streptomycetaceae	Bacteria	n.a.	n.a.	n.a.	PMID[21693706]
NPO6232	Streptomyces griseus	Species	Streptomycetaceae	Bacteria	n.a.	n.a.	n.a.	PMID[21939253]
NPO6232	Streptomyces griseus	Species	Streptomycetaceae	Bacteria	n.a.	n.a.	n.a.	PMID[22101040]
NPO40571	Mycoleptodiscus sp. F0194	Strain	Muyocopronaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[23560689]
NPO6232	Streptomyces griseus	Species	Streptomycetaceae	Bacteria	n.a.	n.a.	n.a.	PMID[25730866]
NPO5881	Catharanthus roseus	Species	Apocynaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[26285573]
NPO6232	Streptomyces griseus	Species	Streptomycetaceae	Bacteria	n.a.	n.a.	n.a.	PMID[5447649]
NPO5881	Catharanthus roseus	Species	Apocynaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[6619887]
NPO5881	Catharanthus roseus	Species	Apocynaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[6631435]
NPO5881	Catharanthus roseus	Species	Apocynaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[7264679]
NPO5881	Catharanthus roseus	Species	Apocynaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[7264682]
NPO32778	catharanthus trichophyllus	Species	Apocynaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[7264682]
NPO5881	Catharanthus roseus	Species	Apocynaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[7320741]
NPO32727	peschiera laeta	Species	n.a.	n.a.	n.a.	n.a.	n.a.	PMID[7853002]
NPO6232	Streptomyces griseus	Species	Streptomycetaceae	Bacteria	n.a.	n.a.	n.a.	PMID[809439]
NPO5881	Catharanthus roseus	Species	Apocynaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO6232	Streptomyces griseus	Species	Streptomycetaceae	Bacteria	n.a.	n.a.	n.a.	Database[COCONUT]
NPO5881	Catharanthus roseus	Species	Apocynaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO6232	Streptomyces griseus	Species	Streptomycetaceae	Bacteria	n.a.	n.a.	n.a.	Database[TCMID]
NPO5881	Catharanthus roseus	Species	Apocynaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO5881	Catharanthus roseus	Species	Apocynaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO6232	Streptomyces griseus	Species	Streptomycetaceae	Bacteria	n.a.	n.a.	n.a.	Database[UNPD]
NPO5881	Catharanthus roseus	Species	Apocynaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]

Note for Reference:
In addition to directly collecting NP source organism data from primary literature (where reference will provided as NCBI PMID or DOI links), NPASS also integrated them from below databases:
☉ UNPD: Universal Natural Products Database [PMID: 23638153].
☉ StreptomeDB: a database of streptomycetes natural products [PMID: 33051671].
☉ TM-MC: a database of medicinal materials and chemical compounds in Northeast Asian traditional medicine [PMID: 26156871].
☉ TCM@Taiwan: a Traditional Chinese Medicine database [PMID: 21253603].
☉ TCMID: a Traditional Chinese Medicine database [PMID: 29106634].
☉ TCMSP: The traditional Chinese medicine systems pharmacology database and analysis platform [PMID: 24735618].
☉ HerDing: a herb recommendation system to treat diseases using genes and chemicals [PMID: 26980517].
☉ MetaboLights: a metabolomics database [PMID: 27010336].
☉ FooDB: a database of constituents, chemistry and biology of food species [www.foodb.ca].

NP Quantity Composition/Concentration

Organism ID	Organism Name	Organism Material Preparation	Organism Part	NP Quantity (Standard)	NP Quantity (Minimum)	NP Quantity (Maximum)	Quantity Unit	Reference

Note for Reference:
In addition to directly collecting NP quantitative data from primary literature (where reference will provided as NCBI PMID or DOI links), NPASS also integrated NP quantitative records for specific NP domains (e.g., NPS from foods or herbs) from domain-specific databases. These databases include:
☉ DUKE: Dr. Duke's Phytochemical and Ethnobotanical Databases.
☉ PHENOL EXPLORER: is the first comprehensive database on polyphenol content in foods [PMID: 24103452], its homepage can be accessed at here.
☉ FooDB: a database of constituents, chemistry and biology of food species [www.foodb.ca].

Biological Activity

Activity Type	# Activity
Ki	12
IC50	954
Inhibition	19
Activity	91
Ratio	8
Binding site fraction	1
Log 1/Km	1
EC50	31
Potency	18
Ratio_Papp	1
Ratio_ATPase activity	1
% maximum response	1
Kd	1
AC50	59
ILS	30
ED	1
T/C	4
Log CR	2
Relative IC50	9
Reduction	6
GI50	61
TGI	20
LTS	1
Ratio IC50	47
ED50	27
IZ	8
HepSE_bilirubinemia	1
HepSE_cholecystitis	1
HepSE_cholelithiasis	1
HepSE_cirrhosis	1
HepSE_hepatic failure	1
HepSE_hepatic necrosis	1
HepSE_hepatomegaly	1
HepSE_jaundice	2
HepSE_liver fatty	1
HepSE_liver function tests abnormal	1
HepSE_Combined Scores	1
GI	1
Hepatotoxicity (acute)	1
RatioGI50	2
EC	3
Hit score	1
TC50	1
HepSE_liver disease	1
Hepatotoxicity (moderate)	2
Hepatotoxicity (granulomatous hepatitis)	1
Hepatotoxicity (benign tumour)	1
Log kill	14
Survival days	2
Survival	1
Survivors	49
HepSE_elevated liver function tests	1
HepSE_hepatitis	1
ALT	6
ALB	6
ALP	6
AST	6
BUN	6
CO2	6
CHLORIDE	6
CHOL	6
CK	6
CREAT	6
GLUC	6
LDH	6
LIPASE	6
PHOS	6
POTASSIUM	6
SODIUM	6
BILI	6
PROT	6
URATE	6
BASO	6
EOS	6
LYM	6
MONO	6
NEUTSG	6
BASOLE	6
EOSLE	6
RBC	6
HCT	6
HGB	6
WBC	6
LYMLE	6
MCH	6
MCHC	6
MCV	6
MONOLE	6
NEUTLE	6
RBCNUC	6
PLAT	6
Fg	1
F_fraction	1
Fa	1
Fabs	1

Activity Type	# Activity
Individual protein	137
Cell line	1058
Protein family	9
Protein complex	4
Organism	344
Nucleic acid	2
Protein-protein interaction	1
Single protein	1
Non-molecular	125
Others	44
Phenotype	15

Molecular-level activity

Target ID	Target Type	Target Name	Target Organism	Activity Type	Activity Relation	Value	Unit	Reference
NPT109	Individual protein	Cytochrome P450 3A4	Homo sapiens	IC50	=	26000.0	nM	PMID[18980381]
NPT1455	Individual protein	P-glycoprotein 3	Mus musculus	IC50	>	50000.0	nM	PMID[19555122]
NPT1456	Individual protein	P-glycoprotein 1	Mus musculus	IC50	=	8000.0	nM	PMID[19555122]
NPT1455	Individual protein	P-glycoprotein 3	Mus musculus	Ratio	=	3.0	n.a.	PMID[19555122]
NPT1455	Individual protein	P-glycoprotein 3	Mus musculus	Ratio	=	5.2	n.a.	PMID[19555122]
NPT1455	Individual protein	P-glycoprotein 3	Mus musculus	Ratio	=	4.3	n.a.	PMID[19555122]
NPT2698	Individual protein	Beta tubulin	Leishmania donovani	IC50	=	1000.0	nM	PMID[18498150]
NPT109	Individual protein	Cytochrome P450 3A4	Homo sapiens	Log 1/Km	=	-0.834	n.a.	PMID[15990295]
NPT198	Individual protein	Vitamin D receptor	Homo sapiens	Potency	n.a.	44668.4	nM	DrugMatrix in vitro pharmacology data
NPT154	Individual protein	Mothers against decapentaplegic homolog 3	Homo sapiens	Potency	n.a.	11220.2	nM	PMID[20350811]
NPT257	Individual protein	Arachidonate 15-lipoxygenase	Oryctolagus cuniculus	IC50	=	5037.0	nM	PMID[23806110]
NPT300	Individual protein	Thromboxane-A synthase	Homo sapiens	IC50	=	1870.0	nM	PubChem BioAssay data set
NPT304	Individual protein	Canalicular multispecific organic anion transporter 1	Rattus norvegicus	Activity	=	29.0	%	PMID[23823011]
NPT1594	Individual protein	Multidrug resistance-associated protein 1	Homo sapiens	IC50	=	30000.0	nM	PMID[17132069]
NPT10	Individual protein	Geminin	Homo sapiens	Potency	n.a.	5.3	nM	PMID[17582775]
NPT10	Individual protein	Geminin	Homo sapiens	Potency	n.a.	749.9	nM	PMID[10579873]
NPT1853	Individual protein	Putative uncharacterized protein	Trypanosoma brucei brucei (strain 927/4 GUTat10.1)	Potency	n.a.	31622.8	nM	PMID[10560729]
NPT242	Individual protein	Dopamine D1 receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT262	Individual protein	Muscarinic acetylcholine receptor M1	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT30	Individual protein	Cyclooxygenase-1	Homo sapiens	AC50	=	9251.9	nM	PMID[37468498]
NPT263	Individual protein	Muscarinic acetylcholine receptor M2	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT1788	Individual protein	Alpha-1a adrenergic receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT218	Individual protein	Adenosine A3 receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT145	Individual protein	Mu opioid receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT295	Individual protein	Serotonin transporter	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT204	Individual protein	Acetylcholinesterase	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT153	Individual protein	Androgen Receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT108	Individual protein	Estrogen receptor alpha	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT246	Individual protein	Dopamine transporter	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT222	Individual protein	Alpha-2a adrenergic receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT228	Individual protein	Norepinephrine transporter	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT261	Individual protein	Monoamine oxidase A	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT216	Individual protein	Adenosine A1 receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT2769	Individual protein	Thromboxane A2 receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT291	Individual protein	Serotonin 2b (5-HT2b) receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT1410	Individual protein	GABA receptor alpha-1 subunit	Rattus norvegicus	AC50	>	30000.0	nM	PMID[37468498]
NPT2761	Individual protein	Phosphodiesterase 4A	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT30	Individual protein	Cyclooxygenase-1	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT30	Individual protein	Cyclooxygenase-1	Homo sapiens	AC50	=	26870.1	nM	PMID[37468498]
NPT30	Individual protein	Cyclooxygenase-1	Homo sapiens	AC50	=	623.8	nM	PMID[37468498]
NPT244	Individual protein	Dopamine D3 receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT782	Protein family	Tubulin	Bos taurus	IC50	=	700.0	nM	PMID[9249970]
NPT781	Individual protein	Tubulin alpha chain	Sus scrofa	Inhibition	=	64.0	%	PMID[16378378]
NPT679	Individual protein	Monoamine oxidase B	Bos taurus	Ki	=	77000.0	nM	PMID[17870539]
NPT613	Individual protein	Solute carrier family 22 member 1	Homo sapiens	Inhibition	=	1.9	%	DrugMatrix in vitro pharmacology data
NPT531	Individual protein	Nuclear receptor ROR-gamma	Mus musculus	Potency	=	11220.2	nM	PMID[24613164]
NPT713	Individual protein	Bile salt export pump	Homo sapiens	IC50	=	114700.0	nM	PMID[23398362]
NPT713	Individual protein	Bile salt export pump	Homo sapiens	IC50	=	62000.0	nM	PMID[19651906]
NPT72	Individual protein	Solute carrier organic anion transporter family member 1B3	Homo sapiens	Inhibition	=	54.3	%	PMID[17243726]
NPT72	Individual protein	Solute carrier organic anion transporter family member 1B3	Homo sapiens	Ki	=	18600.0	nM	PMID[25302529]
NPT72	Individual protein	Solute carrier organic anion transporter family member 1B3	Homo sapiens	IC50	=	43500.0	nM	DrugMatrix in vitro pharmacology data
NPT72	Individual protein	Solute carrier organic anion transporter family member 1B3	Homo sapiens	Inhibition	=	81.5	%	DrugMatrix in vitro pharmacology data
NPT782	Protein family	Tubulin	Bos taurus	IC50	=	600.0	nM	PMID[19451299]
NPT987	Individual protein	Histamine H3 receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT3597	Individual protein	Tubulin beta chain	Bos taurus	Ki	>	100000.0	nM	PMID[22703109]
NPT317	Nucleic acid	Nucleic Acid	n.a.	Activity	=	100.0	%	PMID[23701597]
NPT612	Individual protein	Canalicular multispecific organic anion transporter 1	Homo sapiens	Activity	=	78.0	%	PubChem BioAssay data set
NPT7	Individual protein	Thioredoxin reductase 1, cytoplasmic	Rattus norvegicus	Potency	n.a.	11220.2	nM	Open TG-GATES in vivo data: Hematology
NPT444	Individual protein	Ubiquitin carboxyl-terminal hydrolase 1	Homo sapiens	Potency	n.a.	56234.1	nM	PMID[17261619]
NPT612	Individual protein	Canalicular multispecific organic anion transporter 1	Homo sapiens	IC50	=	21000.0	nM	PMID[18321710]
NPT73	Individual protein	Solute carrier organic anion transporter family member 1B1	Homo sapiens	Inhibition	=	57.6	%	DOI[10.1039/C5MD00346F]
NPT73	Individual protein	Solute carrier organic anion transporter family member 1B1	Homo sapiens	Ki	=	10200.0	nM	PMID[2089117]
NPT73	Individual protein	Solute carrier organic anion transporter family member 1B1	Homo sapiens	Inhibition	=	64.1	%	PMID[19596573]
NPT73	Individual protein	Solute carrier organic anion transporter family member 1B1	Homo sapiens	IC50	=	46800.0	nM	PubChem BioAssay data set
NPT20556	Single protein	Replicase polyprotein 1ab	Severe acute respiratory syndrome coronavirus 2	Inhibition	=	11.78	%	DOI[10.6019/CHEMBL4495564]
NPT542	Individual protein	Progesterone receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT3014	Protein family	Tubulin	Sus scrofa	IC50	=	600.0	nM	PubChem BioAssay data set
NPT518	Protein complex	Tubulin	Homo sapiens	IC50	=	70.0	nM	PMID[17383189]
NPT518	Protein complex	Tubulin	Homo sapiens	IC50	=	300.0	nM	PMID[17249727]
NPT518	Protein complex	Tubulin	Homo sapiens	EC50	=	200.0	nM	PMID[10924166]
NPT459	Individual protein	Human immunodeficiency virus type 1 reverse transcriptase	Human immunodeficiency virus 1	IC50	>	200.0	ug.mL-1	PMID[1710653]
NPT3014	Protein family	Tubulin	Sus scrofa	IC50	=	1600.0	nM	DrugMatrix in vitro pharmacology data
NPT8	Individual protein	DNA polymerase iota	Homo sapiens	Potency	n.a.	44668.4	nM	PMID[19783432]
NPT445	Individual protein	Peripheral myelin protein 22	Rattus norvegicus	Potency	n.a.	223.7	nM	PMID[19845338]
NPT445	Individual protein	Peripheral myelin protein 22	Rattus norvegicus	Potency	n.a.	720.8	nM	PMID[22037378]
NPT622	Individual protein	Solute carrier organic anion transporter family member 2B1	Homo sapiens	Inhibition	=	-9.3	%	DrugMatrix in vitro pharmacology data
NPT3014	Protein family	Tubulin	Sus scrofa	Inhibition	=	50.0	%	PMID[7130986]
NPT3014	Protein family	Tubulin	Sus scrofa	Activity	=	50.0	%	PMID[23755850]
NPT518	Protein complex	Tubulin	Homo sapiens	IC50	=	2100.0	nM	PMID[21840711]
NPT3014	Protein family	Tubulin	Sus scrofa	IC50	=	1100.0	nM	Open TG-GATES in vivo data: Hematology
NPT3014	Protein family	Tubulin	Sus scrofa	Inhibition	=	73.93	%	PMID[21855182]
NPT92	Individual protein	Serotonin 1a (5-HT1a) receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT5104	Individual protein	Phosphodiesterase 3A	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT668	Individual protein	P-glycoprotein 1	Homo sapiens	Activity	=	33.0	nM/mg*min	PMID[19555122]
NPT668	Individual protein	P-glycoprotein 1	Homo sapiens	Inhibition	=	75.0	%	PMID[19555122]
NPT668	Individual protein	P-glycoprotein 1	Homo sapiens	IC50	=	2000.0	nM	PMID[19555122]
NPT668	Individual protein	P-glycoprotein 1	Homo sapiens	IC50	>	50000.0	nM	PMID[19555122]
NPT668	Individual protein	P-glycoprotein 1	Homo sapiens	Ki	=	100.0	nM	PMID[24063582]
NPT668	Individual protein	P-glycoprotein 1	Homo sapiens	Binding site fraction	=	0.4	n.a.	PMID[12477351]
NPT668	Individual protein	P-glycoprotein 1	Homo sapiens	IC50	=	34000.0	nM	PMID[24063582]
NPT668	Individual protein	P-glycoprotein 1	Homo sapiens	Ki	=	1300.0	nM	PMID[24063582]
NPT668	Individual protein	P-glycoprotein 1	Homo sapiens	IC50	=	10000.0	nM	PMID[25856683]
NPT668	Individual protein	P-glycoprotein 1	Homo sapiens	IC50	=	10471.29	nM	PMID[20483615]
NPT668	Individual protein	P-glycoprotein 1	Homo sapiens	Activity	=	4.5	uM	PMID[17848563]
NPT668	Individual protein	P-glycoprotein 1	Homo sapiens	Activity	=	42.0	uM	PMID[17848563]
NPT668	Individual protein	P-glycoprotein 1	Homo sapiens	Activity	=	1.2	uM	PMID[17848563]
NPT1881	Nucleic acid	Calf thymus DNA	Bos taurus	Activity	>	70.0	%	PMID[26707398]
NPT6402	Individual protein	Tubulin beta-5 chain	Homo sapiens	Activity	=	25.0	%	PMID[6481359]
NPT668	Individual protein	P-glycoprotein 1	Homo sapiens	Activity	=	35.0	%	PMID[24328269]
NPT668	Individual protein	P-glycoprotein 1	Homo sapiens	Activity	=	31.0	%	PMID[24035341]
NPT197	Protein-protein interaction	Menin/Histone-lysine N-methyltransferase MLL	Homo sapiens	Potency	=	35481.3	nM	PMID[26722868]
NPT5	Individual protein	Histone-lysine N-methyltransferase, H3 lysine-9 specific 3	Homo sapiens	Potency	n.a.	3162.3	nM	PMID[19253982]
NPT668	Individual protein	P-glycoprotein 1	Homo sapiens	Ratio_Papp	>	23.0	n.a.	PMID[11602674]
NPT668	Individual protein	P-glycoprotein 1	Homo sapiens	Ratio_ATPase activity	=	4.31	n.a.	PMID[11602674]
NPT668	Individual protein	P-glycoprotein 1	Homo sapiens	% maximum response	=	24.4	%	PMID[11602674]
NPT668	Individual protein	P-glycoprotein 1	Homo sapiens	Activity	=	44.0	%	PMID[15921415]
NPT668	Individual protein	P-glycoprotein 1	Homo sapiens	Activity	=	75.0	%	PMID[21761866]
NPT668	Individual protein	P-glycoprotein 1	Homo sapiens	EC50	=	14600.0	nM	PMID[23434420]
NPT668	Individual protein	P-glycoprotein 1	Homo sapiens	EC50	=	34000.0	nM	PMID[23434420]
NPT668	Individual protein	P-glycoprotein 1	Homo sapiens	IC50	=	17700.0	nM	PMID[25129171]
NPT668	Individual protein	P-glycoprotein 1	Homo sapiens	IC50	=	19900.0	nM	PMID[23316950]
NPT668	Individual protein	P-glycoprotein 1	Homo sapiens	IC50	=	29500.0	nM	PubChem BioAssay data set
NPT668	Individual protein	P-glycoprotein 1	Homo sapiens	IC50	=	29000.0	nM	PMID[11374943]
NPT668	Individual protein	P-glycoprotein 1	Homo sapiens	Kd	=	3000.0	nM	PMID[15104495]
NPT668	Individual protein	P-glycoprotein 1	Homo sapiens	Ki	=	140000.0	nM	PMID[19835393]
NPT668	Individual protein	P-glycoprotein 1	Homo sapiens	Ki	=	15000.0	nM	PubChem BioAssay data set
NPT668	Individual protein	P-glycoprotein 1	Homo sapiens	Ki	=	2100.0	nM	PMID[26213786]
NPT668	Individual protein	P-glycoprotein 1	Homo sapiens	Ki	=	36500.0	nM	PMID[23558238]
NPT670	Individual protein	Thrombin	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]

In vitro activity

Target ID	Target Type	Target Name	Target Organism	Activity Type	Activity Relation	Value	Unit	Reference
NPT2182	Cell line	Mo	Homo sapiens	IC50	=	880.24	nM	PMID[21401115]
NPT378	Cell line	NCI/ADR-RES	Homo sapiens	IC50	=	3900.0	ug.mL-1	PMID[23501116]
NPT168	Cell line	P388	Mus musculus	IC50	=	1.7	nM	DOI[10.1007/s00044-007-9020-0]
NPT168	Cell line	P388	Mus musculus	IC50	=	8.2	nM	PMID[22122518]
NPT168	Cell line	P388	Mus musculus	ILS	~	50.0	%	DOI[10.1016/S0960-894X(00)80225-5]
NPT168	Cell line	P388	Mus musculus	ILS	~	100.0	%	DOI[10.1016/S0960-894X(00)80225-5]
NPT165	Cell line	HeLa	Homo sapiens	ED	=	0.0015	ug ml-1	PubChem BioAssay data set
NPT137	Cell line	L1210	Mus musculus	T/C	=	140.0	%	PMID[2362275]
NPT319	Cell line	B16	Mus musculus	T/C	=	180.0	%	PMID[2362275]
NPT404	Cell line	CCRF-CEM	Homo sapiens	Log CR	=	1.28	n.a.	PMID[2362268]
NPT1161	Cell line	CHO	Cricetulus griseus	Log CR	=	1.46	n.a.	PMID[2362268]
NPT1886	Cell line	J774	Mus musculus	IC50	=	2.1	nM	PMID[16499322]
NPT1597	Cell line	J774.2	n.a.	IC50	=	15.9	nM	PMID[16499322]
NPT1597	Cell line	J774.2	n.a.	IC50	=	0.8	nM	PMID[16499322]
NPT1597	Cell line	J774.2	n.a.	Activity	=	90.9	pM of drug (10e6*cells)-1	PMID[25739048]
NPT1597	Cell line	J774.2	n.a.	Activity	=	163.3	pM of drug (10e6*cells)-1	PMID[23398362]
NPT148	Cell line	HCT-15	Homo sapiens	IC50	=	43.0	nM	PMID[22703109]
NPT397	Cell line	NCI-H460	Homo sapiens	IC50	=	3.4	nM	PMID[22703109]
NPT1178	Cell line	KB 3-1	Homo sapiens	Relative IC50	=	1.0	nM	PMID[8632413]
NPT91	Cell line	KB	Homo sapiens	Relative IC50	=	2000.0	nM	PMID[8632413]
NPT91	Cell line	KB	Homo sapiens	Relative IC50	=	1.3	nM	PMID[8632413]
NPT83	Cell line	MCF7	Homo sapiens	Relative IC50	=	1.0	nM	PMID[8632413]
NPT83	Cell line	MCF7	Homo sapiens	Relative IC50	=	17500.0	nM	PMID[8632413]
NPT83	Cell line	MCF7	Homo sapiens	Relative IC50	=	0.5	nM	PMID[8632413]
NPT168	Cell line	P388	Mus musculus	Relative IC50	=	1.0	nM	PMID[8632413]
NPT168	Cell line	P388	Mus musculus	Relative IC50	=	19.0	nM	PMID[8632413]
NPT168	Cell line	P388	Mus musculus	Relative IC50	=	0.2	nM	PMID[8632413]
NPT1396	Cell line	NCI-H69	Homo sapiens	Reduction	~	88.0	%	PMID[15012986]
NPT1396	Cell line	NCI-H69	Homo sapiens	Reduction	~	94.0	%	PMID[15012986]
NPT1396	Cell line	NCI-H69	Homo sapiens	Reduction	~	95.0	%	PMID[15012986]
NPT1396	Cell line	NCI-H69	Homo sapiens	Reduction	=	0.0	%	PMID[15012986]
NPT681	Cell line	PC-12	Rattus norvegicus	GI50	=	0.0102	ug.mL-1	PubChem BioAssay data set
NPT393	Cell line	HCT-116	Homo sapiens	GI50	=	0.001	ug.mL-1	PMID[11374954]
NPT5516	Cell line	EBV-positive nasopharyngealcell lines	n.a.	Reduction	>	99.0	%	PMID[6685770]
NPT83	Cell line	MCF7	Homo sapiens	GI50	=	2.3	nM	PMID[10514324]
NPT378	Cell line	NCI/ADR-RES	Homo sapiens	GI50	=	350.0	nM	PMID[22168134]
NPT168	Cell line	P388	Mus musculus	GI50	=	4.1	nM	PMID[20430633]
NPT552	Cell line	P388/ADR	Mus musculus	GI50	=	470.0	nM	PMID[20430633]
NPT404	Cell line	CCRF-CEM	Homo sapiens	GI50	=	0.02	nM	PMID[22212722]
NPT112	Cell line	MOLT-4	Homo sapiens	GI50	<	0.25	nM	PMID[17822300]
NPT708	Cell line	HuT78	Homo sapiens	GI50	<	0.25	nM	PMID[17822300]
NPT389	Cell line	RPMI-8226	Homo sapiens	GI50	=	0.003	nM	PMID[17822300]
NPT111	Cell line	K562	Homo sapiens	GI50	<	0.25	nM	PMID[23373965]
NPT116	Cell line	HL-60	Homo sapiens	GI50	=	0.036	nM	PMID[15104488]
NPT404	Cell line	CCRF-CEM	Homo sapiens	TGI	=	1.91	nM	PMID[11473443]
NPT112	Cell line	MOLT-4	Homo sapiens	TGI	<	0.25	nM	PMID[11473443]
NPT708	Cell line	HuT78	Homo sapiens	TGI	<	0.25	nM	PMID[17822300]
NPT389	Cell line	RPMI-8226	Homo sapiens	TGI	=	0.8	nM	PMID[17822300]
NPT111	Cell line	K562	Homo sapiens	TGI	<	0.25	nM	PubChem BioAssay data set
NPT116	Cell line	HL-60	Homo sapiens	TGI	=	0.25	nM	PubChem BioAssay data set
NPT82	Cell line	MDA-MB-231	Homo sapiens	IC50	=	11.0	nM	PMID[20937542]
NPT404	Cell line	CCRF-CEM	Homo sapiens	IC50	=	0.1	ug.mL-1	PMID[2045815]
NPT189	Cell line	Vero	Chlorocebus aethiops	EC50	<	3700.0	nM	PMID[25695368]
NPT3871	Cell line	N592	n.a.	IC50	=	4.0	nM	PMID[23462643]
NPT137	Cell line	L1210	Mus musculus	IC50	=	3.15	nM	PMID[19128055]
NPT168	Cell line	P388	Mus musculus	T/C	=	157.0	%	PMID[2066973]
NPT168	Cell line	P388	Mus musculus	LTS	=	2.0	n.a.	PMID[2066973]
NPT404	Cell line	CCRF-CEM	Homo sapiens	IC50	=	1.2	nM	PMID[21476569]
NPT81	Cell line	A549	Homo sapiens	IC50	=	9.9	nM	PMID[21476569]
NPT393	Cell line	HCT-116	Homo sapiens	IC50	=	8.7	nM	PMID[11000021]
NPT393	Cell line	HCT-116	Homo sapiens	IC50	=	4.0	nM	PMID[18591275]
NPT111	Cell line	K562	Homo sapiens	IC50	=	3000.0	nM	PMID[26349626]
NPT111	Cell line	K562	Homo sapiens	Activity	=	33.0	%	PMID[16499322]
NPT111	Cell line	K562	Homo sapiens	Activity	=	30.0	%	PMID[18625771]
NPT111	Cell line	K562	Homo sapiens	Activity	=	37.0	%	PubChem BioAssay data set
NPT1527	Cell line	WRL68	Homo sapiens	IC50	=	1.45	ug.mL-1	PMID[20112996]
NPT83	Cell line	MCF7	Homo sapiens	IC50	=	0.22	ug.mL-1	PMID[18276144]
NPT83	Cell line	MCF7	Homo sapiens	IC50	=	0.02	ug.mL-1	PMID[16562846]
NPT1527	Cell line	WRL68	Homo sapiens	IC50	=	2.6	ug.mL-1	PMID[20439614]
NPT91	Cell line	KB	Homo sapiens	IC50	=	0.046	ug.mL-1	PMID[22413887]
NPT91	Cell line	KB	Homo sapiens	IC50	=	0.46	ug.mL-1	PMID[16933872]
NPT2400	Cell line	PA-1	Homo sapiens	IC50	=	0.025	ug.mL-1	PMID[16933872]
NPT3852	Cell line	COLO 320DM	Homo sapiens	IC50	=	0.52	ug.mL-1	PMID[16933872]
NPT2400	Cell line	PA-1	Homo sapiens	IC50	=	1.15	ug.mL-1	PMID[26091285]
NPT3852	Cell line	COLO 320DM	Homo sapiens	IC50	=	1.6	ug.mL-1	PMID[26091285]
NPT404	Cell line	CCRF-CEM	Homo sapiens	IC50	=	0.4	nM	PMID[11170658]
NPT404	Cell line	CCRF-CEM	Homo sapiens	IC50	=	28.7	nM	PMID[25646964]
NPT404	Cell line	CCRF-CEM	Homo sapiens	IC50	=	206.6	nM	PMID[13678412]
NPT81	Cell line	A549	Homo sapiens	IC50	=	1.1	nM	PMID[11000030]
NPT393	Cell line	HCT-116	Homo sapiens	IC50	=	0.7	nM	PMID[2016726]
NPT3881	Cell line	MX1	Homo sapiens	IC50	=	2.0	nM	PMID[26210507]
NPT139	Cell line	HT-29	Homo sapiens	EC50	=	2.0	nM	PMID[18299417]
NPT83	Cell line	MCF7	Homo sapiens	EC50	=	3.0	nM	PMID[18505859]
NPT111	Cell line	K562	Homo sapiens	EC50	=	1.0	nM	PMID[25136754]
NPT492	Cell line	Caco-2	Homo sapiens	Activity	=	81.0	%	PMID[20421401]
NPT492	Cell line	Caco-2	Homo sapiens	Activity	=	72.0	%	PMID[20421401]
NPT492	Cell line	Caco-2	Homo sapiens	Activity	=	42.0	%	PMID[20421401]
NPT400	Cell line	MDA-MB-435	Homo sapiens	IC50	=	4.4	nM	PMID[26110443]
NPT168	Cell line	P388	Mus musculus	Ratio IC50	=	22.0	n.a.	PMID[11087594]
NPT400	Cell line	MDA-MB-435	Homo sapiens	IC50	=	0.34	nM	PMID[19128055]
NPT552	Cell line	P388/ADR	Mus musculus	IC50	=	95.0	nM	PMID[12027740]
NPT552	Cell line	P388/ADR	Mus musculus	IC50	=	4.3	nM	PMID[23634786]
NPT400	Cell line	MDA-MB-435	Homo sapiens	Ratio IC50	=	15.0	n.a.	PMID[23634786]
NPT400	Cell line	MDA-MB-435	Homo sapiens	Ratio IC50	=	10.0	n.a.	PMID[23634786]
NPT400	Cell line	MDA-MB-435	Homo sapiens	IC50	=	0.29	nM	PMID[19348465]
NPT400	Cell line	MDA-MB-435	Homo sapiens	IC50	=	0.42	nM	PMID[21106374]
NPT168	Cell line	P388	Mus musculus	IC50	=	4.1	nM	PMID[21106374]
NPT148	Cell line	HCT-15	Homo sapiens	IC50	=	79.4	nM	PMID[17253840]
NPT369	Cell line	ACHN	Homo sapiens	IC50	=	25.0	nM	PMID[22260166]
NPT1396	Cell line	NCI-H69	Homo sapiens	IC50	=	1.6	nM	PMID[22409377]
NPT404	Cell line	CCRF-CEM	Homo sapiens	IC50	=	4.0	nM	Open TG-GATES in vivo data: Hematology
NPT404	Cell line	CCRF-CEM	Homo sapiens	Ratio IC50	=	89.0	n.a.	PMID[17190447]
NPT404	Cell line	CCRF-CEM	Homo sapiens	Ratio IC50	=	2.0	n.a.	PMID[3373220]
NPT396	Cell line	T47D	Homo sapiens	EC50	=	25.0	nM	PMID[8864235]
NPT2410	Cell line	NCI-H1299	Homo sapiens	EC50	=	73.0	nM	PMID[15566300]
NPT579	Cell line	DLD-1	Homo sapiens	EC50	=	129.0	nM	PMID[26241103]
NPT81	Cell line	A549	Homo sapiens	EC50	=	0.9	nM	DrugMatrix in vitro pharmacology data
NPT81	Cell line	A549	Homo sapiens	EC50	=	0.5	nM	Open TG-GATES in vivo data: Hematology
NPT139	Cell line	HT-29	Homo sapiens	GI50	=	2.0	nM	PMID[11678661]
NPT2815	Cell line	M21	Homo sapiens	GI50	=	10.0	nM	PMID[20100877]
NPT83	Cell line	MCF7	Homo sapiens	GI50	=	2.0	nM	PMID[25237727]
NPT83	Cell line	MCF7	Homo sapiens	IC50	=	2.8	nM	PMID[6690686]
NPT116	Cell line	HL-60	Homo sapiens	Activity	=	83.3	%	PMID[15027854]
NPT116	Cell line	HL-60	Homo sapiens	Activity	=	6.6	%	PMID[15165136]
NPT116	Cell line	HL-60	Homo sapiens	Activity	=	10.1	%	PMID[15165136]
NPT466	Cell line	U-937	Homo sapiens	IC50	=	6880.0	nM	PMID[21982797]
NPT179	Cell line	A2780	Homo sapiens	IC50	=	61.66	nM	PMID[24087924]
NPT396	Cell line	T47D	Homo sapiens	EC50	=	43.0	nM	PMID[23227781]
NPT393	Cell line	HCT-116	Homo sapiens	EC50	=	44.0	nM	PMID[20937542]
NPT4783	Cell line	SNU-398	Homo sapiens	EC50	=	38.0	nM	PubChem BioAssay data set
NPT396	Cell line	T47D	Homo sapiens	GI50	=	7.0	nM	PMID[24269513]
NPT389	Cell line	RPMI-8226	Homo sapiens	IC50	=	28.0	nM	PMID[19514743]
NPT1178	Cell line	KB 3-1	Homo sapiens	IC50	=	9271000.0	nM	PMID[18313307]
NPT65	Cell line	HepG2	Homo sapiens	IC50	=	0.07	nM	PMID[24582402]
NPT65	Cell line	HepG2	Homo sapiens	IC50	=	440.0	nM	PMID[18183025]
NPT111	Cell line	K562	Homo sapiens	IC50	=	0.88	nM	PMID[24582402]
NPT65	Cell line	HepG2	Homo sapiens	IC50	=	5946000.0	nM	PMID[24582402]
NPT111	Cell line	K562	Homo sapiens	IC50	=	170.0	nM	PMID[20553004]
NPT111	Cell line	K562	Homo sapiens	IC50	=	193000.0	nM	PMID[18183025]
NPT400	Cell line	MDA-MB-435	Homo sapiens	IC50	=	0.27	nM	PMID[25856683]
NPT139	Cell line	HT-29	Homo sapiens	IC50	=	0.53	nM	PMID[25856683]
NPT466	Cell line	U-937	Homo sapiens	IC50	=	0.49	nM	PMID[25856683]
NPT319	Cell line	B16	Mus musculus	IC50	=	3.6	ug.mL-1	PMID[25260957]
NPT91	Cell line	KB	Homo sapiens	IC50	=	1.0	nM	PMID[22939698]
NPT762	Cell line	A-431	Homo sapiens	ED50	=	0.05	ug ml-1	PMID[16933872]
NPT1851	Cell line	Col2	Homo sapiens	ED50	=	0.01	ug ml-1	Open TG-GATES in vivo data: Hematology
NPT2049	Cell line	HT	Homo sapiens	ED50	=	0.02	ug ml-1	DrugMatrix in vitro pharmacology data
NPT91	Cell line	KB	Homo sapiens	ED50	=	0.002	ug ml-1	PMID[18341287]
NPT858	Cell line	LNCaP	Homo sapiens	ED50	=	0.1	ug ml-1	DrugMatrix in vitro pharmacology data
NPT1034	Cell line	Lu1	Homo sapiens	ED50	=	0.02	ug ml-1	Open TG-GATES in vivo data: Hematology
NPT147	Cell line	SK-MEL-2	Homo sapiens	ED50	=	0.01	ug ml-1	DrugMatrix in vitro pharmacology data
NPT168	Cell line	P388	Mus musculus	ED50	=	0.02	ug ml-1	PMID[16499318]
NPT133	Cell line	ZR-75-1	Homo sapiens	ED50	=	0.3	ug ml-1	PMID[23398362]
NPT579	Cell line	DLD-1	Homo sapiens	GI50	<	10.0	nM	DrugMatrix in vivo data: Biochemistry
NPT579	Cell line	DLD-1	Homo sapiens	TGI	=	2440.0	nM	DrugMatrix in vivo data: Biochemistry
NPT395	Cell line	SF-268	Homo sapiens	GI50	<	10.0	nM	DrugMatrix in vivo data: Hematology
NPT395	Cell line	SF-268	Homo sapiens	TGI	=	1640.0	nM	DrugMatrix in vivo data: Hematology
NPT83	Cell line	MCF7	Homo sapiens	GI50	<	10.0	nM	PMID[24893224]
NPT83	Cell line	MCF7	Homo sapiens	TGI	=	1600.0	nM	PMID[24893224]
NPT397	Cell line	NCI-H460	Homo sapiens	GI50	<	10.0	nM	PubChem BioAssay data set
NPT397	Cell line	NCI-H460	Homo sapiens	TGI	=	350.0	nM	PMID[24893224]
NPT377	Cell line	OVCAR-3	Homo sapiens	GI50	<	10.0	nM	PMID[10346940]
NPT377	Cell line	OVCAR-3	Homo sapiens	TGI	<	10.0	nM	PMID[10346940]
NPT168	Cell line	P388	Mus musculus	ED50	=	1.7	ug ml-1	PMID[19084294]
NPT393	Cell line	HCT-116	Homo sapiens	IC50	=	3.0	nM	PMID[24461297]
NPT393	Cell line	HCT-116	Homo sapiens	IC50	=	135.0	nM	PMID[25625705]
NPT179	Cell line	A2780	Homo sapiens	IC50	=	5.0	nM	PMID[25625705]
NPT134	Cell line	SK-BR-3	Homo sapiens	IC50	=	72.0	nM	PMID[16038557]
NPT393	Cell line	HCT-116	Homo sapiens	Ratio IC50	=	45.0	n.a.	PMID[25625705]
NPT319	Cell line	B16	Mus musculus	T/C	=	309.0	%	PMID[6631435]
NPT404	Cell line	CCRF-CEM	Homo sapiens	Ratio IC50	=	679.5	n.a.	PMID[20047913]
NPT404	Cell line	CCRF-CEM	Homo sapiens	IC50	=	0.73	nM	PMID[18720971]
NPT404	Cell line	CCRF-CEM	Homo sapiens	IC50	=	78.0	nM	PMID[20230038]
NPT404	Cell line	CCRF-CEM	Homo sapiens	IC50	=	496.0	nM	PMID[8277313]
NPT3881	Cell line	MX1	Homo sapiens	IC50	=	2.9	nM	PMID[23746784]
NPT393	Cell line	HCT-116	Homo sapiens	IC50	=	1.8	nM	PMID[19128055]
NPT404	Cell line	CCRF-CEM	Homo sapiens	Ratio IC50	=	106.2	n.a.	PMID[24941130]
NPT139	Cell line	HT-29	Homo sapiens	IC50	=	4.0	nM	Open TG-GATES in vivo data: Organ Weight
NPT139	Cell line	HT-29	Homo sapiens	IZ	=	40.0	mm	PMID[14664515]
NPT139	Cell line	HT-29	Homo sapiens	IZ	=	25.0	mm	PubChem BioAssay data set
NPT139	Cell line	HT-29	Homo sapiens	IZ	=	10.0	mm	PMID[17253840]
NPT168	Cell line	P388	Mus musculus	IC50	=	0.7	nM	PMID[23398362]
NPT168	Cell line	P388	Mus musculus	IZ	>	40.0	mm	PubChem BioAssay data set
NPT168	Cell line	P388	Mus musculus	IZ	=	32.5	mm	PMID[25581396]
NPT168	Cell line	P388	Mus musculus	IZ	=	12.5	mm	DrugMatrix in vivo data: Biochemistry
NPT91	Cell line	KB	Homo sapiens	ED50	=	0.1	10'-4 ug/ml	PMID[20550196]
NPT189	Cell line	Vero	Chlorocebus aethiops	ED50	>	1.0	10'-1 ug/ml	PMID[20550196]
NPT404	Cell line	CCRF-CEM	Homo sapiens	IC50	=	0.03	ug.mL-1	PMID[23701598]
NPT165	Cell line	HeLa	Homo sapiens	ED50	>	20.0	ug ml-1	PMID[22940450]
NPT1171	Cell line	HEp-2	Homo sapiens	ED50	>	20.0	ug ml-1	PMID[18316521]
NPT91	Cell line	KB	Homo sapiens	ED50	>	20.0	ug ml-1	DrugMatrix in vitro pharmacology data
NPT65	Cell line	HepG2	Homo sapiens	IC50	=	0.26	nM	PMID[19105653]
NPT393	Cell line	HCT-116	Homo sapiens	IC50	=	1.1	nM	PMID[25707014]
NPT3881	Cell line	MX1	Homo sapiens	IC50	=	2.2	nM	PMID[17125236]
NPT91	Cell line	KB	Homo sapiens	ED50	=	0.05	ug ml-1	PMID[26034885]
NPT1171	Cell line	HEp-2	Homo sapiens	ED50	=	0.001	ug ml-1	PMID[26034885]
NPT189	Cell line	Vero	Chlorocebus aethiops	ED50	>	1.0	ug ml-1	PMID[20550196]
NPT168	Cell line	P388	Mus musculus	IC50	=	27.0	nM	PMID[26046820]
NPT168	Cell line	P388	Mus musculus	IC50	=	0.6	nM	PMID[26046820]
NPT83	Cell line	MCF7	Homo sapiens	GI50	=	0.4	nM	PMID[22758788]
NPT165	Cell line	HeLa	Homo sapiens	GI50	=	0.9	nM	PMID[15711537]
NPT4783	Cell line	SNU-398	Homo sapiens	GI50	=	5.0	nM	PMID[24269513]
NPT393	Cell line	HCT-116	Homo sapiens	GI50	=	10.0	nM	PMID[24269513]
NPT4783	Cell line	SNU-398	Homo sapiens	EC50	=	26.0	nM	PMID[24126094]
NPT396	Cell line	T47D	Homo sapiens	EC50	=	32.0	nM	PMID[24269513]
NPT393	Cell line	HCT-116	Homo sapiens	EC50	=	36.0	nM	DrugMatrix in vitro pharmacology data
NPT579	Cell line	DLD-1	Homo sapiens	EC50	=	160.0	nM	PMID[24953953]
NPT2410	Cell line	NCI-H1299	Homo sapiens	EC50	=	82.0	nM	PMID[19500976]
NPT404	Cell line	CCRF-CEM	Homo sapiens	Ratio IC50	=	685.0	n.a.	PMID[15711537]
NPT404	Cell line	CCRF-CEM	Homo sapiens	Ratio IC50	=	107.0	n.a.	PMID[19581457]
NPT404	Cell line	CCRF-CEM	Homo sapiens	IC50	=	500.0	nM	PMID[19581457]
NPT91	Cell line	KB	Homo sapiens	IC50	=	0.8	nM	PMID[22620987]
NPT116	Cell line	HL-60	Homo sapiens	IC50	=	1.0	nM	Open TG-GATES in vivo data: Hematology
NPT393	Cell line	HCT-116	Homo sapiens	IC50	=	1.3	nM	PMID[18440233]
NPT83	Cell line	MCF7	Homo sapiens	IC50	=	4.6	nM	PMID[16171992]
NPT148	Cell line	HCT-15	Homo sapiens	IC50	=	10.0	nM	PMID[24583605]
NPT165	Cell line	HeLa	Homo sapiens	GI50	=	60.0	nM	PMID[19496609]
NPT83	Cell line	MCF7	Homo sapiens	GI50	=	10000.0	nM	PMID[1336040]
NPT15	Cell line	Jurkat	Homo sapiens	GI50	<	10.0	nM	DrugMatrix in vitro pharmacology data
NPT111	Cell line	K562	Homo sapiens	GI50	=	300.0	nM	DOI[10.1016/S0960-894X(97)00022-X]
NPT116	Cell line	HL-60	Homo sapiens	IC50	=	1.6	nM	PMID[20041704]
NPT400	Cell line	MDA-MB-435	Homo sapiens	IC50	=	11.0	nM	PMID[25537529]
NPT400	Cell line	MDA-MB-435	Homo sapiens	IC50	=	27.5	nM	PMID[25537529]
NPT137	Cell line	L1210	Mus musculus	IC50	=	6.0	nM	PMID[22445674]
NPT393	Cell line	HCT-116	Homo sapiens	IC50	=	6.8	nM	PMID[10869208]
NPT393	Cell line	HCT-116	Homo sapiens	IC50	=	600.0	nM	PMID[15646539]
NPT404	Cell line	CCRF-CEM	Homo sapiens	IC50	=	0.7	nM	PMID[19203247]
NPT404	Cell line	CCRF-CEM	Homo sapiens	IC50	=	80.0	nM	PMID[25856683]
NPT737	Cell line	HUVEC	Homo sapiens	IC50	=	49.0	nM	PMID[11421735]
NPT393	Cell line	HCT-116	Homo sapiens	IC50	=	27.0	nM	Open TG-GATES in vivo data: Hematology
NPT83	Cell line	MCF7	Homo sapiens	IC50	=	0.79	nM	Open TG-GATES in vivo data: Hematology
NPT81	Cell line	A549	Homo sapiens	IC50	=	17.0	nM	DrugMatrix in vitro pharmacology data
NPT171	Cell line	MRC5	Homo sapiens	Activity	=	51.5	%	PMID[20192239]
NPT116	Cell line	HL-60	Homo sapiens	IC50	=	1.11	nM	PMID[20624681]
NPT393	Cell line	HCT-116	Homo sapiens	IC50	=	1.42	nM	PMID[19586051]
NPT146	Cell line	SK-OV-3	Homo sapiens	IC50	=	2.7	nM	PMID[7911157]
NPT306	Cell line	PC-3	Homo sapiens	IC50	=	5.5	nM	Open TG-GATES in vivo data: Biochemistry
NPT148	Cell line	HCT-15	Homo sapiens	IC50	=	28.5	nM	PMID[19651906]
NPT1460	Cell line	L929	Mus musculus	IC50	=	0.018	ug.mL-1	PMID[11421732]
NPT171	Cell line	MRC5	Homo sapiens	Activity	=	60.06	%	PMID[25240095]
NPT1161	Cell line	CHO	Cricetulus griseus	IC50	=	17.0	nM	PMID[18712933]
NPT111	Cell line	K562	Homo sapiens	IC50	=	0.36	nM	PubChem BioAssay data set
NPT137	Cell line	L1210	Mus musculus	IC50	=	0.16	nM	PMID[9214736]
NPT90	Cell line	DU-145	Homo sapiens	IC50	=	0.063	nM	PMID[26090896]
NPT453	Cell line	HT-1080	Homo sapiens	IC50	=	0.099	nM	PMID[14695801]
NPT82	Cell line	MDA-MB-231	Homo sapiens	IC50	=	0.12	nM	PMID[19001116]
NPT146	Cell line	SK-OV-3	Homo sapiens	IC50	=	0.039	nM	PMID[15787444]
NPT404	Cell line	CCRF-CEM	Homo sapiens	IC50	=	0.38	nM	PMID[24328302]
NPT5195	Cell line	CHO-TAX 5-6	Cricetulus griseus	IC50	=	6.9	nM	PMID[14640526]
NPT5195	Cell line	CHO-TAX 5-6	Cricetulus griseus	Ratio IC50	=	0.41	n.a.	PMID[15711537]
NPT5196	Cell line	CHO-VV 3-2	Cricetulus griseus	IC50	=	66.0	nM	PMID[20231393]
NPT5196	Cell line	CHO-VV 3-2	Cricetulus griseus	Ratio IC50	=	3.9	n.a.	PMID[15711537]
NPT2828	Cell line	CEM-VLB	Homo sapiens	Ratio IC50	=	1579.0	n.a.	DrugMatrix in vitro pharmacology data
NPT404	Cell line	CCRF-CEM	Homo sapiens	IC50	=	4.1	nM	PMID[19746919]
NPT404	Cell line	CCRF-CEM	Homo sapiens	Ratio IC50	=	56.1	n.a.	PMID[18950230]
NPT83	Cell line	MCF7	Homo sapiens	Ratio IC50	=	1.1	n.a.	PMID[19743809]
NPT83	Cell line	MCF7	Homo sapiens	Ratio IC50	>	134.0	n.a.	PMID[25337628]
NPT401	Cell line	786-0	Homo sapiens	IC50	=	4.5	nM	PMID[20593839]
NPT401	Cell line	786-0	Homo sapiens	IC50	=	0.31	nM	PMID[23002419]
NPT381	Cell line	OVCAR-8	Homo sapiens	IC50	=	3.9	nM	Open TG-GATES in vivo data: Biochemistry
NPT378	Cell line	NCI/ADR-RES	Homo sapiens	IC50	=	582.0	nM	PMID[11678655]
NPT381	Cell line	OVCAR-8	Homo sapiens	Ratio IC50	=	149.0	n.a.	PMID[21557538]
NPT404	Cell line	CCRF-CEM	Homo sapiens	Ratio IC50	=	1579.0	n.a.	PMID[25554367]
NPT165	Cell line	HeLa	Homo sapiens	Activity	=	80.0	%	PMID[18183025]
NPT381	Cell line	OVCAR-8	Homo sapiens	IC50	=	15.0	nM	DOI[10.1007/s00044-011-9628-y]
NPT404	Cell line	CCRF-CEM	Homo sapiens	Ratio IC50	=	106.0	n.a.	PMID[25763602]
NPT404	Cell line	CCRF-CEM	Homo sapiens	Ratio IC50	=	680.0	n.a.	PMID[23398362]
NPT404	Cell line	CCRF-CEM	Homo sapiens	IC50	=	9.4	nM	PMID[19489596]
NPT82	Cell line	MDA-MB-231	Homo sapiens	IC50	=	31.0	nM	PMID[19489596]
NPT380	Cell line	U-251	Homo sapiens	IC50	=	8.1	nM	PMID[11000021]
NPT171	Cell line	MRC5	Homo sapiens	IC50	=	24.0	nM	PMID[10479318]
NPT404	Cell line	CCRF-CEM	Homo sapiens	IC50	=	0.8	nM	PMID[17074796]
NPT134	Cell line	SK-BR-3	Homo sapiens	IC50	=	0.91	nM	PMID[16137881]
NPT400	Cell line	MDA-MB-435	Homo sapiens	Activity	=	49.0	%	PMID[24900585]
NPT83	Cell line	MCF7	Homo sapiens	IC50	=	1.08	ug.mL-1	PMID[18522867]
NPT83	Cell line	MCF7	Homo sapiens	IC50	=	1.37	ug.mL-1	PMID[19331413]
NPT83	Cell line	MCF7	Homo sapiens	IC50	=	0.047	ug.mL-1	PubChem BioAssay data set
NPT4599	Cell line	S9	Homo sapiens	Activity	=	6.06	%	PMID[22676269]
NPT4465	Cell line	HCT-116/VM46	Homo sapiens	IC50	=	600.0	nM	PMID[25856683]
NPT404	Cell line	CCRF-CEM	Homo sapiens	Ratio IC50	=	256.2	n.a.	PMID[22703109]
NPT83	Cell line	MCF7	Homo sapiens	Activity	=	76.24	%	PMID[19904995]
NPT65	Cell line	HepG2	Homo sapiens	Activity	=	72.13	%	PMID[1431933]
NPT83	Cell line	MCF7	Homo sapiens	Activity	=	60.35	%	PMID[18625771]
NPT65	Cell line	HepG2	Homo sapiens	Activity	=	55.0	%	PMID[19921834]
NPT83	Cell line	MCF7	Homo sapiens	Activity	=	48.75	%	PMID[20805391]
NPT65	Cell line	HepG2	Homo sapiens	Activity	=	45.13	%	PMID[25819096]
NPT83	Cell line	MCF7	Homo sapiens	Activity	=	29.6	%	PMID[20430633]
NPT65	Cell line	HepG2	Homo sapiens	Activity	=	24.25	%	PMID[20192236]
NPT65	Cell line	HepG2	Homo sapiens	Activity	=	16.13	%	PMID[19284743]
NPT83	Cell line	MCF7	Homo sapiens	Activity	=	15.18	%	PMID[18774863]
NPT65	Cell line	HepG2	Homo sapiens	Activity	=	14.38	%	PMID[21824777]
NPT83	Cell line	MCF7	Homo sapiens	Activity	=	7.82	%	PMID[24900585]
NPT83	Cell line	MCF7	Homo sapiens	IC50	=	6.1	ug.mL-1	PMID[24087924]
NPT65	Cell line	HepG2	Homo sapiens	IC50	=	4.6	ug.mL-1	PMID[22037378]
NPT492	Cell line	Caco-2	Homo sapiens	IC50	=	2.8	ug.mL-1	PubChem BioAssay data set
NPT2641	Cell line	COLO 320	Homo sapiens	IC50	=	1.6	ug.mL-1	PMID[18313307]
NPT2641	Cell line	COLO 320	Homo sapiens	IC50	=	0.52	ug.mL-1	PMID[9090867]
NPT492	Cell line	Caco-2	Homo sapiens	IC50	=	0.46	ug.mL-1	PMID[25682561]
NPT2400	Cell line	PA-1	Homo sapiens	IC50	=	0.15	ug.mL-1	PMID[18276144]
NPT2400	Cell line	PA-1	Homo sapiens	IC50	=	0.03	ug.mL-1	PMID[12932125]
NPT189	Cell line	Vero	Chlorocebus aethiops	IC50	=	27060.0	nM	PMID[20836557]
NPT83	Cell line	MCF7	Homo sapiens	IC50	=	1900.0	nM	PMID[21871694]
NPT168	Cell line	P388	Mus musculus	GI	=	84.0	%	PMID[25987378]
NPT378	Cell line	NCI/ADR-RES	Homo sapiens	IC50	=	200.0	nM	PMID[21265557]
NPT148	Cell line	HCT-15	Homo sapiens	IC50	=	24.0	nM	PMID[17503850]
NPT81	Cell line	A549	Homo sapiens	IC50	=	20.0	nM	PMID[11000028]
NPT139	Cell line	HT-29	Homo sapiens	IC50	=	30.0	nM	PMID[22194678]
NPT165	Cell line	HeLa	Homo sapiens	IC50	=	10.0	nM	PMID[25420236]
NPT400	Cell line	MDA-MB-435	Homo sapiens	IC50	=	0.4	nM	PMID[15387641]
NPT1383	Cell line	A2058	Homo sapiens	Ratio IC50	>	250.0	n.a.	PMID[23368996]
NPT4490	Cell line	IMR-90	Homo sapiens	IC50	>	1000.0	nM	PMID[24099304]
NPT1383	Cell line	A2058	Homo sapiens	IC50	=	4.0	nM	PMID[15165156]
NPT165	Cell line	HeLa	Homo sapiens	Activity	=	2.3	nM	PMID[18268091]
NPT404	Cell line	CCRF-CEM	Homo sapiens	Ratio IC50	=	105.0	n.a.	PMID[23445496]
NPT404	Cell line	CCRF-CEM	Homo sapiens	IC50	=	2.0	nM	PMID[24844534]
NPT306	Cell line	PC-3	Homo sapiens	IC50	=	5.0	nM	PMID[22435669]
NPT2268	Cell line	DOK	Homo sapiens	IC50	=	4.196	nM	Open TG-GATES in vivo data: Biochemistry
NPT1899	Cell line	DSH1	Homo sapiens	IC50	=	23.21	nM	PMID[20951582]
NPT1184	Cell line	Daoy	Homo sapiens	IC50	=	3.102	nM	PMID[23434131]
NPT90	Cell line	DU-145	Homo sapiens	IC50	=	98.66	nM	PubChem BioAssay data set
NPT1900	Cell line	DU-4475	Homo sapiens	IC50	=	383.01	nM	PMID[12392731]
NPT394	Cell line	EKVX	Homo sapiens	IC50	=	278.22	nM	PMID[24949913]
NPT1901	Cell line	EM-2	Homo sapiens	IC50	=	5.316	nM	PMID[26280920]
NPT2269	Cell line	EPLC-272H	Homo sapiens	IC50	=	10.78	nM	PMID[15711537]
NPT1905	Cell line	ES4	Homo sapiens	IC50	=	13.83	nM	PMID[21420302]
NPT1903	Cell line	ES5	Homo sapiens	IC50	=	3.882	nM	PMID[26056748]
NPT1902	Cell line	ES1	Homo sapiens	IC50	=	4.714	nM	PubChem BioAssay data set
NPT1904	Cell line	ES3	Homo sapiens	IC50	=	2.766	nM	PMID[17967913]
NPT2270	Cell line	Detroit562	Homo sapiens	IC50	=	5.531	nM	PMID[22695182]
NPT2271	Cell line	DoTc2-4510	Homo sapiens	IC50	=	16.52	nM	PMID[19874044]
NPT1908	Cell line	EC-GI-10	Homo sapiens	IC50	=	3.531	nM	PMID[24513185]
NPT3465	Cell line	ECC10	Homo sapiens	IC50	=	21.16	nM	PMID[26287401]
NPT2272	Cell line	EFM-19	Homo sapiens	IC50	=	5.242	nM	PMID[17685651]
NPT2273	Cell line	EFO-21	Homo sapiens	IC50	=	44.03	nM	Open TG-GATES in vivo data: Biochemistry
NPT2274	Cell line	EFO-27	Homo sapiens	IC50	=	7.449	nM	PubChem BioAssay data set
NPT2275	Cell line	EGI-1	Homo sapiens	IC50	=	10.81	nM	PMID[15104495]
NPT376	Cell line	A498	Homo sapiens	IC50	=	5.938	nM	PMID[25978520]
NPT81	Cell line	A549	Homo sapiens	IC50	=	4.954	nM	DrugMatrix in vitro pharmacology data
NPT2276	Cell line	A673	Homo sapiens	IC50	=	6.875	nM	PMID[23031087]
NPT1081	Cell line	BXPC-3	Homo sapiens	IC50	=	8.01	nM	PMID[17253840]
NPT2277	Cell line	C-33-A	Homo sapiens	IC50	=	12.66	nM	PMID[11908979]
NPT2278	Cell line	COLO-741	Homo sapiens	IC50	=	2.139	nM	PMID[23398362]
NPT2279	Cell line	COLO-792	Homo sapiens	IC50	=	25.63	nM	PMID[24131240]
NPT1913	Cell line	DJM-1	Homo sapiens	IC50	=	2816.86	nM	PMID[24941130]
NPT2280	Cell line	A704	Homo sapiens	IC50	=	119.71	nM	PubChem BioAssay data set
NPT2281	Cell line	ABC-1	Homo sapiens	IC50	=	15.49	nM	PMID[24592914]
NPT1911	Cell line	C2BBe1	Homo sapiens	IC50	=	16.88	nM	PMID[1336040]
NPT2282	Cell line	C32	Homo sapiens	IC50	=	866.85	nM	PMID[12608857]
NPT1912	Cell line	COLO-800	Homo sapiens	IC50	=	3.342	nM	PMID[26026364]
NPT1914	Cell line	COLO-824	Homo sapiens	IC50	=	136.2	nM	PubChem BioAssay data set
NPT2283	Cell line	DK-MG	Homo sapiens	IC50	=	6.646	nM	PMID[17606676]
NPT576	Cell line	DMS-114	Homo sapiens	IC50	=	20.94	nM	PMID[18298075]
NPT369	Cell line	ACHN	Homo sapiens	IC50	=	59.04	nM	PubChem BioAssay data set
NPT1916	Cell line	ACN	Homo sapiens	IC50	=	40.29	nM	PMID[17311456]
NPT2284	Cell line	C3A	Homo sapiens	IC50	=	332.14	nM	Open TG-GATES in vivo data: Organ Weight
NPT1452	Cell line	C8166	Homo sapiens	IC50	=	27.01	nM	PMID[18220356]
NPT1915	Cell line	COLO-829	Homo sapiens	IC50	=	19.17	nM	PMID[20439614]
NPT2285	Cell line	COR-L105	Homo sapiens	IC50	=	65.75	nM	PMID[23205944]
NPT1918	Cell line	DMS-79	Homo sapiens	IC50	=	534.65	nM	PMID[11975483]
NPT1919	Cell line	DOHH-2	Homo sapiens	IC50	=	1.809	nM	PMID[23046382]
NPT196	Cell line	AGS	Homo sapiens	IC50	=	12.3	nM	PMID[20155971]
NPT1920	Cell line	ALL-PO	Homo sapiens	IC50	=	5.215	nM	PMID[1379639]
NPT308	Cell line	CAKI-1	Homo sapiens	IC50	=	24.61	nM	PMID[23350733]
NPT2286	Cell line	CAL-120	Homo sapiens	IC50	=	87.26	nM	PMID[23357627]
NPT2287	Cell line	COR-L23	Homo sapiens	IC50	=	3.623	nM	DOI[10.6019/CHEMBL1201861]
NPT1922	Cell line	COR-L88	Homo sapiens	IC50	=	24.32	nM	PMID[19132934]
NPT572	Cell line	DMS-273	Homo sapiens	IC50	=	3.396	nM	PubChem BioAssay data set
NPT1924	Cell line	AM-38	Homo sapiens	IC50	=	36.92	nM	PMID[15787437]
NPT2288	Cell line	AN3-CA	Homo sapiens	IC50	=	9.765	nM	Open TG-GATES in vivo data: Biochemistry
NPT2289	Cell line	CAL-12T	Homo sapiens	IC50	=	55.97	nM	PMID[19114678]
NPT2290	Cell line	CAL-27	Homo sapiens	IC50	=	2.086	nM	PMID[17850214]
NPT2291	Cell line	CP50-MEL-B	Homo sapiens	IC50	=	13.12	nM	PMID[16180804]
NPT1926	Cell line	CP66-MEL	Homo sapiens	IC50	=	48.58	nM	PMID[1294697]
NPT1629	Cell line	CWR22R	Homo sapiens	IC50	=	9.815	nM	PMID[26151487]
NPT1928	Cell line	ATN-1	Homo sapiens	IC50	=	1.034	nM	PMID[21982497]
NPT2292	Cell line	CAL-33	Homo sapiens	IC50	=	6.184	nM	PMID[23252603]
NPT2293	Cell line	CAL-39	Homo sapiens	IC50	=	5.114	nM	PMID[2045816]
NPT1930	Cell line	CTB-1	Homo sapiens	IC50	=	1.636	nM	PMID[19778089]
NPT2294	Cell line	23132-87	Homo sapiens	IC50	=	20.64	nM	PMID[19805556]
NPT2295	Cell line	5637	Homo sapiens	IC50	=	0.951	nM	PMID[20481500]
NPT2296	Cell line	AU565	Homo sapiens	IC50	=	3.448	nM	PMID[23013356]
NPT2297	Cell line	ASPC1	Homo sapiens	IC50	=	13.21	nM	PMID[20022253]
NPT2298	Cell line	BALL-1	Homo sapiens	IC50	=	313.17	nM	PMID[10785432]
NPT2299	Cell line	CAL-51	Homo sapiens	IC50	=	16.39	nM	PMID[16643037]
NPT2300	Cell line	CAL-54	Homo sapiens	IC50	=	60.59	nM	PMID[18474575]
NPT2301	Cell line	CAL-62	Homo sapiens	IC50	=	10.1	nM	PMID[17323995]
NPT1932	Cell line	CTV-1	Homo sapiens	IC50	=	1.405	nM	DOI[10.6019/CHEMBL1201861]
NPT1933	Cell line	CW-2	Homo sapiens	IC50	=	101.38	nM	PMID[24412339]
NPT2302	Cell line	639-V	Homo sapiens	IC50	=	5.605	nM	PMID[18077363]
NPT2303	Cell line	647-V	Homo sapiens	IC50	=	23.03	nM	PMID[16792425]
NPT1931	Cell line	BB30-HNC	Homo sapiens	IC50	=	8.315	nM	PMID[19711971]
NPT1934	Cell line	BB49-HNC	Homo sapiens	IC50	=	12.56	nM	PMID[12027767]
NPT2304	Cell line	CAL-72	Homo sapiens	IC50	=	647.18	nM	PMID[14987072]
NPT2305	Cell line	CAL-85-1	Homo sapiens	IC50	=	6079.95	nM	PMID[14987052]
NPT2306	Cell line	Ca-Ski	Homo sapiens	IC50	=	4.694	nM	DOI[10.6019/CHEMBL1201861]
NPT1031	Cell line	Ca9-22	Homo sapiens	IC50	=	6.391	nM	DrugMatrix in vitro pharmacology data
NPT1094	Cell line	697	Homo sapiens	IC50	=	6.225	nM	PubChem BioAssay data set
NPT2307	Cell line	769-P	Homo sapiens	IC50	=	25.55	nM	PMID[6631435]
NPT401	Cell line	786-0	Homo sapiens	IC50	=	15.58	nM	PMID[20000782]
NPT1935	Cell line	BB65-RCC	Homo sapiens	IC50	=	20.7	nM	Open TG-GATES in vivo data: Hematology
NPT2308	Cell line	CAMA-1	Homo sapiens	IC50	=	32.01	nM	PMID[14575444]
NPT2309	Cell line	CAPAN-1	Homo sapiens	IC50	=	52.3	nM	PMID[25815139]
NPT2310	Cell line	CaR-1	Homo sapiens	IC50	=	45.73	nM	PMID[11430019]
NPT2311	Cell line	Calu-3	Homo sapiens	IC50	=	551.0	nM	PMID[1602301]
NPT1939	Cell line	8-MG-BA	Homo sapiens	IC50	=	6.335	nM	PMID[24095094]
NPT2312	Cell line	8305C	Homo sapiens	IC50	=	3.67	nM	PMID[11421741]
NPT2313	Cell line	BCPAP	Homo sapiens	IC50	=	2.33	nM	PMID[26295595]
NPT1937	Cell line	CAS-1	Homo sapiens	IC50	=	93.12	nM	PMID[12193010]
NPT404	Cell line	CCRF-CEM	Homo sapiens	IC50	=	10.05	nM	PMID[8864235]
NPT1938	Cell line	Calu-6	Homo sapiens	IC50	=	149.1	nM	PMID[25420236]
NPT1313	Cell line	Capan-2	Homo sapiens	IC50	=	114.18	nM	PMID[8277313]
NPT1215	Cell line	8505C	Homo sapiens	IC50	=	3.109	nM	PMID[10924166]
NPT1941	Cell line	A101D	Homo sapiens	IC50	=	31.39	nM	PMID[15050621]
NPT1940	Cell line	BE-13	Homo sapiens	IC50	=	1.416	nM	DOI[10.6019/CHEMBL1201861]
NPT2314	Cell line	BEN	Homo sapiens	IC50	=	81.23	nM	Open TG-GATES in vivo data: Hematology
NPT2315	Cell line	BFTC-905	Homo sapiens	IC50	=	3.773	nM	PMID[12105963]
NPT2316	Cell line	CFPAC-1	Homo sapiens	IC50	=	93.2	nM	PMID[7528269]
NPT1943	Cell line	CGTH-W-1	Homo sapiens	IC50	=	5.556	nM	PMID[22560584]
NPT2317	Cell line	ChaGo-K-1	Homo sapiens	IC50	=	1.013	nM	PMID[8277312]
NPT1944	Cell line	D-247MG	Homo sapiens	IC50	=	6.979	nM	PMID[8792626]
NPT2318	Cell line	A172	Homo sapiens	IC50	=	9.616	nM	PMID[26716912]
NPT2319	Cell line	A204	Homo sapiens	IC50	=	8.765	nM	PMID[22037378]
NPT1383	Cell line	A2058	Homo sapiens	IC50	=	1.218	nM	DrugMatrix in vitro pharmacology data
NPT2320	Cell line	BFTC-909	Homo sapiens	IC50	=	7.532	nM	PMID[15646539]
NPT2321	Cell line	BHT-101	Homo sapiens	IC50	=	31.36	nM	PMID[16933872]
NPT2322	Cell line	CHL-1	Homo sapiens	IC50	=	12.0	nM	PMID[17253868]
NPT1946	Cell line	D-263MG	Homo sapiens	IC50	=	9.278	nM	PMID[19884373]
NPT179	Cell line	A2780	Homo sapiens	IC50	=	4.608	nM	PMID[25801151]
NPT2323	Cell line	BHY	Homo sapiens	IC50	=	15.33	nM	PMID[14552793]
NPT2324	Cell line	CHP-212	Homo sapiens	IC50	=	3.547	nM	PMID[25856683]
NPT1947	Cell line	D283 Med	n.a.	IC50	=	39.1	nM	PMID[22209731]
NPT1953	Cell line	D-336MG	Homo sapiens	IC50	=	7.255	nM	PMID[12932129]
NPT1954	Cell line	D-392MG	Homo sapiens	IC50	=	18.86	nM	Open TG-GATES in vivo data: Biochemistry
NPT1955	Cell line	A3-KAW	Homo sapiens	IC50	=	4.32	nM	PMID[20232859]
NPT1083	Cell line	A-375	Homo sapiens	IC50	=	23.53	nM	PMID[11000018]
NPT2325	Cell line	BPH-1	Homo sapiens	IC50	=	3.263	nM	PMID[17190448]
NPT2326	Cell line	BT-20	Homo sapiens	IC50	=	37.68	nM	PMID[17358082]
NPT1952	Cell line	COLO-320-HSR	Homo sapiens	IC50	=	203.92	nM	PMID[19113894]
NPT1956	Cell line	COLO-668	Homo sapiens	IC50	=	562.6	nM	PMID[18183025]
NPT2327	Cell line	D-423MG	Homo sapiens	IC50	=	8.639	nM	PMID[2691635]
NPT1957	Cell line	D-502MG	Homo sapiens	IC50	=	23.49	nM	PMID[26216016]
NPT1958	Cell line	A388	Homo sapiens	IC50	=	6.915	nM	PMID[3373220]
NPT1959	Cell line	A4-Fuk	Homo sapiens	IC50	=	1.867	nM	PubChem BioAssay data set
NPT845	Cell line	BT-474	Homo sapiens	IC50	=	94.15	nM	PMID[23634786]
NPT457	Cell line	BT-549	Homo sapiens	IC50	=	7.977	nM	PMID[17190444]
NPT2328	Cell line	COLO-678	Homo sapiens	IC50	=	2480.78	nM	PMID[22435669]
NPT2329	Cell line	COLO-679	Homo sapiens	IC50	=	5415.81	nM	PMID[19105653]
NPT1961	Cell line	D-542MG	Homo sapiens	IC50	=	3876.68	nM	PMID[22037378]
NPT2330	Cell line	D-566MG	Homo sapiens	IC50	=	2.043	nM	PMID[18183025]
NPT2331	Cell line	A-427	Homo sapiens	IC50	=	12.55	nM	PMID[20439614]
NPT762	Cell line	A-431	Homo sapiens	IC50	=	4975.15	nM	PMID[18809939]
NPT1960	Cell line	BV-173	Homo sapiens	IC50	=	42.27	nM	PMID[23398362]
NPT1963	Cell line	Becker	Homo sapiens	IC50	=	1.126	nM	PMID[15646539]
NPT2332	Cell line	COLO-680N	Homo sapiens	IC50	=	74.71	nM	PMID[22283451]
NPT1964	Cell line	COLO-684	Homo sapiens	IC50	=	7.666	nM	PMID[22409377]
NPT1962	Cell line	DB	Homo sapiens	IC50	=	1.687	nM	DrugMatrix in vitro pharmacology data
NPT2333	Cell line	DBTRG-05MG	Homo sapiens	IC50	=	225.99	nM	PMID[23558238]
NPT1965	Cell line	DEL	Homo sapiens	IC50	=	2.16	nM	PubChem BioAssay data set
NPT2334	Cell line	NCI-H1793	Homo sapiens	IC50	=	29.6	nM	PMID[15387649]
NPT1966	Cell line	NCI-H1838	Homo sapiens	IC50	=	191.13	nM	PMID[22705001]
NPT1967	Cell line	NCI-H526	Homo sapiens	IC50	=	5.136	nM	PMID[10924160]
NPT2335	Cell line	NCI-H596	n.a.	IC50	=	156.07	nM	PMID[19072209]
NPT2336	Cell line	OE19	Homo sapiens	IC50	=	412.2	nM	PMID[11975483]
NPT2337	Cell line	OE33	Homo sapiens	IC50	=	28.59	nM	PMID[23822611]
NPT1091	Cell line	RPMI-7951	Homo sapiens	IC50	=	1.658	nM	PMID[23772699]
NPT389	Cell line	RPMI-8226	Homo sapiens	IC50	=	2.852	nM	PMID[8691203]
NPT311	Cell line	SK-LU-1	Homo sapiens	IC50	=	18.71	nM	PMID[21145140]
NPT926	Cell line	SK-MEL-1	Homo sapiens	IC50	=	67.32	nM	DOI[10.1021/np50041a029]
NPT1312	Cell line	SW1990	Homo sapiens	IC50	=	61.39	nM	PMID[19115838]
NPT2338	Cell line	SW48	Homo sapiens	IC50	=	6.943	nM	PMID[19237652]
NPT2339	Cell line	TGBC24TKB	Homo sapiens	IC50	=	32.52	nM	PMID[19223615]
NPT1971	Cell line	GI-1	Homo sapiens	IC50	=	4.362	nM	PMID[16252910]
NPT2204	Cell line	HH	Homo sapiens	IC50	=	6.367	nM	PMID[25237727]
NPT116	Cell line	HL-60	Homo sapiens	IC50	=	4.371	nM	PMID[14640517]
NPT1973	Cell line	IST-SL1	Homo sapiens	IC50	=	1.187	nM	PubChem BioAssay data set
NPT1975	Cell line	KS-1	Homo sapiens	IC50	=	7.987	nM	PMID[20919720]
NPT2340	Cell line	KU-19-19	Homo sapiens	IC50	=	43.72	nM	PMID[19848432]
NPT1976	Cell line	LNCaP-Clone-FGC	Homo sapiens	IC50	=	8.279	nM	PMID[15780635]
NPT2209	Cell line	MFH-ino	Homo sapiens	IC50	=	588.37	nM	PMID[11520227]
NPT1978	Cell line	MFM-223	Homo sapiens	IC50	=	135.5	nM	PMID[7911157]
NPT1979	Cell line	NB13	Homo sapiens	IC50	=	3.274	nM	PMID[16038557]
NPT2341	Cell line	NCI-H1975	Homo sapiens	IC50	=	24.23	nM	PMID[24467317]
NPT2342	Cell line	NCI-H630	Homo sapiens	IC50	=	241.69	nM	Open TG-GATES in vivo data: Biochemistry
NPT2343	Cell line	NCI-H650	Homo sapiens	IC50	=	27.08	nM	PMID[20516271]
NPT1968	Cell line	OMC-1	Homo sapiens	IC50	=	144.1	nM	PubChem BioAssay data set
NPT1984	Cell line	ONS-76	Homo sapiens	IC50	=	3.742	nM	PMID[22280816]
NPT1987	Cell line	RPMI-8866	Homo sapiens	IC50	=	1.966	nM	PMID[26317881]
NPT147	Cell line	SK-MEL-2	Homo sapiens	IC50	=	53.3	nM	PubChem BioAssay data set
NPT2344	Cell line	SK-MEL-24	Homo sapiens	IC50	=	31.55	nM	PMID[15013012]
NPT323	Cell line	SW-620	Homo sapiens	IC50	=	8.836	nM	PMID[11720532]
NPT2345	Cell line	SW626	Homo sapiens	IC50	=	23.21	nM	PMID[23305920]
NPT2346	Cell line	TI-73	Homo sapiens	IC50	=	3.212	nM	PMID[20553011]
NPT384	Cell line	TK-10	Homo sapiens	IC50	=	42.4	nM	PMID[20570625]
NPT1972	Cell line	GI-ME-N	Homo sapiens	IC50	=	6.076	nM	PubChem BioAssay data set
NPT2347	Cell line	GMS-10	Homo sapiens	IC50	=	11.28	nM	DOI[10.6019/CHEMBL1201861]
NPT2348	Cell line	HLE	Homo sapiens	IC50	=	4.235	nM	PMID[16562846]
NPT2349	Cell line	HMV-2 cell line	n.a.	IC50	=	3.905	nM	PMID[20932756]
NPT2350	Cell line	HN	Homo sapiens	IC50	=	4.15	nM	PMID[18640035]
NPT1990	Cell line	J-RT3-T3-5	Homo sapiens	IC50	=	0.7882	nM	PMID[9157193]
NPT1505	Cell line	J82	Homo sapiens	IC50	=	68.47	nM	Open TG-GATES in vivo data: Organ Weight
NPT1991	Cell line	KU812 cell line	n.a.	IC50	=	16.79	nM	PMID[18591268]
NPT390	Cell line	LOX IMVI	Homo sapiens	IC50	=	6.977	nM	PMID[9917310]
NPT2351	Cell line	MG-63	Homo sapiens	IC50	=	14.16	nM	PMID[19124662]
NPT2352	Cell line	MHH-ES-1	Homo sapiens	IC50	=	5.129	nM	PMID[12880308]
NPT1980	Cell line	NB14	Homo sapiens	IC50	=	4.953	nM	PMID[19739600]
NPT1995	Cell line	NB17	Homo sapiens	IC50	=	21.77	nM	PMID[19105653]
NPT2353	Cell line	NCI-H1993	Homo sapiens	IC50	=	3395.38	nM	DrugMatrix in vitro pharmacology data
NPT2354	Cell line	NCI-H2009	Homo sapiens	IC50	=	53.45	nM	PMID[20055495]
NPT2355	Cell line	NCI-H2029	Homo sapiens	IC50	=	203.7	nM	PMID[26836364]
NPT2356	Cell line	NCI-H661	Homo sapiens	IC50	=	8.047	nM	PMID[24369840]
NPT1396	Cell line	NCI-H69	Homo sapiens	IC50	=	525.78	nM	PMID[9677271]
NPT1997	Cell line	OS-RC-2	Homo sapiens	IC50	=	69.84	nM	PubChem BioAssay data set
NPT1998	Cell line	RS4-11	Homo sapiens	IC50	=	4.508	nM	PMID[16643049]
NPT2357	Cell line	RT-112	Homo sapiens	IC50	=	2.708	nM	PMID[15780635]
NPT170	Cell line	SK-MEL-28	Homo sapiens	IC50	=	17.04	nM	PMID[24168147]
NPT2358	Cell line	SK-MEL3	Homo sapiens	IC50	=	717.01	nM	PMID[19105653]
NPT2359	Cell line	SK-MEL-30	Homo sapiens	IC50	=	415.46	nM	PMID[24725159]
NPT1988	Cell line	SW684	Homo sapiens	IC50	=	101.3	nM	PMID[541686]
NPT2360	Cell line	SW756	Homo sapiens	IC50	=	14.7	nM	PMID[12398536]
NPT2361	Cell line	SW780	Homo sapiens	IC50	=	2.329	nM	DrugMatrix in vivo data: Pathology
NPT2362	Cell line	TYK-nu	Homo sapiens	IC50	=	11.9	nM	PMID[9868148]
NPT2363	Cell line	U-118-MG	Homo sapiens	IC50	=	45.16	nM	PMID[9677265]
NPT1989	Cell line	GOTO	Homo sapiens	IC50	=	8.207	nM	PMID[23891163]
NPT2364	Cell line	GP5d	Homo sapiens	IC50	=	4.674	nM	PubChem BioAssay data set
NPT2365	Cell line	HO-1-N-1	Homo sapiens	IC50	=	1.756	nM	PMID[17249647]
NPT379	Cell line	HOP-62	Homo sapiens	IC50	=	1406.87	nM	DrugMatrix in vitro pharmacology data
NPT2001	Cell line	JAR	Homo sapiens	IC50	=	0.608	nM	PMID[9358642]
NPT2366	Cell line	JEG-3	Homo sapiens	IC50	=	12.48	nM	PMID[12398531]
NPT1992	Cell line	KURAMOCHI	Homo sapiens	IC50	=	233.07	nM	DOI[10.6019/CHEMBL1201861]
NPT2002	Cell line	KY821	Homo sapiens	IC50	=	3.69	nM	PMID[1375626]
NPT2367	Cell line	KYSE-140	Homo sapiens	IC50	=	44.94	nM	PMID[11277766]
NPT2003	Cell line	LS-1034	Homo sapiens	IC50	=	2844.0	nM	PMID[24044895]
NPT2004	Cell line	LS-123	Homo sapiens	IC50	=	53.33	nM	PMID[11908979]
NPT2005	Cell line	MHH-NB-11	Homo sapiens	IC50	=	38.85	nM	DrugMatrix in vitro pharmacology data
NPT1996	Cell line	NB5	Homo sapiens	IC50	=	15.7	nM	PMID[21459003]
NPT2007	Cell line	NB6	Homo sapiens	IC50	=	80.02	nM	PMID[9548852]
NPT2368	Cell line	NCI-H2030	Homo sapiens	IC50	=	27.72	nM	PMID[22779787]
NPT2369	Cell line	NCI-H2052	Homo sapiens	IC50	=	24.65	nM	PMID[18052324]
NPT377	Cell line	OVCAR-3	Homo sapiens	IC50	=	46.86	nM	PMID[19179074]
NPT456	Cell line	OVCAR-4	Homo sapiens	IC50	=	27.94	nM	PMID[19877653]
NPT382	Cell line	OVCAR-5	Homo sapiens	IC50	=	13.6	nM	PMID[19943620]
NPT2370	Cell line	RVH-421	Homo sapiens	IC50	=	7.249	nM	PMID[18771321]
NPT406	Cell line	RXF 393	Homo sapiens	IC50	=	1.439	nM	PMID[17220402]
NPT1506	Cell line	SK-MES-1	Homo sapiens	IC50	=	8.645	nM	PMID[19743809]
NPT2371	Cell line	SW837	Homo sapiens	IC50	=	120.44	nM	DrugMatrix in vitro pharmacology data
NPT2014	Cell line	SW872	Homo sapiens	IC50	=	255.22	nM	PMID[18227183]
NPT1045	Cell line	U2OS	Homo sapiens	IC50	=	25.72	nM	PMID[24704617]
NPT2015	Cell line	U-266	Homo sapiens	IC50	=	10.8	nM	PMID[21080647]
NPT2016	Cell line	ES6	Homo sapiens	IC50	=	115.12	nM	PMID[9871657]
NPT2017	Cell line	ES7	Homo sapiens	IC50	=	5.753	nM	PMID[10866403]
NPT2000	Cell line	GR-ST	Homo sapiens	IC50	=	7.631	nM	PMID[16033284]
NPT2018	Cell line	GT3TKB	Homo sapiens	IC50	=	1.92	nM	PMID[22537363]
NPT2372	Cell line	H-EMC-SS	Homo sapiens	IC50	=	255.94	nM	DrugMatrix in vitro pharmacology data
NPT372	Cell line	HOP-92	Homo sapiens	IC50	=	25.92	nM	PMID[8277312]
NPT307	Cell line	HOS	Homo sapiens	IC50	=	6.25	nM	PMID[22014228]
NPT2019	Cell line	JVM-2	Homo sapiens	IC50	=	5585.18	nM	PMID[18411326]
NPT2020	Cell line	JVM-3	Homo sapiens	IC50	=	1.705	nM	PMID[22197393]
NPT2373	Cell line	KYSE-150 cell line	n.a.	IC50	=	46.53	nM	PMID[26254828]
NPT2374	Cell line	KYSE-180	Homo sapiens	IC50	=	6.385	nM	PMID[12932124]
NPT2021	Cell line	LS-411N	Homo sapiens	IC50	=	66.35	nM	PMID[19581457]
NPT2006	Cell line	MHH-PREB-1	Homo sapiens	IC50	=	1.493	nM	PMID[8450319]
NPT783	Cell line	MIA PaCa-2	Homo sapiens	IC50	=	3.388	nM	PMID[15808482]
NPT2375	Cell line	MKN-1	Homo sapiens	IC50	=	10.1	nM	PMID[16005626]
NPT2008	Cell line	NB69	Homo sapiens	IC50	=	5.73	nM	PubChem BioAssay data set
NPT2023	Cell line	NB7	Homo sapiens	IC50	=	195.12	nM	PMID[17157006]
NPT2376	Cell line	NBsusSR	Homo sapiens	IC50	=	3.232	nM	PMID[11430012]
NPT2377	Cell line	NCI-H2087	Homo sapiens	IC50	=	30.53	nM	PMID[12088429]
NPT2024	Cell line	NCI-H209	Homo sapiens	IC50	=	13.15	nM	PMID[24725159]
NPT2012	Cell line	NCI-H720	Homo sapiens	IC50	=	6.88	nM	PMID[18779359]
NPT2378	Cell line	NCI-H727	Homo sapiens	IC50	=	175.7	nM	PMID[20498315]
NPT2025	Cell line	NCI-H747	Homo sapiens	IC50	=	81.18	nM	PMID[15711537]
NPT381	Cell line	OVCAR-8	Homo sapiens	IC50	=	6.554	nM	PMID[23528295]
NPT2379	Cell line	P12-Ichikawa	Homo sapiens	IC50	=	1.704	nM	PMID[19200744]
NPT2026	Cell line	Ramos-2G6-4C10	Homo sapiens	IC50	=	1.546	nM	PMID[15104487]
NPT2380	Cell line	SK-N-AS	Homo sapiens	IC50	=	8.669	nM	PMID[20346682]
NPT2027	Cell line	SK-N-DZ	Homo sapiens	IC50	=	37.37	nM	DOI[10.6019/CHEMBL1201861]
NPT2381	Cell line	SW900	Homo sapiens	IC50	=	25.41	nM	PMID[23265253]
NPT2382	Cell line	SW948	Homo sapiens	IC50	=	75.99	nM	PMID[23631483]
NPT1535	Cell line	U-87 MG	Homo sapiens	IC50	=	29.98	nM	PMID[16872148]
NPT2031	Cell line	ES8	Homo sapiens	IC50	=	3.24	nM	PMID[23999046]
NPT2383	Cell line	ESS-1	Homo sapiens	IC50	=	4.876	nM	PMID[12828469]
NPT2891	Cell line	H4	Homo sapiens	IC50	=	5.837	nM	DOI[10.6019/CHEMBL1201861]
NPT759	Cell line	H9	Homo sapiens	IC50	=	2.248	nM	DrugMatrix in vitro pharmacology data
NPT2032	Cell line	HAL-01	Homo sapiens	IC50	=	233.41	nM	PMID[9134742]
NPT2384	Cell line	HPAF-II	Homo sapiens	IC50	=	40.05	nM	PMID[25237727]
NPT924	Cell line	HSC-2	Homo sapiens	IC50	=	20.2	nM	PMID[1431942]
NPT2385	Cell line	HSC-3	Homo sapiens	IC50	=	4.389	nM	PMID[18183025]
NPT111	Cell line	K562	Homo sapiens	IC50	=	1082.28	nM	PMID[17190448]
NPT2386	Cell line	KYSE-270	Homo sapiens	IC50	=	9.632	nM	PubChem BioAssay data set
NPT2387	Cell line	KYSE-410	Homo sapiens	IC50	=	9.297	nM	PMID[18336005]
NPT2022	Cell line	LS-513	Homo sapiens	IC50	=	56.27	nM	PMID[18838581]
NPT2034	Cell line	LU-134-A	Homo sapiens	IC50	=	8.582	nM	PMID[12502328]
NPT2388	Cell line	LU-135	Homo sapiens	IC50	=	35.58	nM	PMID[26920799]
NPT1179	Cell line	MKN-28	Homo sapiens	IC50	=	2.698	nM	PMID[15646539]
NPT1097	Cell line	MKN-45	Homo sapiens	IC50	=	48.42	nM	PubChem BioAssay data set
NPT2389	Cell line	NCI-H1048	Homo sapiens	IC50	=	10.06	nM	DrugMatrix in vitro pharmacology data
NPT2036	Cell line	NCI-H1092	Homo sapiens	IC50	=	223.56	nM	DrugMatrix in vitro pharmacology data
NPT2390	Cell line	NCI-H2122	Homo sapiens	IC50	=	3.436	nM	PMID[18973387]
NPT1082	Cell line	NCI-H2126	Homo sapiens	IC50	=	25.9	nM	PMID[16792412]
NPT2391	Cell line	NCI-H810	Homo sapiens	IC50	=	68.69	nM	PubChem BioAssay data set
NPT2040	Cell line	P30-OHK	Homo sapiens	IC50	=	11.07	nM	PMID[22871217]
NPT2392	Cell line	S-117	Homo sapiens	IC50	=	5.576	nM	PMID[20035557]
NPT2393	Cell line	SAS	Homo sapiens	IC50	=	28.13	nM	PMID[12502328]
NPT2028	Cell line	SK-N-FI	Homo sapiens	IC50	=	642.78	nM	PMID[18183025]
NPT2043	Cell line	SK-NEP-1	Homo sapiens	IC50	=	1.505	nM	PMID[18573937]
NPT2029	Cell line	SW 954	Homo sapiens	IC50	=	9.662	nM	PMID[12398531]
NPT2044	Cell line	SW 962	Homo sapiens	IC50	=	19.39	nM	PMID[22168134]
NPT371	Cell line	UO-31	Homo sapiens	IC50	=	13.94	nM	PMID[26225905]
NPT380	Cell line	U-251	Homo sapiens	IC50	=	5.018	nM	PMID[17848089]
NPT2045	Cell line	ETK-1	Homo sapiens	IC50	=	5.788	nM	PMID[25734623]
NPT2047	Cell line	HC-1	Homo sapiens	IC50	=	4.211	nM	PMID[25322455]
NPT2394	Cell line	HSC-4	Homo sapiens	IC50	=	2.355	nM	PMID[20303767]
NPT2049	Cell line	HT	Homo sapiens	IC50	=	15.64	nM	PMID[19555125]
NPT2051	Cell line	K5	Homo sapiens	IC50	=	4.682	nM	PubChem BioAssay data set
NPT2395	Cell line	KYSE-450	Homo sapiens	IC50	=	9.649	nM	PMID[22276742]
NPT2396	Cell line	KYSE-510	Homo sapiens	IC50	=	5.875	nM	PMID[25304895]
NPT2397	Cell line	KYSE-520 cell line	n.a.	IC50	=	47.62	nM	PMID[18183025]
NPT2053	Cell line	LU-139	Homo sapiens	IC50	=	14.08	nM	DrugMatrix in vitro pharmacology data
NPT2398	Cell line	MKN-7	Homo sapiens	IC50	=	76.69	nM	PMID[20801664]
NPT2055	Cell line	ML-2	Homo sapiens	IC50	=	8.652	nM	PMID[23398362]
NPT2057	Cell line	NCI-H1155	Homo sapiens	IC50	=	43.74	nM	PMID[19344127]
NPT2399	Cell line	NCI-H2170	Homo sapiens	IC50	=	33.41	nM	PMID[19596882]
NPT2039	Cell line	NCI-H82	Homo sapiens	IC50	=	1642.17	nM	PMID[25646964]
NPT2400	Cell line	PA-1	Homo sapiens	IC50	=	8.092	nM	PMID[24095094]
NPT2401	Cell line	PANC-03-27	Homo sapiens	IC50	=	5.472	nM	PMID[18327911]
NPT2402	Cell line	PANC-08-13	Homo sapiens	IC50	=	61.47	nM	PMID[18183025]
NPT2042	Cell line	SBC-1	Homo sapiens	IC50	=	8.104	nM	DrugMatrix in vitro pharmacology data
NPT2403	Cell line	SBC-5	Homo sapiens	IC50	=	7.471	nM	PMID[19805556]
NPT146	Cell line	SK-OV-3	Homo sapiens	IC50	=	8155.03	nM	PMID[22921081]
NPT2063	Cell line	SK-PN-DW	Homo sapiens	IC50	=	6.138	nM	PMID[16933872]
NPT2404	Cell line	SW982	Homo sapiens	IC50	=	8.919	nM	PMID[11140723]
NPT2405	Cell line	SAOS-2	Homo sapiens	IC50	=	32.31	nM	PMID[11858989]
NPT403	Cell line	UACC-257	Homo sapiens	IC50	=	90.53	nM	PMID[20438092]
NPT398	Cell line	UACC-62	Homo sapiens	IC50	=	8.062	nM	Open TG-GATES in vivo data: Biochemistry
NPT2065	Cell line	EW-1	Homo sapiens	IC50	=	3.148	nM	PMID[20439614]
NPT2048	Cell line	HCC1187	Homo sapiens	IC50	=	2.754	nM	PMID[15730257]
NPT2406	Cell line	HCC1395	Homo sapiens	IC50	=	29.25	nM	PMID[24725159]
NPT2407	Cell line	HCC1419	Homo sapiens	IC50	=	57.16	nM	PMID[16872140]
NPT453	Cell line	HT-1080	Homo sapiens	IC50	=	4.228	nM	PMID[20733038]
NPT658	Cell line	HT1197	Homo sapiens	IC50	=	99.76	nM	PMID[19748781]
NPT2052	Cell line	KALS-1	Homo sapiens	IC50	=	7.787	nM	PMID[17438047]
NPT2067	Cell line	KARPAS-299	Homo sapiens	IC50	=	1657.4	nM	PMID[15787464]
NPT2408	Cell line	KYSE-70 cell line	n.a.	IC50	=	48.35	nM	PMID[22148349]
NPT2068	Cell line	L-363	Homo sapiens	IC50	=	5.997	nM	PMID[23218601]
NPT2069	Cell line	Lu-65	Homo sapiens	IC50	=	115.72	nM	PMID[15217297]
NPT2409	Cell line	LU-99A	Homo sapiens	IC50	=	20.83	nM	PMID[21051535]
NPT2056	Cell line	MLMA	Homo sapiens	IC50	=	4.652	nM	PMID[27177826]
NPT2071	Cell line	MMAC-SF	Homo sapiens	IC50	=	15.09	nM	DOI[10.6019/CHEMBL1201861]
NPT2410	Cell line	NCI-H1299	Homo sapiens	IC50	=	16.42	nM	PMID[24645629]
NPT2073	Cell line	NCI-H1304	Homo sapiens	IC50	=	133.77	nM	PMID[18183025]
NPT465	Cell line	NCI-N87	Homo sapiens	IC50	=	5.671	nM	PMID[18280170]
NPT788	Cell line	SNU1	Homo sapiens	IC50	=	1.622	nM	PMID[19715320]
NPT2412	Cell line	Panc1005	Homo sapiens	IC50	=	42.8	nM	PMID[20853876]
NPT2413	Cell line	PC-14	Homo sapiens	IC50	=	3.534	nM	PMID[18077363]
NPT2062	Cell line	SCC-15	Homo sapiens	IC50	=	23.15	nM	PMID[17938185]
NPT2414	Cell line	SCC-25	Homo sapiens	IC50	=	15.68	nM	PMID[22037378]
NPT2078	Cell line	SK-UT-1	Homo sapiens	IC50	=	11.75	nM	PMID[16792412]
NPT2415	Cell line	SKG-IIIa	Homo sapiens	IC50	=	17.24	nM	PMID[22694318]
NPT2245	Cell line	SiHa	Homo sapiens	IC50	=	109.77	nM	PMID[22194678]
NPT550	Cell line	T-24	Homo sapiens	IC50	=	5.104	nM	PMID[19299129]
NPT396	Cell line	T47D	Homo sapiens	IC50	=	7.711	nM	PMID[22568524]
NPT2416	Cell line	UACC-893	Homo sapiens	IC50	=	98.3	nM	PubChem BioAssay data set
NPT2417	Cell line	UMUC3	Homo sapiens	IC50	=	5.107	nM	PMID[26425784]
NPT2066	Cell line	EW-11	Homo sapiens	IC50	=	7.151	nM	Open TG-GATES in vivo data: Organ Weight
NPT2080	Cell line	EW-13	Homo sapiens	IC50	=	36.52	nM	PMID[24035341]
NPT2418	Cell line	HCC1569	Homo sapiens	IC50	=	92.26	nM	PMID[16643030]
NPT2419	Cell line	HT-1376	Homo sapiens	IC50	=	60.4	nM	DrugMatrix in vitro pharmacology data
NPT2082	Cell line	HT-144	Homo sapiens	IC50	=	3.319	nM	PMID[26372073]
NPT2084	Cell line	KARPAS-45	Homo sapiens	IC50	=	1.793	nM	PMID[10328294]
NPT2086	Cell line	L-428	Homo sapiens	IC50	=	309.15	nM	PMID[20439614]
NPT2070	Cell line	LXF-289 cell line	n.a.	IC50	=	10.29	nM	PMID[26280920]
NPT114	Cell line	LoVo	Homo sapiens	IC50	=	6.025	nM	PMID[17253840]
NPT2072	Cell line	MN-60	Homo sapiens	IC50	=	29.44	nM	PMID[11809075]
NPT3466	Cell line	MOLT-13	Homo sapiens	IC50	=	5.603	nM	PMID[19689125]
NPT2074	Cell line	NCI-H1355	Homo sapiens	IC50	=	19.54	nM	PMID[17609121]
NPT2089	Cell line	NCI-H1395	Homo sapiens	IC50	=	4.277	nM	PMID[17887662]
NPT2411	Cell line	NCI-H2228	Homo sapiens	IC50	=	41.09	nM	PMID[15730248]
NPT405	Cell line	NCI-H226	Homo sapiens	IC50	=	13.81	nM	PMID[23357308]
NPT2420	Cell line	NCI-H2291	Homo sapiens	IC50	=	232.1	nM	PMID[26555243]
NPT2091	Cell line	SNU-5	Homo sapiens	IC50	=	132.84	nM	DrugMatrix in vitro pharmacology data
NPT306	Cell line	PC-3	Homo sapiens	IC50	=	33.37	nM	PMID[19105653]
NPT2421	Cell line	PFSK-1	Homo sapiens	IC50	=	4.972	nM	PMID[23398362]
NPT2422	Cell line	SCC-4	Homo sapiens	IC50	=	2.395	nM	PMID[25136754]
NPT2423	Cell line	SCC-9	Homo sapiens	IC50	=	10.66	nM	PMID[14510607]
NPT368	Cell line	SN12C	Homo sapiens	IC50	=	16.06	nM	PMID[22342628]
NPT392	Cell line	SNB-75	Homo sapiens	IC50	=	11.25	nM	DOI[10.1007/s00044-012-0429-8]
NPT2424	Cell line	T84	Homo sapiens	IC50	=	8147.21	nM	PMID[23398362]
NPT1125	Cell line	T98G	Homo sapiens	IC50	=	11.4	nM	PMID[24601675]
NPT2425	Cell line	UMC-11	Homo sapiens	IC50	=	76.22	nM	DrugMatrix in vivo data: Hematology
NPT2096	Cell line	VA-ES-BJ	Homo sapiens	IC50	=	3.273	nM	PMID[24080105]
NPT2097	Cell line	EW-16	Homo sapiens	IC50	=	7.832	nM	PMID[2746254]
NPT2426	Cell line	HCC1806	Homo sapiens	IC50	=	0.6303	nM	DrugMatrix in vitro pharmacology data
NPT1884	Cell line	HCC1937	Homo sapiens	IC50	=	2049.18	nM	DrugMatrix in vitro pharmacology data
NPT2427	Cell line	HCC1954	Homo sapiens	IC50	=	121.72	nM	PMID[3373220]
NPT139	Cell line	HT-29	Homo sapiens	IC50	=	45.85	nM	PMID[19835393]
NPT2428	Cell line	HT-3	Homo sapiens	IC50	=	37.07	nM	PMID[19702283]
NPT2429	Cell line	HT55	Homo sapiens	IC50	=	391.6	nM	PMID[23961115]
NPT2085	Cell line	Kasumi 1	n.a.	IC50	=	8.059	nM	PMID[21712146]
NPT2099	Cell line	KE-37	Homo sapiens	IC50	=	3.993	nM	PMID[21925888]
NPT1358	Cell line	LAMA-84	Homo sapiens	IC50	=	7.015	nM	PMID[24592914]
NPT2101	Cell line	LAN-6	Homo sapiens	IC50	=	47.7	nM	PubChem BioAssay data set
NPT2430	Cell line	M059J	Homo sapiens	IC50	=	15.06	nM	PMID[17346076]
NPT387	Cell line	M14	Homo sapiens	IC50	=	3.191	nM	PubChem BioAssay data set
NPT2088	Cell line	MOLT-16	Homo sapiens	IC50	=	2.429	nM	PMID[20624681]
NPT112	Cell line	MOLT-4	Homo sapiens	IC50	=	3.847	nM	PMID[19427200]
NPT2431	Cell line	NCI-H1437	Homo sapiens	IC50	=	7.76	nM	PMID[19228000]
NPT370	Cell line	NCI-H23	Homo sapiens	IC50	=	5.706	nM	PMID[24095094]
NPT2432	Cell line	NCI-H2342	Homo sapiens	IC50	=	950.45	nM	PMID[17428028]
NPT2092	Cell line	NEC8	Homo sapiens	IC50	=	5.122	nM	PMID[19097799]
NPT2106	Cell line	NH-12	Homo sapiens	IC50	=	26.35	nM	PMID[15332848]
NPT2107	Cell line	PSN1	Homo sapiens	IC50	=	1.248	nM	PMID[24927053]
NPT2109	Cell line	SCH	Homo sapiens	IC50	=	29.72	nM	PMID[25651042]
NPT890	Cell line	SNU-387	Homo sapiens	IC50	=	11.42	nM	PMID[7264680]
NPT2433	Cell line	SNU-423	Homo sapiens	IC50	=	19.47	nM	PMID[23398362]
NPT2434	Cell line	TCC-SUP	Homo sapiens	IC50	=	23.63	nM	PMID[21146414]
NPT2435	Cell line	VM-CUB-1	Homo sapiens	IC50	=	4.281	nM	PMID[16562847]
NPT2436	Cell line	VMRC-RCZ	Homo sapiens	IC50	=	19.27	nM	PMID[19188377]
NPT1653	Cell line	WM-115	Homo sapiens	IC50	=	10.16	nM	PMID[20550123]
NPT2098	Cell line	EW-18	Homo sapiens	IC50	=	510.36	nM	PubChem BioAssay data set
NPT2437	Cell line	EW-22	Homo sapiens	IC50	=	29.35	nM	DOI[10.1016/j.cropro.2012.12.021]
NPT2113	Cell line	EW-24	Homo sapiens	IC50	=	18.01	nM	PMID[25136754]
NPT2116	Cell line	HCC2218	Homo sapiens	IC50	=	79.26	nM	PMID[17004718]
NPT2438	Cell line	HTC-C3	Homo sapiens	IC50	=	10.38	nM	PMID[25811792]
NPT2117	Cell line	HuTu80	Homo sapiens	IC50	=	12.28	nM	PMID[22316168]
NPT2100	Cell line	KG-1	n.a.	IC50	=	18.38	nM	PMID[23089527]
NPT2118	Cell line	KGN	Homo sapiens	IC50	=	33.33	nM	PMID[4851320]
NPT2120	Cell line	LB1047-RCC	Homo sapiens	IC50	=	40.27	nM	PMID[25856683]
NPT2121	Cell line	LB2241-RCC	Homo sapiens	IC50	=	10.12	nM	PMID[24592914]
NPT2439	Cell line	MC-IXC	Homo sapiens	IC50	=	2.985	nM	PubChem BioAssay data set
NPT2122	Cell line	MC116	Homo sapiens	IC50	=	7.953	nM	PMID[17311456]
NPT2123	Cell line	MPP-89	Homo sapiens	IC50	=	30.28	nM	PMID[17846127]
NPT2440	Cell line	NCI-H1563	Homo sapiens	IC50	=	21.46	nM	PMID[20439614]
NPT2441	Cell line	NCI-H2347	Homo sapiens	IC50	=	135.12	nM	PMID[20738102]
NPT2442	Cell line	NCI-H2405	Homo sapiens	IC50	=	826.38	nM	DrugMatrix in vivo data: Biochemistry
NPT2126	Cell line	NKM-1	Homo sapiens	IC50	=	1.273	nM	PMID[12350153]
NPT2127	Cell line	NMC-G1	Homo sapiens	IC50	=	8.484	nM	PMID[23350733]
NPT2108	Cell line	QIMR-WIL	Homo sapiens	IC50	=	8.95	nM	PMID[16933872]
NPT2128	Cell line	RCC10RGB	Homo sapiens	IC50	=	510.4	nM	PMID[4032421]
NPT2111	Cell line	SF-126	Homo sapiens	IC50	=	21.9	nM	PMID[19467877]
NPT395	Cell line	SF-268	Homo sapiens	IC50	=	16.19	nM	PMID[18625771]
NPT2443	Cell line	SNU-449	Homo sapiens	IC50	=	127.72	nM	PMID[25136754]
NPT2112	Cell line	TE-1	Homo sapiens	IC50	=	10.85	nM	PMID[19124664]
NPT2130	Cell line	TE-10	Homo sapiens	IC50	=	21.47	nM	PMID[19105653]
NPT2444	Cell line	YAPC	Homo sapiens	IC50	=	86.99	nM	PMID[27046397]
NPT2445	Cell line	YH-13	Homo sapiens	IC50	=	3.702	nM	PMID[26132528]
NPT2114	Cell line	EW-3	Homo sapiens	IC50	=	37.21	nM	PMID[24856067]
NPT391	Cell line	HCC 2998	Homo sapiens	IC50	=	19.83	nM	PMID[24844534]
NPT2446	Cell line	HCC38	Homo sapiens	IC50	=	58.38	nM	PMID[8176402]
NPT402	Cell line	Hs-578T	Homo sapiens	IC50	=	17.31	nM	PMID[24893224]
NPT2447	Cell line	HuCCT-1	Homo sapiens	IC50	=	17.29	nM	DOI[10.6019/CHEMBL1201861]
NPT2119	Cell line	KINGS-1	Homo sapiens	IC50	=	9.324	nM	PMID[19596885]
NPT2448	Cell line	KLE	Homo sapiens	IC50	=	309.24	nM	PMID[17253840]
NPT2134	Cell line	LB2518-MEL	Homo sapiens	IC50	=	145.03	nM	PMID[19917748]
NPT83	Cell line	MCF7	Homo sapiens	IC50	=	31.6	nM	PMID[23675610]
NPT2137	Cell line	MS-1	Homo sapiens	IC50	=	30.83	nM	PMID[15104505]
NPT2138	Cell line	MSTO-211H	Homo sapiens	IC50	=	12.22	nM	PMID[21332115]
NPT2449	Cell line	NCI-H1573	Homo sapiens	IC50	=	30.74	nM	PMID[25735399]
NPT2139	Cell line	NCI-H1581	Homo sapiens	IC50	=	4.236	nM	PMID[6481359]
NPT2450	Cell line	NCI-H2452	Homo sapiens	IC50	=	9.587	nM	PMID[10571166]
NPT2451	Cell line	NCI-H28	Homo sapiens	IC50	=	34.26	nM	PMID[25356913]
NPT2452	Cell line	NCI-H292	n.a.	IC50	=	3.03	nM	PMID[17846127]
NPT2140	Cell line	NOMO-1	Homo sapiens	IC50	=	7.859	nM	PMID[18070958]
NPT2453	Cell line	RCM-1	Homo sapiens	IC50	=	1369.69	nM	PMID[23634786]
NPT2454	Cell line	RD	Homo sapiens	IC50	=	4.172	nM	PMID[17524651]
NPT399	Cell line	SF-295	Homo sapiens	IC50	=	36.31	nM	PMID[26046820]
NPT374	Cell line	SF-539	Homo sapiens	IC50	=	1.211	nM	PMID[22686608]
NPT2455	Cell line	SNU-C2B	Homo sapiens	IC50	=	24.67	nM	PMID[12502331]
NPT2456	Cell line	TE-11	Homo sapiens	IC50	=	5.128	nM	PMID[22245048]
NPT2144	Cell line	TE-12	Homo sapiens	IC50	=	700.72	nM	PMID[22348826]
NPT2457	Cell line	YKG-1	Homo sapiens	IC50	=	5.534	nM	PMID[17027269]
NPT994	Cell line	ZR-75-30	Homo sapiens	IC50	=	402.55	nM	PMID[25314007]
NPT2132	Cell line	EOL1	Homo sapiens	IC50	=	1.261	nM	PMID[19112026]
NPT1216	Cell line	FaDu	Homo sapiens	IC50	=	20.02	nM	PMID[26122774]
NPT2458	Cell line	FTC-133	Homo sapiens	IC50	=	8.444	nM	PMID[17291040]
NPT2459	Cell line	HCC70	Homo sapiens	IC50	=	20.8	nM	DOI[10.6019/CHEMBL1201861]
NPT2460	Cell line	HCE-4	Homo sapiens	IC50	=	18.09	nM	PMID[16945528]
NPT1229	Cell line	Huh-7	Homo sapiens	IC50	=	87.74	nM	PMID[23891163]
NPT2461	Cell line	HuO-3N1	Homo sapiens	IC50	=	4.827	nM	PMID[26331334]
NPT2462	Cell line	HuO9	Homo sapiens	IC50	=	12.64	nM	PMID[9358648]
NPT2133	Cell line	KM-H2	Homo sapiens	IC50	=	5.339	nM	PMID[24576210]
NPT386	Cell line	KM12	Homo sapiens	IC50	=	14.42	nM	PMID[20524638]
NPT2135	Cell line	LB373-MEL-D	Homo sapiens	IC50	=	64.11	nM	PMID[25372480]
NPT2463	Cell line	MDA-MB-157	Homo sapiens	IC50	=	9.064	nM	PMID[22154833]
NPT2464	Cell line	MDA-MB-175-VII	Homo sapiens	IC50	=	267.63	nM	PubChem BioAssay data set
NPT82	Cell line	MDA-MB-231	Homo sapiens	IC50	=	44.59	nM	Open TG-GATES in vivo data: Biochemistry
NPT1649	Cell line	MV4-11	Homo sapiens	IC50	=	2.805	nM	PMID[9644066]
NPT2465	Cell line	NCI-H1623	Homo sapiens	IC50	=	503.24	nM	PMID[20674349]
NPT2150	Cell line	NCI-H1648	Homo sapiens	IC50	=	5.519	nM	PMID[12617583]
NPT2466	Cell line	NCI-H358	Homo sapiens	IC50	=	37.01	nM	PubChem BioAssay data set
NPT2141	Cell line	NOS-1	Homo sapiens	IC50	=	40.88	nM	PMID[23025282]
NPT2152	Cell line	NTERA-2-cl-D1	Homo sapiens	IC50	=	5.893	nM	PMID[11141104]
NPT2467	Cell line	RERF-LC-MS	Homo sapiens	IC50	=	15.15	nM	PMID[26707398]
NPT2153	Cell line	RH-1	Homo sapiens	IC50	=	3.4	nM	DrugMatrix in vitro pharmacology data
NPT2154	Cell line	SH-4	Homo sapiens	IC50	=	43.54	nM	PMID[9463110]
NPT2155	Cell line	SHP77	Homo sapiens	IC50	=	148.18	nM	PMID[18490506]
NPT2159	Cell line	TE-5	Homo sapiens	IC50	=	6.135	nM	PMID[10346970]
NPT2160	Cell line	no-10	Homo sapiens	IC50	=	270.54	nM	PMID[20387902]
NPT2468	Cell line	G-361	Homo sapiens	IC50	=	4123.67	nM	PMID[21356592]
NPT2469	Cell line	G-401	Homo sapiens	IC50	=	8.671	nM	Open TG-GATES in vivo data: Biochemistry
NPT2470	Cell line	G-402	Homo sapiens	IC50	=	17.58	nM	PMID[23252603]
NPT2162	Cell line	HCE-T	Homo sapiens	IC50	=	20.01	nM	PMID[19651906]
NPT393	Cell line	HCT-116	Homo sapiens	IC50	=	3.626	nM	DOI[10.6019/CHEMBL1201861]
NPT2471	Cell line	HuP-T3	Homo sapiens	IC50	=	17.96	nM	PMID[23806110]
NPT2472	Cell line	HuP-T4	Homo sapiens	IC50	=	43.18	nM	PMID[19299148]
NPT2163	Cell line	KMOE-2	Homo sapiens	IC50	=	20.76	nM	PMID[22197393]
NPT2148	Cell line	LB771-HNC	Homo sapiens	IC50	=	8.574	nM	PMID[25918997]
NPT2166	Cell line	LB831-BLC	Homo sapiens	IC50	=	21.23	nM	PMID[17125241]
NPT2473	Cell line	MDA-MB-361	Homo sapiens	IC50	=	1.662	nM	PMID[8759169]
NPT2474	Cell line	MDA-MB-415	Homo sapiens	IC50	=	18.55	nM	PMID[8946743]
NPT2149	Cell line	MZ1-PC	Homo sapiens	IC50	=	24.19	nM	PMID[19128055]
NPT2168	Cell line	MZ2-MEL	Homo sapiens	IC50	=	60.31	nM	PMID[12141877]
NPT1820	Cell line	NCI-H1650	Homo sapiens	IC50	=	126.77	nM	PMID[9249976]
NPT2475	Cell line	NCI-H1651	Homo sapiens	IC50	=	23.0	nM	PMID[19769341]
NPT2476	Cell line	NCI-H441	Homo sapiens	IC50	=	473.3	nM	PMID[23079524]
NPT937	Cell line	NCI-H446	Homo sapiens	IC50	=	2.122	nM	PMID[14640510]
NPT2477	Cell line	NUGC-3	Homo sapiens	IC50	=	3.455	nM	PMID[25891102]
NPT2478	Cell line	NY	Homo sapiens	IC50	=	5315.23	nM	PMID[22939698]
NPT2479	Cell line	OAW-28	Homo sapiens	IC50	=	40.72	nM	PMID[23273047]
NPT2480	Cell line	RH-18	Homo sapiens	IC50	=	1128.93	nM	PubChem BioAssay data set
NPT2170	Cell line	RKO	Homo sapiens	IC50	=	8.239	nM	PMID[14987066]
NPT2481	Cell line	SW1088	Homo sapiens	IC50	=	16.97	nM	PMID[11429990]
NPT2482	Cell line	SW 1116	Homo sapiens	IC50	=	1163.6	nM	PMID[12502308]
NPT2483	Cell line	SW13	Homo sapiens	IC50	=	5.49	nM	PMID[21050758]
NPT2173	Cell line	TE-6	Homo sapiens	IC50	=	56.47	nM	PMID[26042639]
NPT2161	Cell line	no-11	Homo sapiens	IC50	=	38.83	nM	PMID[11325227]
NPT2175	Cell line	GAK	Homo sapiens	IC50	=	219.86	nM	PMID[23252603]
NPT2484	Cell line	GAMG	Homo sapiens	IC50	=	19.38	nM	PMID[21930377]
NPT148	Cell line	HCT-15	Homo sapiens	IC50	=	78.58	nM	DrugMatrix in vivo data: Pathology
NPT2176	Cell line	HD-MY-Z	Homo sapiens	IC50	=	3.33	nM	PMID[19928832]
NPT2485	Cell line	IA-LM	Homo sapiens	IC50	=	68.58	nM	PMID[19496609]
NPT2486	Cell line	IGR-1	Homo sapiens	IC50	=	2.076	nM	Open TG-GATES in vivo data: Biochemistry
NPT458	Cell line	IGROV-1	Homo sapiens	IC50	=	215.27	nM	PMID[22551062]
NPT2165	Cell line	KNS-42	Homo sapiens	IC50	=	18.69	nM	PMID[20112995]
NPT2487	Cell line	KNS-62	Homo sapiens	IC50	=	5.802	nM	PMID[22642560]
NPT2180	Cell line	LC-2-ad	Homo sapiens	IC50	=	7.896	nM	PMID[12502308]
NPT2488	Cell line	MDA-MB-453	Homo sapiens	IC50	=	3.285	nM	PMID[10091706]
NPT1773	Cell line	ME-180	Homo sapiens	IC50	=	4.473	nM	DrugMatrix in vivo data: Pathology
NPT2169	Cell line	MZ7-mel	Homo sapiens	IC50	=	11.08	nM	PMID[21080629]
NPT2489	Cell line	MeWo	Homo sapiens	IC50	=	9.134	nM	PMID[12444683]
NPT2490	Cell line	NCI-H1666	Homo sapiens	IC50	=	20.12	nM	PMID[24611928]
NPT2491	Cell line	NCI-H1693	Homo sapiens	IC50	=	78.21	nM	PMID[17958396]
NPT397	Cell line	NCI-H460	Homo sapiens	IC50	=	46.39	nM	PMID[15217281]
NPT2184	Cell line	NCI-H510A	Homo sapiens	IC50	=	2.753	nM	PMID[17336532]
NPT2492	Cell line	OAW-42	Homo sapiens	IC50	=	233.12	nM	PMID[21889336]
NPT2493	Cell line	OC-314	Homo sapiens	IC50	=	2.225	nM	PMID[25554367]
NPT2494	Cell line	RMG-I	Homo sapiens	IC50	=	116.58	nM	PMID[22301215]
NPT3467	Cell line	SJRH30	Homo sapiens	IC50	=	59.36	nM	PMID[21332115]
NPT2188	Cell line	SJSA-1	Homo sapiens	IC50	=	12.06	nM	PMID[15921403]
NPT2495	Cell line	SW1417	Homo sapiens	IC50	=	423.54	nM	PMID[17585748]
NPT2496	Cell line	SW1463	Homo sapiens	IC50	=	69.69	nM	PMID[22704889]
NPT1577	Cell line	SW1573	Homo sapiens	IC50	=	33.25	nM	PMID[21131198]
NPT2174	Cell line	TE-8	Homo sapiens	IC50	=	6.156	nM	PMID[16872140]
NPT2189	Cell line	TE-9	Homo sapiens	IC50	=	4.27	nM	PMID[16933872]
NPT1354	Cell line	TGBC11TKB	Homo sapiens	IC50	=	15.83	nM	PMID[8544183]
NPT2190	Cell line	GB-1	Homo sapiens	IC50	=	39.85	nM	PMID[23738539]
NPT2177	Cell line	HDLM-2	Homo sapiens	IC50	=	642.79	nM	PMID[15711537]
NPT2497	Cell line	HEC-1	Homo sapiens	IC50	=	11.35	nM	Open TG-GATES in vivo data: Biochemistry
NPT2178	Cell line	KNS-81-FD	Homo sapiens	IC50	=	20.16	nM	PMID[15104484]
NPT2498	Cell line	KOSC-2	Homo sapiens	IC50	=	0.6975	nM	PMID[23215460]
NPT2499	Cell line	KP-4	Homo sapiens	IC50	=	2.369	nM	PMID[23350733]
NPT2500	Cell line	LCLC-103H cell line	n.a.	IC50	=	1.502	nM	PMID[14510593]
NPT2181	Cell line	MEG-01	Homo sapiens	IC50	=	14.74	nM	PMID[12061885]
NPT2501	Cell line	MEL-HO	Homo sapiens	IC50	=	53.86	nM	PMID[24900575]
NPT2502	Cell line	MEL-JUSO	Homo sapiens	IC50	=	17.51	nM	PMID[19422203]
NPT2503	Cell line	NCI-H1703	Homo sapiens	IC50	=	1.431	nM	PMID[17665953]
NPT2504	Cell line	NCI-H1755	Homo sapiens	IC50	=	19.36	nM	PMID[12932130]
NPT2505	Cell line	NCI-H520	n.a.	IC50	=	30.13	nM	PMID[19738026]
NPT2185	Cell line	OCI-AML2	Homo sapiens	IC50	=	138.49	nM	PMID[8984155]
NPT2199	Cell line	OCUB-M	Homo sapiens	IC50	=	7.561	nM	PMID[18157122]
NPT2506	Cell line	RO82-W-1	Homo sapiens	IC50	=	5.57	nM	PMID[16203143]
NPT2507	Cell line	RPMI-2650	Homo sapiens	IC50	=	26.61	nM	DOI[10.1007/s00044-012-0142-7]
NPT1086	Cell line	SK-HEP1	Homo sapiens	IC50	=	12.05	nM	PMID[12617583]
NPT2201	Cell line	SK-LMS-1	Homo sapiens	IC50	=	58.6	nM	PMID[26465972]
NPT2508	Cell line	SW1710	Homo sapiens	IC50	=	5.607	nM	PMID[20438092]
NPT2509	Cell line	SW1783	Homo sapiens	IC50	=	85.55	nM	PMID[20598551]
NPT2202	Cell line	TGBC1TKB	Homo sapiens	IC50	=	31.21	nM	PMID[16203143]
NPT2191	Cell line	GCIY	Homo sapiens	IC50	=	49.73	nM	PubChem BioAssay data set
NPT2510	Cell line	GCT	Homo sapiens	IC50	=	4.728	nM	PMID[8254344]
NPT2192	Cell line	HEL	Homo sapiens	IC50	=	32.84	nM	PMID[26613635]
NPT2511	Cell line	HGC-27	Homo sapiens	IC50	=	1.012	nM	DrugMatrix in vitro pharmacology data
NPT2205	Cell line	IST-MEL1	Homo sapiens	IC50	=	4.526	nM	PMID[15646539]
NPT2206	Cell line	IST-MES1	Homo sapiens	IC50	=	67.68	nM	PMID[24328302]
NPT2207	Cell line	KP-N-YN	Homo sapiens	IC50	=	46.36	nM	PMID[25856683]
NPT2208	Cell line	KP-N-YS	Homo sapiens	IC50	=	22.91	nM	PMID[18288806]
NPT2512	Cell line	LCLC-97TM1	Homo sapiens	IC50	=	5.491	nM	PMID[22037378]
NPT2513	Cell line	LK-2	Homo sapiens	IC50	=	7.503	nM	PMID[26200131]
NPT2514	Cell line	LN-405	Homo sapiens	IC50	=	12.4	nM	PMID[22409377]
NPT2515	Cell line	MFE-280	Homo sapiens	IC50	=	36.08	nM	PMID[25856683]
NPT2210	Cell line	NB10	Homo sapiens	IC50	=	7.317	nM	PMID[18178092]
NPT2211	Cell line	NB12	Homo sapiens	IC50	=	61.41	nM	PMID[14518939]
NPT2197	Cell line	NCI-H1770	Homo sapiens	IC50	=	28.46	nM	PMID[22831798]
NPT1669	Cell line	NCI-H1792	Homo sapiens	IC50	=	4.391	nM	PMID[20022253]
NPT1383	Cell line	A2058	Homo sapiens	IC50	=	3.7	nM	PMID[10576697]
NPT393	Cell line	HCT-116	Homo sapiens	IC50	=	3.5	nM	PubChem BioAssay data set
NPT737	Cell line	HUVEC	Homo sapiens	IC50	=	0.8	nM	PubChem BioAssay data set
NPT111	Cell line	K562	Homo sapiens	IC50	=	7.0	nM	PMID[17190456]
NPT83	Cell line	MCF7	Homo sapiens	IC50	=	10.9	nM	PMID[23190013]
NPT393	Cell line	HCT-116	Homo sapiens	Ratio IC50	=	90.0	n.a.	PMID[24223237]
NPT4465	Cell line	HCT-116/VM46	Homo sapiens	IC50	>	110.0	nM	PMID[20614907]
NPT2400	Cell line	PA-1	Homo sapiens	IC50	=	4.6	nM	PMID[23795939]
NPT133	Cell line	ZR-75-1	Homo sapiens	IC50	=	8.0	nM	PMID[23941108]
NPT396	Cell line	T47D	Homo sapiens	IC50	=	5.0	nM	PubChem BioAssay data set
NPT784	Cell line	MDA-MB-468	Homo sapiens	IC50	=	4.6	nM	PMID[19105653]
NPT83	Cell line	MCF7	Homo sapiens	IC50	>	110.0	nM	DOI[10.6019/CHEMBL1201861]
NPT2459	Cell line	HCC70	Homo sapiens	IC50	=	3.5	nM	PMID[412966]
NPT4609	Cell line	HCC1143	Homo sapiens	IC50	=	3.8	nM	PMID[412966]
NPT2505	Cell line	NCI-H520	n.a.	IC50	=	4.5	nM	PMID[21807523]
NPT2296	Cell line	AU565	Homo sapiens	IC50	=	4.0	nM	PMID[23387824]
NPT306	Cell line	PC-3	Homo sapiens	GI50	=	5.2	nM	PMID[24913558]
NPT381	Cell line	OVCAR-8	Homo sapiens	RatioGI50	=	500.0	n.a.	PMID[23956835]
NPT857	Cell line	LLC-PK1	Sus scrofa	GI50	=	1.5	nM	PMID[19243953]
NPT857	Cell line	LLC-PK1	Sus scrofa	GI50	=	86.8	nM	PMID[19467598]
NPT857	Cell line	LLC-PK1	Sus scrofa	RatioGI50	=	58.0	n.a.	PMID[23956835]
NPT111	Cell line	K562	Homo sapiens	IC50	=	2.7	nM	PMID[15808482]
NPT83	Cell line	MCF7	Homo sapiens	IC50	=	0.7	nM	PMID[15711537]
NPT404	Cell line	CCRF-CEM	Homo sapiens	IC50	=	2.9	nM	DOI[10.6019/CHEMBL1201861]
NPT404	Cell line	CCRF-CEM	Homo sapiens	IC50	=	870.0	nM	PMID[12617583]
NPT404	Cell line	CCRF-CEM	Homo sapiens	Ratio IC50	=	300.0	n.a.	PMID[19425589]
NPT333	Cell line	CEM	Homo sapiens	IC50	=	2.0	nM	PMID[18070958]
NPT83	Cell line	MCF7	Homo sapiens	IC50	=	1.02	ug.mL-1	PMID[19528279]
NPT83	Cell line	MCF7	Homo sapiens	IC50	=	1.22	ug.mL-1	PubChem BioAssay data set
NPT2454	Cell line	RD	Homo sapiens	IC50	=	52.5	nM	PMID[20100877]
NPT65	Cell line	HepG2	Homo sapiens	IC50	=	80.7	nM	PMID[20100877]
NPT400	Cell line	MDA-MB-435	Homo sapiens	Activity	=	21.0	%	PMID[22280363]
NPT139	Cell line	HT-29	Homo sapiens	Activity	=	44.0	%	PMID[22280363]
NPT404	Cell line	CCRF-CEM	Homo sapiens	IC50	=	1.3	nM	PMID[26331426]
NPT404	Cell line	CCRF-CEM	Homo sapiens	IC50	=	670.0	nM	PMID[20346682]
NPT404	Cell line	CCRF-CEM	Homo sapiens	Ratio IC50	=	248.86	n.a.	PMID[22925447]
NPT333	Cell line	CEM	Homo sapiens	IC50	=	1.0	nM	PMID[23131412]
NPT404	Cell line	CCRF-CEM	Homo sapiens	Ratio IC50	=	193.0	n.a.	PMID[25025853]
NPT333	Cell line	CEM	Homo sapiens	GI50	=	4.0	nM	DOI[10.1016/j.bmcl.2004.08.026]
NPT333	Cell line	CEM	Homo sapiens	GI50	=	210.0	nM	PMID[25600409]
NPT333	Cell line	CEM	Homo sapiens	Ratio	=	525.0	n.a.	PMID[23891163]
NPT111	Cell line	K562	Homo sapiens	IC50	=	10.0	nM	PMID[11716514]
NPT400	Cell line	MDA-MB-435	Homo sapiens	GI50	=	0.25	nM	PubChem BioAssay data set
NPT400	Cell line	MDA-MB-435	Homo sapiens	TGI	=	0.25	nM	PubChem BioAssay data set
NPT406	Cell line	RXF 393	Homo sapiens	GI50	=	1.0	nM	PubChem BioAssay data set
NPT406	Cell line	RXF 393	Homo sapiens	TGI	=	50.0	nM	PubChem BioAssay data set
NPT374	Cell line	SF-539	Homo sapiens	GI50	=	0.6	nM	PMID[23266177]
NPT374	Cell line	SF-539	Homo sapiens	TGI	=	2.5	nM	PMID[23266177]
NPT616	Cell line	MDCK	Canis lupus familiaris	Ratio	=	1.8	n.a.	DrugMatrix in vitro pharmacology data
NPT400	Cell line	MDA-MB-435	Homo sapiens	IC50	=	0.49	nM	PMID[24099364]
NPT82	Cell line	MDA-MB-231	Homo sapiens	IC50	=	8.78	nM	PMID[17954687]
NPT377	Cell line	OVCAR-3	Homo sapiens	IC50	=	1.82	nM	PMID[18280170]
NPT139	Cell line	HT-29	Homo sapiens	IC50	=	4.5	nM	PMID[24645629]
NPT400	Cell line	MDA-MB-435	Homo sapiens	IC50	=	0.5	nM	PMID[26005918]
NPT165	Cell line	HeLa	Homo sapiens	Activity	>	80.0	%	PMID[18183025]
NPT306	Cell line	PC-3	Homo sapiens	IC50	=	766.0	nM	PMID[22680914]
NPT2454	Cell line	RD	Homo sapiens	IC50	=	53.0	nM	PMID[21872367]
NPT65	Cell line	HepG2	Homo sapiens	IC50	=	81.0	nM	PMID[21872367]
NPT81	Cell line	A549	Homo sapiens	Activity	=	30.0	%	PMID[24972328]
NPT984	Cell line	Hepatocyte	n.a.	TC50	=	5.45	10'4nM	PMID[19739600]
NPT6	Organism	Plasmodium falciparum	Plasmodium falciparum	IC50	=	2.0	nM	PMID[19534474]
NPT6	Organism	Plasmodium falciparum	Plasmodium falciparum	Potency	n.a.	849.2	nM	PMID[3404160]
NPT6	Organism	Plasmodium falciparum	Plasmodium falciparum	Potency	n.a.	477.5	nM	DOI[10.1007/s00044-012-0429-8]
NPT20555	Organism	SARS-CoV-2	Severe acute respiratory syndrome coronavirus 2	Hit score	=	0.2235	n.a.	DOI[10.1101/2020.04.21.054387]
NPT20555	Organism	SARS-CoV-2	Severe acute respiratory syndrome coronavirus 2	Inhibition	=	2.15	%	DOI[10.6019/CHEMBL4495565]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	IC50	=	18.0	nM	PMID[12431060]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	IC50	=	246.0	nM	PMID[12431060]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	IC50	=	0.1	ug.mL-1	PMID[2918516]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	IC50	=	5.0	nM	PMID[8258835]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	IC50	=	540.0	nM	PMID[15324894]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	IC50	=	20.0	nM	PMID[15324894]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	IC50	=	1.6	nM	PMID[17286393]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	IC50	=	8.9	nM	PMID[17286393]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	IC50	>	375.0	nM	PMID[17567121]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	IC50	=	3.0	nM	PMID[25025991]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	IC50	=	2818.38	nM	PMID[17890094]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	IC50	=	0.11	nM	PMID[18313307]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	IC50	=	1040.0	nM	PMID[18313307]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	IC50	=	1.38	nM	PMID[18177014]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	ED50	=	0.06	ug ml-1	PMID[7853002]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	ED50	=	0.5	ug ml-1	PMID[7853002]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	ED50	=	2.6	ug ml-1	PMID[7853002]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	ED50	=	1.1	ug ml-1	PMID[7853002]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	IC50	=	90.0	nM	PMID[9868162]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	ED50	=	2.4	ug ml-1	PMID[7264682]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	Activity	=	100.0	%	PMID[8277312]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	Activity	=	0.0	%	PMID[8277312]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	IC50	=	260.0	nM	PMID[18512984]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	GI50	<	100.0	nM	PMID[19705846]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	EC50	=	12.6	nM	PMID[20597485]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	EC50	=	2037.0	nM	PMID[20597485]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	EC50	=	162.0	nM	PMID[20597485]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	EC50	=	8.5	nM	PMID[20597485]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	EC50	=	13.0	nM	PMID[20597485]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	EC50	=	28.0	nM	PMID[17417631]
NPT1188	Organism	Plasmodium yoelii yoelii	Plasmodium yoelii yoelii	IC50	=	7950.0	nM	PMID[17664328]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	IC50	=	0.4	nM	PMID[20919720]
NPT312	Organism	Saccharomyces cerevisiae	Saccharomyces cerevisiae	IZ	=	6.0	mm	PMID[17346076]
NPT312	Organism	Saccharomyces cerevisiae	Saccharomyces cerevisiae	IZ	=	0.0	mm	PMID[26034885]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	IC50	>	100.0	nM	PMID[21142180]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	IC50	=	0.63	nM	PMID[21142180]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	IC50	=	1.24	nM	PMID[21142180]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	IC50	=	2.28	nM	PMID[21324686]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	IC50	=	439.73	nM	PMID[21324686]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	Ratio IC50	=	224.18	n.a.	PMID[21324686]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	IC50	=	0.0086	ug.mL-1	PMID[21456549]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	IC50	=	1.8	nM	PMID[21604746]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	IC50	=	0.099	nM	PMID[21920638]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	IC50	=	600.0	nM	PMID[21604746]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	IC50	=	230.0	nM	PMID[22027100]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	IC50	>	375000.0	nM	PMID[21680190]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	IC50	=	200.0	nM	PMID[22044164]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	IC50	=	11.0	nM	PMID[23547728]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	IC50	=	3.5	nM	PMID[22530779]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	IC50	=	15.0	nM	PMID[22530779]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	IC50	=	4.2	nM	PMID[22530779]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	IC50	=	205.0	nM	PMID[22578111]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	Activity	=	53.42	%	DOI[10.1007/s00044-012-0142-7]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	Activity	=	47.54	%	DOI[10.1007/s00044-011-9965-x]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	Activity	=	38.06	%	DOI[10.1007/s00044-011-9965-x]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	Activity	=	28.2	%	DOI[10.1007/s00044-011-9965-x]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	Activity	=	21.68	%	DOI[10.1007/s00044-011-9965-x]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	Activity	=	16.27	%	DOI[10.1007/s00044-011-9965-x]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	IC50	=	2.6	ug.mL-1	DOI[10.1007/s00044-011-9965-x]
NPT2640	Organism	Bacopa monnieri	Bacopa monnieri	Activity	=	6.0	n.a.	PMID[20329738]
NPT2640	Organism	Bacopa monnieri	Bacopa monnieri	Activity	=	2.0	n.a.	PMID[9322367]
NPT2640	Organism	Bacopa monnieri	Bacopa monnieri	Activity	=	0.6	cm	PMID[15387639]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	IC50	=	144.0	nM	PMID[25025991]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	IC50	=	2.0	nM	PMID[25804719]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	IC50	=	9.0	nM	PMID[23368996]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	IC50	=	211.0	nM	PMID[23445496]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	IC50	=	5.2	nM	PMID[23659371]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	IC50	=	1.0	nM	PMID[24871162]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	GI50	=	5000.0	nM	PMID[23927793]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	GI50	=	6.0	nM	PMID[25671501]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	IC50	=	7.9	nM	PMID[24223237]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	IC50	=	19.6	nM	PMID[24223237]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	IC50	=	5.1	nM	PMID[24223237]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	IC50	=	2.9	nM	PMID[24223237]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	Hepatotoxicity (acute)	=	0.0	%	PMID[15646539]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	GI50	=	2.8	nM	PMID[23956835]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	GI50	=	1402.0	nM	PMID[23956835]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	IC50	=	21.0	nM	PMID[24858544]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	IC50	=	193.0	nM	PMID[25025853]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	GI50	=	1.37	nM	PMID[25768706]
NPT2588	Organism	Paracentrotus lividus	Paracentrotus lividus	EC	=	2.0	uM	DrugMatrix in vitro pharmacology data
NPT2588	Organism	Paracentrotus lividus	Paracentrotus lividus	EC	=	0.2	uM	PMID[4851320]
NPT2588	Organism	Paracentrotus lividus	Paracentrotus lividus	EC	=	0.1	uM	PMID[20346682]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	GI50	=	0.3	nM	PMID[25768706]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	TGI	=	1.6	nM	PMID[25768706]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	GI50	=	1.6	nM	PMID[25768706]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	TGI	=	320.0	nM	PMID[25768706]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	GI50	=	100.0	nM	PMID[25768706]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	TGI	=	790.0	nM	PMID[25768706]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	Hepatotoxicity (moderate)	=	5.0	n.a.	PMID[15646539]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	Hepatotoxicity (moderate)	=	22.6	%	PMID[15646539]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	Hepatotoxicity (granulomatous hepatitis)	=	0.0	n.a.	PMID[15646539]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	Hepatotoxicity (benign tumour)	=	0.0	n.a.	PMID[15646539]
NPT1018	Organism	Trypanosoma brucei	Trypanosoma brucei	IC50	=	410.0	nM	PMID[24893224]
NPT2	Others	Unspecified	n.a.	Ratio	=	19.9	n.a.	PMID[16499322]
NPT2	Others	Unspecified	n.a.	Activity	=	31.3	pM of drug (10e6*cells)-1	PMID[23398362]
NPT2	Others	Unspecified	n.a.	Activity	=	69.7	pM of drug (10e6*cells)-1	PMID[23398362]
NPT2	Others	Unspecified	n.a.	Activity	=	84.8	pM of drug (10e6*cells)-1	PMID[23398362]
NPT2	Others	Unspecified	n.a.	Activity	=	140.3	pM of drug (10e6*cells)-1	PMID[23398362]
NPT2	Others	Unspecified	n.a.	IC50	=	1000.0	nM	PMID[21958542]
NPT2	Others	Unspecified	n.a.	IC50	=	950.0	nM	PMID[16420055]
NPT2	Others	Unspecified	n.a.	IC50	=	1660.0	nM	PubChem BioAssay data set
NPT2	Others	Unspecified	n.a.	Ratio IC50	=	210.0	n.a.	PubChem BioAssay data set
NPT2	Others	Unspecified	n.a.	Activity	=	0.7	uM	DOI[10.6019/CHEMBL1201861]
NPT2	Others	Unspecified	n.a.	Activity	=	40.0	uM	PMID[18070958]
NPT2	Others	Unspecified	n.a.	Ratio IC50	=	1.0	n.a.	PMID[24927053]
NPT2	Others	Unspecified	n.a.	IC50	=	2100.0	nM	PMID[24927053]
NPT2	Others	Unspecified	n.a.	IC50	=	500.0	nM	PMID[17067155]
NPT2	Others	Unspecified	n.a.	EC50	=	8200.0	nM	PMID[20527910]
NPT2	Others	Unspecified	n.a.	IC50	=	4000.0	nM	PMID[23398362]
NPT2	Others	Unspecified	n.a.	Ratio	=	210.0	n.a.	PMID[11754588]
NPT2	Others	Unspecified	n.a.	IC50	=	2000.0	nM	PMID[19850377]
NPT2	Others	Unspecified	n.a.	IC50	=	1150.0	nM	PubChem BioAssay data set
NPT2	Others	Unspecified	n.a.	IC50	=	680.0	nM	PMID[16824761]
NPT2	Others	Unspecified	n.a.	IC50	=	17.0	nM	PMID[16824761]
NPT2	Others	Unspecified	n.a.	Ratio IC50	=	224.18	n.a.	PMID[17470393]
NPT2	Others	Unspecified	n.a.	IC50	=	25191.0	nM	PMID[23265253]
NPT2	Others	Unspecified	n.a.	Ki	=	22585.0	nM	PMID[23265253]
NPT20596	Phenotype	Hepatotoxicity	n.a.	HepSE_bilirubinemia	=	0.0	n.a.	PMID[22194678]
NPT20596	Phenotype	Hepatotoxicity	n.a.	HepSE_cholecystitis	=	0.0	n.a.	PMID[22194678]
NPT20596	Phenotype	Hepatotoxicity	n.a.	HepSE_cholelithiasis	=	0.0	n.a.	PMID[22194678]
NPT20596	Phenotype	Hepatotoxicity	n.a.	HepSE_cirrhosis	=	0.0	n.a.	PMID[22194678]
NPT20596	Phenotype	Hepatotoxicity	n.a.	HepSE_hepatic failure	=	0.0	n.a.	PMID[22194678]
NPT20596	Phenotype	Hepatotoxicity	n.a.	HepSE_hepatic necrosis	=	0.0	n.a.	PMID[22194678]
NPT20596	Phenotype	Hepatotoxicity	n.a.	HepSE_hepatomegaly	=	0.0	n.a.	PMID[22194678]
NPT20596	Phenotype	Hepatotoxicity	n.a.	HepSE_jaundice	=	0.0	n.a.	PMID[22194678]
NPT20596	Phenotype	Hepatotoxicity	n.a.	HepSE_liver fatty	=	0.0	n.a.	PMID[22194678]
NPT20596	Phenotype	Hepatotoxicity	n.a.	HepSE_liver function tests abnormal	=	0.0	n.a.	PMID[22194678]
NPT20596	Phenotype	Hepatotoxicity	n.a.	HepSE_Combined Scores	=	0.0	n.a.	PMID[22194678]
NPT2	Others	Unspecified	n.a.	Potency	n.a.	2.3	nM	PMID[22264149]
NPT2	Others	Unspecified	n.a.	Ratio IC50	=	27.5	n.a.	PMID[15911254]
NPT2	Others	Unspecified	n.a.	IC50	=	1500.0	nM	PMID[18268091]
NPT2	Others	Unspecified	n.a.	Inhibition	=	50.0	%	PMID[18161942]
NPT2	Others	Unspecified	n.a.	Ratio	=	0.5	n.a.	PMID[10377223]
NPT2	Others	Unspecified	n.a.	Inhibition	=	37.0	%	DrugMatrix in vitro pharmacology data
NPT2	Others	Unspecified	n.a.	Inhibition	=	16.0	%	PMID[23621789]
NPT2	Others	Unspecified	n.a.	Inhibition	=	53.0	%	PMID[23466226]
NPT2	Others	Unspecified	n.a.	Inhibition	=	45.0	%	PMID[23621789]
NPT471	Organism	Trypanosoma brucei brucei	Trypanosoma brucei brucei	IC50	=	94.0	nM	PMID[20855208]
NPT2	Others	Unspecified	n.a.	Activity	=	52.89	%	Open TG-GATES in vivo data: Hematology
NPT2	Others	Unspecified	n.a.	Potency	n.a.	1412.5	nM	PMID[19419802]
NPT2	Others	Unspecified	n.a.	Potency	n.a.	251.2	nM	PMID[17286393]
NPT20596	Phenotype	Hepatotoxicity	n.a.	HepSE_liver disease	=	0.0	n.a.	PMID[22194678]

In vivo activity

Target ID	Target Type	Target Name	Target Organism	Activity Type	Activity Relation	Value	Unit	Reference
NPT5516	Cell line	EBV-positive nasopharyngealcell lines	n.a.	Survival	<	0.01	n.a.	PMID[25856683]
NPT32	Organism	Mus musculus	Mus musculus	Log kill	=	2.8	n.a.	PMID[11356111]
NPT32	Organism	Mus musculus	Mus musculus	Log kill	=	1.9	n.a.	PMID[11356111]
NPT32	Organism	Mus musculus	Mus musculus	Log kill	<	0.7	n.a.	PMID[11356111]
NPT32	Organism	Mus musculus	Mus musculus	Survival days	=	11.0	n.a.	PMID[8544183]
NPT32	Organism	Mus musculus	Mus musculus	Survival days	=	15.5	n.a.	PMID[8544183]
NPT32	Organism	Mus musculus	Mus musculus	ILS	=	14.6	%	PMID[8544183]
NPT32	Organism	Mus musculus	Mus musculus	ILS	=	89.0	%	PMID[8544183]
NPT32	Organism	Mus musculus	Mus musculus	ILS	=	30.8	%	PMID[4020828]
NPT32	Organism	Mus musculus	Mus musculus	ILS	=	42.3	%	PMID[4020828]
NPT32	Organism	Mus musculus	Mus musculus	ILS	=	47.1	%	PMID[4020828]
NPT32	Organism	Mus musculus	Mus musculus	ILS	=	48.0	%	PMID[4020828]
NPT32	Organism	Mus musculus	Mus musculus	ILS	=	59.3	%	PMID[4020828]
NPT32	Organism	Mus musculus	Mus musculus	ILS	=	72.9	%	PMID[4020828]
NPT32	Organism	Mus musculus	Mus musculus	ILS	=	49.5	%	PMID[4020828]
NPT32	Organism	Mus musculus	Mus musculus	ILS	=	81.0	%	PMID[4020828]
NPT32	Organism	Mus musculus	Mus musculus	ILS	=	40.0	%	PMID[4020828]
NPT32	Organism	Mus musculus	Mus musculus	Survivors	=	0.0	n.a.	PMID[4020828]
NPT32	Organism	Mus musculus	Mus musculus	Survivors	=	1.0	n.a.	PMID[4020828]
NPT32	Organism	Mus musculus	Mus musculus	Survivors	=	4.0	n.a.	PMID[4020828]
NPT32	Organism	Mus musculus	Mus musculus	ILS	=	112.0	%	PMID[4020828]
NPT32	Organism	Mus musculus	Mus musculus	Survivors	=	5.0	n.a.	PMID[4020828]
NPT32	Organism	Mus musculus	Mus musculus	Survivors	=	2.0	n.a.	PMID[4020828]
NPT32	Organism	Mus musculus	Mus musculus	ILS	=	52.0	%	PMID[4020828]
NPT32	Organism	Mus musculus	Mus musculus	ILS	=	58.0	%	PMID[4020828]
NPT32	Organism	Mus musculus	Mus musculus	ILS	=	35.0	%	PMID[4020828]
NPT32	Organism	Mus musculus	Mus musculus	ILS	=	30.3	%	PMID[4020828]
NPT32	Organism	Mus musculus	Mus musculus	ILS	=	31.9	%	PMID[4020828]
NPT32	Organism	Mus musculus	Mus musculus	ILS	=	37.0	%	PMID[4020828]
NPT32	Organism	Mus musculus	Mus musculus	ILS	=	24.7	%	PMID[4020828]
NPT32	Organism	Mus musculus	Mus musculus	ILS	=	57.6	%	PMID[4020828]
NPT32	Organism	Mus musculus	Mus musculus	ILS	=	21.6	%	PMID[4020828]
NPT32	Organism	Mus musculus	Mus musculus	ILS	=	54.0	%	PMID[4020828]
NPT32	Organism	Mus musculus	Mus musculus	ILS	=	63.0	%	PMID[4020828]
NPT32	Organism	Mus musculus	Mus musculus	ILS	=	0.0	%	PMID[4020828]
NPT32	Organism	Mus musculus	Mus musculus	ILS	=	61.0	%	PMID[4020828]
NPT32	Organism	Mus musculus	Mus musculus	ILS	=	74.0	%	PMID[4020828]
NPT605	Organism	Homo sapiens	Homo sapiens	Fg	=	1.02	n.a.	PMID[20070106]
NPT605	Organism	Homo sapiens	Homo sapiens	F_fraction	=	0.05	n.a.	PMID[20070106]
NPT605	Organism	Homo sapiens	Homo sapiens	Fa	=	0.05	n.a.	PMID[20070106]
NPT605	Organism	Homo sapiens	Homo sapiens	Fabs	=	5.0	%	PMID[21051535]
NPT20596	Phenotype	Hepatotoxicity	n.a.	HepSE_elevated liver function tests	=	0.0	n.a.	PMID[22194678]
NPT20596	Phenotype	Hepatotoxicity	n.a.	HepSE_hepatitis	=	0.0	n.a.	PMID[22194678]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ALT	=	55.5	U.L-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ALB	=	42200.0	ug.mL-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ALP	=	406.83	U.L-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	AST	=	101.5	U.L-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	BUN	=	135.0	ug.mL-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	CO2	=	30330000.0	nM	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	CHLORIDE	=	102.17	mEq.L-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	CHOL	=	636.7	ug.mL-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	CK	=	732.67	U.L-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	CREAT	=	2.0	ug.mL-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	GLUC	=	1570.0	ug.mL-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	LDH	=	442.5	U.L-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	LIPASE	=	10.83	U.L-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	PHOS	=	126.8	ug.mL-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	POTASSIUM	=	5.67	mEq.L-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	SODIUM	=	144.0	mEq.L-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	BILI	=	1.5	ug.mL-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	PROT	=	60200.0	ug.mL-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	URATE	=	15.5	ug.mL-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	BASO	=	0.0	cells.uL-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	EOS	=	21.67	cells.uL-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	LYM	=	10193.67	cells.uL-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	MONO	=	165.83	cells.uL-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	NEUTSG	=	702.17	cells.uL-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	BASOLE	=	0.0	%	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	EOSLE	=	0.17	%	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	RBC	=	5390000.0	cells.uL-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	HCT	=	34.62	%	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	HGB	=	138000.0	ug.mL-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	WBC	=	11080.0	cells.uL-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	LYMLE	=	91.83	%	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	MCH	=	25.68	pg	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	MCHC	=	399000.0	ug.mL-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	MCV	=	64.37	fL	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	MONOLE	=	1.5	%	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	NEUTLE	=	6.5	%	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	RBCNUC	=	0.0	/100WBC	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	PLAT	=	1202830.0	cells.uL-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ALT	=	51.0	U.L-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ALB	=	41200.0	ug.mL-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ALP	=	392.67	U.L-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	AST	=	81.67	U.L-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	BUN	=	161.7	ug.mL-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	CO2	=	30670000.0	nM	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	CHLORIDE	=	100.5	mEq.L-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	CHOL	=	648.3	ug.mL-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	CK	=	242.67	U.L-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	GLUC	=	1868.3	ug.mL-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	LDH	=	188.0	U.L-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	PHOS	=	116.7	ug.mL-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	POTASSIUM	=	5.51	mEq.L-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	SODIUM	=	142.55	mEq.L-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	BILI	=	2.2	ug.mL-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	PROT	=	60800.0	ug.mL-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	URATE	=	18.5	ug.mL-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	EOS	=	17.0	cells.uL-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	LYM	=	11849.17	cells.uL-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	MONO	=	69.83	cells.uL-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	NEUTSG	=	730.67	cells.uL-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	RBC	=	5930000.0	cells.uL-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	HCT	=	37.42	%	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	HGB	=	144000.0	ug.mL-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	WBC	=	12670.0	cells.uL-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	LYMLE	=	93.17	%	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	MCH	=	24.32	pg	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	MCHC	=	385000.0	ug.mL-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	MCV	=	63.08	fL	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	MONOLE	=	0.5	%	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	NEUTLE	=	6.17	%	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	PLAT	=	1170500.0	cells.uL-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ALT	=	47.67	U.L-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ALB	=	41000.0	ug.mL-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ALP	=	395.67	U.L-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	AST	=	99.0	U.L-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	BUN	=	140.0	ug.mL-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	CO2	=	32330000.0	nM	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	CHLORIDE	=	103.33	mEq.L-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	CHOL	=	673.3	ug.mL-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	CK	=	526.33	U.L-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	CREAT	=	1.7	ug.mL-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	GLUC	=	1350.0	ug.mL-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	LDH	=	170.67	U.L-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	LIPASE	=	10.33	U.L-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	PHOS	=	119.0	ug.mL-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	POTASSIUM	=	6.35	mEq.L-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	SODIUM	=	144.8	mEq.L-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	BILI	=	1.7	ug.mL-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	PROT	=	56000.0	ug.mL-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	URATE	=	11.3	ug.mL-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	EOS	=	42.0	cells.uL-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	LYM	=	6254.33	cells.uL-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	MONO	=	40.0	cells.uL-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	NEUTSG	=	297.0	cells.uL-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	EOSLE	=	0.67	%	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	RBC	=	4480000.0	cells.uL-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	HCT	=	28.87	%	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	HGB	=	116300.0	ug.mL-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	WBC	=	6630.0	cells.uL-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	LYMLE	=	94.33	%	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	MCH	=	26.0	pg	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	MCHC	=	403300.0	ug.mL-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	MCV	=	64.43	fL	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	MONOLE	=	0.67	%	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	NEUTLE	=	4.33	%	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	PLAT	=	825330.0	cells.uL-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ALT	=	44.0	U.L-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ALB	=	39300.0	ug.mL-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ALP	=	340.67	U.L-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	AST	=	88.67	U.L-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	BUN	=	166.7	ug.mL-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	CO2	=	28000000.0	nM	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	CHLORIDE	=	101.33	mEq.L-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	CHOL	=	696.7	ug.mL-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	CK	=	599.0	U.L-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	GLUC	=	2120.0	ug.mL-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	LDH	=	334.67	U.L-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	LIPASE	=	10.67	U.L-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	PHOS	=	133.0	ug.mL-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	POTASSIUM	=	5.71	mEq.L-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	SODIUM	=	141.27	mEq.L-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	BILI	=	2.0	ug.mL-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	PROT	=	58300.0	ug.mL-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	URATE	=	17.7	ug.mL-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	EOS	=	0.0	cells.uL-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	LYM	=	7180.33	cells.uL-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	MONO	=	26.33	cells.uL-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	NEUTSG	=	293.33	cells.uL-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	EOSLE	=	0.0	%	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	RBC	=	5150000.0	cells.uL-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	HCT	=	32.43	%	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	HGB	=	130000.0	ug.mL-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	WBC	=	7500.0	cells.uL-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	LYMLE	=	95.67	%	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	MCH	=	25.27	pg	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	MCHC	=	400700.0	ug.mL-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	MCV	=	63.1	fL	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	MONOLE	=	0.33	%	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	NEUTLE	=	4.0	%	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	PLAT	=	1437000.0	cells.uL-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ALT	=	129.0	U.L-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ALB	=	40300.0	ug.mL-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ALP	=	429.0	U.L-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	AST	=	337.67	U.L-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	BUN	=	150.0	ug.mL-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	CO2	=	31000000.0	nM	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	CHLORIDE	=	102.0	mEq.L-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	CHOL	=	1040.0	ug.mL-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	CK	=	645.0	U.L-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	CREAT	=	1.6	ug.mL-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	GLUC	=	1673.3	ug.mL-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	LDH	=	246.33	U.L-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	PHOS	=	116.0	ug.mL-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	POTASSIUM	=	5.31	mEq.L-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	SODIUM	=	144.2	mEq.L-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	BILI	=	4.7	ug.mL-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	URATE	=	10.7	ug.mL-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	LYM	=	5650.33	cells.uL-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	MONO	=	34.67	cells.uL-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	NEUTSG	=	381.67	cells.uL-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	RBC	=	4960000.0	cells.uL-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	HCT	=	31.5	%	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	HGB	=	126700.0	ug.mL-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	WBC	=	6070.0	cells.uL-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	LYMLE	=	93.0	%	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	MCH	=	25.5	pg	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	MCHC	=	402300.0	ug.mL-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	MCV	=	63.4	fL	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	NEUTLE	=	6.33	%	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	PLAT	=	588330.0	cells.uL-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ALT	=	423.33	U.L-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ALB	=	36000.0	ug.mL-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ALP	=	438.67	U.L-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	AST	=	923.0	U.L-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	BUN	=	146.7	ug.mL-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	CO2	=	33000000.0	nM	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	CHLORIDE	=	96.0	mEq.L-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	CHOL	=	1923.3	ug.mL-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	CK	=	622.67	U.L-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	CREAT	=	1.0	ug.mL-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	GLUC	=	1210.0	ug.mL-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	LDH	=	415.0	U.L-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	PHOS	=	106.0	ug.mL-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	POTASSIUM	=	5.16	mEq.L-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	SODIUM	=	141.4	mEq.L-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	BILI	=	56.7	ug.mL-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	URATE	=	7.0	ug.mL-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	EOS	=	11.33	cells.uL-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	LYM	=	4520.0	cells.uL-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	MONO	=	22.67	cells.uL-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	NEUTSG	=	46.0	cells.uL-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	EOSLE	=	0.33	%	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	RBC	=	5700000.0	cells.uL-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	HCT	=	34.73	%	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	HGB	=	135000.0	ug.mL-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	WBC	=	4600.0	cells.uL-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	LYMLE	=	98.0	%	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	MCH	=	23.7	pg	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	MCHC	=	388700.0	ug.mL-1	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	MCV	=	61.03	fL	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	NEUTLE	=	1.0	%	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	RBCNUC	=	0.33	/100WBC	DOI[10.6019/CHEMBL3885881]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	PLAT	=	95670.0	cells.uL-1	DOI[10.6019/CHEMBL3885881]

Experimental ADME

Experiment Model	Experiment Tissue	ADME Type	ADME Relation	ADME Value	ADME Unit	Reference
Homo sapiens	n.a.	permeability	=	41.9	10'-6 cm/s	PMID[17606674]
Homo sapiens	n.a.	permeability	=	0.1	10'-6 cm/s	PMID[17606674]
Homo sapiens	n.a.	Papp	=	5.1	nm/s	PMID[19296600]
Homo sapiens	n.a.	Permeability	=	12.5	*10e6	PMID[10753475]
Homo sapiens	n.a.	Permeability	=	1.54	*10e6	PMID[10753475]
Homo sapiens	Plasma	Fu	=	0.14	n.a.	PMID[20070106]
Homo sapiens	n.a.	Fu	=	0.14	n.a.	PMID[18426954]

Experimental Toxicity

Quantitative toxicity

Experiment Model	Experiment Organism	Toxicity Type	Toxicity Relation	Toxicity Value	Toxicity Unit	Reference
-	Rattus norvegicus	LD50	=	2.9	mg.kg-1	PMID[24215398]
-	Mus musculus	LD50	=	10.0	mg.kg-1	PMID[19635958]
-	Mus musculus	LD50	=	27.4	mg.kg-1	PMID[25763602]
-	Mus musculus	LD50	=	28.0	mg.kg-1	PMID[22304344]
-	Mus musculus	LD50	=	26.0	mg.kg-1	PMID[14643343]

Common Abbreviations:
LC: Lethal Concentration; LD: Lethal Dose; LT:Lethal Time; NOAEL: No-observed-adverse-effect Level; BMDL: Benchmark Dose Lower Confidence Limit; BMD: Benchmark Dose; BMC:Benchmark Concentration; LOAEL: Lowest Observed Adverse Effect Level; RfD:Reference Dose; RfC:Reference Concentration; MRL: Minimal Risk Level; MEG: Maximum Exposure Guideline; PAC: Protective Action Criteria

Categorical toxicity labels

Hepatotoxicity	Carcinogenicity	Mutagenicity	Cardiotoxicity	Respiratory Toxicity	Eye Irritation	Endocrine Disruption

Note for Reference:
In addition to directly collecting NP quantitative data from primary literature (where reference will provided as NCBI PMID or DOI links), NPASS also integrated NP toxicity records from domain-specific databases. These databases include:
☉ ToxValDB: a curated database that compiles quantitative toxicity values for chemicals from diverse public sources to support toxicological research and risk assessment.
☉ TOXRIC: a comprehensive, free-to-access, online database providing toxicological/feature data. The toxicity labels are retrieved from this database. [PMID: 36400569]

Chemically structural similarity

Similar Active Natural Products in NPASS

Top-200 similar NPs were calculated against the active-NP-set (includes approximately 50,000 NPs with experimentally-derived bioactivity available in NPASS)

Similarity is measured using the Tanimoto coefficient (Tc) , which compares the binary fingerprints of two molecules. Tc is calculated as the intersection divided by the union of '1' bits in the fingerprints, ranging from 0 to 1, with 1 indicating highest similarity.

● The left chart: Distribution of similarity level between NPC195788 and all remaining natural products in the NPASS database.
● The right table: Most similar natural products (Tc>=0.5 or Top200).

range	Tanimoto Coefficient
0-0.1	21078
0.1-0.2	28123
0.2-0.3	599
0.3-0.4	48
0.4-0.5	1
0.5-0.6	1
0.6-0.7	2
0.7-0.8	5
0.8-0.85	3
0.85-0.9	0
0.9-0.95	0
0.95-1	2

Similarity Score	Similarity Level	Natural Product ID
1.0	High Similarity	NPC237901
0.9667	High Similarity	NPC485509
0.8268	Intermediate Similarity	NPC608514
0.8189	Intermediate Similarity	NPC277353
0.8189	Intermediate Similarity	NPC600057
0.7101	Intermediate Similarity	NPC260909
0.6985	Remote Similarity	NPC302688
0.6901	Remote Similarity	NPC489610
0.5918	Remote Similarity	NPC481036

Similar Clinical/Approved Drugs

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules.

● The left chart: Distribution of similarity level between NPC195788 and all drugs/candidates.
● The right table: Most similar clinical/approved drugs (Tc>=0.5 or Top200).

range	Tanimoto Coefficient
0-0.1	4407
0.1-0.2	4688
0.2-0.3	37
0.3-0.4	4
0.4-0.5	0
0.5-0.6	0
0.6-0.7	4
0.7-0.8	5
0.8-0.85	1
0.85-0.9	1
0.9-0.95	0
0.95-1	3

Similarity Score	Similarity Level	Drug ID	Developmental Stage
1.0	High Similarity	NPD8466	Phase 4
1.0	High Similarity	NPD8467	Approved
0.9667	High Similarity	NPD8465	Approved
0.8862	High Similarity	NPD8489	Phase 1
0.8125	Intermediate Similarity	NPD8364	Approved
0.7939	Intermediate Similarity	NPD8363	Approved
0.7939	Intermediate Similarity	NPD8365	Clinical (unspecified phase)
0.7101	Intermediate Similarity	NPD8460	Phase 4
0.7059	Intermediate Similarity	NPD8425	Approved
0.7059	Intermediate Similarity	NPD8426	Phase 4
0.6985	Remote Similarity	NPD8428	Approved
0.6985	Remote Similarity	NPD8429	Phase 4
0.6901	Remote Similarity	NPD8459	Approved
0.6783	Remote Similarity	NPD8427	Approved

Bioactivity similarity

Similar Natural Products in NPASS

Similarity level is defined by Bioactivity similarity was calculated based on bioactivity descriptors of compounds. The bioactivity descriptors were calculated by a recently developed AI algorithm Chemical Checker (CC) [Nature Biotechnology, 38:1087–1096, 2020; Nature Communications, 12:3932, 2021], which evaluated bioactivity similarities at five levels:
☉ A: chemistry similarity;
☉ B: biological targets similarity;
☉ C: networks similarity;
☉ D: cell-based bioactivity similarity;
☉ E: similarity based on clinical data.
Those 5 categories of CC bioactivity descriptors were calculated and then subjected to manifold projection using UMAP algorithm, to project all NPs on a 2-Dimensional space. The current NP was highlighted with a small circle in the 2-D map. Below figures: left-to-right, A-to-E.

A: chemistry similarity

B: biological targets similarity

C: networks similarity

D: cell-based bioactivity similarity

E: similarity based on clinical data