Component: Tribulus terrestris 刺蒺藜


Description of the Component

Component ID
TCMH320
Latin Name
Tribulus terrestris
English Name
Puncturevine caltrap
Chinese Pinyin Name
Ci Ji Li
中文名
刺蒺藜
TCM Properties
Warm,Bitter
TCM Meridians
Lung,Liver
Therapeutic Class English
For calming liver and containing wind
Therapeutic Class Chinese
平肝息风
Functions
subdue hyperactivity of the liver, promote blood circulation, dispel wind, clear the eye of opacity, and arrest itching
Toxicity
NA
Geo-authentic habitats (道地产区)
NA
Reference
Chinese Pharmacopoeia (2015)
Barcode ID
ITSAJ4258-14
Barcode Source
BOLDSYSTEMS

TCM Prescriptions with the Component

Prescription ID Prescription English Name Prescription Chinese Name
TCMF2348 Headach Syrup 头痛定糖浆

Targeted Human Proteins by the Ingredient of Component

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT1 EHMT2 Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 Transferase Q96KQ7
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT11 HIF1A Hypoxia-inducible factor 1 alpha Transcription factor Q16665
TCMT125 GBA Beta-glucocerebrosidase Hydrolase P04062
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT143 CA3 Carbonic anhydrase III Lyase P07451
TCMT151 PRKCA Protein kinase C alpha Kinase P17252
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT160 HTR7 Serotonin 7 (5-HT7) receptor GPCR P34969
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT17 POLB DNA polymerase beta Transferase P06746
TCMT186 MAOB Monoamine oxidase B Oxidoreductase P27338
TCMT195 MAP2K1 Dual specificity mitogen-activated protein kinase kinase 1 Kinase Q02750
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT208 MAOA Monoamine oxidase A Oxidoreductase P21397
TCMT226 PDPK1 3-phosphoinositide dependent protein kinase-1 Kinase O15530
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT265 GSK3B Glycogen synthase kinase-3 beta Kinase P49841
TCMT31 CYP2C19 Cytochrome P450 2C19 Oxidoreductase P33261
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT34 CYP2D6 Cytochrome P450 2D6 Oxidoreductase P10635
TCMT355 CSNK1D Casein kinase I delta Kinase P48730
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT407 MYLK Myosin light chain kinase, smooth muscle Kinase Q15746
TCMT417 DYRK2 Dual-specificity tyrosine-phosphorylation regulated kinase 2 Kinase Q92630
TCMT42 KMT2A Histone-lysine N-methyltransferase MLL Transferase Q03164
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT458 HASPIN Serine/threonine-protein kinase haspin Kinase Q8TF76
TCMT460 MAPKAPK2 MAP kinase-activated protein kinase 2 Kinase P49137
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT466 MAPK9 c-Jun N-terminal kinase 2 Kinase P45984
TCMT473 PIM3 Serine/threonine-protein kinase PIM3 Kinase Q86V86
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT507 MAPK14 MAP kinase p38 alpha Kinase Q16539
TCMT6 NFKB1 Nuclear factor NF-kappa-B p105 subunit Transcription factor P19838
TCMT751 DYRK1A Dual-specificity tyrosine-phosphorylation regulated kinase 1A Kinase Q13627
TCMT763 DYRK3 Dual-specificity tyrosine-phosphorylation regulated kinase 3 Kinase O43781
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT80 MAPK1 MAP kinase ERK2 Kinase P28482
TCMT814 CLK1 Dual specificty protein kinase CLK1 Kinase P49759
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT829 NISCH Nischarin Unclassified Q9Y2I1
TCMT831 DYRK4 Dual specificity tyrosine-phosphorylation-regulated kinase 4 Kinase Q9NR20
TCMT832 DYRK1B Dual specificity tyrosine-phosphorylation-regulated kinase 1B Kinase Q9Y463
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712


Targeted Pathogenic Microbes by the Ingredient of Component

Target ID Target Name
TCMT1218 Staphylococcus aureus
TCMT1223 Staphylococcus epidermidis
TCMT1246 Escherichia coli
TCMT1251 Candida albicans
TCMT1408 Colletotrichum gloeosporioides
TCMT1438 Plasmodium falciparum
TCMT1442 Leishmania donovani
TCMT1444 Fusarium oxysporum
TCMT1454 Bacillus subtilis
TCMT1463 Mycobacterium tuberculosis

Ingredient Structrues

Ingredient ID: TCMC2524
Formula: C34H28Br4N4O8

Ingredient ID: TCMC2512
Formula: C12H8S3

Ingredient ID: TCMC2500
Formula: C24H28N2O6

Ingredient ID: TCMC1767
Formula: C18H19NO4

Ingredient ID: TCMC1310
Formula: C12H10N2O

Ingredient ID: TCMC1309
Formula: C13H12N2O

Ingredient ID: TCMC1308
Formula: C12H10N2

Ingredient ID: TCMC1173
Formula: C10H10O4

Properties

Ingredient ID Formulae Name MW AlogP MlogP XlogP # HBA # HBD PSA # Rotatable Bond # Ring # Heacy Atom Lipinski RO5 Violation
TCMC1173 C10H10O4 Ferulic Acid 194.06 -0.3908 2.12 1.231 2 2 66.76 6 1 14 0
TCMC1308 C12H10N2 Harman 182.08 0.0191 2.56 2.968 2 1 28.68 1 3 14 0
TCMC1309 C13H12N2O Harmine 212.09 -0.0327 2.56 2.313 2 1 37.91 3 3 16 0
TCMC1310 C12H10N2O Harmol 198.08 -0.8687 2.45 2.112 3 2 44.89 1 3 15 0
TCMC1767 C18H19NO4 N-Trans-Feruloyl Tyramine 313.13 -0.6499 2.89 3.109 2 3 82.28 10 2 23 0
TCMC2500 C24H28N2O6 Terrestribisamide 440.19 -1.4664 3.22 3.384 4 4 124.1 17 2 32 1
TCMC2512 C12H8S3 Alpha-Terthienyl 247.98 1.7718 2.45 4.693 0 0 84.72 2 3 15 0
TCMC2524 C34H28Br4N4O8 Bastadin 13 935.86 1.875 3.44 8.378 4 6 189.28 10 4 50 2

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1. General Information of the Component  
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3. Putative Targets  
4. Activity & References for Filtering Putative Targets  
5. Ingredient Data & Chemical Structure Information (Properties, InChI, InChIkey, SMILES, etc.)