Molecular Weight:   | 328.09 |
Volume:   | 325.865 |
LogP:   | 3.615 |
LogD:   | 2.889 |
LogS:   | -4.421 |
# Rotatable Bonds:   | 4 |
TPSA:   | 78.13 |
# H-Bond Aceptor:   | 6 |
# H-Bond Donor:   | 1 |
# Rings:   | 3 |
# Heavy Atoms:   | 6 |
QED Drug-Likeness Score:   | 0.792 |
Synthetic Accessibility Score:   | 2.148 |
Fsp3:   | 0.167 |
Lipinski Rule-of-5:   | Accepted |
Pfizer Rule:   | Accepted |
GSK Rule:   | Accepted |
BMS Rule:   | 0 |
Golden Triangle Rule:   | Accepted |
Chelating Alert:   | 0 |
PAINS Alert:   | 0 |
Caco-2 Permeability:   | -4.733 |
MDCK Permeability:   | 3.134089638479054e-05 |
Pgp-inhibitor:   | 0.933 |
Pgp-substrate:   | 0.018 |
Human Intestinal Absorption (HIA):   | 0.017 |
20% Bioavailability (F20%):   | 0.009 |
30% Bioavailability (F30%):   | 0.839 |
Blood-Brain-Barrier Penetration (BBB):   | 0.034 |
Plasma Protein Binding (PPB):   | 87.2718734741211% |
Volume Distribution (VD):   | 0.785 |
Pgp-substrate:   | 11.311453819274902% |
CYP1A2-inhibitor:   | 0.957 |
CYP1A2-substrate:   | 0.966 |
CYP2C19-inhibitor:   | 0.794 |
CYP2C19-substrate:   | 0.295 |
CYP2C9-inhibitor:   | 0.726 |
CYP2C9-substrate:   | 0.925 |
CYP2D6-inhibitor:   | 0.481 |
CYP2D6-substrate:   | 0.939 |
CYP3A4-inhibitor:   | 0.799 |
CYP3A4-substrate:   | 0.346 |
Clearance (CL):   | 6.627 |
Half-life (T1/2):   | 0.509 |
hERG Blockers:   | 0.052 |
Human Hepatotoxicity (H-HT):   | 0.171 |
Drug-inuced Liver Injury (DILI):   | 0.889 |
AMES Toxicity:   | 0.484 |
Rat Oral Acute Toxicity:   | 0.063 |
Maximum Recommended Daily Dose:   | 0.451 |
Skin Sensitization:   | 0.649 |
Carcinogencity:   | 0.039 |
Eye Corrosion:   | 0.004 |
Eye Irritation:   | 0.471 |
Respiratory Toxicity:   | 0.58 |
Natural Product ID:   | NPC195202 |
Common Name*:   | 7,3',4'-Tri-O-Methylluteolin |
IUPAC Name:   | 2-(3,4-dimethoxyphenyl)-5-hydroxy-7-methoxychromen-4-one |
Synonyms:   | |
Standard InCHIKey:   | HIXDQWDOVZUNNA-UHFFFAOYSA-N |
Standard InCHI:   | InChI=1S/C18H16O6/c1-21-11-7-12(19)18-13(20)9-15(24-17(18)8-11)10-4-5-14(22-2)16(6-10)23-3/h4-9,19H,1-3H3 |
SMILES:   | COc1cc(O)c2c(c1)oc(cc2=O)c1ccc(c(c1)OC)OC |
Synthetic Gene Cluster:   | n.a. |
ChEMBL Identifier:   | CHEMBL468876 |
PubChem CID:   |
5272653 |
Chemical Classification**:   |
|
*Note: the InCHIKey will be temporarily assigned as the "Common Name" if no IUPAC name or alternative short name is available.
**Note: the Chemical Classification was calculated by NPClassifier Version 1.5. Reference: PMID:34662515.
Organism ID | Organism Name | Taxonomy Level | Family | SuperKingdom | Isolation Part | Collection Location | Collection Time | Reference |
---|---|---|---|---|---|---|---|---|
NPO33004 | lethedon tannaensis | Species | Thymelaeaceae | Eukaryota | n.a. | n.a. | n.a. |
PMID[10075750] |
NPO29103 | Spongia matamata | Species | Spongiidae | Eukaryota | n.a. | n.a. | n.a. |
PMID[10075761] |
NPO28014 | Garcinia gaudichaudii | Species | Clusiaceae | Eukaryota | n.a. | bark | n.a. |
PMID[11101460] |
NPO22900 | Orthosiphon stamineus | Species | Lamiaceae | Eukaryota | n.a. | n.a. | n.a. |
PMID[11374950] |
NPO19451 | Salvia prionitis | Species | Lamiaceae | Eukaryota | n.a. | n.a. | n.a. |
PMID[11473439] |
NPO19451 | Salvia prionitis | Species | Lamiaceae | Eukaryota | n.a. | n.a. | n.a. |
PMID[12141863] |
NPO22900 | Orthosiphon stamineus | Species | Lamiaceae | Eukaryota | n.a. | Indonesia | n.a. |
PMID[12467611] |
NPO29463 | Pogostemon cablin | Species | Lamiaceae | Eukaryota | n.a. | stem | n.a. |
PMID[12575075] |
NPO29463 | Pogostemon cablin | Species | Lamiaceae | Eukaryota | n.a. | leaf | n.a. |
PMID[12575075] |
NPO22900 | Orthosiphon stamineus | Species | Lamiaceae | Eukaryota | aerial parts | Bangdung, Indonesia | 2000-Aug |
PMID[12608860] |
NPO27888 | Sarcococca saligna | Species | Buxaceae | Eukaryota | n.a. | n.a. | n.a. |
PMID[14584959] |
NPO27888 | Sarcococca saligna | Species | Buxaceae | Eukaryota | n.a. | n.a. | n.a. |
PMID[14643329] |
NPO22900 | Orthosiphon stamineus | Species | Lamiaceae | Eukaryota | n.a. | Taiwan | n.a. |
PMID[15104497] |
NPO29463 | Pogostemon cablin | Species | Lamiaceae | Eukaryota | n.a. | whole plant | n.a. |
PMID[15577255] |
NPO27718 | Peperomia dindygulensis | Species | Piperaceae | Eukaryota | whole plant | Yunnan Province, China | 2002-FEB |
PMID[16309318] |
NPO27718 | Peperomia dindygulensis | Species | Piperaceae | Eukaryota | whole plant | Yunnan Province, China | 2002-FEB |
PMID[16724842] |
NPO21944 | Laurencia mariannensis | Species | Rhodomelaceae | Eukaryota | n.a. | n.a. | n.a. |
PMID[18076141] |
NPO16665 | Tephrosia semiglabra | Species | Geometridae | Eukaryota | n.a. | n.a. | n.a. |
PMID[2089123] |
NPO9756 | Daphne genkwa | Species | Thymelaeaceae | Eukaryota | n.a. | flower | n.a. |
PMID[21916433] |
NPO5877 | Morus yunnanensis | Species | Moraceae | Eukaryota | n.a. | n.a. | n.a. |
PMID[22165973] |
NPO9756 | Daphne genkwa | Species | Thymelaeaceae | Eukaryota | flower buds | n.a. | n.a. |
PMID[23558238] |
NPO19152 | Empetrum nigrum | Species | Ericaceae | Eukaryota | n.a. | n.a. | n.a. |
PMID[26473275] |
NPO9756 | Daphne genkwa | Species | Thymelaeaceae | Eukaryota | n.a. | n.a. | n.a. |
PMID[27228307] |
NPO23000 | Zephyranthes carinata | Species | Amaryllidaceae | Eukaryota | Whole Plants | n.a. | n.a. |
PMID[28898076] |
NPO29463 | Pogostemon cablin | Species | Lamiaceae | Eukaryota | n.a. | n.a. | n.a. |
PMID[30188125] |
NPO9756 | Daphne genkwa | Species | Thymelaeaceae | Eukaryota | Roots | n.a. | n.a. |
PMID[31150241] |
NPO3549 | Euonymus maackii | Species | Celastraceae | Eukaryota | Seeds | n.a. | n.a. |
PMID[31713425] |
NPO9756 | Daphne genkwa | Species | Thymelaeaceae | Eukaryota | n.a. | n.a. | n.a. |
PMID[31860304] |
NPO9756 | Daphne genkwa | Species | Thymelaeaceae | Eukaryota | n.a. | n.a. | n.a. |
PMID[32223193] |
NPO33004 | lethedon tannaensis | Species | Thymelaeaceae | Eukaryota | n.a. | n.a. | n.a. |
PMID[8759170] |
NPO27888 | Sarcococca saligna | Species | Buxaceae | Eukaryota | n.a. | n.a. | n.a. |
PMID[9548847] |
NPO23226 | Satureja montana | Species | Lamiaceae | Eukaryota | Plant | n.a. | n.a. | Database[FooDB] |
NPO19152 | Empetrum nigrum | Species | Ericaceae | Eukaryota | n.a. | n.a. | Database[FooDB] | |
NPO22500 | Stephania dielsiana | Species | Menispermaceae | Eukaryota | n.a. | n.a. | n.a. | Database[HerDing] |
NPO21807 | Lindera umbellata | Species | Lauraceae | Eukaryota | n.a. | n.a. | n.a. | Database[HerDing] |
NPO27842 | Gentiana makinoi | Species | Gentianaceae | Eukaryota | n.a. | n.a. | n.a. | Database[HerDing] |
NPO19929 | Jateorhiza palmata | Species | Menispermaceae | Eukaryota | n.a. | n.a. | n.a. | Database[HerDing] |
NPO22661 | Pinus aristata | Species | Pinaceae | Eukaryota | n.a. | n.a. | n.a. | Database[HerDing] |
NPO29463 | Pogostemon cablin | Species | Lamiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[HerDing] |
NPO28939 | Piptanthus nepalensis | Species | Fabaceae | Eukaryota | n.a. | n.a. | n.a. | Database[HerDing] |
NPO27888 | Sarcococca saligna | Species | Buxaceae | Eukaryota | n.a. | n.a. | n.a. | Database[HerDing] |
NPO19451 | Salvia prionitis | Species | Lamiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[HerDing] |
NPO16710 | Pandanus tectorius | Species | Pandanaceae | Eukaryota | n.a. | n.a. | n.a. | Database[HerDing] |
NPO23141 | Angelica ursina | Species | Apiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[HerDing] |
NPO21600 | Aconitum variegatum | Species | Ranunculaceae | Eukaryota | n.a. | n.a. | n.a. | Database[HerDing] |
NPO22900 | Orthosiphon stamineus | Species | Lamiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[HerDing] |
NPO9756 | Daphne genkwa | Species | Thymelaeaceae | Eukaryota | n.a. | n.a. | n.a. | Database[HerDing] |
NPO19152 | Empetrum nigrum | Species | Ericaceae | Eukaryota | n.a. | n.a. | Database[Phenol-Explorer] | |
NPO19152 | Empetrum nigrum | Species | Ericaceae | Eukaryota | Fruits | n.a. | Database[Phenol-Explorer] | |
NPO23226 | Satureja montana | Species | Lamiaceae | Eukaryota | n.a. | n.a. | Database[Phenol-Explorer] | |
NPO13304 | Piper spp. | Species | Piperaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO28014 | Garcinia gaudichaudii | Species | Clusiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO27842 | Gentiana makinoi | Species | Gentianaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO28939 | Piptanthus nepalensis | Species | Fabaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO22500 | Stephania dielsiana | Species | Menispermaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO22900 | Orthosiphon stamineus | Species | Lamiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO22661 | Pinus aristata | Species | Pinaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO19451 | Salvia prionitis | Species | Lamiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO23141 | Angelica ursina | Species | Apiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO22462 | Chlorophytum malayense | Species | Asparagaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO29463 | Pogostemon cablin | Species | Lamiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO16710 | Pandanus tectorius | Species | Pandanaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO9756 | Daphne genkwa | Species | Thymelaeaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO21881 | Stephania succifera | Species | Menispermaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO21807 | Lindera umbellata | Species | Lauraceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO26562 | Salvia spp. | Species | Lamiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO2116 | Arnica spp. | Species | Asteraceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO21600 | Aconitum variegatum | Species | Ranunculaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO19929 | Jateorhiza palmata | Species | Menispermaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO27888 | Sarcococca saligna | Species | Buxaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO3549 | Euonymus maackii | Species | Celastraceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO22071 | Gentiana olivieri | Species | Gentianaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO16710 | Pandanus tectorius | Species | Pandanaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCM_Taiwan] |
NPO29463 | Pogostemon cablin | Species | Lamiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCM_Taiwan] |
NPO19929 | Jateorhiza palmata | Species | Menispermaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCM_Taiwan] |
NPO22900 | Orthosiphon stamineus | Species | Lamiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCM_Taiwan] |
NPO9756 | Daphne genkwa | Species | Thymelaeaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCM_Taiwan] |
NPO21600 | Aconitum variegatum | Species | Ranunculaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCM_Taiwan] |
NPO19451 | Salvia prionitis | Species | Lamiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCM_Taiwan] |
NPO28939 | Piptanthus nepalensis | Species | Fabaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCM_Taiwan] |
NPO21807 | Lindera umbellata | Species | Lauraceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCM_Taiwan] |
NPO29463 | Pogostemon cablin | Species | Lamiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TM-MC] |
NPO9756 | Daphne genkwa | Species | Thymelaeaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TM-MC] |
NPO10353 | Rauvolfia tetraphylla | Species | Apocynaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO16665 | Tephrosia semiglabra | Species | Geometridae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO19929 | Jateorhiza palmata | Species | Menispermaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO21545 | Maytenus guianensis | Species | Celastraceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO13728 | Metanarthecium luteoviride | Species | Nartheciaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO23101 | Ircinia aruensis | Species | Irciniidae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO22137 | Vernonia serratuloides | Species | Asteraceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO23226 | Satureja montana | Species | Lamiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO20584 | Cheilanthes fragrans | Species | Pteridaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO27135 | Tubularia larynx | Species | Tubulariidae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO22071 | Gentiana olivieri | Species | Gentianaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO14664 | Stevia salicifolia | Species | Asteraceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO21600 | Aconitum variegatum | Species | Ranunculaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO21680 | Saussurea triangulata | Species | Asteraceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO19152 | Empetrum nigrum | Species | Ericaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO18852 | Plenckia populnea | Species | Celastraceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO22500 | Stephania dielsiana | Species | Menispermaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO22518 | Gnetum cleistostachyum | Species | Gnetaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO984 | Hippocrepis emerus | Species | Fabaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO20726 | Ophioplocus japonicus | Species | Ophiolepididae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO25969 | Aspergillus nomius | Species | Aspergillaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO27401 | Aniba riparia | Species | Lauraceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO16710 | Pandanus tectorius | Species | Pandanaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO20100 | Ephedra lomatolepis | Species | Ephedraceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO22015 | Clausena indica | Species | Rutaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO21344 | Fadogia agrestis | Species | Rubiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO27888 | Sarcococca saligna | Species | Buxaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO22773 | Teucrium alyssifolium | Species | Lamiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO28133 | Geigeria filifolia | Species | Asteraceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO22952 | Senecio grandiflorus | Species | Asteraceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO27184 | Bonellia macrocarpa | Species | Primulaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO22405 | Litsea monopetala | Species | Lauraceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO28870 | Clausena lenis | Species | Rutaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO27718 | Peperomia dindygulensis | Species | Piperaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO22395 | Ardisia macrocarpa | Species | Primulaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO22717 | Pinus thunbergii | Species | Pinaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO22197 | Eriogaster lanestris | Species | Lasiocampidae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO21807 | Lindera umbellata | Species | Lauraceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO11524 | Macrotomia ugamensis | Species | Boraginaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO13234 | Gyalolechia fulgida | Species | Teloschistaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO9756 | Daphne genkwa | Species | Thymelaeaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO27439 | Letharia vulpina | Species | Parmeliaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO23000 | Zephyranthes carinata | Species | Amaryllidaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO28808 | Piptanthus mongolicus | Species | Fabaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO27953 | Eugenia formosa | Species | Myrtaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO29013 | Annulohypoxylon cohaerens | Species | Xylariaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO5877 | Morus yunnanensis | Species | Moraceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO21384 | Tetraria capillaris | Species | Cyperaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO20964 | Picradeniopsis oppositifolia | Species | Asteraceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO17401 | Kopsia lapidilecta | Species | Apocynaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO22462 | Chlorophytum malayense | Species | Asparagaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO22661 | Pinus aristata | Species | Pinaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO28939 | Piptanthus nepalensis | Species | Fabaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO28974 | Smilax ornata | Species | Staphylinidae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO21944 | Laurencia mariannensis | Species | Rhodomelaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO3549 | Euonymus maackii | Species | Celastraceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO28829 | Pelvetia wrightii | Species | Fucaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO16275 | Pterocaulon rugosum | Species | Asteraceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO23183 | Pinus halepensis | Species | Pinaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO29463 | Pogostemon cablin | Species | Lamiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO21881 | Stephania succifera | Species | Menispermaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO22900 | Orthosiphon stamineus | Species | Lamiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO17547 | Dryopteris arguta | Species | Dryopteridaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO7320 | Nicotiana gossei | Species | Solanaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO19451 | Salvia prionitis | Species | Lamiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO22911 | Enterococcus faecalis | Species | Enterococcaceae | Bacteria | n.a. | n.a. | n.a. | Database[UNPD] |
NPO21534 | Ostrya carpinifolia | Species | Betulaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO29103 | Spongia matamata | Species | Spongiidae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO14529 | Asterias rubens | Species | Asteriidae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO11024 | Bellardia viscosa | Species | Orobanchaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO29194 | Harziella entomophila | n.a. | n.a. | n.a. | n.a. | n.a. | n.a. | Database[UNPD] |
NPO19590 | Daedaleopsis tricolor | Species | Coriolaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO17271 | Aegialitis annulata | Species | Plumbaginaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO27362 | Hypericum elodes | Species | Hypericaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO21140 | Igernella notabilis | Species | Dictyodendrillidae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO23062 | Melibe leonina | Species | Dendronotidae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO27842 | Gentiana makinoi | Species | Gentianaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO29402 | Launaea arborescens | Species | Asteraceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO28066 | Aloe speciosa | Species | Xanthorrhoeaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO26540 | Echinopsis spachiana | Species | Cactaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO29157 | Reichardia gaditana | Species | Asteraceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO21745 | Phleum africanum | Species | Poaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO23141 | Angelica ursina | Species | Apiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO28014 | Garcinia gaudichaudii | Species | Clusiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
☑ Note for Reference:
In addition to directly collecting NP source organism data from primary literature (where reference will provided as NCBI PMID or DOI links), NPASS also integrated them from below databases:
☉ UNPD: Universal Natural Products Database [PMID: 23638153].
☉ StreptomeDB: a database of streptomycetes natural products [PMID: 33051671].
☉ TM-MC: a database of medicinal materials and chemical compounds in Northeast Asian traditional medicine [PMID: 26156871].
☉ TCM@Taiwan: a Traditional Chinese Medicine database [PMID: 21253603].
☉ TCMID: a Traditional Chinese Medicine database [PMID: 29106634].
☉ TCMSP: The traditional Chinese medicine systems pharmacology database and analysis platform [PMID: 24735618].
☉ HerDing: a herb recommendation system to treat diseases using genes and chemicals [PMID: 26980517].
☉ MetaboLights: a metabolomics database [PMID: 27010336].
☉ FooDB: a database of constituents, chemistry and biology of food species [www.foodb.ca].
Organism ID | NP ID | Organism Material Preparation | Organism Part | NP Quantity (Standard) | NP Quantity (Minimum) | NP Quantity (Maximum) | Quantity Unit | Reference |
---|
☑ Note for Reference:
In addition to directly collecting NP quantitative data from primary literature (where reference will provided as NCBI PMID or DOI links), NPASS also integrated NP quantitative records for specific NP domains (e.g., NPS from foods or herbs) from domain-specific databases. These databases include:
☉ DUKE: Dr. Duke's Phytochemical and Ethnobotanical Databases.
☉ PHENOL EXPLORER: is the first comprehensive database on polyphenol content in foods [PMID: 24103452], its homepage can be accessed at here.
☉ FooDB: a database of constituents, chemistry and biology of food species [www.foodb.ca].
Target ID | Target Type | Target Name | Target Organism | Activity Type | Activity Relation | Value | Unit | Reference |
---|---|---|---|---|---|---|---|---|
NPT91 | Cell Line | KB | Homo sapiens | IC50 | = | 19.4 | ug.mL-1 | PMID[511798] |
NPT83 | Cell Line | MCF7 | Homo sapiens | Activity | = | 71.3 | % | PMID[511799] |
NPT83 | Cell Line | MCF7 | Homo sapiens | Activity | = | 13.0 | % | PMID[511799] |
NPT65 | Cell Line | HepG2 | Homo sapiens | IC50 | = | 15000.0 | nM | PMID[511799] |
NPT189 | Cell Line | Vero | Chlorocebus aethiops | IC50 | = | 125000.0 | nM | PMID[511799] |
NPT1374 | Cell Line | WI-38 | Homo sapiens | IC50 | = | 105000.0 | nM | PMID[511799] |
NPT83 | Cell Line | MCF7 | Homo sapiens | IC50 | = | 10000.0 | nM | PMID[511799] |
NPT885 | Cell Line | PBL | Activity | = | 65.0 | % | PMID[511799] | |
NPT20529 | NON-MOLECULAR | NON-PROTEIN TARGET | n.a. | Activity | = | 45.8 | % | PMID[511799] |
NPT21851 | SINGLE PROTEIN | Dihydroorotate dehydrogenase (fumarate) | Leishmania major | IC50 | = | 217000.0 | nM | PMID[511800] |
NPT21851 | SINGLE PROTEIN | Dihydroorotate dehydrogenase (fumarate) | Leishmania major | IC50 | = | 199526.23 | nM | PMID[511800] |
NPT580 | Organism | Trypanosoma cruzi | Trypanosoma cruzi | IC50 | = | 217300.0 | nM | PMID[511800] |
☑ Note for Activity Records:
☉ The quantitative biological activities were primarily integrated from ChEMBL (Version-30) database and were also directly collected from PubMed literature. PubMed PMID was provided as the reference link for each activity record.
Top-200 similar NPs were calculated against the active-NP-set (includes 4,3285 NPs with experimentally-derived bioactivity available in NPASS)
Similarity level is defined by Tanimoto coefficient (Tc) between two molecules. Tc lies between [0, 1] where '1' indicates the highest similarity. What is Tanimoto coefficient
●  The left chart: Distribution of similarity level between NPC195202 and all remaining natural products in the NPASS database.
●  The right table: Most similar natural products (Tc>=0.56 or Top200).
Similarity Score | Similarity Level | Natural Product ID |
---|---|---|
0.9929 | High Similarity | NPC62536 |
0.9929 | High Similarity | NPC12200 |
0.9929 | High Similarity | NPC33265 |
0.986 | High Similarity | NPC50728 |
0.986 | High Similarity | NPC166753 |
0.9792 | High Similarity | NPC236769 |
0.9792 | High Similarity | NPC226973 |
0.9792 | High Similarity | NPC208043 |
0.9792 | High Similarity | NPC308451 |
0.979 | High Similarity | NPC137062 |
0.979 | High Similarity | NPC177298 |
0.979 | High Similarity | NPC159103 |
0.979 | High Similarity | NPC328119 |
0.979 | High Similarity | NPC223579 |
0.979 | High Similarity | NPC48479 |
0.979 | High Similarity | NPC183950 |
0.979 | High Similarity | NPC287101 |
0.979 | High Similarity | NPC52005 |
0.9724 | High Similarity | NPC39732 |
0.9724 | High Similarity | NPC60972 |
0.9722 | High Similarity | NPC306821 |
0.9722 | High Similarity | NPC219330 |
0.972 | High Similarity | NPC120464 |
0.972 | High Similarity | NPC261548 |
0.9658 | High Similarity | NPC47781 |
0.9658 | High Similarity | NPC183878 |
0.9658 | High Similarity | NPC160951 |
0.9658 | High Similarity | NPC86485 |
0.9658 | High Similarity | NPC236223 |
0.9658 | High Similarity | NPC270620 |
0.9658 | High Similarity | NPC69394 |
0.9658 | High Similarity | NPC22519 |
0.9658 | High Similarity | NPC255350 |
0.9658 | High Similarity | NPC78326 |
0.9658 | High Similarity | NPC145379 |
0.9658 | High Similarity | NPC176775 |
0.9658 | High Similarity | NPC179126 |
0.9658 | High Similarity | NPC231018 |
0.9658 | High Similarity | NPC274327 |
0.9655 | High Similarity | NPC252933 |
0.9655 | High Similarity | NPC76376 |
0.9655 | High Similarity | NPC200740 |
0.9655 | High Similarity | NPC54394 |
0.9655 | High Similarity | NPC125062 |
0.965 | High Similarity | NPC108406 |
0.9645 | High Similarity | NPC70853 |
0.9645 | High Similarity | NPC9966 |
0.9592 | High Similarity | NPC20830 |
0.9592 | High Similarity | NPC183597 |
0.9592 | High Similarity | NPC50715 |
0.9592 | High Similarity | NPC227325 |
0.9592 | High Similarity | NPC163780 |
0.9592 | High Similarity | NPC196439 |
0.9592 | High Similarity | NPC201136 |
0.9592 | High Similarity | NPC256612 |
0.9592 | High Similarity | NPC128863 |
0.9592 | High Similarity | NPC92659 |
0.9592 | High Similarity | NPC213622 |
0.9592 | High Similarity | NPC146165 |
0.9592 | High Similarity | NPC167815 |
0.9592 | High Similarity | NPC4455 |
0.9592 | High Similarity | NPC2476 |
0.9592 | High Similarity | NPC189960 |
0.9592 | High Similarity | NPC138360 |
0.9592 | High Similarity | NPC280339 |
0.9592 | High Similarity | NPC32557 |
0.9589 | High Similarity | NPC162313 |
0.9589 | High Similarity | NPC71334 |
0.9589 | High Similarity | NPC156222 |
0.9589 | High Similarity | NPC301123 |
0.9589 | High Similarity | NPC82325 |
0.9589 | High Similarity | NPC275836 |
0.9589 | High Similarity | NPC188203 |
0.9589 | High Similarity | NPC55205 |
0.9589 | High Similarity | NPC120163 |
0.9589 | High Similarity | NPC83508 |
0.9589 | High Similarity | NPC241498 |
0.9589 | High Similarity | NPC198826 |
0.9589 | High Similarity | NPC187498 |
0.9589 | High Similarity | NPC57030 |
0.9589 | High Similarity | NPC301323 |
0.9589 | High Similarity | NPC100887 |
0.9589 | High Similarity | NPC212678 |
0.9589 | High Similarity | NPC222830 |
0.9589 | High Similarity | NPC131624 |
0.9589 | High Similarity | NPC239128 |
0.9589 | High Similarity | NPC293183 |
0.9589 | High Similarity | NPC25270 |
0.9589 | High Similarity | NPC279989 |
0.9589 | High Similarity | NPC471982 |
0.9589 | High Similarity | NPC256283 |
0.9589 | High Similarity | NPC275722 |
0.9586 | High Similarity | NPC338131 |
0.9577 | High Similarity | NPC113089 |
0.9574 | High Similarity | NPC29536 |
0.9527 | High Similarity | NPC49824 |
0.9527 | High Similarity | NPC265511 |
0.9527 | High Similarity | NPC178854 |
0.9524 | High Similarity | NPC276409 |
0.9524 | High Similarity | NPC162351 |
0.9524 | High Similarity | NPC18727 |
0.9524 | High Similarity | NPC75279 |
0.9524 | High Similarity | NPC246204 |
0.9524 | High Similarity | NPC472915 |
0.9524 | High Similarity | NPC280937 |
0.9524 | High Similarity | NPC250822 |
0.9524 | High Similarity | NPC58382 |
0.9521 | High Similarity | NPC133953 |
0.9521 | High Similarity | NPC28274 |
0.9521 | High Similarity | NPC117579 |
0.9521 | High Similarity | NPC50403 |
0.9517 | High Similarity | NPC87125 |
0.9517 | High Similarity | NPC270465 |
0.951 | High Similarity | NPC136278 |
0.9507 | High Similarity | NPC119663 |
0.9463 | High Similarity | NPC224137 |
0.9463 | High Similarity | NPC189179 |
0.9463 | High Similarity | NPC93376 |
0.9463 | High Similarity | NPC75215 |
0.9463 | High Similarity | NPC470402 |
0.9463 | High Similarity | NPC110070 |
0.9463 | High Similarity | NPC183 |
0.9463 | High Similarity | NPC183851 |
0.9463 | High Similarity | NPC227192 |
0.9463 | High Similarity | NPC63454 |
0.9463 | High Similarity | NPC101830 |
0.9463 | High Similarity | NPC473272 |
0.9463 | High Similarity | NPC476981 |
0.9463 | High Similarity | NPC203891 |
0.9463 | High Similarity | NPC284820 |
0.9459 | High Similarity | NPC44079 |
0.9459 | High Similarity | NPC26227 |
0.9459 | High Similarity | NPC234255 |
0.9459 | High Similarity | NPC472909 |
0.9459 | High Similarity | NPC255807 |
0.9459 | High Similarity | NPC201451 |
0.9459 | High Similarity | NPC208197 |
0.9459 | High Similarity | NPC37392 |
0.9459 | High Similarity | NPC31018 |
0.9459 | High Similarity | NPC226025 |
0.9456 | High Similarity | NPC477231 |
0.9456 | High Similarity | NPC123886 |
0.9456 | High Similarity | NPC219582 |
0.9456 | High Similarity | NPC142540 |
0.9456 | High Similarity | NPC302950 |
0.9456 | High Similarity | NPC134677 |
0.9456 | High Similarity | NPC236637 |
0.9456 | High Similarity | NPC472912 |
0.9456 | High Similarity | NPC257648 |
0.9452 | High Similarity | NPC88804 |
0.9452 | High Similarity | NPC188871 |
0.9452 | High Similarity | NPC149127 |
0.9452 | High Similarity | NPC184136 |
0.9452 | High Similarity | NPC286342 |
0.9452 | High Similarity | NPC3825 |
0.9448 | High Similarity | NPC119059 |
0.9444 | High Similarity | NPC310259 |
0.9444 | High Similarity | NPC14958 |
0.9444 | High Similarity | NPC40818 |
0.9444 | High Similarity | NPC106461 |
0.9444 | High Similarity | NPC110639 |
0.9444 | High Similarity | NPC215932 |
0.9444 | High Similarity | NPC12377 |
0.9441 | High Similarity | NPC279121 |
0.94 | High Similarity | NPC4481 |
0.94 | High Similarity | NPC22472 |
0.94 | High Similarity | NPC476410 |
0.94 | High Similarity | NPC18772 |
0.94 | High Similarity | NPC172202 |
0.94 | High Similarity | NPC176300 |
0.94 | High Similarity | NPC19687 |
0.94 | High Similarity | NPC105242 |
0.94 | High Similarity | NPC288669 |
0.94 | High Similarity | NPC7846 |
0.94 | High Similarity | NPC261004 |
0.94 | High Similarity | NPC25495 |
0.94 | High Similarity | NPC115798 |
0.94 | High Similarity | NPC9609 |
0.94 | High Similarity | NPC18607 |
0.94 | High Similarity | NPC143828 |
0.94 | High Similarity | NPC191459 |
0.94 | High Similarity | NPC300943 |
0.94 | High Similarity | NPC152166 |
0.94 | High Similarity | NPC253634 |
0.94 | High Similarity | NPC204854 |
0.94 | High Similarity | NPC130894 |
0.94 | High Similarity | NPC284127 |
0.9396 | High Similarity | NPC98661 |
0.9396 | High Similarity | NPC55619 |
0.9396 | High Similarity | NPC247017 |
0.9396 | High Similarity | NPC245546 |
0.9396 | High Similarity | NPC291878 |
0.9396 | High Similarity | NPC471985 |
0.9396 | High Similarity | NPC200388 |
0.9396 | High Similarity | NPC278778 |
0.9396 | High Similarity | NPC474520 |
0.9396 | High Similarity | NPC35038 |
0.9396 | High Similarity | NPC266960 |
0.9396 | High Similarity | NPC43243 |
0.9396 | High Similarity | NPC292107 |
Similarity level is defined by Tanimoto coefficient (Tc) between two molecules.
●  The left chart: Distribution of similarity level between NPC195202 and all drugs/candidates.
●  The right table: Most similar clinical/approved drugs (Tc>=0.56 or Top200).
Similarity Score | Similarity Level | Drug ID | Developmental Stage |
---|---|---|---|
0.9658 | High Similarity | NPD2801 | Approved |
0.9456 | High Similarity | NPD1934 | Approved |
0.9441 | High Similarity | NPD1511 | Approved |
0.931 | High Similarity | NPD1512 | Approved |
0.9262 | High Similarity | NPD2393 | Clinical (unspecified phase) |
0.92 | High Similarity | NPD3817 | Phase 2 |
0.9139 | High Similarity | NPD3882 | Suspended |
0.911 | High Similarity | NPD4378 | Clinical (unspecified phase) |
0.8974 | High Similarity | NPD6167 | Clinical (unspecified phase) |
0.8974 | High Similarity | NPD6168 | Clinical (unspecified phase) |
0.8974 | High Similarity | NPD6166 | Phase 2 |
0.8924 | High Similarity | NPD7054 | Approved |
0.8868 | High Similarity | NPD7472 | Approved |
0.8861 | High Similarity | NPD3818 | Discontinued |
0.8759 | High Similarity | NPD1552 | Clinical (unspecified phase) |
0.8759 | High Similarity | NPD1550 | Clinical (unspecified phase) |
0.875 | High Similarity | NPD1510 | Phase 2 |
0.875 | High Similarity | NPD7074 | Phase 3 |
0.8704 | High Similarity | NPD7808 | Phase 3 |
0.8699 | High Similarity | NPD1549 | Phase 2 |
0.8696 | High Similarity | NPD6797 | Phase 2 |
0.869 | High Similarity | NPD2796 | Approved |
0.8684 | High Similarity | NPD4380 | Phase 2 |
0.8642 | High Similarity | NPD7251 | Discontinued |
0.8608 | High Similarity | NPD6232 | Discontinued |
0.8601 | High Similarity | NPD1240 | Approved |
0.86 | High Similarity | NPD7410 | Clinical (unspecified phase) |
0.8599 | High Similarity | NPD5494 | Approved |
0.859 | High Similarity | NPD4381 | Clinical (unspecified phase) |
0.8589 | High Similarity | NPD4338 | Clinical (unspecified phase) |
0.8562 | High Similarity | NPD7473 | Discontinued |
0.8533 | High Similarity | NPD6799 | Approved |
0.8526 | High Similarity | NPD4868 | Clinical (unspecified phase) |
0.8483 | Intermediate Similarity | NPD1607 | Approved |
0.8471 | Intermediate Similarity | NPD7075 | Discontinued |
0.8446 | Intermediate Similarity | NPD970 | Clinical (unspecified phase) |
0.8397 | Intermediate Similarity | NPD7819 | Suspended |
0.8397 | Intermediate Similarity | NPD7096 | Clinical (unspecified phase) |
0.8344 | Intermediate Similarity | NPD8443 | Clinical (unspecified phase) |
0.8333 | Intermediate Similarity | NPD6801 | Discontinued |
0.8269 | Intermediate Similarity | NPD7411 | Suspended |
0.8232 | Intermediate Similarity | NPD7804 | Clinical (unspecified phase) |
0.8232 | Intermediate Similarity | NPD5844 | Phase 1 |
0.8228 | Intermediate Similarity | NPD5402 | Approved |
0.8219 | Intermediate Similarity | NPD943 | Approved |
0.8212 | Intermediate Similarity | NPD3750 | Approved |
0.821 | Intermediate Similarity | NPD3926 | Phase 2 |
0.8205 | Intermediate Similarity | NPD6599 | Discontinued |
0.8199 | Intermediate Similarity | NPD6959 | Discontinued |
0.8199 | Intermediate Similarity | NPD1247 | Approved |
0.8187 | Intermediate Similarity | NPD919 | Approved |
0.8165 | Intermediate Similarity | NPD1465 | Phase 2 |
0.8163 | Intermediate Similarity | NPD447 | Suspended |
0.8129 | Intermediate Similarity | NPD5403 | Approved |
0.8129 | Intermediate Similarity | NPD6980 | Clinical (unspecified phase) |
0.8082 | Intermediate Similarity | NPD6859 | Clinical (unspecified phase) |
0.8069 | Intermediate Similarity | NPD1529 | Clinical (unspecified phase) |
0.8067 | Intermediate Similarity | NPD2935 | Discontinued |
0.8067 | Intermediate Similarity | NPD1551 | Phase 2 |
0.8026 | Intermediate Similarity | NPD2800 | Approved |
0.8024 | Intermediate Similarity | NPD7993 | Clinical (unspecified phase) |
0.8 | Intermediate Similarity | NPD5401 | Approved |
0.8 | Intermediate Similarity | NPD1530 | Clinical (unspecified phase) |
0.7976 | Intermediate Similarity | NPD6559 | Discontinued |
0.7973 | Intermediate Similarity | NPD1613 | Approved |
0.7973 | Intermediate Similarity | NPD1612 | Clinical (unspecified phase) |
0.795 | Intermediate Similarity | NPD7768 | Phase 2 |
0.7939 | Intermediate Similarity | NPD7852 | Clinical (unspecified phase) |
0.7935 | Intermediate Similarity | NPD6143 | Clinical (unspecified phase) |
0.7919 | Intermediate Similarity | NPD230 | Phase 1 |
0.7919 | Intermediate Similarity | NPD1933 | Approved |
0.7908 | Intermediate Similarity | NPD7421 | Clinical (unspecified phase) |
0.7901 | Intermediate Similarity | NPD3749 | Approved |
0.7891 | Intermediate Similarity | NPD3027 | Phase 3 |
0.7885 | Intermediate Similarity | NPD2532 | Approved |
0.7885 | Intermediate Similarity | NPD2534 | Approved |
0.7885 | Intermediate Similarity | NPD2533 | Approved |
0.7881 | Intermediate Similarity | NPD3748 | Approved |
0.7857 | Intermediate Similarity | NPD1878 | Clinical (unspecified phase) |
0.7829 | Intermediate Similarity | NPD6099 | Approved |
0.7829 | Intermediate Similarity | NPD6100 | Approved |
0.7792 | Intermediate Similarity | NPD1243 | Approved |
0.7785 | Intermediate Similarity | NPD920 | Approved |
0.7778 | Intermediate Similarity | NPD2344 | Approved |
0.7763 | Intermediate Similarity | NPD651 | Clinical (unspecified phase) |
0.7758 | Intermediate Similarity | NPD7199 | Phase 2 |
0.7748 | Intermediate Similarity | NPD6651 | Approved |
0.7742 | Intermediate Similarity | NPD4628 | Phase 3 |
0.774 | Intermediate Similarity | NPD1203 | Approved |
0.7724 | Intermediate Similarity | NPD4379 | Clinical (unspecified phase) |
0.7719 | Intermediate Similarity | NPD4419 | Clinical (unspecified phase) |
0.7718 | Intermediate Similarity | NPD2313 | Discontinued |
0.7688 | Intermediate Similarity | NPD3226 | Approved |
0.7676 | Intermediate Similarity | NPD1548 | Phase 1 |
0.7667 | Intermediate Similarity | NPD7501 | Clinical (unspecified phase) |
0.7665 | Intermediate Similarity | NPD7184 | Clinical (unspecified phase) |
0.7658 | Intermediate Similarity | NPD642 | Clinical (unspecified phase) |
0.7647 | Intermediate Similarity | NPD2799 | Discontinued |
0.7647 | Intermediate Similarity | NPD1509 | Clinical (unspecified phase) |
0.7643 | Intermediate Similarity | NPD643 | Clinical (unspecified phase) |
0.7635 | Intermediate Similarity | NPD9494 | Approved |
0.7625 | Intermediate Similarity | NPD1653 | Approved |
0.7602 | Intermediate Similarity | NPD5953 | Discontinued |
0.76 | Intermediate Similarity | NPD3268 | Approved |
0.7595 | Intermediate Similarity | NPD7390 | Discontinued |
0.7588 | Intermediate Similarity | NPD7286 | Phase 2 |
0.7586 | Intermediate Similarity | NPD422 | Phase 1 |
0.7584 | Intermediate Similarity | NPD6832 | Phase 2 |
0.7584 | Intermediate Similarity | NPD4908 | Phase 1 |
0.758 | Intermediate Similarity | NPD2309 | Approved |
0.7568 | Intermediate Similarity | NPD2798 | Approved |
0.7566 | Intermediate Similarity | NPD1899 | Clinical (unspecified phase) |
0.7548 | Intermediate Similarity | NPD2346 | Discontinued |
0.7546 | Intermediate Similarity | NPD37 | Approved |
0.7534 | Intermediate Similarity | NPD9717 | Approved |
0.7532 | Intermediate Similarity | NPD7033 | Discontinued |
0.753 | Intermediate Similarity | NPD6234 | Discontinued |
0.7529 | Intermediate Similarity | NPD3751 | Discontinued |
0.7517 | Intermediate Similarity | NPD3018 | Phase 2 |
0.7516 | Intermediate Similarity | NPD6398 | Clinical (unspecified phase) |
0.7515 | Intermediate Similarity | NPD4965 | Approved |
0.7515 | Intermediate Similarity | NPD4967 | Phase 2 |
0.7515 | Intermediate Similarity | NPD4966 | Approved |
0.75 | Intermediate Similarity | NPD3787 | Discontinued |
0.75 | Intermediate Similarity | NPD2797 | Approved |
0.7483 | Intermediate Similarity | NPD4907 | Clinical (unspecified phase) |
0.7483 | Intermediate Similarity | NPD5536 | Phase 2 |
0.7468 | Intermediate Similarity | NPD6190 | Approved |
0.7466 | Intermediate Similarity | NPD1610 | Phase 2 |
0.7466 | Intermediate Similarity | NPD1547 | Clinical (unspecified phase) |
0.7458 | Intermediate Similarity | NPD8397 | Clinical (unspecified phase) |
0.7456 | Intermediate Similarity | NPD5242 | Approved |
0.7452 | Intermediate Similarity | NPD2654 | Approved |
0.7432 | Intermediate Similarity | NPD3225 | Approved |
0.7419 | Intermediate Similarity | NPD4308 | Phase 3 |
0.7415 | Intermediate Similarity | NPD1608 | Approved |
0.7389 | Intermediate Similarity | NPD4363 | Phase 3 |
0.7389 | Intermediate Similarity | NPD4360 | Phase 2 |
0.7378 | Intermediate Similarity | NPD6386 | Approved |
0.7378 | Intermediate Similarity | NPD6385 | Approved |
0.7375 | Intermediate Similarity | NPD4357 | Discontinued |
0.7368 | Intermediate Similarity | NPD411 | Approved |
0.7365 | Intermediate Similarity | NPD2983 | Phase 2 |
0.7365 | Intermediate Similarity | NPD2982 | Phase 2 |
0.7356 | Intermediate Similarity | NPD7685 | Pre-registration |
0.7349 | Intermediate Similarity | NPD5353 | Approved |
0.7333 | Intermediate Similarity | NPD6844 | Discontinued |
0.7329 | Intermediate Similarity | NPD7004 | Clinical (unspecified phase) |
0.731 | Intermediate Similarity | NPD2403 | Approved |
0.7308 | Intermediate Similarity | NPD8090 | Clinical (unspecified phase) |
0.7303 | Intermediate Similarity | NPD4625 | Phase 3 |
0.7297 | Intermediate Similarity | NPD9269 | Phase 2 |
0.7297 | Intermediate Similarity | NPD2981 | Phase 2 |
0.7294 | Intermediate Similarity | NPD5710 | Approved |
0.7294 | Intermediate Similarity | NPD5711 | Approved |
0.7288 | Intermediate Similarity | NPD8055 | Clinical (unspecified phase) |
0.7278 | Intermediate Similarity | NPD7879 | Clinical (unspecified phase) |
0.7267 | Intermediate Similarity | NPD3267 | Approved |
0.7267 | Intermediate Similarity | NPD3266 | Approved |
0.726 | Intermediate Similarity | NPD9268 | Approved |
0.7255 | Intermediate Similarity | NPD6798 | Discontinued |
0.7253 | Intermediate Similarity | NPD4362 | Clinical (unspecified phase) |
0.7253 | Intermediate Similarity | NPD4361 | Phase 2 |
0.7248 | Intermediate Similarity | NPD4749 | Approved |
0.7246 | Intermediate Similarity | NPD4288 | Approved |
0.7233 | Intermediate Similarity | NPD1652 | Phase 2 |
0.723 | Intermediate Similarity | NPD1201 | Approved |
0.7225 | Intermediate Similarity | NPD7228 | Approved |
0.7211 | Intermediate Similarity | NPD17 | Approved |
0.7209 | Intermediate Similarity | NPD7784 | Clinical (unspecified phase) |
0.7208 | Intermediate Similarity | NPD6233 | Phase 2 |
0.7193 | Intermediate Similarity | NPD7229 | Phase 3 |
0.7192 | Intermediate Similarity | NPD9545 | Approved |
0.7181 | Intermediate Similarity | NPD3972 | Approved |
0.7175 | Intermediate Similarity | NPD8313 | Approved |
0.7175 | Intermediate Similarity | NPD8312 | Approved |
0.7172 | Intermediate Similarity | NPD9493 | Approved |
0.7171 | Intermediate Similarity | NPD2861 | Phase 2 |
0.7169 | Intermediate Similarity | NPD7615 | Clinical (unspecified phase) |
0.7161 | Intermediate Similarity | NPD4307 | Phase 2 |
0.716 | Intermediate Similarity | NPD6971 | Discontinued |
0.7159 | Intermediate Similarity | NPD7039 | Approved |
0.7159 | Intermediate Similarity | NPD7038 | Approved |
0.7152 | Intermediate Similarity | NPD7458 | Discontinued |
0.7152 | Intermediate Similarity | NPD1470 | Approved |
0.7151 | Intermediate Similarity | NPD8434 | Phase 2 |
0.7143 | Intermediate Similarity | NPD7584 | Approved |
0.7143 | Intermediate Similarity | NPD1296 | Phase 2 |
0.7119 | Intermediate Similarity | NPD7549 | Discontinued |
0.7117 | Intermediate Similarity | NPD7422 | Clinical (unspecified phase) |
0.7115 | Intermediate Similarity | NPD5124 | Phase 1 |
0.7115 | Intermediate Similarity | NPD6355 | Discontinued |
0.7115 | Intermediate Similarity | NPD5123 | Clinical (unspecified phase) |
0.7105 | Intermediate Similarity | NPD1019 | Discontinued |
0.7101 | Intermediate Similarity | NPD5019 | Clinical (unspecified phase) |
0.7083 | Intermediate Similarity | NPD1241 | Discontinued |
0.7083 | Intermediate Similarity | NPD5283 | Phase 1 |
0.7081 | Intermediate Similarity | NPD4109 | Clinical (unspecified phase) |
0.7081 | Intermediate Similarity | NPD4110 | Phase 3 |
0.7073 | Intermediate Similarity | NPD1940 | Clinical (unspecified phase) |
Bioactivity similarity was calculated based on bioactivity descriptors of compounds. The bioactivity descriptors were calculated by a recently developed AI algorithm Chemical Checker (CC) [Nature Biotechnology, 38:1087–1096, 2020; Nature Communications, 12:3932, 2021], which evaluated bioactivity similarities at five levels:
☉ A: chemistry similarity;
☉ B: biological targets similarity;
☉ C: networks similarity;
☉ D: cell-based bioactivity similarity;
☉ E: similarity based on clinical data.
Those 5 categories of CC bioactivity descriptors were calculated and then subjected to manifold projection using UMAP algorithm, to project all NPs on a 2-Dimensional space. The current NP was highlighted with a small circle in the 2-D map. Below figures: left-to-right, A-to-E.