Component: Citrus medica 香橼皮


Description of the Component

Component ID
TCMH2282
Latin Name
Citrus medica
English Name
Wilson citron
Chinese Pinyin Name
Xiang Yuan Pi
中文名
香橼皮
TCM Properties
TCM Meridians
Therapeutic Class English
Therapeutic Class Chinese
Functions
Toxicity
NA
Geo-authentic habitats (道地产区)
NA
Reference
CFDA
Barcode ID
ITSAJ4663-14
Barcode Source
BOLDSYSTEMS

TCM Prescriptions with the Component

Prescription ID Prescription English Name Prescription Chinese Name
TCMFx1985 Pain Relieving recipe
TCMF2407 Stomach Pain Recipe 胃脘痛方

Targeted Human Proteins by the Ingredient of Component

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT1 EHMT2 Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 Transferase Q96KQ7
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT11 HIF1A Hypoxia-inducible factor 1 alpha Transcription factor Q16665
TCMT125 GBA Beta-glucocerebrosidase Hydrolase P04062
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT132 BCHE Butyrylcholinesterase Hydrolase P06276
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT158 EPHX2 Epoxide hydratase Lyase P34913
TCMT160 HTR7 Serotonin 7 (5-HT7) receptor GPCR P34969
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT17 POLB DNA polymerase beta Transferase P06746
TCMT171 PTPN6 Protein-tyrosine phosphatase 1C Hydrolase P29350
TCMT176 SOAT1 Acyl coenzyme A:cholesterol acyltransferase 1 Transferase P35610
TCMT18 GAA Lysosomal alpha-glucosidase Hydrolase P10253
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT191 STAT3 Signal transducer and activator of transcription 3 Transcription factor P40763
TCMT193 RELA Nuclear factor NF-kappa-B p65 subunit Transcription factor Q04206
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT207 BACE1 Beta-secretase 1 Protease P56817
TCMT208 MAOA Monoamine oxidase A Oxidoreductase P21397
TCMT214 MGLL Monoglyceride lipase Unclassified Q99685
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT225 CA13 Carbonic anhydrase XIII Lyase Q8N1Q1
TCMT232 ABCB1 P-glycoprotein 1 Transporter P08183
TCMT233 PTPN11 Protein-tyrosine phosphatase 2C Hydrolase Q06124
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT248 CXCL8 Interleukin-8 Unclassified P10145
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT265 GSK3B Glycogen synthase kinase-3 beta Kinase P49841
TCMT273 NR1H4 Bile acid receptor FXR Nuclear receptor Q96RI1
TCMT276 SLCO2B1 Solute carrier organic anion transporter family member 2B1 Transporter O94956
TCMT277 SLCO1B3 Solute carrier organic anion transporter family member 1B3 Transporter Q9NPD5
TCMT278 SLCO1B1 Solute carrier organic anion transporter family member 1B1 Transporter Q9Y6L6
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT307 KCNH2 HERG Ion channel Q12809
TCMT31 CYP2C19 Cytochrome P450 2C19 Oxidoreductase P33261
TCMT327 TRPV1 Vanilloid receptor Ion channel Q8NER1
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT337 XPO1 Exportin-1 Unclassified O14980
TCMT34 CYP2D6 Cytochrome P450 2D6 Oxidoreductase P10635
TCMT36 HTR1A Serotonin 1a (5-HT1a) receptor GPCR P08908
TCMT41 IDH1 Isocitrate dehydrogenase [NADP] cytoplasmic Oxidoreductase O75874
TCMT42 KMT2A Histone-lysine N-methyltransferase MLL Transferase Q03164
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT629 ABCC1 Multidrug resistance-associated protein 1 Transporter P33527
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT64 PPARD Peroxisome proliferator-activated receptor delta Nuclear receptor Q03181
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT67 PPARG Peroxisome proliferator-activated receptor gamma Nuclear receptor P37231
TCMT69 THRB Thyroid hormone receptor beta-1 Nuclear receptor P10828
TCMT747 ABCG2 ATP-binding cassette sub-family G member 2 Transporter Q9UNQ0
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT80 MAPK1 MAP kinase ERK2 Kinase P28482
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712


Targeted Pathogenic Microbes by the Ingredient of Component

Target ID Target Name
TCMT1099 Neuraminidase
TCMT1109 Reverse transcriptase
TCMT1112 Quinolone resistance protein norA
TCMT1212 Verticillium dahliae
TCMT1218 Staphylococcus aureus
TCMT1232 Pseudomonas aeruginosa
TCMT1246 Escherichia coli
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1289 Shigella dysenteriae
TCMT1318 Human T-lymphotropic virus 1
TCMT1352 Colletotrichum truncatum
TCMT1393 Vibrio sp.
TCMT1438 Plasmodium falciparum
TCMT1444 Fusarium oxysporum
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1465 Entamoeba histolytica

Ingredient Structrues

Ingredient ID: TCMC956
Formula: C17H14O4

Ingredient ID: TCMC926
Formula: C11H10O4

Ingredient ID: TCMC925
Formula: C12H22O2

Ingredient ID: TCMC924
Formula: C10H20O

Ingredient ID: TCMC923
Formula: C6H8O7

Ingredient ID: TCMC922
Formula: C10H16O

Ingredient ID: TCMC873
Formula: C19H19NO4

Ingredient ID: TCMC872
Formula: C10H14O

Ingredient ID: TCMC857
Formula: C10H16O

Ingredient ID: TCMC788
Formula: C11H6O4

Ingredient ID: TCMC787
Formula: C12H8O4

Ingredient ID: TCMC784
Formula: C20H18NO4

Ingredient ID: TCMC76
Formula: C15H12O7

Ingredient ID: TCMC674
Formula: C29H50O3

Ingredient ID: TCMC671
Formula: C10H16

Ingredient ID: TCMC668
Formula: C15H26O

Ingredient ID: TCMC598
Formula: C21H22O4

Ingredient ID: TCMC548
Formula: C28H34O15

Ingredient ID: TCMC484
Formula: C16H14O5

Ingredient ID: TCMC477
Formula: C16H14O5

Ingredient ID: TCMC474
Formula: C9H13NO2

Ingredient ID: TCMC473
Formula: C10H16O

Ingredient ID: TCMC304
Formula: C10H18O

Ingredient ID: TCMC284
Formula: C10H16

Ingredient ID: TCMC2822
Formula: C15H24

Ingredient ID: TCMC2815
Formula: C15H24

Ingredient ID: TCMC2550
Formula: C15H24

Ingredient ID: TCMC2541
Formula: C10H18O

Ingredient ID: TCMC2539
Formula: C10H16

Ingredient ID: TCMC2484
Formula: C10H18O

Ingredient ID: TCMC2450
Formula: C16H14O4

Ingredient ID: TCMC2435
Formula: C16H14O4

Ingredient ID: TCMC2404
Formula: C30H50

Ingredient ID: TCMC2324
Formula: C10H16

Ingredient ID: TCMC2281
Formula: C28H34O9

Ingredient ID: TCMC2204
Formula: C9H6O3

Ingredient ID: TCMC2123
Formula: C20H20O7

Ingredient ID: TCMC2111
Formula: C4H6O4

Ingredient ID: TCMC2051
Formula: C10H8O4

Ingredient ID: TCMC2050
Formula: C11H10O4

Ingredient ID: TCMC2031
Formula: C27H30O16

Ingredient ID: TCMC1996
Formula: C19H24O5

Ingredient ID: TCMC1860
Formula: C10H14O

Ingredient ID: TCMC1858
Formula: C16H14O4

Ingredient ID: TCMC1832
Formula: C16H30O2

Ingredient ID: TCMC1818
Formula: C16H16O6

Ingredient ID: TCMC1808
Formula: C9H13NO2

Ingredient ID: TCMC1803
Formula: C15H16O3

Ingredient ID: TCMC1771
Formula: C26H30O7

Ingredient ID: TCMC1752
Formula: C15H22O

Ingredient ID: TCMC1749
Formula: C21H22O8

Ingredient ID: TCMC1739
Formula: C12H20O2

Ingredient ID: TCMC1737
Formula: C10H18O

Ingredient ID: TCMC1735
Formula: C27H32O14

Ingredient ID: TCMC1633
Formula: C19H21NO4

Ingredient ID: TCMC1608
Formula: C10H16

Ingredient ID: TCMC1495
Formula: C18H32O2

Ingredient ID: TCMC1493
Formula: C10H18O

Ingredient ID: TCMC1492
Formula: C10H18O

Ingredient ID: TCMC1491
Formula: C26H30O8

Ingredient ID: TCMC1413
Formula: C10H8O4

Ingredient ID: TCMC1404
Formula: C13H10O5

Ingredient ID: TCMC1395
Formula: C16H14O4

Ingredient ID: TCMC1383
Formula: C19H21NO4

Ingredient ID: TCMC1321
Formula: C28H34O15

Ingredient ID: TCMC1320
Formula: C16H14O6

Ingredient ID: TCMC1239
Formula: C12H20O2

Ingredient ID: TCMC1238
Formula: C10H18O

Ingredient ID: TCMC1129
Formula: C19H17NO4

Ingredient ID: TCMC1081
Formula: C12H24O2

Ingredient ID: TCMC1065
Formula: C28H32O15

Properties

Ingredient ID Formulae Name MW AlogP MlogP XlogP # HBA # HBD PSA # Rotatable Bond # Ring # Heacy Atom Lipinski RO5 Violation
TCMC76 C15H12O7 (2R,3S)-2-(3,4-Dihydroxyphenyl)-3,5,7-Trihydroxy-2,3-Dihydrochromen-4-One 304.06 -2.9269 2.34 0.028 2 5 127.45 6 3 22 0
TCMC284 C10H16 1-Methyl-4-Prop-1-En-2-Ylcyclohexene 136.13 2.1424 2.56 3.729 0 0 0 3 1 10 0
TCMC304 C10H18O 2-(4-Methylcyclohex-3-En-1-Yl)Propan-2-Ol 154.14 1.1223 2.45 2.369 1 1 20.23 5 1 11 0
TCMC473 C10H16O 4,7,7-Trimethylbicyclo[2.2.1]Heptan-3-One 152.12 0.9693 2.45 2.127 1 0 17.07 3 2 11 0
TCMC474 C9H13NO2 4-[(1R)-1-Hydroxy-2-(Methylamino)Ethyl]Phenol 167.09 -1.2775 2.12 0.464 2 3 52.49 6 1 12 0
TCMC477 C16H14O5 4-[(3,3-Dimethyloxiran-2-Yl)Methoxy]Furo[3,2-G]Chromen-7-One 286.08 0.363 2.67 2.204 2 0 61.2 5 4 21 0
TCMC484 C16H14O5 4-[[(2R)-3,3-Dimethyloxiran-2-Yl]Methoxy]Furo[3,2-G]Chromen-7-One 286.08 0.363 2.67 2.204 2 0 61.2 5 4 21 0
TCMC548 C28H34O15 5-Hydroxy-2-(3-Hydroxy-4-Methoxyphenyl)-7-[3,4,5-Trihydroxy-6-[(3,4,5-Trihydroxy-6-Methyloxan-2-Yl)Oxymethyl]Oxan-2-Yl]Oxy-2,3-Dihydrochromen-4-One 610.19 -4.86 2.89 -1.489 10 8 234.29 17 5 43 1
TCMC598 C21H22O4 9-[(2E)-3,7-Dimethylocta-2,6-Dienoxy]Furo[3,2-G]Chromen-7-One 338.15 2.7618 3.33 4.713 1 0 48.67 9 3 25 0
TCMC668 C15H26O Alpha-Bisabolol 222.2 2.7502 3 4.085 1 1 20.23 9 1 16 0
TCMC671 C10H16 Alpha-Pinene 136.13 1.5162 2.56 4.177 0 0 0 3 1 10 0
TCMC674 C29H50O3 Alpha-Tocoquinone 446.38 3.0732 4.32 8.993 3 1 54.37 24 1 32 2
TCMC784 C20H18NO4 Berberine 336.12 -1.583 3.11 2.896 0 0 40.8 4 5 25 0
TCMC787 C12H8O4 Bergapten 216.04 0.0641 2.34 1.69 1 0 48.67 2 3 16 0
TCMC788 C11H6O4 Bergaptol 202.03 -0.3444 2.23 1.171 1 1 59.67 1 3 15 0
TCMC857 C10H16O Camphor 152.12 0.9693 2.45 2.127 1 0 17.07 3 2 11 0
TCMC872 C10H14O Carvacrol 150.1 0.7546 2.45 3.556 0 1 20.23 5 1 11 0
TCMC873 C19H19NO4 Caryachine 325.13 -0.6753 3 1.993 1 1 51.16 4 5 24 0
TCMC922 C10H16O Citral 152.12 2.4893 2.45 2.701 1 0 17.07 7 0 11 0
TCMC923 C6H8O7 Citric Acid 192.03 -1.395 1.35 -2.247 7 4 132.13 9 0 13 0
TCMC924 C10H20O Citronellol 156.15 1.4641 2.45 3.286 1 1 20.23 9 0 11 0
TCMC925 C12H22O2 Citronellyl Acetate 198.16 1.8432 2.56 4.026 2 0 26.3 11 0 14 0
TCMC926 C11H10O4 Citropten 206.06 0.1664 2.23 1.607 1 0 44.76 4 2 15 0
TCMC956 C17H14O4 Cryptocaryone 282.09 -0.1386 2.89 4.448 4 1 63.6 3 3 21 0
TCMC1065 C28H32O15 Diosmin 608.17 -4.9301 2.89 -0.819 10 8 234.29 17 5 43 1
TCMC1081 C12H24O2 Dodecanoate 200.18 -2.7457 2.56 5.294 2 1 37.3 12 0 14 1
TCMC1129 C19H17NO4 Escholtzine 323.12 -0.4659 3 2.439 1 0 40.16 1 6 24 0
TCMC1238 C10H18O Geraniol 154.14 2.3397 2.45 2.524 1 1 20.23 8 0 11 0
TCMC1239 C12H20O2 Geranyl Acetate 196.15 2.7188 2.56 3.264 2 0 26.3 10 0 14 0
TCMC1320 C16H14O6 Hesperetin 302.08 -1.8662 2.56 0.453 1 3 96.22 6 3 22 0
TCMC1321 C28H34O15 Hesperidin 610.19 -4.86 2.89 -1.489 10 8 234.29 17 5 43 1
TCMC1383 C19H21NO4 Isoboldine 327.15 -0.6295 3 1.199 1 2 62.16 7 4 24 0
TCMC1395 C16H14O4 Isoimperatorin 270.09 1.5296 2.78 2.891 1 0 48.67 5 3 20 0
TCMC1404 C13H10O5 Isopimpinellin 246.05 0.0123 2.34 1.246 1 0 57.9 4 3 18 0
TCMC1413 C10H8O4 Isoscopoletin 192.04 -0.2421 2.12 1.088 1 1 55.76 3 2 14 0
TCMC1491 C26H30O8 Limonin 470.19 -0.4484 3.44 1.644 7 0 104.57 5 7 34 0
TCMC1492 C10H18O Linalool 154.14 2.4692 2.45 2.468 1 1 20.23 8 0 11 0
TCMC1493 C10H18O Linalool (+) 154.14 2.4692 2.45 2.468 1 1 20.23 8 0 11 0
TCMC1495 C18H32O2 Linoleic Acid 280.24 -0.9485 3.22 7.865 2 1 37.3 16 0 20 2
TCMC1608 C10H16 Myrcene 136.13 3.0936 2.56 4.17 0 0 0 6 0 10 0
TCMC1633 C19H21NO4 327.15 -0.8847 3 1.547 1 2 62.16 7 4 24 0
TCMC1735 C27H32O14 Naringin 580.18 -4.8082 2.89 -1.045 10 8 225.06 15 5 41 1
TCMC1737 C10H18O Nerol 154.14 2.3397 2.45 2.524 1 1 20.23 8 0 11 0
TCMC1739 C12H20O2 Neryl Acetate 196.15 2.7188 2.56 3.264 2 0 26.3 10 0 14 0
TCMC1749 C21H22O8 Nobiletin 402.13 -0.8144 2.89 1.792 1 0 81.68 13 3 29 0
TCMC1752 C15H22O Nootkatone 218.17 1.8291 3 3.754 1 0 17.07 4 2 16 0
TCMC1771 C26H30O7 Obacunone 454.2 0.7128 3.55 2.69 6 0 95.34 6 6 33 0
TCMC1803 C15H16O3 Osthole 244.11 2.0956 2.78 3.521 1 0 35.53 6 2 18 0
TCMC1808 C9H13NO2 Oxedrine 167.09 -1.2775 2.12 0.464 2 3 52.49 6 1 12 0
TCMC1818 C16H16O6 Oxypeucedanin Hydrate 304.09 -0.4035 2.56 1.186 3 2 89.13 8 3 22 0
TCMC1832 C16H30O2 Palmitoleic Acid 254.22 -1.7667 3 7.054 2 1 37.3 15 0 18 2
TCMC1858 C16H14O4 Pentosalen 270.09 1.5296 2.78 2.891 1 0 48.67 5 3 20 0
TCMC1860 C10H14O Perillaldehyde 150.1 1.308 2.45 2.355 1 0 17.07 3 1 11 0
TCMC1996 C19H24O5 R-(+)-Marmin 332.16 0.4392 3 2.725 3 2 75.99 12 2 24 0
TCMC2031 C27H30O16 Rutin 610.15 -6.139 2.67 -1.188 11 10 265.52 17 5 43 2
TCMC2050 C11H10O4 Scoparone 206.06 0.1664 2.23 1.607 1 0 44.76 4 2 15 0
TCMC2051 C10H8O4 Scopoletin 192.04 -0.2421 2.12 1.088 1 1 55.76 3 2 14 0
TCMC2111 C4H6O4 Succinic Acid 118.03 -0.41 1.46 -0.71 4 2 74.6 5 0 8 0
TCMC2123 C20H20O7 Tangeretin 372.12 -0.7626 2.89 2.236 1 0 72.45 11 3 27 0
TCMC2204 C9H6O3 Umbelliferone 162.03 -0.1903 2.12 1.532 1 1 46.53 1 2 12 0
TCMC2281 C28H34O9 Nomilin 514.22 0.2549 3.55 2.498 8 0 121.64 9 6 37 0
TCMC2324 C10H16 Limonene 136.13 2.1424 2.56 3.729 0 0 0 3 1 10 0
TCMC2404 C30H50 Squalene 410.39 8.5524 4.76 11.482 0 0 0 23 0 30 2
TCMC2435 C16H14O4 Larrein 270.09 -0.8751 2.78 4.338 1 2 66.76 7 2 20 0
TCMC2450 C16H14O4 Pinostrobin 270.09 -0.9456 2.78 3.012 1 1 55.76 4 3 20 0
TCMC2484 C10H18O Terpineol 154.14 1.1223 2.45 1.947 1 1 20.23 5 1 11 0
TCMC2539 C10H16 Gamma-Terpinene 136.13 2.4017 2.56 3.852 0 0 0 4 1 10 0
TCMC2541 C10H18O Alpha-Terpineol 154.14 1.1223 2.45 2.369 1 1 20.23 5 1 11 0
TCMC2550 C15H24 (+)-Germacrene D 204.19 2.7967 3.11 6.294 0 0 0 4 1 15 1
TCMC2815 C15H24 Caryophyllene 204.19 3.2289 3.11 6.044 0 0 0 3 2 15 1
TCMC2822 C15H24 Alpha-Humulone 204.19 4.1708 3.11 5.94 0 0 0 4 1 15 1

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1. General Information of the Component  
2. TCM Prescriptions with the Component  
3. Putative Targets  
4. Activity & References for Filtering Putative Targets  
5. Ingredient Data & Chemical Structure Information (Properties, InChI, InChIkey, SMILES, etc.)