Component: Papaver somniferum 蜜罂粟壳


Description of the Component

Component ID
TCMH1489
Latin Name
Papaver somniferum
English Name
Opium poppy
Chinese Pinyin Name
Mi Ying Su Ke
中文名
蜜罂粟壳
TCM Properties
TCM Meridians
Therapeutic Class English
Therapeutic Class Chinese
Functions
Toxicity
NA
Geo-authentic habitats (道地产区)
NA
Reference
Chinese Pharmacopoeia (2015)
Barcode ID
ITSAD207-14
Barcode Source
BOLDSYSTEMS

TCM Prescriptions with the Component

Prescription ID Prescription English Name Prescription Chinese Name
TCMF852 Xuan Fei Zhi Sou Recipe 宣肺止嗽合剂

Targeted Human Proteins by the Ingredient of Component

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT1 EHMT2 Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 Transferase Q96KQ7
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT11 HIF1A Hypoxia-inducible factor 1 alpha Transcription factor Q16665
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT113 OPRD1 Delta opioid receptor GPCR P41143
TCMT116 OPRM1 Mu opioid receptor GPCR P35372
TCMT117 OPRK1 Kappa opioid receptor GPCR P41145
TCMT125 GBA Beta-glucocerebrosidase Hydrolase P04062
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT143 CA3 Carbonic anhydrase III Lyase P07451
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT158 EPHX2 Epoxide hydratase Lyase P34913
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT160 HTR7 Serotonin 7 (5-HT7) receptor GPCR P34969
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT166 AKR1C2 Aldo-keto reductase family 1 member C2 Oxidoreductase P52895
TCMT167 AKR1C3 Aldo-keto-reductase family 1 member C3 Oxidoreductase P42330
TCMT168 AKR1C4 Aldo-keto reductase family 1 member C4 Oxidoreductase P17516
TCMT17 POLB DNA polymerase beta Transferase P06746
TCMT18 GAA Lysosomal alpha-glucosidase Hydrolase P10253
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT213 SLC22A1 Solute carrier family 22 member 1 Transporter O15245
TCMT220 CYP2J2 Cytochrome P450 2J2 Oxidoreductase P51589
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT273 NR1H4 Bile acid receptor FXR Nuclear receptor Q96RI1
TCMT276 SLCO2B1 Solute carrier organic anion transporter family member 2B1 Transporter O94956
TCMT277 SLCO1B3 Solute carrier organic anion transporter family member 1B3 Transporter Q9NPD5
TCMT278 SLCO1B1 Solute carrier organic anion transporter family member 1B1 Transporter Q9Y6L6
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT281 DPP4 Dipeptidyl peptidase IV Unclassified P27487
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT307 KCNH2 HERG Ion channel Q12809
TCMT309 SLC22A2 Solute carrier family 22 member 2 Transporter O15244
TCMT31 CYP2C19 Cytochrome P450 2C19 Oxidoreductase P33261
TCMT311 SLC47A1 Multidrug and toxin extrusion protein 1 Transporter Q96FL8
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT336 IDO1 Indoleamine 2,3-dioxygenase Oxidoreductase P14902
TCMT34 CYP2D6 Cytochrome P450 2D6 Oxidoreductase P10635
TCMT36 HTR1A Serotonin 1a (5-HT1a) receptor GPCR P08908
TCMT37 HTR2A Serotonin 2a (5-HT2a) receptor GPCR P28223
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT41 IDH1 Isocitrate dehydrogenase [NADP] cytoplasmic Oxidoreductase O75874
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT588 DAO D-amino-acid oxidase Oxidoreductase P14920
TCMT6 NFKB1 Nuclear factor NF-kappa-B p105 subunit Transcription factor P19838
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT615 SENP8 Sentrin-specific protease 8 Protease Q96LD8
TCMT616 SENP7 Sentrin-specific protease 7 Protease Q9BQF6
TCMT617 SENP6 Sentrin-specific protease 6 Protease Q9GZR1
TCMT69 THRB Thyroid hormone receptor beta-1 Nuclear receptor P10828
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT789 PDE3A Phosphodiesterase 3A Hydrolase Q14432
TCMT790 PDE3B Phosphodiesterase 3B Hydrolase Q13370
TCMT792 PDE10A Phosphodiesterase 10A Hydrolase Q9Y233
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT80 MAPK1 MAP kinase ERK2 Kinase P28482
TCMT81 ALOX12 Arachidonate 12-lipoxygenase Oxidoreductase P18054
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT853 SIGMAR1 Sigma opioid receptor Unclassified Q99720
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT95 MPG DNA-3-methyladenine glycosylase Hydrolase P29372


Targeted Pathogenic Microbes by the Ingredient of Component

Target ID Target Name
TCMT1099 Neuraminidase
TCMT1104 Sortase
TCMT1108 Integrase
TCMT1109 Reverse transcriptase
TCMT1178 Actinomyces viscosus
TCMT1212 Verticillium dahliae
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1223 Staphylococcus epidermidis
TCMT1229 Enterococcus faecalis
TCMT1251 Candida albicans
TCMT1438 Plasmodium falciparum
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1462 Streptococcus mutans
TCMT1465 Entamoeba histolytica

Ingredient Structrues

Ingredient ID: TCMC995
Formula: C35H60O6

Ingredient ID: TCMC948
Formula: C9H8O3

Ingredient ID: TCMC930
Formula: C18H19NO3

Ingredient ID: TCMC929
Formula: C18H21NO3

Ingredient ID: TCMC923
Formula: C6H8O7

Ingredient ID: TCMC904
Formula: C5H14NO

Ingredient ID: TCMC847
Formula: C9H8O4

Ingredient ID: TCMC573
Formula: C10H10O4

Ingredient ID: TCMC538
Formula: C20H25NO4

Ingredient ID: TCMC51
Formula: C9H15NO

Ingredient ID: TCMC495
Formula: C7H6O2

Ingredient ID: TCMC48
Formula: C21H27NO4

Ingredient ID: TCMC442
Formula: C9H8O3

Ingredient ID: TCMC38
Formula: C19H21NO4

Ingredient ID: TCMC28
Formula: C19H27NO

Ingredient ID: TCMC265
Formula: C20H23NO4

Ingredient ID: TCMC264
Formula: C20H23NO4

Ingredient ID: TCMC2596
Formula: C20H25NO4

Ingredient ID: TCMC2565
Formula: C20H25NO4

Ingredient ID: TCMC2542
Formula: C30H48O

Ingredient ID: TCMC2514
Formula: C31H52O

Ingredient ID: TCMC2444
Formula: C19H23NO4

Ingredient ID: TCMC234
Formula: C21H25NO4

Ingredient ID: TCMC2338
Formula: C30H50O

Ingredient ID: TCMC2222
Formula: C8H8O4

Ingredient ID: TCMC2155
Formula: C19H21NO3

Ingredient ID: TCMC2053
Formula: C19H21NO4

Ingredient ID: TCMC2044
Formula: C20H14NO4

Ingredient ID: TCMC2040
Formula: C19H21NO4

Ingredient ID: TCMC2001
Formula: C19H27NO

Ingredient ID: TCMC1957
Formula: C20H19NO5

Ingredient ID: TCMC1882
Formula: C8H6O4

Ingredient ID: TCMC1857
Formula: C19H27NO

Ingredient ID: TCMC1839
Formula: C7H6O3

Ingredient ID: TCMC1838
Formula: C20H21NO4.ClH

Ingredient ID: TCMC1837
Formula: C20H21NO4

Ingredient ID: TCMC182
Formula: C9H8O4

Ingredient ID: TCMC1816
Formula: C18H21NO4

Ingredient ID: TCMC1795
Formula: C18H19NO3

Ingredient ID: TCMC1763
Formula: C22H23NO7

Ingredient ID: TCMC1760
Formula: C16H17NO3

Ingredient ID: TCMC1724
Formula: C19H21NO4

Ingredient ID: TCMC1723
Formula: C19H21NO3

Ingredient ID: TCMC1659
Formula: C20H19NO5

Ingredient ID: TCMC1657
Formula: C29H41NO4

Ingredient ID: TCMC1656
Formula: C21H23NO5

Ingredient ID: TCMC1600
Formula: C17H19NO3

Ingredient ID: TCMC1573
Formula: C17H24O8

Ingredient ID: TCMC1461
Formula: C21H27NO4

Ingredient ID: TCMC1374
Formula: C6H12O6

Ingredient ID: TCMC1341
Formula: C12H15NO3

Ingredient ID: TCMC1339
Formula: C18H21NO3

Ingredient ID: TCMC1329
Formula: C16H12O6

Ingredient ID: TCMC130
Formula: C20H19NO5

Ingredient ID: TCMC1258
Formula: C21H25NO4

Ingredient ID: TCMC122
Formula: C19H21NO4

Ingredient ID: TCMC121
Formula: C19H21NO3

Ingredient ID: TCMC1194
Formula: C4H4O4

Ingredient ID: TCMC105
Formula: C22H23NO7

Ingredient ID: TCMC104
Formula: C22H23NO7

Properties

Ingredient ID Formulae Name MW AlogP MlogP XlogP # HBA # HBD PSA # Rotatable Bond # Ring # Heacy Atom Lipinski RO5 Violation
TCMC28 C19H27NO (+)-Pentazocine 285.21 1.8055 3.33 4.091 1 1 23.47 7 3 21 0
TCMC38 C19H21NO4 (13Ar)-3,10-Dimethoxy-6,8,13,13A-Tetrahydro-5H-Isoquinolino[2,1-B]Isoquinoline-2,9-Diol 327.15 -0.7202 3 1.51 1 2 62.16 6 4 24 0
TCMC48 C21H27NO4 (1S)-1-[(3,4-Dimethoxyphenyl)Methyl]-6,7-Dimethoxy-2-Methyl-3,4-Dihydro-1H-Isoquinoline 357.19 0.1875 3.22 3.069 1 0 40.16 11 3 26 0
TCMC51 C9H15NO (1S,5R)-9-Methyl-9-Azabicyclo[3.3.1]Nonan-3-One 153.12 -1.0435 2.23 0.426 2 0 20.31 1 2 11 0
TCMC104 C22H23NO7 (3R)-6,7-Dimethoxy-3-(4-Methoxy-6-Methyl-7,8-Dihydro-5H-[1,3]Dioxolo[4,5-G]Isoquinolin-5-Yl)-3H-2-Benzofuran-1-One 413.15 -0.2673 3 2.133 3 0 75.69 8 5 30 0
TCMC105 C22H23NO7 (3R)-6,7-Dimethoxy-3-[(5R)-4-Methoxy-6-Methyl-7,8-Dihydro-5H-[1,3]Dioxolo[4,5-G]Isoquinolin-5-Yl]-3H-2-Benzofuran-1-One 413.15 -0.2673 3 2.133 3 0 75.69 8 5 30 0
TCMC121 C19H21NO3 (4R,12Bs)-7,9-Dimethoxy-3-Methyl-2,4,7A,13-Tetrahydro-1H-4,12-Methanobenzofuro[3,2-E]Isoquinoline 311.15 0.01 3.11 1.329 2 0 30.93 5 5 23 0
TCMC122 C19H21NO4 (4R,4As,7As,12Bs)-4A,9-Dihydroxy-3-Prop-2-Enyl-2,4,5,6,7A,13-Hexahydro-1H-4,12-Methanobenzofuro[3,2-E]Isoquinoline-7-One 327.15 -0.8484 3 0.612 3 2 70 4 5 24 0
TCMC130 C20H19NO5 (6,7-Dimethoxyisoquinolin-1-Yl)-(3,4-Dimethoxyphenyl)Methanone 353.13 -0.471 3 2.659 2 0 66.88 10 3 26 0
TCMC182 C9H8O4 (Z)-3-(3,4-Dihydroxyphenyl)Prop-2-Enoic Acid 180.04 -0.7993 2.01 1.141 2 3 77.76 5 1 13 0
TCMC234 C21H25NO4 1,2,9,10-Tetramethoxy-6-Methyl-5,6,6A,7-Tetrahydro-4H-Dibenzo[De,G]Quinoline 355.18 0.1875 3.22 2.237 1 0 40.16 9 4 26 0
TCMC264 C20H23NO4 14-(R)-2-Hydroxyl-3,9,10-Trimethoxytetrahyrdooxyprotoberberine 341.16 -0.3117 3.11 2.029 1 1 51.16 7 4 25 0
TCMC265 C20H23NO4 14-(S)-2-Hydroxyl-3,9,10-Trimethoxytetrahyrdooxyprotoberberine 341.16 -0.3117 3.11 2.029 1 1 51.16 7 4 25 0
TCMC442 C9H8O3 3-Coumaric Acid 164.05 -0.339 2.12 1.886 2 2 57.53 4 1 12 0
TCMC495 C7H6O2 4-Hydroxybenzaldehyde 122.04 -0.6527 2.01 1.484 1 1 37.3 2 1 9 0
TCMC538 C20H25NO4 5-[(6,7-Dimethoxy-2-Methyl-3,4-Dihydro-1H-Isoquinolin-1-Yl)Methyl]-2-Methoxyphenol 343.18 -0.221 3.11 2.55 1 1 51.16 10 3 25 0
TCMC573 C10H10O4 6,7-Dimethoxy-3H-2-Benzofuran-1-One 194.06 -0.1831 2.12 1.499 2 0 44.76 4 2 14 0
TCMC847 C9H8O4 Caffeic Acid 180.04 -0.7993 2.01 1.141 2 3 77.76 5 1 13 0
TCMC904 C5H14NO Choline 104.11 -1.5741 1.79 -0.837 1 1 20.23 6 0 7 0
TCMC923 C6H8O7 Citric Acid 192.03 -1.395 1.35 -2.247 7 4 132.13 9 0 13 0
TCMC929 C18H21NO3 Codeine 299.15 -0.19 3 0.433 4 1 41.93 4 5 22 0
TCMC930 C18H19NO3 Codeinone 297.14 -0.2751 3 1.308 2 0 38.77 3 5 22 0
TCMC948 C9H8O3 Coumaric Acid 164.05 -0.339 2.12 1.886 2 2 57.53 4 1 12 0
TCMC995 C35H60O6 Daucosterol 576.44 -0.4469 4.65 10.487 6 4 99.38 19 5 41 1
TCMC1194 C4H4O4 Fumaric Acid 116.01 -0.2252 1.46 -0.416 4 2 74.6 4 0 8 0
TCMC1258 C21H25NO4 Glaucine 355.18 0.1875 3.22 2.237 1 0 40.16 9 4 26 0
TCMC1329 C16H12O6 Hispidulin 300.06 -1.9363 2.56 1.123 1 3 96.22 6 3 22 0
TCMC1339 C18H21NO3 Hydrocodone 299.15 -0.6176 3 1.426 2 0 38.77 3 5 22 0
TCMC1341 C12H15NO3 Hydrocotarnine 221.11 0.0398 2.34 0.77 1 0 30.93 3 3 16 0
TCMC1374 C6H12O6 Inositol 180.06 -3.0642 1.46 -1.458 6 6 121.38 6 1 12 1
TCMC1461 C21H27NO4 Laudanosine 357.19 0.1875 3.22 3.069 1 0 40.16 11 3 26 0
TCMC1573 C17H24O8 Methylconiferin 356.15 -1.8314 2.45 0.546 6 4 117.84 13 2 25 0
TCMC1600 C17H19NO3 Morphine 285.14 -0.2545 2.89 0.112 4 2 52.93 3 5 21 0
TCMC1656 C21H23NO5 369.16 -0.241 3.11 1.933 2 0 57.23 5 4 27 0
TCMC1657 C29H41NO4 467.3 0.8142 4.1 3.187 5 2 62.16 12 5 34 0
TCMC1659 C20H19NO5 353.13 -0.4401 3 1.86 2 0 57.23 1 5 26 0
TCMC1723 C19H21NO3 Nalorphine 311.15 0.3623 3.11 0.727 4 2 52.93 4 5 23 0
TCMC1724 C19H21NO4 Naloxone 327.15 -0.8484 3 0.612 3 2 70 4 5 24 0
TCMC1760 C16H17NO3 Normorphine 271.12 -0.7904 2.78 -0.127 4 3 61.72 2 5 20 0
TCMC1763 C22H23NO7 Noscapine 413.15 -0.2673 3 2.133 3 0 75.69 8 5 30 0
TCMC1795 C18H19NO3 Oripavine 297.14 -0.3985 3 0.81 2 1 41.93 4 5 22 0
TCMC1816 C18H21NO4 Oxycodone 315.15 -1.0567 2.89 0.516 3 1 59 4 5 23 0
TCMC1837 C20H21NO4 Papaverine 339.15 0.114 3.11 3.363 1 0 49.81 10 3 25 0
TCMC1838 C20H21NO4.ClH Papaverine Hydrochloride 339.15 0.114 3.11 3.363 1 0 49.81 10 3 25 0
TCMC1839 C7H6O3 Paraben 138.03 -0.7001 1.9 1.07 2 2 57.53 3 1 10 0
TCMC1857 C19H27NO Pentazocine 285.21 1.8055 3.33 4.091 1 1 23.47 7 3 21 0
TCMC1882 C8H6O4 Phthalic Acid 166.03 -0.4796 1.9 1.692 4 2 74.6 4 1 12 0
TCMC1957 C20H19NO5 Protopine 353.13 -0.4401 3 1.86 2 0 57.23 1 5 26 0
TCMC2001 C19H27NO Rel-Pentazocine 285.21 1.8055 3.33 4.091 1 1 23.47 7 3 21 0
TCMC2040 C19H21NO4 Salutaridine 327.15 -0.6163 3 1.283 3 1 59 6 4 24 0
TCMC2044 C20H14NO4 Sanguinarium 332.09 -1.947 3.11 3.297 0 0 40.8 1 6 25 0
TCMC2053 C19H21NO4 Scoulerine 327.15 -0.7202 3 1.51 1 2 62.16 6 4 24 0
TCMC2155 C19H21NO3 Thebaine 311.15 0.01 3.11 1.329 2 0 30.93 5 5 23 0
TCMC2222 C8H8O4 Vanillic Acid 168.04 -0.7519 1.9 0.626 2 2 66.76 5 1 12 0
TCMC2338 C30H50O Cycloartenol 426.39 3.2976 4.65 11.921 1 1 20.23 12 5 31 1
TCMC2444 C19H23NO4 (S)-Reticuline 329.16 -0.6295 3 2.031 1 2 62.16 9 3 24 0
TCMC2514 C31H52O Cyclolaudenol (24S) 440.4 3.0287 4.76 12.47 1 1 20.23 13 5 32 1
TCMC2542 C30H48O Cycloartenone 424.37 3.8673 4.65 11.314 1 0 17.07 11 5 31 1
TCMC2565 C20H25NO4 Laudanidine 343.18 -0.221 3.11 2.55 1 1 51.16 10 3 25 0
TCMC2596 C20H25NO4 Codamine 343.18 -0.221 3.11 2.55 1 1 51.16 10 3 25 0

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1. General Information of the Component  
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3. Putative Targets  
4. Activity & References for Filtering Putative Targets  
5. Ingredient Data & Chemical Structure Information (Properties, InChI, InChIkey, SMILES, etc.)