Component: Phellodendron amurense 黄柏粉


Description of the Component

Component ID
TCMH950
Latin Name
Phellodendron amurense
English Name
Amur corktree
Chinese Pinyin Name
Huang Bai Fen
中文名
黄柏粉
TCM Properties
TCM Meridians
Therapeutic Class English
Therapeutic Class Chinese
Functions
Toxicity
NA
Geo-authentic habitats (道地产区)
NA
Reference
CFDA
Barcode ID
ITSAM1586-14
Barcode Source
BOLDSYSTEMS

TCM Prescriptions with the Component

Prescription ID Prescription English Name Prescription Chinese Name
TCMFx6938 Zheng Lu Pills 正露丸

Targeted Human Proteins by the Ingredient of Component

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT1 EHMT2 Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 Transferase Q96KQ7
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT11 HIF1A Hypoxia-inducible factor 1 alpha Transcription factor Q16665
TCMT125 GBA Beta-glucocerebrosidase Hydrolase P04062
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT132 BCHE Butyrylcholinesterase Hydrolase P06276
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT143 CA3 Carbonic anhydrase III Lyase P07451
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT160 HTR7 Serotonin 7 (5-HT7) receptor GPCR P34969
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT17 POLB DNA polymerase beta Transferase P06746
TCMT176 SOAT1 Acyl coenzyme A:cholesterol acyltransferase 1 Transferase P35610
TCMT18 GAA Lysosomal alpha-glucosidase Hydrolase P10253
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT207 BACE1 Beta-secretase 1 Protease P56817
TCMT214 MGLL Monoglyceride lipase Unclassified Q99685
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT225 CA13 Carbonic anhydrase XIII Lyase Q8N1Q1
TCMT232 ABCB1 P-glycoprotein 1 Transporter P08183
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT276 SLCO2B1 Solute carrier organic anion transporter family member 2B1 Transporter O94956
TCMT277 SLCO1B3 Solute carrier organic anion transporter family member 1B3 Transporter Q9NPD5
TCMT278 SLCO1B1 Solute carrier organic anion transporter family member 1B1 Transporter Q9Y6L6
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT281 DPP4 Dipeptidyl peptidase IV Unclassified P27487
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT307 KCNH2 HERG Ion channel Q12809
TCMT309 SLC22A2 Solute carrier family 22 member 2 Transporter O15244
TCMT31 CYP2C19 Cytochrome P450 2C19 Oxidoreductase P33261
TCMT310 SLC47A2 Multidrug and toxin extrusion protein 2 Transporter Q86VL8
TCMT311 SLC47A1 Multidrug and toxin extrusion protein 1 Transporter Q96FL8
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT332 AOC3 Amine oxidase, copper containing Oxidoreductase Q16853
TCMT336 IDO1 Indoleamine 2,3-dioxygenase Oxidoreductase P14902
TCMT34 CYP2D6 Cytochrome P450 2D6 Oxidoreductase P10635
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT36 HTR1A Serotonin 1a (5-HT1a) receptor GPCR P08908
TCMT37 HTR2A Serotonin 2a (5-HT2a) receptor GPCR P28223
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT41 IDH1 Isocitrate dehydrogenase [NADP] cytoplasmic Oxidoreductase O75874
TCMT42 KMT2A Histone-lysine N-methyltransferase MLL Transferase Q03164
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT6 NFKB1 Nuclear factor NF-kappa-B p105 subunit Transcription factor P19838
TCMT615 SENP8 Sentrin-specific protease 8 Protease Q96LD8
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT637 SIRT3 NAD-dependent deacetylase sirtuin 3 Hydrolase Q9NTG7
TCMT638 SIRT2 NAD-dependent deacetylase sirtuin 2 Hydrolase Q8IXJ6
TCMT64 PPARD Peroxisome proliferator-activated receptor delta Nuclear receptor Q03181
TCMT67 PPARG Peroxisome proliferator-activated receptor gamma Nuclear receptor P37231
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT80 MAPK1 MAP kinase ERK2 Kinase P28482
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372


Targeted Pathogenic Microbes by the Ingredient of Component

Target ID Target Name
TCMT1104 Sortase
TCMT1109 Reverse transcriptase
TCMT1112 Quinolone resistance protein norA
TCMT1154 Sortase
TCMT1218 Staphylococcus aureus
TCMT1226 Klebsiella pneumoniae
TCMT1230 Human herpesvirus 5
TCMT1232 Pseudomonas aeruginosa
TCMT1236 Mycobacterium bovis
TCMT1246 Escherichia coli
TCMT1251 Candida albicans
TCMT1255 Human immunodeficiency virus 1
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1305 Salmonella enteritidis
TCMT1318 Human T-lymphotropic virus 1
TCMT1346 Helicobacter pylori
TCMT1353 Plasmodium yoelii
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1385 Candida shehatae
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1460 Mycobacterium intracellulare
TCMT1463 Mycobacterium tuberculosis
TCMT1465 Entamoeba histolytica

Ingredient Structrues

Ingredient ID: TCMC934
Formula: C20H19NO4

Ingredient ID: TCMC897
Formula: C16H18O9

Ingredient ID: TCMC865
Formula: C14H8N2O

Ingredient ID: TCMC858
Formula: C20H21NO4

Ingredient ID: TCMC801
Formula: C29H50O

Ingredient ID: TCMC785
Formula: C20H18NO4.ClH

Ingredient ID: TCMC784
Formula: C20H18NO4

Ingredient ID: TCMC315
Formula: C21H25NO4

Ingredient ID: TCMC313
Formula: C20H23NO4

Ingredient ID: TCMC2811
Formula: C19H15NO4

Ingredient ID: TCMC2442
Formula: C13H11NO3

Ingredient ID: TCMC2402
Formula: C15H14O2

Ingredient ID: TCMC2383
Formula: C20H23NO4

Ingredient ID: TCMC2378
Formula: C19H15NO4.ClH

Ingredient ID: TCMC2198
Formula: C37H40N2O6

Ingredient ID: TCMC2191
Formula: C14H12O3

Ingredient ID: TCMC2151
Formula: C20H23NO4

Ingredient ID: TCMC2150
Formula: C21H25NO4

Ingredient ID: TCMC2146
Formula: C20H21NO4

Ingredient ID: TCMC2086
Formula: C14H13NO4

Ingredient ID: TCMC2030
Formula: C18H13N3O

Ingredient ID: TCMC1871
Formula: C6H6O

Ingredient ID: TCMC1869
Formula: C8H11N

Ingredient ID: TCMC1866
Formula: C17H16O5

Ingredient ID: TCMC1831
Formula: C21H22NO4

Ingredient ID: TCMC1828
Formula: C21H22NO4.ClH

Ingredient ID: TCMC1788
Formula: C18H34O2

Ingredient ID: TCMC1771
Formula: C26H30O7

Ingredient ID: TCMC1761
Formula: C10H9NO3

Ingredient ID: TCMC1659
Formula: C20H19NO5

Ingredient ID: TCMC1636
Formula: C20H18NO4

Ingredient ID: TCMC1622
Formula: C19H17N3O

Ingredient ID: TCMC1621
Formula: C20H21NO4

Ingredient ID: TCMC1586
Formula: C17H20N2O

Ingredient ID: TCMC1491
Formula: C26H30O8

Ingredient ID: TCMC1424
Formula: C20H19NO4

Ingredient ID: TCMC1417
Formula: C8H8O3

Ingredient ID: TCMC1389
Formula: C10H12O2

Ingredient ID: TCMC1342
Formula: C21H25NO4.ClH

Ingredient ID: TCMC1210
Formula: C13H11NO3

Ingredient ID: TCMC1173
Formula: C10H10O4

Ingredient ID: TCMC1145
Formula: C11H12O4

Ingredient ID: TCMC1131
Formula: C9H6O4

Properties

Ingredient ID Formulae Name MW AlogP MlogP XlogP # HBA # HBD PSA # Rotatable Bond # Ring # Heacy Atom Lipinski RO5 Violation
TCMC313 C20H23NO4 2,3,10-Trimethoxy-6,8,13,13A-Tetrahydro-5H-Isoquinolino[2,1-B]Isoquinolin-9-Ol 341.16 -0.3117 3.11 2.029 1 1 51.16 7 4 25 0
TCMC315 C21H25NO4 2,3,9,10-Tetramethoxy-6,8,13,13A-Tetrahydro-5H-Isoquinolino[2,1-B]Isoquinoline 355.18 0.0968 3.22 2.548 1 0 40.16 8 4 26 0
TCMC784 C20H18NO4 Berberine 336.12 -1.583 3.11 2.896 0 0 40.8 4 5 25 0
TCMC785 C20H18NO4.ClH Berberine Chloride 336.12 -1.583 3.11 2.896 0 0 40.8 4 5 25 0
TCMC801 C29H50O Beta-Sitosterol 414.39 1.3 4.54 11.595 1 1 20.23 13 4 30 1
TCMC858 C20H21NO4 Canadine 339.15 -0.1023 3.11 2.475 1 0 40.16 4 5 25 0
TCMC865 C14H8N2O Canthin-6-One 220.06 -0.2737 2.67 2.809 3 0 34.89 0 4 17 0
TCMC897 C16H18O9 Chlorogenic Acid 354.1 -2.1962 2.23 -0.447 7 6 164.75 11 2 25 1
TCMC934 C20H19NO4 Columbamine 338.14 -1.7924 3.11 2.45 0 1 51.8 7 4 25 0
TCMC1131 C9H6O4 Esculetin 178.03 -0.6506 2.01 0.998 1 2 66.76 2 2 13 0
TCMC1145 C11H12O4 Ethyl Caffeate 208.07 -0.2979 2.23 1.885 2 2 66.76 7 1 15 0
TCMC1173 C10H10O4 Ferulic Acid 194.06 -0.3908 2.12 1.231 2 2 66.76 6 1 14 0
TCMC1210 C13H11NO3 Gamma-Fagarine 229.07 -0.2577 2.45 2.068 1 0 44.49 4 3 17 0
TCMC1342 C21H25NO4.ClH Hydron;2,3,9,10-Tetramethoxy-6,8,13,13A-Tetrahydro-5H-Isoquinolino[2,1-B]Isoquinoline;Chloride 355.18 0.0968 3.22 2.548 1 0 40.16 8 4 26 0
TCMC1389 C10H12O2 Isoeugenol 164.08 0.3952 2.34 2.805 0 1 29.46 5 1 12 0
TCMC1417 C8H8O3 Isovanillin 152.05 -0.7045 2.01 1.04 1 1 46.53 4 1 11 0
TCMC1424 C20H19NO4 Jatrorrhizine 338.14 -1.5606 3.11 1.039 2 1 49.2 6 4 25 0
TCMC1491 C26H30O8 Limonin 470.19 -0.4484 3.44 1.644 7 0 104.57 5 7 34 0
TCMC1586 C17H20N2O Michler's Ketone 268.16 0.1718 3 3.609 3 0 23.55 8 2 20 0
TCMC1621 C20H21NO4 339.15 -0.1023 3.11 2.475 1 0 40.16 4 5 25 0
TCMC1622 C19H17N3O 303.14 -0.5403 3.11 3.89 4 1 39.34 1 5 23 0
TCMC1636 C20H18NO4 336.12 -1.583 3.11 2.896 0 0 40.8 4 5 25 0
TCMC1659 C20H19NO5 353.13 -0.4401 3 1.86 2 0 57.23 1 5 26 0
TCMC1761 C10H9NO3 Noroxyhydrastinine 191.06 -0.3413 2.12 1.117 2 1 51.05 1 3 14 0
TCMC1771 C26H30O7 Obacunone 454.2 0.7128 3.55 2.69 6 0 95.34 6 6 33 0
TCMC1788 C18H34O2 Oleic Acid 282.26 -2.3427 3.22 8.192 2 1 37.3 17 0 20 2
TCMC1828 C21H22NO4.ClH Palmatine Chloride 352.15 -1.3839 3.22 2.969 0 0 40.8 8 4 26 0
TCMC1831 C21H22NO4 Palmitine 352.15 -1.3839 3.22 2.969 0 0 40.8 8 4 26 0
TCMC1866 C17H16O5 Phellopterin 300.1 1.4778 2.78 2.447 1 0 57.9 7 3 22 0
TCMC1869 C8H11N Phenethylamine 121.09 -0.4827 2.23 3.122 1 1 26.02 3 1 9 0
TCMC1871 C6H6O Phenol 94.04 -0.4603 2.01 2.044 0 1 20.23 1 1 7 0
TCMC2030 C18H13N3O Rutaecarpine 287.11 -0.7533 3 3.951 4 1 48.46 0 5 22 0
TCMC2086 C14H13NO4 Skimmianine 259.08 -0.3095 2.45 1.624 1 0 53.72 6 3 19 0
TCMC2146 C20H21NO4 Tetrahydroberberine 339.15 -0.1023 3.11 2.475 1 0 40.16 4 5 25 0
TCMC2150 C21H25NO4 Tetrahydropalmatine 355.18 0.0968 3.22 2.548 1 0 40.16 8 4 26 0
TCMC2151 C20H23NO4 Tetrahydropalmatrubine 341.16 -0.3117 3.11 2.029 1 1 51.16 7 4 25 0
TCMC2191 C14H12O3 Trioxsalen 228.08 1.6438 2.67 2.805 1 0 39.44 3 3 17 0
TCMC2198 C37H40N2O6 Tubocurarine 609.3 -1.8978 4.65 4.869 1 2 80.62 9 6 45 0
TCMC2378 C19H15NO4.ClH Thalifendine 321.1 -0.1514 3 2.164 3 0 48 2 5 24 0
TCMC2383 C20H23NO4 Magnoflorine 342.17 -1.9843 3.11 1.008 0 2 58.92 8 4 25 0
TCMC2402 C15H14O2 4-[(Z)-2-(3-Methoxyphenyl)Ethenyl]Phenol 226.1 -0.0443 2.89 5.129 0 1 29.46 5 2 17 1
TCMC2442 C13H11NO3 Pteleine 229.07 -0.2577 2.45 2.068 1 0 44.49 4 3 17 0
TCMC2811 C19H15NO4 Thalidendine 322.11 -0.1281 3 2.096 2 1 30.93 2 5 24 0

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1. General Information of the Component  
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3. Putative Targets  
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5. Ingredient Data & Chemical Structure Information (Properties, InChI, InChIkey, SMILES, etc.)