Structure

Physi-Chem Properties

Molecular Weight:  288.06
Volume:  276.613
LogP:  0.853
LogD:  0.259
LogS:  -2.725
# Rotatable Bonds:  1
TPSA:  107.22
# H-Bond Aceptor:  6
# H-Bond Donor:  4
# Rings:  3
# Heavy Atoms:  6

MedChem Properties

QED Drug-Likeness Score:  0.634
Synthetic Accessibility Score:  3.404
Fsp3:  0.133
Lipinski Rule-of-5:  Accepted
Pfizer Rule:  Accepted
GSK Rule:  Accepted
BMS Rule:  0
Golden Triangle Rule:  Accepted
Chelating Alert:  0
PAINS Alert:  0

ADMET Properties (ADMETlab2.0)

ADMET: Absorption

Caco-2 Permeability:  -5.609
MDCK Permeability:  4.219595666654641e-06
Pgp-inhibitor:  0.005
Pgp-substrate:  0.021
Human Intestinal Absorption (HIA):  0.012
20% Bioavailability (F20%):  0.715
30% Bioavailability (F30%):  0.099

ADMET: Distribution

Blood-Brain-Barrier Penetration (BBB):  0.029
Plasma Protein Binding (PPB):  82.65988159179688%
Volume Distribution (VD):  1.642
Pgp-substrate:  22.54766082763672%

ADMET: Metabolism

CYP1A2-inhibitor:  0.056
CYP1A2-substrate:  0.096
CYP2C19-inhibitor:  0.065
CYP2C19-substrate:  0.075
CYP2C9-inhibitor:  0.376
CYP2C9-substrate:  0.963
CYP2D6-inhibitor:  0.196
CYP2D6-substrate:  0.469
CYP3A4-inhibitor:  0.141
CYP3A4-substrate:  0.305

ADMET: Excretion

Clearance (CL):  6.523
Half-life (T1/2):  0.767

ADMET: Toxicity

hERG Blockers:  0.068
Human Hepatotoxicity (H-HT):  0.253
Drug-inuced Liver Injury (DILI):  0.94
AMES Toxicity:  0.154
Rat Oral Acute Toxicity:  0.341
Maximum Recommended Daily Dose:  0.201
Skin Sensitization:  0.896
Carcinogencity:  0.039
Eye Corrosion:  0.003
Eye Irritation:  0.876
Respiratory Toxicity:  0.367

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Structure MOL file  
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Biological Activities  
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  Natural Product: NPC62290

Natural Product ID:  NPC62290
Common Name*:   Dihydrokaempferol
IUPAC Name:   (2R,3R)-3,5,7-trihydroxy-2-(4-hydroxyphenyl)-2,3-dihydrochromen-4-one
Synonyms:  
Standard InCHIKey:  PADQINQHPQKXNL-LSDHHAIUSA-N
Standard InCHI:  InChI=1S/C15H12O6/c16-8-3-1-7(2-4-8)15-14(20)13(19)12-10(18)5-9(17)6-11(12)21-15/h1-6,14-18,20H/t14-,15+/m0/s1
SMILES:  c1cc(ccc1[C@@H]1[C@H](C(=O)c2c(cc(cc2O1)O)O)O)O
Synthetic Gene Cluster:   n.a.
ChEMBL Identifier:   CHEMBL9323
PubChem CID:   122850
Chemical Classification**:  
  • CHEMONTID:0000000 [Organic compounds]
    • [CHEMONTID:0000261] Phenylpropanoids and polyketides
      • [CHEMONTID:0000334] Flavonoids
        • [CHEMONTID:0000337] Flavans
          • [CHEMONTID:0001632] Flavanones
            • [CHEMONTID:0001362] Flavanonols

*Note: the InCHIKey will be temporarily assigned as the "Common Name" if no IUPAC name or alternative short name is available.
**Note: the Chemical Classification was calculated by NPClassifier Version 1.5. Reference: PMID:34662515.

  Species Source

Organism ID Organism Name Taxonomy Level Family SuperKingdom Isolation Part Collection Location Collection Time Reference
NPO27288 Citrus maxima Species Rutaceae Eukaryota n.a. n.a. n.a. DOI[10.1016/S0031-9422(99)00119-3]
NPO24176 Streptomyces fradiae Species Streptomycetaceae Bacteria n.a. n.a. n.a. PMID[10757717]
NPO23281 Aplysinella rhax Species Aplysinellidae Eukaryota n.a. n.a. n.a. PMID[10757728]
NPO17675 Andira inermis Species Fabaceae Eukaryota n.a. leaf n.a. PMID[11025148]
NPO5743 Salvia miltiorrhiza Species Lamiaceae Eukaryota n.a. root n.a. PMID[11374966]
NPO23982 Ventilago leiocarpa Species Rhamnaceae Eukaryota n.a. n.a. n.a. PMID[11374975]
NPO5495 Broussonetia papyrifera Species Moraceae Eukaryota n.a. root n.a. PMID[11395279]
NPO24219 Erylus nobilis Species n.a. n.a. n.a. n.a. n.a. PMID[11421740]
NPO20526 Menispermum dauricum Species Menispermaceae Eukaryota n.a. n.a. n.a. PMID[11473438]
NPO5495 Broussonetia papyrifera Species Moraceae Eukaryota whole plants n.a. n.a. PMID[11678652]
NPO5495 Broussonetia papyrifera Species Moraceae Eukaryota whole plants Shawnee National Forest, Harrisburg, IL, US n.a. PMID[11678652]
NPO28450 Phyllanthus emblica Species Phyllanthaceae Eukaryota n.a. n.a. n.a. PMID[11754604]
NPO24219 Erylus nobilis Species n.a. n.a. n.a. n.a. n.a. PMID[11908993]
NPO21963 Hypericum japonicum Species Hypericaceae Eukaryota n.a. n.a. n.a. PMID[11914965]
NPO11059 Callicarpa japonica Species Lamiaceae Eukaryota n.a. leaf n.a. PMID[12165300]
NPO24364 Petrosia corticata Species Petrosiidae Eukaryota n.a. n.a. n.a. PMID[12350165]
NPO5495 Broussonetia papyrifera Species Moraceae Eukaryota n.a. n.a. n.a. PMID[12419367]
NPO21361 Anastatica hierochuntica Species Brassicaceae Eukaryota n.a. n.a. n.a. PMID[12643908]
NPO2280 Streptomyces griseochromogenes Species Streptomycetaceae Bacteria n.a. n.a. n.a. PMID[12964155]
NPO24364 Petrosia corticata Species Petrosiidae Eukaryota n.a. Okinawan, Japan n.a. PMID[14695804]
NPO25546 Eucalyptus occidentalis Species Myrtaceae Eukaryota n.a. n.a. n.a. PMID[15104478]
NPO28952 Sapium haematospermum Species Euphorbiaceae Eukaryota n.a. n.a. n.a. PMID[15104489]
NPO24364 Petrosia corticata Species Petrosiidae Eukaryota n.a. n.a. n.a. PMID[15332859]
NPO30804 Cudrania tricuspidata Species Moraceae Eukaryota n.a. root n.a. PMID[15787460]
NPO30804 Cudrania tricuspidata Species Moraceae Eukaryota n.a. n.a. n.a. PMID[15787460]
NPO5743 Salvia miltiorrhiza Species Lamiaceae Eukaryota n.a. n.a. n.a. PMID[16038550]
NPO30804 Cudrania tricuspidata Species Moraceae Eukaryota n.a. n.a. n.a. PMID[16203143]
NPO25611 Smilax china Species Smilacaceae Eukaryota stems n.a. n.a. PMID[16252910]
NPO11789 Swertia decussata Species Gentianaceae Eukaryota n.a. n.a. n.a. PMID[16286309]
NPO19240 Ligularia cymbulifera Species Asteraceae Eukaryota Roots n.a. n.a. PMID[16643057]
NPO30804 Cudrania tricuspidata Species Moraceae Eukaryota n.a. n.a. n.a. PMID[16919944]
NPO15538 Eucalyptus citriodora Species Myrtaceae Eukaryota Leaves the campus of Panjab University, Chandigarh, India PMID[16989303]
NPO15505 Albizia gummifera Species Fabaceae Eukaryota n.a. root n.a. PMID[17263578]
NPO15505 Albizia gummifera Species Fabaceae Eukaryota Roots n.a. n.a. PMID[17263578]
NPO24639 Streptomyces filamentosus Species Streptomycetaceae Bacteria n.a. n.a. n.a. PMID[17284073]
NPO24364 Petrosia corticata Species Petrosiidae Eukaryota n.a. n.a. n.a. PMID[17407351]
NPO5743 Salvia miltiorrhiza Species Lamiaceae Eukaryota n.a. n.a. n.a. PMID[17583950]
NPO30804 Cudrania tricuspidata Species Moraceae Eukaryota root bark n.a. n.a. PMID[17608532]
NPO23281 Aplysinella rhax Species Aplysinellidae Eukaryota n.a. n.a. n.a. PMID[17827010]
NPO30804 Cudrania tricuspidata Species Moraceae Eukaryota n.a. n.a. n.a. PMID[17950599]
NPO8080 Sarcophyton elegans Species Alcyoniidae Eukaryota n.a. n.a. n.a. PMID[18004813]
NPO23911 Alpinia officinarum Species Zingiberaceae Eukaryota n.a. root n.a. PMID[18484537]
NPO23911 Alpinia officinarum Species Zingiberaceae Eukaryota n.a. rhizome n.a. PMID[18484537]
NPO733 Pseudoceratina arabica Species Pseudoceratinidae Eukaryota n.a. Red Sea n.a. PMID[18598078]
NPO20637 Piper acutifolium Species Piperaceae Eukaryota n.a. leaf n.a. PMID[18712933]
NPO5743 Salvia miltiorrhiza Species Lamiaceae Eukaryota n.a. n.a. n.a. PMID[18855446]
NPO5495 Broussonetia papyrifera Species Moraceae Eukaryota leaves Kaohsiung, Taiwan 2006-SEP PMID[18986201]
NPO30804 Cudrania tricuspidata Species Moraceae Eukaryota fruits n.a. n.a. PMID[19113968]
NPO2280 Streptomyces griseochromogenes Species Streptomycetaceae Bacteria n.a. n.a. n.a. PMID[19191560]
NPO30804 Cudrania tricuspidata Species Moraceae Eukaryota Roots n.a. n.a. PMID[19191562]
NPO30804 Cudrania tricuspidata Species Moraceae Eukaryota n.a. root n.a. PMID[19280148]
NPO30804 Cudrania tricuspidata Species Moraceae Eukaryota n.a. n.a. n.a. PMID[19285413]
NPO5495 Broussonetia papyrifera Species Moraceae Eukaryota Fruits n.a. n.a. PMID[19296617]
NPO17675 Andira inermis Species Fabaceae Eukaryota n.a. n.a. n.a. PMID[19299148]
NPO28450 Phyllanthus emblica Species Phyllanthaceae Eukaryota Roots Simao city, Yunnan Province, China 2007-MAY PMID[19374435]
NPO23911 Alpinia officinarum Species Zingiberaceae Eukaryota rhizomes n.a. n.a. PMID[19615910]
NPO30804 Cudrania tricuspidata Species Moraceae Eukaryota n.a. n.a. n.a. PMID[19660948]
NPO21361 Anastatica hierochuntica Species Brassicaceae Eukaryota n.a. n.a. n.a. PMID[20189399]
NPO5743 Salvia miltiorrhiza Species Lamiaceae Eukaryota n.a. n.a. n.a. PMID[20455578]
NPO23924 Psilotum nudum Species Psilotaceae Eukaryota n.a. n.a. n.a. PMID[20488581]
NPO7794 Vatica albiramis Species Dipterocarpaceae Eukaryota n.a. n.a. n.a. PMID[20735051]
NPO25224 Maytenus retusa Species Celastraceae Eukaryota n.a. n.a. n.a. PMID[21090801]
NPO23499 Carpesium faberi Species Asteraceae Eukaryota whole plant Changshou County, Chongqing, China 2008-Aug PMID[21109433]
NPO19832 Gambierdiscus toxicus Species Goniodomataceae Eukaryota n.a. n.a. n.a. PMID[21250701]
NPO30804 Cudrania tricuspidata Species Moraceae Eukaryota n.a. root n.a. PMID[21319773]
NPO29118 Euonymus alatus Species Celastraceae Eukaryota leaves and twigs n.a. n.a. PMID[21435874]
NPO9888 Lobophytum laevigatum Species Alcyoniidae Eukaryota n.a. Vietnamese n.a. PMID[21458279]
NPO9888 Lobophytum laevigatum Species Alcyoniidae Eukaryota n.a. Vietnamese soft coral n.a. PMID[21507644]
NPO26559 Glycine soja Species Fabaceae Eukaryota n.a. n.a. n.a. PMID[21545185]
NPO12644 Lunularia cruciata Species Lunulariaceae Eukaryota n.a. n.a. n.a. PMID[21625478]
NPO3648 Pittocaulon velatum Species Asteraceae Eukaryota n.a. root n.a. PMID[21661732]
NPO3648 Pittocaulon velatum Species Asteraceae Eukaryota n.a. stem n.a. PMID[21661732]
NPO5743 Salvia miltiorrhiza Species Lamiaceae Eukaryota n.a. n.a. n.a. PMID[21775156]
NPO5743 Salvia miltiorrhiza Species Lamiaceae Eukaryota n.a. n.a. n.a. PMID[23286284]
NPO2280 Streptomyces griseochromogenes Species Streptomycetaceae Bacteria n.a. n.a. n.a. PMID[23377931]
NPO546 Candida albicans Species Debaryomycetaceae Eukaryota n.a. n.a. n.a. PMID[23902158]
NPO4010 Flemingia philippinensis Species Fabaceae Eukaryota Roots n.a. n.a. PMID[24054487]
NPO5743 Salvia miltiorrhiza Species Lamiaceae Eukaryota n.a. n.a. n.a. PMID[24108414]
NPO4010 Flemingia philippinensis Species Fabaceae Eukaryota roots n.a. n.a. PMID[24412339]
NPO17475 Thermococcus kodakarensis Species Thermococcaceae Archaea n.a. n.a. n.a. PMID[24610711]
NPO15538 Eucalyptus citriodora Species Myrtaceae Eukaryota Essential oil n.a. n.a. PMID[24641242]
NPO30804 Cudrania tricuspidata Species Moraceae Eukaryota Roots n.a. n.a. PMID[25322455]
NPO20608 Gleditsia sinensis Species Fabaceae Eukaryota anomalous fruits n.a. n.a. PMID[25442304]
NPO3292 Desmodium styracifolium Species Fabaceae Eukaryota n.a. n.a. n.a. PMID[25620156]
NPO24364 Petrosia corticata Species Petrosiidae Eukaryota n.a. n.a. n.a. PMID[25987373]
NPO30804 Cudrania tricuspidata Species Moraceae Eukaryota root barks purchased from the local herbal market, Chungbuk, Korea 2012-JUL PMID[26227773]
NPO21963 Hypericum japonicum Species Hypericaceae Eukaryota n.a. n.a. n.a. PMID[27116034]
NPO5743 Salvia miltiorrhiza Species Lamiaceae Eukaryota n.a. n.a. n.a. PMID[27569393]
NPO4734 Syzygium nervosum Species Myrtaceae Eukaryota n.a. n.a. n.a. PMID[27797185]
NPO5743 Salvia miltiorrhiza Species Lamiaceae Eukaryota n.a. n.a. n.a. PMID[29185738]
NPO2722 Humulus japonicus Species Cannabaceae Eukaryota Aerial Parts n.a. n.a. PMID[29254897]
NPO23911 Alpinia officinarum Species Zingiberaceae Eukaryota n.a. n.a. n.a. PMID[29323912]
NPO21963 Hypericum japonicum Species Hypericaceae Eukaryota n.a. n.a. n.a. PMID[29667821]
NPO5743 Salvia miltiorrhiza Species Lamiaceae Eukaryota n.a. n.a. n.a. PMID[30351923]
NPO12644 Lunularia cruciata Species Lunulariaceae Eukaryota n.a. n.a. n.a. PMID[30848895]
NPO40254 Opuntia humifusa Species Cactaceae Eukaryota Cladodes n.a. n.a. PMID[32118424]
NPO5743 Salvia miltiorrhiza Species Lamiaceae Eukaryota n.a. root n.a. PMID[3655791]
NPO23911 Alpinia officinarum Species Zingiberaceae Eukaryota n.a. rhizome n.a. PMID[731398]
NPO23911 Alpinia officinarum Species Zingiberaceae Eukaryota n.a. root n.a. PMID[731398]
NPO7631 Gleditsia japonica Species Fabaceae Eukaryota Fruits n.a. n.a. PMID[7494144]
NPO24364 Petrosia corticata Species Petrosiidae Eukaryota n.a. n.a. n.a. PMID[7807132]
NPO20526 Menispermum dauricum Species Menispermaceae Eukaryota n.a. rhizome n.a. PMID[8281582]
NPO5495 Broussonetia papyrifera Species Moraceae Eukaryota n.a. formosan n.a. PMID[8864236]
NPO15505 Albizia gummifera Species Fabaceae Eukaryota n.a. n.a. n.a. PMID[8864238]
NPO11059 Callicarpa japonica Species Lamiaceae Eukaryota n.a. n.a. n.a. PMID[9222055]
NPO5495 Broussonetia papyrifera Species Moraceae Eukaryota n.a. n.a. n.a. PMID[9358644]
NPO5743 Salvia miltiorrhiza Species Lamiaceae Eukaryota roots n.a. n.a. PMID[9834151]
NPO27951 Vigna mungo Species Fabaceae Eukaryota Leaf Diffusate n.a. n.a. Database[FooDB]
NPO27951 Vigna mungo Species Fabaceae Eukaryota Seed n.a. n.a. Database[FooDB]
NPO27951 Vigna mungo Species Fabaceae Eukaryota Sprout Seedling n.a. n.a. Database[FooDB]
NPO27288 Citrus maxima Species Rutaceae Eukaryota n.a. n.a. Database[FooDB]
NPO27951 Vigna mungo Species Fabaceae Eukaryota n.a. n.a. Database[FooDB]
NPO18599 Pangium edule Species Achariaceae Eukaryota n.a. n.a. Database[FooDB]
NPO21963 Hypericum japonicum Species Hypericaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO31111 Ampelopsis brevipedunculata Species Vitaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO24178 Citrus rugulosa Species Rutaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO23911 Alpinia officinarum Species Zingiberaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO29118 Euonymus alatus Species Celastraceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO20608 Gleditsia sinensis Species Fabaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO30804 Cudrania tricuspidata Species Moraceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO26606 Macadamia ternifolia Species Proteaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO2340 Caulis spatholobi n.a. n.a. n.a. n.a. n.a. n.a. Database[HerDing]
NPO5279 Canarium commune Species Strombidae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO5743 Salvia miltiorrhiza Species Lamiaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO3292 Desmodium styracifolium Species Fabaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO17675 Andira inermis Species Fabaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO22455 Corydalis sewerzowi Species Papaveraceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO15786 Umbilicaria esculenta Species Umbilicariaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO5495 Broussonetia papyrifera Species Moraceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO25611 Smilax china Species Smilacaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO7132 Smilax glabra Species Smilacaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO14715 Trollius chinensis Species Ranunculaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO4967 Pedicularis decora Species Orobanchaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO28450 Phyllanthus emblica Species Phyllanthaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO4010 Flemingia philippinensis Species Fabaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO7001 Berberis floribunda Species Berberidaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO23982 Ventilago leiocarpa Species Rhamnaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO20526 Menispermum dauricum Species Menispermaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO23924 Psilotum nudum Species Psilotaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO2722 Humulus japonicus Species Cannabaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO21625 Bidens tripartita Species Asteraceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO27288 Citrus maxima Species Rutaceae Eukaryota n.a. n.a. Database[Phenol-Explorer]
NPO2340 Caulis spatholobi n.a. n.a. n.a. n.a. n.a. n.a. Database[TCMID]
NPO7319 Jamesoniella colorata Species Jungermanniaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO20608 Gleditsia sinensis Species Fabaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO23911 Alpinia officinarum Species Zingiberaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO29118 Euonymus alatus Species Celastraceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO7001 Berberis floribunda Species Berberidaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO17749 Jackiella javanica Species Jackiellaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO29193 Nekemias grossedentata Species Vitaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO15538 Eucalyptus citriodora Species Myrtaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO21625 Bidens tripartita Species Asteraceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO21963 Hypericum japonicum Species Hypericaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO22636 Sterculia foetida Species Malvaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO25611 Smilax china Species Smilacaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO5279 Canarium commune Species Strombidae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO5271.1 Ampelopsis glandulosa var. brevipedunculata Varieties Vitaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO24178 Citrus rugulosa Species Rutaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO26606 Macadamia ternifolia Species Proteaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO14715 Trollius chinensis Species Ranunculaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO23924 Psilotum nudum Species Psilotaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO28450 Phyllanthus emblica Species Phyllanthaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO3292 Desmodium styracifolium Species Fabaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO17675 Andira inermis Species Fabaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO16978 Entada phaseoloides Species Fabaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO22455 Corydalis sewerzowi Species Papaveraceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO4967 Pedicularis decora Species Orobanchaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO7132 Smilax glabra Species Smilacaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO277 Caulis millettiae n.a. n.a. n.a. n.a. n.a. n.a. Database[TCMID]
NPO20526 Menispermum dauricum Species Menispermaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO9452 Pulsatilla campanella Species Ranunculaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO21458 Radix paeoniae rubra Species Lymnaeidae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO27288 Citrus maxima Species Rutaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO5495 Broussonetia papyrifera Species Moraceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO5743 Salvia miltiorrhiza Species Lamiaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO2722 Humulus japonicus Species Cannabaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO8701 Bonamia spectabilis Species Convolvulaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO23982 Ventilago leiocarpa Species Rhamnaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO1334 Senegalia catechu Species Fabaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO15786 Umbilicaria esculenta Species Umbilicariaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO11059 Callicarpa japonica Species Lamiaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO4010 Flemingia philippinensis Species Fabaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO22636 Sterculia foetida Species Malvaceae Eukaryota n.a. n.a. n.a. Database[TCM_Taiwan]
NPO7132 Smilax glabra Species Smilacaceae Eukaryota n.a. n.a. n.a. Database[TCM_Taiwan]
NPO25611 Smilax china Species Smilacaceae Eukaryota n.a. n.a. n.a. Database[TCM_Taiwan]
NPO21963 Hypericum japonicum Species Hypericaceae Eukaryota n.a. n.a. n.a. Database[TCM_Taiwan]
NPO31111 Ampelopsis brevipedunculata Species Vitaceae Eukaryota n.a. n.a. n.a. Database[TCM_Taiwan]
NPO20608 Gleditsia sinensis Species Fabaceae Eukaryota n.a. n.a. n.a. Database[TCM_Taiwan]
NPO28450 Phyllanthus emblica Species Phyllanthaceae Eukaryota n.a. n.a. n.a. Database[TCM_Taiwan]
NPO5495 Broussonetia papyrifera Species Moraceae Eukaryota n.a. n.a. n.a. Database[TCM_Taiwan]
NPO16978 Entada phaseoloides Species Fabaceae Eukaryota n.a. n.a. n.a. Database[TCM_Taiwan]
NPO30804 Cudrania tricuspidata Species Moraceae Eukaryota n.a. n.a. n.a. Database[TCM_Taiwan]
NPO5743 Salvia miltiorrhiza Species Lamiaceae Eukaryota n.a. n.a. n.a. Database[TCM_Taiwan]
NPO4010 Flemingia philippinensis Species Fabaceae Eukaryota n.a. n.a. n.a. Database[TCM_Taiwan]
NPO23911 Alpinia officinarum Species Zingiberaceae Eukaryota n.a. n.a. n.a. Database[TCM_Taiwan]
NPO3292 Desmodium styracifolium Species Fabaceae Eukaryota n.a. n.a. n.a. Database[TCM_Taiwan]
NPO29118 Euonymus alatus Species Celastraceae Eukaryota n.a. n.a. n.a. Database[TCM_Taiwan]
NPO2722 Humulus japonicus Species Cannabaceae Eukaryota n.a. n.a. n.a. Database[TCM_Taiwan]
NPO20526 Menispermum dauricum Species Menispermaceae Eukaryota n.a. n.a. n.a. Database[TCM_Taiwan]
NPO24090 Aplysilla rosea Species Darwinellidae Eukaryota n.a. Austrila n.a. Database[Title]
NPO29118 Euonymus alatus Species Celastraceae Eukaryota n.a. n.a. n.a. Database[TM-MC]
NPO7631 Gleditsia japonica Species Fabaceae Eukaryota n.a. n.a. n.a. Database[TM-MC]
NPO28450 Phyllanthus emblica Species Phyllanthaceae Eukaryota n.a. n.a. n.a. Database[TM-MC]
NPO16978 Entada phaseoloides Species Fabaceae Eukaryota n.a. n.a. n.a. Database[TM-MC]
NPO1334 Senegalia catechu Species Fabaceae Eukaryota n.a. n.a. n.a. Database[TM-MC]
NPO5743 Salvia miltiorrhiza Species Lamiaceae Eukaryota n.a. n.a. n.a. Database[TM-MC]
NPO23911 Alpinia officinarum Species Zingiberaceae Eukaryota n.a. n.a. n.a. Database[TM-MC]
NPO20608 Gleditsia sinensis Species Fabaceae Eukaryota n.a. n.a. n.a. Database[TM-MC]
NPO3292 Desmodium styracifolium Species Fabaceae Eukaryota n.a. n.a. n.a. Database[TM-MC]
NPO27288 Citrus maxima Species Rutaceae Eukaryota n.a. n.a. n.a. Database[TM-MC]
NPO25611 Smilax china Species Smilacaceae Eukaryota n.a. n.a. n.a. Database[TM-MC]
NPO5495 Broussonetia papyrifera Species Moraceae Eukaryota n.a. n.a. n.a. Database[TM-MC]
NPO7132 Smilax glabra Species Smilacaceae Eukaryota n.a. n.a. n.a. Database[TM-MC]
NPO11106 0thofagus dombeyi Species 0thofagaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO24176 Streptomyces fradiae Species Streptomycetaceae Bacteria n.a. n.a. n.a. Database[UNPD]
NPO27288 Citrus maxima Species Rutaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO23211 Xyris indica Species Xyridaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO22636 Sterculia foetida Species Malvaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO19706 Polyzonium rosalbum Species Polyzoniidae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO20998 Machaerium kuhlmannii Species Dolichopodidae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO24901 Ochna obtusata Species Ochnaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO3658 Achillea pseudopectinata Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO2354 Rhizobium leguminosarum Species Rhizobiaceae Bacteria n.a. n.a. n.a. Database[UNPD]
NPO19086 Nematolepis phebalioides Species Rutaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO12109 Cyathocline lyrata Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO9452 Pulsatilla campanella Species Ranunculaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO11127 Inulanthera calva Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO23318 Aconitum palmatum Species Ranunculaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO23499 Carpesium faberi Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO24408 Ariocarpus fissuratus Species Cactaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO21963 Hypericum japonicum Species Hypericaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO6822 Aristotelia australasica Species Elaeocarpaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO9009 Atuna racemosa Species Chrysobalanaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO19370 Coprosma areolata Species Rubiaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO15786 Umbilicaria esculenta Species Umbilicariaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO24432 Oxylobus oaxacanus n.a. n.a. n.a. n.a. n.a. n.a. Database[UNPD]
NPO12152 Nicotiana raimondii Species Solanaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO29193 Nekemias grossedentata Species Vitaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO2280 Streptomyces griseochromogenes Species Streptomycetaceae Bacteria n.a. n.a. n.a. Database[UNPD]
NPO23834 Chlamydomonas allensworthii Species Chlamydomonadaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO14214 Sedum obtuso-lineare Species Crassulaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO15385 Achillea lycaonica Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO29118 Euonymus alatus Species Celastraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO15135 Pleuronectes cynoglossus Species Pleuronectidae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO24178 Citrus rugulosa Species Rutaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO23712 Gardenia lucida Species Rubiaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO15643 Asterias nipon Species Asteriidae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO11612 Protea roupelliae Species Proteaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO23961 Scytonema ocellatum Species Scytonemataceae Bacteria n.a. n.a. n.a. Database[UNPD]
NPO26722 Dorstenia dinklagei Species Moraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO15505 Albizia gummifera Species Fabaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO17749 Jackiella javanica Species Jackiellaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO4010 Flemingia philippinensis Species Fabaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO19766 Viguiera linearis Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO18672 Senecio adenophyllus Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO18163 Aulosira fertilissima Species Fortieaceae Bacteria n.a. n.a. n.a. Database[UNPD]
NPO3311 Diplacus longiflorus Species Phrymaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO21625 Bidens tripartita Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO9274 Acripeza reticulata n.a. n.a. n.a. n.a. n.a. n.a. Database[UNPD]
NPO24132 Euphausia superba Species Euphausiidae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO18422 Stizolobium deeringianum n.a. n.a. n.a. n.a. n.a. n.a. Database[UNPD]
NPO19535 Senecio zoellneri Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO1646 Balsamorhiza hookeri Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO24364 Petrosia corticata Species Petrosiidae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO24090 Aplysilla rosea Species Darwinellidae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO22595 Trapa bicornis Species Lythraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO16421 Chalciporus piperatus Species Boletaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO901 Flourensia ilicifolia Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO11223 Pleurotus japonicus Species Pleurotaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO26768 Lichtheimia blakesleeana Species Lichtheimiaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO18345 Phora velutina Species Phoridae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO17894 Rhus vulgaris Species Anacardiaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO24019 Sapindus emarginatus Species Sapindaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO25611 Smilax china Species Smilacaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO19168 Solidago flexicaulis Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO13127 Vallaris heynei Species Apocynaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO18925 Artemisia rehan Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO12860 Clione antarctica Species Clionidae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO13727 Hemionitis japonica Species Pteridaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO546 Candida albicans Species Debaryomycetaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO23696 Solanum diflorum Species Solanaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO12864 Trogoderma granarium Species Dermestidae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO7627 Fumaria micrantha Species Papaveraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO21565 Ceramaster patagonicus Species Goniasteridae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO15119 Aphis graminum Species Aphididae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO21827 Albatrellus caeruleoporus Species Albatrellaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO11789 Swertia decussata Species Gentianaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO2565 Aglaia australiensis Species Meliaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO25224 Maytenus retusa Species Celastraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO7132 Smilax glabra Species Smilacaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO17350 Jatropha macrorhiza Species Euphorbiaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO5782 Aniba rosaeodora Species Lauraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO11083 Avrainvillea longicaulis Species Udoteaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO8080 Sarcophyton elegans Species Alcyoniidae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO23911 Alpinia officinarum Species Zingiberaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO22143 Genista sessilifolia Species Fabaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO5271.1 Ampelopsis glandulosa var. brevipedunculata Varieties Vitaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO24005 Mytilus galloprovincialis Species Mytilidae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO11323 Siphonochilus aethiopicus Species Zingiberaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO23899 Rosulabryum capillare Species Bryaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO8593 Zygosaccharomyces rouxii Species Saccharomycetaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO17675 Andira inermis Species Fabaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO12284 Hydrangea serrata Species Hydrangeaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO26531 Aeschrion excelsa n.a. n.a. n.a. n.a. n.a. n.a. Database[UNPD]
NPO9830 Arum maximum Species Araceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO7949 Pterodon emarginatus Species Fabaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO15538 Eucalyptus citriodora Species Myrtaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO23920 Amanita pseudoporphyria Species Amanitaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO18839 Lilium umbellatum Species Liliaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO7011 Chamomilla recutita n.a. n.a. n.a. n.a. n.a. n.a. Database[UNPD]
NPO7319 Jamesoniella colorata Species Jungermanniaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO23043 Cryptolestes pusillus Species Laemophloeidae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO18260 Eremanthus seidelii Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO23982 Ventilago leiocarpa Species Rhamnaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO15437 Aspergillus desertorum Species Aspergillaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO25546 Eucalyptus occidentalis Species Myrtaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO2561 Capnella erecta Species Nephtheidae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO18976 Centaurea arbutifolia Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO9888 Lobophytum laevigatum Species Alcyoniidae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO26403 Brachymeris montana n.a. n.a. n.a. n.a. n.a. n.a. Database[UNPD]
NPO7794 Vatica albiramis Species Dipterocarpaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO23413 Crematogaster africana Species Formicidae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO19832 Gambierdiscus toxicus Species Goniodomataceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO12169 Ranunculus peltatus Species Ranunculaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO18599 Pangium edule Species Achariaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO11059 Callicarpa japonica Species Lamiaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO19571 Oreopteris quelpaertensis Species Thelypteridaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO5495 Broussonetia papyrifera Species Moraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO21361 Anastatica hierochuntica Species Brassicaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO733 Pseudoceratina arabica Species Pseudoceratinidae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO9226 Astragalus pycnanthus Species Fabaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO16978 Entada phaseoloides Species Fabaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO24048 Cladonia pityrea Species Cladoniaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO20637 Piper acutifolium Species Piperaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO17056 Ligularia anoleuca Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO11910 Peltogyne pubescens Species Fabaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO20608 Gleditsia sinensis Species Fabaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO6572 Dunalia solanacea Species Solanaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO11534 Astragalus spinosus Species Fabaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO16776 Euphorbia amygdaloides Species Euphorbiaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO7001 Berberis floribunda Species Berberidaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO17737 Lepidorhinus squamosus n.a. n.a. n.a. n.a. n.a. n.a. Database[UNPD]
NPO14249 Diplodia natalensis Species Botryosphaeriaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO24856 Calea subcordata Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO24639 Streptomyces filamentosus Species Streptomycetaceae Bacteria n.a. n.a. n.a. Database[UNPD]
NPO23364 Lambertella corni Species Rutstroemiaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO12644 Lunularia cruciata Species Lunulariaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO3648 Pittocaulon velatum Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO24290 Claviceps microcephala Species Clavicipitaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO8701 Bonamia spectabilis Species Convolvulaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO8308 Bryocaulon pseudosatoanum Species Parmeliaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO8842 Neurymenia fraxinifolia Species Rhodomelaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO10546 Allagopappus viscosissimus Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO3292 Desmodium styracifolium Species Fabaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO25342 Veronica virginica Species Plantaginaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO24249 Codonopsis cordifolioidea Species Campanulaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO23924 Psilotum nudum Species Psilotaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO25204 Millettia thonningii Species Fabaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO4061 Trollius europaeus Species Ranunculaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO28952 Sapium haematospermum Species Euphorbiaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO13344 Helichrysum cephaloideum Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO12429 Acicarpha tribuloides Species Calyceraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO21187 Leucanthemopsis pallida Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO23739 Staehelina fruticosa Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO8398 Cymodocea nodosa Species Cymodoceaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO15481 Hypericum balearicum Species Hypericaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO5279 Canarium commune Species Strombidae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO26881 Croton zehntneri Species Euphorbiaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO17222 Hesperis matronalis Species Brassicaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO22860 Veronica orientalis Species Plantaginaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO20526 Menispermum dauricum Species Menispermaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO18447 Papaver tatricum Species Papaveraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO1334 Senegalia catechu Species Fabaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO10917 Junceella gemmacea Species Ellisellidae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO23114 Cacalia robusta Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO6422 Aldina heterophylla Species Fabaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO23792 Gomphostemma parviflorum Species Lamiaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO4499 Aglaia formosana Species Meliaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO23281 Aplysinella rhax Species Aplysinellidae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO7631 Gleditsia japonica Species Fabaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO21660 Magnolia montana Species Magnoliaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO24445 Arbacia pustulosa Species Arbaciidae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO22324 Erium villosum Species Pseudococcidae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO4967 Pedicularis decora Species Orobanchaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO26532 Gmelina asiatica Species Lamiaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO17475 Thermococcus kodakarensis Species Thermococcaceae Archaea n.a. n.a. n.a. Database[UNPD]
NPO16316 Cylindrospermum muscicola Species 0stocaceae Bacteria n.a. n.a. n.a. Database[UNPD]
NPO23459 Onoseris alata Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO15439 Iyengaria stellata Species Scytosiphonaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO4910 Lepidosperma ustulatum Species Cyperaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO5743 Salvia miltiorrhiza Species Lamiaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO23884 Hippobroma longiflora Species Campanulaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO26606 Macadamia ternifolia Species Proteaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO23610 Aconitum tianschanicum Species Ranunculaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO2722 Humulus japonicus Species Cannabaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO23545 Vellozia streptophylla Species Velloziaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO8006 Berlinia tomentosa Species Fabaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO26656 Heliotropium hirsutissimum Species Heliotropiaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO16132 Bryum argenteum Species Bryaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO19240 Ligularia cymbulifera Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO22455 Corydalis sewerzowi Species Papaveraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO25103 Stauranthus perforatus n.a. n.a. n.a. n.a. n.a. n.a. Database[UNPD]
NPO12229 Woodwardia prolifera Species Blechnaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO10311 Lippia citriodora Species Verbenaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO27951 Vigna mungo Species Fabaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO26559 Glycine soja Species Fabaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO18041 Cladrastis platycarpa Species Fabaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO24219 Erylus nobilis Species n.a. n.a. n.a. n.a. n.a. Database[UNPD]
NPO15875 Scolopia chinensis Species Salicaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO9640 Dinophysis fortii Species Dinophysiaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO19631 Aphis pini Species Aphididae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO17490 Trichophyton mentagrophytes Species Arthrodermataceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO14715 Trollius chinensis Species Ranunculaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO28450 Phyllanthus emblica Species Phyllanthaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO738 Dahlstedtia pentaphylla Species Fabaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO19010 Elephantopus hirtiflorus Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO4734 Syzygium nervosum Species Myrtaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO16043 Centaurea musimomum Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO19306 Cortinarius orellanus Species Cortinariaceae Eukaryota n.a. n.a. n.a. Database[UNPD]

☑ Note for Reference:
In addition to directly collecting NP source organism data from primary literature (where reference will provided as NCBI PMID or DOI links), NPASS also integrated them from below databases:
☉ UNPD: Universal Natural Products Database [PMID: 23638153].
☉ StreptomeDB: a database of streptomycetes natural products [PMID: 33051671].
☉ TM-MC: a database of medicinal materials and chemical compounds in Northeast Asian traditional medicine [PMID: 26156871].
☉ TCM@Taiwan: a Traditional Chinese Medicine database [PMID: 21253603].
☉ TCMID: a Traditional Chinese Medicine database [PMID: 29106634].
☉ TCMSP: The traditional Chinese medicine systems pharmacology database and analysis platform [PMID: 24735618].
☉ HerDing: a herb recommendation system to treat diseases using genes and chemicals [PMID: 26980517].
☉ MetaboLights: a metabolomics database [PMID: 27010336].
☉ FooDB: a database of constituents, chemistry and biology of food species [www.foodb.ca].

  NP Quantity Composition/Concentration

Organism ID NP ID Organism Material Preparation Organism Part NP Quantity (Standard) NP Quantity (Minimum) NP Quantity (Maximum) Quantity Unit Reference

☑ Note for Reference:
In addition to directly collecting NP quantitative data from primary literature (where reference will provided as NCBI PMID or DOI links), NPASS also integrated NP quantitative records for specific NP domains (e.g., NPS from foods or herbs) from domain-specific databases. These databases include:
☉ DUKE: Dr. Duke's Phytochemical and Ethnobotanical Databases.
☉ PHENOL EXPLORER: is the first comprehensive database on polyphenol content in foods [PMID: 24103452], its homepage can be accessed at here.
☉ FooDB: a database of constituents, chemistry and biology of food species [www.foodb.ca].

  Biological Activity

Target ID Target Type Target Name Target Organism Activity Type Activity Relation Value Unit Reference
NPT1310 Individual Protein Xanthine dehydrogenase Bos taurus Inhibition = 66.9 % PMID[517876]
NPT1310 Individual Protein Xanthine dehydrogenase Bos taurus IC50 = 93800.0 nM PMID[517876]
NPT1306 Cell Line WISH Homo sapiens IC50 > 100000.0 nM PMID[517877]
NPT189 Cell Line Vero Chlorocebus aethiops IC50 > 100000.0 nM PMID[517877]
NPT80 Cell Line Raji Homo sapiens IC50 > 100000.0 nM PMID[517877]
NPT111 Cell Line K562 Homo sapiens IC50 > 100000.0 nM PMID[517877]
NPT165 Cell Line HeLa Homo sapiens IC50 > 100000.0 nM PMID[517877]
NPT1307 Cell Line Calu-1 Homo sapiens IC50 > 100000.0 nM PMID[517877]
NPT441 Individual Protein Cytochrome P450 19A1 Homo sapiens IC50 > 40.0 ug.mL-1 PMID[517878]
NPT319 Cell Line B16 Mus musculus IC50 = 84000.0 nM PMID[517880]
NPT43 Individual Protein Tyrosinase Agaricus bisporus Inhibition = 6.0 % PMID[517880]
NPT43 Individual Protein Tyrosinase Agaricus bisporus Inhibition = 4.4 % PMID[517880]
NPT43 Individual Protein Tyrosinase Agaricus bisporus Inhibition = 6.3 % PMID[517880]
NPT43 Individual Protein Tyrosinase Agaricus bisporus Inhibition = 7.9 % PMID[517880]
NPT43 Individual Protein Tyrosinase Agaricus bisporus Inhibition = 21.0 % PMID[517880]
NPT43 Individual Protein Tyrosinase Agaricus bisporus IC50 > 100000.0 nM PMID[517880]
NPT135 Individual Protein Chromobox protein homolog 1 Homo sapiens Potency n.a. 2511.9 nM PMID[517885]
NPT10 Individual Protein Geminin Homo sapiens Potency n.a. 819.9 nM PMID[517885]
NPT114 Cell Line LoVo Homo sapiens Activity = 10.02 % PMID[517886]
NPT114 Cell Line LoVo Homo sapiens Activity = 10.96 % PMID[517886]
NPT1650 Individual Protein Tyrosine-protein kinase receptor FLT3 Homo sapiens IC50 > 10000.0 nM PMID[517887]
NPT1120 Individual Protein Pancreatic triacylglycerol lipase Sus scrofa IC50 > 100000.0 nM PMID[517888]
NPT1120 Individual Protein Pancreatic triacylglycerol lipase Sus scrofa Inhibition = 10.8 % PMID[517888]
NPT113 Cell Line RAW264.7 Mus musculus Inhibition < 10.0 % PMID[517890]
NPT113 Cell Line RAW264.7 Mus musculus IC50 > 100000.0 nM PMID[517892]
NPT43 Individual Protein Tyrosinase Agaricus bisporus KA = 0.094 10'6L/mol PMID[517894]
NPT43 Individual Protein Tyrosinase Agaricus bisporus KSV = 0.0199 10'4L/mol PMID[517894]
NPT43 Individual Protein Tyrosinase Agaricus bisporus IC50 > 200000.0 nM PMID[517894]
NPT43 Individual Protein Tyrosinase Agaricus bisporus Ki = 42000.0 nM PMID[517894]
NPT43 Individual Protein Tyrosinase Agaricus bisporus IC50 = 73600.0 nM PMID[517894]
NPT32 Organism Mus musculus Mus musculus Inhibition = 0.0 % PMID[517875]
NPT32 Organism Mus musculus Mus musculus Inhibition = 7.8 % PMID[517875]
NPT32 Organism Mus musculus Mus musculus Inhibition = 14.2 % PMID[517875]
NPT32 Organism Mus musculus Mus musculus Inhibition = 33.2 % PMID[517875]
NPT2566 Organism Coniophora puteana Coniophora puteana IZ = 10.0 mm PMID[517879]
NPT2 Others Unspecified Inhibition = 8.7 % PMID[517880]
NPT2 Others Unspecified Inhibition = 1.2 % PMID[517880]
NPT2 Others Unspecified Inhibition = 12.7 % PMID[517880]
NPT2 Others Unspecified Inhibition = 20.5 % PMID[517880]
NPT2 Others Unspecified Inhibition = 56.0 % PMID[517880]
NPT20529 NON-MOLECULAR NON-PROTEIN TARGET n.a. Inhibition = 0.2 % PMID[517880]
NPT20529 NON-MOLECULAR NON-PROTEIN TARGET n.a. Inhibition = 5.9 % PMID[517880]
NPT20529 NON-MOLECULAR NON-PROTEIN TARGET n.a. Inhibition = 13.8 % PMID[517880]
NPT20529 NON-MOLECULAR NON-PROTEIN TARGET n.a. Inhibition = 23.9 % PMID[517880]
NPT20529 NON-MOLECULAR NON-PROTEIN TARGET n.a. Inhibition = 30.5 % PMID[517880]
NPT20529 NON-MOLECULAR NON-PROTEIN TARGET n.a. IC50 > 100000.0 nM PMID[517880]
NPT2 Others Unspecified IC50 = 153100.0 nM PMID[517881]
NPT2 Others Unspecified Inhibition = 6.0 % PMID[517882]
NPT2 Others Unspecified Inhibition = 14.4 % PMID[517882]
NPT2 Others Unspecified Inhibition = -5.2 % PMID[517882]
NPT2 Others Unspecified Inhibition = 7.0 % PMID[517882]
NPT27 Others Unspecified Inhibition < 8.8 % PMID[517882]
NPT20529 NON-MOLECULAR NON-PROTEIN TARGET n.a. Activity = 1.39 MU PMID[517883]
NPT1 Others Radical scavenging activity EC50 > 100.0 ug PMID[517884]
NPT2 Others Unspecified Activity = 6.83 % PMID[517886]
NPT2 Others Unspecified Activity = 9.38 % PMID[517886]
NPT35 Others n.a. EC50 > 100000.0 nM PMID[517890]
NPT2 Others Unspecified IC50 = 154.7 ug.mL-1 PMID[517891]
NPT78 Individual Protein Beta amyloid A4 protein Homo sapiens IC50 > 500000.0 nM PMID[517893]

☑ Note for Activity Records:
☉ The quantitative biological activities were primarily integrated from ChEMBL (Version-30) database and were also directly collected from PubMed literature. PubMed PMID was provided as the reference link for each activity record.

  Chemically structural similarity: I. Similar Active Natural Products in NPASS

Top-200 similar NPs were calculated against the active-NP-set (includes 4,3285 NPs with experimentally-derived bioactivity available in NPASS)

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules. Tc lies between [0, 1] where '1' indicates the highest similarity. What is Tanimoto coefficient

●  The left chart: Distribution of similarity level between NPC62290 and all remaining natural products in the NPASS database.
●  The right table: Most similar natural products (Tc>=0.56 or Top200).

Similarity Score Similarity Level Natural Product ID
1.0 High Similarity NPC279417
1.0 High Similarity NPC142731
1.0 High Similarity NPC4152
1.0 High Similarity NPC306607
1.0 High Similarity NPC208176
1.0 High Similarity NPC326506
1.0 High Similarity NPC49130
0.9928 High Similarity NPC1940
0.9928 High Similarity NPC148011
0.9857 High Similarity NPC476182
0.9857 High Similarity NPC211466
0.9857 High Similarity NPC176869
0.9857 High Similarity NPC40086
0.9857 High Similarity NPC44721
0.9857 High Similarity NPC3779
0.9857 High Similarity NPC122828
0.9787 High Similarity NPC218569
0.9716 High Similarity NPC21835
0.9645 High Similarity NPC229190
0.964 High Similarity NPC150023
0.9583 High Similarity NPC262039
0.9583 High Similarity NPC278476
0.9583 High Similarity NPC262038
0.9583 High Similarity NPC254412
0.9583 High Similarity NPC319910
0.9577 High Similarity NPC472918
0.9517 High Similarity NPC243171
0.9517 High Similarity NPC138288
0.9517 High Similarity NPC61506
0.9517 High Similarity NPC260491
0.9517 High Similarity NPC240476
0.9517 High Similarity NPC171651
0.9517 High Similarity NPC35567
0.9517 High Similarity NPC216035
0.9517 High Similarity NPC9743
0.9517 High Similarity NPC36835
0.9517 High Similarity NPC217149
0.9517 High Similarity NPC246162
0.9514 High Similarity NPC105136
0.9493 High Similarity NPC12296
0.9493 High Similarity NPC243083
0.9493 High Similarity NPC32441
0.9493 High Similarity NPC287246
0.9493 High Similarity NPC13768
0.9493 High Similarity NPC295261
0.9493 High Similarity NPC296490
0.9493 High Similarity NPC107586
0.9493 High Similarity NPC79943
0.9452 High Similarity NPC325028
0.9452 High Similarity NPC27532
0.9452 High Similarity NPC244250
0.9452 High Similarity NPC246328
0.9452 High Similarity NPC256346
0.9452 High Similarity NPC20907
0.9452 High Similarity NPC293286
0.9452 High Similarity NPC268193
0.9444 High Similarity NPC277032
0.9444 High Similarity NPC477941
0.9424 High Similarity NPC147686
0.9424 High Similarity NPC329225
0.9424 High Similarity NPC472460
0.9388 High Similarity NPC111341
0.9388 High Similarity NPC48579
0.9388 High Similarity NPC207809
0.9388 High Similarity NPC304207
0.9388 High Similarity NPC304745
0.9388 High Similarity NPC259710
0.9388 High Similarity NPC217706
0.9384 High Similarity NPC19721
0.9379 High Similarity NPC267117
0.9357 High Similarity NPC310135
0.9357 High Similarity NPC274784
0.9357 High Similarity NPC329203
0.9357 High Similarity NPC20709
0.9357 High Similarity NPC265871
0.9357 High Similarity NPC222342
0.9357 High Similarity NPC150648
0.9357 High Similarity NPC225153
0.9353 High Similarity NPC476480
0.9353 High Similarity NPC84585
0.9353 High Similarity NPC287068
0.9324 High Similarity NPC320825
0.9324 High Similarity NPC10754
0.9324 High Similarity NPC201837
0.9324 High Similarity NPC20530
0.9324 High Similarity NPC215917
0.9324 High Similarity NPC326037
0.9324 High Similarity NPC13858
0.932 High Similarity NPC203080
0.932 High Similarity NPC180301
0.932 High Similarity NPC248793
0.9315 High Similarity NPC209846
0.9315 High Similarity NPC471677
0.9315 High Similarity NPC471229
0.9315 High Similarity NPC472422
0.9315 High Similarity NPC472420
0.9315 High Similarity NPC471676
0.9315 High Similarity NPC328740
0.9315 High Similarity NPC263384
0.9315 High Similarity NPC289774
0.9315 High Similarity NPC295650
0.9315 High Similarity NPC477897
0.9315 High Similarity NPC244577
0.931 High Similarity NPC472628
0.9306 High Similarity NPC472627
0.9291 High Similarity NPC6407
0.9291 High Similarity NPC110228
0.9291 High Similarity NPC188243
0.9291 High Similarity NPC182421
0.9286 High Similarity NPC118813
0.9281 High Similarity NPC187432
0.9281 High Similarity NPC256042
0.9281 High Similarity NPC281917
0.9281 High Similarity NPC116775
0.9281 High Similarity NPC216361
0.9262 High Similarity NPC52530
0.9262 High Similarity NPC6985
0.9252 High Similarity NPC475790
0.9252 High Similarity NPC259182
0.9252 High Similarity NPC121001
0.9252 High Similarity NPC210597
0.9252 High Similarity NPC150123
0.9252 High Similarity NPC244583
0.9252 High Similarity NPC10807
0.9252 High Similarity NPC161881
0.9252 High Similarity NPC56232
0.9241 High Similarity NPC294852
0.9241 High Similarity NPC321011
0.9241 High Similarity NPC188679
0.9236 High Similarity NPC472629
0.9225 High Similarity NPC312391
0.9225 High Similarity NPC324386
0.9225 High Similarity NPC4743
0.9225 High Similarity NPC213322
0.922 High Similarity NPC261234
0.922 High Similarity NPC241838
0.922 High Similarity NPC152042
0.922 High Similarity NPC143799
0.922 High Similarity NPC316480
0.922 High Similarity NPC140890
0.9214 High Similarity NPC290291
0.9214 High Similarity NPC299379
0.9214 High Similarity NPC275055
0.9209 High Similarity NPC9985
0.9209 High Similarity NPC239495
0.92 High Similarity NPC123544
0.92 High Similarity NPC22192
0.9195 High Similarity NPC323593
0.9195 High Similarity NPC307938
0.9195 High Similarity NPC471500
0.9195 High Similarity NPC250922
0.9195 High Similarity NPC203500
0.9189 High Similarity NPC236756
0.9189 High Similarity NPC106625
0.9189 High Similarity NPC141212
0.9189 High Similarity NPC209760
0.9189 High Similarity NPC100134
0.9189 High Similarity NPC311579
0.9189 High Similarity NPC109594
0.9189 High Similarity NPC472583
0.9189 High Similarity NPC7989
0.9189 High Similarity NPC326592
0.9189 High Similarity NPC112701
0.9189 High Similarity NPC223701
0.9184 High Similarity NPC472636
0.9184 High Similarity NPC474021
0.9184 High Similarity NPC474023
0.9178 High Similarity NPC1612
0.9178 High Similarity NPC183959
0.9178 High Similarity NPC89442
0.9172 High Similarity NPC85773
0.9167 High Similarity NPC87486
0.9167 High Similarity NPC470890
0.9167 High Similarity NPC124780
0.9161 High Similarity NPC220998
0.9161 High Similarity NPC73028
0.9161 High Similarity NPC32739
0.9161 High Similarity NPC265040
0.9161 High Similarity NPC10937
0.9161 High Similarity NPC296917
0.9161 High Similarity NPC228504
0.9161 High Similarity NPC227579
0.9161 High Similarity NPC76338
0.9161 High Similarity NPC324436
0.9161 High Similarity NPC223500
0.9161 High Similarity NPC64915
0.9161 High Similarity NPC66515
0.9161 High Similarity NPC324134
0.9161 High Similarity NPC76372
0.9161 High Similarity NPC161506
0.9161 High Similarity NPC37496
0.9161 High Similarity NPC107572
0.9161 High Similarity NPC78
0.9161 High Similarity NPC166482
0.9161 High Similarity NPC40833
0.9161 High Similarity NPC166934
0.9161 High Similarity NPC306829
0.9161 High Similarity NPC182852
0.9161 High Similarity NPC177354
0.9161 High Similarity NPC148757

  Chemically structural similarity: II. Similar Clinical/Approved Drugs

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules.

●  The left chart: Distribution of similarity level between NPC62290 and all drugs/candidates.
●  The right table: Most similar clinical/approved drugs (Tc>=0.56 or Top200).

Similarity Score Similarity Level Drug ID Developmental Stage
0.9493 High Similarity NPD1550 Clinical (unspecified phase)
0.9493 High Similarity NPD1552 Clinical (unspecified phase)
0.9424 High Similarity NPD1549 Phase 2
0.9122 High Similarity NPD1934 Approved
0.9116 High Similarity NPD4380 Phase 2
0.9034 High Similarity NPD4378 Clinical (unspecified phase)
0.9007 High Similarity NPD7075 Discontinued
0.9007 High Similarity NPD4381 Clinical (unspecified phase)
0.8973 High Similarity NPD1512 Approved
0.8936 High Similarity NPD1510 Phase 2
0.8933 High Similarity NPD2393 Clinical (unspecified phase)
0.8933 High Similarity NPD7096 Clinical (unspecified phase)
0.8903 High Similarity NPD6168 Clinical (unspecified phase)
0.8903 High Similarity NPD6167 Clinical (unspecified phase)
0.8903 High Similarity NPD6166 Phase 2
0.8867 High Similarity NPD6801 Discontinued
0.8836 High Similarity NPD6799 Approved
0.8836 High Similarity NPD1511 Approved
0.8786 High Similarity NPD1240 Approved
0.8734 High Similarity NPD7804 Clinical (unspecified phase)
0.8662 High Similarity NPD1607 Approved
0.8658 High Similarity NPD5403 Approved
0.8649 High Similarity NPD5401 Approved
0.8611 High Similarity NPD2796 Approved
0.8609 High Similarity NPD6599 Discontinued
0.8571 High Similarity NPD3882 Suspended
0.8562 High Similarity NPD2801 Approved
0.8509 High Similarity NPD6797 Phase 2
0.8506 High Similarity NPD8443 Clinical (unspecified phase)
0.8506 High Similarity NPD3817 Phase 2
0.8457 Intermediate Similarity NPD7251 Discontinued
0.8447 Intermediate Similarity NPD7074 Phase 3
0.8438 Intermediate Similarity NPD3818 Discontinued
0.8431 Intermediate Similarity NPD7411 Suspended
0.8405 Intermediate Similarity NPD7808 Phase 3
0.8405 Intermediate Similarity NPD4338 Clinical (unspecified phase)
0.84 Intermediate Similarity NPD7410 Clinical (unspecified phase)
0.8387 Intermediate Similarity NPD5402 Approved
0.8385 Intermediate Similarity NPD7054 Approved
0.8333 Intermediate Similarity NPD4868 Clinical (unspecified phase)
0.8333 Intermediate Similarity NPD7472 Approved
0.8231 Intermediate Similarity NPD1551 Phase 2
0.8205 Intermediate Similarity NPD7819 Suspended
0.8171 Intermediate Similarity NPD7993 Clinical (unspecified phase)
0.8138 Intermediate Similarity NPD1613 Approved
0.8138 Intermediate Similarity NPD1612 Clinical (unspecified phase)
0.8133 Intermediate Similarity NPD3750 Approved
0.8129 Intermediate Similarity NPD1547 Clinical (unspecified phase)
0.8125 Intermediate Similarity NPD6959 Discontinued
0.8121 Intermediate Similarity NPD6559 Discontinued
0.8063 Intermediate Similarity NPD5494 Approved
0.805 Intermediate Similarity NPD3749 Approved
0.8013 Intermediate Similarity NPD4628 Phase 3
0.8 Intermediate Similarity NPD970 Clinical (unspecified phase)
0.8 Intermediate Similarity NPD6859 Clinical (unspecified phase)
0.7975 Intermediate Similarity NPD7852 Clinical (unspecified phase)
0.7947 Intermediate Similarity NPD2800 Approved
0.7947 Intermediate Similarity NPD7421 Clinical (unspecified phase)
0.7902 Intermediate Similarity NPD1203 Approved
0.7891 Intermediate Similarity NPD943 Approved
0.7879 Intermediate Similarity NPD3751 Discontinued
0.7875 Intermediate Similarity NPD7768 Phase 2
0.7872 Intermediate Similarity NPD1610 Phase 2
0.7862 Intermediate Similarity NPD1465 Phase 2
0.7862 Intermediate Similarity NPD1529 Clinical (unspecified phase)
0.7842 Intermediate Similarity NPD1548 Phase 1
0.7831 Intermediate Similarity NPD5844 Phase 1
0.7821 Intermediate Similarity NPD920 Approved
0.7806 Intermediate Similarity NPD642 Clinical (unspecified phase)
0.78 Intermediate Similarity NPD3748 Approved
0.7793 Intermediate Similarity NPD1530 Clinical (unspecified phase)
0.7792 Intermediate Similarity NPD643 Clinical (unspecified phase)
0.7791 Intermediate Similarity NPD1247 Approved
0.7778 Intermediate Similarity NPD919 Approved
0.7778 Intermediate Similarity NPD1878 Clinical (unspecified phase)
0.7755 Intermediate Similarity NPD6798 Discontinued
0.7744 Intermediate Similarity NPD6232 Discontinued
0.7744 Intermediate Similarity NPD3787 Discontinued
0.7727 Intermediate Similarity NPD8090 Clinical (unspecified phase)
0.7712 Intermediate Similarity NPD1243 Approved
0.7711 Intermediate Similarity NPD7473 Discontinued
0.7697 Intermediate Similarity NPD2344 Approved
0.7682 Intermediate Similarity NPD7033 Discontinued
0.7667 Intermediate Similarity NPD6651 Approved
0.7647 Intermediate Similarity NPD4419 Clinical (unspecified phase)
0.7635 Intermediate Similarity NPD2313 Discontinued
0.7632 Intermediate Similarity NPD2935 Discontinued
0.7619 Intermediate Similarity NPD7286 Phase 2
0.7619 Intermediate Similarity NPD4908 Phase 1
0.76 Intermediate Similarity NPD7879 Clinical (unspecified phase)
0.7597 Intermediate Similarity NPD1652 Phase 2
0.759 Intermediate Similarity NPD3926 Phase 2
0.7584 Intermediate Similarity NPD6233 Phase 2
0.758 Intermediate Similarity NPD2532 Approved
0.758 Intermediate Similarity NPD2533 Approved
0.758 Intermediate Similarity NPD2534 Approved
0.7569 Intermediate Similarity NPD9717 Approved
0.7566 Intermediate Similarity NPD651 Clinical (unspecified phase)
0.7529 Intermediate Similarity NPD5953 Discontinued
0.7517 Intermediate Similarity NPD4907 Clinical (unspecified phase)
0.7516 Intermediate Similarity NPD6099 Approved
0.7516 Intermediate Similarity NPD6100 Approved
0.7514 Intermediate Similarity NPD4363 Phase 3
0.7514 Intermediate Similarity NPD4360 Phase 2
0.75 Intermediate Similarity NPD2309 Approved
0.75 Intermediate Similarity NPD6832 Phase 2
0.75 Intermediate Similarity NPD422 Phase 1
0.7483 Intermediate Similarity NPD6355 Discontinued
0.7483 Intermediate Similarity NPD230 Phase 1
0.7483 Intermediate Similarity NPD1933 Approved
0.7468 Intermediate Similarity NPD7004 Clinical (unspecified phase)
0.7451 Intermediate Similarity NPD2799 Discontinued
0.7451 Intermediate Similarity NPD1509 Clinical (unspecified phase)
0.745 Intermediate Similarity NPD3027 Phase 3
0.7407 Intermediate Similarity NPD7615 Clinical (unspecified phase)
0.74 Intermediate Similarity NPD3268 Approved
0.7399 Intermediate Similarity NPD8313 Approved
0.7399 Intermediate Similarity NPD8312 Approved
0.7391 Intermediate Similarity NPD3226 Approved
0.7389 Intermediate Similarity NPD2354 Approved
0.7389 Intermediate Similarity NPD6190 Approved
0.7379 Intermediate Similarity NPD1091 Approved
0.7371 Intermediate Similarity NPD8434 Phase 2
0.7368 Intermediate Similarity NPD5123 Clinical (unspecified phase)
0.7368 Intermediate Similarity NPD447 Suspended
0.7368 Intermediate Similarity NPD5124 Phase 1
0.7358 Intermediate Similarity NPD4662 Approved
0.7358 Intermediate Similarity NPD4661 Approved
0.7355 Intermediate Similarity NPD2346 Discontinued
0.7351 Intermediate Similarity NPD7584 Approved
0.7347 Intermediate Similarity NPD3225 Approved
0.7343 Intermediate Similarity NPD9545 Approved
0.7337 Intermediate Similarity NPD7784 Clinical (unspecified phase)
0.7329 Intermediate Similarity NPD1653 Approved
0.7317 Intermediate Similarity NPD8455 Phase 2
0.7308 Intermediate Similarity NPD6779 Approved
0.7308 Intermediate Similarity NPD2424 Discontinued
0.7308 Intermediate Similarity NPD6782 Approved
0.7308 Intermediate Similarity NPD6777 Approved
0.7308 Intermediate Similarity NPD6776 Approved
0.7308 Intermediate Similarity NPD6780 Approved
0.7308 Intermediate Similarity NPD6778 Approved
0.7308 Intermediate Similarity NPD6781 Approved
0.7297 Intermediate Similarity NPD2797 Approved
0.7285 Intermediate Similarity NPD1296 Phase 2
0.7278 Intermediate Similarity NPD3887 Approved
0.7278 Intermediate Similarity NPD7184 Clinical (unspecified phase)
0.7267 Intermediate Similarity NPD6980 Clinical (unspecified phase)
0.7262 Intermediate Similarity NPD7199 Phase 2
0.7261 Intermediate Similarity NPD2654 Approved
0.7255 Intermediate Similarity NPD1899 Clinical (unspecified phase)
0.7248 Intermediate Similarity NPD1019 Discontinued
0.7248 Intermediate Similarity NPD2798 Approved
0.7237 Intermediate Similarity NPD4062 Phase 3
0.7235 Intermediate Similarity NPD2403 Approved
0.7234 Intermediate Similarity NPD1241 Discontinued
0.7226 Intermediate Similarity NPD4308 Phase 3
0.7215 Intermediate Similarity NPD6398 Clinical (unspecified phase)
0.7211 Intermediate Similarity NPD1608 Approved
0.7211 Intermediate Similarity NPD1481 Phase 2
0.7203 Intermediate Similarity NPD9493 Approved
0.72 Intermediate Similarity NPD2861 Phase 2
0.7189 Intermediate Similarity NPD7435 Discontinued
0.7188 Intermediate Similarity NPD7390 Discontinued
0.7182 Intermediate Similarity NPD4362 Clinical (unspecified phase)
0.7182 Intermediate Similarity NPD4361 Phase 2
0.7181 Intermediate Similarity NPD3267 Approved
0.7181 Intermediate Similarity NPD3266 Approved
0.7178 Intermediate Similarity NPD5808 Clinical (unspecified phase)
0.7175 Intermediate Similarity NPD8150 Discontinued
0.7169 Intermediate Similarity NPD4288 Approved
0.7168 Intermediate Similarity NPD1729 Discontinued
0.7152 Intermediate Similarity NPD6844 Discontinued
0.7143 Intermediate Similarity NPD1201 Approved
0.7143 Intermediate Similarity NPD1535 Discovery
0.7143 Intermediate Similarity NPD4340 Discontinued
0.7135 Intermediate Similarity NPD4575 Clinical (unspecified phase)
0.7134 Intermediate Similarity NPD2355 Clinical (unspecified phase)
0.7134 Intermediate Similarity NPD1471 Phase 3
0.7134 Intermediate Similarity NPD2353 Approved
0.7126 Intermediate Similarity NPD3823 Discontinued
0.712 Intermediate Similarity NPD7501 Clinical (unspecified phase)
0.7119 Intermediate Similarity NPD8055 Clinical (unspecified phase)
0.7118 Intermediate Similarity NPD5710 Approved
0.7118 Intermediate Similarity NPD5711 Approved
0.7099 Intermediate Similarity NPD5049 Phase 3
0.7097 Intermediate Similarity NPD7697 Approved
0.7097 Intermediate Similarity NPD7698 Approved
0.7097 Intermediate Similarity NPD7696 Phase 3
0.7095 Intermediate Similarity NPD4287 Approved
0.7095 Intermediate Similarity NPD3972 Approved
0.7086 Intermediate Similarity NPD9494 Approved
0.7086 Intermediate Similarity NPD6104 Discontinued
0.7081 Intermediate Similarity NPD6143 Clinical (unspecified phase)
0.7078 Intermediate Similarity NPD4060 Phase 1
0.7073 Intermediate Similarity NPD7458 Discontinued
0.7067 Intermediate Similarity NPD1470 Approved
0.7059 Intermediate Similarity NPD3764 Approved
0.7059 Intermediate Similarity NPD7871 Phase 2
0.7059 Intermediate Similarity NPD7870 Phase 2

  Bioactivity similarity: Similar Natural Products in NPASS

Bioactivity similarity was calculated based on bioactivity descriptors of compounds. The bioactivity descriptors were calculated by a recently developed AI algorithm Chemical Checker (CC) [Nature Biotechnology, 38:1087–1096, 2020; Nature Communications, 12:3932, 2021], which evaluated bioactivity similarities at five levels:
☉ A: chemistry similarity;
☉ B: biological targets similarity;
☉ C: networks similarity;
☉ D: cell-based bioactivity similarity;
☉ E: similarity based on clinical data.

Those 5 categories of CC bioactivity descriptors were calculated and then subjected to manifold projection using UMAP algorithm, to project all NPs on a 2-Dimensional space. The current NP was highlighted with a small circle in the 2-D map. Below figures: left-to-right, A-to-E.

A: chemistry similarity
B: biological targets similarity
C: networks similarity
D: cell-based bioactivity similarity
E: similarity based on clinical data