Component: Clerodendrum trichotomum 臭梧桐


Description of the Component

Component ID
TCMH270
Latin Name
Clerodendrum trichotomum
English Name
Harlequin glorybower
Chinese Pinyin Name
Chou Wu Tong
中文名
臭梧桐
TCM Properties
Pungent, bitter, sweet,cool
TCM Meridians
Therapeutic Class English
For dispelling wind-dampness
Therapeutic Class Chinese
祛风湿
Functions
dispel wind and dampness
Toxicity
NA
Geo-authentic habitats (道地产区)
NA
Reference
CFDA
Barcode ID
GBVG2859-11, GBVG2857-11
Barcode Source
BOLDSYSTEMS

TCM Prescriptions with the Component

Prescription ID Prescription English Name Prescription Chinese Name
TCMFx3503 Feng Shi Xi Tong Tablets 风湿豨桐片
TCMF4525 Jiang Ya Tablets 降压片
TCMFx5782 Xi Tong Capsules 豨桐胶囊
TCMFx5790 Xi Tong Pills 豨桐丸

Targeted Human Proteins by the Ingredient of Component

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT113 OPRD1 Delta opioid receptor GPCR P41143
TCMT116 OPRM1 Mu opioid receptor GPCR P35372
TCMT117 OPRK1 Kappa opioid receptor GPCR P41145
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT143 CA3 Carbonic anhydrase III Lyase P07451
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT160 HTR7 Serotonin 7 (5-HT7) receptor GPCR P34969
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT17 POLB DNA polymerase beta Transferase P06746
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT18 GAA Lysosomal alpha-glucosidase Hydrolase P10253
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT242 HRH3 Histamine H3 receptor GPCR Q9Y5N1
TCMT243 ADRA2C Alpha-2c adrenergic receptor GPCR P18825
TCMT244 HRH1 Histamine H1 receptor GPCR P35367
TCMT246 HRH4 Histamine H4 receptor GPCR Q9H3N8
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT281 DPP4 Dipeptidyl peptidase IV Unclassified P27487
TCMT290 CHRM5 Muscarinic acetylcholine receptor M5 GPCR P08912
TCMT291 CHRM3 Muscarinic acetylcholine receptor M3 GPCR P20309
TCMT292 CHRM1 Muscarinic acetylcholine receptor M1 GPCR P11229
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT31 CYP2C19 Cytochrome P450 2C19 Oxidoreductase P33261
TCMT311 SLC47A1 Multidrug and toxin extrusion protein 1 Transporter Q96FL8
TCMT313 HTR2B Serotonin 2b (5-HT2b) receptor GPCR P41595
TCMT314 HTR2C Serotonin 2c (5-HT2c) receptor GPCR P28335
TCMT315 HTR6 Serotonin 6 (5-HT6) receptor GPCR P50406
TCMT318 HKDC1 Putative hexokinase HKDC1 Transferase Q2TB90
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT336 IDO1 Indoleamine 2,3-dioxygenase Oxidoreductase P14902
TCMT34 CYP2D6 Cytochrome P450 2D6 Oxidoreductase P10635
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT36 HTR1A Serotonin 1a (5-HT1a) receptor GPCR P08908
TCMT37 HTR2A Serotonin 2a (5-HT2a) receptor GPCR P28223
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT41 IDH1 Isocitrate dehydrogenase [NADP] cytoplasmic Oxidoreductase O75874
TCMT42 KMT2A Histone-lysine N-methyltransferase MLL Transferase Q03164
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT551 CHRM4 Muscarinic acetylcholine receptor M4 GPCR P08173
TCMT559 ADRB2 Beta-2 adrenergic receptor GPCR P07550
TCMT588 DAO D-amino-acid oxidase Oxidoreductase P14920
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT598 TOP1 DNA topoisomerase I Isomerase P11387
TCMT633 SLC6A4 Serotonin transporter Transporter P31645
TCMT634 SLC6A2 Norepinephrine transporter Transporter P23975
TCMT635 SLC6A3 Dopamine transporter Transporter Q01959
TCMT64 PPARD Peroxisome proliferator-activated receptor delta Nuclear receptor Q03181
TCMT642 ADRA1D Alpha-1d adrenergic receptor GPCR P25100
TCMT643 ADRA1A Alpha-1a adrenergic receptor GPCR P35348
TCMT644 HTR3A Serotonin 3a (5-HT3a) receptor Ion channel P46098
TCMT645 HTR1E Serotonin 1e (5-HT1e) receptor GPCR P28566
TCMT646 HTR5A Serotonin 5a (5-HT5a) receptor GPCR P47898
TCMT647 ADRA2B Alpha-2b adrenergic receptor GPCR P18089
TCMT648 DRD4 Dopamine D4 receptor GPCR P21917
TCMT649 DRD5 Dopamine D5 receptor GPCR P21918
TCMT650 ADRA1B Alpha-1b adrenergic receptor GPCR P35368
TCMT651 DRD3 Dopamine D3 receptor GPCR P35462
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT80 MAPK1 MAP kinase ERK2 Kinase P28482
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712


Targeted Pathogenic Microbes by the Ingredient of Component

Target ID Target Name
TCMT1104 Sortase
TCMT1170 Enterobacter cloacae
TCMT1214 Enterococcus faecium
TCMT1218 Staphylococcus aureus
TCMT1223 Staphylococcus epidermidis
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1246 Escherichia coli
TCMT1251 Candida albicans
TCMT1294 Human parainfluenza virus 3
TCMT1310 Enterococcus hirae
TCMT1355 Rhodococcus equi
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1454 Bacillus subtilis
TCMT1458 Filobasidiella neoformans
TCMT1463 Mycobacterium tuberculosis
TCMT1465 Entamoeba histolytica

Ingredient Structrues

Ingredient ID: TCMC995
Formula: C35H60O6

Ingredient ID: TCMC848
Formula: C17H17NO3

Ingredient ID: TCMC801
Formula: C29H50O

Ingredient ID: TCMC6
Formula: C20H23NO4

Ingredient ID: TCMC553
Formula: C6H6O3

Ingredient ID: TCMC495
Formula: C7H6O2

Ingredient ID: TCMC338
Formula: C8H8O4

Ingredient ID: TCMC2642
Formula: C17H9NO3

Ingredient ID: TCMC2638
Formula: C15H22O9

Ingredient ID: TCMC2566
Formula: C10H22O

Ingredient ID: TCMC2543
Formula: C19H21NO5

Ingredient ID: TCMC2528
Formula: C18H13NO3

Ingredient ID: TCMC2506
Formula: C19H21NO4

Ingredient ID: TCMC2458
Formula: C35H58O6

Ingredient ID: TCMC2317
Formula: C19H21NO4

Ingredient ID: TCMC2223
Formula: C8H8O3

Ingredient ID: TCMC2222
Formula: C8H8O4

Ingredient ID: TCMC2209
Formula: C9H12N2O6

Ingredient ID: TCMC2119
Formula: C9H10O5

Ingredient ID: TCMC2117
Formula: C22H26O8

Ingredient ID: TCMC2107
Formula: C29H48O

Ingredient ID: TCMC1839
Formula: C7H6O3

Ingredient ID: TCMC1814
Formula: C20H17NO5

Ingredient ID: TCMC1748
Formula: C20H23NO4

Ingredient ID: TCMC1741
Formula: C6H5NO2

Ingredient ID: TCMC1582
Formula: C8H8O3

Ingredient ID: TCMC1566
Formula: C10H10O3

Ingredient ID: TCMC1556
Formula: C9H10O3

Ingredient ID: TCMC1436
Formula: C20H30O2

Ingredient ID: TCMC1417
Formula: C8H8O3

Ingredient ID: TCMC1387
Formula: C20H23NO4

Ingredient ID: TCMC1173
Formula: C10H10O4

Properties

Ingredient ID Formulae Name MW AlogP MlogP XlogP # HBA # HBD PSA # Rotatable Bond # Ring # Heacy Atom Lipinski RO5 Violation
TCMC6 C20H23NO4 (-)-Corydalmine 341.16 -0.3117 3.11 2.029 1 1 51.16 7 4 25 0
TCMC338 C8H8O4 2,6-Dimethoxyquinone 168.04 -0.8026 1.9 0.252 4 0 52.6 4 1 12 0
TCMC495 C7H6O2 4-Hydroxybenzaldehyde 122.04 -0.6527 2.01 1.484 1 1 37.3 2 1 9 0
TCMC553 C6H6O3 5-Hydroxymethyl-Furfural 126.03 -0.7952 1.79 0.422 2 1 50.44 3 1 9 0
TCMC801 C29H50O Beta-Sitosterol 414.39 1.3 4.54 11.595 1 1 20.23 13 4 30 1
TCMC848 C17H17NO3 Caffeic Acid Phenethyl Amide 283.12 -0.5981 2.89 5.037 2 3 73.05 8 2 21 1
TCMC995 C35H60O6 Daucosterol 576.44 -0.4469 4.65 10.487 6 4 99.38 19 5 41 1
TCMC1173 C10H10O4 Ferulic Acid 194.06 -0.3908 2.12 1.231 2 2 66.76 6 1 14 0
TCMC1387 C20H23NO4 Isocorydine 341.16 -0.221 3.11 1.718 1 1 51.16 8 4 25 0
TCMC1417 C8H8O3 Isovanillin 152.05 -0.7045 2.01 1.04 1 1 46.53 4 1 11 0
TCMC1436 C20H30O2 Kaurenoic Acid 302.22 1.3222 3.44 6.629 2 1 37.3 4 4 22 1
TCMC1556 C9H10O3 Methyl 4-Methoxybenzoate 166.06 -0.0406 2.12 1.91 2 0 35.53 5 1 12 0
TCMC1566 C10H10O3 Methyl P-Hydroxycinnamate 178.06 -0.088 2.23 2.207 2 1 46.53 5 1 13 0
TCMC1582 C8H8O3 Methylparaben 152.05 -0.4491 2.01 1.391 2 1 46.53 4 1 11 0
TCMC1741 C6H5NO2 Niacin 123.03 -0.2398 1.79 0.637 3 1 50.19 2 1 9 0
TCMC1748 C20H23NO4 N-Methyllaurotetanine 341.16 -0.221 3.11 1.718 1 1 51.16 8 4 25 0
TCMC1814 C20H17NO5 Oxoglaucine 351.11 -0.471 3 1.827 2 0 66.88 8 4 26 0
TCMC1839 C7H6O3 Paraben 138.03 -0.7001 1.9 1.07 2 2 57.53 3 1 10 0
TCMC2107 C29H48O Stigmasterol 412.37 1.2566 4.54 11.071 1 1 20.23 12 4 30 1
TCMC2117 C22H26O8 Syringaresinol 418.16 -2.1258 3 0.796 2 2 95.84 12 4 30 0
TCMC2119 C9H10O5 Syringic Acid 198.05 -0.8037 1.9 0.182 2 2 75.99 7 1 14 0
TCMC2209 C9H12N2O6 Uridine 244.07 -2.5465 1.57 -1.782 8 4 122.82 6 2 17 0
TCMC2222 C8H8O4 Vanillic Acid 168.04 -0.7519 1.9 0.626 2 2 66.76 5 1 12 0
TCMC2223 C8H8O3 Vanillin 152.05 -0.7045 2.01 1.04 1 1 46.53 4 1 11 0
TCMC2317 C19H21NO4 Laurotetanine 327.15 -0.7569 3 1.479 1 2 59.95 7 4 24 0
TCMC2458 C35H58O6 Stigmasterol Glucoside 574.42 -0.4903 4.65 9.963 6 4 99.38 18 5 41 1
TCMC2506 C19H21NO4 (+)-Norisocorydine 327.15 -0.7569 3 1.479 1 2 59.95 7 4 24 0
TCMC2528 C18H13NO3 Lysicamine 291.09 -0.3674 3 3.348 2 0 48.42 4 4 22 0
TCMC2543 C19H21NO5 N-Trans-Feruloylmethoxytyramine 343.14 -0.7017 2.89 2.665 2 3 91.51 12 2 25 0
TCMC2566 C10H22O Decanol 158.17 -2.7014 2.45 4.265 1 1 20.23 10 0 11 0
TCMC2638 C15H22O9 3,4,5-Trimethoxyphenyl-Beta-D-Glucopyranoside 346.13 -2.3626 2.12 -0.607 5 4 127.07 13 2 24 0
TCMC2642 C17H9NO3 Liriodenine 275.06 -0.5665 2.89 3.275 2 0 48.42 0 5 21 0

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1. General Information of the Component  
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3. Putative Targets  
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