Component: Datura metel 曼陀罗子

Description of the Component

Component ID
Latin Name
Datura metel
English Name
Hindu datura seed
Chinese Pinyin Name
Man Tuo Luo Zi
TCM Properties
TCM Meridians
Therapeutic Class English
Therapeutic Class Chinese
Geo-authentic habitats (道地产区)
Barcode ID
Barcode Source

TCM Prescriptions with the Component

Prescription ID Prescription English Name Prescription Chinese Name
TCMFx6255 Zhen Jiang Xiang Jiao Ointment 镇江橡胶膏

Targeted Human Proteins by the Ingredient of Component

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT1 EHMT2 Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 Transferase Q96KQ7
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT17 POLB DNA polymerase beta Transferase P06746
TCMT176 SOAT1 Acyl coenzyme A:cholesterol acyltransferase 1 Transferase P35610
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT248 CXCL8 Interleukin-8 Unclassified P10145
TCMT290 CHRM5 Muscarinic acetylcholine receptor M5 GPCR P08912
TCMT291 CHRM3 Muscarinic acetylcholine receptor M3 GPCR P20309
TCMT292 CHRM1 Muscarinic acetylcholine receptor M1 GPCR P11229
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT307 KCNH2 HERG Ion channel Q12809
TCMT31 CYP2C19 Cytochrome P450 2C19 Oxidoreductase P33261
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT42 KMT2A Histone-lysine N-methyltransferase MLL Transferase Q03164
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT6 NFKB1 Nuclear factor NF-kappa-B p105 subunit Transcription factor P19838
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT64 PPARD Peroxisome proliferator-activated receptor delta Nuclear receptor Q03181
TCMT67 PPARG Peroxisome proliferator-activated receptor gamma Nuclear receptor P37231
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT80 MAPK1 MAP kinase ERK2 Kinase P28482
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712

Targeted Pathogenic Microbes by the Ingredient of Component

Target ID Target Name
TCMT1455 Mycobacterium tuberculosis H37Rv

Ingredient Structrues

Ingredient ID: TCMC50
Formula: C8H15NO

Ingredient ID: TCMC2006
Formula: C20H30O

Ingredient ID: TCMC200
Formula: C17H23NO3

Ingredient ID: TCMC1788
Formula: C18H34O2

Ingredient ID: TCMC1626
Formula: C8H13NO2

Ingredient ID: TCMC1495
Formula: C18H32O2

Ingredient ID: TCMC1107
Formula: C17H23NO3


Ingredient ID Formulae Name MW AlogP MlogP XlogP # HBA # HBD PSA # Rotatable Bond # Ring # Heacy Atom Lipinski RO5 Violation
TCMC50 C8H15NO (1S,5R)-8-Methyl-8-Azabicyclo[3.2.1]Octan-3-Ol 141.12 -1.648 2.12 0.477 2 1 23.47 2 2 10 0
TCMC200 C17H23NO3 [(1S,5R)-8-Methyl-8-Azabicyclo[3.2.1]Octan-3-Yl] (2R)-3-Hydroxy-2-Phenylpropanoate 289.17 -1.8722 2.89 3.538 4 1 49.77 7 3 21 0
TCMC1107 C17H23NO3 Endo-Atropine 289.17 -1.8722 2.89 3.538 4 1 49.77 7 3 21 0
TCMC1495 C18H32O2 Linoleic Acid 280.24 -0.9485 3.22 7.865 2 1 37.3 16 0 20 2
TCMC1626 C8H13NO2 155.09 -1.3269 2.01 -0.565 3 1 32.7 2 2 11 0
TCMC1788 C18H34O2 Oleic Acid 282.26 -2.3427 3.22 8.192 2 1 37.3 17 0 20 2
TCMC2006 C20H30O Retinol 286.23 3.7849 3.55 6.158 1 1 20.23 11 1 21 1

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