Component: Changium smyrnioides 明党参


Description of the Component

Component ID
TCMH1499
Latin Name
Changium smyrnioides
English Name
Medicinal changium
Chinese Pinyin Name
Ming Dang Shen
中文名
明党参
TCM Properties
Minor cold,Sweet,Slightly Bitter
TCM Meridians
Lung,Spleen,Liver
Therapeutic Class English
For tonifying weakness
Therapeutic Class Chinese
补虚
Functions
moisten the lung and resolve phlegm, nourish yin and regulate the function of the stomach, subdue hyperactivity of the liver, and counteract toxicity
Toxicity
NA
Geo-authentic habitats (道地产区)
Jiangsu Province,Shanghai
Reference
Chinese Classical Prescriptions
Barcode ID
Barcode Source

TCM Prescriptions with the Component

Prescription ID Prescription English Name Prescription Chinese Name
TCMF3883 Bu Pi Xiao Shi Tablets 补脾消食片
TCMF2304 Liver and Stomach Bai He Decoction 肝胃百合汤
TCMF3285 Shen Ling Jian Ti Fen 参苓健体粉
TCMF5392 Wan Ying Tea 万应茶

Targeted Human Proteins by the Ingredient of Component

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT1 EHMT2 Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 Transferase Q96KQ7
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT11 HIF1A Hypoxia-inducible factor 1 alpha Transcription factor Q16665
TCMT125 GBA Beta-glucocerebrosidase Hydrolase P04062
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT143 CA3 Carbonic anhydrase III Lyase P07451
TCMT158 EPHX2 Epoxide hydratase Lyase P34913
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT160 HTR7 Serotonin 7 (5-HT7) receptor GPCR P34969
TCMT17 POLB DNA polymerase beta Transferase P06746
TCMT18 GAA Lysosomal alpha-glucosidase Hydrolase P10253
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT207 BACE1 Beta-secretase 1 Protease P56817
TCMT208 MAOA Monoamine oxidase A Oxidoreductase P21397
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT213 SLC22A1 Solute carrier family 22 member 1 Transporter O15245
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT225 CA13 Carbonic anhydrase XIII Lyase Q8N1Q1
TCMT232 ABCB1 P-glycoprotein 1 Transporter P08183
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT265 GSK3B Glycogen synthase kinase-3 beta Kinase P49841
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT31 CYP2C19 Cytochrome P450 2C19 Oxidoreductase P33261
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT34 CYP2D6 Cytochrome P450 2D6 Oxidoreductase P10635
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT41 IDH1 Isocitrate dehydrogenase [NADP] cytoplasmic Oxidoreductase O75874
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT42 KMT2A Histone-lysine N-methyltransferase MLL Transferase Q03164
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT441 PTK2 Focal adhesion kinase 1 Kinase Q05397
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT6 NFKB1 Nuclear factor NF-kappa-B p105 subunit Transcription factor P19838
TCMT601 F2 Thrombin Unclassified P00734
TCMT61 MCL1 Induced myeloid leukemia cell differentiation protein Mcl-1 Unclassified Q07820
TCMT619 HSP90AA1 Heat shock protein HSP 90-alpha Unclassified P07900
TCMT620 HSPA8 Heat shock cognate 71 kDa protein Unclassified P11142
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT647 ADRA2B Alpha-2b adrenergic receptor GPCR P18089
TCMT69 THRB Thyroid hormone receptor beta-1 Nuclear receptor P10828
TCMT704 ERBB2 Receptor protein-tyrosine kinase erbB-2 Kinase P04626
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT751 DYRK1A Dual-specificity tyrosine-phosphorylation regulated kinase 1A Kinase Q13627
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT754 GSTP1 Glutathione S-transferase Pi Transferase P09211
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT757 CARM1 Histone-arginine methyltransferase CARM1 Transferase Q86X55
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT80 MAPK1 MAP kinase ERK2 Kinase P28482
TCMT81 ALOX12 Arachidonate 12-lipoxygenase Oxidoreductase P18054
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712


Targeted Pathogenic Microbes by the Ingredient of Component

Target ID Target Name
TCMT1090 Human immunodeficiency virus type 1 integrase
TCMT1108 Integrase
TCMT1109 Reverse transcriptase
TCMT1112 Quinolone resistance protein norA
TCMT1178 Actinomyces viscosus
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1222 Plasmodium falciparum D6
TCMT1246 Escherichia coli
TCMT1349 Helicobacter pylori SS1
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1465 Entamoeba histolytica

Ingredient Structrues

Ingredient ID: TCMC913
Formula: C15H14O6

Ingredient ID: TCMC904
Formula: C5H14NO

Ingredient ID: TCMC787
Formula: C12H8O4

Ingredient ID: TCMC731
Formula: C6H8O6

Ingredient ID: TCMC673
Formula: C29H50O2

Ingredient ID: TCMC4959
Formula: C13H22O2

Ingredient ID: TCMC491
Formula: C24H34N4O5S

Ingredient ID: TCMC4401
Formula: C18H32O2

Ingredient ID: TCMC4396
Formula: C18H34O2

Ingredient ID: TCMC4324
Formula: C29H48O

Ingredient ID: TCMC386
Formula: C31H46O2

Ingredient ID: TCMC2232
Formula: C29H50O2

Ingredient ID: TCMC2222
Formula: C8H8O4

Ingredient ID: TCMC2160
Formula: C12H17N4OS.2ClH

Ingredient ID: TCMC2159
Formula: C12H17N4OS.ClH

Ingredient ID: TCMC2158
Formula: C12H17N4OS

Ingredient ID: TCMC2016
Formula: C17H20N4O6

Ingredient ID: TCMC1961
Formula: C11H6O3

Ingredient ID: TCMC1866
Formula: C17H16O5

Ingredient ID: TCMC1858
Formula: C16H14O4

Ingredient ID: TCMC1535
Formula: C6H14O6

Ingredient ID: TCMC1404
Formula: C13H10O5

Ingredient ID: TCMC1395
Formula: C16H14O4

Ingredient ID: TCMC1102
Formula: C14H6O8

Properties

Ingredient ID Formulae Name MW AlogP MlogP XlogP # HBA # HBD PSA # Rotatable Bond # Ring # Heacy Atom Lipinski RO5 Violation
TCMC386 C31H46O2 2-Methyl-3-[(E)-3,7,11,15-Tetramethylhexadec-2-Enyl]Naphthalene-1,4-Dione 450.35 2.7425 4.65 12.011 2 0 34.14 20 2 33 2
TCMC491 C24H34N4O5S 4-Ethyl-3-Methyl-N-[2-[4-[(4-Methylcyclohexyl)Carbamoylsulfamoyl]Phenyl]Ethyl]-5-Oxo-2H-Pyrrole-1-Carboxamide 490.22 0.2885 3 4.487 9 3 140.04 14 3 34 0
TCMC673 C29H50O2 Alpha-Tochopherol 430.38 3.2935 4.43 10.938 0 1 29.46 21 2 31 2
TCMC731 C6H8O6 Ascorbate 176.03 -1.7593 1.46 -0.178 6 4 107.22 6 1 12 0
TCMC787 C12H8O4 Bergapten 216.04 0.0641 2.34 1.69 1 0 48.67 2 3 16 0
TCMC904 C5H14NO Choline 104.11 -1.5741 1.79 -0.837 1 1 20.23 6 0 7 0
TCMC913 C15H14O6 Cianidanol 290.08 -2.494 2.45 0.406 1 5 110.38 6 3 21 0
TCMC1102 C14H6O8 Ellagic Acid 302.01 -2.0234 2.12 -0.046 2 4 133.52 4 4 22 0
TCMC1395 C16H14O4 Isoimperatorin 270.09 1.5296 2.78 2.891 1 0 48.67 5 3 20 0
TCMC1404 C13H10O5 Isopimpinellin 246.05 0.0123 2.34 1.246 1 0 57.9 4 3 18 0
TCMC1535 C6H14O6 Mannitol 182.08 -2.9402 1.46 -3.896 6 6 121.38 11 0 12 1
TCMC1858 C16H14O4 Pentosalen 270.09 1.5296 2.78 2.891 1 0 48.67 5 3 20 0
TCMC1866 C17H16O5 Phellopterin 300.1 1.4778 2.78 2.447 1 0 57.9 7 3 22 0
TCMC1961 C11H6O3 Psoralen 186.03 0.1159 2.34 2.134 1 0 39.44 0 3 14 0
TCMC2016 C17H20N4O6 Riboflavin 376.14 -2.2465 2.23 0.067 10 5 158.54 12 3 27 0
TCMC2158 C12H17N4OS Thiamine 265.11 -2.3748 2.12 0.641 4 3 100.59 7 2 18 0
TCMC2159 C12H17N4OS.ClH Thiamine Chloride 265.11 -2.3748 2.12 0.641 4 3 100.59 7 2 18 0
TCMC2160 C12H17N4OS.2ClH Thiamine Hydrochloride 265.11 -2.3748 2.12 0.641 4 3 100.59 7 2 18 0
TCMC2222 C8H8O4 Vanillic Acid 168.04 -0.7519 1.9 0.626 2 2 66.76 5 1 12 0
TCMC2232 C29H50O2 Vitamin E 430.38 3.2935 4.43 10.938 0 1 29.46 21 2 31 2
TCMC4324 C29H48O Stigmasterol 412.3705162 1.2566 4.54 11.071 1 1 20.23 5 4 30 1
TCMC4396 C18H34O2 Isooleic Acid 281.2480553 -3.0205 3.22 7.711 2 0 40.13 15 0 20 2
TCMC4401 C18H32O2 Isolinolic Acid 279.2324052 -1.9767 3.22 7.267 2 0 40.13 14 0 20 2
TCMC4959 C13H22O2 Neryl Propionate 210.1619799 2.795 2.67 3.517 2 0 26.3 7 0 15 0

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