Component: Polygala tenuifolia 远志流浸膏


Description of the Component

Component ID
TCMH2556
Latin Name
Polygala tenuifolia
English Name
Thinleaf milkwort
Chinese Pinyin Name
Yuan Zhi Liu Jin Gao
中文名
远志流浸膏
TCM Properties
TCM Meridians
Therapeutic Class English
Therapeutic Class Chinese
Functions
Toxicity
NA
Geo-authentic habitats (道地产区)
NA
Reference
Chinese Pharmacopoeia (2015)
Barcode ID
MF096619
Barcode Source
GenBank

TCM Prescriptions with the Component

Prescription ID Prescription English Name Prescription Chinese Name
TCMFx4707 Lai Yang Li Zhi Ke Granules 莱阳梨止咳颗粒
TCMFx4715 Lai Yang Li Zhi Ke Oral Liquid 莱阳梨止咳口服液
TCMFx4723 Lai Yang Li Zhi Ke Syrup 莱阳梨止咳糖浆
TCMFx5503 Tian Yi Zhi Ke Syrup 天一止咳糖浆
TCMFx6202 Xing Ren Zhi Ke Infusion 杏仁止咳冲剂
TCMFx57 Xing Ren Zhi Ke Recipe 杏仁止咳合剂
TCMFx6586 Yuan Zhi Syrup 远志糖浆

Targeted Human Proteins by the Ingredient of Component

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT1 EHMT2 Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 Transferase Q96KQ7
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT125 GBA Beta-glucocerebrosidase Hydrolase P04062
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT151 PRKCA Protein kinase C alpha Kinase P17252
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT17 POLB DNA polymerase beta Transferase P06746
TCMT176 SOAT1 Acyl coenzyme A:cholesterol acyltransferase 1 Transferase P35610
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT195 MAP2K1 Dual specificity mitogen-activated protein kinase kinase 1 Kinase Q02750
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT226 PDPK1 3-phosphoinositide dependent protein kinase-1 Kinase O15530
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT265 GSK3B Glycogen synthase kinase-3 beta Kinase P49841
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT302 HMGCR HMG-CoA reductase Oxidoreductase P04035
TCMT307 KCNH2 HERG Ion channel Q12809
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT336 IDO1 Indoleamine 2,3-dioxygenase Oxidoreductase P14902
TCMT34 CYP2D6 Cytochrome P450 2D6 Oxidoreductase P10635
TCMT355 CSNK1D Casein kinase I delta Kinase P48730
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT407 MYLK Myosin light chain kinase, smooth muscle Kinase Q15746
TCMT41 IDH1 Isocitrate dehydrogenase [NADP] cytoplasmic Oxidoreductase O75874
TCMT417 DYRK2 Dual-specificity tyrosine-phosphorylation regulated kinase 2 Kinase Q92630
TCMT42 KMT2A Histone-lysine N-methyltransferase MLL Transferase Q03164
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT460 MAPKAPK2 MAP kinase-activated protein kinase 2 Kinase P49137
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT466 MAPK9 c-Jun N-terminal kinase 2 Kinase P45984
TCMT473 PIM3 Serine/threonine-protein kinase PIM3 Kinase Q86V86
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT507 MAPK14 MAP kinase p38 alpha Kinase Q16539
TCMT6 NFKB1 Nuclear factor NF-kappa-B p105 subunit Transcription factor P19838
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT634 SLC6A2 Norepinephrine transporter Transporter P23975
TCMT64 PPARD Peroxisome proliferator-activated receptor delta Nuclear receptor Q03181
TCMT67 PPARG Peroxisome proliferator-activated receptor gamma Nuclear receptor P37231
TCMT69 THRB Thyroid hormone receptor beta-1 Nuclear receptor P10828
TCMT751 DYRK1A Dual-specificity tyrosine-phosphorylation regulated kinase 1A Kinase Q13627
TCMT763 DYRK3 Dual-specificity tyrosine-phosphorylation regulated kinase 3 Kinase O43781
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT80 MAPK1 MAP kinase ERK2 Kinase P28482
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT81 ALOX12 Arachidonate 12-lipoxygenase Oxidoreductase P18054
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372


Targeted Pathogenic Microbes by the Ingredient of Component

Target ID Target Name
TCMT1104 Sortase
TCMT1136 Neuraminidase
TCMT1179 Escherichia coli ATCC 8739
TCMT1218 Staphylococcus aureus
TCMT1226 Klebsiella pneumoniae
TCMT1232 Pseudomonas aeruginosa
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1282 Colletotrichum orbiculare
TCMT1286 Bacillus cereus
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1408 Colletotrichum gloeosporioides
TCMT1438 Plasmodium falciparum
TCMT1442 Leishmania donovani
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1465 Entamoeba histolytica

Ingredient Structrues

Ingredient ID: TCMC995
Formula: C35H60O6

Ingredient ID: TCMC503
Formula: C10H10O3

Ingredient ID: TCMC489
Formula: C21H20O7

Ingredient ID: TCMC319
Formula: C15H12O4

Ingredient ID: TCMC281
Formula: C13H10N2O2

Ingredient ID: TCMC2688
Formula: C12H16O3

Ingredient ID: TCMC2481
Formula: C20H20O8

Ingredient ID: TCMC2404
Formula: C30H50

Ingredient ID: TCMC2363
Formula: C13H8O4

Ingredient ID: TCMC2305
Formula: C14H10O5

Ingredient ID: TCMC2264
Formula: C13H8O4

Ingredient ID: TCMC2180
Formula: C12H16O3

Ingredient ID: TCMC2105
Formula: C18H36O2

Ingredient ID: TCMC2084
Formula: C11H12O5

Ingredient ID: TCMC2083
Formula: C12H14O5

Ingredient ID: TCMC1969
Formula: C8H10

Ingredient ID: TCMC1922
Formula: C19H28O10

Ingredient ID: TCMC1921
Formula: C19H28O10

Ingredient ID: TCMC1863
Formula: C18H34O2

Ingredient ID: TCMC1830
Formula: C16H32O2

Ingredient ID: TCMC1788
Formula: C18H34O2

Ingredient ID: TCMC1769
Formula: C11H12O4

Ingredient ID: TCMC1759
Formula: C11H8N2

Ingredient ID: TCMC1651
Formula: C17H22O5

Ingredient ID: TCMC1578
Formula: C11H14O2

Ingredient ID: TCMC1495
Formula: C18H32O2

Ingredient ID: TCMC1308
Formula: C12H10N2

Ingredient ID: TCMC1150
Formula: C8H10

Ingredient ID: TCMC1134
Formula: C10H12O

Properties

Ingredient ID Formulae Name MW AlogP MlogP XlogP # HBA # HBD PSA # Rotatable Bond # Ring # Heacy Atom Lipinski RO5 Violation
TCMC281 C13H10N2O2 1-Methoxycarbonyl-Beta-Carboline 226.07 -0.4092 2.45 2.846 4 1 54.98 3 3 17 0
TCMC319 C15H12O4 2,3-Dimethoxyxanthen-9-One 256.07 -0.5215 2.67 2.826 1 0 44.76 4 3 19 0
TCMC489 C21H20O7 4'-Demethyldeoxypodophyllotoxin 384.12 -1.0772 3 1.77 2 1 83.45 6 5 28 0
TCMC503 C10H10O3 4-Methoxycinnamic Acid 178.06 0.0695 2.23 2.405 2 1 46.53 5 1 13 0
TCMC995 C35H60O6 Daucosterol 576.44 -0.4469 4.65 10.487 6 4 99.38 19 5 41 1
TCMC1134 C10H12O Estragole 148.09 0.9769 2.45 3.658 0 0 9.23 4 1 11 0
TCMC1150 C8H10 Ethylbenzene 106.08 0.3069 2.34 4.954 0 0 0 2 1 8 0
TCMC1308 C12H10N2 Harman 182.08 0.0191 2.56 2.968 2 1 28.68 1 3 14 0
TCMC1495 C18H32O2 Linoleic Acid 280.24 -0.9485 3.22 7.865 2 1 37.3 16 0 20 2
TCMC1578 C11H14O2 Methyleugenol 178.1 0.9251 2.45 3.003 0 0 18.46 6 1 13 0
TCMC1651 C17H22O5 306.15 -0.1413 2.78 0.702 5 1 72.83 5 4 22 0
TCMC1759 C11H8N2 Norharmane 168.07 -0.4204 2.45 2.471 2 1 28.68 0 3 13 0
TCMC1769 C11H12O4 O,O'-Dimethylcaffeic Acid 208.07 0.0177 2.23 1.75 2 1 55.76 7 1 15 0
TCMC1788 C18H34O2 Oleic Acid 282.26 -2.3427 3.22 8.192 2 1 37.3 17 0 20 2
TCMC1830 C16H32O2 Palmitic Acid 256.24 -3.8977 3 7.57 2 1 37.3 16 0 18 2
TCMC1863 C18H34O2 Petroselenic Acid 282.26 -2.3427 3.22 8.192 2 1 37.3 17 0 20 2
TCMC1921 C19H28O10 Polygalatenoside A 416.17 -3.6028 2.45 -0.13 10 6 158.3 13 3 29 1
TCMC1922 C19H28O10 Polygalatenoside B 416.17 -3.6028 2.45 -0.559 10 6 158.3 13 3 29 1
TCMC1969 C8H10 P-Xylene 106.08 1.284 2.34 4.708 0 0 0 2 1 8 0
TCMC2083 C12H14O5 Sinapic Acid Methyl Ether 238.08 -0.0341 2.23 1.306 2 1 64.99 9 1 17 0
TCMC2084 C11H12O5 Sinapinate 224.07 -0.4426 2.12 0.787 2 2 75.99 8 1 16 0
TCMC2105 C18H36O2 Stearic Acid 284.27 -4.4737 3.22 8.708 2 1 37.3 18 0 20 2
TCMC2180 C12H16O3 Trans-Asarone 208.11 0.7519 2.45 2.669 0 0 27.69 8 1 15 0
TCMC2264 C13H8O4 1,7-Dihydroxyxanthone 228.04 -1.3385 2.45 1.577 1 2 66.76 2 3 17 0
TCMC2305 C14H10O5 1,7-Dihydroxy-4-Methoxyxanthone 258.05 -1.3903 2.45 1.133 1 2 75.99 4 3 19 0
TCMC2363 C13H8O4 1,6-Dihydroxyxanthone 228.04 -1.3385 2.45 1.577 1 2 66.76 2 3 17 0
TCMC2404 C30H50 Squalene 410.39 8.5524 4.76 11.482 0 0 0 23 0 30 2
TCMC2481 C20H20O8 Artemetin 388.12 -1.563 2.78 1.957 2 1 92.68 12 3 28 0
TCMC2688 C12H16O3 Cis-Asarone 208.11 0.7519 2.45 2.669 0 0 27.69 8 1 15 0

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1. General Information of the Component  
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3. Putative Targets  
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