TCM-ID Component

Description of the Component

Component ID	TCMH1616
Latin Name	Thalictrum alpinum
English Name	tali falsehellebore herb
Chinese Pinyin Name	Pi Ma Cao
中文名	披麻草
TCM Properties
TCM Meridians
Therapeutic Class English
Therapeutic Class Chinese
Functions
Toxicity	NA
Geo-authentic habitats (道地产区)	NA
Reference	CFDA
Barcode ID	ITSAO241-14
Barcode Source	BOLDSYSTEMS

TCM Prescriptions with the Component

Prescription ID	Prescription English Name	Prescription Chinese Name
TCMFx6312	Yi Li Zhi Tong Pills	一粒止痛丸

Targeted Human Proteins by the Ingredient of Component

Target ID	Gene Symbol	Target Name	Target Class	Uniprot ID
TCMT2	MAPT	Microtubule-associated protein tau	Unclassified	P10636
TCMT3	ALOX15	Arachidonate 15-lipoxygenase	Oxidoreductase	P16050
TCMT33	CYP3A4	Cytochrome P450 3A4	Oxidoreductase	P08684
TCMT69	THRB	Thyroid hormone receptor beta-1	Nuclear receptor	P10828
TCMT8	KDM4E	Lysine-specific demethylase 4D-like	Oxidoreductase	B2RXH2
TCMT80	MAPK1	MAP kinase ERK2	Kinase	P28482

Targeted Pathogenic Microbes by the Ingredient of Component

Target ID	Target Name
TCMT1442	Leishmania donovani

Ingredient Structrues

Ingredient ID: TCMC2785
Formula: C37H40N2O7

Common Name	n.a.
IUPAC Name	n.a.
Canonical SMILES	COc1cc2CCN[C@@H]3c2c(c1O)Oc1c2CCN([C@H](c2cc(c1OC)OC)Cc1ccc(Oc2cc(C3)ccc2OC)cc1)C
Standard InCHI	InChI=1S/C37H40N2O7/c1-39-15-13-25-26-20-32(43-4)36(44-5)35(25)46-37-33-23(19-31(42-3)34(37)40)12-14-38-27(33)16-22-8-11-29(41-2)30(18-22)45-24-9-6-21(7-10-24)17-28(26)39/h6-11,18-20,27-28,38,40H,12-17H2,1-5H3/t27-,28-/m0/s1
Standard InCHIKey	MSEKZZNGEVAPPO-NSOVKSMOSA-N
External Identifiers	ChEMBL [CHEMBL3577068]; PubChem [156760];
Reference of Component-Ingredient Pair	N/A

Occurrence of the ingredient across TCM components

Component ID	Latin Name	Pinyin Name	Chinese Name
TCMH1616	Thalictrum alpinum	Pi Ma Cao	披麻草

Ingredient ID: TCMC2567
Formula: C38H42N2O7

Common Name	Thalrugosidine
IUPAC Name	n.a.
Canonical SMILES	COc1cc2CCN([C@@H]3c2c(c1O)Oc1c2CCN([C@H](c2cc(c1OC)OC)Cc1ccc(Oc2cc(C3)ccc2OC)cc1)C)C
Standard InCHI	InChI=1S/C38H42N2O7/c1-39-16-14-26-27-21-33(44-5)37(45-6)36(26)47-38-34-24(20-32(43-4)35(38)41)13-15-40(2)29(34)18-23-9-12-30(42-3)31(19-23)46-25-10-7-22(8-11-25)17-28(27)39/h7-12,19-21,28-29,41H,13-18H2,1-6H3/t28-,29-/m0/s1
Standard InCHIKey	NVIHKJYGMWNYEP-VMPREFPWSA-N
External Identifiers	ChEMBL [CHEMBL507858]; PubChem [5321920];
Reference of Component-Ingredient Pair	N/A

Occurrence of the ingredient across TCM components

Component ID	Latin Name	Pinyin Name	Chinese Name
TCMH1416	Thalictrum foliolosum	Ma Wei Lian	马尾连
TCMH1616	Thalictrum alpinum	Pi Ma Cao	披麻草

Ingredient ID: TCMC1761
Formula: C10H9NO3

Common Name	Noroxyhydrastinine
IUPAC Name	7,8-dihydro-6H-[1,3]dioxolo[4,5-g]isoquinolin-5-one
Canonical SMILES	OC1=NCCc2c1cc1OCOc1c2
Standard InCHI	InChI=1S/C10H9NO3/c12-10-7-4-9-8(13-5-14-9)3-6(7)1-2-11-10/h3-4H,1-2,5H2,(H,11,12)
Standard InCHIKey	VSOJKDUWYQCWFM-UHFFFAOYSA-N
External Identifiers	ChEMBL [CHEMBL449731]; PubChem [89047];
Reference of Component-Ingredient Pair	N/A

Occurrence of the ingredient across TCM components

Component ID	Latin Name	Pinyin Name	Chinese Name
TCMH1416	Thalictrum foliolosum	Ma Wei Lian	马尾连
TCMH2580	Coptis chinensis	Ze Xi Huang Lian	择细黄连
TCMH2374	Phellodendron amurense	Yan Guan Huang Bai	盐关黄柏
TCMH2376	Corydalis yanhusuo	Yan Hu Suo	延胡索
TCMH1616	Thalictrum alpinum	Pi Ma Cao	披麻草
TCMH717	Phellodendron amurense	Guan Huang Bai	关黄柏
TCMH949	Phellodendron amurense	Huang Bai	黄柏
TCMH950	Phellodendron amurense	Huang Bai Fen	黄柏粉
TCMH951	Phellodendron amurense	Huang Bai Tan	黄柏炭
TCMH283	Coptis chinensis	Chuan Huang Lian	川黄连
TCMH972	Coptis chinensis	Huang Lian	黄连
TCMH973	Coptis chinensis	Huang Lian Gan Jin Gao	黄连干浸膏
TCMH975	Coptis chinensis	Huang Lian Xu	黄连须
TCMH1064	Coptis chinensis	Jiang Huang Lian	姜黄连
TCMH1161	Coptis chinensis	Jiu Huang Lian	酒黄连
TCMH2330	Coptis chinensis	Xiong Huang Lian	雄黄连
TCMH2531	Coptis chinensis	Yu Huang Lian	萸黄连

Ingredient ID: TCMC131
Formula: C20H23NO4

Common Name	(6As)-2,9,10-Trimethoxy-6-Methyl-5,6,6A,7-Tetrahydro-4H-Dibenzo[De,G]Quinoline-1-Ol
IUPAC Name	(6aS)-2,9,10-trimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-1-ol
Canonical SMILES	COc1cc2c(cc1OC)C[C@H]1c3c2c(O)c(OC)cc3CCN1C
Standard InCHI	InChI=1S/C20H23NO4/c1-21-6-5-11-8-17(25-4)20(22)19-13-10-16(24-3)15(23-2)9-12(13)7-14(21)18(11)19/h8-10,14,22H,5-7H2,1-4H3/t14-/m0/s1
Standard InCHIKey	SAERKXUSZPTMCQ-AWEZNQCLSA-N
External Identifiers	ChEMBL [CHEMBL1397308]; PubChem [6992288];
Reference of Component-Ingredient Pair	8386090

Occurrence of the ingredient across TCM components

Component ID	Latin Name	Pinyin Name	Chinese Name
TCMH2376	Corydalis yanhusuo	Yan Hu Suo	延胡索
TCMH1616	Thalictrum alpinum	Pi Ma Cao	披麻草

Properties

Ingredient ID	Formulae	Name	MW	AlogP	MlogP	XlogP	# HBA	# HBD	PSA	# Rotatable Bond	# Ring	# Heacy Atom	Lipinski RO5 Violation
TCMC131	C20H23NO4	(6As)-2,9,10-Trimethoxy-6-Methyl-5,6,6A,7-Tetrahydro-4H-Dibenzo[De,G]Quinoline-1-Ol	341.16	-0.221	3.11	1.718	1	1	51.16	8	4	25	0
TCMC1761	C10H9NO3	Noroxyhydrastinine	191.06	-0.3413	2.12	1.117	2	1	51.05	1	3	14	0
TCMC2567	C38H42N2O7	Thalrugosidine	638.3	-0.1863	4.65	5.135	2	1	82.09	11	6	47	1
TCMC2785	C37H40N2O7		624.28	-0.7222	4.54	4.896	2	2	90.88	10	6	46	0

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Data Section	Select to Download
1. General Information of the Component
2. TCM Prescriptions with the Component
3. Putative Targets
4. Activity & References for Filtering Putative Targets
5. Ingredient Data & Chemical Structure Information (Properties, InChI, InChIkey, SMILES, etc.)

Component: Thalictrum alpinum 披麻草

Description of the Component

Component ID

Latin Name

English Name

Chinese Pinyin Name

中文名

TCM Properties

TCM Meridians

Therapeutic Class English

Therapeutic Class Chinese

Functions

Toxicity

Geo-authentic habitats (道地产区)

Reference

Barcode ID

Barcode Source

TCM Prescriptions with the Component

Targeted Human Proteins by the Ingredient of Component

Targeted Pathogenic Microbes by the Ingredient of Component

Ingredient Structrues

Ingredient ID: TCMC2785

Occurrence of the ingredient across TCM components

Ingredient ID: TCMC2567

Occurrence of the ingredient across TCM components

Ingredient ID: TCMC1761

Occurrence of the ingredient across TCM components

Ingredient ID: TCMC131

Occurrence of the ingredient across TCM components

Properties

Download Data