TCM-ID Component

Description of the Component

Component ID	TCMH799
Latin Name	Sinomenium acutum
English Name	Yellowmouth dutchmanspipe
Chinese Pinyin Name	Han Fang Ji
中文名	汉防己
TCM Properties	Cold,Pungent,Bitter
TCM Meridians	Bladder,Spleen,Kidney
Therapeutic Class English	For dispelling wind-dampness
Therapeutic Class Chinese	祛风湿
Functions	expel wind-dampness and alleviate pain, promote diuresis and relieve edema, eliminate phlegm and relieve asthma, lower blood pressure
Toxicity	NA
Geo-authentic habitats (道地产区)	NA
Reference	Chinese Pharmacopoeia (2015)
Barcode ID	ITSAJ4218-14
Barcode Source	BOLDSYSTEMS

TCM Prescriptions with the Component

Prescription ID	Prescription English Name	Prescription Chinese Name
TCMFx1943	Combined Chan Yi Nephritis Decoction
TCMFx2151	Decoction for Removing the Meridian Obstruction	宣痹汤
TCMFx2354	Decoction of Poria
TCMFx1572	Decoction of Stephaniae Tetrandrae	木防己汤
TCMF1799	Decoction of Stephaniae Tetrandrae and Astragali seu Hedysari, Tetrandra and Astragalus Decoction	防己黄芪汤
TCMF2563	Fengliaoxing Medicated Wine	冯了性药酒
TCMFx1851	Li Huang Heart Decay Decoction	蛎蝗汤
TCMF2424	Minor Life Extending Decoction	小续命汤
TCMFx1660	Pills of Stephaniae Tetrandrae, Zanthoxyli, Lepidii seu Descurainiae and Rhei	己椒苈黄丸
TCMFx2487	Prescription for General Severe Arthralgia	上中下通用痛风方
TCMFx1980	Relaxing Muscles and Tendons Capsule	伸筋丹胶囊
TCMFx1304	Relaxing Muscles and Tendons Capsule	伸筋丹胶囊
TCMF2181	Yang Warming Pulse Decoction	温阳通脉汤

Targeted Human Proteins by the Ingredient of Component

Target ID	Gene Symbol	Target Name	Target Class	Uniprot ID
TCMT2	MAPT	Microtubule-associated protein tau	Unclassified	P10636
TCMT33	CYP3A4	Cytochrome P450 3A4	Oxidoreductase	P08684

Targeted Pathogenic Microbes by the Ingredient of Component

Target ID	Target Name
TCMT1438	Plasmodium falciparum
TCMT1465	Entamoeba histolytica

Ingredient Structrues

Ingredient ID: TCMC722
Formula: C17H11NO7

Common Name	Aristolochic Acid
IUPAC Name	n.a.
Canonical SMILES	COc1cccc2c1cc(N(=O)=O)c1c2c2OCOc2cc1C(=O)O
Standard InCHI	InChI=1S/C17H11NO7/c1-23-12-4-2-3-8-9(12)5-11(18(21)22)14-10(17(19)20)6-13-16(15(8)14)25-7-24-13/h2-6H,7H2,1H3,(H,19,20)
Standard InCHIKey	BBFQZRXNYIEMAW-UHFFFAOYSA-N
External Identifiers	ChEMBL [CHEMBL93353]; PubChem [2236];
Reference of Component-Ingredient Pair	21526364

Occurrence of the ingredient across TCM components

Component ID	Latin Name	Pinyin Name	Chinese Name
TCMH799	Sinomenium acutum	Han Fang Ji	汉防己
TCMH2685	Aristolochia kaempferi	Zhu Sha Lian	朱砂莲
TCMH1693	Aristolochia debilis	Qing Mu Xiang	青木香
TCMH2239	Asarum sieboldii	Xi Xin	细辛
TCMH1680	Sinomenium acutum	Qing Feng Teng	青风藤
TCMH565	Stephania tetrandra	Fang Ji	防己
TCMH1531	Akebia quinata	Mu Tong	木通
TCMH718	Aristolochia manshuriensis	Guan Mu Tong	关木通
TCMH727	Aristolochia fangchi	Guang Fang Ji	广防己
TCMH1397	Aristolochia debilis	Ma Dou Ling	马兜铃

Ingredient ID: TCMC2666
Formula: C37H40N2O6

Common Name	n.a.
IUPAC Name	n.a.
Canonical SMILES	COc1cc2CCN([C@H]3c2c(c1O)Oc1cc2c(cc1OC)CCN([C@H]2Cc1ccc(Oc2cc(C3)ccc2OC)cc1)C)C
Standard InCHI	InChI=1S/C37H40N2O6/c1-38-14-12-24-19-31(42-4)33-21-27(24)28(38)16-22-6-9-26(10-7-22)44-32-18-23(8-11-30(32)41-3)17-29-35-25(13-15-39(29)2)20-34(43-5)36(40)37(35)45-33/h6-11,18-21,28-29,40H,12-17H2,1-5H3/t28-,29+/m0/s1
Standard InCHIKey	IIQSJHUEZBTSAT-URLMMPGGSA-N
External Identifiers	ChEMBL [CHEMBL500614]; PubChem [100257];
Reference of Component-Ingredient Pair	N/A

Occurrence of the ingredient across TCM components

Component ID	Latin Name	Pinyin Name	Chinese Name
TCMH799	Sinomenium acutum	Han Fang Ji	汉防己
TCMH1326	Physeter catodon	Long Xian Xiang	龙涎香
TCMH572	Radix stephaniae tetrandrae	Fen Fang Ji	粉防己
TCMH565	Stephania tetrandra	Fang Ji	防己

Ingredient ID: TCMC2383
Formula: C20H23NO4

Common Name	Magnoflorine
IUPAC Name	(6aS)-2,10-dimethoxy-6,6-dimethyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-6-ium-1,11-diol
Canonical SMILES	COc1ccc2c(c1O)c1c(O)c(OC)cc3c1[C@H](C2)[N+](C)(C)CC3
Standard InCHI	InChI=1S/C20H23NO4/c1-21(2)8-7-12-10-15(25-4)20(23)18-16(12)13(21)9-11-5-6-14(24-3)19(22)17(11)18/h5-6,10,13H,7-9H2,1-4H3,(H-,22,23)/p+1/t13-/m0/s1
Standard InCHIKey	YLRXAIKMLINXQY-ZDUSSCGKSA-O
External Identifiers	ChEMBL [CHEMBL235428]; PubChem [73337];
Reference of Component-Ingredient Pair	24709313

Occurrence of the ingredient across TCM components

Component ID	Latin Name	Pinyin Name	Chinese Name
TCMH1416	Thalictrum foliolosum	Ma Wei Lian	马尾连
TCMH799	Sinomenium acutum	Han Fang Ji	汉防己
TCMH2580	Coptis chinensis	Ze Xi Huang Lian	择细黄连
TCMH1693	Aristolochia debilis	Qing Mu Xiang	青木香
TCMH1765	Cortex berberidis	San Ke Zhen Pi	三棵针皮
TCMH1825	Litsea cubeba	Shan Jiang Zi	山姜子
TCMH2374	Phellodendron amurense	Yan Guan Huang Bai	盐关黄柏
TCMH388	Ziziphus jujuba	Da Zao	大枣
TCMH555	Potentilla discolor	Fan Bai Cao	翻白草
TCMH1680	Sinomenium acutum	Qing Feng Teng	青风藤
TCMH565	Stephania tetrandra	Fang Ji	防己
TCMH1102	Tinospora capillipes	Jin Guo Lan	金果榄
TCMH2376	Corydalis yanhusuo	Yan Hu Suo	延胡索
TCMH1516	Cocculus trilobus	Mu Fang Ji	木防己
TCMH140	Menispermum dauricum	Bei Dou Gen	北豆根
TCMH718	Aristolochia manshuriensis	Guan Mu Tong	关木通
TCMH727	Aristolochia fangchi	Guang Fang Ji	广防己
TCMH1764	Cortex berberidis	San Ke Zhen	三棵针
TCMH717	Phellodendron amurense	Guan Huang Bai	关黄柏
TCMH949	Phellodendron amurense	Huang Bai	黄柏
TCMH950	Phellodendron amurense	Huang Bai Fen	黄柏粉
TCMH951	Phellodendron amurense	Huang Bai Tan	黄柏炭
TCMH1397	Aristolochia debilis	Ma Dou Ling	马兜铃
TCMH511	Litsea cubeba	Dou Chi Jiang	豆豉姜
TCMH1812	Litsea cubeba	Shan Cang Zi	山苍子
TCMH283	Coptis chinensis	Chuan Huang Lian	川黄连
TCMH972	Coptis chinensis	Huang Lian	黄连
TCMH973	Coptis chinensis	Huang Lian Gan Jin Gao	黄连干浸膏
TCMH975	Coptis chinensis	Huang Lian Xu	黄连须
TCMH1064	Coptis chinensis	Jiang Huang Lian	姜黄连
TCMH1161	Coptis chinensis	Jiu Huang Lian	酒黄连
TCMH2330	Coptis chinensis	Xiong Huang Lian	雄黄连
TCMH2531	Coptis chinensis	Yu Huang Lian	萸黄连

Ingredient ID: TCMC1663
Formula: C38H42N2O6

Common Name	n.a.
IUPAC Name	n.a.
Canonical SMILES	COc1c(OC)cc2c3c1Oc1cc4c(cc1OC)CCN(C4Cc1ccc(Oc4cc(CC3N(CC2)C)ccc4OC)cc1)C
Standard InCHI	InChI=1S/C38H42N2O6/c1-39-15-13-25-20-32(42-4)34-22-28(25)29(39)17-23-7-10-27(11-8-23)45-33-19-24(9-12-31(33)41-3)18-30-36-26(14-16-40(30)2)21-35(43-5)37(44-6)38(36)46-34/h7-12,19-22,29-30H,13-18H2,1-6H3
Standard InCHIKey	WVTKBKWTSCPRNU-UHFFFAOYSA-N
External Identifiers	ChEMBL [CHEMBL367260]; PubChem [5422];
Reference of Component-Ingredient Pair	N/A

Occurrence of the ingredient across TCM components

Component ID	Latin Name	Pinyin Name	Chinese Name
TCMH1416	Thalictrum foliolosum	Ma Wei Lian	马尾连
TCMH799	Sinomenium acutum	Han Fang Ji	汉防己
TCMH1693	Aristolochia debilis	Qing Mu Xiang	青木香
TCMH985	Astragalus membranaceus	Huang Qi Ti Qu Ye	黄芪提取液
TCMH565	Stephania tetrandra	Fang Ji	防己
TCMH981	Astragalus membranaceus	Huang Qi	黄芪
TCMH983	Astragalus membranaceus	Huang Qi Gan Jin Gao	黄芪干浸膏
TCMH984	Astragalus membranaceus	Huang Qi Jin Gao	黄芪浸膏
TCMH1397	Aristolochia debilis	Ma Dou Ling	马兜铃

Properties

Ingredient ID	Formulae	Name	MW	AlogP	MlogP	XlogP	# HBA	# HBD	PSA	# Rotatable Bond	# Ring	# Heacy Atom	Lipinski RO5 Violation
TCMC722	C17H11NO7	Aristolochic Acid	341.05	0.0658	2.45	2.79	2	1	108.13	6	4	25	0
TCMC1663	C38H42N2O6		622.3	0.274	4.76	6.098	2	0	61.86	10	6	46	1
TCMC2383	C20H23NO4	Magnoflorine	342.17	-1.9843	3.11	1.008	0	2	58.92	8	4	25	0
TCMC2666	C37H40N2O6		608.29	-0.1345	4.65	5.579	2	1	72.86	9	6	45	1

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Data Section	Select to Download
1. General Information of the Component
2. TCM Prescriptions with the Component
3. Putative Targets
4. Activity & References for Filtering Putative Targets
5. Ingredient Data & Chemical Structure Information (Properties, InChI, InChIkey, SMILES, etc.)

Component: Sinomenium acutum 汉防己

Description of the Component

Component ID

Latin Name

English Name

Chinese Pinyin Name

中文名

TCM Properties

TCM Meridians

Therapeutic Class English

Therapeutic Class Chinese

Functions

Toxicity

Geo-authentic habitats (道地产区)

Reference

Barcode ID

Barcode Source

TCM Prescriptions with the Component

Targeted Human Proteins by the Ingredient of Component

Targeted Pathogenic Microbes by the Ingredient of Component

Ingredient Structrues

Ingredient ID: TCMC722

Occurrence of the ingredient across TCM components

Ingredient ID: TCMC2666

Occurrence of the ingredient across TCM components

Ingredient ID: TCMC2383

Occurrence of the ingredient across TCM components

Ingredient ID: TCMC1663

Occurrence of the ingredient across TCM components

Properties

Download Data