Component: Euphorbia lathyris 千金子


Description of the Component

Component ID
TCMH1658
Latin Name
Euphorbia lathyris
English Name
Caper euphorbia seed
Chinese Pinyin Name
Qian Jin Zi
中文名
千金子
TCM Properties
TCM Meridians
Therapeutic Class English
Purging
Therapeutic Class Chinese
泻下
Functions
cause drastic purgation for treating edema, and eliminate blood stasis for treating masses
Toxicity
NA
Geo-authentic habitats (道地产区)
Henan Province
Reference
Chinese Pharmacopoeia (2015)
Barcode ID
ITSAM343-14
Barcode Source
BOLDSYSTEMS

TCM Prescriptions with the Component

Prescription ID Prescription English Name Prescription Chinese Name
TCMFx3303 Dian Xian Ning Tablets 癫痫宁片
TCMFx5301 Wai Yong Zi Jin Ding 外用紫金锭

Targeted Human Proteins by the Ingredient of Component

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT1 EHMT2 Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 Transferase Q96KQ7
TCMT11 HIF1A Hypoxia-inducible factor 1 alpha Transcription factor Q16665
TCMT125 GBA Beta-glucocerebrosidase Hydrolase P04062
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT143 CA3 Carbonic anhydrase III Lyase P07451
TCMT154 PRKCD Protein kinase C delta Kinase Q05655
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT17 POLB DNA polymerase beta Transferase P06746
TCMT18 GAA Lysosomal alpha-glucosidase Hydrolase P10253
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT207 BACE1 Beta-secretase 1 Protease P56817
TCMT213 SLC22A1 Solute carrier family 22 member 1 Transporter O15245
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT225 CA13 Carbonic anhydrase XIII Lyase Q8N1Q1
TCMT232 ABCB1 P-glycoprotein 1 Transporter P08183
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT276 SLCO2B1 Solute carrier organic anion transporter family member 2B1 Transporter O94956
TCMT277 SLCO1B3 Solute carrier organic anion transporter family member 1B3 Transporter Q9NPD5
TCMT278 SLCO1B1 Solute carrier organic anion transporter family member 1B1 Transporter Q9Y6L6
TCMT281 DPP4 Dipeptidyl peptidase IV Unclassified P27487
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT336 IDO1 Indoleamine 2,3-dioxygenase Oxidoreductase P14902
TCMT337 XPO1 Exportin-1 Unclassified O14980
TCMT34 CYP2D6 Cytochrome P450 2D6 Oxidoreductase P10635
TCMT41 IDH1 Isocitrate dehydrogenase [NADP] cytoplasmic Oxidoreductase O75874
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT69 THRB Thyroid hormone receptor beta-1 Nuclear receptor P10828
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2


Targeted Pathogenic Microbes by the Ingredient of Component

Target ID Target Name
TCMT1243 Aspergillus flavus
TCMT1438 Plasmodium falciparum
TCMT1465 Entamoeba histolytica

Ingredient Structrues

Ingredient ID: TCMC991
Formula: C9H6O4

Ingredient ID: TCMC949
Formula: C9H6O2

Ingredient ID: TCMC801
Formula: C29H50O

Ingredient ID: TCMC7331
Formula: C36H58O6

Ingredient ID: TCMC6888
Formula: C18H10O8

Ingredient ID: TCMC4554
Formula: C18H10O8

Ingredient ID: TCMC4330
Formula: C20H30O4

Ingredient ID: TCMC2565
Formula: C20H25NO4

Ingredient ID: TCMC2204
Formula: C9H6O3

Ingredient ID: TCMC1658
Formula: C36H58O6

Ingredient ID: TCMC1474
Formula: C9H11NO4

Ingredient ID: TCMC1164
Formula: C32H40O8

Ingredient ID: TCMC1132
Formula: C15H16O9

Ingredient ID: TCMC1131
Formula: C9H6O4

Properties

Ingredient ID Formulae Name MW AlogP MlogP XlogP # HBA # HBD PSA # Rotatable Bond # Ring # Heacy Atom Lipinski RO5 Violation
TCMC801 C29H50O Beta-Sitosterol 414.39 1.3 4.54 11.595 1 1 20.23 13 4 30 1
TCMC949 C9H6O2 Coumarin 146.04 0.27 2.23 2.706 1 0 26.3 0 2 11 0
TCMC991 C9H6O4 Daphnetin 178.03 -0.6506 2.01 0.998 1 2 66.76 2 2 13 0
TCMC1131 C9H6O4 Esculetin 178.03 -0.6506 2.01 0.998 1 2 66.76 2 2 13 0
TCMC1132 C15H16O9 Esculin 340.08 -2.3975 2.12 -0.539 6 5 145.91 8 3 24 0
TCMC1164 C32H40O8 Euphorbiasteroid 552.27 0.7685 4.1 6.756 8 0 108.5 14 5 40 1
TCMC1474 C9H11NO4 Levodopa 197.07 -2.005 1.9 -2.111 3 4 103.78 7 1 14 0
TCMC1658 C36H58O6 586.42 -4.1511 4.76 9.868 6 3 104.06 25 4 42 2
TCMC2204 C9H6O3 Umbelliferone 162.03 -0.1903 2.12 1.532 1 1 46.53 1 2 12 0
TCMC2565 C20H25NO4 Laudanidine 343.18 -0.221 3.11 2.55 1 1 51.16 10 3 25 0
TCMC4330 C20H30O4 Lathyrol 334.2144094 0.3524 3.22 2.389 4 3 77.76 0 3 24 0
TCMC4554 C18H10O8 Euphorbetin 354.0375673 -1.2611 2.56 0.972 2 4 115.06 1 4 26 0
TCMC6888 C18H10O8 Isoeuphorbetin 354.0375673 -1.2611 2.56 0.972 5 4 115.06 1 4 26 0
TCMC7331 C36H58O6 20-Hexadecanoylingenol 586.4233396 -4.1511 4.76 9.868 6 3 104.06 17 4 42 2

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