NPASS Compound

Structure

CID246693 OpenBabel06191716052D 21 22 0 0 1 0 0 0 0 0999 V2000 -4.3301 -1.5000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -3.4641 -3.0000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -2.5981 -1.5000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -2.5981 -0.5000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 2.5981 -1.5000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 2.5981 -0.5000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -0.8660 -1.5000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -3.4641 -2.0000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -0.8660 -0.5000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -1.7321 -0.0000 0.0000 C 0 0 2 0 0 0 0 0 0 0 0 0 1.7321 -2.0000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 1.7321 -0.0000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 -2.0000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 0.8660 -1.5000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 0.8660 -0.5000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 -0.0000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -1.7321 1.0000 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 1.7321 -3.0000 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 1.7321 1.0000 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 -3.0000 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 1.0000 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 1 8 1 0 0 0 0 2 8 1 0 0 0 0 3 4 1 0 0 0 0 3 8 2 0 0 0 0 4 10 1 0 0 0 0 5 6 2 0 0 0 0 5 11 1 0 0 0 0 6 12 1 0 0 0 0 7 9 2 0 0 0 0 7 13 1 0 0 0 0 9 10 1 0 0 0 0 9 16 1 0 0 0 0 10 17 1 1 0 0 0 11 14 2 0 0 0 0 11 18 1 0 0 0 0 12 15 2 0 0 0 0 12 19 1 0 0 0 0 13 14 1 0 0 0 0 13 20 2 0 0 0 0 14 15 1 0 0 0 0 15 16 1 0 0 0 0 16 21 2 0 0 0 0 M END $$$$

Physi-Chem Properties

Molecular Weight:	288.1
Volume:	293.675
LogP:	4.519
LogD:	2.936
LogS:	-3.46
# Rotatable Bonds:	3
TPSA:	97.99
# H-Bond Aceptor:	5
# H-Bond Donor:	4
# Rings:	2
# Heavy Atoms:	5

MedChem Properties

QED Drug-Likeness Score:	0.395
Synthetic Accessibility Score:	2.925
Fsp3:	0.188
Lipinski Rule-of-5:	Accepted
Pfizer Rule:	Accepted
GSK Rule:	Rejected
BMS Rule:	0
Golden Triangle Rule:	Accepted
Chelating Alert:	0
PAINS Alert:	0

ADMET Properties (ADMETlab2.0)

ADMET: Absorption

Caco-2 Permeability:	-4.909
MDCK Permeability:	8.318387699546292e-06
Pgp-inhibitor:	0.01
Pgp-substrate:	0.004
Human Intestinal Absorption (HIA):	0.021
20% Bioavailability (F20%):	0.847
30% Bioavailability (F30%):	0.99

ADMET: Distribution

Blood-Brain-Barrier Penetration (BBB):	0.005
Plasma Protein Binding (PPB):	96.12079620361328%
Volume Distribution (VD):	0.681
Pgp-substrate:	5.406493186950684%

ADMET: Metabolism

CYP1A2-inhibitor:	0.953
CYP1A2-substrate:	0.173
CYP2C19-inhibitor:	0.259
CYP2C19-substrate:	0.055
CYP2C9-inhibitor:	0.719
CYP2C9-substrate:	0.741
CYP2D6-inhibitor:	0.716
CYP2D6-substrate:	0.235
CYP3A4-inhibitor:	0.149
CYP3A4-substrate:	0.096

ADMET: Excretion

Clearance (CL):	17.16
Half-life (T1/2):	0.783

ADMET: Toxicity

hERG Blockers:	0.008
Human Hepatotoxicity (H-HT):	0.264
Drug-inuced Liver Injury (DILI):	0.805
AMES Toxicity:	0.766
Rat Oral Acute Toxicity:	0.442
Maximum Recommended Daily Dose:	0.294
Skin Sensitization:	0.922
Carcinogencity:	0.454
Eye Corrosion:	0.033
Eye Irritation:	0.942
Respiratory Toxicity:	0.401

Download Data

Data Type	Select
General Info & Identifiers & Properties
Structure MOL file
Source Organisms
Biological Activities
Similar NPs/Drugs

Natural Product: NPC246693

Natural Product ID:	NPC246693
*Common Name:**	Shikonin
IUPAC Name:	5,8-dihydroxy-2-[(1R)-1-hydroxy-4-methylpent-3-enyl]naphthalene-1,4-dione
Synonyms:
Standard InCHIKey:	NEZONWMXZKDMKF-SNVBAGLBSA-N
Standard InCHI:	InChI=1S/C16H16O5/c1-8(2)3-4-10(17)9-7-13(20)14-11(18)5-6-12(19)15(14)16(9)21/h3,5-7,10,17-19H,4H2,1-2H3/t10-/m1/s1
SMILES:	CC(=CC[C@H](C1=CC(=O)c2c(C1=O)c(O)ccc2O)O)C
Synthetic Gene Cluster:	n.a.
ChEMBL Identifier:	CHEMBL9470
PubChem CID:	479503
Chemical Classification:**	CHEMONTID:0000000 [Organic compounds] [CHEMONTID:0002448] Benzenoids [CHEMONTID:0000023] Naphthalenes [CHEMONTID:0000153] Naphthoquinones

*Note: the InCHIKey will be temporarily assigned as the "Common Name" if no IUPAC name or alternative short name is available.
**Note: the Chemical Classification was calculated by NPClassifier Version 1.5. Reference: PMID:34662515.

Species Source

Organism ID	Organism Name	Taxonomy Level	Family	SuperKingdom	Isolation Part	Collection Location	Collection Time	Reference
NPO11776	Lithospermum erythrorhizon	Species	Boraginaceae	Eukaryota	n.a.	root	n.a.	DOI[10.1007/s11418-007-0221-0]
NPO18713	Strychnos usambarensis	Species	Loganiaceae	Eukaryota	roots	n.a.	n.a.	PMID[10217724]
NPO18713	Strychnos usambarensis	Species	Loganiaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[12398531]
NPO11421	Arnebia euchroma	Species	Boraginaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[12502328]
NPO11776	Lithospermum erythrorhizon	Species	Boraginaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[17157006]
NPO26982	Callyspongia siphonella	Species	Callyspongiidae	Eukaryota	n.a.	n.a.	n.a.	PMID[17488128]
NPO11776	Lithospermum erythrorhizon	Species	Boraginaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[19217780]
NPO18713	Strychnos usambarensis	Species	Loganiaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[19299148]
NPO26982	Callyspongia siphonella	Species	Callyspongiidae	Eukaryota	n.a.	n.a.	n.a.	PMID[19534474]
NPO20181	Dracaena arborea	Species	Asparagaceae	Eukaryota	bark	Yaound, village of Bangoua, near Bangangt	2007-APR	PMID[20553003]
NPO17855	Onosma paniculata	Species	Boraginaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[22530779]
NPO5119.1	Pseudomonas chlororaphis subsp. aurantiaca	Subspecies	Pseudomonadaceae	Bacteria	n.a.	n.a.	n.a.	PMID[31999458]
NPO11776	Lithospermum erythrorhizon	Species	Boraginaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[3373224]
NPO11421	Arnebia euchroma	Species	Boraginaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[7775984]
NPO19871	Rubus arcticus	Species	Rosaceae	Eukaryota		n.a.	n.a.	Database[FooDB]
NPO20297	Arnebia guttata	Species	Boraginaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO18713	Strychnos usambarensis	Species	Loganiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO24872	Arnebia nobilis	Species	Boraginaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO16019	Isodon japonica	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO11776	Lithospermum erythrorhizon	Species	Boraginaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO11421	Arnebia euchroma	Species	Boraginaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO8642	Lithospermum officinale	Species	Boraginaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO30958	Onosma paniculatum	Species	Boraginaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO20297	Arnebia guttata	Species	Boraginaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO18713	Strychnos usambarensis	Species	Loganiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO11776	Lithospermum erythrorhizon	Species	Boraginaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO11421	Arnebia euchroma	Species	Boraginaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO24872	Arnebia nobilis	Species	Boraginaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO17855	Onosma paniculata	Species	Boraginaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO16019	Isodon japonica	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO8642	Lithospermum officinale	Species	Boraginaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO11421	Arnebia euchroma	Species	Boraginaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO11776	Lithospermum erythrorhizon	Species	Boraginaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO20297	Arnebia guttata	Species	Boraginaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO24872	Arnebia nobilis	Species	Boraginaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO30958	Onosma paniculatum	Species	Boraginaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO8642	Lithospermum officinale	Species	Boraginaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO11776	Lithospermum erythrorhizon	Species	Boraginaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TM-MC]
NPO11421	Arnebia euchroma	Species	Boraginaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TM-MC]
NPO20297	Arnebia guttata	Species	Boraginaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TM-MC]
NPO11776	Lithospermum erythrorhizon	Species	Boraginaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO8642	Lithospermum officinale	Species	Boraginaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO11300	Eucalyptus coccifera	Species	Myrtaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO11421	Arnebia euchroma	Species	Boraginaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO9209	Rhizomnium magnifolium	Species	Mniaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO18550	Teucrium gnaphalodes	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO5119.1	Pseudomonas chlororaphis subsp. aurantiaca	Subspecies	Pseudomonadaceae	Bacteria	n.a.	n.a.	n.a.	Database[UNPD]
NPO19789	Umbilicaria polyphylla	Species	Umbilicariaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO18713	Strychnos usambarensis	Species	Loganiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO17855	Onosma paniculata	Species	Boraginaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO24872	Arnebia nobilis	Species	Boraginaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO20297	Arnebia guttata	Species	Boraginaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO14913	Robinia neomexicana	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO19871	Rubus arcticus	Species	Rosaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO26982	Callyspongia siphonella	Species	Callyspongiidae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO20181	Dracaena arborea	Species	Asparagaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]

☑ Note for Reference:
In addition to directly collecting NP source organism data from primary literature (where reference will provided as NCBI PMID or DOI links), NPASS also integrated them from below databases:
☉ UNPD: Universal Natural Products Database [PMID: 23638153].
☉ StreptomeDB: a database of streptomycetes natural products [PMID: 33051671].
☉ TM-MC: a database of medicinal materials and chemical compounds in Northeast Asian traditional medicine [PMID: 26156871].
☉ TCM@Taiwan: a Traditional Chinese Medicine database [PMID: 21253603].
☉ TCMID: a Traditional Chinese Medicine database [PMID: 29106634].
☉ TCMSP: The traditional Chinese medicine systems pharmacology database and analysis platform [PMID: 24735618].
☉ HerDing: a herb recommendation system to treat diseases using genes and chemicals [PMID: 26980517].
☉ MetaboLights: a metabolomics database [PMID: 27010336].
☉ FooDB: a database of constituents, chemistry and biology of food species [www.foodb.ca].

NP Quantity Composition/Concentration

Organism ID	NP ID	Organism Material Preparation	Organism Part	NP Quantity (Standard)	NP Quantity (Minimum)	NP Quantity (Maximum)	Quantity Unit	Reference

☑ Note for Reference:
In addition to directly collecting NP quantitative data from primary literature (where reference will provided as NCBI PMID or DOI links), NPASS also integrated NP quantitative records for specific NP domains (e.g., NPS from foods or herbs) from domain-specific databases. These databases include:
☉ DUKE: Dr. Duke's Phytochemical and Ethnobotanical Databases.
☉ PHENOL EXPLORER: is the first comprehensive database on polyphenol content in foods [PMID: 24103452], its homepage can be accessed at here.
☉ FooDB: a database of constituents, chemistry and biology of food species [www.foodb.ca].

Biological Activity

Activity Type	# Activity
IC50	783
Ki	1
MIC	17
Others	90
Potency	18

Activity Type	# Activity
Cell Line	777
CELL-LINE	6
Individual Protein	42
NON-MOLECULAR	7
Organism	42
Others	25
Protein Family	6
Protein-Protein Interaction	3
Uncleic Acid	1

Target ID	Target Type	Target Name	Target Organism	Activity Type	Activity Relation	Value	Unit	Reference
NPT143	Individual Protein	DNA topoisomerase I	Homo sapiens	MIC	=	50000.0	nM	PMID[574252]
NPT143	Individual Protein	DNA topoisomerase I	Homo sapiens	IC50	=	208000.0	nM	PMID[574253]
NPT178	Individual Protein	Protein-tyrosine phosphatase 1B	Homo sapiens	IC50	=	25000.0	nM	PMID[574255]
NPT3542	Individual Protein	Protein-tyrosine phosphatase 1	Saccharomyces cerevisiae S288c	IC50	=	70000.0	nM	PMID[574255]
NPT1214	Individual Protein	Acyl coenzyme A:cholesterol acyltransferase 1	Homo sapiens	IC50	=	70400.0	nM	PMID[574256]
NPT2584	Individual Protein	Acyl coenzyme A:cholesterol acyltransferase 2	Homo sapiens	IC50	=	138200.0	nM	PMID[574256]
NPT393	Cell Line	HCT-116	Homo sapiens	IC50	=	230.0	nM	PMID[574259]
NPT65	Cell Line	HepG2	Homo sapiens	IC50	=	240.0	nM	PMID[574259]
NPT181	Cell Line	Bel-7402	Homo sapiens	IC50	=	54500.0	nM	PMID[574260]
NPT139	Cell Line	HT-29	Homo sapiens	IC50	=	16700.0	nM	PMID[574260]
NPT80	Cell Line	Raji	Homo sapiens	Activity	=	0.0	%	PMID[574261]
NPT80	Cell Line	Raji	Homo sapiens	Activity	=	10.0	%	PMID[574261]
NPT80	Cell Line	Raji	Homo sapiens	Activity	=	50.0	%	PMID[574261]
NPT80	Cell Line	Raji	Homo sapiens	Activity	>	80.0	%	PMID[574261]
NPT165	Cell Line	HeLa	Homo sapiens	IC50	=	13390.0	nM	PMID[574264]
NPT116	Cell Line	HL-60	Homo sapiens	IC50	=	440.0	nM	PMID[574264]
NPT83	Cell Line	MCF7	Homo sapiens	IC50	=	1450.0	nM	PMID[574265]
NPT116	Cell Line	HL-60	Homo sapiens	IC50	=	1030.0	nM	PMID[574265]
NPT111	Cell Line	K562	Homo sapiens	IC50	=	630.0	nM	PMID[574265]
NPT111	Cell Line	K562	Homo sapiens	Ratio IC50	=	1.06	n.a.	PMID[574265]
NPT83	Cell Line	MCF7	Homo sapiens	Ratio IC50	=	1.14	n.a.	PMID[574265]
NPT116	Cell Line	HL-60	Homo sapiens	Ratio IC50	=	1.37	n.a.	PMID[574265]
NPT47	Individual Protein	ATP-dependent DNA helicase Q1	Homo sapiens	Potency	=	10000.0	nM	PMID[574266]
NPT51	Individual Protein	Microtubule-associated protein tau	Homo sapiens	Potency	=	2238.7	nM	PMID[574266]
NPT46	Individual Protein	Thyroid hormone receptor beta-1	Homo sapiens	Potency	=	28183.8	nM	PMID[574266]
NPT51	Individual Protein	Microtubule-associated protein tau	Homo sapiens	Potency	=	4466.8	nM	PMID[574266]
NPT53	Individual Protein	4'-phosphopantetheinyl transferase ffp	Bacillus subtilis	Potency	=	50118.7	nM	PMID[574266]
NPT583	Individual Protein	Inositol monophosphatase 1	Rattus norvegicus	Potency	=	7079.5	nM	PMID[574266]
NPT442	Individual Protein	Ferritin light chain	Equus caballus	Potency	=	28183.8	nM	PMID[574266]
NPT51	Individual Protein	Microtubule-associated protein tau	Homo sapiens	Potency	=	12589.3	nM	PMID[574266]
NPT139	Cell Line	HT-29	Homo sapiens	IC50	=	15800.0	nM	PMID[574267]
NPT83	Cell Line	MCF7	Homo sapiens	IC50	=	1900.0	nM	PMID[574267]
NPT111	Cell Line	K562	Homo sapiens	IC50	=	600.0	nM	PMID[574267]
NPT1317	Cell Line	CCRF S-180	Mus musculus	Activity	=	38.9	%	PMID[574267]
NPT1317	Cell Line	CCRF S-180	Mus musculus	Activity	=	49.2	%	PMID[574267]
NPT443	Individual Protein	Histone acetyltransferase GCN5	Homo sapiens	Potency	n.a.	25118.9	nM	PMID[574266]
NPT5	Individual Protein	Histone-lysine N-methyltransferase, H3 lysine-9 specific 3	Homo sapiens	Potency	n.a.	6309.6	nM	PMID[574266]
NPT1460	Cell Line	L929	Mus musculus	IC50	=	3200.0	nM	PMID[574268]
NPT148	Cell Line	HCT-15	Homo sapiens	IC50	=	7300.0	nM	PMID[574268]
NPT3887	Cell Line	CNE	Homo sapiens	IC50	=	700.0	nM	PMID[574268]
NPT82	Cell Line	MDA-MB-231	Homo sapiens	IC50	=	6600.0	nM	PMID[574268]
NPT198	Individual Protein	Vitamin D receptor	Homo sapiens	Potency	n.a.	1778.3	nM	PMID[574266]
NPT199	Individual Protein	DNA polymerase kappa	Homo sapiens	Potency	n.a.	891.3	nM	PMID[574266]
NPT2228	Individual Protein	Neuraminidase	Influenza A virus (strain A/Brevig Mission/1/1918 H1N1) (Influenza Avirus (strain A/South Carolina/1/1918 H1N1))	IC50	=	34100.0	nM	PMID[574269]
NPT65	Cell Line	HepG2	Homo sapiens	IC50	=	28100.0	nM	PMID[574271]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	Inhibition	=	15.68	%	PMID[574272]
NPT2268	Cell Line	DOK	Homo sapiens	IC50	=	5185.18	nM	PMID[574275]
NPT1899	Cell Line	DSH1	Homo sapiens	IC50	=	10584.2	nM	PMID[574275]
NPT4600	Cell Line	DV-90	Homo sapiens	IC50	=	206842.58	nM	PMID[574275]
NPT1184	Cell Line	Daoy	Homo sapiens	IC50	=	158.77	nM	PMID[574275]
NPT90	Cell Line	DU-145	Homo sapiens	IC50	=	193.09	nM	PMID[574275]
NPT1900	Cell Line	DU-4475	Homo sapiens	IC50	=	179.84	nM	PMID[574275]
NPT4601	Cell Line	EHEB	Homo sapiens	IC50	=	2094.47	nM	PMID[574275]
NPT394	Cell Line	EKVX	Homo sapiens	IC50	=	3674.07	nM	PMID[574275]
NPT1901	Cell Line	EM-2	Homo sapiens	IC50	=	976.93	nM	PMID[574275]
NPT1902	Cell Line	ES1	Homo sapiens	IC50	=	502.89	nM	PMID[574275]
NPT1905	Cell Line	ES4	Homo sapiens	IC50	=	4634.59	nM	PMID[574275]
NPT1903	Cell Line	ES5	Homo sapiens	IC50	=	2634.45	nM	PMID[574275]
NPT1904	Cell Line	ES3	Homo sapiens	IC50	=	656.49	nM	PMID[574275]
NPT464	Cell Line	Daudi	Homo sapiens	IC50	=	3442.87	nM	PMID[574275]
NPT2270	Cell Line	Detroit562	Homo sapiens	IC50	=	29295.97	nM	PMID[574275]
NPT2271	Cell Line	DoTc2-4510	Homo sapiens	IC50	=	262.79	nM	PMID[574275]
NPT1906	Cell Line	EB-3	Homo sapiens	IC50	=	1142.2	nM	PMID[574275]
NPT1907	Cell Line	EB2	Homo sapiens	IC50	=	310.95	nM	PMID[574275]
NPT1908	Cell Line	EC-GI-10	Homo sapiens	IC50	=	57446.9	nM	PMID[574275]
NPT1909	Cell Line	ECC12	Homo sapiens	IC50	=	9648.24	nM	PMID[574275]
NPT1910	Cell Line	ECC4	Homo sapiens	IC50	=	1203.45	nM	PMID[574275]
NPT4602	Cell Line	EFE-184	Homo sapiens	IC50	=	543.94	nM	PMID[574275]
NPT2272	Cell Line	EFM-19	Homo sapiens	IC50	=	212.1	nM	PMID[574275]
NPT2273	Cell Line	EFO-21	Homo sapiens	IC50	=	1338.59	nM	PMID[574275]
NPT2274	Cell Line	EFO-27	Homo sapiens	IC50	=	330.34	nM	PMID[574275]
NPT2275	Cell Line	EGI-1	Homo sapiens	IC50	=	2511.08	nM	PMID[574275]
NPT376	Cell Line	A498	Homo sapiens	IC50	=	81.9	nM	PMID[574275]
NPT2276	Cell Line	A673	Homo sapiens	IC50	=	1220.48	nM	PMID[574275]
NPT2277	Cell Line	C-33-A	Homo sapiens	IC50	=	912.75	nM	PMID[574275]
NPT4603	Cell Line	C-4-II	Homo sapiens	IC50	=	587.72	nM	PMID[574275]
NPT2279	Cell Line	COLO-792	Homo sapiens	IC50	=	81952.6	nM	PMID[574275]
NPT1912	Cell Line	COLO-800	Homo sapiens	IC50	=	3260066.91	nM	PMID[574275]
NPT1189	Cell Line	DG-75	Homo sapiens	IC50	=	1167.49	nM	PMID[574275]
NPT1913	Cell Line	DJM-1	Homo sapiens	IC50	=	6387.23	nM	PMID[574275]
NPT2280	Cell Line	A704	Homo sapiens	IC50	=	2704.66	nM	PMID[574275]
NPT2281	Cell Line	ABC-1	Homo sapiens	IC50	=	707.48	nM	PMID[574275]
NPT1911	Cell Line	C2BBe1	Homo sapiens	IC50	=	755.64	nM	PMID[574275]
NPT2282	Cell Line	C32	Homo sapiens	IC50	=	2677.89	nM	PMID[574275]
NPT2284	Cell Line	C3A	Homo sapiens	IC50	=	657.06	nM	PMID[574275]
NPT1914	Cell Line	COLO-824	Homo sapiens	IC50	=	715.2	nM	PMID[574275]
NPT2283	Cell Line	DK-MG	Homo sapiens	IC50	=	9817.5	nM	PMID[574275]
NPT576	Cell Line	DMS-114	Homo sapiens	IC50	=	35541.18	nM	PMID[574275]
NPT369	Cell Line	ACHN	Homo sapiens	IC50	=	146.38	nM	PMID[574275]
NPT1916	Cell Line	ACN	Homo sapiens	IC50	=	916.95	nM	PMID[574275]
NPT1452	Cell Line	C8166	Homo sapiens	IC50	=	407.51	nM	PMID[574275]
NPT1915	Cell Line	COLO-829	Homo sapiens	IC50	=	657.99	nM	PMID[574275]
NPT2285	Cell Line	COR-L105	Homo sapiens	IC50	=	230.34	nM	PMID[574275]
NPT2287	Cell Line	COR-L23	Homo sapiens	IC50	=	301.5	nM	PMID[574275]
NPT1918	Cell Line	DMS-79	Homo sapiens	IC50	=	271650.96	nM	PMID[574275]
NPT1919	Cell Line	DOHH-2	Homo sapiens	IC50	=	706.26	nM	PMID[574275]
NPT196	Cell Line	AGS	Homo sapiens	IC50	=	612.57	nM	PMID[574275]
NPT1920	Cell Line	ALL-PO	Homo sapiens	IC50	=	315.12	nM	PMID[574275]
NPT1917	Cell Line	CA46	Homo sapiens	IC50	=	191.85	nM	PMID[574275]
NPT308	Cell Line	CAKI-1	Homo sapiens	IC50	=	894.13	nM	PMID[574275]
NPT2286	Cell Line	CAL-120	Homo sapiens	IC50	=	1360.85	nM	PMID[574275]
NPT1921	Cell Line	COR-L279	Homo sapiens	IC50	=	188288.43	nM	PMID[574275]
NPT1922	Cell Line	COR-L88	Homo sapiens	IC50	=	109652.36	nM	PMID[574275]
NPT1923	Cell Line	DMS-153	Homo sapiens	IC50	=	27808.34	nM	PMID[574275]
NPT572	Cell Line	DMS-273	Homo sapiens	IC50	=	395.79	nM	PMID[574275]
NPT4604	Cell Line	DMS-53	Homo sapiens	IC50	=	21456.74	nM	PMID[574275]
NPT1924	Cell Line	AM-38	Homo sapiens	IC50	=	96.31	nM	PMID[574275]
NPT2288	Cell Line	AN3-CA	Homo sapiens	IC50	=	79.65	nM	PMID[574275]
NPT2289	Cell Line	CAL-12T	Homo sapiens	IC50	=	1902.22	nM	PMID[574275]
NPT1925	Cell Line	CAL-148	Homo sapiens	IC50	=	676.6	nM	PMID[574275]
NPT2290	Cell Line	CAL-27	Homo sapiens	IC50	=	83274.14	nM	PMID[574275]
NPT2291	Cell Line	CP50-MEL-B	Homo sapiens	IC50	=	1433.36	nM	PMID[574275]
NPT1926	Cell Line	CP66-MEL	Homo sapiens	IC50	=	2396.67	nM	PMID[574275]
NPT1629	Cell Line	CWR22R	Homo sapiens	IC50	=	4614.94	nM	PMID[574275]
NPT1927	Cell Line	ARH-77	Homo sapiens	IC50	=	873.49	nM	PMID[574275]
NPT1928	Cell Line	ATN-1	Homo sapiens	IC50	=	849.13	nM	PMID[574275]
NPT2296	Cell Line	AU565	Homo sapiens	IC50	=	1239.81	nM	PMID[574275]
NPT2292	Cell Line	CAL-33	Homo sapiens	IC50	=	2000.04	nM	PMID[574275]
NPT2293	Cell Line	CAL-39	Homo sapiens	IC50	=	483.23	nM	PMID[574275]
NPT1929	Cell Line	CPC-N	Homo sapiens	IC50	=	24262.4	nM	PMID[574275]
NPT1930	Cell Line	CTB-1	Homo sapiens	IC50	=	859.02	nM	PMID[574275]
NPT2294	Cell Line	23132-87	Homo sapiens	IC50	=	2108.3	nM	PMID[574275]
NPT2295	Cell Line	5637	Homo sapiens	IC50	=	206270.21	nM	PMID[574275]
NPT2297	Cell Line	ASPC1	Homo sapiens	IC50	=	618.87	nM	PMID[574275]
NPT2299	Cell Line	CAL-51	Homo sapiens	IC50	=	20.85	nM	PMID[574275]
NPT2300	Cell Line	CAL-54	Homo sapiens	IC50	=	1419.9	nM	PMID[574275]
NPT2301	Cell Line	CAL-62	Homo sapiens	IC50	=	1279.99	nM	PMID[574275]
NPT1932	Cell Line	CTV-1	Homo sapiens	IC50	=	32752.88	nM	PMID[574275]
NPT1933	Cell Line	CW-2	Homo sapiens	IC50	=	676152.07	nM	PMID[574275]
NPT2302	Cell Line	639-V	Homo sapiens	IC50	=	265.01	nM	PMID[574275]
NPT2303	Cell Line	647-V	Homo sapiens	IC50	=	358.52	nM	PMID[574275]
NPT1094	Cell Line	697	Homo sapiens	IC50	=	875.65	nM	PMID[574275]
NPT1931	Cell Line	BB30-HNC	Homo sapiens	IC50	=	243.49	nM	PMID[574275]
NPT1934	Cell Line	BB49-HNC	Homo sapiens	IC50	=	38584.67	nM	PMID[574275]
NPT2304	Cell Line	CAL-72	Homo sapiens	IC50	=	1012.93	nM	PMID[574275]
NPT2305	Cell Line	CAL-85-1	Homo sapiens	IC50	=	160.73	nM	PMID[574275]
NPT2306	Cell Line	Ca-Ski	Homo sapiens	IC50	=	650.31	nM	PMID[574275]
NPT1031	Cell Line	Ca9-22	Homo sapiens	IC50	=	580.63	nM	PMID[574275]
NPT2307	Cell Line	769-P	Homo sapiens	IC50	=	688.6	nM	PMID[574275]
NPT401	Cell Line	786-0	Homo sapiens	IC50	=	343.75	nM	PMID[574275]
NPT1935	Cell Line	BB65-RCC	Homo sapiens	IC50	=	695.45	nM	PMID[574275]
NPT929	Cell Line	BC1 cell line		IC50	=	2681.4	nM	PMID[574275]
NPT2308	Cell Line	CAMA-1	Homo sapiens	IC50	=	1516.69	nM	PMID[574275]
NPT2309	Cell Line	CAPAN-1	Homo sapiens	IC50	=	758.89	nM	PMID[574275]
NPT2310	Cell Line	CaR-1	Homo sapiens	IC50	=	1308.43	nM	PMID[574275]
NPT1307	Cell Line	Calu-1	Homo sapiens	IC50	=	1232.12	nM	PMID[574275]
NPT2311	Cell Line	Calu-3	Homo sapiens	IC50	=	1108.34	nM	PMID[574275]
NPT1939	Cell Line	8-MG-BA	Homo sapiens	IC50	=	85.56	nM	PMID[574275]
NPT2312	Cell Line	8305C	Homo sapiens	IC50	=	304.84	nM	PMID[574275]
NPT1936	Cell Line	BC-3	Homo sapiens	IC50	=	926.19	nM	PMID[574275]
NPT2313	Cell Line	BCPAP	Homo sapiens	IC50	=	922.59	nM	PMID[574275]
NPT1940	Cell Line	BE-13	Homo sapiens	IC50	=	1195.23	nM	PMID[574275]
NPT1937	Cell Line	CAS-1	Homo sapiens	IC50	=	462.11	nM	PMID[574275]
NPT4605	Cell Line	CCF-STTG1	Homo sapiens	IC50	=	768.01	nM	PMID[574275]
NPT404	Cell Line	CCRF-CEM	Homo sapiens	IC50	=	567.02	nM	PMID[574275]
NPT1938	Cell Line	Calu-6	Homo sapiens	IC50	=	15732.0	nM	PMID[574275]
NPT4458	Cell Line	Caov-3 cell line		IC50	=	766.5	nM	PMID[574275]
NPT5419	Cell Line	Caov-4	Homo sapiens	IC50	=	1884.19	nM	PMID[574275]
NPT1313	Cell Line	Capan-2	Homo sapiens	IC50	=	1005.29	nM	PMID[574275]
NPT1215	Cell Line	8505C	Homo sapiens	IC50	=	3099.47	nM	PMID[574275]
NPT1941	Cell Line	A101D	Homo sapiens	IC50	=	0.7121	nM	PMID[574275]
NPT2314	Cell Line	BEN	Homo sapiens	IC50	=	813.72	nM	PMID[574275]
NPT2315	Cell Line	BFTC-905	Homo sapiens	IC50	=	283.61	nM	PMID[574275]
NPT1942	Cell Line	CESS	Homo sapiens	IC50	=	776.45	nM	PMID[574275]
NPT1943	Cell Line	CGTH-W-1	Homo sapiens	IC50	=	499.93	nM	PMID[574275]
NPT2317	Cell Line	ChaGo-K-1	Homo sapiens	IC50	=	656.72	nM	PMID[574275]
NPT1944	Cell Line	D-247MG	Homo sapiens	IC50	=	1660.02	nM	PMID[574275]
NPT2318	Cell Line	A172	Homo sapiens	IC50	=	469.75	nM	PMID[574275]
NPT2319	Cell Line	A204	Homo sapiens	IC50	=	126.54	nM	PMID[574275]
NPT1383	Cell Line	A2058	Homo sapiens	IC50	=	919.12	nM	PMID[574275]
NPT2320	Cell Line	BFTC-909	Homo sapiens	IC50	=	3627.83	nM	PMID[574275]
NPT2321	Cell Line	BHT-101	Homo sapiens	IC50	=	1250.23	nM	PMID[574275]
NPT2323	Cell Line	BHY	Homo sapiens	IC50	=	563.96	nM	PMID[574275]
NPT2322	Cell Line	CHL-1	Homo sapiens	IC50	=	167.8	nM	PMID[574275]
NPT1945	Cell Line	CHP-126	Homo sapiens	IC50	=	695.35	nM	PMID[574275]
NPT1946	Cell Line	D-263MG	Homo sapiens	IC50	=	2230.07	nM	PMID[574275]
NPT1947	Cell Line	D283 Med		IC50	=	835.31	nM	PMID[574275]
NPT1948	Cell Line	A253 cell line		IC50	=	7.493	nM	PMID[574275]
NPT179	Cell Line	A2780	Homo sapiens	IC50	=	2562.45	nM	PMID[574275]
NPT1949	Cell Line	BL-41	Homo sapiens	IC50	=	483.4	nM	PMID[574275]
NPT1950	Cell Line	BL-70	Homo sapiens	IC50	=	278.02	nM	PMID[574275]
NPT2324	Cell Line	CHP-212	Homo sapiens	IC50	=	1096.47	nM	PMID[574275]
NPT1951	Cell Line	CMK	Homo sapiens	IC50	=	352.13	nM	PMID[574275]
NPT407	Cell Line	COLO 205	Homo sapiens	IC50	=	537.72	nM	PMID[574275]
NPT1953	Cell Line	D-336MG	Homo sapiens	IC50	=	1749.77	nM	PMID[574275]
NPT1954	Cell Line	D-392MG	Homo sapiens	IC50	=	915.29	nM	PMID[574275]
NPT1955	Cell Line	A3-KAW	Homo sapiens	IC50	=	2140.29	nM	PMID[574275]
NPT1083	Cell Line	A-375	Homo sapiens	IC50	=	311.11	nM	PMID[574275]
NPT4606	Cell Line	BOKU	Homo sapiens	IC50	=	1874.88	nM	PMID[574275]
NPT2325	Cell Line	BPH-1	Homo sapiens	IC50	=	1259.99	nM	PMID[574275]
NPT2326	Cell Line	BT-20	Homo sapiens	IC50	=	2561.3	nM	PMID[574275]
NPT1952	Cell Line	COLO-320-HSR	Homo sapiens	IC50	=	384.48	nM	PMID[574275]
NPT1956	Cell Line	COLO-668	Homo sapiens	IC50	=	6196.13	nM	PMID[574275]
NPT1957	Cell Line	D-502MG	Homo sapiens	IC50	=	4365.48	nM	PMID[574275]
NPT1958	Cell Line	A388	Homo sapiens	IC50	=	866.56	nM	PMID[574275]
NPT1959	Cell Line	A4-Fuk	Homo sapiens	IC50	=	249.73	nM	PMID[574275]
NPT845	Cell Line	BT-474	Homo sapiens	IC50	=	208.36	nM	PMID[574275]
NPT2328	Cell Line	COLO-678	Homo sapiens	IC50	=	1628.64	nM	PMID[574275]
NPT2329	Cell Line	COLO-679	Homo sapiens	IC50	=	184.01	nM	PMID[574275]
NPT2332	Cell Line	COLO-680N	Homo sapiens	IC50	=	590.03	nM	PMID[574275]
NPT1961	Cell Line	D-542MG	Homo sapiens	IC50	=	580.88	nM	PMID[574275]
NPT1962	Cell Line	DB	Homo sapiens	IC50	=	726.29	nM	PMID[574275]
NPT2331	Cell Line	A-427	Homo sapiens	IC50	=	17.99	nM	PMID[574275]
NPT762	Cell Line	A-431	Homo sapiens	IC50	=	106.97	nM	PMID[574275]
NPT1960	Cell Line	BV-173	Homo sapiens	IC50	=	435.95	nM	PMID[574275]
NPT1963	Cell Line	Becker	Homo sapiens	IC50	=	1582.22	nM	PMID[574275]
NPT1081	Cell Line	BXPC-3	Homo sapiens	IC50	=	333.58	nM	PMID[574275]
NPT1964	Cell Line	COLO-684	Homo sapiens	IC50	=	400.53	nM	PMID[574275]
NPT2278	Cell Line	COLO-741	Homo sapiens	IC50	=	2694.21	nM	PMID[574275]
NPT2333	Cell Line	DBTRG-05MG	Homo sapiens	IC50	=	611.1	nM	PMID[574275]
NPT1965	Cell Line	DEL	Homo sapiens	IC50	=	153.81	nM	PMID[574275]
NPT1966	Cell Line	NCI-H1838	Homo sapiens	IC50	=	22434.84	nM	PMID[574275]
NPT1967	Cell Line	NCI-H526	Homo sapiens	IC50	=	2636.52	nM	PMID[574275]
NPT2335	Cell Line	NCI-H596		IC50	=	817.86	nM	PMID[574275]
NPT2337	Cell Line	OE33	Homo sapiens	IC50	=	1813.21	nM	PMID[574275]
NPT1968	Cell Line	OMC-1	Homo sapiens	IC50	=	1748.88	nM	PMID[574275]
NPT2200	Cell Line	RPMI-6666	Homo sapiens	IC50	=	587.13	nM	PMID[574275]
NPT1091	Cell Line	RPMI-7951	Homo sapiens	IC50	=	156.09	nM	PMID[574275]
NPT389	Cell Line	RPMI-8226	Homo sapiens	IC50	=	471.88	nM	PMID[574275]
NPT311	Cell Line	SK-LU-1	Homo sapiens	IC50	=	750.1	nM	PMID[574275]
NPT926	Cell Line	SK-MEL-1	Homo sapiens	IC50	=	138410.24	nM	PMID[574275]
NPT1312	Cell Line	SW1990	Homo sapiens	IC50	=	1617.18	nM	PMID[574275]
NPT2338	Cell Line	SW48	Homo sapiens	IC50	=	1258.27	nM	PMID[574275]
NPT323	Cell Line	SW-620	Homo sapiens	IC50	=	358.55	nM	PMID[574275]
NPT1969	Cell Line	TGW	Homo sapiens	IC50	=	521.64	nM	PMID[574275]
NPT1970	Cell Line	THP-1	Homo sapiens	IC50	=	891.43	nM	PMID[574275]
NPT1971	Cell Line	GI-1	Homo sapiens	IC50	=	568.29	nM	PMID[574275]
NPT1972	Cell Line	GI-ME-N	Homo sapiens	IC50	=	551.75	nM	PMID[574275]
NPT2204	Cell Line	HH	Homo sapiens	IC50	=	1117.63	nM	PMID[574275]
NPT116	Cell Line	HL-60	Homo sapiens	IC50	=	1923.05	nM	PMID[574275]
NPT1973	Cell Line	IST-SL1	Homo sapiens	IC50	=	65198.14	nM	PMID[574275]
NPT1975	Cell Line	KS-1	Homo sapiens	IC50	=	41.5	nM	PMID[574275]
NPT2340	Cell Line	KU-19-19	Homo sapiens	IC50	=	3183.07	nM	PMID[574275]
NPT1976	Cell Line	LNCaP-Clone-FGC	Homo sapiens	IC50	=	41593.88	nM	PMID[574275]
NPT2209	Cell Line	MFH-ino	Homo sapiens	IC50	=	863.85	nM	PMID[574275]
NPT1978	Cell Line	MFM-223	Homo sapiens	IC50	=	898.77	nM	PMID[574275]
NPT1979	Cell Line	NB13	Homo sapiens	IC50	=	316.93	nM	PMID[574275]
NPT639	Cell Line	NCI-H187	Homo sapiens	IC50	=	2359.32	nM	PMID[574275]
NPT1981	Cell Line	NCI-H1882	Homo sapiens	IC50	=	576.09	nM	PMID[574275]
NPT1982	Cell Line	NCI-H1963	Homo sapiens	IC50	=	100.11	nM	PMID[574275]
NPT2342	Cell Line	NCI-H630	Homo sapiens	IC50	=	1303.9	nM	PMID[574275]
NPT1983	Cell Line	NCI-H64	Homo sapiens	IC50	=	547.1	nM	PMID[574275]
NPT2343	Cell Line	NCI-H650	Homo sapiens	IC50	=	665.19	nM	PMID[574275]
NPT1984	Cell Line	ONS-76	Homo sapiens	IC50	=	358.07	nM	PMID[574275]
NPT1986	Cell Line	RPMI 8402	Homo sapiens	IC50	=	1498.31	nM	PMID[574275]
NPT1987	Cell Line	RPMI-8866	Homo sapiens	IC50	=	536.04	nM	PMID[574275]
NPT147	Cell Line	SK-MEL-2	Homo sapiens	IC50	=	6328.9	nM	PMID[574275]
NPT2344	Cell Line	SK-MEL-24	Homo sapiens	IC50	=	1133.44	nM	PMID[574275]
NPT170	Cell Line	SK-MEL-28	Homo sapiens	IC50	=	277189.39	nM	PMID[574275]
NPT2345	Cell Line	SW626	Homo sapiens	IC50	=	635.13	nM	PMID[574275]
NPT1988	Cell Line	SW684	Homo sapiens	IC50	=	777.33	nM	PMID[574275]
NPT384	Cell Line	TK-10	Homo sapiens	IC50	=	1224.02	nM	PMID[574275]
NPT4607	Cell Line	TT	Homo sapiens	IC50	=	1698.76	nM	PMID[574275]
NPT2347	Cell Line	GMS-10	Homo sapiens	IC50	=	11494.56	nM	PMID[574275]
NPT1989	Cell Line	GOTO	Homo sapiens	IC50	=	4588.35	nM	PMID[574275]
NPT2348	Cell Line	HLE	Homo sapiens	IC50	=	88.31	nM	PMID[574275]
NPT2349	Cell Line	HMV-2 cell line		IC50	=	56.4	nM	PMID[574275]
NPT2350	Cell Line	HN	Homo sapiens	IC50	=	1367.64	nM	PMID[574275]
NPT1974	Cell Line	IST-SL2	Homo sapiens	IC50	=	200.14	nM	PMID[574275]
NPT1990	Cell Line	J-RT3-T3-5	Homo sapiens	IC50	=	2086.36	nM	PMID[574275]
NPT1505	Cell Line	J82	Homo sapiens	IC50	=	142.55	nM	PMID[574275]
NPT1991	Cell Line	KU812 cell line		IC50	=	8.306	nM	PMID[574275]
NPT1992	Cell Line	KURAMOCHI	Homo sapiens	IC50	=	3159.36	nM	PMID[574275]
NPT1977	Cell Line	LOUCY	Homo sapiens	IC50	=	586.06	nM	PMID[574275]
NPT390	Cell Line	LOX IMVI	Homo sapiens	IC50	=	411.85	nM	PMID[574275]
NPT1993	Cell Line	LP-1	Homo sapiens	IC50	=	686.37	nM	PMID[574275]
NPT2351	Cell Line	MG-63	Homo sapiens	IC50	=	256.77	nM	PMID[574275]
NPT1994	Cell Line	MHH-CALL-2	Homo sapiens	IC50	=	715.04	nM	PMID[574275]
NPT2352	Cell Line	MHH-ES-1	Homo sapiens	IC50	=	688.56	nM	PMID[574275]
NPT1996	Cell Line	NB5	Homo sapiens	IC50	=	2432.63	nM	PMID[574275]
NPT2353	Cell Line	NCI-H1993	Homo sapiens	IC50	=	2940.26	nM	PMID[574275]
NPT2354	Cell Line	NCI-H2009	Homo sapiens	IC50	=	20.54	nM	PMID[574275]
NPT2356	Cell Line	NCI-H661	Homo sapiens	IC50	=	5428.73	nM	PMID[574275]
NPT1396	Cell Line	NCI-H69	Homo sapiens	IC50	=	6713.8	nM	PMID[574275]
NPT1985	Cell Line	OPM-2	Homo sapiens	IC50	=	343.26	nM	PMID[574275]
NPT1997	Cell Line	OS-RC-2	Homo sapiens	IC50	=	313.89	nM	PMID[574275]
NPT377	Cell Line	OVCAR-3	Homo sapiens	IC50	=	382.81	nM	PMID[574275]
NPT1998	Cell Line	RS4-11	Homo sapiens	IC50	=	416.76	nM	PMID[574275]
NPT2357	Cell Line	RT-112	Homo sapiens	IC50	=	70.37	nM	PMID[574275]
NPT2358	Cell Line	SK-MEL3	Homo sapiens	IC50	=	2642.21	nM	PMID[574275]
NPT2359	Cell Line	SK-MEL-30	Homo sapiens	IC50	=	694.8	nM	PMID[574275]
NPT2360	Cell Line	SW756	Homo sapiens	IC50	=	761.77	nM	PMID[574275]
NPT2361	Cell Line	SW780	Homo sapiens	IC50	=	405.52	nM	PMID[574275]
NPT1999	Cell Line	TUR	Homo sapiens	IC50	=	465.99	nM	PMID[574275]
NPT2362	Cell Line	TYK-nu	Homo sapiens	IC50	=	1152.13	nM	PMID[574275]
NPT2363	Cell Line	U-118-MG	Homo sapiens	IC50	=	841.85	nM	PMID[574275]
NPT2364	Cell Line	GP5d	Homo sapiens	IC50	=	1337.76	nM	PMID[574275]
NPT2000	Cell Line	GR-ST	Homo sapiens	IC50	=	102.18	nM	PMID[574275]
NPT2365	Cell Line	HO-1-N-1	Homo sapiens	IC50	=	462.12	nM	PMID[574275]
NPT379	Cell Line	HOP-62	Homo sapiens	IC50	=	1160.87	nM	PMID[574275]
NPT2001	Cell Line	JAR	Homo sapiens	IC50	=	3262.95	nM	PMID[574275]
NPT2366	Cell Line	JEG-3	Homo sapiens	IC50	=	3171.65	nM	PMID[574275]
NPT2002	Cell Line	KY821	Homo sapiens	IC50	=	746.85	nM	PMID[574275]
NPT2367	Cell Line	KYSE-140	Homo sapiens	IC50	=	373.93	nM	PMID[574275]
NPT2003	Cell Line	LS-1034	Homo sapiens	IC50	=	2747.15	nM	PMID[574275]
NPT2004	Cell Line	LS-123	Homo sapiens	IC50	=	537.66	nM	PMID[574275]
NPT2005	Cell Line	MHH-NB-11	Homo sapiens	IC50	=	485.95	nM	PMID[574275]
NPT2006	Cell Line	MHH-PREB-1	Homo sapiens	IC50	=	251.57	nM	PMID[574275]
NPT2007	Cell Line	NB6	Homo sapiens	IC50	=	454.4	nM	PMID[574275]
NPT2368	Cell Line	NCI-H2030	Homo sapiens	IC50	=	562.65	nM	PMID[574275]
NPT2369	Cell Line	NCI-H2052	Homo sapiens	IC50	=	61.13	nM	PMID[574275]
NPT2010	Cell Line	NCI-H716	Homo sapiens	IC50	=	1136510.63	nM	PMID[574275]
NPT2011	Cell Line	NCI-H719	Homo sapiens	IC50	=	2611.26	nM	PMID[574275]
NPT2012	Cell Line	NCI-H720	Homo sapiens	IC50	=	1136712.95	nM	PMID[574275]
NPT456	Cell Line	OVCAR-4	Homo sapiens	IC50	=	669.55	nM	PMID[574275]
NPT382	Cell Line	OVCAR-5	Homo sapiens	IC50	=	1123.89	nM	PMID[574275]
NPT4608	Cell Line	RT-4	Homo sapiens	IC50	=	10121.92	nM	PMID[574275]
NPT2370	Cell Line	RVH-421	Homo sapiens	IC50	=	1467.47	nM	PMID[574275]
NPT406	Cell Line	RXF 393	Homo sapiens	IC50	=	749.01	nM	PMID[574275]
NPT1506	Cell Line	SK-MES-1	Homo sapiens	IC50	=	6286.32	nM	PMID[574275]
NPT2013	Cell Line	SK-MM-2	Homo sapiens	IC50	=	498.97	nM	PMID[574275]
NPT2371	Cell Line	SW837	Homo sapiens	IC50	=	19784.09	nM	PMID[574275]
NPT2014	Cell Line	SW872	Homo sapiens	IC50	=	367.48	nM	PMID[574275]
NPT1045	Cell Line	U2OS	Homo sapiens	IC50	=	597438.89	nM	PMID[574275]
NPT2015	Cell Line	U-266	Homo sapiens	IC50	=	675.16	nM	PMID[574275]
NPT2016	Cell Line	ES6	Homo sapiens	IC50	=	7878.52	nM	PMID[574275]
NPT2017	Cell Line	ES7	Homo sapiens	IC50	=	548.49	nM	PMID[574275]
NPT2018	Cell Line	GT3TKB	Homo sapiens	IC50	=	345.5	nM	PMID[574275]
NPT372	Cell Line	HOP-92	Homo sapiens	IC50	=	2010.24	nM	PMID[574275]
NPT307	Cell Line	HOS	Homo sapiens	IC50	=	186.08	nM	PMID[574275]
NPT2019	Cell Line	JVM-2	Homo sapiens	IC50	=	3868.13	nM	PMID[574275]
NPT2020	Cell Line	JVM-3	Homo sapiens	IC50	=	913180.9	nM	PMID[574275]
NPT2373	Cell Line	KYSE-150 cell line		IC50	=	901.94	nM	PMID[574275]
NPT2374	Cell Line	KYSE-180	Homo sapiens	IC50	=	1010.32	nM	PMID[574275]
NPT2021	Cell Line	LS-411N	Homo sapiens	IC50	=	3189.61	nM	PMID[574275]
NPT783	Cell Line	MIA PaCa-2	Homo sapiens	IC50	=	276.49	nM	PMID[574275]
NPT2375	Cell Line	MKN-1	Homo sapiens	IC50	=	235.76	nM	PMID[574275]
NPT2008	Cell Line	NB69	Homo sapiens	IC50	=	212.73	nM	PMID[574275]
NPT2009	Cell Line	NCI-H2081	Homo sapiens	IC50	=	1524.77	nM	PMID[574275]
NPT2377	Cell Line	NCI-H2087	Homo sapiens	IC50	=	440.72	nM	PMID[574275]
NPT2024	Cell Line	NCI-H209	Homo sapiens	IC50	=	12309.4	nM	PMID[574275]
NPT2378	Cell Line	NCI-H727	Homo sapiens	IC50	=	638.3	nM	PMID[574275]
NPT2025	Cell Line	NCI-H747	Homo sapiens	IC50	=	441.39	nM	PMID[574275]
NPT381	Cell Line	OVCAR-8	Homo sapiens	IC50	=	460.05	nM	PMID[574275]
NPT2379	Cell Line	P12-Ichikawa	Homo sapiens	IC50	=	1388.36	nM	PMID[574275]
NPT80	Cell Line	Raji	Homo sapiens	IC50	=	631.17	nM	PMID[574275]
NPT2026	Cell Line	Ramos-2G6-4C10	Homo sapiens	IC50	=	315.03	nM	PMID[574275]
NPT2380	Cell Line	SK-N-AS	Homo sapiens	IC50	=	1786.2	nM	PMID[574275]
NPT2027	Cell Line	SK-N-DZ	Homo sapiens	IC50	=	1803.2	nM	PMID[574275]
NPT2382	Cell Line	SW948	Homo sapiens	IC50	=	11909.0	nM	PMID[574275]
NPT2030	Cell Line	U-698-M	Homo sapiens	IC50	=	300.87	nM	PMID[574275]
NPT1535	Cell Line	U-87 MG	Homo sapiens	IC50	=	1275.78	nM	PMID[574275]
NPT2031	Cell Line	ES8	Homo sapiens	IC50	=	777.79	nM	PMID[574275]
NPT2383	Cell Line	ESS-1	Homo sapiens	IC50	=	34139.91	nM	PMID[574275]
NPT2891	Cell Line	H4	Homo sapiens	IC50	=	283.93	nM	PMID[574275]
NPT2032	Cell Line	HAL-01	Homo sapiens	IC50	=	195.73	nM	PMID[574275]
NPT2384	Cell Line	HPAF-II	Homo sapiens	IC50	=	1266.25	nM	PMID[574275]
NPT924	Cell Line	HSC-2	Homo sapiens	IC50	=	223.18	nM	PMID[574275]
NPT2385	Cell Line	HSC-3	Homo sapiens	IC50	=	336.66	nM	PMID[574275]
NPT2033	Cell Line	JIYOYE	Homo sapiens	IC50	=	1387.92	nM	PMID[574275]
NPT111	Cell Line	K562	Homo sapiens	IC50	=	106057.88	nM	PMID[574275]
NPT2386	Cell Line	KYSE-270	Homo sapiens	IC50	=	216.92	nM	PMID[574275]
NPT2387	Cell Line	KYSE-410	Homo sapiens	IC50	=	752.42	nM	PMID[574275]
NPT2395	Cell Line	KYSE-450	Homo sapiens	IC50	=	138.15	nM	PMID[574275]
NPT2022	Cell Line	LS-513	Homo sapiens	IC50	=	1477.97	nM	PMID[574275]
NPT2034	Cell Line	LU-134-A	Homo sapiens	IC50	=	809.71	nM	PMID[574275]
NPT1179	Cell Line	MKN-28	Homo sapiens	IC50	=	616.87	nM	PMID[574275]
NPT1097	Cell Line	MKN-45	Homo sapiens	IC50	=	608.39	nM	PMID[574275]
NPT2398	Cell Line	MKN-7	Homo sapiens	IC50	=	2205.51	nM	PMID[574275]
NPT2035	Cell Line	NCCIT	Homo sapiens	IC50	=	517.16	nM	PMID[574275]
NPT2036	Cell Line	NCI-H1092	Homo sapiens	IC50	=	1393.11	nM	PMID[574275]
NPT2390	Cell Line	NCI-H2122	Homo sapiens	IC50	=	27553.9	nM	PMID[574275]
NPT1082	Cell Line	NCI-H2126	Homo sapiens	IC50	=	15645.4	nM	PMID[574275]
NPT2038	Cell Line	NCI-H748	Homo sapiens	IC50	=	1782.46	nM	PMID[574275]
NPT2391	Cell Line	NCI-H810	Homo sapiens	IC50	=	502.62	nM	PMID[574275]
NPT2040	Cell Line	P30-OHK	Homo sapiens	IC50	=	220.48	nM	PMID[574275]
NPT2041	Cell Line	P31-FUJ	Homo sapiens	IC50	=	2066.09	nM	PMID[574275]
NPT2400	Cell Line	PA-1	Homo sapiens	IC50	=	201.28	nM	PMID[574275]
NPT2392	Cell Line	S-117	Homo sapiens	IC50	=	387.1	nM	PMID[574275]
NPT2393	Cell Line	SAS	Homo sapiens	IC50	=	853.74	nM	PMID[574275]
NPT2028	Cell Line	SK-N-FI	Homo sapiens	IC50	=	7693.54	nM	PMID[574275]
NPT2043	Cell Line	SK-NEP-1	Homo sapiens	IC50	=	1081.12	nM	PMID[574275]
NPT2029	Cell Line	SW 954	Homo sapiens	IC50	=	466.71	nM	PMID[574275]
NPT2044	Cell Line	SW 962	Homo sapiens	IC50	=	568.3	nM	PMID[574275]
NPT371	Cell Line	UO-31	Homo sapiens	IC50	=	770.84	nM	PMID[574275]
NPT380	Cell Line	U-251	Homo sapiens	IC50	=	1432.46	nM	PMID[574275]
NPT2045	Cell Line	ETK-1	Homo sapiens	IC50	=	2445.68	nM	PMID[574275]
NPT2047	Cell Line	HC-1	Homo sapiens	IC50	=	17215.51	nM	PMID[574275]
NPT4609	Cell Line	HCC1143	Homo sapiens	IC50	=	529.69	nM	PMID[574275]
NPT2394	Cell Line	HSC-4	Homo sapiens	IC50	=	2118.83	nM	PMID[574275]
NPT2049	Cell Line	HT	Homo sapiens	IC50	=	1087.45	nM	PMID[574275]
NPT2050	Cell Line	K052	Homo sapiens	IC50	=	1098.89	nM	PMID[574275]
NPT2051	Cell Line	K5	Homo sapiens	IC50	=	734.38	nM	PMID[574275]
NPT2396	Cell Line	KYSE-510	Homo sapiens	IC50	=	252.7	nM	PMID[574275]
NPT2397	Cell Line	KYSE-520 cell line		IC50	=	598.42	nM	PMID[574275]
NPT2053	Cell Line	LU-139	Homo sapiens	IC50	=	6264.09	nM	PMID[574275]
NPT2054	Cell Line	LU-165	Homo sapiens	IC50	=	634.05	nM	PMID[574275]
NPT2055	Cell Line	ML-2	Homo sapiens	IC50	=	617.74	nM	PMID[574275]
NPT2057	Cell Line	NCI-H1155	Homo sapiens	IC50	=	1998891.39	nM	PMID[574275]
NPT2059	Cell Line	NCI-H2141	Homo sapiens	IC50	=	1711.56	nM	PMID[574275]
NPT2399	Cell Line	NCI-H2170	Homo sapiens	IC50	=	1717.23	nM	PMID[574275]
NPT2039	Cell Line	NCI-H82	Homo sapiens	IC50	=	407349.28	nM	PMID[574275]
NPT4610	Cell Line	NCI-H838	Homo sapiens	IC50	=	136106.82	nM	PMID[574275]
NPT2061	Cell Line	NCI-H889	Homo sapiens	IC50	=	1636835.36	nM	PMID[574275]
NPT2401	Cell Line	PANC-03-27	Homo sapiens	IC50	=	167.4	nM	PMID[574275]
NPT2402	Cell Line	PANC-08-13	Homo sapiens	IC50	=	10430.49	nM	PMID[574275]
NPT2042	Cell Line	SBC-1	Homo sapiens	IC50	=	12149.22	nM	PMID[574275]
NPT2403	Cell Line	SBC-5	Homo sapiens	IC50	=	215.46	nM	PMID[574275]
NPT146	Cell Line	SK-OV-3	Homo sapiens	IC50	=	1560.3	nM	PMID[574275]
NPT2063	Cell Line	SK-PN-DW	Homo sapiens	IC50	=	36.55	nM	PMID[574275]
NPT2404	Cell Line	SW982	Homo sapiens	IC50	=	60.23	nM	PMID[574275]
NPT2405	Cell Line	SAOS-2	Homo sapiens	IC50	=	2367.35	nM	PMID[574275]
NPT2245	Cell Line	SiHa	Homo sapiens	IC50	=	18601.72	nM	PMID[574275]
NPT403	Cell Line	UACC-257	Homo sapiens	IC50	=	26356.58	nM	PMID[574275]
NPT398	Cell Line	UACC-62	Homo sapiens	IC50	=	1229.98	nM	PMID[574275]
NPT2046	Cell Line	EVSA-T	Homo sapiens	IC50	=	409.8	nM	PMID[574275]
NPT2065	Cell Line	EW-1	Homo sapiens	IC50	=	843.9	nM	PMID[574275]
NPT2048	Cell Line	HCC1187	Homo sapiens	IC50	=	1019.79	nM	PMID[574275]
NPT2406	Cell Line	HCC1395	Homo sapiens	IC50	=	15686.74	nM	PMID[574275]
NPT2407	Cell Line	HCC1419	Homo sapiens	IC50	=	1689.76	nM	PMID[574275]
NPT453	Cell Line	HT-1080	Homo sapiens	IC50	=	259.95	nM	PMID[574275]
NPT658	Cell Line	HT1197	Homo sapiens	IC50	=	275.82	nM	PMID[574275]
NPT2419	Cell Line	HT-1376	Homo sapiens	IC50	=	915.31	nM	PMID[574275]
NPT2052	Cell Line	KALS-1	Homo sapiens	IC50	=	1317.29	nM	PMID[574275]
NPT2067	Cell Line	KARPAS-299	Homo sapiens	IC50	=	799.41	nM	PMID[574275]
NPT2408	Cell Line	KYSE-70 cell line		IC50	=	2415.66	nM	PMID[574275]
NPT2068	Cell Line	L-363	Homo sapiens	IC50	=	75850.1	nM	PMID[574275]
NPT2069	Cell Line	Lu-65	Homo sapiens	IC50	=	221073.67	nM	PMID[574275]
NPT2409	Cell Line	LU-99A	Homo sapiens	IC50	=	1295.65	nM	PMID[574275]
NPT2056	Cell Line	MLMA	Homo sapiens	IC50	=	539.08	nM	PMID[574275]
NPT2071	Cell Line	MMAC-SF	Homo sapiens	IC50	=	751.96	nM	PMID[574275]
NPT2410	Cell Line	NCI-H1299	Homo sapiens	IC50	=	1071.94	nM	PMID[574275]
NPT2073	Cell Line	NCI-H1304	Homo sapiens	IC50	=	184889.62	nM	PMID[574275]
NPT2060	Cell Line	NCI-H2171	Homo sapiens	IC50	=	908.96	nM	PMID[574275]
NPT2075	Cell Line	NCI-H2196	Homo sapiens	IC50	=	654.27	nM	PMID[574275]
NPT2076	Cell Line	NCI-H2227	Homo sapiens	IC50	=	4886.99	nM	PMID[574275]
NPT2411	Cell Line	NCI-H2228	Homo sapiens	IC50	=	900.95	nM	PMID[574275]
NPT465	Cell Line	NCI-N87	Homo sapiens	IC50	=	2942.3	nM	PMID[574275]
NPT788	Cell Line	SNU1	Homo sapiens	IC50	=	1602.2	nM	PMID[574275]
NPT2412	Cell Line	Panc1005	Homo sapiens	IC50	=	415.63	nM	PMID[574275]
NPT2413	Cell Line	PC-14	Homo sapiens	IC50	=	1507.16	nM	PMID[574275]
NPT2062	Cell Line	SCC-15	Homo sapiens	IC50	=	650.5	nM	PMID[574275]
NPT2414	Cell Line	SCC-25	Homo sapiens	IC50	=	382.64	nM	PMID[574275]
NPT2078	Cell Line	SK-UT-1	Homo sapiens	IC50	=	7.438	nM	PMID[574275]
NPT2415	Cell Line	SKG-IIIa	Homo sapiens	IC50	=	4388.27	nM	PMID[574275]
NPT550	Cell Line	T-24	Homo sapiens	IC50	=	2462.32	nM	PMID[574275]
NPT396	Cell Line	T47D	Homo sapiens	IC50	=	223.06	nM	PMID[574275]
NPT2064	Cell Line	UACC-812	Homo sapiens	IC50	=	5077.15	nM	PMID[574275]
NPT2416	Cell Line	UACC-893	Homo sapiens	IC50	=	119208.02	nM	PMID[574275]
NPT2417	Cell Line	UMUC3	Homo sapiens	IC50	=	967.27	nM	PMID[574275]
NPT2066	Cell Line	EW-11	Homo sapiens	IC50	=	447.16	nM	PMID[574275]
NPT2080	Cell Line	EW-13	Homo sapiens	IC50	=	266.74	nM	PMID[574275]
NPT2418	Cell Line	HCC1569	Homo sapiens	IC50	=	809.94	nM	PMID[574275]
NPT2081	Cell Line	HCC1599	Homo sapiens	IC50	=	388.27	nM	PMID[574275]
NPT2082	Cell Line	HT-144	Homo sapiens	IC50	=	561.17	nM	PMID[574275]
NPT139	Cell Line	HT-29	Homo sapiens	IC50	=	644.57	nM	PMID[574275]
NPT2083	Cell Line	KARPAS-422	Homo sapiens	IC50	=	26611.7	nM	PMID[574275]
NPT2084	Cell Line	KARPAS-45	Homo sapiens	IC50	=	9989.05	nM	PMID[574275]
NPT2086	Cell Line	L-428	Homo sapiens	IC50	=	1205.02	nM	PMID[574275]
NPT2087	Cell Line	L-540	Homo sapiens	IC50	=	4900.04	nM	PMID[574275]
NPT2070	Cell Line	LXF-289 cell line		IC50	=	3271.56	nM	PMID[574275]
NPT114	Cell Line	LoVo	Homo sapiens	IC50	=	1335.09	nM	PMID[574275]
NPT2072	Cell Line	MN-60	Homo sapiens	IC50	=	347.88	nM	PMID[574275]
NPT2074	Cell Line	NCI-H1355	Homo sapiens	IC50	=	2822.51	nM	PMID[574275]
NPT2089	Cell Line	NCI-H1395	Homo sapiens	IC50	=	971830.1	nM	PMID[574275]
NPT405	Cell Line	NCI-H226	Homo sapiens	IC50	=	645.17	nM	PMID[574275]
NPT2090	Cell Line	SNU-16	Homo sapiens	IC50	=	5100648.67	nM	PMID[574275]
NPT2091	Cell Line	SNU-5	Homo sapiens	IC50	=	9536.71	nM	PMID[574275]
NPT306	Cell Line	PC-3	Homo sapiens	IC50	=	858.79	nM	PMID[574275]
NPT2093	Cell Line	PF-382	Homo sapiens	IC50	=	789.51	nM	PMID[574275]
NPT2421	Cell Line	PFSK-1	Homo sapiens	IC50	=	76572.12	nM	PMID[574275]
NPT2077	Cell Line	SCC-3	Homo sapiens	IC50	=	1003.43	nM	PMID[574275]
NPT2422	Cell Line	SCC-4	Homo sapiens	IC50	=	440.6	nM	PMID[574275]
NPT2423	Cell Line	SCC-9	Homo sapiens	IC50	=	196.75	nM	PMID[574275]
NPT368	Cell Line	SN12C	Homo sapiens	IC50	=	1762.58	nM	PMID[574275]
NPT392	Cell Line	SNB-75	Homo sapiens	IC50	=	745.95	nM	PMID[574275]
NPT2424	Cell Line	T84	Homo sapiens	IC50	=	14520.28	nM	PMID[574275]
NPT1125	Cell Line	T98G	Homo sapiens	IC50	=	1082.08	nM	PMID[574275]
NPT2425	Cell Line	UMC-11	Homo sapiens	IC50	=	46792.08	nM	PMID[574275]
NPT2096	Cell Line	VA-ES-BJ	Homo sapiens	IC50	=	400.58	nM	PMID[574275]
NPT2097	Cell Line	EW-16	Homo sapiens	IC50	=	299.15	nM	PMID[574275]
NPT2098	Cell Line	EW-18	Homo sapiens	IC50	=	528.62	nM	PMID[574275]
NPT2426	Cell Line	HCC1806	Homo sapiens	IC50	=	1270.34	nM	PMID[574275]
NPT1884	Cell Line	HCC1937	Homo sapiens	IC50	=	1662.86	nM	PMID[574275]
NPT2427	Cell Line	HCC1954	Homo sapiens	IC50	=	901.82	nM	PMID[574275]
NPT2428	Cell Line	HT-3	Homo sapiens	IC50	=	948.27	nM	PMID[574275]
NPT2429	Cell Line	HT55	Homo sapiens	IC50	=	1689.62	nM	PMID[574275]
NPT2085	Cell Line	Kasumi 1		IC50	=	123.71	nM	PMID[574275]
NPT2099	Cell Line	KE-37	Homo sapiens	IC50	=	244.45	nM	PMID[574275]
NPT2100	Cell Line	KG-1		IC50	=	1597.73	nM	PMID[574275]
NPT1358	Cell Line	LAMA-84	Homo sapiens	IC50	=	1209.53	nM	PMID[574275]
NPT2101	Cell Line	LAN-6	Homo sapiens	IC50	=	3219.16	nM	PMID[574275]
NPT2430	Cell Line	M059J	Homo sapiens	IC50	=	134.19	nM	PMID[574275]
NPT387	Cell Line	M14	Homo sapiens	IC50	=	1492.69	nM	PMID[574275]
NPT2088	Cell Line	MOLT-16	Homo sapiens	IC50	=	2762.98	nM	PMID[574275]
NPT112	Cell Line	MOLT-4	Homo sapiens	IC50	=	410.12	nM	PMID[574275]
NPT2104	Cell Line	NCI-H1417	Homo sapiens	IC50	=	815.92	nM	PMID[574275]
NPT2105	Cell Line	NCI-H1436	Homo sapiens	IC50	=	603.96	nM	PMID[574275]
NPT2431	Cell Line	NCI-H1437	Homo sapiens	IC50	=	1557.48	nM	PMID[574275]
NPT370	Cell Line	NCI-H23	Homo sapiens	IC50	=	34982.99	nM	PMID[574275]
NPT2432	Cell Line	NCI-H2342	Homo sapiens	IC50	=	134.45	nM	PMID[574275]
NPT2092	Cell Line	NEC8	Homo sapiens	IC50	=	839.9	nM	PMID[574275]
NPT2106	Cell Line	NH-12	Homo sapiens	IC50	=	850.19	nM	PMID[574275]
NPT4611	Cell Line	PLC-PRF-5	Homo sapiens	IC50	=	1815.79	nM	PMID[574275]
NPT2107	Cell Line	PSN1	Homo sapiens	IC50	=	71023.8	nM	PMID[574275]
NPT2109	Cell Line	SCH	Homo sapiens	IC50	=	195008.47	nM	PMID[574275]
NPT2110	Cell Line	SCLC-21H	Homo sapiens	IC50	=	1364.86	nM	PMID[574275]
NPT4612	Cell Line	SNG-M	Homo sapiens	IC50	=	272.37	nM	PMID[574275]
NPT890	Cell Line	SNU-387	Homo sapiens	IC50	=	1068.57	nM	PMID[574275]
NPT2433	Cell Line	SNU-423	Homo sapiens	IC50	=	163.07	nM	PMID[574275]
NPT2095	Cell Line	TALL-1	Homo sapiens	IC50	=	754677.12	nM	PMID[574275]
NPT2434	Cell Line	TCC-SUP	Homo sapiens	IC50	=	554.45	nM	PMID[574275]
NPT2112	Cell Line	TE-1	Homo sapiens	IC50	=	15796.45	nM	PMID[574275]
NPT2435	Cell Line	VM-CUB-1	Homo sapiens	IC50	=	1028.56	nM	PMID[574275]
NPT2436	Cell Line	VMRC-RCZ	Homo sapiens	IC50	=	546.67	nM	PMID[574275]
NPT1653	Cell Line	WM-115	Homo sapiens	IC50	=	10644.2	nM	PMID[574275]
NPT2113	Cell Line	EW-24	Homo sapiens	IC50	=	14592.71	nM	PMID[574275]
NPT2115	Cell Line	HCC2157	Homo sapiens	IC50	=	337.83	nM	PMID[574275]
NPT2116	Cell Line	HCC2218	Homo sapiens	IC50	=	496.03	nM	PMID[574275]
NPT2438	Cell Line	HTC-C3	Homo sapiens	IC50	=	542.37	nM	PMID[574275]
NPT2117	Cell Line	HuTu80	Homo sapiens	IC50	=	370.2	nM	PMID[574275]
NPT2118	Cell Line	KGN	Homo sapiens	IC50	=	1307.27	nM	PMID[574275]
NPT2120	Cell Line	LB1047-RCC	Homo sapiens	IC50	=	302.44	nM	PMID[574275]
NPT2121	Cell Line	LB2241-RCC	Homo sapiens	IC50	=	1288.29	nM	PMID[574275]
NPT2102	Cell Line	MC-CAR	Homo sapiens	IC50	=	813.62	nM	PMID[574275]
NPT2439	Cell Line	MC-IXC	Homo sapiens	IC50	=	387.38	nM	PMID[574275]
NPT2122	Cell Line	MC116	Homo sapiens	IC50	=	1786.36	nM	PMID[574275]
NPT2103	Cell Line	MONO-MAC-6	Homo sapiens	IC50	=	244.77	nM	PMID[574275]
NPT2123	Cell Line	MPP-89	Homo sapiens	IC50	=	857.25	nM	PMID[574275]
NPT2125	Cell Line	NCI-H1522	Homo sapiens	IC50	=	519.44	nM	PMID[574275]
NPT2440	Cell Line	NCI-H1563	Homo sapiens	IC50	=	626.38	nM	PMID[574275]
NPT2441	Cell Line	NCI-H2347	Homo sapiens	IC50	=	967.81	nM	PMID[574275]
NPT2442	Cell Line	NCI-H2405	Homo sapiens	IC50	=	674.53	nM	PMID[574275]
NPT2450	Cell Line	NCI-H2452	Homo sapiens	IC50	=	225928.37	nM	PMID[574275]
NPT2126	Cell Line	NKM-1	Homo sapiens	IC50	=	101.2	nM	PMID[574275]
NPT2127	Cell Line	NMC-G1	Homo sapiens	IC50	=	1297.14	nM	PMID[574275]
NPT2108	Cell Line	QIMR-WIL	Homo sapiens	IC50	=	181.89	nM	PMID[574275]
NPT2128	Cell Line	RCC10RGB	Homo sapiens	IC50	=	1563.9	nM	PMID[574275]
NPT2111	Cell Line	SF-126	Homo sapiens	IC50	=	772.97	nM	PMID[574275]
NPT395	Cell Line	SF-268	Homo sapiens	IC50	=	5577.43	nM	PMID[574275]
NPT2443	Cell Line	SNU-449	Homo sapiens	IC50	=	813.25	nM	PMID[574275]
NPT4613	Cell Line	SNU-475	Homo sapiens	IC50	=	14058.92	nM	PMID[574275]
NPT2129	Cell Line	SNU-C1	Homo sapiens	IC50	=	722279.37	nM	PMID[574275]
NPT2130	Cell Line	TE-10	Homo sapiens	IC50	=	986.09	nM	PMID[574275]
NPT2131	Cell Line	WSU-NHL	Homo sapiens	IC50	=	260.33	nM	PMID[574275]
NPT2444	Cell Line	YAPC	Homo sapiens	IC50	=	243833.84	nM	PMID[574275]
NPT2114	Cell Line	EW-3	Homo sapiens	IC50	=	721.5	nM	PMID[574275]
NPT4614	Cell Line	EW-7	Homo sapiens	IC50	=	1290.91	nM	PMID[574275]
NPT2132	Cell Line	EOL1	Homo sapiens	IC50	=	508.75	nM	PMID[574275]
NPT391	Cell Line	HCC 2998	Homo sapiens	IC50	=	46035.14	nM	PMID[574275]
NPT2446	Cell Line	HCC38	Homo sapiens	IC50	=	786.51	nM	PMID[574275]
NPT402	Cell Line	Hs-578T	Homo sapiens	IC50	=	6223.4	nM	PMID[574275]
NPT2447	Cell Line	HuCCT-1	Homo sapiens	IC50	=	483.02	nM	PMID[574275]
NPT1229	Cell Line	Huh-7	Homo sapiens	IC50	=	1955.26	nM	PMID[574275]
NPT2119	Cell Line	KINGS-1	Homo sapiens	IC50	=	14077.46	nM	PMID[574275]
NPT2448	Cell Line	KLE	Homo sapiens	IC50	=	684.66	nM	PMID[574275]
NPT2134	Cell Line	LB2518-MEL	Homo sapiens	IC50	=	3283.31	nM	PMID[574275]
NPT83	Cell Line	MCF7	Homo sapiens	IC50	=	434.85	nM	PMID[574275]
NPT2136	Cell Line	MDA-MB-134-VI	Homo sapiens	IC50	=	709.4	nM	PMID[574275]
NPT2463	Cell Line	MDA-MB-157	Homo sapiens	IC50	=	636.63	nM	PMID[574275]
NPT2124	Cell Line	MRK-nu-1	Homo sapiens	IC50	=	101.93	nM	PMID[574275]
NPT2137	Cell Line	MS-1	Homo sapiens	IC50	=	1772.48	nM	PMID[574275]
NPT2138	Cell Line	MSTO-211H	Homo sapiens	IC50	=	603751.69	nM	PMID[574275]
NPT2139	Cell Line	NCI-H1581	Homo sapiens	IC50	=	89965.84	nM	PMID[574275]
NPT4615	Cell Line	NCI-H1618	Homo sapiens	IC50	=	2019.66	nM	PMID[574275]
NPT2451	Cell Line	NCI-H28	Homo sapiens	IC50	=	1008.35	nM	PMID[574275]
NPT2452	Cell Line	NCI-H292		IC50	=	853.29	nM	PMID[574275]
NPT2140	Cell Line	NOMO-1	Homo sapiens	IC50	=	1155.91	nM	PMID[574275]
NPT2141	Cell Line	NOS-1	Homo sapiens	IC50	=	282233.85	nM	PMID[574275]
NPT2453	Cell Line	RCM-1	Homo sapiens	IC50	=	2002.19	nM	PMID[574275]
NPT2454	Cell Line	RD	Homo sapiens	IC50	=	449.06	nM	PMID[574275]
NPT399	Cell Line	SF-295	Homo sapiens	IC50	=	664.18	nM	PMID[574275]
NPT374	Cell Line	SF-539	Homo sapiens	IC50	=	856.82	nM	PMID[574275]
NPT2455	Cell Line	SNU-C2B	Homo sapiens	IC50	=	24926.79	nM	PMID[574275]
NPT385	Cell Line	SR	Homo sapiens	IC50	=	140.73	nM	PMID[574275]
NPT2456	Cell Line	TE-11	Homo sapiens	IC50	=	4014.26	nM	PMID[574275]
NPT2144	Cell Line	TE-12	Homo sapiens	IC50	=	2343.25	nM	PMID[574275]
NPT2457	Cell Line	YKG-1	Homo sapiens	IC50	=	228.91	nM	PMID[574275]
NPT2146	Cell Line	YT	Homo sapiens	IC50	=	383.89	nM	PMID[574275]
NPT1216	Cell Line	FaDu	Homo sapiens	IC50	=	1766.39	nM	PMID[574275]
NPT2458	Cell Line	FTC-133	Homo sapiens	IC50	=	5743.15	nM	PMID[574275]
NPT2459	Cell Line	HCC70	Homo sapiens	IC50	=	2008.36	nM	PMID[574275]
NPT2460	Cell Line	HCE-4	Homo sapiens	IC50	=	388.84	nM	PMID[574275]
NPT2461	Cell Line	HuO-3N1	Homo sapiens	IC50	=	4433.41	nM	PMID[574275]
NPT2462	Cell Line	HuO9	Homo sapiens	IC50	=	1658.0	nM	PMID[574275]
NPT2133	Cell Line	KM-H2	Homo sapiens	IC50	=	1036.17	nM	PMID[574275]
NPT386	Cell Line	KM12	Homo sapiens	IC50	=	739.71	nM	PMID[574275]
NPT2135	Cell Line	LB373-MEL-D	Homo sapiens	IC50	=	390.74	nM	PMID[574275]
NPT2147	Cell Line	LB647-SCLC	Homo sapiens	IC50	=	232.78	nM	PMID[574275]
NPT2148	Cell Line	LB771-HNC	Homo sapiens	IC50	=	20788.0	nM	PMID[574275]
NPT2464	Cell Line	MDA-MB-175-VII	Homo sapiens	IC50	=	2053.07	nM	PMID[574275]
NPT82	Cell Line	MDA-MB-231	Homo sapiens	IC50	=	1015.44	nM	PMID[574275]
NPT1649	Cell Line	MV4-11	Homo sapiens	IC50	=	273.63	nM	PMID[574275]
NPT2465	Cell Line	NCI-H1623	Homo sapiens	IC50	=	2727.21	nM	PMID[574275]
NPT2150	Cell Line	NCI-H1648	Homo sapiens	IC50	=	11147.41	nM	PMID[574275]
NPT388	Cell Line	NCI-H322M	Homo sapiens	IC50	=	32481.64	nM	PMID[574275]
NPT2151	Cell Line	NCI-H345	Homo sapiens	IC50	=	989.57	nM	PMID[574275]
NPT2466	Cell Line	NCI-H358	Homo sapiens	IC50	=	657.76	nM	PMID[574275]
NPT2152	Cell Line	NTERA-2-cl-D1	Homo sapiens	IC50	=	143.57	nM	PMID[574275]
NPT2477	Cell Line	NUGC-3	Homo sapiens	IC50	=	765.43	nM	PMID[574275]
NPT2142	Cell Line	REH	Homo sapiens	IC50	=	146.96	nM	PMID[574275]
NPT2467	Cell Line	RERF-LC-MS	Homo sapiens	IC50	=	4189.97	nM	PMID[574275]
NPT2153	Cell Line	RH-1	Homo sapiens	IC50	=	719.88	nM	PMID[574275]
NPT2154	Cell Line	SH-4	Homo sapiens	IC50	=	371.35	nM	PMID[574275]
NPT2155	Cell Line	SHP77	Homo sapiens	IC50	=	445.54	nM	PMID[574275]
NPT2143	Cell Line	ST486	Homo sapiens	IC50	=	6.179	nM	PMID[574275]
NPT2156	Cell Line	SU-DHL-1	Homo sapiens	IC50	=	499.22	nM	PMID[574275]
NPT2157	Cell Line	SUP-T1	Homo sapiens	IC50	=	1822.91	nM	PMID[574275]
NPT2481	Cell Line	SW1088	Homo sapiens	IC50	=	699.55	nM	PMID[574275]
NPT2145	Cell Line	TE-15	Homo sapiens	IC50	=	400.31	nM	PMID[574275]
NPT2158	Cell Line	TE-441-T	Homo sapiens	IC50	=	2.238	nM	PMID[574275]
NPT2159	Cell Line	TE-5	Homo sapiens	IC50	=	1004.32	nM	PMID[574275]
NPT2160	Cell Line	no-10	Homo sapiens	IC50	=	290.23	nM	PMID[574275]
NPT2161	Cell Line	no-11	Homo sapiens	IC50	=	805.42	nM	PMID[574275]
NPT2468	Cell Line	G-361	Homo sapiens	IC50	=	473.21	nM	PMID[574275]
NPT2469	Cell Line	G-401	Homo sapiens	IC50	=	234.92	nM	PMID[574275]
NPT2470	Cell Line	G-402	Homo sapiens	IC50	=	881.67	nM	PMID[574275]
NPT2162	Cell Line	HCE-T	Homo sapiens	IC50	=	720.09	nM	PMID[574275]
NPT393	Cell Line	HCT-116	Homo sapiens	IC50	=	386.26	nM	PMID[574275]
NPT2471	Cell Line	HuP-T3	Homo sapiens	IC50	=	833.73	nM	PMID[574275]
NPT2472	Cell Line	HuP-T4	Homo sapiens	IC50	=	1361.78	nM	PMID[574275]
NPT2163	Cell Line	KMOE-2	Homo sapiens	IC50	=	1240.66	nM	PMID[574275]
NPT2164	Cell Line	KMS-12-PE	Homo sapiens	IC50	=	559.38	nM	PMID[574275]
NPT2166	Cell Line	LB831-BLC	Homo sapiens	IC50	=	1916.8	nM	PMID[574275]
NPT2473	Cell Line	MDA-MB-361	Homo sapiens	IC50	=	1732.36	nM	PMID[574275]
NPT2474	Cell Line	MDA-MB-415	Homo sapiens	IC50	=	2276.74	nM	PMID[574275]
NPT2488	Cell Line	MDA-MB-453	Homo sapiens	IC50	=	2518.94	nM	PMID[574275]
NPT2149	Cell Line	MZ1-PC	Homo sapiens	IC50	=	19.28	nM	PMID[574275]
NPT2168	Cell Line	MZ2-MEL	Homo sapiens	IC50	=	385.22	nM	PMID[574275]
NPT1820	Cell Line	NCI-H1650	Homo sapiens	IC50	=	1375.03	nM	PMID[574275]
NPT2475	Cell Line	NCI-H1651	Homo sapiens	IC50	=	22750.27	nM	PMID[574275]
NPT2476	Cell Line	NCI-H441	Homo sapiens	IC50	=	15808.87	nM	PMID[574275]
NPT937	Cell Line	NCI-H446	Homo sapiens	IC50	=	39554.32	nM	PMID[574275]
NPT2478	Cell Line	NY	Homo sapiens	IC50	=	1045.57	nM	PMID[574275]
NPT2479	Cell Line	OAW-28	Homo sapiens	IC50	=	1198.21	nM	PMID[574275]
NPT2170	Cell Line	RKO	Homo sapiens	IC50	=	270.3	nM	PMID[574275]
NPT2171	Cell Line	SIG-M5	Homo sapiens	IC50	=	169.86	nM	PMID[574275]
NPT2172	Cell Line	SIMA	Homo sapiens	IC50	=	2318.43	nM	PMID[574275]
NPT2483	Cell Line	SW13	Homo sapiens	IC50	=	1409.19	nM	PMID[574275]
NPT2173	Cell Line	TE-6	Homo sapiens	IC50	=	2967.91	nM	PMID[574275]
NPT2175	Cell Line	GAK	Homo sapiens	IC50	=	1037.69	nM	PMID[574275]
NPT2484	Cell Line	GAMG	Homo sapiens	IC50	=	1709.71	nM	PMID[574275]
NPT148	Cell Line	HCT-15	Homo sapiens	IC50	=	267.58	nM	PMID[574275]
NPT2176	Cell Line	HD-MY-Z	Homo sapiens	IC50	=	470.14	nM	PMID[574275]
NPT2485	Cell Line	IA-LM	Homo sapiens	IC50	=	2080.5	nM	PMID[574275]
NPT2486	Cell Line	IGR-1	Homo sapiens	IC50	=	153.98	nM	PMID[574275]
NPT458	Cell Line	IGROV-1	Homo sapiens	IC50	=	55.61	nM	PMID[574275]
NPT2165	Cell Line	KNS-42	Homo sapiens	IC50	=	18658.43	nM	PMID[574275]
NPT2178	Cell Line	KNS-81-FD	Homo sapiens	IC50	=	1081.94	nM	PMID[574275]
NPT2167	Cell Line	LB996-RCC	Homo sapiens	IC50	=	191158.51	nM	PMID[574275]
NPT2179	Cell Line	LC-1F	Homo sapiens	IC50	=	409800.31	nM	PMID[574275]
NPT2180	Cell Line	LC-2-ad	Homo sapiens	IC50	=	952.55	nM	PMID[574275]
NPT784	Cell Line	MDA-MB-468	Homo sapiens	IC50	=	966.84	nM	PMID[574275]
NPT1773	Cell Line	ME-180	Homo sapiens	IC50	=	278.91	nM	PMID[574275]
NPT2169	Cell Line	MZ7-mel	Homo sapiens	IC50	=	113.72	nM	PMID[574275]
NPT2489	Cell Line	MeWo	Homo sapiens	IC50	=	517.32	nM	PMID[574275]
NPT2491	Cell Line	NCI-H1693	Homo sapiens	IC50	=	66678.0	nM	PMID[574275]
NPT2183	Cell Line	NCI-H1694	Homo sapiens	IC50	=	840.09	nM	PMID[574275]
NPT397	Cell Line	NCI-H460	Homo sapiens	IC50	=	1277.69	nM	PMID[574275]
NPT2184	Cell Line	NCI-H510A	Homo sapiens	IC50	=	165511.55	nM	PMID[574275]
NPT2492	Cell Line	OAW-42	Homo sapiens	IC50	=	577.68	nM	PMID[574275]
NPT2186	Cell Line	RL	Homo sapiens	IC50	=	464793.4	nM	PMID[574275]
NPT2187	Cell Line	RL95-2	Homo sapiens	IC50	=	719.73	nM	PMID[574275]
NPT2494	Cell Line	RMG-I	Homo sapiens	IC50	=	864.23	nM	PMID[574275]
NPT3467	Cell Line	SJRH30	Homo sapiens	IC50	=	369.2	nM	PMID[574275]
NPT2188	Cell Line	SJSA-1	Homo sapiens	IC50	=	5525.33	nM	PMID[574275]
NPT4616	Cell Line	SK-CO-1	Homo sapiens	IC50	=	2054.9	nM	PMID[574275]
NPT2495	Cell Line	SW1417	Homo sapiens	IC50	=	825.83	nM	PMID[574275]
NPT2496	Cell Line	SW1463	Homo sapiens	IC50	=	8606.36	nM	PMID[574275]
NPT1577	Cell Line	SW1573	Homo sapiens	IC50	=	371.8	nM	PMID[574275]
NPT2174	Cell Line	TE-8	Homo sapiens	IC50	=	1280.63	nM	PMID[574275]
NPT2189	Cell Line	TE-9	Homo sapiens	IC50	=	407.52	nM	PMID[574275]
NPT2190	Cell Line	GB-1	Homo sapiens	IC50	=	1329.99	nM	PMID[574275]
NPT2191	Cell Line	GCIY	Homo sapiens	IC50	=	35.98	nM	PMID[574275]
NPT2177	Cell Line	HDLM-2	Homo sapiens	IC50	=	89557.42	nM	PMID[574275]
NPT2497	Cell Line	HEC-1	Homo sapiens	IC50	=	1134.41	nM	PMID[574275]
NPT2193	Cell Line	IM-9	Homo sapiens	IC50	=	3412.07	nM	PMID[574275]
NPT2194	Cell Line	IMR-5	Homo sapiens	IC50	=	589.4	nM	PMID[574275]
NPT4617	Cell Line	IPC-298	Homo sapiens	IC50	=	557135.23	nM	PMID[574275]
NPT2498	Cell Line	KOSC-2	Homo sapiens	IC50	=	1490.84	nM	PMID[574275]
NPT2499	Cell Line	KP-4	Homo sapiens	IC50	=	500.8	nM	PMID[574275]
NPT2195	Cell Line	LC4-1	Homo sapiens	IC50	=	360.29	nM	PMID[574275]
NPT2500	Cell Line	LCLC-103H cell line		IC50	=	345.6	nM	PMID[574275]
NPT2181	Cell Line	MEG-01	Homo sapiens	IC50	=	451.25	nM	PMID[574275]
NPT2501	Cell Line	MEL-HO	Homo sapiens	IC50	=	148.82	nM	PMID[574275]
NPT2502	Cell Line	MEL-JUSO	Homo sapiens	IC50	=	540.14	nM	PMID[574275]
NPT623	Cell Line	NALM-6	Homo sapiens	IC50	=	2.797	nM	PMID[574275]
NPT2503	Cell Line	NCI-H1703	Homo sapiens	IC50	=	2297.23	nM	PMID[574275]
NPT4618	Cell Line	NCI-H1734	Homo sapiens	IC50	=	6895.11	nM	PMID[574275]
NPT2504	Cell Line	NCI-H1755	Homo sapiens	IC50	=	30252.11	nM	PMID[574275]
NPT2505	Cell Line	NCI-H520		IC50	=	1354.54	nM	PMID[574275]
NPT455	Cell Line	NCI-H522	Homo sapiens	IC50	=	559.79	nM	PMID[574275]
NPT2198	Cell Line	NCI-H524	Homo sapiens	IC50	=	998680.59	nM	PMID[574275]
NPT2185	Cell Line	OCI-AML2	Homo sapiens	IC50	=	298.37	nM	PMID[574275]
NPT2199	Cell Line	OCUB-M	Homo sapiens	IC50	=	865.23	nM	PMID[574275]
NPT2336	Cell Line	OE19	Homo sapiens	IC50	=	807.34	nM	PMID[574275]
NPT2506	Cell Line	RO82-W-1	Homo sapiens	IC50	=	2842.95	nM	PMID[574275]
NPT2507	Cell Line	RPMI-2650	Homo sapiens	IC50	=	374.74	nM	PMID[574275]
NPT1086	Cell Line	SK-HEP1	Homo sapiens	IC50	=	547.51	nM	PMID[574275]
NPT2201	Cell Line	SK-LMS-1	Homo sapiens	IC50	=	108.41	nM	PMID[574275]
NPT2508	Cell Line	SW1710	Homo sapiens	IC50	=	2.91	nM	PMID[574275]
NPT2509	Cell Line	SW1783	Homo sapiens	IC50	=	1068.84	nM	PMID[574275]
NPT2202	Cell Line	TGBC1TKB	Homo sapiens	IC50	=	1428.19	nM	PMID[574275]
NPT2339	Cell Line	TGBC24TKB	Homo sapiens	IC50	=	27882.74	nM	PMID[574275]
NPT2510	Cell Line	GCT	Homo sapiens	IC50	=	1151.53	nM	PMID[574275]
NPT2203	Cell Line	GDM-1	Homo sapiens	IC50	=	2676.06	nM	PMID[574275]
NPT2192	Cell Line	HEL	Homo sapiens	IC50	=	2043.04	nM	PMID[574275]
NPT2511	Cell Line	HGC-27	Homo sapiens	IC50	=	228.34	nM	PMID[574275]
NPT2205	Cell Line	IST-MEL1	Homo sapiens	IC50	=	14955.39	nM	PMID[574275]
NPT2206	Cell Line	IST-MES1	Homo sapiens	IC50	=	1696.61	nM	PMID[574275]
NPT2208	Cell Line	KP-N-YS	Homo sapiens	IC50	=	351.7	nM	PMID[574275]
NPT2512	Cell Line	LCLC-97TM1	Homo sapiens	IC50	=	613.12	nM	PMID[574275]
NPT2513	Cell Line	LK-2	Homo sapiens	IC50	=	8570.71	nM	PMID[574275]
NPT2514	Cell Line	LN-405	Homo sapiens	IC50	=	6914.68	nM	PMID[574275]
NPT2844	Cell Line	MES-SA	Homo sapiens	IC50	=	41.32	nM	PMID[574275]
NPT2515	Cell Line	MFE-280	Homo sapiens	IC50	=	4946.54	nM	PMID[574275]
NPT3882	Cell Line	MFE-296	Homo sapiens	IC50	=	662.44	nM	PMID[574275]
NPT2196	Cell Line	NB1	Homo sapiens	IC50	=	1034.34	nM	PMID[574275]
NPT2210	Cell Line	NB10	Homo sapiens	IC50	=	1343.65	nM	PMID[574275]
NPT2211	Cell Line	NB12	Homo sapiens	IC50	=	666.31	nM	PMID[574275]
NPT2197	Cell Line	NCI-H1770	Homo sapiens	IC50	=	243.14	nM	PMID[574275]
NPT1669	Cell Line	NCI-H1792	Homo sapiens	IC50	=	104969.83	nM	PMID[574275]
NPT2334	Cell Line	NCI-H1793	Homo sapiens	IC50	=	916685.09	nM	PMID[574275]
NPT49	Individual Protein	DNA-(apurinic or apyrimidinic site) lyase	Homo sapiens	Potency	n.a.	7079.5	nM	PMID[574266]
NPT90	Cell Line	DU-145	Homo sapiens	IC50	=	16000.0	nM	PMID[574277]
NPT83	Cell Line	MCF7	Homo sapiens	IC50	=	1800.0	nM	PMID[574277]
NPT111	Cell Line	K562	Homo sapiens	IC50	=	700.0	nM	PMID[574277]
NPT165	Cell Line	HeLa	Homo sapiens	IC50	=	6420.0	nM	PMID[574278]
NPT82	Cell Line	MDA-MB-231	Homo sapiens	IC50	=	3940.0	nM	PMID[574278]
NPT83	Cell Line	MCF7	Homo sapiens	IC50	=	5490.0	nM	PMID[574278]
NPT5420	Cell Line	MCF10	Homo sapiens	IC50	=	4560.0	nM	PMID[574278]
NPT2410	Cell Line	NCI-H1299	Homo sapiens	IC50	=	1880.0	nM	PMID[574279]
NPT165	Cell Line	HeLa	Homo sapiens	IC50	=	2450.0	nM	PMID[574279]
NPT393	Cell Line	HCT-116	Homo sapiens	IC50	=	1840.0	nM	PMID[574279]
NPT6230	Individual Protein	Pyruvate kinase isozymes R/L	Homo sapiens	IC50	=	39250.0	nM	PMID[574279]
NPT52	Individual Protein	Pyruvate kinase isozymes M1/M2	Homo sapiens	IC50	=	12960.0	nM	PMID[574279]
NPT52	Individual Protein	Pyruvate kinase isozymes M1/M2	Homo sapiens	IC50	=	8820.0	nM	PMID[574279]
NPT1821	Individual Protein	Sortase	Staphylococcus aureus	IC50	=	5000.0	nM	PMID[574280]
NPT1821	Individual Protein	Sortase	Staphylococcus aureus	IC50	=	300.0	nM	PMID[574280]
NPT148	Cell Line	HCT-15	Homo sapiens	IC50	=	860.0	nM	PMID[574281]
NPT3140	Cell Line	MGC-803	Homo sapiens	IC50	=	1510.0	nM	PMID[574281]
NPT181	Cell Line	Bel-7402	Homo sapiens	IC50	=	1240.0	nM	PMID[574281]
NPT83	Cell Line	MCF7	Homo sapiens	IC50	=	2400.0	nM	PMID[574281]
NPT52	Individual Protein	Pyruvate kinase isozymes M1/M2	Homo sapiens	IC50	=	10000.0	nM	PMID[574282]
NPT52	Individual Protein	Pyruvate kinase isozymes M1/M2	Homo sapiens	IC50	=	500.0	nM	PMID[574282]
NPT82	Cell Line	MDA-MB-231	Homo sapiens	IC50	=	8750.0	nM	PMID[574283]
NPT65	Cell Line	HepG2	Homo sapiens	IC50	=	6920.0	nM	PMID[574283]
NPT165	Cell Line	HeLa	Homo sapiens	IC50	=	6860.0	nM	PMID[574283]
NPT81	Cell Line	A549	Homo sapiens	IC50	=	3530.0	nM	PMID[574283]
NPT2615	Cell Line	HEK-293T	Homo sapiens	IC50	=	62760.0	nM	PMID[574283]
NPT165	Cell Line	HeLa	Homo sapiens	Activity	=	63.83	%	PMID[574283]
NPT165	Cell Line	HeLa	Homo sapiens	Activity	=	17.42	%	PMID[574283]
NPT165	Cell Line	HeLa	Homo sapiens	Activity	=	18.75	%	PMID[574283]
NPT165	Cell Line	HeLa	Homo sapiens	Activity	=	62.72	%	PMID[574283]
NPT165	Cell Line	HeLa	Homo sapiens	Activity	=	13.25	%	PMID[574283]
NPT165	Cell Line	HeLa	Homo sapiens	Activity	=	24.03	%	PMID[574283]
NPT165	Cell Line	HeLa	Homo sapiens	Activity	=	57.75	%	PMID[574283]
NPT165	Cell Line	HeLa	Homo sapiens	Activity	=	14.13	%	PMID[574283]
NPT165	Cell Line	HeLa	Homo sapiens	Activity	=	28.12	%	PMID[574283]
NPT6230	Individual Protein	Pyruvate kinase isozymes R/L	Homo sapiens	IC50	=	39250.0	nM	PMID[574284]
NPT52	Individual Protein	Pyruvate kinase isozymes M1/M2	Homo sapiens	IC50	=	12960.0	nM	PMID[574284]
NPT52	Individual Protein	Pyruvate kinase isozymes M1/M2	Homo sapiens	IC50	=	8820.0	nM	PMID[574284]
NPT737	Cell Line	HUVEC	Homo sapiens	Inhibition	=	31.77	%	PMID[574285]
NPT3060	Individual Protein	Dual specificity phosphatase Cdc25A	Homo sapiens	IC50	=	220.0	nM	PMID[574286]
NPT1970	Cell Line	THP-1	Homo sapiens	IC50	=	820.0	nM	PMID[574286]
NPT2103	Cell Line	MONO-MAC-6	Homo sapiens	IC50	=	2600.0	nM	PMID[574286]
NPT116	Cell Line	HL-60	Homo sapiens	IC50	=	1200.0	nM	PMID[574286]
NPT2404	Cell Line	SW982	Homo sapiens	IC50	=	2800.0	nM	PMID[574286]
NPT15	Cell Line	Jurkat	Homo sapiens	IC50	=	970.0	nM	PMID[574286]
NPT466	Cell Line	U-937	Homo sapiens	IC50	=	1200.0	nM	PMID[574286]
NPT83	Cell Line	MCF7	Homo sapiens	IC50	=	2700.0	nM	PMID[574286]
NPT4246	Cell Line	LS174T	Homo sapiens	IC50	=	8900.0	nM	PMID[574286]
NPT81	Cell Line	A549	Homo sapiens	IC50	=	7300.0	nM	PMID[574286]
NPT927	Cell Line	PBMC	Homo sapiens	IC50	=	5000.0	nM	PMID[574286]
NPT82	Cell Line	MDA-MB-231	Homo sapiens	IC50	=	6500.0	nM	PMID[574288]
NPT81	Cell Line	A549	Homo sapiens	IC50	=	6500.0	nM	PMID[574288]
NPT165	Cell Line	HeLa	Homo sapiens	IC50	=	6500.0	nM	PMID[574288]
NPT83	Cell Line	MCF7	Homo sapiens	IC50	=	6500.0	nM	PMID[574288]
NPT2615	Cell Line	HEK-293T	Homo sapiens	IC50	=	1520.0	nM	PMID[574288]
NPT165	Cell Line	HeLa	Homo sapiens	IC50	=	7840.0	nM	PMID[574289]
NPT83	Cell Line	MCF7	Homo sapiens	IC50	=	9550.0	nM	PMID[574289]
NPT81	Cell Line	A549	Homo sapiens	IC50	=	6130.0	nM	PMID[574289]
NPT397	Cell Line	NCI-H460	Homo sapiens	IC50	=	5040.0	nM	PMID[574289]
NPT2341	Cell Line	NCI-H1975	Homo sapiens	IC50	=	4280.0	nM	PMID[574289]
NPT285	Individual Protein	Epidermal growth factor receptor erbB1	Homo sapiens	Inhibition	=	50.9	%	PMID[574289]
NPT285	Individual Protein	Epidermal growth factor receptor erbB1	Homo sapiens	IC50	=	139.2	nM	PMID[574289]
NPT148	Cell Line	HCT-15	Homo sapiens	IC50	=	860.0	nM	PMID[574290]
NPT3140	Cell Line	MGC-803	Homo sapiens	IC50	=	1510.0	nM	PMID[574290]
NPT111	Cell Line	K562	Homo sapiens	IC50	=	1020.0	nM	PMID[574290]
NPT1385	Individual Protein	Histone-lysine N-methyltransferase SETD7	Homo sapiens	Inhibition	=	90.0	%	PMID[574291]
NPT1385	Individual Protein	Histone-lysine N-methyltransferase SETD7	Homo sapiens	Inhibition	=	72.0	%	PMID[574291]
NPT1385	Individual Protein	Histone-lysine N-methyltransferase SETD7	Homo sapiens	Inhibition	=	50.0	%	PMID[574291]
NPT1385	Individual Protein	Histone-lysine N-methyltransferase SETD7	Homo sapiens	IC50	=	21620.0	nM	PMID[574291]
NPT65	Cell Line	HepG2	Homo sapiens	IC50	=	2920.0	nM	PMID[574294]
NPT139	Cell Line	HT-29	Homo sapiens	IC50	=	2800.0	nM	PMID[574294]
NPT393	Cell Line	HCT-116	Homo sapiens	IC50	=	2470.0	nM	PMID[574294]
NPT82	Cell Line	MDA-MB-231	Homo sapiens	IC50	=	2770.0	nM	PMID[574294]
NPT81	Cell Line	A549	Homo sapiens	IC50	=	10250.0	nM	PMID[574294]
NPT2615	Cell Line	HEK-293T	Homo sapiens	CC50	=	7000.0	nM	PMID[574294]
NPT83	Cell Line	MCF7	Homo sapiens	IC50	=	5400.0	nM	PMID[574294]
NPT83	Cell Line	MCF7	Homo sapiens	IC50	=	23410.0	nM	PMID[574294]
NPT111	Cell Line	K562	Homo sapiens	IC50	=	20290.0	nM	PMID[574294]
NPT111	Cell Line	K562	Homo sapiens	IC50	=	120540.0	nM	PMID[574294]
NPT139	Cell Line	HT-29	Homo sapiens	Activity	=	52.4	%	PMID[574294]
NPT139	Cell Line	HT-29	Homo sapiens	Activity	=	19.5	%	PMID[574294]
NPT139	Cell Line	HT-29	Homo sapiens	Activity	=	28.1	%	PMID[574294]
NPT139	Cell Line	HT-29	Homo sapiens	Activity	=	50.02	%	PMID[574294]
NPT139	Cell Line	HT-29	Homo sapiens	Activity	=	22.9	%	PMID[574294]
NPT139	Cell Line	HT-29	Homo sapiens	Activity	=	27.08	%	PMID[574294]
NPT139	Cell Line	HT-29	Homo sapiens	Activity	=	32.11	%	PMID[574294]
NPT139	Cell Line	HT-29	Homo sapiens	Activity	=	24.51	%	PMID[574294]
NPT139	Cell Line	HT-29	Homo sapiens	Activity	=	43.57	%	PMID[574294]
NPT139	Cell Line	HT-29	Homo sapiens	Activity	=	91.0	%	PMID[574294]
NPT139	Cell Line	HT-29	Homo sapiens	Activity	=	7.1	%	PMID[574294]
NPT139	Cell Line	HT-29	Homo sapiens	Activity	=	0.7	%	PMID[574294]
NPT139	Cell Line	HT-29	Homo sapiens	Activity	=	1.2	%	PMID[574294]
NPT139	Cell Line	HT-29	Homo sapiens	Activity	=	86.95	%	PMID[574294]
NPT139	Cell Line	HT-29	Homo sapiens	Activity	=	11.9	%	PMID[574294]
NPT139	Cell Line	HT-29	Homo sapiens	Activity	=	0.4	%	PMID[574294]
NPT139	Cell Line	HT-29	Homo sapiens	Activity	=	76.7	%	PMID[574294]
NPT139	Cell Line	HT-29	Homo sapiens	Activity	=	3.2	%	PMID[574294]
NPT139	Cell Line	HT-29	Homo sapiens	Activity	=	0.6	%	PMID[574294]
NPT2182	Cell Line	Mo	Homo sapiens	IC50	=	819.71	nM	DOI[10.6019/CHEMBL1201861]
NPT2	Others	Unspecified		IC50	>	1000000.0	nM	PMID[574255]
NPT2	Others	Unspecified		Selectivity ratio	=	2.0	n.a.	PMID[574256]
NPT16	Organism	Staphylococcus aureus	Staphylococcus aureus	MIC	>	200.0	ug.mL-1	PMID[574257]
NPT1390	Organism	Kocuria rosea	Kocuria rosea	MIC	=	200.0	ug.mL-1	PMID[574257]
NPT729	Organism	Micrococcus luteus	Micrococcus luteus	MIC	=	100.0	ug.mL-1	PMID[574257]
NPT79	Organism	Bacillus subtilis	Bacillus subtilis	MIC	>	200.0	ug.mL-1	PMID[574257]
NPT1533	Organism	Saccharomyces	Saccharomyces	MIC	=	3.1	ug.mL-1	PMID[574257]
NPT329	Organism	Trichophyton rubrum	Trichophyton rubrum	MIC	=	25.0	ug.mL-1	PMID[574257]
NPT330	Organism	Trichophyton mentagrophytes	Trichophyton mentagrophytes	MIC	=	25.0	ug.mL-1	PMID[574257]
NPT4799	Organism	Trichophyton tonsurans var. sulfureum	Trichophyton tonsurans var. sulfureum	MIC	=	25.0	ug.mL-1	PMID[574257]
NPT327	Organism	Microsporum gypseum	Microsporum gypseum	MIC	=	12.5	ug.mL-1	PMID[574257]
NPT328	Organism	Epidermophyton floccosum	Epidermophyton floccosum	MIC	=	6.2	ug.mL-1	PMID[574257]
NPT16	Organism	Staphylococcus aureus	Staphylococcus aureus	Ratio	<=	2.0	n.a.	PMID[574258]
NPT175	Organism	Enterococcus faecalis	Enterococcus faecalis	MBC	=	50.0	ug ml-1	PMID[574258]
NPT175	Organism	Enterococcus faecalis	Enterococcus faecalis	MIC	=	25.0	ug.mL-1	PMID[574258]
NPT1531	Organism	Enterococcus faecium	Enterococcus faecium	MBC	=	50.0	ug ml-1	PMID[574258]
NPT1531	Organism	Enterococcus faecium	Enterococcus faecium	MIC	=	50.0	ug.mL-1	PMID[574258]
NPT175	Organism	Enterococcus faecalis	Enterococcus faecalis	MIC	=	50.0	ug.mL-1	PMID[574258]
NPT16	Organism	Staphylococcus aureus	Staphylococcus aureus	MBC	=	12.5	ug ml-1	PMID[574258]
NPT16	Organism	Staphylococcus aureus	Staphylococcus aureus	MIC	=	6.25	ug.mL-1	PMID[574258]
NPT175	Organism	Enterococcus faecalis	Enterococcus faecalis	Ratio	<=	2.0	n.a.	PMID[574258]
NPT1531	Organism	Enterococcus faecium	Enterococcus faecium	Ratio	<=	2.0	n.a.	PMID[574258]
NPT20529	NON-MOLECULAR	NON-PROTEIN TARGET	n.a.	IC50	=	18100.0	nM	PMID[574260]
NPT2	Others	Unspecified		Inhibition	=	31.5	%	PMID[574261]
NPT2	Others	Unspecified		Inhibition	=	15.8	%	PMID[574261]
NPT2	Others	Unspecified		Inhibition	=	0.0	%	PMID[574261]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Inhibition	=	13.7	%	PMID[574262]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Inhibition	=	22.3	%	PMID[574262]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	22.0	%	PMID[574262]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	20.6	%	PMID[574262]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	26.7	%	PMID[574263]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	23.2	%	PMID[574263]
NPT20529	NON-MOLECULAR	NON-PROTEIN TARGET	n.a.	IC50	=	670.0	nM	PMID[574265]
NPT20529	NON-MOLECULAR	NON-PROTEIN TARGET	n.a.	IC50	=	1410.0	nM	PMID[574265]
NPT93	Individual Protein	Survival motor neuron protein	Homo sapiens	Potency	=	5623.4	nM	PMID[574266]
NPT94	Individual Protein	Aldehyde dehydrogenase 1A1	Homo sapiens	Potency	=	15848.9	nM	PMID[574266]
NPT27	Others	Unspecified		IC50	=	1300.0	nM	PMID[574267]
NPT35	Others	n.a.		LogP	=	0.92	n.a.	PMID[574267]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	8.3	%	PMID[574267]
NPT533	Protein-Protein Interaction	Runt-related transcription factor 1/Core-binding factor subunit beta	Homo sapiens	Potency	n.a.	68.4	nM	PMID[574266]
NPT533	Protein-Protein Interaction	Runt-related transcription factor 1/Core-binding factor subunit beta	Homo sapiens	Potency	n.a.	1122.0	nM	PMID[574266]
NPT2	Others	Unspecified		Ki	=	58800.0	nM	PMID[574269]
NPT2	Others	Unspecified		Kic	=	21.4	uM	PMID[574269]
NPT2	Others	Unspecified		IC50	=	53800.0	nM	PMID[574269]
NPT317	Uncleic Acid	Nucleic Acid		Activity	=	0.0	%	PMID[574270]
NPT474	Organism	Plasmodium berghei	Plasmodium berghei	IC50	=	1370.0	nM	PMID[574271]
NPT6	Organism	Plasmodium falciparum	Plasmodium falciparum	IC50	>	5000.0	nM	PMID[574271]
NPT533	Protein-Protein Interaction	Runt-related transcription factor 1/Core-binding factor subunit beta	Homo sapiens	Potency	n.a.	0.0543	nM	PMID[574266]
NPT67	Individual Protein	Cholinesterase	Equus caballus	Inhibition	=	3.58	%	PMID[574272]
NPT1499	Organism	Erwinia amylovora	Erwinia amylovora	MIC	=	100000.0	nM	PMID[574273]
NPT1780	Organism	Davidiella tassiana	Davidiella tassiana	IZ	=	9.9	mm	PMID[574274]
NPT1780	Organism	Davidiella tassiana	Davidiella tassiana	IZ	=	13.4	mm	PMID[574274]
NPT1780	Organism	Davidiella tassiana	Davidiella tassiana	IZ	=	14.1	mm	PMID[574274]
NPT1780	Organism	Davidiella tassiana	Davidiella tassiana	IZ	=	15.9	mm	PMID[574274]
NPT20529	NON-MOLECULAR	NON-PROTEIN TARGET	n.a.	Survival	=	47.0	%	PMID[574276]
NPT20529	NON-MOLECULAR	NON-PROTEIN TARGET	n.a.	Activity	=	37.0	%	PMID[574276]
NPT20529	NON-MOLECULAR	NON-PROTEIN TARGET	n.a.	TGI	=	63.0	%	PMID[574276]
NPT27	Others	Unspecified		IC50	=	1200.0	nM	PMID[574277]
NPT20529	NON-MOLECULAR	NON-PROTEIN TARGET	n.a.	IC50	=	40.0	nM	PMID[574278]
NPT2	Others	Unspecified		Ratio IC50	=	2.9	n.a.	PMID[574279]
NPT23095	CELL-LINE	BEAS-2B	Homo sapiens	IC50	=	5360.0	nM	PMID[574279]
NPT2	Others	Unspecified		Ratio IC50	=	4.5	n.a.	PMID[574279]
NPT2	Others	Unspecified		Ratio IC50	=	1.5	n.a.	PMID[574279]
NPT2	Others	Unspecified		IC50	=	1250.0	nM	PMID[574281]
NPT2	Others	Unspecified		Ratio IC50	=	20.0	n.a.	PMID[574282]
NPT21742	CELL-LINE	L02	Homo sapiens	IC50	=	3410.0	nM	PMID[574283]
NPT2	Others	Unspecified		Ratio IC50	=	1.5	n.a.	PMID[574284]
NPT2	Others	Unspecified		Ratio IC50	=	4.5	n.a.	PMID[574284]
NPT911	Individual Protein	Dual specificity phosphatase Cdc25B	Homo sapiens	IC50	=	400.0	nM	PMID[574286]
NPT320	Protein Family	DNA topoisomerase II	Homo sapiens	IC50	=	6200.0	nM	PMID[574287]
NPT320	Protein Family	DNA topoisomerase II	Homo sapiens	IC50	=	6700.0	nM	PMID[574287]
NPT320	Protein Family	DNA topoisomerase II	Homo sapiens	IC50	=	16000.0	nM	PMID[574287]
NPT320	Protein Family	DNA topoisomerase II	Homo sapiens	IC50	=	12500.0	nM	PMID[574287]
NPT320	Protein Family	DNA topoisomerase II	Homo sapiens	IC50	=	5700.0	nM	PMID[574287]
NPT320	Protein Family	DNA topoisomerase II	Homo sapiens	IC50	=	7800.0	nM	PMID[574287]
NPT21742	CELL-LINE	L02	Homo sapiens	IC50	=	13000.0	nM	PMID[574287]
NPT21742	CELL-LINE	L02	Homo sapiens	IC50	=	6220.0	nM	PMID[574288]
NPT21742	CELL-LINE	L02	Homo sapiens	CC50	=	12200.0	nM	PMID[574289]
NPT2	Others	Unspecified		IC50	=	1250.0	nM	PMID[574290]
NPT2	Others	Unspecified		Ratio IC50	=	1.45	n.a.	PMID[574290]
NPT20555	ORGANISM	SARS-CoV-2	Severe acute respiratory syndrome coronavirus 2	IC50	>	20000.0	nM	PMID[574292]
NPT20555	ORGANISM	SARS-CoV-2	Severe acute respiratory syndrome coronavirus 2	IC50	>	19952.62	nM	PMID[574292]
NPT2	Others	Unspecified		IC50	=	15750.0	nM	PMID[574293]
NPT21742	CELL-LINE	L02	Homo sapiens	CC50	=	11770.0	nM	PMID[574294]
NPT2	Others	Unspecified		Ratio IC50	=	4.33	n.a.	PMID[574294]
NPT2	Others	Unspecified		Ratio IC50	=	5.94	n.a.	PMID[574294]
NPT2	Others	Unspecified		IC50	=	1650	nM	PMID[20403646]

☑ Note for Activity Records:
☉ The quantitative biological activities were primarily integrated from ChEMBL (Version-30) database and were also directly collected from PubMed literature. PubMed PMID was provided as the reference link for each activity record.

Chemically structural similarity: I. Similar Active Natural Products in NPASS

Top-200 similar NPs were calculated against the active-NP-set (includes 4,3285 NPs with experimentally-derived bioactivity available in NPASS)

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules. Tc lies between [0, 1] where '1' indicates the highest similarity. What is Tanimoto coefficient

● The left chart: Distribution of similarity level between NPC246693 and all remaining natural products in the NPASS database.
● The right table: Most similar natural products (Tc>=0.56 or Top200).

range	Tanimoto Coefficient
0-0.1	286
0.1-0.2	1247
0.2-0.3	3094
0.3-0.4	8254
0.4-0.5	11296
0.5-0.6	4851
0.6-0.7	9574
0.7-0.8	3665
0.8-0.85	306
0.85-0.9	89
0.9-0.95	32
0.95-1	3

Similarity Score	Similarity Level	Natural Product ID
1.0	High Similarity	NPC110609
1.0	High Similarity	NPC242358
0.952	High Similarity	NPC306765
0.9323	High Similarity	NPC471602
0.9323	High Similarity	NPC256463
0.9323	High Similarity	NPC476477
0.9323	High Similarity	NPC306835
0.9323	High Similarity	NPC111422
0.9323	High Similarity	NPC29771
0.9323	High Similarity	NPC299405
0.9323	High Similarity	NPC216312
0.9318	High Similarity	NPC305060
0.9254	High Similarity	NPC42262
0.9254	High Similarity	NPC32749
0.9254	High Similarity	NPC220496
0.9254	High Similarity	NPC147542
0.9254	High Similarity	NPC37992
0.9254	High Similarity	NPC327916
0.9254	High Similarity	NPC241349
0.9185	High Similarity	NPC257003
0.9185	High Similarity	NPC471444
0.9118	High Similarity	NPC474300
0.9062	High Similarity	NPC3224
0.9062	High Similarity	NPC1991
0.9062	High Similarity	NPC231774
0.9055	High Similarity	NPC234890
0.9055	High Similarity	NPC74507
0.9051	High Similarity	NPC476473
0.9023	High Similarity	NPC281513
0.9023	High Similarity	NPC22222
0.9008	High Similarity	NPC205992
0.9	High Similarity	NPC278928
0.8992	High Similarity	NPC471530
0.8986	High Similarity	NPC89664
0.8986	High Similarity	NPC274085
0.8986	High Similarity	NPC477409
0.896	High Similarity	NPC206778
0.896	High Similarity	NPC285829
0.8955	High Similarity	NPC272268
0.8939	High Similarity	NPC70622
0.8915	High Similarity	NPC136342
0.8915	High Similarity	NPC295202
0.8915	High Similarity	NPC49647
0.8915	High Similarity	NPC96915
0.8915	High Similarity	NPC227741
0.8906	High Similarity	NPC310540
0.8906	High Similarity	NPC68756
0.8906	High Similarity	NPC152525
0.8898	High Similarity	NPC307174
0.8897	High Similarity	NPC295339
0.8889	High Similarity	NPC245923
0.888	High Similarity	NPC232178
0.8849	High Similarity	NPC103910
0.8837	High Similarity	NPC103540
0.8837	High Similarity	NPC131799
0.8824	High Similarity	NPC61590
0.8815	High Similarity	NPC474813
0.8815	High Similarity	NPC315275
0.881	High Similarity	NPC7151
0.881	High Similarity	NPC216297
0.881	High Similarity	NPC473662
0.8797	High Similarity	NPC58685
0.8788	High Similarity	NPC136588
0.8788	High Similarity	NPC199253
0.8779	High Similarity	NPC237225
0.8779	High Similarity	NPC282923
0.8768	High Similarity	NPC187843
0.8759	High Similarity	NPC477408
0.8741	High Similarity	NPC283088
0.8731	High Similarity	NPC115458
0.8731	High Similarity	NPC314048
0.8722	High Similarity	NPC85342
0.872	High Similarity	NPC269414
0.8712	High Similarity	NPC146647
0.8712	High Similarity	NPC34414
0.8712	High Similarity	NPC99731
0.8686	High Similarity	NPC173980
0.8682	High Similarity	NPC477153
0.8682	High Similarity	NPC375356
0.8657	High Similarity	NPC309430
0.8651	High Similarity	NPC41567
0.8647	High Similarity	NPC198305
0.8647	High Similarity	NPC475741
0.8647	High Similarity	NPC55949
0.8643	High Similarity	NPC21873
0.864	High Similarity	NPC108288
0.864	High Similarity	NPC477453
0.8636	High Similarity	NPC247250
0.8636	High Similarity	NPC165257
0.8636	High Similarity	NPC767
0.8636	High Similarity	NPC48248
0.8633	High Similarity	NPC124365
0.8626	High Similarity	NPC51037
0.8623	High Similarity	NPC103337
0.8623	High Similarity	NPC114620
0.8605	High Similarity	NPC300274
0.8593	High Similarity	NPC52407
0.8592	High Similarity	NPC300540
0.8582	High Similarity	NPC29932
0.8582	High Similarity	NPC244699
0.8582	High Similarity	NPC17083
0.8571	High Similarity	NPC135524
0.856	High Similarity	NPC240163
0.855	High Similarity	NPC240744
0.855	High Similarity	NPC167055
0.854	High Similarity	NPC155211
0.8519	High Similarity	NPC477406
0.8519	High Similarity	NPC88864
0.8511	High Similarity	NPC143898
0.8507	High Similarity	NPC31799
0.85	High Similarity	NPC305845
0.85	High Similarity	NPC204045
0.8485	Intermediate Similarity	NPC472047
0.8473	Intermediate Similarity	NPC173978
0.8473	Intermediate Similarity	NPC142956
0.8467	Intermediate Similarity	NPC161632
0.8462	Intermediate Similarity	NPC136878
0.8456	Intermediate Similarity	NPC254603
0.8456	Intermediate Similarity	NPC53896
0.8456	Intermediate Similarity	NPC171968
0.8456	Intermediate Similarity	NPC193169
0.8451	Intermediate Similarity	NPC244691
0.8451	Intermediate Similarity	NPC471906
0.844	Intermediate Similarity	NPC329493
0.844	Intermediate Similarity	NPC474961
0.844	Intermediate Similarity	NPC469520
0.8435	Intermediate Similarity	NPC182921
0.8435	Intermediate Similarity	NPC474824
0.8435	Intermediate Similarity	NPC218870
0.8435	Intermediate Similarity	NPC470408
0.8433	Intermediate Similarity	NPC474546
0.8429	Intermediate Similarity	NPC315578
0.8421	Intermediate Similarity	NPC45537
0.8417	Intermediate Similarity	NPC206207
0.8413	Intermediate Similarity	NPC161304
0.8406	Intermediate Similarity	NPC141934
0.8406	Intermediate Similarity	NPC86524
0.8394	Intermediate Similarity	NPC166480
0.8394	Intermediate Similarity	NPC288089
0.8394	Intermediate Similarity	NPC50924
0.8394	Intermediate Similarity	NPC282780
0.8392	Intermediate Similarity	NPC471683
0.8392	Intermediate Similarity	NPC474630
0.8382	Intermediate Similarity	NPC17843
0.837	Intermediate Similarity	NPC31539
0.837	Intermediate Similarity	NPC117609
0.837	Intermediate Similarity	NPC147757
0.8357	Intermediate Similarity	NPC1268
0.8357	Intermediate Similarity	NPC138099
0.8357	Intermediate Similarity	NPC143438
0.8357	Intermediate Similarity	NPC242994
0.8357	Intermediate Similarity	NPC26924
0.8357	Intermediate Similarity	NPC190457
0.8346	Intermediate Similarity	NPC71610
0.8345	Intermediate Similarity	NPC147418
0.8345	Intermediate Similarity	NPC94781
0.8333	Intermediate Similarity	NPC285122
0.8322	Intermediate Similarity	NPC474861
0.8321	Intermediate Similarity	NPC213485
0.8321	Intermediate Similarity	NPC225051
0.8321	Intermediate Similarity	NPC139074
0.8321	Intermediate Similarity	NPC40524
0.831	Intermediate Similarity	NPC85310
0.831	Intermediate Similarity	NPC137649
0.8309	Intermediate Similarity	NPC205360
0.8308	Intermediate Similarity	NPC472046
0.8298	Intermediate Similarity	NPC183345
0.8298	Intermediate Similarity	NPC169452
0.8298	Intermediate Similarity	NPC181560
0.8288	Intermediate Similarity	NPC44378
0.8288	Intermediate Similarity	NPC280753
0.8288	Intermediate Similarity	NPC120171
0.8286	Intermediate Similarity	NPC13715
0.8284	Intermediate Similarity	NPC470841
0.8273	Intermediate Similarity	NPC472308
0.8273	Intermediate Similarity	NPC193358
0.8271	Intermediate Similarity	NPC472592
0.8264	Intermediate Similarity	NPC34482
0.8264	Intermediate Similarity	NPC170055
0.8261	Intermediate Similarity	NPC474394
0.8261	Intermediate Similarity	NPC287604
0.8261	Intermediate Similarity	NPC202225
0.8261	Intermediate Similarity	NPC44437
0.8261	Intermediate Similarity	NPC472262
0.8261	Intermediate Similarity	NPC12070
0.8261	Intermediate Similarity	NPC161964
0.8258	Intermediate Similarity	NPC275145
0.8258	Intermediate Similarity	NPC135062
0.8252	Intermediate Similarity	NPC471682
0.8248	Intermediate Similarity	NPC478190
0.8239	Intermediate Similarity	NPC91019
0.8239	Intermediate Similarity	NPC283292
0.8239	Intermediate Similarity	NPC106519
0.8235	Intermediate Similarity	NPC123
0.8235	Intermediate Similarity	NPC163169
0.8231	Intermediate Similarity	NPC315520
0.8227	Intermediate Similarity	NPC162939
0.8219	Intermediate Similarity	NPC112816
0.8214	Intermediate Similarity	NPC53414
0.8214	Intermediate Similarity	NPC471905

Chemically structural similarity: II. Similar Clinical/Approved Drugs

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules.

● The left chart: Distribution of similarity level between NPC246693 and all drugs/candidates.
● The right table: Most similar clinical/approved drugs (Tc>=0.56 or Top200).

range	Tanimoto Coefficient
0-0.1	265
0.1-0.2	884
0.2-0.3	1468
0.3-0.4	2631
0.4-0.5	2191
0.5-0.6	1177
0.6-0.7	463
0.7-0.8	67
0.8-0.85	2
0.85-0.9	2
0.9-0.95	0
0.95-1	0

Similarity Score	Similarity Level	Drug ID	Developmental Stage
0.8837	High Similarity	NPD1470	Approved
0.864	High Similarity	NPD405	Clinical (unspecified phase)
0.8527	High Similarity	NPD1201	Approved
0.8143	Intermediate Similarity	NPD1509	Clinical (unspecified phase)
0.7877	Intermediate Similarity	NPD3300	Phase 2
0.7832	Intermediate Similarity	NPD5406	Approved
0.7832	Intermediate Similarity	NPD2935	Discontinued
0.7832	Intermediate Similarity	NPD5404	Approved
0.7832	Intermediate Similarity	NPD5405	Approved
0.7832	Intermediate Similarity	NPD5408	Approved
0.777	Intermediate Similarity	NPD7422	Clinical (unspecified phase)
0.7703	Intermediate Similarity	NPD7390	Discontinued
0.7682	Intermediate Similarity	NPD3226	Approved
0.7655	Intermediate Similarity	NPD2346	Discontinued
0.7639	Intermediate Similarity	NPD651	Clinical (unspecified phase)
0.7606	Intermediate Similarity	NPD943	Approved
0.7556	Intermediate Similarity	NPD2932	Approved
0.75	Intermediate Similarity	NPD1878	Clinical (unspecified phase)
0.7426	Intermediate Similarity	NPD3019	Approved
0.7417	Intermediate Similarity	NPD2532	Approved
0.7417	Intermediate Similarity	NPD2534	Approved
0.7417	Intermediate Similarity	NPD2533	Approved
0.7388	Intermediate Similarity	NPD9493	Approved
0.7357	Intermediate Similarity	NPD1164	Approved
0.7353	Intermediate Similarity	NPD4196	Clinical (unspecified phase)
0.7348	Intermediate Similarity	NPD7635	Approved
0.7328	Intermediate Similarity	NPD4141	Clinical (unspecified phase)
0.7321	Intermediate Similarity	NPD8150	Discontinued
0.7308	Intermediate Similarity	NPD74	Approved
0.7308	Intermediate Similarity	NPD9266	Approved
0.7305	Intermediate Similarity	NPD2798	Approved
0.729	Intermediate Similarity	NPD4380	Phase 2
0.7289	Intermediate Similarity	NPD4955	Approved
0.7289	Intermediate Similarity	NPD36	Approved
0.7289	Intermediate Similarity	NPD5034	Approved
0.7289	Intermediate Similarity	NPD4954	Approved
0.7289	Intermediate Similarity	NPD5028	Approved
0.7289	Intermediate Similarity	NPD5026	Approved
0.7279	Intermediate Similarity	NPD2799	Discontinued
0.7279	Intermediate Similarity	NPD1510	Phase 2
0.7279	Intermediate Similarity	NPD3299	Clinical (unspecified phase)
0.7267	Intermediate Similarity	NPD6232	Discontinued
0.7261	Intermediate Similarity	NPD7819	Suspended
0.7261	Intermediate Similarity	NPD2393	Clinical (unspecified phase)
0.726	Intermediate Similarity	NPD1607	Approved
0.7251	Intermediate Similarity	NPD7879	Clinical (unspecified phase)
0.7248	Intermediate Similarity	NPD970	Clinical (unspecified phase)
0.7241	Intermediate Similarity	NPD1240	Approved
0.7239	Intermediate Similarity	NPD7473	Discontinued
0.7235	Intermediate Similarity	NPD8397	Clinical (unspecified phase)
0.7231	Intermediate Similarity	NPD9267	Approved
0.7231	Intermediate Similarity	NPD9263	Approved
0.7231	Intermediate Similarity	NPD9264	Approved
0.7229	Intermediate Similarity	NPD5030	Phase 2
0.7222	Intermediate Similarity	NPD2313	Discontinued
0.7222	Intermediate Similarity	NPD3764	Approved
0.7219	Intermediate Similarity	NPD5038	Approved
0.7219	Intermediate Similarity	NPD5037	Approved
0.7215	Intermediate Similarity	NPD5402	Approved
0.7205	Intermediate Similarity	NPD6959	Discontinued
0.7197	Intermediate Similarity	NPD6844	Discontinued
0.719	Intermediate Similarity	NPD4378	Clinical (unspecified phase)
0.7181	Intermediate Similarity	NPD2344	Approved
0.7165	Intermediate Similarity	NPD289	Clinical (unspecified phase)
0.716	Intermediate Similarity	NPD5036	Approved
0.7152	Intermediate Similarity	NPD2801	Approved
0.7143	Intermediate Similarity	NPD8313	Approved
0.7143	Intermediate Similarity	NPD8312	Approved
0.7133	Intermediate Similarity	NPD1549	Phase 2
0.7132	Intermediate Similarity	NPD1237	Approved
0.7121	Intermediate Similarity	NPD4750	Phase 3
0.7115	Intermediate Similarity	NPD5808	Clinical (unspecified phase)
0.7089	Intermediate Similarity	NPD1934	Approved
0.7071	Intermediate Similarity	NPD1547	Clinical (unspecified phase)
0.7069	Intermediate Similarity	NPD6535	Approved
0.7069	Intermediate Similarity	NPD6534	Approved
0.7067	Intermediate Similarity	NPD1550	Clinical (unspecified phase)
0.7067	Intermediate Similarity	NPD1552	Clinical (unspecified phase)
0.7055	Intermediate Similarity	NPD6663	Approved
0.7048	Intermediate Similarity	NPD5844	Phase 1
0.7045	Intermediate Similarity	NPD6831	Clinical (unspecified phase)
0.7039	Intermediate Similarity	NPD8166	Discontinued
0.7039	Intermediate Similarity	NPD3750	Approved
0.7039	Intermediate Similarity	NPD4628	Phase 3
0.7037	Intermediate Similarity	NPD5494	Approved
0.7029	Intermediate Similarity	NPD3091	Approved
0.7029	Intermediate Similarity	NPD9545	Approved
0.7024	Intermediate Similarity	NPD5027	Approved
0.7024	Intermediate Similarity	NPD5031	Approved
0.7024	Intermediate Similarity	NPD5029	Approved
0.7014	Intermediate Similarity	NPD5736	Approved
0.7011	Intermediate Similarity	NPD6214	Clinical (unspecified phase)
0.7011	Intermediate Similarity	NPD6212	Phase 3
0.7011	Intermediate Similarity	NPD6213	Phase 3
0.7	Intermediate Similarity	NPD1551	Phase 2
0.7	Intermediate Similarity	NPD3023	Approved
0.7	Intermediate Similarity	NPD2796	Approved
0.7	Intermediate Similarity	NPD8443	Clinical (unspecified phase)
0.7	Intermediate Similarity	NPD3026	Approved
0.6993	Remote Similarity	NPD3094	Phase 2
0.6993	Remote Similarity	NPD2309	Approved
0.6986	Remote Similarity	NPD1699	Clinical (unspecified phase)
0.6985	Remote Similarity	NPD5951	Approved
0.6985	Remote Similarity	NPD9281	Approved
0.6984	Remote Similarity	NPD844	Approved
0.6978	Remote Similarity	NPD3024	Approved
0.6978	Remote Similarity	NPD3025	Approved
0.6974	Remote Similarity	NPD2800	Approved
0.6974	Remote Similarity	NPD7421	Clinical (unspecified phase)
0.697	Remote Similarity	NPD9265	Clinical (unspecified phase)
0.6966	Remote Similarity	NPD6777	Approved
0.6966	Remote Similarity	NPD6779	Approved
0.6966	Remote Similarity	NPD6781	Approved
0.6966	Remote Similarity	NPD6776	Approved
0.6966	Remote Similarity	NPD6778	Approved
0.6966	Remote Similarity	NPD6782	Approved
0.6966	Remote Similarity	NPD6780	Approved
0.6959	Remote Similarity	NPD447	Suspended
0.6957	Remote Similarity	NPD3882	Suspended
0.6954	Remote Similarity	NPD2343	Clinical (unspecified phase)
0.6954	Remote Similarity	NPD1471	Phase 3
0.695	Remote Similarity	NPD3092	Approved
0.6949	Remote Similarity	NPD7700	Phase 2
0.6949	Remote Similarity	NPD7699	Phase 2
0.6944	Remote Similarity	NPD6007	Clinical (unspecified phase)
0.6929	Remote Similarity	NPD288	Approved
0.6929	Remote Similarity	NPD4626	Approved
0.6928	Remote Similarity	NPD3400	Discontinued
0.6928	Remote Similarity	NPD7003	Approved
0.6928	Remote Similarity	NPD6398	Clinical (unspecified phase)
0.6923	Remote Similarity	NPD6273	Approved
0.6923	Remote Similarity	NPD1876	Approved
0.6923	Remote Similarity	NPD9261	Approved
0.6923	Remote Similarity	NPD6559	Discontinued
0.6917	Remote Similarity	NPD2182	Approved
0.6914	Remote Similarity	NPD7075	Discontinued
0.6914	Remote Similarity	NPD4381	Clinical (unspecified phase)
0.6901	Remote Similarity	NPD9717	Approved
0.6886	Remote Similarity	NPD3818	Discontinued
0.6875	Remote Similarity	NPD1203	Approved
0.6871	Remote Similarity	NPD411	Approved
0.6867	Remote Similarity	NPD6167	Clinical (unspecified phase)
0.6867	Remote Similarity	NPD6166	Phase 2
0.6867	Remote Similarity	NPD6168	Clinical (unspecified phase)
0.6859	Remote Similarity	NPD7410	Clinical (unspecified phase)
0.6857	Remote Similarity	NPD1651	Approved
0.6852	Remote Similarity	NPD7768	Phase 2
0.6851	Remote Similarity	NPD7435	Discontinued
0.6851	Remote Similarity	NPD7698	Approved
0.6851	Remote Similarity	NPD7697	Approved
0.6851	Remote Similarity	NPD7696	Phase 3
0.6849	Remote Similarity	NPD6832	Phase 2
0.6848	Remote Similarity	NPD5711	Approved
0.6848	Remote Similarity	NPD5710	Approved
0.6846	Remote Similarity	NPD230	Phase 1
0.6846	Remote Similarity	NPD1899	Clinical (unspecified phase)
0.6842	Remote Similarity	NPD5035	Approved
0.6842	Remote Similarity	NPD2342	Discontinued
0.6832	Remote Similarity	NPD7096	Clinical (unspecified phase)
0.6824	Remote Similarity	NPD5039	Approved
0.6824	Remote Similarity	NPD520	Approved
0.6821	Remote Similarity	NPD8434	Phase 2
0.6815	Remote Similarity	NPD2181	Clinical (unspecified phase)
0.6813	Remote Similarity	NPD7411	Suspended
0.6813	Remote Similarity	NPD7870	Phase 2
0.6813	Remote Similarity	NPD7871	Phase 2
0.6809	Remote Similarity	NPD7163	Clinical (unspecified phase)
0.6809	Remote Similarity	NPD3412	Clinical (unspecified phase)
0.6809	Remote Similarity	NPD3095	Discontinued
0.6806	Remote Similarity	NPD1283	Approved
0.68	Remote Similarity	NPD6651	Approved
0.6796	Remote Similarity	NPD6823	Phase 2
0.6795	Remote Similarity	NPD1511	Approved
0.6792	Remote Similarity	NPD2651	Approved
0.6792	Remote Similarity	NPD2649	Approved
0.6786	Remote Similarity	NPD3751	Discontinued
0.6783	Remote Similarity	NPD3972	Approved
0.6783	Remote Similarity	NPD4878	Approved
0.6783	Remote Similarity	NPD9269	Phase 2
0.6774	Remote Similarity	NPD6190	Approved
0.6772	Remote Similarity	NPD5403	Approved
0.677	Remote Similarity	NPD6801	Discontinued
0.6765	Remote Similarity	NPD1609	Clinical (unspecified phase)
0.6761	Remote Similarity	NPD3496	Discontinued
0.675	Remote Similarity	NPD6599	Discontinued
0.6743	Remote Similarity	NPD6836	Approved
0.6742	Remote Similarity	NPD164	Approved
0.6739	Remote Similarity	NPD497	Approved
0.6738	Remote Similarity	NPD5691	Approved
0.6738	Remote Similarity	NPD9268	Approved
0.6736	Remote Similarity	NPD1755	Approved
0.6712	Remote Similarity	NPD6917	Clinical (unspecified phase)
0.6711	Remote Similarity	NPD3748	Approved
0.6709	Remote Similarity	NPD1512	Approved
0.6707	Remote Similarity	NPD3749	Approved
0.6706	Remote Similarity	NPD7074	Phase 3
0.6706	Remote Similarity	NPD4956	Approved
0.6703	Remote Similarity	NPD7701	Phase 2
0.6693	Remote Similarity	NPD845	Approved
0.6692	Remote Similarity	NPD3020	Approved

Bioactivity similarity: Similar Natural Products in NPASS

Bioactivity similarity was calculated based on bioactivity descriptors of compounds. The bioactivity descriptors were calculated by a recently developed AI algorithm Chemical Checker (CC) [Nature Biotechnology, 38:1087–1096, 2020; Nature Communications, 12:3932, 2021], which evaluated bioactivity similarities at five levels:
☉ A: chemistry similarity;
☉ B: biological targets similarity;
☉ C: networks similarity;
☉ D: cell-based bioactivity similarity;
☉ E: similarity based on clinical data.

Those 5 categories of CC bioactivity descriptors were calculated and then subjected to manifold projection using UMAP algorithm, to project all NPs on a 2-Dimensional space. The current NP was highlighted with a small circle in the 2-D map. Below figures: left-to-right, A-to-E.

A: chemistry similarity

B: biological targets similarity

C: networks similarity

D: cell-based bioactivity similarity

E: similarity based on clinical data