NPASS Compound

Structure

CID246162 OpenBabel06191716042D 22 24 0 0 1 0 0 0 0 0999 V2000 -2.5981 -0.5000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -3.4641 -0.0000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -1.7321 1.0000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 2.5981 -1.5000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 1.7321 0.0000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -1.7321 -0.0000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 2.5981 -0.5000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -3.4641 1.0000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -2.5981 1.5000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 1.7321 -2.0000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 0.8660 -0.5000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 0.8660 -1.5000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 -2.0000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -0.8660 -1.5000 0.0000 C 0 0 1 0 0 0 0 0 0 0 0 0 -0.8660 -0.5000 0.0000 C 0 0 2 0 0 0 0 0 0 0 0 0 3.4641 0.0000 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 -4.3301 1.5000 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 -2.5981 2.5000 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 1.7321 -3.0000 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 -3.0000 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 -1.7321 -2.0000 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 0.0000 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 1 2 2 0 0 0 0 1 6 1 0 0 0 0 2 8 1 0 0 0 0 3 6 2 0 0 0 0 3 9 1 0 0 0 0 4 7 2 0 0 0 0 4 10 1 0 0 0 0 5 7 1 0 0 0 0 5 11 2 0 0 0 0 7 16 1 0 0 0 0 8 9 2 0 0 0 0 8 17 1 0 0 0 0 9 18 1 0 0 0 0 10 12 2 0 0 0 0 10 19 1 0 0 0 0 11 12 1 0 0 0 0 11 22 1 0 0 0 0 12 13 1 0 0 0 0 13 14 1 0 0 0 0 13 20 2 0 0 0 0 14 15 1 0 0 0 0 14 21 1 6 0 0 0 15 6 1 1 0 0 0 15 22 1 0 0 0 0 M END $$$$

Physi-Chem Properties

Molecular Weight:	304.06
Volume:	285.403
LogP:	0.449
LogD:	-0.142
LogS:	-2.662
# Rotatable Bonds:	1
TPSA:	127.45
# H-Bond Aceptor:	7
# H-Bond Donor:	5
# Rings:	3
# Heavy Atoms:	7

MedChem Properties

QED Drug-Likeness Score:	0.501
Synthetic Accessibility Score:	3.546
Fsp3:	0.133
Lipinski Rule-of-5:	Accepted
Pfizer Rule:	Accepted
GSK Rule:	Accepted
BMS Rule:	0
Golden Triangle Rule:	Accepted
Chelating Alert:	1
PAINS Alert:	1

ADMET Properties (ADMETlab2.0)

ADMET: Absorption

Caco-2 Permeability:	-6.055
MDCK Permeability:	4.002155492344173e-06
Pgp-inhibitor:	0.005
Pgp-substrate:	0.016
Human Intestinal Absorption (HIA):	0.014
20% Bioavailability (F20%):	0.892
30% Bioavailability (F30%):	0.678

ADMET: Distribution

Blood-Brain-Barrier Penetration (BBB):	0.031
Plasma Protein Binding (PPB):	85.44282531738281%
Volume Distribution (VD):	0.681
Pgp-substrate:	15.909717559814453%

ADMET: Metabolism

CYP1A2-inhibitor:	0.044
CYP1A2-substrate:	0.101
CYP2C19-inhibitor:	0.031
CYP2C19-substrate:	0.058
CYP2C9-inhibitor:	0.342
CYP2C9-substrate:	0.868
CYP2D6-inhibitor:	0.11
CYP2D6-substrate:	0.264
CYP3A4-inhibitor:	0.14
CYP3A4-substrate:	0.249

ADMET: Excretion

Clearance (CL):	9.517
Half-life (T1/2):	0.85

ADMET: Toxicity

hERG Blockers:	0.07
Human Hepatotoxicity (H-HT):	0.176
Drug-inuced Liver Injury (DILI):	0.943
AMES Toxicity:	0.544
Rat Oral Acute Toxicity:	0.24
Maximum Recommended Daily Dose:	0.423
Skin Sensitization:	0.932
Carcinogencity:	0.039
Eye Corrosion:	0.003
Eye Irritation:	0.911
Respiratory Toxicity:	0.296

Download Data

Data Type	Select
General Info & Identifiers & Properties
Structure MOL file
Source Organisms
Biological Activities
Similar NPs/Drugs

Natural Product: NPC246162

Natural Product ID:	NPC246162
*Common Name:**	(+)-Taxifolin
IUPAC Name:	(2R,3R)-2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-2,3-dihydrochromen-4-one
Synonyms:	Cianidanol
Standard InCHIKey:	CXQWRCVTCMQVQX-LSDHHAIUSA-N
Standard InCHI:	InChI=1S/C15H12O7/c16-7-4-10(19)12-11(5-7)22-15(14(21)13(12)20)6-1-2-8(17)9(18)3-6/h1-5,14-19,21H/t14-,15+/m0/s1
SMILES:	c1cc(c(cc1[C@@H]1[C@H](C(=O)c2c(cc(cc2O1)O)O)O)O)O
Synthetic Gene Cluster:	n.a.
ChEMBL Identifier:	CHEMBL66
PubChem CID:	439533
Chemical Classification:**	CHEMONTID:0000000 [Organic compounds] [CHEMONTID:0000261] Phenylpropanoids and polyketides [CHEMONTID:0000334] Flavonoids [CHEMONTID:0000337] Flavans [CHEMONTID:0001632] Flavanones [CHEMONTID:0001362] Flavanonols

*Note: the InCHIKey will be temporarily assigned as the "Common Name" if no IUPAC name or alternative short name is available.
**Note: the Chemical Classification was calculated by NPClassifier Version 1.5. Reference: PMID:34662515.

Species Source

Organism ID	Organism Name	Taxonomy Level	Family	SuperKingdom	Isolation Part	Collection Location	Collection Time	Reference
NPO21072	Rhododendron dauricum	Species	Ericaceae	Eukaryota	n.a.	whole plant	n.a.	DOI[10.1007/BF02329610]
NPO3057	Polygonum aviculare	Species	Polygonaceae	Eukaryota	n.a.	whole plant	n.a.	DOI[10.1016/S1572-557X(05)02007-6]
NPO13879	Humulus lupulus	Species	Cannabaceae	Eukaryota	n.a.	cone	n.a.	PMID[10336650]
NPO17675	Andira inermis	Species	Fabaceae	Eukaryota	n.a.	leaf	n.a.	PMID[11025148]
NPO12929	Polianthes tuberosa	Species	Asparagaceae	Eukaryota	aerial parts	n.a.	n.a.	PMID[11087596]
NPO6836	Alpinia blepharocalyx	Species	Zingiberaceae	Eukaryota	seeds	Mengha, Yunnan Province, China	1991-Aug	PMID[11277741]
NPO6836	Alpinia blepharocalyx	Species	Zingiberaceae	Eukaryota	seeds	n.a.	n.a.	PMID[11325233]
NPO6836	Alpinia blepharocalyx	Species	Zingiberaceae	Eukaryota	Seeds	n.a.	n.a.	PMID[11430002]
NPO20526	Menispermum dauricum	Species	Menispermaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[11473438]
NPO28450	Phyllanthus emblica	Species	Phyllanthaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[11754604]
NPO41837	A new engineered strain of Corynebacterium glutamicum [hom, lysC, pys]	Strain	Corynebacteriaceae	Bacteria	n.a.	n.a.	n.a.	PMID[11876415]
NPO19472	Thymus vulgaris	Species	Lamiaceae	Eukaryota	Leaves	n.a.	n.a.	PMID[12088434]
NPO11059	Callicarpa japonica	Species	Lamiaceae	Eukaryota	n.a.	leaf	n.a.	PMID[12165300]
NPO12929	Polianthes tuberosa	Species	Asparagaceae	Eukaryota	underground parts	n.a.	n.a.	PMID[12398537]
NPO22304	Morinda morindoides	Species	Rubiaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[12542353]
NPO21361	Anastatica hierochuntica	Species	Brassicaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[12643908]
NPO23205	Anthemis altissima	Species	n.a.	n.a.	n.a.	n.a.	n.a.	PMID[12762812]
NPO3261	Aplysina archeri	Species	Aplysinidae	Eukaryota	n.a.	n.a.	n.a.	PMID[1324982]
NPO6457	Pinus strobus	Species	Pinaceae	Eukaryota	n.a.	heartwood	n.a.	PMID[13465274]
NPO33256	green tea	n.a.	n.a.	n.a.	n.a.	n.a.	n.a.	PMID[14592472]
NPO12929	Polianthes tuberosa	Species	Asparagaceae	Eukaryota	fresh tubers	n.a.	n.a.	PMID[14738376]
NPO28952	Sapium haematospermum	Species	Euphorbiaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[15104489]
NPO21072	Rhododendron dauricum	Species	Ericaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[15270561]
NPO12181	Albizia julibrissin	Species	Fabaceae	Eukaryota	n.a.	bark	n.a.	PMID[15283458]
NPO17593	Pinus sylvestris	Species	Pinaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[1536925]
NPO12181	Albizia julibrissin	Species	Fabaceae	Eukaryota	n.a.	stem	n.a.	PMID[15577257]
NPO13879	Humulus lupulus	Species	Cannabaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[15679315]
NPO14054	Penicillium janczewskii	Species	Aspergillaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[16180822]
NPO25611	Smilax china	Species	Smilacaceae	Eukaryota	stems	n.a.	n.a.	PMID[16252910]
NPO13879	Humulus lupulus	Species	Cannabaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[16252923]
NPO5645	Silybum marianum	Species	Asteraceae	Eukaryota	n.a.	whole plant	n.a.	PMID[16394559]
NPO17782	Inula britannica	Species	Asteraceae	Eukaryota	flowers	n.a.	n.a.	PMID[16643020]
NPO19240	Ligularia cymbulifera	Species	Asteraceae	Eukaryota	Roots	n.a.	n.a.	PMID[16643057]
NPO4138.1	Betula platyphylla var. japonica	Varieties	Betulaceae	Eukaryota	floral spikes	n.a.	n.a.	PMID[17346076]
NPO422	Euphorbia cornigera	Species	Euphorbiaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[17512094]
NPO13879	Humulus lupulus	Species	Cannabaceae	Eukaryota	n.a.	cone	n.a.	PMID[17624889]
NPO22079	Paulownia tomentosa	Species	Paulowniaceae	Eukaryota	fruits	n.a.	n.a.	PMID[17625893]
NPO8080	Sarcophyton elegans	Species	Alcyoniidae	Eukaryota	n.a.	n.a.	n.a.	PMID[18004813]
NPO22079	Paulownia tomentosa	Species	Paulowniaceae	Eukaryota	Fruits	n.a.	n.a.	PMID[18293924]
NPO13879	Humulus lupulus	Species	Cannabaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[18611049]
NPO13879	Humulus lupulus	Species	Cannabaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[18768384]
NPO9060	Sinularia granosa	Species	Alcyoniidae	Eukaryota	n.a.	n.a.	n.a.	PMID[18831569]
NPO2687	Baphia bancoensis	Species	Fabaceae	Eukaryota	roots	n.a.	n.a.	PMID[19007285]
NPO17675	Andira inermis	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[19299148]
NPO28450	Phyllanthus emblica	Species	Phyllanthaceae	Eukaryota	Roots	Simao city, Yunnan Province, China	2007-MAY	PMID[19374435]
NPO422	Euphorbia cornigera	Species	Euphorbiaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[19376614]
NPO13879	Humulus lupulus	Species	Cannabaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[19476340]
NPO13135	Campylotropis hirtella	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[19481938]
NPO22304	Morinda morindoides	Species	Rubiaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[20149652]
NPO21361	Anastatica hierochuntica	Species	Brassicaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[20189399]
NPO22079	Paulownia tomentosa	Species	Paulowniaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[20192247]
NPO28265	Morus alba	Species	Moraceae	Eukaryota	n.a.	n.a.	n.a.	PMID[20815207]
NPO25224	Maytenus retusa	Species	Celastraceae	Eukaryota	n.a.	n.a.	n.a.	PMID[21090801]
NPO6062	Acacia mearnsii	Species	Fabaceae	Eukaryota	n.a.	bark	n.a.	PMID[21192716]
NPO19832	Gambierdiscus toxicus	Species	Goniodomataceae	Eukaryota	n.a.	n.a.	n.a.	PMID[21250701]
NPO22079	Paulownia tomentosa	Species	Paulowniaceae	Eukaryota	n.a.	fruit	n.a.	PMID[21319773]
NPO28265	Morus alba	Species	Moraceae	Eukaryota	n.a.	leaf	n.a.	PMID[21319773]
NPO28265	Morus alba	Species	Moraceae	Eukaryota	n.a.	root	n.a.	PMID[21319773]
NPO28265	Morus alba	Species	Moraceae	Eukaryota	n.a.	bark	n.a.	PMID[21319773]
NPO9888	Lobophytum laevigatum	Species	Alcyoniidae	Eukaryota	n.a.	Vietnamese	n.a.	PMID[21458279]
NPO9888	Lobophytum laevigatum	Species	Alcyoniidae	Eukaryota	n.a.	Vietnamese soft coral	n.a.	PMID[21507644]
NPO26559	Glycine soja	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[21545185]
NPO3648	Pittocaulon velatum	Species	Asteraceae	Eukaryota	n.a.	root	n.a.	PMID[21661732]
NPO3648	Pittocaulon velatum	Species	Asteraceae	Eukaryota	n.a.	stem	n.a.	PMID[21661732]
NPO19472	Thymus vulgaris	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[21707257]
NPO13879	Humulus lupulus	Species	Cannabaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[21912858]
NPO15265	Paeonia rockii	Species	Paeoniaceae	Eukaryota	n.a.	root	n.a.	PMID[21954959]
NPO15265	Paeonia rockii	Species	Paeoniaceae	Eukaryota	roots	Whitessence Srl, Viterbo, Italy	2005-OCT	PMID[21954959]
NPO30172	Pseudotsuga taxifolia	Species	Pinaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[21992235]
NPO13879	Humulus lupulus	Species	Cannabaceae	Eukaryota	n.a.	cone	n.a.	PMID[22111577]
NPO13879	Humulus lupulus	Species	Cannabaceae	Eukaryota	n.a.	flower	n.a.	PMID[22166201]
NPO28265	Morus alba	Species	Moraceae	Eukaryota	n.a.	leaf	n.a.	PMID[22207282]
NPO18007	Agrimonia pilosa	Species	Rosaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[22281186]
NPO22079	Paulownia tomentosa	Species	Paulowniaceae	Eukaryota	fruits	n.a.	n.a.	PMID[22445674]
NPO13726	Agrobacterium tumefaciens	Species	Rhizobiaceae	Bacteria	n.a.	n.a.	n.a.	PMID[22466953]
NPO9060	Sinularia granosa	Species	Alcyoniidae	Eukaryota	n.a.	n.a.	n.a.	PMID[22672798]
NPO15265	Paeonia rockii	Species	Paeoniaceae	Eukaryota	n.a.	seed	n.a.	PMID[23497864]
NPO22079	Paulownia tomentosa	Species	Paulowniaceae	Eukaryota	fruits	n.a.	n.a.	PMID[23623680]
NPO13879	Humulus lupulus	Species	Cannabaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[23790907]
NPO28265	Morus alba	Species	Moraceae	Eukaryota	n.a.	root	n.a.	PMID[23806866]
NPO17593	Pinus sylvestris	Species	Pinaceae	Eukaryota	n.a.	seed	n.a.	PMID[24225786]
NPO13726	Agrobacterium tumefaciens	Species	Rhizobiaceae	Bacteria	n.a.	n.a.	n.a.	PMID[24450804]
NPO5645	Silybum marianum	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	PMID[24456525]
NPO41671	Engineered Escherichia coli strain [GPP; sabinene synthase genes]	Strain	Enterobacteriaceae	Bacteria	n.a.	n.a.	n.a.	PMID[24512040]
NPO5645	Silybum marianum	Species	Asteraceae	Eukaryota	Seeds	n.a.	n.a.	PMID[24597776]
NPO28265	Morus alba	Species	Moraceae	Eukaryota	root bark	University of Veterinary and Pharmaceutical Sciences Brno (UVPS Brno), Brno, Czech Republic	2011-APR	PMID[24901948]
NPO28265	Morus alba	Species	Moraceae	Eukaryota	n.a.	Konya, Turkey	2007-APR	PMID[24901948]
NPO13879	Humulus lupulus	Species	Cannabaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[24948953]
NPO40928	Siberian larch	Species	n.a.	n.a.	n.a.	n.a.	n.a.	PMID[24963869]
NPO13879	Humulus lupulus	Species	Cannabaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[25564559]
NPO22079	Paulownia tomentosa	Species	Paulowniaceae	Eukaryota	fruits	n.a.	n.a.	PMID[25735399]
NPO28265	Morus alba	Species	Moraceae	Eukaryota	leaves	Chungbuk, Korea	n.a.	PMID[25935644]
NPO28265	Morus alba	Species	Moraceae	Eukaryota	n.a.	root	n.a.	PMID[25981820]
NPO25653	Spatholobus suberectus	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[26690274]
NPO9124	Inula japonica	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	PMID[27276091]
NPO28265	Morus alba	Species	Moraceae	Eukaryota	n.a.	latex	n.a.	PMID[27294120]
NPO18007	Agrimonia pilosa	Species	Rosaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[27588326]
NPO12796	Periploca sepium	Species	Apocynaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[28294615]
NPO22079	Paulownia tomentosa	Species	Paulowniaceae	Eukaryota	Fruits	n.a.	n.a.	PMID[28322565]
NPO41588	Another Engineered Escherichia coli strain [n.a.]	Strain	n.a.	n.a.	n.a.	n.a.	n.a.	PMID[28672185]
NPO40019	Anigozanthos pulcherrimus	Species	Haemodoraceae	Eukaryota	n.a.	n.a.	n.a.	PMID[28682615]
NPO27467	Anigozanthos rufus	Species	Haemodoraceae	Eukaryota	n.a.	n.a.	n.a.	PMID[28682615]
NPO22079	Paulownia tomentosa	Species	Paulowniaceae	Eukaryota	Fruits	n.a.	n.a.	PMID[28968119]
NPO13879	Humulus lupulus	Species	Cannabaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[29154541]
NPO28265	Morus alba	Species	Moraceae	Eukaryota	Root barks	n.a.	n.a.	PMID[3097265]
NPO865	Dendrobium loddigesii	Species	Orchidaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[31291099]
NPO16831	Hypericum patulum	Species	Hypericaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[31999455]
NPO40254	Opuntia humifusa	Species	Cactaceae	Eukaryota	Cladodes	n.a.	n.a.	PMID[32118424]
NPO15265	Paeonia rockii	Species	Paeoniaceae	Eukaryota	Seeds	DingXi, GanSu, China	early autumn (from August to the beginning of September	PMID[32545196]
NPO15265	Paeonia rockii	Species	Paeoniaceae	Eukaryota	Seeds	LanZhou, GanSu, China	early autumn (from August to the beginning of September	PMID[32545196]
NPO15265	Paeonia rockii	Species	Paeoniaceae	Eukaryota	Seeds	Yangling, Shaanxi, China	40 days after pollination	PMID[33131958]
NPO15265	Paeonia rockii	Species	Paeoniaceae	Eukaryota	Fruits	Yangling, Shaanxi, China	10 days after pollination	PMID[33131958]
NPO15265	Paeonia rockii	Species	Paeoniaceae	Eukaryota	Fruits	Yangling, Shaanxi, China	20 days after pollination	PMID[33131958]
NPO15265	Paeonia rockii	Species	Paeoniaceae	Eukaryota	Seeds	Yangling, Shaanxi, China	50 days after pollination	PMID[33131958]
NPO15265	Paeonia rockii	Species	Paeoniaceae	Eukaryota	Fruits	Yangling, Shaanxi, China	30 days after pollination	PMID[33131958]
NPO15265	Paeonia rockii	Species	Paeoniaceae	Eukaryota	Seeds	Yangling, Shaanxi, China	60 days after pollination	PMID[33131958]
NPO15265	Paeonia rockii	Species	Paeoniaceae	Eukaryota	Fruits	Yangling, Shaanxi, China	40 days after pollination	PMID[33131958]
NPO15265	Paeonia rockii	Species	Paeoniaceae	Eukaryota	Seeds	Yangling, Shaanxi, China	70 days after pollination	PMID[33131958]
NPO15265	Paeonia rockii	Species	Paeoniaceae	Eukaryota	Fruits	Yangling, Shaanxi, China	50 days after pollination	PMID[33131958]
NPO15265	Paeonia rockii	Species	Paeoniaceae	Eukaryota	Seeds	Yangling, Shaanxi, China	80 days after pollination	PMID[33131958]
NPO15265	Paeonia rockii	Species	Paeoniaceae	Eukaryota	Fruits	Yangling, Shaanxi, China	60 days after pollination	PMID[33131958]
NPO15265	Paeonia rockii	Species	Paeoniaceae	Eukaryota	Seeds	Yangling, Shaanxi, China	90 days after pollination	PMID[33131958]
NPO15265	Paeonia rockii	Species	Paeoniaceae	Eukaryota	Fruits	Yangling, Shaanxi, China	70 days after pollination	PMID[33131958]
NPO15265	Paeonia rockii	Species	Paeoniaceae	Eukaryota	Seeds	Yangling, Shaanxi, China	Maturation	PMID[33131958]
NPO15265	Paeonia rockii	Species	Paeoniaceae	Eukaryota	Fruits	Yangling, Shaanxi, China	80 days after pollination	PMID[33131958]
NPO15265	Paeonia rockii	Species	Paeoniaceae	Eukaryota	Fruits	Yangling, Shaanxi, China	90 days after pollination	PMID[33131958]
NPO15265	Paeonia rockii	Species	Paeoniaceae	Eukaryota	Fruits	Yangling, Shaanxi, China	Maturation	PMID[33131958]
NPO15265	Paeonia rockii	Species	Paeoniaceae	Eukaryota	Seeds	Yangling, Shaanxi, China	10 days after pollination	PMID[33131958]
NPO15265	Paeonia rockii	Species	Paeoniaceae	Eukaryota	Seeds	Yangling, Shaanxi, China	20 days after pollination	PMID[33131958]
NPO15265	Paeonia rockii	Species	Paeoniaceae	Eukaryota	Seeds	Yangling, Shaanxi, China	30 days after pollination	PMID[33131958]
NPO2697	Monodora tenuifolia	Species	Annonaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[3509958]
NPO22304	Morinda morindoides	Species	Rubiaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[7775983]
NPO20526	Menispermum dauricum	Species	Menispermaceae	Eukaryota	n.a.	rhizome	n.a.	PMID[8281582]
NPO12181	Albizia julibrissin	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[9051910]
NPO11059	Callicarpa japonica	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[9222055]
NPO6836	Alpinia blepharocalyx	Species	Zingiberaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[9461664]
NPO4138.1	Betula platyphylla var. japonica	Varieties	Betulaceae	Eukaryota	bark	n.a.	n.a.	PMID[9873651]
NPO3057	Polygonum aviculare	Species	Polygonaceae	Eukaryota	n.a.	n.a.	n.a.	Database[Article]
NPO19472	Thymus vulgaris	Species	Lamiaceae	Eukaryota	Leaf	n.a.	n.a.	Database[FooDB]
NPO27951	Vigna mungo	Species	Fabaceae	Eukaryota	Leaf Diffusate	n.a.	n.a.	Database[FooDB]
NPO19472	Thymus vulgaris	Species	Lamiaceae	Eukaryota	Plant	n.a.	n.a.	Database[FooDB]
NPO27951	Vigna mungo	Species	Fabaceae	Eukaryota	Seed	n.a.	n.a.	Database[FooDB]
NPO19472	Thymus vulgaris	Species	Lamiaceae	Eukaryota	Shoot	n.a.	n.a.	Database[FooDB]
NPO27951	Vigna mungo	Species	Fabaceae	Eukaryota	Sprout Seedling	n.a.	n.a.	Database[FooDB]
NPO19472	Thymus vulgaris	Species	Lamiaceae	Eukaryota		n.a.	n.a.	Database[FooDB]
NPO27951	Vigna mungo	Species	Fabaceae	Eukaryota		n.a.	n.a.	Database[FooDB]
NPO18599	Pangium edule	Species	Achariaceae	Eukaryota		n.a.	n.a.	Database[FooDB]
NPO19472	Thymus vulgaris	Species	Lamiaceae	Eukaryota	n.a.	n.a.		Database[FooDB]
NPO19472	Thymus vulgaris	Species	Lamiaceae	Eukaryota	Essential Oil	n.a.	n.a.	Database[FooDB]
NPO3057	Polygonum aviculare	Species	Polygonaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO16831	Hypericum patulum	Species	Hypericaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO6062	Acacia mearnsii	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO9357	Mitragyna inermis	Species	Rubiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO13135	Campylotropis hirtella	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO4564	Anguilla japonica	Species	Anguillidae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO19472	Thymus vulgaris	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO14715	Trollius chinensis	Species	Ranunculaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO12796	Periploca sepium	Species	Apocynaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO9124	Inula japonica	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO12935	Thymus quinquecostatus	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO22079	Paulownia tomentosa	Species	Paulowniaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO17675	Andira inermis	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO14012	Libanotis condensata	Species	Apiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO25181	Cyperus papyrus	Species	Cyperaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO7773	Crinum moorei	Species	Amaryllidaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO7132	Smilax glabra	Species	Smilacaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO4138.1	Betula platyphylla var. japonica	Varieties	Betulaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO20526	Menispermum dauricum	Species	Menispermaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO21072	Rhododendron dauricum	Species	Ericaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO5645	Silybum marianum	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO17782	Inula britannica	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO27620.1	Pteris cretica var. nervosa	Varieties	Pteridaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO14381	Swertia pseudochinensis	Species	Gentianaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO865	Dendrobium loddigesii	Species	Orchidaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO25611	Smilax china	Species	Smilacaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO25653	Spatholobus suberectus	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO6731	Ononis spinosa	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO14834	Trachelospermum asiaticum	Species	Apocynaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO12929	Polianthes tuberosa	Species	Asparagaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO28265	Morus alba	Species	Moraceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO6836	Alpinia blepharocalyx	Species	Zingiberaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO18007	Agrimonia pilosa	Species	Rosaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO12235	Trachelospermum jasminoides	Species	Apocynaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO28450	Phyllanthus emblica	Species	Phyllanthaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO13879	Humulus lupulus	Species	Cannabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO17593	Pinus sylvestris	Species	Pinaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO15786	Umbilicaria esculenta	Species	Umbilicariaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO19472	Thymus vulgaris	Species	Lamiaceae	Eukaryota	n.a.	n.a.		Database[Phenol-Explorer]
NPO12181	Albizia julibrissin	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO865	Dendrobium loddigesii	Species	Orchidaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO22079	Paulownia tomentosa	Species	Paulowniaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO25611	Smilax china	Species	Smilacaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO6826	Persicaria perfoliata	Species	Polygonaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO29658	Spinulum annotinum	Species	Lycopodiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO12235	Trachelospermum jasminoides	Species	Apocynaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO3031	Sabal causiarum	Species	Arecaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO14012	Libanotis condensata	Species	Apiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO13135	Campylotropis hirtella	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO11059	Callicarpa japonica	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO6836	Alpinia blepharocalyx	Species	Zingiberaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO20526	Menispermum dauricum	Species	Menispermaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO28450	Phyllanthus emblica	Species	Phyllanthaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO25653	Spatholobus suberectus	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO23213	Bistorta officinalis	Species	Polygonaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO6062	Acacia mearnsii	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO12929	Polianthes tuberosa	Species	Asparagaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO11508	Polygala reinii	Species	Polygalaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO22636	Sterculia foetida	Species	Malvaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO6731	Ononis spinosa	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO18007	Agrimonia pilosa	Species	Rosaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO9124	Inula japonica	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO17593	Pinus sylvestris	Species	Pinaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO14715	Trollius chinensis	Species	Ranunculaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO15843	Dalbergia retusa	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO14381	Swertia pseudochinensis	Species	Gentianaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO24089	Alcea rosea	Species	Malvaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO3057	Polygonum aviculare	Species	Polygonaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO22798	Pseudofumaria lutea	Species	Papaveraceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO13879	Humulus lupulus	Species	Cannabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO17675	Andira inermis	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO19472	Thymus vulgaris	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO21072	Rhododendron dauricum	Species	Ericaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO16978	Entada phaseoloides	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO12796	Periploca sepium	Species	Apocynaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO9357	Mitragyna inermis	Species	Rubiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO7132	Smilax glabra	Species	Smilacaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO17749	Jackiella javanica	Species	Jackiellaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO12935	Thymus quinquecostatus	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO25479	Sabal blackburniana	Species	Arecaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO5645	Silybum marianum	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO17782	Inula britannica	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO14834	Trachelospermum asiaticum	Species	Apocynaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO25716	Persicaria orientalis	Species	Polygonaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO2408	Millettia laurentii	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO15786	Umbilicaria esculenta	Species	Umbilicariaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO23205	Anthemis altissima	Species	n.a.	n.a.	n.a.	n.a.	n.a.	Database[TCMID]
NPO16831	Hypericum patulum	Species	Hypericaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO7773	Crinum moorei	Species	Amaryllidaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO4138.1	Betula platyphylla var. japonica	Varieties	Betulaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO28265	Morus alba	Species	Moraceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO27620.1	Pteris cretica var. nervosa	Varieties	Pteridaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO25181	Cyperus papyrus	Species	Cyperaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO4564	Anguilla japonica	Species	Anguillidae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO17593	Pinus sylvestris	Species	Pinaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO9124	Inula japonica	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO20526	Menispermum dauricum	Species	Menispermaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO14381	Swertia pseudochinensis	Species	Gentianaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO17782	Inula britannica	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO16978	Entada phaseoloides	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO21072	Rhododendron dauricum	Species	Ericaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO28265	Morus alba	Species	Moraceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO5645	Silybum marianum	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO12796	Periploca sepium	Species	Apocynaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO6731	Ononis spinosa	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO25611	Smilax china	Species	Smilacaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO12181	Albizia julibrissin	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO22079	Paulownia tomentosa	Species	Paulowniaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO19472	Thymus vulgaris	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO865	Dendrobium loddigesii	Species	Orchidaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO7132	Smilax glabra	Species	Smilacaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO22636	Sterculia foetida	Species	Malvaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO18007	Agrimonia pilosa	Species	Rosaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO28450	Phyllanthus emblica	Species	Phyllanthaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO13879	Humulus lupulus	Species	Cannabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO3057	Polygonum aviculare	Species	Polygonaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO12235	Trachelospermum jasminoides	Species	Apocynaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO25653	Spatholobus suberectus	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO13879	Humulus lupulus	Species	Cannabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TM-MC]
NPO3057	Polygonum aviculare	Species	Polygonaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TM-MC]
NPO23213	Bistorta officinalis	Species	Polygonaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TM-MC]
NPO26378	Bistorta manshuriensis	Species	Polygonaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TM-MC]
NPO28450	Phyllanthus emblica	Species	Phyllanthaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TM-MC]
NPO16978	Entada phaseoloides	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TM-MC]
NPO25716	Persicaria orientalis	Species	Polygonaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TM-MC]
NPO865	Dendrobium loddigesii	Species	Orchidaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TM-MC]
NPO28265	Morus alba	Species	Moraceae	Eukaryota	n.a.	n.a.	n.a.	Database[TM-MC]
NPO5645	Silybum marianum	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[TM-MC]
NPO25611	Smilax china	Species	Smilacaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TM-MC]
NPO25653	Spatholobus suberectus	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TM-MC]
NPO12935	Thymus quinquecostatus	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TM-MC]
NPO14834	Trachelospermum asiaticum	Species	Apocynaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TM-MC]
NPO14381	Swertia pseudochinensis	Species	Gentianaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TM-MC]
NPO6826	Persicaria perfoliata	Species	Polygonaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TM-MC]
NPO24089	Alcea rosea	Species	Malvaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TM-MC]
NPO17782	Inula britannica	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[TM-MC]
NPO12235	Trachelospermum jasminoides	Species	Apocynaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TM-MC]
NPO7132	Smilax glabra	Species	Smilacaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TM-MC]
NPO12181	Albizia julibrissin	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TM-MC]
NPO9124	Inula japonica	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[TM-MC]
NPO12796	Periploca sepium	Species	Apocynaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TM-MC]
NPO19472	Thymus vulgaris	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TM-MC]
NPO21072	Rhododendron dauricum	Species	Ericaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TM-MC]
NPO18007	Agrimonia pilosa	Species	Rosaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TM-MC]
NPO23205	Anthemis altissima	Species	n.a.	n.a.	n.a.	n.a.	n.a.	Database[UNPD]
NPO16831	Hypericum patulum	Species	Hypericaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO11083	Avrainvillea longicaulis	Species	Udoteaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO10325	Boletus pini	Species	Boletaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO3031	Sabal causiarum	Species	Arecaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO21409	Populus angustifolia	Species	Salicaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO8413	Echinus auritus	Species	Echinidae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO9357	Mitragyna inermis	Species	Rubiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO21187	Leucanthemopsis pallida	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO5383	Othonna dentata	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO11843	Stephania zippeliana	Species	Menispermaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO3075	Dimorphotheca aurantiaca	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO14054	Penicillium janczewskii	Species	Aspergillaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO2991	Duboisia leichhardtii	Species	Solanaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO6826	Persicaria perfoliata	Species	Polygonaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO526	Salvia sessei	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO18041	Cladrastis platycarpa	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO16725	Dalbergia hupeana	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO9888	Lobophytum laevigatum	Species	Alcyoniidae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO1337	Sphyraena japonica	Species	Sphyraenidae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO18925	Artemisia rehan	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO15742	Euphorbia laurifolia	Species	Euphorbiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO19010	Elephantopus hirtiflorus	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO1489	Pseudoplexaura flagellosa	Species	Plexauridae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO25479	Sabal blackburniana	Species	Arecaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO17894	Rhus vulgaris	Species	Anacardiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO11576	Glycosmis macrophylla	Species	Rutaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO12565	Hypericum polyanthemum	Species	Hypericaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO21276	Sedum forsteri	Species	Crassulaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO14012	Libanotis condensata	Species	Apiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO18345	Phora velutina	Species	Phoridae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO12935	Thymus quinquecostatus	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO16132	Bryum argenteum	Species	Bryaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO6731	Ononis spinosa	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO14704	Ephedra frustillata	Species	Ephedraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO4274	Alcyonium utinomii	Species	Alcyoniidae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO25181	Cyperus papyrus	Species	Cyperaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO17490	Trichophyton mentagrophytes	Species	Arthrodermataceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO8058	Pluchea odorata	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO4591	Neobellieria bullata	Species	Sarcophagidae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO13085	Islaya minor	n.a.	n.a.	n.a.	n.a.	n.a.	n.a.	Database[UNPD]
NPO13354	Euryspongia arenaria	Species	Dysideidae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO10309	Ichthyothere terminalis	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO1069	Meum athamanticum	Species	Apiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO15377	Calea clematidea	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO11780	Alpinia rafflesiana	Species	Zingiberaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO11190	Veronica polita	Species	Plantaginaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO15481	Hypericum balearicum	Species	Hypericaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO17698	Cirsium oligophyllum	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO2993	0totodarus sloanii	Species	Ommastrephidae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO22304	Morinda morindoides	Species	Rubiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO1390	Melolontha melolontha	Species	Scarabaeidae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO15121	Solanum habrochaites	Species	Solanaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO865	Dendrobium loddigesii	Species	Orchidaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO6062	Acacia mearnsii	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO18599	Pangium edule	Species	Achariaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO22636	Sterculia foetida	Species	Malvaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO17350	Jatropha macrorhiza	Species	Euphorbiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO24523	Senecio anteuphorbium	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO19168	Solidago flexicaulis	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO13884	Microglossa pyrrhopappa	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO16776	Euphorbia amygdaloides	Species	Euphorbiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO9532	Vernonia cistifolia	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO26559	Glycine soja	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO19055	Plenodomus tracheiphilus	Species	Leptosphaeriaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO25103	Stauranthus perforatus	n.a.	n.a.	n.a.	n.a.	n.a.	n.a.	Database[UNPD]
NPO6231	Cortinarius odoratus	Species	Cortinariaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO27467	Anigozanthos rufus	Species	Haemodoraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO12716	Stocksia brahuica	n.a.	n.a.	n.a.	n.a.	n.a.	n.a.	Database[UNPD]
NPO8080	Sarcophyton elegans	Species	Alcyoniidae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO26723	Lachnophyllum gossypinum	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO5975	Aspergillus carneus	Species	Aspergillaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO22691	Mentha cardiaca	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO8181	Hypoxylon tinctor	Species	Xylariaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO7822.1	Eucalyptus globulus subsp. bicostata	Subspecies	Myrtaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO26531	Aeschrion excelsa	n.a.	n.a.	n.a.	n.a.	n.a.	n.a.	Database[UNPD]
NPO10917	Junceella gemmacea	Species	Ellisellidae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO28952	Sapium haematospermum	Species	Euphorbiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO5261	Sideroxylon cubense	Species	Sapotaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO12929	Polianthes tuberosa	Species	Asparagaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO15487	Gymnopus confluens	Species	Omphalotaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO26378	Bistorta manshuriensis	Species	Polygonaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO21072	Rhododendron dauricum	Species	Ericaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO29152	Caloboletus calopus	Species	Boletaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO16978	Entada phaseoloides	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO21028	Sasa paniculata	Species	Poaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO16338	Virola calophylloidea	Species	Myristicaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO18260	Eremanthus seidelii	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO2295	Cydonia vulgaris	Species	Rosaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO12213	Perriera orientalis	Species	Simaroubaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO22329	Dolomedes okefinokensis	Species	Pisauridae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO16150	Nepeta argolica	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO18291	Idea leuconoe	Species	Nymphalidae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO2250	Hylocomium splendens	Species	Hylocomiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO19306	Cortinarius orellanus	Species	Cortinariaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO6289	Ceropegia dichotoma	Species	Apocynaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO22176	Lasiosiphon kraussianus	Species	Thymelaeaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO15838	Psorospermum molluscum	Species	Hypericaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO6380	Hydrocotyle vulgaris	Species	Araliaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO14173	Ipomoea reptans	Species	Convolvulaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO16574	Heywoodiella oligocephala	n.a.	n.a.	n.a.	n.a.	n.a.	n.a.	Database[UNPD]
NPO7550	Chromolaena arnottiana	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO26881	Croton zehntneri	Species	Euphorbiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO7132	Smilax glabra	Species	Smilacaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO19571	Oreopteris quelpaertensis	Species	Thelypteridaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO10163	Oreoherzogia fallax	Species	Rhamnaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO11747	Ocimum tenuiflorum	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO22434	Cryptosporium pinicola	n.a.	n.a.	n.a.	n.a.	n.a.	n.a.	Database[UNPD]
NPO17675	Andira inermis	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO14968	Mucuna membranacea	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO16537	Lonicera racemosa	Species	Caprifoliaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO8628	Strychnos erichsonii	Species	Loganiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO4949	Salvia yosgadensis	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO13204	Mallotus metcalfianus	Species	Euphorbiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO1402	Adenocarpus foliolosus	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO7540	Eucalyptus consideniana	Species	Myrtaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO4167	Oxalis repens	Species	Oxalidaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO12796	Periploca sepium	Species	Apocynaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO18422	Stizolobium deeringianum	n.a.	n.a.	n.a.	n.a.	n.a.	n.a.	Database[UNPD]
NPO9060	Sinularia granosa	Species	Alcyoniidae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO2697	Monodora tenuifolia	Species	Annonaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO12655	Tephrosia virginiana	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO6599	Neorautanenia ficifolia	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO11547	Lobelia cardinalis	Species	Campanulaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO26722	Dorstenia dinklagei	Species	Moraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO15779	Larix laricina	Species	Pinaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO26403	Brachymeris montana	n.a.	n.a.	n.a.	n.a.	n.a.	n.a.	Database[UNPD]
NPO1815	Breonia chinensis	Species	Rubiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO7760	Macrolepiota neomastoidea	Species	Agaricaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO28265	Morus alba	Species	Moraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO5456	Juniperus drupacea	Species	Cupressaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO21660	Magnolia montana	Species	Magnoliaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO10922	Pentaclethra macrophylla	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO3956	Maesa ramentacea	Species	Primulaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO14078	Paramecium tetraurelia	Species	Parameciidae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO9124	Inula japonica	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO12860	Clione antarctica	Species	Clionidae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO11975	Antillogorgia elisabethae	Species	Gorgoniidae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO10638	Plectranthus myrianthus	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO18993	Araiostegiella perdurans	Species	Davalliaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO15437	Aspergillus desertorum	Species	Aspergillaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO13484	Vidalia volubilis	Species	Tephritidae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO14715	Trollius chinensis	Species	Ranunculaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO422	Euphorbia cornigera	Species	Euphorbiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO15119	Aphis graminum	Species	Aphididae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO15786	Umbilicaria esculenta	Species	Umbilicariaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO13686	Lepraria lobificans	Species	Stereocaulaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO1242	Balanops australiana	Species	Balanopaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO27620.1	Pteris cretica var. nervosa	Varieties	Pteridaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO28450	Phyllanthus emblica	Species	Phyllanthaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO8934	Gypsophila perfoliata	Species	Caryophyllaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO6564	Betula exilis	Species	Betulaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO9319	Pterocaulon virgatum	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO12205	Eucalyptus apodophylla	Species	Myrtaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO29061	Anthoxanthum nitens	Species	Poaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO17222	Hesperis matronalis	Species	Brassicaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO13135	Campylotropis hirtella	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO22079	Paulownia tomentosa	Species	Paulowniaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO14167	Ambrosia artemisioides	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO25224	Maytenus retusa	Species	Celastraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO11409	Trichothecium sympodiale	Species	n.a.	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO19706	Polyzonium rosalbum	Species	Polyzoniidae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO26532	Gmelina asiatica	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO19631	Aphis pini	Species	Aphididae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO295	Kokoona reflexa	Species	Celastraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO29658	Spinulum annotinum	Species	Lycopodiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO17749	Jackiella javanica	Species	Jackiellaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO3743	Sideritis brevibracteata	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO24089	Alcea rosea	Species	Malvaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO15843	Dalbergia retusa	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO7606	Salacia lehmbachii	Species	Celastraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO16417	Elaeocarpus ganitrus	Species	Elaeocarpaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO25760	Aspergillus striatus	Species	Aspergillaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO26768	Lichtheimia blakesleeana	Species	Lichtheimiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO19832	Gambierdiscus toxicus	Species	Goniodomataceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO4793	Discoglossus pictus	Species	Alytidae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO5115	Abuta panurensis	Species	Menispermaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO17782	Inula britannica	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO13600	Ichthyothere latifolia	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO12235	Trachelospermum jasminoides	Species	Apocynaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO3648	Pittocaulon velatum	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO14346	Pterocarpus indica	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO14531	Dalbergia inundata	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO23907	Grazielia serrata	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO19240	Ligularia cymbulifera	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO12021	Artemisia incanescens	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO18672	Senecio adenophyllus	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO8288	Vitis cinerea	Species	Vitaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO3554	Aonidiella aurantii	Species	Diaspididae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO12181	Albizia julibrissin	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO20526	Menispermum dauricum	Species	Menispermaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO2725	Casuarina glauca	Species	Casuarinaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO13183	Cereus dumortieri	Species	Sagartiidae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO3873	Crotalaria candicans	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO2561	Capnella erecta	Species	Nephtheidae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO13726	Agrobacterium tumefaciens	Species	Rhizobiaceae	Bacteria	n.a.	n.a.	n.a.	Database[UNPD]
NPO13685	Scrophularia umbrosa	Species	Scrophulariaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO9704	Sonneratia caseolaris	Species	Lythraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO13841	Allium minutiflorum	Species	Amaryllidaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO3261	Aplysina archeri	Species	Aplysinidae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO13209	Strychnos tomentosa	Species	Loganiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO12564	Sinularia facile	Species	Alcyoniidae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO7449	Eleutherobia albiflora	Species	Alcyoniidae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO25611	Smilax china	Species	Smilacaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO12106	Aristeomorpha foliacea	Species	Aristeidae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO13502	Senecio algens	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO16316	Cylindrospermum muscicola	Species	0stocaceae	Bacteria	n.a.	n.a.	n.a.	Database[UNPD]
NPO14581	Rubia schumanniana	Species	Rubiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO21361	Anastatica hierochuntica	Species	Brassicaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO19086	Nematolepis phebalioides	Species	Rutaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO13987	Solanum sublobatum	Species	Solanaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO15615	Petunia hybrid	Species	Solanaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO5043	Eria japonica	Species	Orchidaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO19472	Thymus vulgaris	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO27951	Vigna mungo	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO5645	Silybum marianum	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO5584	Aldisa sanguinea	Species	Dorididae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO18007	Agrimonia pilosa	Species	Rosaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO15265	Paeonia rockii	Species	Paeoniaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO3247	Orchis fusca	Species	Orchidaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO24019	Sapindus emarginatus	Species	Sapindaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO14381	Swertia pseudochinensis	Species	Gentianaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO11508	Polygala reinii	Species	Polygalaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO7007	Eucalyptus jenseni	Species	Myrtaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO4499	Aglaia formosana	Species	Meliaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO16260	Stevia yaconensis	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO9017	Fagus grandifolia	Species	Fagaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO19370	Coprosma areolata	Species	Rubiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO6836	Alpinia blepharocalyx	Species	Zingiberaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO15232	Absidia repens	Species	Cunninghamellaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO16498	Adoxophyes orana	Species	Tortricidae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO2354	Rhizobium leguminosarum	Species	Rhizobiaceae	Bacteria	n.a.	n.a.	n.a.	Database[UNPD]
NPO11059	Callicarpa japonica	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO849	Euonymus tingens	Species	Celastraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO2687	Baphia bancoensis	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO14374	Retama duriaei	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO7773	Crinum moorei	Species	Amaryllidaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO9620	Rhodococcus fascians	Species	0cardiaceae	Bacteria	n.a.	n.a.	n.a.	Database[UNPD]
NPO13879	Humulus lupulus	Species	Cannabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO7342	Bostrychia scorpioides	Species	Rhodomelaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO3408	Viguiera decurrens	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO2408	Millettia laurentii	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO14834	Trachelospermum asiaticum	Species	Apocynaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO22798	Pseudofumaria lutea	Species	Papaveraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO25653	Spatholobus suberectus	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO376	Suillus tridentinus	Species	Suillaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO14249	Diplodia natalensis	Species	Botryosphaeriaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO13790	Abedus herberti	Species	Belostomatidae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO8308	Bryocaulon pseudosatoanum	Species	Parmeliaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO12091	Martensia denticulata	Species	Delesseriaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO23384	Rhodiola semenovii	Species	Crassulaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO13727	Hemionitis japonica	Species	Pteridaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO18839	Lilium umbellatum	Species	Liliaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO11036	Piper taboganum	Species	Piperaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO14214	Sedum obtuso-lineare	Species	Crassulaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO10605	Tristania conferta	Species	Myrtaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO18163	Aulosira fertilissima	Species	Fortieaceae	Bacteria	n.a.	n.a.	n.a.	Database[UNPD]
NPO4564	Anguilla japonica	Species	Anguillidae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO9540	Curvularia falcata	Species	Pleosporaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO21720	Talaromyces variabilis	Species	Trichocomaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO10741	Eucalyptus grossa	Species	Myrtaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO19766	Viguiera linearis	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO16053	Allium aflatunense	Species	Amaryllidaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO22285	Clethra macrophylla	Species	Clethraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO8842	Neurymenia fraxinifolia	Species	Rhodomelaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO17593	Pinus sylvestris	Species	Pinaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO1257	Distephanus angulifolius	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO13344	Helichrysum cephaloideum	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO6457	Pinus strobus	Species	Pinaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]

☑ Note for Reference:
In addition to directly collecting NP source organism data from primary literature (where reference will provided as NCBI PMID or DOI links), NPASS also integrated them from below databases:
☉ UNPD: Universal Natural Products Database [PMID: 23638153].
☉ StreptomeDB: a database of streptomycetes natural products [PMID: 33051671].
☉ TM-MC: a database of medicinal materials and chemical compounds in Northeast Asian traditional medicine [PMID: 26156871].
☉ TCM@Taiwan: a Traditional Chinese Medicine database [PMID: 21253603].
☉ TCMID: a Traditional Chinese Medicine database [PMID: 29106634].
☉ TCMSP: The traditional Chinese medicine systems pharmacology database and analysis platform [PMID: 24735618].
☉ HerDing: a herb recommendation system to treat diseases using genes and chemicals [PMID: 26980517].
☉ MetaboLights: a metabolomics database [PMID: 27010336].
☉ FooDB: a database of constituents, chemistry and biology of food species [www.foodb.ca].

NP Quantity Composition/Concentration

Organism ID	NP ID	Organism Material Preparation	Organism Part	NP Quantity (Standard)	NP Quantity (Minimum)	NP Quantity (Maximum)	Quantity Unit	Reference
NPO15265	NPC246162	n.a.	Fruits	0.42 ± 0.02	n.a.	n.a.	mg/100g of DW	PMID[33131958]
NPO15265	NPC246162	n.a.	Fruits	0.43 ± 0.02	n.a.	n.a.	mg/100g of DW	PMID[33131958]
NPO15265	NPC246162	n.a.	Fruits	0.46 ± 0.01	n.a.	n.a.	mg/100g of DW	PMID[33131958]
NPO15265	NPC246162	n.a.	Fruits	1.50 ± 0.06	n.a.	n.a.	mg/100g of DW	PMID[33131958]
NPO15265	NPC246162	n.a.	Fruits	1.22 ± 0.03	n.a.	n.a.	mg/100g of DW	PMID[33131958]
NPO15265	NPC246162	n.a.	Fruits	1.81 ± 0.05	n.a.	n.a.	mg/100g of DW	PMID[33131958]
NPO15265	NPC246162	n.a.	Fruits	0.91 ± 0.04	n.a.	n.a.	mg/100g of DW	PMID[33131958]
NPO15265	NPC246162	n.a.	Fruits	1.26 ± 0.02	n.a.	n.a.	mg/100g of DW	PMID[33131958]
NPO15265	NPC246162	n.a.	Fruits	0.93 ± 0.05	n.a.	n.a.	mg/100g of DW	PMID[33131958]
NPO15265	NPC246162	n.a.	Fruits	0.57 ± 0.01	n.a.	n.a.	mg/100g of DW	PMID[33131958]
NPO15265	NPC246162	n.a.	Seeds	1.59 ± 0.25	n.a.	n.a.	mg/100g of DW	PMID[33131958]
NPO15265	NPC246162	n.a.	Seeds	2.03 ± 0.02	n.a.	n.a.	mg/100g of DW	PMID[33131958]
NPO15265	NPC246162	n.a.	Seeds	2.92 ± 0.05	n.a.	n.a.	mg/100g of DW	PMID[33131958]
NPO15265	NPC246162	n.a.	Seeds	2.12 ± 0.03	n.a.	n.a.	mg/100g of DW	PMID[33131958]
NPO15265	NPC246162	n.a.	Seeds	1.24 ± 0.02	n.a.	n.a.	mg/100g of DW	PMID[33131958]
NPO15265	NPC246162	n.a.	Seeds	1.04 ± 0.03	n.a.	n.a.	mg/100g of DW	PMID[33131958]
NPO15265	NPC246162	n.a.	Seeds	0.75 ± 0.01	n.a.	n.a.	mg/100g of DW	PMID[33131958]
NPO15265	NPC246162	n.a.	Seeds	0.49 ± 0.01	n.a.	n.a.	mg/100g of DW	PMID[33131958]
NPO15265	NPC246162	n.a.	Seeds	0.39 ± 0.01	n.a.	n.a.	mg/100g of DW	PMID[33131958]
NPO15265	NPC246162	n.a.	Seeds	0.17 ± 0.01	n.a.	n.a.	mg/100g of DW	PMID[33131958]

☑ Note for Reference:
In addition to directly collecting NP quantitative data from primary literature (where reference will provided as NCBI PMID or DOI links), NPASS also integrated NP quantitative records for specific NP domains (e.g., NPS from foods or herbs) from domain-specific databases. These databases include:
☉ DUKE: Dr. Duke's Phytochemical and Ethnobotanical Databases.
☉ PHENOL EXPLORER: is the first comprehensive database on polyphenol content in foods [PMID: 24103452], its homepage can be accessed at here.
☉ FooDB: a database of constituents, chemistry and biology of food species [www.foodb.ca].

Biological Activity

Activity Type	# Activity
EC50	16
IC50	40
Kd	1
Ki	7
MIC	10
Others	131
Potency	17

Activity Type	# Activity
Cell Line	23
CELL-LINE	1
Individual Protein	60
NON-MOLECULAR	5
Organism	48
Others	76
Protein Family	1
Protein-Protein Interaction	1
SINGLE PROTEIN	7

Target ID	Target Type	Target Name	Target Organism	Activity Type	Activity Relation	Value	Unit	Reference
NPT459	Individual Protein	Human immunodeficiency virus type 1 reverse transcriptase	Human immunodeficiency virus 1	Inhibition	=	22.0	%	PMID[456562]
NPT1455	Individual Protein	P-glycoprotein 3	Mus musculus	Kd	=	37400.0	nM	PMID[456563]
NPT218	Individual Protein	Adenosine A3 receptor	Homo sapiens	pKi(uM)	=	-1.53	n.a.	PMID[456564]
NPT759	Cell Line	H9	Homo sapiens	IC50	=	9.8	ug.mL-1	PMID[456567]
NPT145	Individual Protein	Mu opioid receptor	Homo sapiens	Ke	=	3070.0	nM	PMID[456569]
NPT271	Individual Protein	Delta opioid receptor	Homo sapiens	Ke	=	3820.0	nM	PMID[456569]
NPT272	Individual Protein	Kappa opioid receptor	Homo sapiens	Ke	=	3280.0	nM	PMID[456569]
NPT1310	Individual Protein	Xanthine dehydrogenase	Bos taurus	Inhibition	=	17.8	%	PMID[456572]
NPT1460	Cell Line	L929	Mus musculus	EC50	=	200000.0	nM	PMID[456574]
NPT1460	Cell Line	L929	Mus musculus	EC50	=	240000.0	nM	PMID[456574]
NPT612	Individual Protein	Canalicular multispecific organic anion transporter 1	Homo sapiens	Activity	=	108.0	%	PMID[456577]
NPT25	Cell Line	MT4	Homo sapiens	CC50	=	25.4	ug.mL-1	PMID[456580]
NPT83	Cell Line	MCF7	Homo sapiens	EC50	>	10000.0	nM	PMID[456589]
NPT404	Cell Line	CCRF-CEM	Homo sapiens	EC50	>	10000.0	nM	PMID[456589]
NPT389	Cell Line	RPMI-8226	Homo sapiens	EC50	>	10000.0	nM	PMID[456589]
NPT2015	Cell Line	U-266	Homo sapiens	EC50	>	10000.0	nM	PMID[456589]
NPT165	Cell Line	HeLa	Homo sapiens	EC50	>	10000.0	nM	PMID[456589]
NPT1160	Cell Line	BJ	Homo sapiens	EC50	>	10000.0	nM	PMID[456589]
NPT1970	Cell Line	THP-1	Homo sapiens	EC50	>	10000.0	nM	PMID[456589]
NPT47	Individual Protein	ATP-dependent DNA helicase Q1	Homo sapiens	Potency	=	28183.8	nM	PMID[456590]
NPT48	Individual Protein	Lysine-specific demethylase 4D-like	Homo sapiens	Potency	=	19952.6	nM	PMID[456590]
NPT51	Individual Protein	Microtubule-associated protein tau	Homo sapiens	Potency	=	15848.9	nM	PMID[456590]
NPT3	Individual Protein	Thioredoxin glutathione reductase	Schistosoma mansoni	Potency	=	35481.3	nM	PMID[456590]
NPT56	Individual Protein	Beta-lactamase AmpC	Escherichia coli K-12	Potency	=	56234.1	nM	PMID[456590]
NPT59	Individual Protein	DNA polymerase beta	Homo sapiens	Potency	=	3162.3	nM	PMID[456590]
NPT60	Individual Protein	Lysosomal alpha-glucosidase	Homo sapiens	Potency	=	3548.1	nM	PMID[456590]
NPT4	Individual Protein	Large T antigen	Simian virus 40	IC50	n.a.	31960.0	nM	PMID[456591]
NPT5	Individual Protein	Histone-lysine N-methyltransferase, H3 lysine-9 specific 3	Homo sapiens	Potency	n.a.	10000.0	nM	PMID[456590]
NPT63	Individual Protein	Bromodomain adjacent to zinc finger domain protein 2B	Homo sapiens	Potency	n.a.	89125.1	nM	PMID[456590]
NPT199	Individual Protein	DNA polymerase kappa	Homo sapiens	Potency	n.a.	79432.8	nM	PMID[456594]
NPT568	Individual Protein	Matrix metalloproteinase-2	Homo sapiens	IC50	=	22620.0	nM	PMID[456595]
NPT567	Individual Protein	Matrix metalloproteinase 3	Homo sapiens	IC50	=	33910.0	nM	PMID[456595]
NPT280	Individual Protein	Matrix metalloproteinase 9	Homo sapiens	IC50	=	32020.0	nM	PMID[456595]
NPT1089	Individual Protein	Matrix metalloproteinase 12	Homo sapiens	IC50	=	5750.0	nM	PMID[456595]
NPT1090	Individual Protein	Matrix metalloproteinase 13	Homo sapiens	IC50	=	34600.0	nM	PMID[456595]
NPT568	Individual Protein	Matrix metalloproteinase-2	Homo sapiens	Inhibition	>	30.0	%	PMID[456595]
NPT567	Individual Protein	Matrix metalloproteinase 3	Homo sapiens	Inhibition	>	30.0	%	PMID[456595]
NPT280	Individual Protein	Matrix metalloproteinase 9	Homo sapiens	Inhibition	>	30.0	%	PMID[456595]
NPT1089	Individual Protein	Matrix metalloproteinase 12	Homo sapiens	Inhibition	>	30.0	%	PMID[456595]
NPT1090	Individual Protein	Matrix metalloproteinase 13	Homo sapiens	Inhibition	>	30.0	%	PMID[456595]
NPT10	Individual Protein	Geminin	Homo sapiens	Potency	n.a.	631.0	nM	PMID[456594]
NPT65	Cell Line	HepG2	Homo sapiens	Imax	=	43.4	%	PMID[456596]
NPT65	Cell Line	HepG2	Homo sapiens	Imax	=	40.1	%	PMID[456596]
NPT65	Cell Line	HepG2	Homo sapiens	Activity	>	200.0	uM	PMID[456596]
NPT65	Cell Line	HepG2	Homo sapiens	IC30	=	63.6	uM	PMID[456596]
NPT65	Cell Line	HepG2	Homo sapiens	IC30	=	40.0	uM	PMID[456596]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	Inhibition	=	17.81	%	PMID[456597]
NPT1650	Individual Protein	Tyrosine-protein kinase receptor FLT3	Homo sapiens	IC50	>	10000.0	nM	PMID[456600]
NPT1651	Individual Protein	Nuclear factor erythroid 2-related factor 2	Mus musculus	FC	=	1.0	n.a.	PMID[456601]
NPT1634	Individual Protein	Myeloperoxidase	Homo sapiens	Inhibition	=	40.0	%	PMID[456603]
NPT570	Individual Protein	Arachidonate 5-lipoxygenase	Homo sapiens	Inhibition	=	19.9	%	PMID[456604]
NPT535	Individual Protein	Parathyroid hormone receptor	Homo sapiens	Potency	n.a.	79432.8	nM	PMID[456594]
NPT49	Individual Protein	DNA-(apurinic or apyrimidinic site) lyase	Homo sapiens	Potency	n.a.	10000.0	nM	PMID[456590]
NPT441	Individual Protein	Cytochrome P450 19A1	Homo sapiens	Activity	=	90.7	%	PMID[456605]
NPT233	Individual Protein	Carbonic anhydrase II	Homo sapiens	Ki	>	10000.0	nM	PMID[456609]
NPT1062	Individual Protein	Carbonic anhydrase IV	Homo sapiens	Ki	=	9098.2	nM	PMID[456609]
NPT113	Cell Line	RAW264.7	Mus musculus	Inhibition	<	10.0	%	PMID[456611]
NPT1479	Individual Protein	Stem cell growth factor receptor	Homo sapiens	Activity	=	15.0	%	PMID[456615]
NPT1479	Individual Protein	Stem cell growth factor receptor	Homo sapiens	Activity	=	12.0	%	PMID[456615]
NPT1479	Individual Protein	Stem cell growth factor receptor	Homo sapiens	IC50	=	15700.0	nM	PMID[456615]
NPT1479	Individual Protein	Stem cell growth factor receptor	Homo sapiens	IC50	=	21900.0	nM	PMID[456615]
NPT71	Cell Line	HEK293	Homo sapiens	EC50	=	670660.0	nM	PMID[456618]
NPT71	Cell Line	HEK293	Homo sapiens	Ratio EC50	=	5.6	n.a.	PMID[456618]
NPT71	Cell Line	HEK293	Homo sapiens	Activity	=	22.65	%	PMID[456618]
NPT165	Cell Line	HeLa	Homo sapiens	EC50	=	125310.0	nM	PMID[456618]
NPT441	Individual Protein	Cytochrome P450 19A1	Homo sapiens	Inhibition	=	46.0	%	PMID[456621]
NPT441	Individual Protein	Cytochrome P450 19A1	Homo sapiens	Inhibition	=	56.0	%	PMID[456621]
NPT43	Individual Protein	Tyrosinase	Agaricus bisporus	KA	=	0.918	10'6L/mol	PMID[456622]
NPT43	Individual Protein	Tyrosinase	Agaricus bisporus	KSV	=	0.0492	10'4L/mol	PMID[456622]
NPT43	Individual Protein	Tyrosinase	Agaricus bisporus	Ki	=	34500.0	nM	PMID[456622]
NPT43	Individual Protein	Tyrosinase	Agaricus bisporus	IC50	=	27000.0	nM	PMID[456622]
NPT43	Individual Protein	Tyrosinase	Agaricus bisporus	Ki	=	8500.0	nM	PMID[456622]
NPT43	Individual Protein	Tyrosinase	Agaricus bisporus	IC50	=	23000.0	nM	PMID[456622]
NPT116	Cell Line	HL-60	Homo sapiens	IC50	=	0.01	ug.mL-1	PMID[456623]
NPT113	Cell Line	RAW264.7	Mus musculus	IC50	=	81600.0	nM	PMID[456629]
NPT2266	Individual Protein	Fructose-1,6-bisphosphatase	Homo sapiens	Inhibition	<	20.0	%	PMID[456630]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Inhibition	=	93.8	%	PMID[456561]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Inhibition	=	37.0	%	PMID[456561]
NPT24	Organism	Human immunodeficiency virus 1	Human immunodeficiency virus 1	IC50	=	45000.0	nM	PMID[456562]
NPT24	Organism	Human immunodeficiency virus 1	Human immunodeficiency virus 1	EC50	=	45000.0	nM	PMID[456562]
NPT27	Others	Unspecified		Therapeutic index	=	1.0	n.a.	PMID[456562]
NPT24	Organism	Human immunodeficiency virus 1	Human immunodeficiency virus 1	Inhibition	=	40.0	%	PMID[456562]
NPT2	Others	Unspecified		Delta Fmax	=	101.0	%	PMID[456563]
NPT316	Protein Family	Protein kinase C (PKC)	Homo sapiens	IC50	>	100000.0	nM	PMID[456565]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	0.0	%	PMID[456566]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	9.6	%	PMID[456566]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	11.7	%	PMID[456566]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	13.0	%	PMID[456566]
NPT24	Organism	Human immunodeficiency virus 1	Human immunodeficiency virus 1	EC50	=	9.8	ug.mL-1	PMID[456567]
NPT27	Others	Unspecified		Therapeutic index	=	1.0	n.a.	PMID[456567]
NPT2	Others	Unspecified		Ratio Ki	=	0.93	n.a.	PMID[456569]
NPT2	Others	Unspecified		Ratio Ki	=	1.2	n.a.	PMID[456569]
NPT1	Others	Radical scavenging activity		SC50	=	10.4	uM	PMID[456570]
NPT20529	NON-MOLECULAR	NON-PROTEIN TARGET	n.a.	IC50	=	1410.0	nM	PMID[456570]
NPT2	Others	Unspecified		IC50	=	1036.0	nM	PMID[456571]
NPT2	Others	Unspecified		IC50	=	300.0	ug.mL-1	PMID[456573]
NPT2567	Organism	Trichoderma viride	Hypocrea rufa	IZ	=	10.0	mm	PMID[456575]
NPT2	Others	Unspecified		Activity	=	41.0	n.a.	PMID[456576]
NPT2	Others	Unspecified		ID50	=	270.0	ug ml-1	PMID[456578]
NPT451	Organism	Helicobacter pylori	Helicobacter pylori	MIC	=	25.0	ug.mL-1	PMID[456579]
NPT20529	NON-MOLECULAR	NON-PROTEIN TARGET	n.a.	IC50	=	24200.0	nM	PMID[456580]
NPT610	Others	Molecular identity unknown		IC50	=	850300.0	nM	PMID[456580]
NPT1114	Organism	Human immunodeficiency virus	Human immunodeficiency virus	IC50	>	25.4	ug.mL-1	PMID[456580]
NPT2	Others	Unspecified		Ratio CC50/IC50	<	1.0	n.a.	PMID[456580]
NPT19	Organism	Escherichia coli	Escherichia coli	MIC	>	100.0	ug.mL-1	PMID[456580]
NPT19	Organism	Escherichia coli	Escherichia coli	MBC	>	100.0	ug ml-1	PMID[456580]
NPT18	Organism	Pseudomonas aeruginosa	Pseudomonas aeruginosa	MIC	>	100.0	ug.mL-1	PMID[456580]
NPT18	Organism	Pseudomonas aeruginosa	Pseudomonas aeruginosa	MBC	>	100.0	ug ml-1	PMID[456580]
NPT1398	Organism	Salmonella paratyphi	Salmonella enterica subsp. enterica serovar Paratyphi A	MIC	>	100.0	ug.mL-1	PMID[456580]
NPT1398	Organism	Salmonella paratyphi	Salmonella enterica subsp. enterica serovar Paratyphi A	MBC	>	100.0	ug ml-1	PMID[456580]
NPT1033	Organism	Enterobacter cloacae	Enterobacter cloacae	MIC	>	100.0	ug.mL-1	PMID[456580]
NPT1033	Organism	Enterobacter cloacae	Enterobacter cloacae	MBC	>	100.0	ug ml-1	PMID[456580]
NPT1176	Organism	Mycobacterium fortuitum	Mycobacterium fortuitum	MIC	>	100.0	ug.mL-1	PMID[456580]
NPT1176	Organism	Mycobacterium fortuitum	Mycobacterium fortuitum	MBC	>	100.0	ug ml-1	PMID[456580]
NPT16	Organism	Staphylococcus aureus	Staphylococcus aureus	MIC	>	100.0	ug.mL-1	PMID[456580]
NPT16	Organism	Staphylococcus aureus	Staphylococcus aureus	MBC	>	100.0	ug ml-1	PMID[456580]
NPT20	Organism	Candida albicans	Candida albicans	MIC	>	100.0	ug.mL-1	PMID[456580]
NPT20	Organism	Candida albicans	Candida albicans	MBC	>	100.0	ug ml-1	PMID[456580]
NPT2	Others	Unspecified		Activity	=	6.76	10'7/M	PMID[456581]
NPT175	Organism	Enterococcus faecalis	Enterococcus faecalis	MIC	=	128.0	ug.mL-1	PMID[456581]
NPT175	Organism	Enterococcus faecalis	Enterococcus faecalis	MIC	=	512.0	ug.mL-1	PMID[456581]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	1.42	umol/L	PMID[456582]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	3.88	ucat/L	PMID[456582]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	3.63	ucat/L	PMID[456582]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	11.31	ucat/L	PMID[456582]
NPT20529	NON-MOLECULAR	NON-PROTEIN TARGET	n.a.	Ratio	=	2.5	n.a.	PMID[456583]
NPT2	Others	Unspecified		IC50	=	154700.0	nM	PMID[456584]
NPT2	Others	Unspecified		Inhibition	=	3.5	%	PMID[456585]
NPT2	Others	Unspecified		Inhibition	=	3.1	%	PMID[456585]
NPT2	Others	Unspecified		Inhibition	=	6.7	%	PMID[456585]
NPT2	Others	Unspecified		Inhibition	=	21.7	%	PMID[456585]
NPT27	Others	Unspecified		Inhibition	<	8.8	%	PMID[456585]
NPT20529	NON-MOLECULAR	NON-PROTEIN TARGET	n.a.	Activity	=	1.9	MU	PMID[456586]
NPT35	Others	n.a.		Activity	=	213.5	mg/L	PMID[456586]
NPT2	Others	Unspecified		Inhibition	=	57.0	%	PMID[456587]
NPT2	Others	Unspecified		IC50	=	40100.0	nM	PMID[456587]
NPT2	Others	Unspecified		Inhibition	=	84.0	%	PMID[456587]
NPT2	Others	Unspecified		IC50	=	5900.0	nM	PMID[456591]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	57.0	%	PMID[456592]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	43.0	%	PMID[456592]
NPT533	Protein-Protein Interaction	Runt-related transcription factor 1/Core-binding factor subunit beta	Homo sapiens	Potency	n.a.	35481.3	nM	PMID[456590]
NPT1	Others	Radical scavenging activity		EC50	=	24.0	ug	PMID[456593]
NPT803	Individual Protein	Flap endonuclease 1	Homo sapiens	Potency	n.a.	31622.8	nM	PMID[456594]
NPT8	Individual Protein	DNA polymerase iota	Homo sapiens	Potency	n.a.	79432.8	nM	PMID[456594]
NPT2	Others	Unspecified		Potency	n.a.	562.3	nM	PMID[456594]
NPT2	Others	Unspecified		Activity	=	0.99	mM	PMID[456596]
NPT2	Others	Unspecified		Activity	=	0.248	V	PMID[456596]
NPT67	Individual Protein	Cholinesterase	Equus caballus	Inhibition	=	0.97	%	PMID[456597]
NPT1	Others	Radical scavenging activity		Inhibition	=	94.8	%	PMID[456598]
NPT2	Others	Unspecified		IC50	=	12000.0	nM	PMID[456599]
NPT2	Others	Unspecified		Inhibition	=	50.0	%	PMID[456603]
NPT2	Others	Unspecified		IC50	=	15300.0	nM	PMID[456603]
NPT2	Others	Unspecified		IC50	=	41300.0	nM	PMID[456603]
NPT2	Others	Unspecified		IC50	=	15500.0	nM	PMID[456603]
NPT2	Others	Unspecified		IC50	=	53500.0	nM	PMID[456603]
NPT27	Others	Unspecified		Activity	>	98.0	%	PMID[456603]
NPT2	Others	Unspecified		Activity	=	500.0	uM	PMID[456607]
NPT2	Others	Unspecified		FC	=	1.9	n.a.	PMID[456607]
NPT2	Others	Unspecified		Activity	=	12.0	%	PMID[456607]
NPT2	Others	Unspecified		Activity	=	29.0	%	PMID[456607]
NPT2	Others	Unspecified		Activity	=	59.0	%	PMID[456607]
NPT2	Others	Unspecified		FC	=	1.4	n.a.	PMID[456607]
NPT20529	NON-MOLECULAR	NON-PROTEIN TARGET	n.a.	FC	=	3.1	n.a.	PMID[456607]
NPT2	Others	Unspecified		FC	=	1.6	n.a.	PMID[456607]
NPT35	Others	n.a.		EC50	=	11300.0	nM	PMID[456608]
NPT35	Others	n.a.		Activity	=	2.84	mmolequiv/mmol	PMID[456608]
NPT35	Others	n.a.		Activity	=	2.48	mmolequiv/mmol	PMID[456608]
NPT35	Others	n.a.		Activity	=	9.3	mmolequiv/mmol	PMID[456608]
NPT35	Others	n.a.		Activity	=	6.61	mmolequiv/mmol	PMID[456608]
NPT947	Individual Protein	Carbonic anhydrase I	Homo sapiens	Ki	>	10000.0	nM	PMID[456609]
NPT955	Individual Protein	Carbonic anhydrase VII	Homo sapiens	Ki	=	493.1	nM	PMID[456609]
NPT949	Individual Protein	Carbonic anhydrase XII	Homo sapiens	Ki	=	32.5	nM	PMID[456609]
NPT2	Others	Unspecified		IC50	=	9300.0	nM	PMID[456610]
NPT2	Others	Unspecified		IC50	=	34200.0	nM	PMID[456610]
NPT35	Others	n.a.		EC50	=	13900.0	nM	PMID[456611]
NPT27	Others	Unspecified		Activity	=	103.0	%	PMID[456612]
NPT27	Others	Unspecified		Activity	=	101.0	%	PMID[456612]
NPT27	Others	Unspecified		Activity	=	102.0	%	PMID[456612]
NPT27	Others	Unspecified		Activity	=	92.0	%	PMID[456612]
NPT27	Others	Unspecified		Activity	=	98.0	%	PMID[456612]
NPT78	Individual Protein	Beta amyloid A4 protein	Homo sapiens	IC50	=	33000.0	nM	PMID[456614]
NPT2	Others	Unspecified		IC50	=	153.1	ug.mL-1	PMID[456616]
NPT22036	CELL-LINE	HL	Homo sapiens	Activity	=	95.2	%	PMID[456617]
NPT5310	Organism	Chlamydophila pneumoniae	Chlamydophila pneumoniae	Inhibition	=	13.4	%	PMID[456617]
NPT35	Others	n.a.		Drug degradation	=	10.09	%	PMID[456618]
NPT35	Others	n.a.		Drug degradation	=	43.41	%	PMID[456618]
NPT35	Others	n.a.		Solubility	=	1200.0	ug.mL-1	PMID[456618]
NPT35	Others	n.a.		Activity	=	13.8	%	PMID[456618]
NPT35	Others	n.a.		Activity	=	88.74	%	PMID[456618]
NPT35	Others	n.a.		IC50	=	34000.0	nM	PMID[456618]
NPT35	Others	n.a.		Activity	=	84.92	%	PMID[456618]
NPT35	Others	n.a.		IC50	=	48000.0	nM	PMID[456618]
NPT35	Others	n.a.		IC50	=	500.0	ug.mL-1	PMID[456618]
NPT35	Others	n.a.		Solubility	=	20.0	ug.mL-1	PMID[456618]
NPT20555	ORGANISM	SARS-CoV-2	Severe acute respiratory syndrome coronavirus 2	Inhibition	=	-7.24	%	PMID[456620]
NPT20556	SINGLE PROTEIN	Replicase polyprotein 1ab	Severe acute respiratory syndrome coronavirus 2	Inhibition	=	-4.46	%	PMID[456624]
NPT20556	SINGLE PROTEIN	Replicase polyprotein 1ab	Severe acute respiratory syndrome coronavirus 2	Inhibition	=	24.64	%	PMID[456625]
NPT20555	ORGANISM	SARS-CoV-2	Severe acute respiratory syndrome coronavirus 2	Inhibition	=	-0.13	%	PMID[456626]
NPT20555	ORGANISM	SARS-CoV-2	Severe acute respiratory syndrome coronavirus 2	Inhibition	=	-0.01	%	PMID[456627]
NPT20	Organism	Candida albicans	Candida albicans	Inhibition	=	3.72	%	PMID[456628]
NPT85	Organism	Filobasidiella neoformans	Cryptococcus neoformans	Inhibition	=	-3.68	%	PMID[456628]
NPT19	Organism	Escherichia coli	Escherichia coli	Inhibition	=	-0.85	%	PMID[456628]
NPT173	Organism	Klebsiella pneumoniae	Klebsiella pneumoniae	Inhibition	=	12.56	%	PMID[456628]
NPT18	Organism	Pseudomonas aeruginosa	Pseudomonas aeruginosa	Inhibition	=	12.91	%	PMID[456628]
NPT747	Organism	Acinetobacter baumannii	Acinetobacter baumannii	Inhibition	=	8.51	%	PMID[456628]
NPT2922	Organism	Staphylococcus aureus subsp. aureus	Staphylococcus aureus subsp. aureus	Inhibition	=	8.9	%	PMID[456628]
NPT2	Others	Unspecified		IC50	=	4000000.0	nM	PMID[456631]
NPT2	Others	Unspecified		IC50	=	50000.0	nM	PMID[456632]
NPT22917	SINGLE PROTEIN	Cytochrome c	Homo sapiens	Inhibition	=	58.0	%	PMID[456633]
NPT22917	SINGLE PROTEIN	Cytochrome c	Homo sapiens	Inhibition	=	67.0	%	PMID[456633]
NPT22917	SINGLE PROTEIN	Cytochrome c	Homo sapiens	Inhibition	=	36.0	%	PMID[456633]
NPT22917	SINGLE PROTEIN	Cytochrome c	Homo sapiens	K	=	1.0	/M/s	PMID[456633]
NPT22917	SINGLE PROTEIN	Cytochrome c	Homo sapiens	K	=	0.067	/min	PMID[456633]
NPT27	Others	Unspecified		log Pe	=	-6.91	n.a.	PMID[456633]
NPT35	Others	n.a.		LogD	=	0.67	n.a.	PMID[456633]

☑ Note for Activity Records:
☉ The quantitative biological activities were primarily integrated from ChEMBL (Version-30) database and were also directly collected from PubMed literature. PubMed PMID was provided as the reference link for each activity record.

Chemically structural similarity: I. Similar Active Natural Products in NPASS

Top-200 similar NPs were calculated against the active-NP-set (includes 4,3285 NPs with experimentally-derived bioactivity available in NPASS)

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules. Tc lies between [0, 1] where '1' indicates the highest similarity. What is Tanimoto coefficient

● The left chart: Distribution of similarity level between NPC246162 and all remaining natural products in the NPASS database.
● The right table: Most similar natural products (Tc>=0.56 or Top200).

range	Tanimoto Coefficient
0-0.1	458
0.1-0.2	1766
0.2-0.3	4623
0.3-0.4	10685
0.4-0.5	6885
0.5-0.6	3638
0.6-0.7	4802
0.7-0.8	5415
0.8-0.85	2627
0.85-0.9	1369
0.9-0.95	374
0.95-1	55

Similarity Score	Similarity Level	Natural Product ID
1.0	High Similarity	NPC9743
1.0	High Similarity	NPC260491
1.0	High Similarity	NPC36835
1.0	High Similarity	NPC61506
1.0	High Similarity	NPC240476
0.9932	High Similarity	NPC256346
0.9932	High Similarity	NPC246328
0.9932	High Similarity	NPC27532
0.9932	High Similarity	NPC325028
0.9863	High Similarity	NPC19721
0.9797	High Similarity	NPC326037
0.9797	High Similarity	NPC13858
0.9797	High Similarity	NPC320825
0.9797	High Similarity	NPC201837
0.9732	High Similarity	NPC52530
0.9724	High Similarity	NPC294852
0.9724	High Similarity	NPC188679
0.9724	High Similarity	NPC321011
0.9724	High Similarity	NPC218569
0.9667	High Similarity	NPC22192
0.9664	High Similarity	NPC471500
0.9664	High Similarity	NPC250922
0.9662	High Similarity	NPC141212
0.9658	High Similarity	NPC1612
0.9658	High Similarity	NPC183959
0.9655	High Similarity	NPC21835
0.9603	High Similarity	NPC263449
0.9603	High Similarity	NPC287328
0.9603	High Similarity	NPC282009
0.9603	High Similarity	NPC470183
0.96	High Similarity	NPC471515
0.96	High Similarity	NPC471479
0.9595	High Similarity	NPC236637
0.9595	High Similarity	NPC302950
0.9595	High Similarity	NPC219582
0.9539	High Similarity	NPC308992
0.9539	High Similarity	NPC471499
0.9539	High Similarity	NPC289771
0.9533	High Similarity	NPC474638
0.953	High Similarity	NPC18727
0.9527	High Similarity	NPC204515
0.9517	High Similarity	NPC142731
0.9517	High Similarity	NPC279417
0.9517	High Similarity	NPC326506
0.9517	High Similarity	NPC49130
0.9517	High Similarity	NPC4152
0.9517	High Similarity	NPC306607
0.9517	High Similarity	NPC62290
0.9517	High Similarity	NPC208176
0.9474	High Similarity	NPC471744
0.9474	High Similarity	NPC470326
0.947	High Similarity	NPC474055
0.947	High Similarity	NPC472598
0.947	High Similarity	NPC67876
0.9467	High Similarity	NPC321779
0.9456	High Similarity	NPC3036
0.9456	High Similarity	NPC119059
0.9452	High Similarity	NPC1940
0.9452	High Similarity	NPC20791
0.9452	High Similarity	NPC179271
0.9452	High Similarity	NPC148011
0.9416	High Similarity	NPC472625
0.9412	High Similarity	NPC112418
0.9412	High Similarity	NPC173137
0.9408	High Similarity	NPC53545
0.9408	High Similarity	NPC55738
0.9408	High Similarity	NPC117418
0.9404	High Similarity	NPC255106
0.9404	High Similarity	NPC291878
0.9404	High Similarity	NPC35038
0.9404	High Similarity	NPC195796
0.9404	High Similarity	NPC278778
0.9404	High Similarity	NPC235165
0.94	High Similarity	NPC192083
0.94	High Similarity	NPC213896
0.9396	High Similarity	NPC125062
0.9396	High Similarity	NPC252933
0.9396	High Similarity	NPC54394
0.9396	High Similarity	NPC200740
0.9392	High Similarity	NPC105512
0.9392	High Similarity	NPC270465
0.9392	High Similarity	NPC87125
0.9388	High Similarity	NPC176869
0.9388	High Similarity	NPC95864
0.9388	High Similarity	NPC3779
0.9388	High Similarity	NPC44721
0.9388	High Similarity	NPC40086
0.9388	High Similarity	NPC476182
0.9388	High Similarity	NPC211466
0.9388	High Similarity	NPC74881
0.9388	High Similarity	NPC51443
0.9388	High Similarity	NPC122828
0.9355	High Similarity	NPC7688
0.9355	High Similarity	NPC72787
0.9355	High Similarity	NPC58223
0.9355	High Similarity	NPC7154
0.9355	High Similarity	NPC36916
0.9355	High Similarity	NPC36
0.9355	High Similarity	NPC125039
0.9351	High Similarity	NPC471745
0.9351	High Similarity	NPC211107
0.9342	High Similarity	NPC99597
0.9342	High Similarity	NPC162869
0.9342	High Similarity	NPC27337
0.9342	High Similarity	NPC156057
0.9342	High Similarity	NPC210084
0.9342	High Similarity	NPC475267
0.9342	High Similarity	NPC474208
0.9342	High Similarity	NPC48208
0.9342	High Similarity	NPC291508
0.9342	High Similarity	NPC474836
0.9338	High Similarity	NPC477503
0.9338	High Similarity	NPC470327
0.9338	High Similarity	NPC45849
0.9338	High Similarity	NPC200761
0.9338	High Similarity	NPC67396
0.9333	High Similarity	NPC199100
0.9333	High Similarity	NPC279989
0.9333	High Similarity	NPC55205
0.9333	High Similarity	NPC180234
0.9333	High Similarity	NPC472912
0.9333	High Similarity	NPC260979
0.9333	High Similarity	NPC106976
0.9333	High Similarity	NPC120537
0.9333	High Similarity	NPC82325
0.9329	High Similarity	NPC188871
0.9329	High Similarity	NPC61620
0.9329	High Similarity	NPC62042
0.9329	High Similarity	NPC338131
0.9329	High Similarity	NPC149127
0.9329	High Similarity	NPC29231
0.9329	High Similarity	NPC286342
0.9324	High Similarity	NPC272721
0.9324	High Similarity	NPC43669
0.9324	High Similarity	NPC196277
0.9324	High Similarity	NPC276930
0.932	High Similarity	NPC169749
0.9315	High Similarity	NPC279121
0.9295	High Similarity	NPC471213
0.9286	High Similarity	NPC474038
0.9286	High Similarity	NPC472632
0.9286	High Similarity	NPC472634
0.9286	High Similarity	NPC26326
0.9286	High Similarity	NPC142252
0.9286	High Similarity	NPC158188
0.9281	High Similarity	NPC152904
0.9276	High Similarity	NPC470328
0.9276	High Similarity	NPC209614
0.9276	High Similarity	NPC24640
0.9276	High Similarity	NPC472626
0.9272	High Similarity	NPC179126
0.9272	High Similarity	NPC469550
0.9272	High Similarity	NPC270620
0.9272	High Similarity	NPC88645
0.9272	High Similarity	NPC298692
0.9272	High Similarity	NPC78326
0.9272	High Similarity	NPC167091
0.9272	High Similarity	NPC236223
0.9272	High Similarity	NPC292214
0.9272	High Similarity	NPC74924
0.9272	High Similarity	NPC206238
0.9272	High Similarity	NPC271779
0.9267	High Similarity	NPC262039
0.9267	High Similarity	NPC262038
0.9267	High Similarity	NPC251110
0.9267	High Similarity	NPC254412
0.9267	High Similarity	NPC28274
0.9267	High Similarity	NPC50403
0.9267	High Similarity	NPC260895
0.9267	High Similarity	NPC278476
0.9267	High Similarity	NPC31363
0.9267	High Similarity	NPC225731
0.9267	High Similarity	NPC133953
0.9267	High Similarity	NPC319910
0.9262	High Similarity	NPC223579
0.9262	High Similarity	NPC287101
0.9262	High Similarity	NPC183950
0.9262	High Similarity	NPC137062
0.9262	High Similarity	NPC159103
0.9262	High Similarity	NPC52005
0.9262	High Similarity	NPC195351
0.9257	High Similarity	NPC108406
0.9257	High Similarity	NPC77378
0.9252	High Similarity	NPC70136
0.9247	High Similarity	NPC175013
0.9241	High Similarity	NPC182421
0.9236	High Similarity	NPC42892
0.9236	High Similarity	NPC160156
0.9236	High Similarity	NPC92565
0.9236	High Similarity	NPC260266
0.9231	High Similarity	NPC277205
0.9231	High Similarity	NPC224280
0.9231	High Similarity	NPC62261
0.9231	High Similarity	NPC475888
0.9226	High Similarity	NPC127782
0.9226	High Similarity	NPC472635
0.9226	High Similarity	NPC300537
0.9226	High Similarity	NPC472964
0.9226	High Similarity	NPC474033
0.9226	High Similarity	NPC476247

Chemically structural similarity: II. Similar Clinical/Approved Drugs

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules.

● The left chart: Distribution of similarity level between NPC246162 and all drugs/candidates.
● The right table: Most similar clinical/approved drugs (Tc>=0.56 or Top200).

range	Tanimoto Coefficient
0-0.1	435
0.1-0.2	924
0.2-0.3	1904
0.3-0.4	2567
0.4-0.5	1724
0.5-0.6	955
0.6-0.7	464
0.7-0.8	121
0.8-0.85	33
0.85-0.9	12
0.9-0.95	10
0.95-1	1

Similarity Score	Similarity Level	Drug ID	Developmental Stage
0.9595	High Similarity	NPD1934	Approved
0.9452	High Similarity	NPD1512	Approved
0.94	High Similarity	NPD2393	Clinical (unspecified phase)
0.9355	High Similarity	NPD6167	Clinical (unspecified phase)
0.9355	High Similarity	NPD6166	Phase 2
0.9355	High Similarity	NPD6168	Clinical (unspecified phase)
0.9315	High Similarity	NPD1511	Approved
0.9034	High Similarity	NPD1552	Clinical (unspecified phase)
0.9034	High Similarity	NPD1550	Clinical (unspecified phase)
0.9026	High Similarity	NPD3882	Suspended
0.902	High Similarity	NPD2801	Approved
0.8973	High Similarity	NPD1549	Phase 2
0.8944	High Similarity	NPD6797	Phase 2
0.8889	High Similarity	NPD7251	Discontinued
0.8882	High Similarity	NPD7074	Phase 3
0.8875	High Similarity	NPD3818	Discontinued
0.8839	High Similarity	NPD3817	Phase 2
0.8834	High Similarity	NPD4338	Clinical (unspecified phase)
0.8824	High Similarity	NPD4380	Phase 2
0.882	High Similarity	NPD7054	Approved
0.8782	High Similarity	NPD4868	Clinical (unspecified phase)
0.8765	High Similarity	NPD7472	Approved
0.8742	High Similarity	NPD4378	Clinical (unspecified phase)
0.8726	High Similarity	NPD4381	Clinical (unspecified phase)
0.8726	High Similarity	NPD7075	Discontinued
0.872	High Similarity	NPD7808	Phase 3
0.8654	High Similarity	NPD7096	Clinical (unspecified phase)
0.8639	High Similarity	NPD1510	Phase 2
0.8621	High Similarity	NPD1612	Clinical (unspecified phase)
0.8621	High Similarity	NPD1613	Approved
0.8598	High Similarity	NPD7993	Clinical (unspecified phase)
0.8476	Intermediate Similarity	NPD7804	Clinical (unspecified phase)
0.8471	Intermediate Similarity	NPD6801	Discontinued
0.8431	Intermediate Similarity	NPD6799	Approved
0.8385	Intermediate Similarity	NPD5494	Approved
0.8367	Intermediate Similarity	NPD943	Approved
0.8367	Intermediate Similarity	NPD1240	Approved
0.8365	Intermediate Similarity	NPD5402	Approved
0.8345	Intermediate Similarity	NPD1529	Clinical (unspecified phase)
0.8333	Intermediate Similarity	NPD2796	Approved
0.8302	Intermediate Similarity	NPD1465	Phase 2
0.8276	Intermediate Similarity	NPD1530	Clinical (unspecified phase)
0.8269	Intermediate Similarity	NPD5403	Approved
0.8258	Intermediate Similarity	NPD5401	Approved
0.8255	Intermediate Similarity	NPD1607	Approved
0.825	Intermediate Similarity	NPD8443	Clinical (unspecified phase)
0.8228	Intermediate Similarity	NPD6599	Discontinued
0.8187	Intermediate Similarity	NPD7819	Suspended
0.8144	Intermediate Similarity	NPD5844	Phase 1
0.811	Intermediate Similarity	NPD1247	Approved
0.811	Intermediate Similarity	NPD6959	Discontinued
0.8107	Intermediate Similarity	NPD6559	Discontinued
0.8098	Intermediate Similarity	NPD919	Approved
0.8063	Intermediate Similarity	NPD7411	Suspended
0.8061	Intermediate Similarity	NPD6232	Discontinued
0.8026	Intermediate Similarity	NPD651	Clinical (unspecified phase)
0.8025	Intermediate Similarity	NPD7410	Clinical (unspecified phase)
0.8024	Intermediate Similarity	NPD7473	Discontinued
0.7987	Intermediate Similarity	NPD970	Clinical (unspecified phase)
0.7976	Intermediate Similarity	NPD3751	Discontinued
0.7974	Intermediate Similarity	NPD1551	Phase 2
0.7947	Intermediate Similarity	NPD230	Phase 1
0.7919	Intermediate Similarity	NPD3027	Phase 3
0.7904	Intermediate Similarity	NPD3926	Phase 2
0.7885	Intermediate Similarity	NPD3750	Approved
0.7844	Intermediate Similarity	NPD3787	Discontinued
0.7834	Intermediate Similarity	NPD6190	Approved
0.7818	Intermediate Similarity	NPD3749	Approved
0.7771	Intermediate Similarity	NPD4628	Phase 3
0.7764	Intermediate Similarity	NPD1653	Approved
0.7751	Intermediate Similarity	NPD7852	Clinical (unspecified phase)
0.774	Intermediate Similarity	NPD1547	Clinical (unspecified phase)
0.7712	Intermediate Similarity	NPD447	Suspended
0.7707	Intermediate Similarity	NPD2800	Approved
0.7651	Intermediate Similarity	NPD7768	Phase 2
0.7632	Intermediate Similarity	NPD6859	Clinical (unspecified phase)
0.7628	Intermediate Similarity	NPD2935	Discontinued
0.7619	Intermediate Similarity	NPD1610	Phase 2
0.7598	Intermediate Similarity	NPD7879	Clinical (unspecified phase)
0.7595	Intermediate Similarity	NPD7421	Clinical (unspecified phase)
0.7593	Intermediate Similarity	NPD920	Approved
0.7593	Intermediate Similarity	NPD6980	Clinical (unspecified phase)
0.7588	Intermediate Similarity	NPD7184	Clinical (unspecified phase)
0.7578	Intermediate Similarity	NPD2533	Approved
0.7578	Intermediate Similarity	NPD2534	Approved
0.7578	Intermediate Similarity	NPD642	Clinical (unspecified phase)
0.7578	Intermediate Similarity	NPD2532	Approved
0.7574	Intermediate Similarity	NPD7199	Phase 2
0.7564	Intermediate Similarity	NPD3748	Approved
0.7562	Intermediate Similarity	NPD643	Clinical (unspecified phase)
0.755	Intermediate Similarity	NPD9494	Approved
0.7547	Intermediate Similarity	NPD1878	Clinical (unspecified phase)
0.7533	Intermediate Similarity	NPD1203	Approved
0.7516	Intermediate Similarity	NPD6099	Approved
0.7516	Intermediate Similarity	NPD6100	Approved
0.7514	Intermediate Similarity	NPD8055	Clinical (unspecified phase)
0.7484	Intermediate Similarity	NPD1243	Approved
0.7484	Intermediate Similarity	NPD1933	Approved
0.7469	Intermediate Similarity	NPD7004	Clinical (unspecified phase)
0.7468	Intermediate Similarity	NPD2344	Approved
0.7466	Intermediate Similarity	NPD1548	Phase 1
0.7456	Intermediate Similarity	NPD6234	Discontinued
0.7452	Intermediate Similarity	NPD1509	Clinical (unspecified phase)
0.7443	Intermediate Similarity	NPD4419	Clinical (unspecified phase)
0.7432	Intermediate Similarity	NPD8090	Clinical (unspecified phase)
0.7407	Intermediate Similarity	NPD6143	Clinical (unspecified phase)
0.7405	Intermediate Similarity	NPD7501	Clinical (unspecified phase)
0.7403	Intermediate Similarity	NPD6798	Discontinued
0.7403	Intermediate Similarity	NPD2313	Discontinued
0.7401	Intermediate Similarity	NPD8312	Approved
0.7401	Intermediate Similarity	NPD8313	Approved
0.7394	Intermediate Similarity	NPD3226	Approved
0.7389	Intermediate Similarity	NPD8397	Clinical (unspecified phase)
0.7386	Intermediate Similarity	NPD4908	Phase 1
0.7374	Intermediate Similarity	NPD8434	Phase 2
0.7365	Intermediate Similarity	NPD37	Approved
0.7358	Intermediate Similarity	NPD2346	Discontinued
0.7356	Intermediate Similarity	NPD7228	Approved
0.7342	Intermediate Similarity	NPD7033	Discontinued
0.7337	Intermediate Similarity	NPD4967	Phase 2
0.7337	Intermediate Similarity	NPD4965	Approved
0.7337	Intermediate Similarity	NPD4966	Approved
0.7333	Intermediate Similarity	NPD9269	Phase 2
0.733	Intermediate Similarity	NPD5953	Discontinued
0.7325	Intermediate Similarity	NPD6651	Approved
0.7322	Intermediate Similarity	NPD4360	Phase 2
0.7322	Intermediate Similarity	NPD4363	Phase 3
0.7314	Intermediate Similarity	NPD7286	Phase 2
0.7312	Intermediate Similarity	NPD6780	Approved
0.7312	Intermediate Similarity	NPD6777	Approved
0.7312	Intermediate Similarity	NPD6776	Approved
0.7312	Intermediate Similarity	NPD6779	Approved
0.7312	Intermediate Similarity	NPD6778	Approved
0.7312	Intermediate Similarity	NPD6781	Approved
0.7312	Intermediate Similarity	NPD6782	Approved
0.729	Intermediate Similarity	NPD4907	Clinical (unspecified phase)
0.7288	Intermediate Similarity	NPD7685	Pre-registration
0.7285	Intermediate Similarity	NPD4379	Clinical (unspecified phase)
0.7284	Intermediate Similarity	NPD2309	Approved
0.7278	Intermediate Similarity	NPD8150	Discontinued
0.7267	Intermediate Similarity	NPD1652	Phase 2
0.7261	Intermediate Similarity	NPD1899	Clinical (unspecified phase)
0.7261	Intermediate Similarity	NPD6355	Discontinued
0.7244	Intermediate Similarity	NPD6233	Phase 2
0.7233	Intermediate Similarity	NPD2799	Discontinued
0.7222	Intermediate Similarity	NPD6398	Clinical (unspecified phase)
0.7219	Intermediate Similarity	NPD1608	Approved
0.7219	Intermediate Similarity	NPD9717	Approved
0.7208	Intermediate Similarity	NPD2861	Phase 2
0.7196	Intermediate Similarity	NPD7435	Discontinued
0.7195	Intermediate Similarity	NPD7390	Discontinued
0.7186	Intermediate Similarity	NPD5808	Clinical (unspecified phase)
0.7173	Intermediate Similarity	NPD7584	Approved
0.7161	Intermediate Similarity	NPD6832	Phase 2
0.716	Intermediate Similarity	NPD6844	Discontinued
0.7152	Intermediate Similarity	NPD1201	Approved
0.7152	Intermediate Similarity	NPD422	Phase 1
0.7143	Intermediate Similarity	NPD2403	Approved
0.7143	Intermediate Similarity	NPD7266	Discontinued
0.7126	Intermediate Similarity	NPD5710	Approved
0.7126	Intermediate Similarity	NPD5711	Approved
0.7118	Intermediate Similarity	NPD8455	Phase 2
0.7105	Intermediate Similarity	NPD7697	Approved
0.7105	Intermediate Similarity	NPD7696	Phase 3
0.7105	Intermediate Similarity	NPD7698	Approved
0.7101	Intermediate Similarity	NPD7615	Clinical (unspecified phase)
0.7099	Intermediate Similarity	NPD2424	Discontinued
0.7098	Intermediate Similarity	NPD8151	Discontinued
0.7089	Intermediate Similarity	NPD4060	Phase 1
0.7086	Intermediate Similarity	NPD5242	Approved
0.7078	Intermediate Similarity	NPD1470	Approved
0.7076	Intermediate Similarity	NPD5353	Approved
0.7073	Intermediate Similarity	NPD2354	Approved
0.707	Intermediate Similarity	NPD3268	Approved
0.707	Intermediate Similarity	NPD411	Approved
0.7068	Intermediate Similarity	NPD7871	Phase 2
0.7068	Intermediate Similarity	NPD7870	Phase 2
0.7067	Intermediate Similarity	NPD9268	Approved
0.7062	Intermediate Similarity	NPD2163	Approved
0.7048	Intermediate Similarity	NPD7422	Clinical (unspecified phase)
0.7048	Intermediate Similarity	NPD4661	Approved
0.7048	Intermediate Similarity	NPD4662	Approved
0.7047	Intermediate Similarity	NPD7701	Phase 2
0.7045	Intermediate Similarity	NPD7784	Clinical (unspecified phase)
0.7044	Intermediate Similarity	NPD5123	Clinical (unspecified phase)
0.7044	Intermediate Similarity	NPD5124	Phase 1
0.7043	Intermediate Similarity	NPD6534	Approved
0.7043	Intermediate Similarity	NPD6535	Approved
0.7039	Intermediate Similarity	NPD1091	Approved
0.7037	Intermediate Similarity	NPD1471	Phase 3
0.7032	Intermediate Similarity	NPD2798	Approved
0.702	Intermediate Similarity	NPD17	Approved
0.7019	Intermediate Similarity	NPD4308	Phase 3
0.7013	Intermediate Similarity	NPD3225	Approved
0.7006	Intermediate Similarity	NPD4625	Phase 3
0.7005	Intermediate Similarity	NPD4361	Phase 2
0.7005	Intermediate Similarity	NPD4362	Clinical (unspecified phase)
0.7	Intermediate Similarity	NPD9545	Approved
0.6977	Remote Similarity	NPD4288	Approved
0.6974	Remote Similarity	NPD7874	Approved

Bioactivity similarity: Similar Natural Products in NPASS

Bioactivity similarity was calculated based on bioactivity descriptors of compounds. The bioactivity descriptors were calculated by a recently developed AI algorithm Chemical Checker (CC) [Nature Biotechnology, 38:1087–1096, 2020; Nature Communications, 12:3932, 2021], which evaluated bioactivity similarities at five levels:
☉ A: chemistry similarity;
☉ B: biological targets similarity;
☉ C: networks similarity;
☉ D: cell-based bioactivity similarity;
☉ E: similarity based on clinical data.

Those 5 categories of CC bioactivity descriptors were calculated and then subjected to manifold projection using UMAP algorithm, to project all NPs on a 2-Dimensional space. The current NP was highlighted with a small circle in the 2-D map. Below figures: left-to-right, A-to-E.

A: chemistry similarity

B: biological targets similarity

C: networks similarity

D: cell-based bioactivity similarity

E: similarity based on clinical data