Component: Cortex berberidis 三棵针皮


Description of the Component

Component ID
TCMH1765
Latin Name
Cortex berberidis
English Name
root or bark of reddrop barberry
Chinese Pinyin Name
San Ke Zhen Pi
中文名
三棵针皮
TCM Properties
TCM Meridians
Therapeutic Class English
Therapeutic Class Chinese
Functions
Toxicity
NA
Geo-authentic habitats (道地产区)
NA
Reference
CFDA
Barcode ID
Barcode Source

TCM Prescriptions with the Component

Prescription ID Prescription English Name Prescription Chinese Name
TCMFx6476 Xiao Zhi Pills 消痔丸

Targeted Human Proteins by the Ingredient of Component

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT1 EHMT2 Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 Transferase Q96KQ7
TCMT11 HIF1A Hypoxia-inducible factor 1 alpha Transcription factor Q16665
TCMT125 GBA Beta-glucocerebrosidase Hydrolase P04062
TCMT17 POLB DNA polymerase beta Transferase P06746
TCMT18 GAA Lysosomal alpha-glucosidase Hydrolase P10253
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT34 CYP2D6 Cytochrome P450 2D6 Oxidoreductase P10635
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2


Targeted Pathogenic Microbes by the Ingredient of Component

Target ID Target Name
TCMT1438 Plasmodium falciparum
TCMT1465 Entamoeba histolytica

Ingredient Structrues

Ingredient ID: TCMC934
Formula: C20H19NO4

Ingredient ID: TCMC2602
Formula: C37H40N2O6

Ingredient ID: TCMC2383
Formula: C20H23NO4

Ingredient ID: TCMC2369
Formula: C38H42N2O6

Ingredient ID: TCMC1831
Formula: C21H22NO4

Ingredient ID: TCMC1424
Formula: C20H19NO4

Properties

Ingredient ID Formulae Name MW AlogP MlogP XlogP # HBA # HBD PSA # Rotatable Bond # Ring # Heacy Atom Lipinski RO5 Violation
TCMC934 C20H19NO4 Columbamine 338.14 -1.7924 3.11 2.45 0 1 51.8 7 4 25 0
TCMC1424 C20H19NO4 Jatrorrhizine 338.14 -1.5606 3.11 1.039 2 1 49.2 6 4 25 0
TCMC1831 C21H22NO4 Palmitine 352.15 -1.3839 3.22 2.969 0 0 40.8 8 4 26 0
TCMC2369 C38H42N2O6 Isotetrandrine 622.3 0.274 4.76 6.098 2 0 61.86 10 6 46 1
TCMC2383 C20H23NO4 Magnoflorine 342.17 -1.9843 3.11 1.008 0 2 58.92 8 4 25 0
TCMC2602 C37H40N2O6 608.29 -0.1345 4.65 5.579 2 1 72.86 9 6 45 1

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1. General Information of the Component  
2. TCM Prescriptions with the Component  
3. Putative Targets  
4. Activity & References for Filtering Putative Targets  
5. Ingredient Data & Chemical Structure Information (Properties, InChI, InChIkey, SMILES, etc.)