Component: Inula helenium 土木香


Description of the Component

Component ID
TCMH2144
Latin Name
Inula helenium
English Name
Elecampane inula
Chinese Pinyin Name
Tu Mu Xiang
中文名
土木香
TCM Properties
Warm,Pungent,Bitter
TCM Meridians
Spleen,Liver
Therapeutic Class English
Regulation of qi
Therapeutic Class Chinese
理气
Functions
invigorate the spleen and regulate the function of the stomach, relieve the depression of the liver qi, alleviate pain, and prevent abortion
Toxicity
NA
Geo-authentic habitats (道地产区)
Tibet, Hebei Province,Beijing,Tianjin
Reference
Chinese Pharmacopoeia (2015)
Barcode ID
ITSAJ4354-14
Barcode Source
BOLDSYSTEMS

TCM Prescriptions with the Component

Prescription ID Prescription English Name Prescription Chinese Name
TCMFx2026 Cuitang Pills 催汤丸
TCMFx1314 Cuitang Pills 催汤丸
TCMFx881 Guan Xin Su He Capsule 冠心苏合胶囊
TCMF6925 Jie Bai Capsules 洁白胶囊
TCMF2556 Jiebai Pills 洁白丸
TCMF1410 Jiebai Pills 洁白丸
TCMFx1070 Kang Fu Ointment 康妇软膏
TCMFx1830 Liuwei Anxiao Powder 六味安消散
TCMFx1273 Liuwei Anxiao Powder 六味安消散
TCMFx1936 Qiwei Tiexie Pills 七味铁屑丸
TCMFx1293 Qiwei Tiexie Pills 七味铁屑丸
TCMF6921 Shen Qi Jian Wei Granules 参芪健胃颗粒
TCMFx2579 Shiwuwei Chenxiang Pills 十五味沉香丸
TCMFx1420 Shiwuwei Chenxiang Pills 十五味沉香丸
TCMFx1383 Shiyiwei Nengxiao Pills 十一味能消丸
TCMFx2401 Shiyiwei Nengxiao Pills 十一味能消丸
TCMFx1228 Siwei Tumuxiang Powder 四味土木香散
TCMFx1590 Siwei Tumuxiang Powder 四味土木香散
TCMFx806 Wei Yao Capsule 胃药胶囊
TCMF7007 Xue Shan Wei Bao Pills 雪山胃宝丸

Targeted Human Proteins by the Ingredient of Component

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT1 EHMT2 Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 Transferase Q96KQ7
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT11 HIF1A Hypoxia-inducible factor 1 alpha Transcription factor Q16665
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT143 CA3 Carbonic anhydrase III Lyase P07451
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT166 AKR1C2 Aldo-keto reductase family 1 member C2 Oxidoreductase P52895
TCMT167 AKR1C3 Aldo-keto-reductase family 1 member C3 Oxidoreductase P42330
TCMT168 AKR1C4 Aldo-keto reductase family 1 member C4 Oxidoreductase P17516
TCMT17 POLB DNA polymerase beta Transferase P06746
TCMT176 SOAT1 Acyl coenzyme A:cholesterol acyltransferase 1 Transferase P35610
TCMT18 GAA Lysosomal alpha-glucosidase Hydrolase P10253
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT193 RELA Nuclear factor NF-kappa-B p65 subunit Transcription factor Q04206
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT276 SLCO2B1 Solute carrier organic anion transporter family member 2B1 Transporter O94956
TCMT277 SLCO1B3 Solute carrier organic anion transporter family member 1B3 Transporter Q9NPD5
TCMT278 SLCO1B1 Solute carrier organic anion transporter family member 1B1 Transporter Q9Y6L6
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT307 KCNH2 HERG Ion channel Q12809
TCMT31 CYP2C19 Cytochrome P450 2C19 Oxidoreductase P33261
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT327 TRPV1 Vanilloid receptor Ion channel Q8NER1
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT42 KMT2A Histone-lysine N-methyltransferase MLL Transferase Q03164
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT6 NFKB1 Nuclear factor NF-kappa-B p105 subunit Transcription factor P19838
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT64 PPARD Peroxisome proliferator-activated receptor delta Nuclear receptor Q03181
TCMT67 PPARG Peroxisome proliferator-activated receptor gamma Nuclear receptor P37231
TCMT69 THRB Thyroid hormone receptor beta-1 Nuclear receptor P10828
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT80 MAPK1 MAP kinase ERK2 Kinase P28482
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT95 MPG DNA-3-methyladenine glycosylase Hydrolase P29372


Targeted Pathogenic Microbes by the Ingredient of Component

Target ID Target Name
TCMT1108 Integrase
TCMT1183 Candida albicans SC5314
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1229 Enterococcus faecalis
TCMT1246 Escherichia coli
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1346 Helicobacter pylori
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1438 Plasmodium falciparum
TCMT1442 Leishmania donovani
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1462 Streptococcus mutans

Ingredient Structrues

Ingredient ID: TCMC946
Formula: C15H20O2

Ingredient ID: TCMC925
Formula: C12H22O2

Ingredient ID: TCMC897
Formula: C16H18O9

Ingredient ID: TCMC857
Formula: C10H16O

Ingredient ID: TCMC847
Formula: C9H8O4

Ingredient ID: TCMC671
Formula: C10H16

Ingredient ID: TCMC6105
Formula: C32H52O2

Ingredient ID: TCMC5816
Formula: C15H22O2

Ingredient ID: TCMC568
Formula: C15H20O2

Ingredient ID: TCMC473
Formula: C10H16O

Ingredient ID: TCMC304
Formula: C10H18O

Ingredient ID: TCMC284
Formula: C10H16

Ingredient ID: TCMC2803
Formula: C15H20O3

Ingredient ID: TCMC2629
Formula: C9H10

Ingredient ID: TCMC2541
Formula: C10H18O

Ingredient ID: TCMC2484
Formula: C10H18O

Ingredient ID: TCMC2399
Formula: C14H21N3O6S

Ingredient ID: TCMC2366
Formula: C15H24O

Ingredient ID: TCMC2349
Formula: C15H20O3

Ingredient ID: TCMC2346
Formula: C33H50O8

Ingredient ID: TCMC2324
Formula: C10H16

Ingredient ID: TCMC217
Formula: C19H26O5

Ingredient ID: TCMC2105
Formula: C18H36O2

Ingredient ID: TCMC1830
Formula: C16H32O2

Ingredient ID: TCMC182
Formula: C9H8O4

Ingredient ID: TCMC1788
Formula: C18H34O2

Ingredient ID: TCMC1752
Formula: C15H22O

Ingredient ID: TCMC1739
Formula: C12H20O2

Ingredient ID: TCMC1712
Formula: C15H24O

Ingredient ID: TCMC1495
Formula: C18H32O2

Ingredient ID: TCMC1493
Formula: C10H18O

Ingredient ID: TCMC1492
Formula: C10H18O

Ingredient ID: TCMC1379
Formula: C15H20O2

Ingredient ID: TCMC1312
Formula: C15H20O2

Ingredient ID: TCMC1157
Formula: C10H18O

Properties

Ingredient ID Formulae Name MW AlogP MlogP XlogP # HBA # HBD PSA # Rotatable Bond # Ring # Heacy Atom Lipinski RO5 Violation
TCMC182 C9H8O4 (Z)-3-(3,4-Dihydroxyphenyl)Prop-2-Enoic Acid 180.04 -0.7993 2.01 1.141 2 3 77.76 5 1 13 0
TCMC217 C19H26O5 [2-[4-Methyl-2-(2-Methylpropanoyloxy)Phenyl]Oxiran-2-Yl]Methyl 2-Methylbutanoate 334.18 0.8364 3 4.119 4 0 65.13 14 2 24 0
TCMC284 C10H16 1-Methyl-4-Prop-1-En-2-Ylcyclohexene 136.13 2.1424 2.56 3.729 0 0 0 3 1 10 0
TCMC304 C10H18O 2-(4-Methylcyclohex-3-En-1-Yl)Propan-2-Ol 154.14 1.1223 2.45 2.369 1 1 20.23 5 1 11 0
TCMC473 C10H16O 4,7,7-Trimethylbicyclo[2.2.1]Heptan-3-One 152.12 0.9693 2.45 2.127 1 0 17.07 3 2 11 0
TCMC568 C15H20O2 6,10-Dimethyl-3-Methylidene-3A,4,5,8,9,11A-Hexahydrocyclodeca[B]Furan-2-One 232.15 2.5287 2.89 3.308 2 0 26.3 2 2 17 0
TCMC671 C10H16 Alpha-Pinene 136.13 1.5162 2.56 4.177 0 0 0 3 1 10 0
TCMC847 C9H8O4 Caffeic Acid 180.04 -0.7993 2.01 1.141 2 3 77.76 5 1 13 0
TCMC857 C10H16O Camphor 152.12 0.9693 2.45 2.127 1 0 17.07 3 2 11 0
TCMC897 C16H18O9 Chlorogenic Acid 354.1 -2.1962 2.23 -0.447 7 6 164.75 11 2 25 1
TCMC925 C12H22O2 Citronellyl Acetate 198.16 1.8432 2.56 4.026 2 0 26.3 11 0 14 0
TCMC946 C15H20O2 Costunolide 232.15 2.5287 2.89 3.308 2 0 26.3 2 2 17 0
TCMC1157 C10H18O Eucalyptol 154.14 1.3109 2.45 2.595 1 0 9.23 3 0 11 0
TCMC1312 C15H20O2 Helenine 232.15 1.1063 2.89 3.443 2 0 26.3 2 3 17 0
TCMC1379 C15H20O2 Isoalantolactone 232.15 0.6791 2.89 3.681 2 0 26.3 1 3 17 0
TCMC1492 C10H18O Linalool 154.14 2.4692 2.45 2.468 1 1 20.23 8 0 11 0
TCMC1493 C10H18O Linalool (+) 154.14 2.4692 2.45 2.468 1 1 20.23 8 0 11 0
TCMC1495 C18H32O2 Linoleic Acid 280.24 -0.9485 3.22 7.865 2 1 37.3 16 0 20 2
TCMC1712 C15H24O 220.18 1.9144 3 4.607 1 0 12.53 3 3 16 0
TCMC1739 C12H20O2 Neryl Acetate 196.15 2.7188 2.56 3.264 2 0 26.3 10 0 14 0
TCMC1752 C15H22O Nootkatone 218.17 1.8291 3 3.754 1 0 17.07 4 2 16 0
TCMC1788 C18H34O2 Oleic Acid 282.26 -2.3427 3.22 8.192 2 1 37.3 17 0 20 2
TCMC1830 C16H32O2 Palmitic Acid 256.24 -3.8977 3 7.57 2 1 37.3 16 0 18 2
TCMC2105 C18H36O2 Stearic Acid 284.27 -4.4737 3.22 8.708 2 1 37.3 18 0 20 2
TCMC2324 C10H16 Limonene 136.13 2.1424 2.56 3.729 0 0 0 3 1 10 0
TCMC2346 C33H50O8 574.35 1.4283 4.21 5.403 8 3 130.36 19 4 41 1
TCMC2349 C15H20O3 Telekin 248.14 0.0648 2.78 1.468 3 1 46.53 2 3 18 0
TCMC2366 C15H24O 220.18 1.9144 3 4.607 1 0 12.53 3 3 16 0
TCMC2399 C14H21N3O6S Adicillin 359.12 -1.6415 1.9 -3.197 9 4 178.82 13 2 24 0
TCMC2484 C10H18O Terpineol 154.14 1.1223 2.45 1.947 1 1 20.23 5 1 11 0
TCMC2541 C10H18O Alpha-Terpineol 154.14 1.1223 2.45 2.369 1 1 20.23 5 1 11 0
TCMC2629 C9H10 [(E)-Prop-1-Enyl]Benzene 118.08 0.9073 2.45 5.478 0 0 0 2 1 9 1
TCMC2803 C15H20O3 248.14 0.0729 2.78 2.414 3 0 38.83 2 4 18 0
TCMC5816 C15H22O2 Dihydroisoalantolactone 234.1619799 0.462 2.89 3.863 2 0 26.3 0 3 17 0
TCMC6105 C32H52O2 3Β-Acetoxy-Dammara-20,24-Diene 468.3967309 4.5765 4.76 12.043 2 0 26.3 6 4 34 1

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1. General Information of the Component  
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3. Putative Targets  
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