NPASS Compound

Structure

Physi-Chem Properties

Molecular Weight:	206.06
Volume:	203.678
LogP:	1.38
LogD:	1.458
LogS:	-2.094
# Rotatable Bonds:	2
TPSA:	48.67
# H-Bond Aceptor:	4
# H-Bond Donor:	0
# Rings:	2
# Heavy Atoms:	4

MedChem Properties

QED Drug-Likeness Score:	0.703
Synthetic Accessibility Score:	1.858
Fsp3:	0.182
Lipinski Rule-of-5:	Accepted
Pfizer Rule:	Accepted
GSK Rule:	Accepted
BMS Rule:	0
Golden Triangle Rule:	Accepted
Chelating Alert:	0
PAINS Alert:	0

ADMET Properties (ADMETlab2.0)

ADMET: Absorption

Caco-2 Permeability:	-4.656
MDCK Permeability:	3.1250488973455504e-05
Pgp-inhibitor:	0.019
Pgp-substrate:	0.128
Human Intestinal Absorption (HIA):	0.005
20% Bioavailability (F20%):	0.008
30% Bioavailability (F30%):	0.988

ADMET: Distribution

Blood-Brain-Barrier Penetration (BBB):	0.498
Plasma Protein Binding (PPB):	66.48306274414062%
Volume Distribution (VD):	0.882
Pgp-substrate:	25.659587860107422%

ADMET: Metabolism

CYP1A2-inhibitor:	0.967
CYP1A2-substrate:	0.968
CYP2C19-inhibitor:	0.319
CYP2C19-substrate:	0.624
CYP2C9-inhibitor:	0.034
CYP2C9-substrate:	0.855
CYP2D6-inhibitor:	0.178
CYP2D6-substrate:	0.906
CYP3A4-inhibitor:	0.085
CYP3A4-substrate:	0.475

ADMET: Excretion

Clearance (CL):	11.015
Half-life (T1/2):	0.814

ADMET: Toxicity

hERG Blockers:	0.203
Human Hepatotoxicity (H-HT):	0.368
Drug-inuced Liver Injury (DILI):	0.873
AMES Toxicity:	0.117
Rat Oral Acute Toxicity:	0.072
Maximum Recommended Daily Dose:	0.151
Skin Sensitization:	0.322
Carcinogencity:	0.496
Eye Corrosion:	0.222
Eye Irritation:	0.898
Respiratory Toxicity:	0.069

Download Data

Data Type	Select
General Info & Identifiers & Properties
Structure MOL file
Source Organisms
Biological Activities
Similar NPs/Drugs

Natural Product: NPC240722

Natural Product ID:	NPC240722
*Common Name:**	Scoparone
IUPAC Name:	6,7-dimethoxychromen-2-one
Synonyms:	6,7-Dimethoxycoumarin; 6,7-Dimethylcoumarine; Aesculetin Dimethyl Ether; Scoparone
Standard InCHIKey:	GUAFOGOEJLSQBT-UHFFFAOYSA-N
Standard InCHI:	InChI=1S/C11H10O4/c1-13-9-5-7-3-4-11(12)15-8(7)6-10(9)14-2/h3-6H,1-2H3
SMILES:	COc1cc2ccc(=O)oc2cc1OC
Synthetic Gene Cluster:	n.a.
ChEMBL Identifier:	CHEMBL325864
PubChem CID:	8417
Chemical Classification:**	CHEMONTID:0000000 [Organic compounds] [CHEMONTID:0000261] Phenylpropanoids and polyketides [CHEMONTID:0000145] Coumarins and derivatives

*Note: the InCHIKey will be temporarily assigned as the "Common Name" if no IUPAC name or alternative short name is available.
**Note: the Chemical Classification was calculated by NPClassifier Version 1.5. Reference: PMID:34662515.

Species Source

Organism ID	Organism Name	Taxonomy Level	Family	SuperKingdom	Isolation Part	Collection Location	Collection Time	Reference
NPO26589	Artemisia annua L.	Strain	Asteraceae	Eukaryota	n.a.	stem	n.a.	DOI[10.1007/s11418-006-0112-9]
NPO26589	Artemisia annua L.	Strain	Asteraceae	Eukaryota	n.a.	leaf	n.a.	DOI[10.1007/s11418-006-0112-9]
NPO26589	Artemisia annua L.	Strain	Asteraceae	Eukaryota	n.a.	flower	n.a.	DOI[10.1007/s11418-006-0112-9]
NPO26992	Sophora leachiana	Species	Fabaceae	Eukaryota	n.a.	root	n.a.	DOI[10.1016/0031-9422(90)85209-X]
NPO28276	Artemisia argyi	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	DOI[10.1016/j.jep.2005.01.054]
NPO7576.2	Brassica oleracea var. sabauda	Varieties	Brassicaceae	Eukaryota	n.a.	n.a.	n.a.	DOI[10.1016/j.jfca.2004.07.004]
NPO7576.2	Brassica oleracea var. sabauda	Varieties	Brassicaceae	Eukaryota	n.a.	n.a.	n.a.	DOI[10.1016/j.jfca.2005.08.001]
NPO7576.2	Brassica oleracea var. sabauda	Varieties	Brassicaceae	Eukaryota	n.a.	retail stores, supermarkets and market stalls in Forssa and in the Helsinki area	2003–2005	DOI[10.1016/j.jfca.2006.05.007]
NPO24758	Angelica dahurica	Species	Apiaceae	Eukaryota	n.a.	root	n.a.	DOI[10.5012/bkcs.2003.24.11.1699]
NPO26409	Plakortis simplex	Species	Plakinidae	Eukaryota	n.a.	Caribbean	n.a.	PMID[10021943]
NPO7576.2	Brassica oleracea var. sabauda	Varieties	Brassicaceae	Eukaryota	n.a.	n.a.	1996-Sep	PMID[10352947]
NPO21390	Zanthoxylum integrifoliolum	Species	Rutaceae	Eukaryota	fruit	Lanyu Island, Taitung County, Taiwan	n.a.	PMID[10395498]
NPO10763	Aralia dasyphylla	Species	Araliaceae	Eukaryota	root bark	n.a.	n.a.	PMID[10425135]
NPO19787	Citrus sinensis	Species	Rutaceae	Eukaryota	n.a.	fruit	n.a.	PMID[10606547]
NPO26409	Plakortis simplex	Species	Plakinidae	Eukaryota	n.a.	Taiwan	n.a.	PMID[11277748]
NPO12176	Streptomyces olivaceus	Species	Streptomycetaceae	Bacteria	n.a.	n.a.	n.a.	PMID[11376004]
NPO3894	Dendrobium nobile	Species	Orchidaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[11575955]
NPO8884	Cuscuta reflexa	Species	Convolvulaceae	Eukaryota	n.a.	whole plant	n.a.	PMID[11824569]
NPO18265	Citrus tamurana	Species	Rutaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[11999424]
NPO24758	Angelica dahurica	Species	Apiaceae	Eukaryota	n.a.	root	n.a.	PMID[12510838]
NPO15289	Scoparia dulcis	Species	Plantaginaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[12880314]
NPO15289	Scoparia dulcis	Species	Plantaginaceae	Eukaryota	n.a.	whole plant	n.a.	PMID[1294695]
NPO12176	Streptomyces olivaceus	Species	Streptomycetaceae	Bacteria	n.a.	n.a.	n.a.	PMID[1367428]
NPO25302	Viola philippica	Species	Violaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[14519932]
NPO6708	Cordia multispicata	Species	Cordiaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[14575428]
NPO21334	Artemisia dracunculus	Species	Asteraceae	Eukaryota	dried aerial organs	n.a.	n.a.	PMID[14738379]
NPO21334	Artemisia dracunculus	Species	Asteraceae	Eukaryota	roots and stolons	n.a.	n.a.	PMID[14738379]
NPO21334	Artemisia dracunculus	Species	Asteraceae	Eukaryota	leaves	n.a.	n.a.	PMID[14738379]
NPO21334	Artemisia dracunculus	Species	Asteraceae	Eukaryota	dried aerial organs	n.a.	n.a.	PMID[14738379]
NPO21334	Artemisia dracunculus	Species	Asteraceae	Eukaryota	underground organs	n.a.	n.a.	PMID[14738379]
NPO10474	Latrunculia brevis	Species	Latrunculiidae	Eukaryota	n.a.	n.a.	n.a.	PMID[15043433]
NPO15289	Scoparia dulcis	Species	Plantaginaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[15104516]
NPO851	Eupatorium lindleyanum	Species	Asteraceae	Eukaryota	Whole plant	Songyang County, Zhejiang Province, China	n.a.	PMID[15387644]
NPO21341	Morus macroura	Species	Moraceae	Eukaryota	n.a.	stem	n.a.	PMID[15467233]
NPO24758	Angelica dahurica	Species	Apiaceae	Eukaryota	n.a.	root	n.a.	PMID[15646793]
NPO7576.2	Brassica oleracea var. sabauda	Varieties	Brassicaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[15877880]
NPO26409	Plakortis simplex	Species	Plakinidae	Eukaryota	n.a.	n.a.	n.a.	PMID[15921424]
NPO9518	Gardenia jasminoides	Species	Rubiaceae	Eukaryota	Fruits	n.a.	n.a.	PMID[16309325]
NPO15289	Scoparia dulcis	Species	Plantaginaceae	Eukaryota	leaves and twigs	Taiwan	n.a.	PMID[1659612]
NPO9518	Gardenia jasminoides	Species	Rubiaceae	Eukaryota	n.a.	Seoul, Korea	2000-Jun	PMID[16643034]
NPO29221	Sarcandra glabra	Species	Chloranthaceae	Eukaryota	Whole plant	n.a.	n.a.	PMID[16643038]
NPO13854	Prunus serotina	Species	Rosaceae	Eukaryota	n.a.	kernel	n.a.	PMID[16652960]
NPO7576.2	Brassica oleracea var. sabauda	Varieties	Brassicaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[17011103]
NPO21387	Forsythia suspensa	Species	Oleaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[17156960]
NPO3894	Dendrobium nobile	Species	Orchidaceae	Eukaryota	stems	Yunnan Province, China	2004	PMID[17253844]
NPO14761	Serratula wolffii	Species	Asteraceae	Eukaryota	roots	n.a.	n.a.	PMID[17417908]
NPO21390	Zanthoxylum integrifoliolum	Species	Rutaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[17822293]
NPO25094	Artemisia princeps	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	PMID[17996677]
NPO3894	Dendrobium nobile	Species	Orchidaceae	Eukaryota	Stems	purchased from Kyoungdong Oriental Herbal Market, Seoul, Korea	2006-APR	PMID[18052323]
NPO18723	Zanthoxylum avicennae	Species	Rutaceae	Eukaryota	stem wood	Pakuashan, Changhua County, Taiwan	2006-Jun	PMID[18211005]
NPO9650	Zanthoxylum nitidum	Species	Rutaceae	Eukaryota	stem bark	n.a.	n.a.	PMID[18303853]
NPO9650	Zanthoxylum nitidum	Species	Rutaceae	Eukaryota	Stems; Barks	n.a.	n.a.	PMID[18303853]
NPO2291	Saussurea pulchella	Species	Asteraceae	Eukaryota	aerial parts	n.a.	n.a.	PMID[18314958]
NPO7576.2	Brassica oleracea var. sabauda	Varieties	Brassicaceae	Eukaryota	n.a.	Northeastern Regional Plant Introduction Station at Geneva	1966, 1967, and 1968 crop seasons	PMID[18460139]
NPO7576.2	Brassica oleracea var. sabauda	Varieties	Brassicaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[18460139]
NPO22421	Microtropis japonica	Species	Celastraceae	Eukaryota	stem	n.a.	n.a.	PMID[18471021]
NPO22421	Microtropis japonica	Species	Celastraceae	Eukaryota	n.a.	stem	n.a.	PMID[18471021]
NPO9518	Gardenia jasminoides	Species	Rubiaceae	Eukaryota	fruit	n.a.	n.a.	PMID[18505286]
NPO5045	Aegle marmelos	Species	Rutaceae	Eukaryota	leaves	n.a.	n.a.	PMID[18760601]
NPO26203	Dysidea villosa	Species	Dysideidae	Eukaryota	n.a.	Hainan, China	n.a.	PMID[19091557]
NPO2188	Dendrobium candidum	Species	Orchidaceae	Eukaryota	n.a.	stem	n.a.	PMID[19182417]
NPO33077	garcinina multiflora	Species	n.a.	n.a.	fruits	n.a.	n.a.	PMID[19203247]
NPO22421	Microtropis japonica	Species	Celastraceae	Eukaryota	Stems	n.a.	n.a.	PMID[19534471]
NPO9518	Gardenia jasminoides	Species	Rubiaceae	Eukaryota	fruit	n.a.	n.a.	PMID[19650637]
NPO29221	Sarcandra glabra	Species	Chloranthaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[20038159]
NPO10464	Epipedobates anthonyi	Species	Dendrobatidae	Eukaryota	n.a.	n.a.	n.a.	PMID[20337496]
NPO15090	Zanthoxylum leprieurii	Species	Rutaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[20413315]
NPO11100	Artemisia capillaris	Species	Asteraceae	Eukaryota	n.a.	whole plant	n.a.	PMID[21428416]
NPO24758	Angelica dahurica	Species	Apiaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[21625478]
NPO24758	Angelica dahurica	Species	Apiaceae	Eukaryota	n.a.	root	n.a.	PMID[21657081]
NPO5045	Aegle marmelos	Species	Rutaceae	Eukaryota	n.a.	bark	n.a.	PMID[21875114]
NPO11100	Artemisia capillaris	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	PMID[22870812]
NPO9518	Gardenia jasminoides	Species	Rubiaceae	Eukaryota	fruits	n.a.	n.a.	PMID[23305920]
NPO5045	Aegle marmelos	Species	Rutaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[23434131]
NPO11100	Artemisia capillaris	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	PMID[23435948]
NPO12721	Liriodendron tulipifera	Species	Magnoliaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[23501116]
NPO26409	Plakortis simplex	Species	Plakinidae	Eukaryota	n.a.	n.a.	n.a.	PMID[23806071]
NPO11237	Bupleurum salicifolium	Species	Apiaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[24242108]
NPO15289	Scoparia dulcis	Species	Plantaginaceae	Eukaryota	aerial parts	Nanning, Guangxi Zhuang Autonomous Region, Peoples Republic of China	2012-OCT	PMID[24955889]
NPO26409	Plakortis simplex	Species	Plakinidae	Eukaryota	n.a.	China	n.a.	PMID[25115700]
NPO23332	Dendrobium fimbriatum	Species	Orchidaceae	Eukaryota	stems	n.a.	n.a.	PMID[25316316]
NPO29221	Sarcandra glabra	Species	Chloranthaceae	Eukaryota	aerial part	n.a.	n.a.	PMID[25442304]
NPO30303	Pueraria lobata	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[25679337]
NPO11100	Artemisia capillaris	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	PMID[25737008]
NPO5045	Aegle marmelos	Species	Rutaceae	Eukaryota	n.a.	fruit	n.a.	PMID[26247834]
NPO21387	Forsythia suspensa	Species	Oleaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[26422318]
NPO26298	Zanthoxylum simulans	Species	Rutaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[26666037]
NPO3894	Dendrobium nobile	Species	Orchidaceae	Eukaryota	Stems	n.a.	n.a.	PMID[27310249]
NPO24758	Angelica dahurica	Species	Apiaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[27444348]
NPO25406	Celastrus monospermus	Species	Celastraceae	Eukaryota	n.a.	n.a.	n.a.	PMID[28006915]
NPO21387	Forsythia suspensa	Species	Oleaceae	Eukaryota	Fruits	n.a.	n.a.	PMID[28218000]
NPO7576.2	Brassica oleracea var. sabauda	Varieties	Brassicaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[2831703]
NPO5045	Aegle marmelos	Species	Rutaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[30579794]
NPO28276	Artemisia argyi	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	PMID[31181920]
NPO865	Dendrobium loddigesii	Species	Orchidaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[31291099]
NPO28276	Artemisia argyi	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	PMID[31418264]
NPO24758	Angelica dahurica	Species	Apiaceae	Eukaryota	Roots	n.a.	n.a.	PMID[31464439]
NPO21334	Artemisia dracunculus	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	PMID[31815461]
NPO12422	Pinus massoniana	Species	Pinaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[32100544]
NPO26277	Euphorbia hirta	Species	Euphorbiaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[32141299]
NPO9518	Gardenia jasminoides	Species	Rubiaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[32141747]
NPO8500	Acanthopanax gracilistylus	Species	Araliaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[32319765]
NPO40011	Allamanda schottii	Species	Apocynaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[3379414]
NPO26589	Artemisia annua L.	Strain	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	PMID[6387056]
NPO26298	Zanthoxylum simulans	Species	Rutaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[7798955]
NPO11237	Bupleurum salicifolium	Species	Apiaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[7964800]
NPO23441	Schisandra sphaerandra	Species	Schisandraceae	Eukaryota	n.a.	stem	n.a.	PMID[8778243]
NPO21610	Laurencia rigida	Species	Rhodomelaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[9358636]
NPO12176	Streptomyces olivaceus	Species	Streptomycetaceae	Bacteria	n.a.	n.a.	n.a.	Database[Article]
NPO13854	Prunus serotina	Species	Rosaceae	Eukaryota	n.a.	n.a.	n.a.	Database[Article]
NPO7576.2	Brassica oleracea var. sabauda	Varieties	Brassicaceae	Eukaryota	Roots	n.a.		Database[FooDB]
NPO19787	Citrus sinensis	Species	Rutaceae	Eukaryota	Fruit	n.a.	n.a.	Database[FooDB]
NPO19787	Citrus sinensis	Species	Rutaceae	Eukaryota	Fruit Juice	n.a.	n.a.	Database[FooDB]
NPO21334	Artemisia dracunculus	Species	Asteraceae	Eukaryota	Leaf	n.a.	n.a.	Database[FooDB]
NPO19787	Citrus sinensis	Species	Rutaceae	Eukaryota	Pericarp	n.a.	n.a.	Database[FooDB]
NPO21334	Artemisia dracunculus	Species	Asteraceae	Eukaryota	Plant	n.a.	n.a.	Database[FooDB]
NPO19787	Citrus sinensis	Species	Rutaceae	Eukaryota	Root Bark	n.a.	n.a.	Database[FooDB]
NPO21334	Artemisia dracunculus	Species	Asteraceae	Eukaryota	Seed	n.a.	n.a.	Database[FooDB]
NPO21334	Artemisia dracunculus	Species	Asteraceae	Eukaryota	Shoot	n.a.	n.a.	Database[FooDB]
NPO21334	Artemisia dracunculus	Species	Asteraceae	Eukaryota		n.a.	n.a.	Database[FooDB]
NPO19787	Citrus sinensis	Species	Rutaceae	Eukaryota		n.a.	n.a.	Database[FooDB]
NPO19787	Citrus sinensis	Species	Rutaceae	Eukaryota	Bark	n.a.	n.a.	Database[FooDB]
NPO19787	Citrus sinensis	Species	Rutaceae	Eukaryota	n.a.	n.a.		Database[FooDB]
NPO7576.2	Brassica oleracea var. sabauda	Varieties	Brassicaceae	Eukaryota	n.a.	n.a.		Database[FooDB]
NPO15289	Scoparia dulcis	Species	Plantaginaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO7576.2	Brassica oleracea var. sabauda	Varieties	Brassicaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO26298	Zanthoxylum simulans	Species	Rutaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO25122	Conium maculatum	Species	Apiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO20900	Dendrobium chrysotoxum	Species	Orchidaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO18265	Citrus tamurana	Species	Rutaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO15730.1	Citrus medica var. etrog	Varieties	Rutaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO10506	Artemisia apiacea	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO12422	Pinus massoniana	Species	Pinaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO851	Eupatorium lindleyanum	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO11100	Artemisia capillaris	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO12100	Citrus sulcata	Species	Rutaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO4271	Dendrobium thyrsiflorum	Species	Orchidaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO3894	Dendrobium nobile	Species	Orchidaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO30303	Pueraria lobata	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO6708	Cordia multispicata	Species	Cordiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO28276	Artemisia argyi	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO9650	Zanthoxylum nitidum	Species	Rutaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO9063	Dendrobium capillipes	Species	Orchidaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO7991	Lactarius vellereus	Species	Russulaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO2291	Saussurea pulchella	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO16308	Citrus wilsonii	Species	Rutaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO14650	Lobelia chinensis	Species	Campanulaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO24737	Gentiana kuroo	Species	Gentianaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO10750	Bupleurum fruticescens	Species	Apiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO638	Aralia fargesii	Species	Araliaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO15730	Citrus medica	Species	Rutaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO14773	Uncaria perrottetii	Species	Rubiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO18655	Clerodendranthus spicatus	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO24758	Angelica dahurica	Species	Apiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO25094	Artemisia princeps	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO5045	Aegle marmelos	Species	Rutaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO2775	Cyathula officinalis	Species	Amaranthaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO20787	Achyranthes aspera	Species	Amaranthaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO4307	Canarium album	Species	Burseraceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO12721	Liriodendron tulipifera	Species	Magnoliaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO19319	Cedrelopsis grevei	Species	Rutaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO18681	Artemisia scoparia	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO15730.2	Citrus medica var. sarcodactylis	Varieties	Rutaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO22524	Ranunculus sceleratus	Species	Ranunculaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO29285	Dendrobium densiflorum	Species	Orchidaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO19672	Hosta sieboldiana	Species	Asparagaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO21387	Forsythia suspensa	Species	Oleaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO24478	Morinda coreia	Species	Rubiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO8884	Cuscuta reflexa	Species	Convolvulaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO26589	Artemisia annua L.	Strain	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO21341	Morus macroura	Species	Moraceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO7142	Corydalis suaveolens	Species	Papaveraceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO14951	Zanthoxylum acanthopodium	Species	Rutaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO19787	Citrus sinensis	Species	Rutaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO4033	Corydalis gigantea	Species	Papaveraceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO18723	Zanthoxylum avicennae	Species	Rutaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO30253	Duranta repens	Species	Verbenaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO8698	Zanthoxylum schinifolium	Species	Rutaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO865	Dendrobium loddigesii	Species	Orchidaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO20419	Buxus wallichiana	Species	Buxaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO3011	Rubia wallichiana	Species	Rubiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO26992	Sophora leachiana	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO13854	Prunus serotina	Species	Rosaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO5740	Phellodendron japonicum	Species	Rutaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO29221	Sarcandra glabra	Species	Chloranthaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO5895	Hibiscus taiwanensis	Species	Malvaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO9518	Gardenia jasminoides	Species	Rubiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO26277	Euphorbia hirta	Species	Euphorbiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO21334	Artemisia dracunculus	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO25494.1	Dendrobium aurantiacum var. denneanum	Varieties	Orchidaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO14974.1	0stoc commune var. flagelliforme	Varieties	0stocaceae	Bacteria	n.a.	n.a.	n.a.	Database[MetaboLights]
NPO7576.2	Brassica oleracea var. sabauda	Varieties	Brassicaceae	Eukaryota	n.a.	n.a.		Database[Phenol-Explorer]
NPO12874	Sedum cepaea	Species	Crassulaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO24737	Gentiana kuroo	Species	Gentianaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO28276	Artemisia argyi	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO638	Aralia fargesii	Species	Araliaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO18681	Artemisia scoparia	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO14974.1	0stoc commune var. flagelliforme	Varieties	0stocaceae	Bacteria	n.a.	n.a.	n.a.	Database[TCMID]
NPO7991	Lactarius vellereus	Species	Russulaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO4271	Dendrobium thyrsiflorum	Species	Orchidaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO25094	Artemisia princeps	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO21341	Morus macroura	Species	Moraceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO16308	Citrus wilsonii	Species	Rutaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO851	Eupatorium lindleyanum	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO11186	Duranta erecta	Species	Verbenaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO865	Dendrobium loddigesii	Species	Orchidaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO12721	Liriodendron tulipifera	Species	Magnoliaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO11889	Dendrobium chrysanthum	Species	Orchidaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO14773	Uncaria perrottetii	Species	Rubiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO3894	Dendrobium nobile	Species	Orchidaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO9063	Dendrobium capillipes	Species	Orchidaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO26992	Sophora leachiana	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO26298	Zanthoxylum simulans	Species	Rutaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO6669	Dysosma delavayi	Species	Berberidaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO8698	Zanthoxylum schinifolium	Species	Rutaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO21413	Armillaria tabescens	Species	Physalacriaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO15730.1	Citrus medica var. etrog	Varieties	Rutaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO10506	Artemisia apiacea	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO2291	Saussurea pulchella	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO2775	Cyathula officinalis	Species	Amaranthaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO7576.2	Brassica oleracea var. sabauda	Varieties	Brassicaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO14650	Lobelia chinensis	Species	Campanulaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO7142	Corydalis suaveolens	Species	Papaveraceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO5933	Drimia fugax	Species	Hyacinthaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO20900	Dendrobium chrysotoxum	Species	Orchidaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO4033	Corydalis gigantea	Species	Papaveraceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO25122	Conium maculatum	Species	Apiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO19319	Cedrelopsis grevei	Species	Rutaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO9721	Radix moghaniae philippinensis	Species	Lymnaeidae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO18677	Anagallis arvensis	Species	Primulaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO12422	Pinus massoniana	Species	Pinaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO18039	Herba dendrobii	n.a.	n.a.	n.a.	n.a.	n.a.	n.a.	Database[TCMID]
NPO21390	Zanthoxylum integrifoliolum	Species	Rutaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO15730	Citrus medica	Species	Rutaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO19787	Citrus sinensis	Species	Rutaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO8884	Cuscuta reflexa	Species	Convolvulaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO14951	Zanthoxylum acanthopodium	Species	Rutaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO29285	Dendrobium densiflorum	Species	Orchidaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO18265	Citrus tamurana	Species	Rutaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO21334	Artemisia dracunculus	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO24758	Angelica dahurica	Species	Apiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO9650	Zanthoxylum nitidum	Species	Rutaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO26277	Euphorbia hirta	Species	Euphorbiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO18655	Clerodendranthus spicatus	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO9518	Gardenia jasminoides	Species	Rubiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO12100	Citrus sulcata	Species	Rutaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO23441	Schisandra sphaerandra	Species	Schisandraceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO19672	Hosta sieboldiana	Species	Asparagaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO11400	Aster ptarmicoides	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO24478	Morinda coreia	Species	Rubiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO13854	Prunus serotina	Species	Rosaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO5740	Phellodendron japonicum	Species	Rutaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO22524	Ranunculus sceleratus	Species	Ranunculaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO20419	Buxus wallichiana	Species	Buxaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO25302	Viola philippica	Species	Violaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO25494.1	Dendrobium aurantiacum var. denneanum	Varieties	Orchidaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO3011	Rubia wallichiana	Species	Rubiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO5895	Hibiscus taiwanensis	Species	Malvaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO26589	Artemisia annua L.	Strain	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO18723	Zanthoxylum avicennae	Species	Rutaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO4307	Canarium album	Species	Burseraceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO15730.2	Citrus medica var. sarcodactylis	Varieties	Rutaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO9394	Herba artemisiae scopariae	n.a.	n.a.	n.a.	n.a.	n.a.	n.a.	Database[TCMID]
NPO11100	Artemisia capillaris	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO20787	Achyranthes aspera	Species	Amaranthaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO13313	Talipariti tiliaceum	Species	Malvaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO8707.1	Pueraria montana var. lobata	Varieties	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO29221	Sarcandra glabra	Species	Chloranthaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO21387	Forsythia suspensa	Species	Oleaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO10750	Bupleurum fruticescens	Species	Apiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO8500	Acanthopanax gracilistylus	Species	Araliaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO15289	Scoparia dulcis	Species	Plantaginaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO6708	Cordia multispicata	Species	Cordiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO5045	Aegle marmelos	Species	Rutaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO7576.2	Brassica oleracea var. sabauda	Varieties	Brassicaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO16308	Citrus wilsonii	Species	Rutaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO8698	Zanthoxylum schinifolium	Species	Rutaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO18723	Zanthoxylum avicennae	Species	Rutaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO4033	Corydalis gigantea	Species	Papaveraceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO851	Eupatorium lindleyanum	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO865	Dendrobium loddigesii	Species	Orchidaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO638	Aralia fargesii	Species	Araliaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO13854	Prunus serotina	Species	Rosaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO15289	Scoparia dulcis	Species	Plantaginaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO26298	Zanthoxylum simulans	Species	Rutaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO20419	Buxus wallichiana	Species	Buxaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO25122	Conium maculatum	Species	Apiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO12422	Pinus massoniana	Species	Pinaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO2775	Cyathula officinalis	Species	Amaranthaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO15730.2	Citrus medica var. sarcodactylis	Varieties	Rutaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO26589	Artemisia annua L.	Strain	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO10750	Bupleurum fruticescens	Species	Apiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO9650	Zanthoxylum nitidum	Species	Rutaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO24758	Angelica dahurica	Species	Apiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO10506	Artemisia apiacea	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO5045	Aegle marmelos	Species	Rutaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO13704	Endarachne binghamiae	Species	Scytosiphonaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO4307	Canarium album	Species	Burseraceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO4271	Dendrobium thyrsiflorum	Species	Orchidaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO28276	Artemisia argyi	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO15730	Citrus medica	Species	Rutaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO14650	Lobelia chinensis	Species	Campanulaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO3894	Dendrobium nobile	Species	Orchidaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO19672	Hosta sieboldiana	Species	Asparagaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO18681	Artemisia scoparia	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO30253	Duranta repens	Species	Verbenaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO24737	Gentiana kuroo	Species	Gentianaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO30739	Forsythia suspense	Species	Oleaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO2291	Saussurea pulchella	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO9518	Gardenia jasminoides	Species	Rubiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO19787	Citrus sinensis	Species	Rutaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO12721	Liriodendron tulipifera	Species	Magnoliaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO31579	Artemisia capillaries	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO30303	Pueraria lobata	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO11100	Artemisia capillaris	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO26277	Euphorbia hirta	Species	Euphorbiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TM-MC]
NPO2775	Cyathula officinalis	Species	Amaranthaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TM-MC]
NPO8837	Viola mandshurica	Species	Violaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TM-MC]
NPO25094	Artemisia princeps	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[TM-MC]
NPO10492	Artemisia montana	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[TM-MC]
NPO3894	Dendrobium nobile	Species	Orchidaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TM-MC]
NPO9518	Gardenia jasminoides	Species	Rubiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TM-MC]
NPO8698	Zanthoxylum schinifolium	Species	Rutaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TM-MC]
NPO14650	Lobelia chinensis	Species	Campanulaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TM-MC]
NPO851	Eupatorium lindleyanum	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[TM-MC]
NPO11889	Dendrobium chrysanthum	Species	Orchidaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TM-MC]
NPO24758	Angelica dahurica	Species	Apiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TM-MC]
NPO10506	Artemisia apiacea	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[TM-MC]
NPO16308	Citrus wilsonii	Species	Rutaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TM-MC]
NPO9650	Zanthoxylum nitidum	Species	Rutaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TM-MC]
NPO2188	Dendrobium candidum	Species	Orchidaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TM-MC]
NPO12422	Pinus massoniana	Species	Pinaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TM-MC]
NPO21387	Forsythia suspensa	Species	Oleaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TM-MC]
NPO15730	Citrus medica	Species	Rutaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TM-MC]
NPO20900	Dendrobium chrysotoxum	Species	Orchidaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TM-MC]
NPO19787	Citrus sinensis	Species	Rutaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TM-MC]
NPO4307	Canarium album	Species	Burseraceae	Eukaryota	n.a.	n.a.	n.a.	Database[TM-MC]
NPO11100	Artemisia capillaris	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[TM-MC]
NPO865	Dendrobium loddigesii	Species	Orchidaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TM-MC]
NPO29221	Sarcandra glabra	Species	Chloranthaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TM-MC]
NPO23332	Dendrobium fimbriatum	Species	Orchidaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TM-MC]
NPO25302	Viola philippica	Species	Violaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TM-MC]
NPO8707.1	Pueraria montana var. lobata	Varieties	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TM-MC]
NPO26589	Artemisia annua L.	Strain	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[TM-MC]
NPO28276	Artemisia argyi	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[TM-MC]
NPO8500	Acanthopanax gracilistylus	Species	Araliaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TM-MC]
NPO23441	Schisandra sphaerandra	Species	Schisandraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO21030	Monascus kaoliang	Species	Aspergillaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO15730	Citrus medica	Species	Rutaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO11237	Bupleurum salicifolium	Species	Apiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO14974.1	0stoc commune var. flagelliforme	Varieties	0stocaceae	Bacteria	n.a.	n.a.	n.a.	Database[UNPD]
NPO18655	Clerodendranthus spicatus	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO3011	Rubia wallichiana	Species	Rubiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO25302	Viola philippica	Species	Violaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO18677	Anagallis arvensis	Species	Primulaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO7991	Lactarius vellereus	Species	Russulaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO15090	Zanthoxylum leprieurii	Species	Rutaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO4307	Canarium album	Species	Burseraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO24918	Jacobaea cannabifolia	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO10750	Bupleurum fruticescens	Species	Apiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO21390	Zanthoxylum integrifoliolum	Species	Rutaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO11482	Monodora brevipes	Species	Annonaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO3110	Selaginella labordei	Species	Selaginellaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO12721	Liriodendron tulipifera	Species	Magnoliaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO1460	Rubus phoenicolasius	Species	Rosaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO22421	Microtropis japonica	Species	Celastraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO16308	Citrus wilsonii	Species	Rutaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO226	Bombina variegata	Species	Bombinatoridae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO7327	Aeromonas hydrophila	Species	Aeromonadaceae	Bacteria	n.a.	n.a.	n.a.	Database[UNPD]
NPO3963	Hortonia floribunda	Species	Monimiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO4271	Dendrobium thyrsiflorum	Species	Orchidaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO19319	Cedrelopsis grevei	Species	Rutaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO21629	Pometia eximia	Species	Sapindaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO11400	Aster ptarmicoides	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO12437	Kleinia fulgens	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO20118	Hormothamnion enteromorphoides	n.a.	n.a.	n.a.	n.a.	n.a.	n.a.	Database[UNPD]
NPO3277	Salix alba	Species	Salicaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO26992	Sophora leachiana	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO26589	Artemisia annua L.	Strain	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO1267	Acronychia laurifolia	Species	Rutaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO26203	Dysidea villosa	Species	Dysideidae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO15248	Eriostemon tomentellus	Species	Rutaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO25259	Schrebera swietenoides	Species	Oleaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO9496	Gomphostemma crinitum	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO16792	0cardia pseudobrasiliensis	Species	0cardiaceae	Bacteria	n.a.	n.a.	n.a.	Database[UNPD]
NPO22524	Ranunculus sceleratus	Species	Ranunculaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO22734	Neopringlea integrifolia	Species	Salicaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO8226	Esenbeckia flava	Species	Rutaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO1117	Hypholoma capnoides	Species	Strophariaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO22915	Stereocaulon azoreum	Species	Stereocaulaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO9518	Gardenia jasminoides	Species	Rubiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO21835	Buxus rugulosa	Species	Buxaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO6708	Cordia multispicata	Species	Cordiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO9324	0techis scutatus	Species	Elapidae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO3614	Echinopepon bigelovii	Species	Cucurbitaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO7142	Corydalis suaveolens	Species	Papaveraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO2582	Plagiomnium undulatum	Species	Mniaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO865	Dendrobium loddigesii	Species	Orchidaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO24547	Xanthoria parietina	Species	Teloschistaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO991	Dimelaena oreina	Species	Caliciaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO18681	Artemisia scoparia	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO19672	Hosta sieboldiana	Species	Asparagaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO28636	Vernonia lilacina	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO8698	Zanthoxylum schinifolium	Species	Rutaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO10354	Urbanodendron verrucosum	Species	Lauraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO17102	Ocypus olens	Species	Staphylinidae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO26298	Zanthoxylum simulans	Species	Rutaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO1911	Ranunculus laetus	Species	Ranunculaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO29221	Sarcandra glabra	Species	Chloranthaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO7653	Mosla japonica	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO2629	Cystoseira caespitosa	Species	Sargassaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO3954	Lanaria lanata	Species	Lanariaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO12100	Citrus sulcata	Species	Rutaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO14951	Zanthoxylum acanthopodium	Species	Rutaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO954	Erythroxylum passerinum	Species	Erythroxylaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO28276	Artemisia argyi	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO24248.1	Lactarius deliciosus var. deterrimus	Varieties	Russulaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO10492	Artemisia montana	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO13658	Elsholtzia cristata	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO8414	Crella incrustans	Species	Crellidae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO19014	Palythoa tuberculosa	Species	Sphenopidae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO25358	Senecio gilliesi	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO3017	Artemisia caucasica	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO18723	Zanthoxylum avicennae	Species	Rutaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO25802	Agave deserti	Species	Asparagaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO21776	Sesbania grandiflora	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO29285	Dendrobium densiflorum	Species	Orchidaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO17552	Senecio flammeus	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO2775	Cyathula officinalis	Species	Amaranthaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO26277	Euphorbia hirta	Species	Euphorbiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO11100	Artemisia capillaris	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO21610	Laurencia rigida	Species	Rhodomelaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO17727	Bothriocline amplifolia	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO9650	Zanthoxylum nitidum	Species	Rutaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO26849	Parmelia zollingeri	Species	Parmeliaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO4878	Agathosma cedrimontana	Species	Rutaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO25122	Conium maculatum	Species	Apiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO10560	Adenia fruticosa	Species	Passifloraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO8500	Acanthopanax gracilistylus	Species	Araliaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO9781	Hyphear tanakae	n.a.	n.a.	n.a.	n.a.	n.a.	n.a.	Database[UNPD]
NPO9018	Millettia rubiginosa	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO5933	Drimia fugax	Species	Hyacinthaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO19787	Citrus sinensis	Species	Rutaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO851	Eupatorium lindleyanum	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO20419	Buxus wallichiana	Species	Buxaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO12874	Sedum cepaea	Species	Crassulaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO1803	Enantia chlorantha	Species	Pieridae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO16343	Galium album	Species	Rubiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO20900	Dendrobium chrysotoxum	Species	Orchidaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO25094	Artemisia princeps	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO23639	Cynanchum viminale	Species	Apocynaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO6669	Dysosma delavayi	Species	Berberidaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO19133	Brickellia baccharidea	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO13704	Endarachne binghamiae	Species	Scytosiphonaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO10474	Latrunculia brevis	Species	Latrunculiidae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO17426	Vismia baccifera	Species	Hypericaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO22272	Raphanus raphanistrum	Species	Brassicaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO14761	Serratula wolffii	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO20885	Duguetia furfuracea	Species	Annonaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO4970	Torricellia tiliifolia	Species	Torricelliaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO21334	Artemisia dracunculus	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO10763	Aralia dasyphylla	Species	Araliaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO9648	Maharanga bicolor	Species	Boraginaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO2291	Saussurea pulchella	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO14650	Lobelia chinensis	Species	Campanulaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO14773	Uncaria perrottetii	Species	Rubiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO10464	Epipedobates anthonyi	Species	Dendrobatidae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO13854	Prunus serotina	Species	Rosaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO9150	Polypodiodes formosana	Species	Polypodiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO8884	Cuscuta reflexa	Species	Convolvulaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO13313	Talipariti tiliaceum	Species	Malvaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO6425	Betula davurica	Species	Betulaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO22788	Barnettia kerrii	n.a.	n.a.	n.a.	n.a.	n.a.	n.a.	Database[UNPD]
NPO59	Fusarium dimerum	Species	Nectriaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO26160	Thielavia terricola	Species	Chaetomiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO5740	Phellodendron japonicum	Species	Rutaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO8707.1	Pueraria montana var. lobata	Varieties	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO24758	Angelica dahurica	Species	Apiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO14938	Cybister lateralimarginalis	Species	Dytiscidae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO2704	Veratrum sabadilla	Species	Melanthiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO15289	Scoparia dulcis	Species	Plantaginaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO22670	Phebalium bilobum	Species	Rutaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO3894	Dendrobium nobile	Species	Orchidaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO21413	Armillaria tabescens	Species	Physalacriaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO2188	Dendrobium candidum	Species	Orchidaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO6235	Exobasidium vaccinii	Species	Exobasidiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO12176	Streptomyces olivaceus	Species	Streptomycetaceae	Bacteria	n.a.	n.a.	n.a.	Database[UNPD]
NPO22212	Rhizophora mangle	Species	Rhizophoraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO19561	Garcinia conrauana	Species	Clusiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO25714	Solanum spirale	Species	Solanaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO25406	Celastrus monospermus	Species	Celastraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO22264	Inula salsoloides	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO22890	Eutrochium purpureum	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO20210	Lophozia floerkei	Species	Scapaniaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO12659	Hopea brevipetiolaris	Species	Dipterocarpaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO26789	Tephrosia bidwilli	Species	Geometridae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO5895	Hibiscus taiwanensis	Species	Malvaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO26409	Plakortis simplex	Species	Plakinidae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO16988	Pseudodistoma novaezelandiae	Species	Pseudodistomidae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO638	Aralia fargesii	Species	Araliaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO9366	Rosa transmorrisonensis	Species	Rosaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO12422	Pinus massoniana	Species	Pinaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO25833	Asclepias subulata	Species	Apocynaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO10506	Artemisia apiacea	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO1164	Osteospermum hyoseroides	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO18265	Citrus tamurana	Species	Rutaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO3005	Passiflora morifolia	Species	Passifloraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO26690	Lactarius subpiperatus	Species	Lactariidae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO25201	Aglaia pyramidata	Species	Meliaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO4033	Corydalis gigantea	Species	Papaveraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO21387	Forsythia suspensa	Species	Oleaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO10719	Centrosema haitense	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO11889	Dendrobium chrysanthum	Species	Orchidaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO17456	Echinochloa esculenta	Species	Poaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO15750	Thymus nummularius	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO19215	Ormosia semicastrata	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO20787	Achyranthes aspera	Species	Amaranthaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO23332	Dendrobium fimbriatum	Species	Orchidaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO21341	Morus macroura	Species	Moraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO24478	Morinda coreia	Species	Rubiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO11186	Duranta erecta	Species	Verbenaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO12674	Colchicum ritchii	Species	Colchicaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]

☑ Note for Reference:
In addition to directly collecting NP source organism data from primary literature (where reference will provided as NCBI PMID or DOI links), NPASS also integrated them from below databases:
☉ UNPD: Universal Natural Products Database [PMID: 23638153].
☉ StreptomeDB: a database of streptomycetes natural products [PMID: 33051671].
☉ TM-MC: a database of medicinal materials and chemical compounds in Northeast Asian traditional medicine [PMID: 26156871].
☉ TCM@Taiwan: a Traditional Chinese Medicine database [PMID: 21253603].
☉ TCMID: a Traditional Chinese Medicine database [PMID: 29106634].
☉ TCMSP: The traditional Chinese medicine systems pharmacology database and analysis platform [PMID: 24735618].
☉ HerDing: a herb recommendation system to treat diseases using genes and chemicals [PMID: 26980517].
☉ MetaboLights: a metabolomics database [PMID: 27010336].
☉ FooDB: a database of constituents, chemistry and biology of food species [www.foodb.ca].

NP Quantity Composition/Concentration

Organism ID	NP ID	Organism Material Preparation	Organism Part	NP Quantity (Standard)	NP Quantity (Minimum)	NP Quantity (Maximum)	Quantity Unit	Reference
NPO19787	NPC240722	Raw	Bark	16.2	16.2	16.2	mg/100g	Database [DUKE]
NPO21334	NPC240722	Other	Shoot	0.8	0.8	0.8	mg/100g	Database [DUKE]

☑ Note for Reference:
In addition to directly collecting NP quantitative data from primary literature (where reference will provided as NCBI PMID or DOI links), NPASS also integrated NP quantitative records for specific NP domains (e.g., NPS from foods or herbs) from domain-specific databases. These databases include:
☉ DUKE: Dr. Duke's Phytochemical and Ethnobotanical Databases.
☉ PHENOL EXPLORER: is the first comprehensive database on polyphenol content in foods [PMID: 24103452], its homepage can be accessed at here.
☉ FooDB: a database of constituents, chemistry and biology of food species [www.foodb.ca].

Biological Activity

Activity Type	# Activity
EC50	1
ED50	1
IC50	17
Ki	1
MIC	9
Others	5

Activity Type	# Activity
Cell Line	6
Individual Protein	4
NON-MOLECULAR	14
Organism	9
Others	1

Target ID	Target Type	Target Name	Target Organism	Activity Type	Activity Relation	Value	Unit	Reference
NPT2740	Cell Line	Neutrophils		IC50	>	100000.0	nM	PMID[540573]
NPT81	Cell Line	A549	Homo sapiens	IC50	>	100000.0	nM	PMID[540580]
NPT579	Cell Line	DLD-1	Homo sapiens	IC50	>	100000.0	nM	PMID[540580]
NPT466	Cell Line	U-937	Homo sapiens	CC50	=	1289000.0	nM	PMID[540582]
NPT466	Cell Line	U-937	Homo sapiens	IC50	=	589900.0	nM	PMID[540582]
NPT116	Cell Line	HL-60	Homo sapiens	IC50	=	1.1	ug.mL-1	PMID[540585]
NPT57	Individual Protein	Induced myeloid leukemia cell differentiation protein Mcl-1	Homo sapiens	Ki	=	9540.0	nM	PMID[540586]
NPT57	Individual Protein	Induced myeloid leukemia cell differentiation protein Mcl-1	Homo sapiens	IC50	=	25140.0	nM	PMID[540586]
NPT20529	NON-MOLECULAR	NON-PROTEIN TARGET	n.a.	IC50	>	50000.0	nM	PMID[540574]
NPT20529	NON-MOLECULAR	NON-PROTEIN TARGET	n.a.	IC50	=	42860.0	nM	PMID[540574]
NPT140	Organism	Artemia	Artemia	LC50	=	349.0	ppm	PMID[540575]
NPT20529	NON-MOLECULAR	NON-PROTEIN TARGET	n.a.	ED50	=	61.0	ug ml-1	PMID[540575]
NPT20529	NON-MOLECULAR	NON-PROTEIN TARGET	n.a.	IC50	=	41400.0	nM	PMID[540576]
NPT20529	NON-MOLECULAR	NON-PROTEIN TARGET	n.a.	IC50	>	50000.0	nM	PMID[540576]
NPT88	Organism	Mycobacterium tuberculosis	Mycobacterium tuberculosis	MIC	=	388000.0	nM	PMID[540577]
NPT20529	NON-MOLECULAR	NON-PROTEIN TARGET	n.a.	IC50	>	30000.0	nM	PMID[540578]
NPT20529	NON-MOLECULAR	NON-PROTEIN TARGET	n.a.	IC50	=	8.25	ug.mL-1	PMID[540579]
NPT20529	NON-MOLECULAR	NON-PROTEIN TARGET	n.a.	Inhibition	=	43.1	%	PMID[540579]
NPT20529	NON-MOLECULAR	NON-PROTEIN TARGET	n.a.	IC50	>	100000.0	nM	PMID[540580]
NPT740	Individual Protein	Beta-secretase 1	Homo sapiens	IC50	>	500000.0	nM	PMID[540581]
NPT740	Individual Protein	Beta-secretase 1	Homo sapiens	Inhibition	=	6.2	%	PMID[540581]
NPT20529	NON-MOLECULAR	NON-PROTEIN TARGET	n.a.	Emax	=	100.0	%	PMID[540583]
NPT20529	NON-MOLECULAR	NON-PROTEIN TARGET	n.a.	EC50	=	80000.0	nM	PMID[540583]
NPT20529	NON-MOLECULAR	NON-PROTEIN TARGET	n.a.	IC50	=	54400.0	nM	PMID[540584]
NPT2	Others	Unspecified		IC50	=	11400.0	nM	PMID[540584]
NPT79	Organism	Bacillus subtilis	Bacillus subtilis	MIC	>	1.0	ug.mL-1	PMID[540584]
NPT16	Organism	Staphylococcus aureus	Staphylococcus aureus	MIC	>	1.0	ug.mL-1	PMID[540584]
NPT19	Organism	Escherichia coli	Escherichia coli	MIC	>	1.0	ug.mL-1	PMID[540584]
NPT2526	Organism	Rhizomucor miehei	Rhizomucor miehei	MIC	>	1.0	ug.mL-1	PMID[540584]
NPT20	Organism	Candida albicans	Candida albicans	MIC	>	1.0	ug.mL-1	PMID[540584]
NPT20529	NON-MOLECULAR	NON-PROTEIN TARGET	n.a.	MIC	>	1.0	ug.mL-1	PMID[540584]
NPT2527	Organism	Pythium ultimum	Pythium ultimum	MIC	>	1.0	ug.mL-1	PMID[540584]
NPT529	Organism	Rhizoctonia solani	Rhizoctonia solani	MIC	>	1.0	ug.mL-1	PMID[540584]

☑ Note for Activity Records:
☉ The quantitative biological activities were primarily integrated from ChEMBL (Version-30) database and were also directly collected from PubMed literature. PubMed PMID was provided as the reference link for each activity record.

Chemically structural similarity: I. Similar Active Natural Products in NPASS

Top-200 similar NPs were calculated against the active-NP-set (includes 4,3285 NPs with experimentally-derived bioactivity available in NPASS)

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules. Tc lies between [0, 1] where '1' indicates the highest similarity. What is Tanimoto coefficient

● The left chart: Distribution of similarity level between NPC240722 and all remaining natural products in the NPASS database.
● The right table: Most similar natural products (Tc>=0.56 or Top200).

range	Tanimoto Coefficient
0-0.1	516
0.1-0.2	2236
0.2-0.3	6109
0.3-0.4	11599
0.4-0.5	4922
0.5-0.6	4424
0.6-0.7	5726
0.7-0.8	5133
0.8-0.85	1455
0.85-0.9	502
0.9-0.95	63
0.95-1	12

Similarity Score	Similarity Level	Natural Product ID
1.0	High Similarity	NPC244799
0.9919	High Similarity	NPC123127
0.9919	High Similarity	NPC27239
0.984	High Similarity	NPC137669
0.9762	High Similarity	NPC241341
0.9762	High Similarity	NPC233018
0.9762	High Similarity	NPC36437
0.9685	High Similarity	NPC309953
0.9535	High Similarity	NPC167517
0.9528	High Similarity	NPC319969
0.9524	High Similarity	NPC19242
0.9462	High Similarity	NPC139548
0.9462	High Similarity	NPC148835
0.9462	High Similarity	NPC20796
0.9462	High Similarity	NPC20511
0.9462	High Similarity	NPC52086
0.9462	High Similarity	NPC95162
0.9462	High Similarity	NPC76336
0.9457	High Similarity	NPC240915
0.9457	High Similarity	NPC234865
0.9389	High Similarity	NPC164148
0.9389	High Similarity	NPC13067
0.9389	High Similarity	NPC43500
0.9389	High Similarity	NPC270256
0.9385	High Similarity	NPC126682
0.9385	High Similarity	NPC82271
0.9385	High Similarity	NPC286843
0.938	High Similarity	NPC7163
0.9308	High Similarity	NPC73071
0.9302	High Similarity	NPC472522
0.9248	High Similarity	NPC300611
0.9231	High Similarity	NPC474600
0.9231	High Similarity	NPC92830
0.9225	High Similarity	NPC123954
0.9213	High Similarity	NPC474616
0.9154	High Similarity	NPC26673
0.9134	High Similarity	NPC474670
0.9134	High Similarity	NPC194841
0.9111	High Similarity	NPC138212
0.9084	High Similarity	NPC147030
0.9077	High Similarity	NPC137949
0.9062	High Similarity	NPC474651
0.9062	High Similarity	NPC474623
0.9055	High Similarity	NPC127604
0.904	High Similarity	NPC194626
0.9024	High Similarity	NPC298796
0.9015	High Similarity	NPC472521
0.9008	High Similarity	NPC277021
0.9	High Similarity	NPC73738
0.8984	High Similarity	NPC474821
0.8971	High Similarity	NPC7439
0.8971	High Similarity	NPC34245
0.8971	High Similarity	NPC256555
0.8971	High Similarity	NPC236419
0.8971	High Similarity	NPC91492
0.8971	High Similarity	NPC110067
0.8952	High Similarity	NPC222175
0.8943	High Similarity	NPC152306
0.8943	High Similarity	NPC265547
0.8923	High Similarity	NPC476399
0.8913	High Similarity	NPC205361
0.8906	High Similarity	NPC474632
0.8889	High Similarity	NPC288238
0.888	High Similarity	NPC163200
0.8871	High Similarity	NPC281356
0.8849	High Similarity	NPC15577
0.8849	High Similarity	NPC231149
0.8841	High Similarity	NPC476450
0.8832	High Similarity	NPC230157
0.881	High Similarity	NPC310373
0.879	High Similarity	NPC96705
0.8788	High Similarity	NPC245120
0.8788	High Similarity	NPC5423
0.8786	High Similarity	NPC139839
0.8786	High Similarity	NPC96294
0.878	High Similarity	NPC128633
0.8779	High Similarity	NPC474617
0.8769	High Similarity	NPC474636
0.8769	High Similarity	NPC210674
0.8741	High Similarity	NPC474530
0.8741	High Similarity	NPC474521
0.8741	High Similarity	NPC38874
0.8741	High Similarity	NPC474540
0.8731	High Similarity	NPC224941
0.8731	High Similarity	NPC311430
0.873	High Similarity	NPC235190
0.873	High Similarity	NPC180006
0.8723	High Similarity	NPC176903
0.8723	High Similarity	NPC30688
0.872	High Similarity	NPC308217
0.871	High Similarity	NPC304208
0.871	High Similarity	NPC52464
0.8686	High Similarity	NPC472520
0.8686	High Similarity	NPC279851
0.8682	High Similarity	NPC27352
0.8672	High Similarity	NPC108545
0.8672	High Similarity	NPC273772
0.8672	High Similarity	NPC472518
0.8672	High Similarity	NPC109675
0.8662	High Similarity	NPC21184
0.8662	High Similarity	NPC120426
0.8662	High Similarity	NPC205727
0.8662	High Similarity	NPC294522
0.8662	High Similarity	NPC114740
0.8661	High Similarity	NPC144418
0.8657	High Similarity	NPC111635
0.8652	High Similarity	NPC48366
0.8636	High Similarity	NPC307042
0.8636	High Similarity	NPC79184
0.8633	High Similarity	NPC185127
0.8633	High Similarity	NPC471763
0.8626	High Similarity	NPC199204
0.8618	High Similarity	NPC87563
0.8615	High Similarity	NPC101894
0.8605	High Similarity	NPC73413
0.8605	High Similarity	NPC27671
0.8605	High Similarity	NPC201667
0.8603	High Similarity	NPC476171
0.8603	High Similarity	NPC474886
0.8601	High Similarity	NPC213197
0.8594	High Similarity	NPC96286
0.8594	High Similarity	NPC248429
0.8592	High Similarity	NPC212670
0.8592	High Similarity	NPC206264
0.8592	High Similarity	NPC313334
0.8583	High Similarity	NPC267064
0.8582	High Similarity	NPC476347
0.8582	High Similarity	NPC474810
0.8582	High Similarity	NPC167111
0.8582	High Similarity	NPC318400
0.8582	High Similarity	NPC133956
0.8582	High Similarity	NPC296624
0.8582	High Similarity	NPC207002
0.8582	High Similarity	NPC178129
0.8582	High Similarity	NPC471910
0.8561	High Similarity	NPC6568
0.8561	High Similarity	NPC153547
0.8561	High Similarity	NPC168710
0.8542	High Similarity	NPC264875
0.8542	High Similarity	NPC163598
0.8542	High Similarity	NPC120774
0.8538	High Similarity	NPC471827
0.8538	High Similarity	NPC471828
0.8538	High Similarity	NPC300326
0.8538	High Similarity	NPC58279
0.8527	High Similarity	NPC154176
0.8527	High Similarity	NPC173350
0.8527	High Similarity	NPC315807
0.8527	High Similarity	NPC290605
0.8521	High Similarity	NPC476348
0.8521	High Similarity	NPC187398
0.8519	High Similarity	NPC55149
0.8519	High Similarity	NPC100986
0.8519	High Similarity	NPC195343
0.8519	High Similarity	NPC47163
0.8519	High Similarity	NPC287182
0.8519	High Similarity	NPC267412
0.8519	High Similarity	NPC84894
0.8519	High Similarity	NPC319859
0.8519	High Similarity	NPC18804
0.8519	High Similarity	NPC166672
0.8519	High Similarity	NPC260265
0.8519	High Similarity	NPC198381
0.8519	High Similarity	NPC164269
0.8519	High Similarity	NPC127888
0.8519	High Similarity	NPC307412
0.8519	High Similarity	NPC74655
0.8507	High Similarity	NPC14248
0.8496	Intermediate Similarity	NPC80170
0.8492	Intermediate Similarity	NPC124916
0.8489	Intermediate Similarity	NPC469564
0.8485	Intermediate Similarity	NPC109275
0.8485	Intermediate Similarity	NPC185066
0.8473	Intermediate Similarity	NPC234109
0.8473	Intermediate Similarity	NPC188327
0.8473	Intermediate Similarity	NPC471826
0.8473	Intermediate Similarity	NPC244364
0.8462	Intermediate Similarity	NPC283170
0.8462	Intermediate Similarity	NPC191768
0.8462	Intermediate Similarity	NPC111347
0.8462	Intermediate Similarity	NPC92869
0.8456	Intermediate Similarity	NPC472424
0.8456	Intermediate Similarity	NPC471625
0.8456	Intermediate Similarity	NPC469675
0.8456	Intermediate Similarity	NPC33986
0.8456	Intermediate Similarity	NPC281241
0.8456	Intermediate Similarity	NPC471909
0.8456	Intermediate Similarity	NPC86892
0.8451	Intermediate Similarity	NPC41844
0.8451	Intermediate Similarity	NPC52740
0.845	Intermediate Similarity	NPC270326
0.845	Intermediate Similarity	NPC257188
0.845	Intermediate Similarity	NPC211231
0.845	Intermediate Similarity	NPC13007
0.8444	Intermediate Similarity	NPC222036
0.8444	Intermediate Similarity	NPC7526
0.8438	Intermediate Similarity	NPC319378
0.8438	Intermediate Similarity	NPC302107
0.8438	Intermediate Similarity	NPC472596
0.8433	Intermediate Similarity	NPC142530

Chemically structural similarity: II. Similar Clinical/Approved Drugs

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules.

● The left chart: Distribution of similarity level between NPC240722 and all drugs/candidates.
● The right table: Most similar clinical/approved drugs (Tc>=0.56 or Top200).

range	Tanimoto Coefficient
0-0.1	458
0.1-0.2	1043
0.2-0.3	2070
0.3-0.4	2663
0.4-0.5	1617
0.5-0.6	865
0.6-0.7	298
0.7-0.8	102
0.8-0.85	27
0.85-0.9	7
0.9-0.95	0
0.95-1	0

Similarity Score	Similarity Level	Drug ID	Developmental Stage
0.8592	High Similarity	NPD1653	Approved
0.8372	Intermediate Similarity	NPD422	Phase 1
0.8194	Intermediate Similarity	NPD1940	Clinical (unspecified phase)
0.8074	Intermediate Similarity	NPD1008	Clinical (unspecified phase)
0.7941	Intermediate Similarity	NPD1529	Clinical (unspecified phase)
0.7914	Intermediate Similarity	NPD447	Suspended
0.7902	Intermediate Similarity	NPD1652	Phase 2
0.7886	Intermediate Similarity	NPD9697	Approved
0.7881	Intermediate Similarity	NPD3817	Phase 2
0.7868	Intermediate Similarity	NPD3018	Phase 2
0.7868	Intermediate Similarity	NPD1530	Clinical (unspecified phase)
0.7843	Intermediate Similarity	NPD919	Approved
0.7842	Intermediate Similarity	NPD1612	Clinical (unspecified phase)
0.7842	Intermediate Similarity	NPD1613	Approved
0.7826	Intermediate Similarity	NPD1296	Phase 2
0.7815	Intermediate Similarity	NPD2801	Approved
0.7761	Intermediate Similarity	NPD2981	Phase 2
0.776	Intermediate Similarity	NPD1358	Approved
0.7744	Intermediate Similarity	NPD3496	Discontinued
0.771	Intermediate Similarity	NPD5536	Phase 2
0.7704	Intermediate Similarity	NPD2983	Phase 2
0.7704	Intermediate Similarity	NPD2982	Phase 2
0.7673	Intermediate Similarity	NPD5844	Phase 1
0.7628	Intermediate Similarity	NPD1247	Approved
0.7626	Intermediate Similarity	NPD3027	Phase 3
0.7622	Intermediate Similarity	NPD3748	Approved
0.7593	Intermediate Similarity	NPD7549	Discontinued
0.7571	Intermediate Similarity	NPD6859	Clinical (unspecified phase)
0.7568	Intermediate Similarity	NPD1511	Approved
0.7564	Intermediate Similarity	NPD5494	Approved
0.7556	Intermediate Similarity	NPD1611	Approved
0.7535	Intermediate Similarity	NPD5124	Phase 1
0.7535	Intermediate Similarity	NPD230	Phase 1
0.7535	Intermediate Similarity	NPD5123	Clinical (unspecified phase)
0.7535	Intermediate Similarity	NPD1933	Approved
0.7533	Intermediate Similarity	NPD6980	Clinical (unspecified phase)
0.7519	Intermediate Similarity	NPD1548	Phase 1
0.7516	Intermediate Similarity	NPD1934	Approved
0.7484	Intermediate Similarity	NPD4868	Clinical (unspecified phase)
0.7468	Intermediate Similarity	NPD1465	Phase 2
0.7467	Intermediate Similarity	NPD1512	Approved
0.7467	Intermediate Similarity	NPD7314	Clinical (unspecified phase)
0.7466	Intermediate Similarity	NPD970	Clinical (unspecified phase)
0.745	Intermediate Similarity	NPD6799	Approved
0.7426	Intermediate Similarity	NPD3705	Approved
0.7419	Intermediate Similarity	NPD5402	Approved
0.7417	Intermediate Similarity	NPD920	Approved
0.7415	Intermediate Similarity	NPD1243	Approved
0.7413	Intermediate Similarity	NPD1899	Clinical (unspecified phase)
0.7405	Intermediate Similarity	NPD5283	Phase 1
0.7402	Intermediate Similarity	NPD3134	Approved
0.7391	Intermediate Similarity	NPD3225	Approved
0.7372	Intermediate Similarity	NPD3882	Suspended
0.7365	Intermediate Similarity	NPD3750	Approved
0.7342	Intermediate Similarity	NPD5677	Discontinued
0.7333	Intermediate Similarity	NPD5691	Approved
0.7329	Intermediate Similarity	NPD1551	Phase 2
0.7329	Intermediate Similarity	NPD2796	Approved
0.7329	Intermediate Similarity	NPD3539	Phase 1
0.7328	Intermediate Similarity	NPD5535	Approved
0.7319	Intermediate Similarity	NPD4379	Clinical (unspecified phase)
0.7308	Intermediate Similarity	NPD5353	Approved
0.7299	Intermediate Similarity	NPD1610	Phase 2
0.7286	Intermediate Similarity	NPD1019	Discontinued
0.7285	Intermediate Similarity	NPD642	Clinical (unspecified phase)
0.7279	Intermediate Similarity	NPD3540	Phase 1
0.7279	Intermediate Similarity	NPD1778	Approved
0.7273	Intermediate Similarity	NPD4338	Clinical (unspecified phase)
0.7267	Intermediate Similarity	NPD643	Clinical (unspecified phase)
0.7252	Intermediate Similarity	NPD228	Approved
0.7248	Intermediate Similarity	NPD6398	Clinical (unspecified phase)
0.7246	Intermediate Similarity	NPD9717	Approved
0.7244	Intermediate Similarity	NPD2393	Clinical (unspecified phase)
0.7219	Intermediate Similarity	NPD5297	Approved
0.7219	Intermediate Similarity	NPD4357	Discontinued
0.7214	Intermediate Similarity	NPD3266	Approved
0.7214	Intermediate Similarity	NPD3267	Approved
0.7211	Intermediate Similarity	NPD2935	Discontinued
0.7188	Intermediate Similarity	NPD7199	Phase 2
0.7183	Intermediate Similarity	NPD6832	Phase 2
0.7183	Intermediate Similarity	NPD4908	Phase 1
0.7178	Intermediate Similarity	NPD3818	Discontinued
0.7174	Intermediate Similarity	NPD1091	Approved
0.7171	Intermediate Similarity	NPD5401	Approved
0.7161	Intermediate Similarity	NPD6599	Discontinued
0.7153	Intermediate Similarity	NPD4626	Approved
0.7153	Intermediate Similarity	NPD17	Approved
0.7143	Intermediate Similarity	NPD1241	Discontinued
0.7143	Intermediate Similarity	NPD6232	Discontinued
0.7134	Intermediate Similarity	NPD7054	Approved
0.7134	Intermediate Similarity	NPD7819	Suspended
0.7134	Intermediate Similarity	NPD7096	Clinical (unspecified phase)
0.7123	Intermediate Similarity	NPD2653	Approved
0.7105	Intermediate Similarity	NPD6143	Clinical (unspecified phase)
0.7103	Intermediate Similarity	NPD4307	Phase 2
0.7103	Intermediate Similarity	NPD4060	Phase 1
0.7099	Intermediate Similarity	NPD3926	Phase 2
0.7099	Intermediate Similarity	NPD5242	Approved
0.7099	Intermediate Similarity	NPD7184	Clinical (unspecified phase)
0.7092	Intermediate Similarity	NPD2797	Approved
0.7092	Intermediate Similarity	NPD1203	Approved
0.7091	Intermediate Similarity	NPD7472	Approved
0.7086	Intermediate Similarity	NPD5307	Clinical (unspecified phase)
0.7083	Intermediate Similarity	NPD411	Approved
0.7083	Intermediate Similarity	NPD4907	Clinical (unspecified phase)
0.708	Intermediate Similarity	NPD5585	Approved
0.7078	Intermediate Similarity	NPD5403	Approved
0.7077	Intermediate Similarity	NPD290	Approved
0.7071	Intermediate Similarity	NPD4749	Approved
0.707	Intermediate Similarity	NPD6801	Discontinued
0.707	Intermediate Similarity	NPD37	Approved
0.7059	Intermediate Similarity	NPD4378	Clinical (unspecified phase)
0.7055	Intermediate Similarity	NPD4340	Discontinued
0.7055	Intermediate Similarity	NPD6166	Phase 2
0.7055	Intermediate Similarity	NPD6167	Clinical (unspecified phase)
0.7055	Intermediate Similarity	NPD6168	Clinical (unspecified phase)
0.7047	Intermediate Similarity	NPD7266	Discontinued
0.7044	Intermediate Similarity	NPD4967	Phase 2
0.7044	Intermediate Similarity	NPD4965	Approved
0.7044	Intermediate Similarity	NPD4966	Approved
0.7037	Intermediate Similarity	NPD6671	Approved
0.7034	Intermediate Similarity	NPD6233	Phase 2
0.7032	Intermediate Similarity	NPD3686	Approved
0.7032	Intermediate Similarity	NPD3687	Approved
0.7027	Intermediate Similarity	NPD1510	Phase 2
0.702	Intermediate Similarity	NPD1878	Clinical (unspecified phase)
0.7012	Intermediate Similarity	NPD7473	Discontinued
0.7006	Intermediate Similarity	NPD5089	Approved
0.7006	Intermediate Similarity	NPD6385	Approved
0.7006	Intermediate Similarity	NPD5090	Approved
0.7006	Intermediate Similarity	NPD6386	Approved
0.7	Intermediate Similarity	NPD1549	Phase 2
0.7	Intermediate Similarity	NPD1608	Approved
0.7	Intermediate Similarity	NPD7075	Discontinued
0.6993	Remote Similarity	NPD2237	Approved
0.6993	Remote Similarity	NPD2861	Phase 2
0.6988	Remote Similarity	NPD7074	Phase 3
0.6986	Remote Similarity	NPD1240	Approved
0.6975	Remote Similarity	NPD8127	Discontinued
0.6974	Remote Similarity	NPD6190	Approved
0.6974	Remote Similarity	NPD2219	Phase 1
0.6971	Remote Similarity	NPD6621	Clinical (unspecified phase)
0.6966	Remote Similarity	NPD3268	Approved
0.6964	Remote Similarity	NPD7808	Phase 3
0.6957	Remote Similarity	NPD6234	Discontinued
0.6957	Remote Similarity	NPD9268	Approved
0.6948	Remote Similarity	NPD3146	Approved
0.6948	Remote Similarity	NPD3688	Clinical (unspecified phase)
0.6946	Remote Similarity	NPD7993	Clinical (unspecified phase)
0.6946	Remote Similarity	NPD6797	Phase 2
0.6943	Remote Similarity	NPD4675	Approved
0.6943	Remote Similarity	NPD4678	Approved
0.6933	Remote Similarity	NPD1375	Discontinued
0.6933	Remote Similarity	NPD1552	Clinical (unspecified phase)
0.6933	Remote Similarity	NPD1550	Clinical (unspecified phase)
0.6929	Remote Similarity	NPD1535	Discovery
0.6918	Remote Similarity	NPD4585	Approved
0.6913	Remote Similarity	NPD4308	Phase 3
0.6908	Remote Similarity	NPD4628	Phase 3
0.6908	Remote Similarity	NPD4109	Clinical (unspecified phase)
0.6908	Remote Similarity	NPD4110	Phase 3
0.6905	Remote Similarity	NPD7251	Discontinued
0.6903	Remote Similarity	NPD3647	Clinical (unspecified phase)
0.6899	Remote Similarity	NPD7411	Suspended
0.6897	Remote Similarity	NPD7095	Approved
0.6897	Remote Similarity	NPD4625	Phase 3
0.6894	Remote Similarity	NPD2684	Approved
0.6894	Remote Similarity	NPD4381	Clinical (unspecified phase)
0.6892	Remote Similarity	NPD1607	Approved
0.6883	Remote Similarity	NPD7837	Clinical (unspecified phase)
0.6879	Remote Similarity	NPD6055	Clinical (unspecified phase)
0.6879	Remote Similarity	NPD1481	Phase 2
0.6879	Remote Similarity	NPD8158	Clinical (unspecified phase)
0.6879	Remote Similarity	NPD9269	Phase 2
0.6875	Remote Similarity	NPD9494	Approved
0.6871	Remote Similarity	NPD1558	Phase 1
0.687	Remote Similarity	NPD968	Approved
0.6849	Remote Similarity	NPD6798	Discontinued
0.6849	Remote Similarity	NPD6410	Clinical (unspecified phase)
0.6846	Remote Similarity	NPD6111	Discontinued
0.6842	Remote Similarity	NPD7421	Clinical (unspecified phase)
0.6839	Remote Similarity	NPD1424	Approved
0.6835	Remote Similarity	NPD4380	Phase 2
0.6835	Remote Similarity	NPD1357	Approved
0.6832	Remote Similarity	NPD7768	Phase 2
0.6831	Remote Similarity	NPD4359	Approved
0.6828	Remote Similarity	NPD5752	Clinical (unspecified phase)
0.6824	Remote Similarity	NPD6355	Discontinued
0.6821	Remote Similarity	NPD5763	Approved
0.6821	Remote Similarity	NPD5762	Approved
0.6818	Remote Similarity	NPD7124	Phase 2
0.6815	Remote Similarity	NPD7843	Approved
0.6812	Remote Similarity	NPD1408	Clinical (unspecified phase)
0.6812	Remote Similarity	NPD7644	Approved
0.6803	Remote Similarity	NPD1726	Clinical (unspecified phase)
0.679	Remote Similarity	NPD6971	Discontinued
0.6788	Remote Similarity	NPD7157	Approved
0.6783	Remote Similarity	NPD2922	Phase 1
0.6783	Remote Similarity	NPD8651	Approved
0.6776	Remote Similarity	NPD2424	Discontinued

Bioactivity similarity: Similar Natural Products in NPASS

Bioactivity similarity was calculated based on bioactivity descriptors of compounds. The bioactivity descriptors were calculated by a recently developed AI algorithm Chemical Checker (CC) [Nature Biotechnology, 38:1087–1096, 2020; Nature Communications, 12:3932, 2021], which evaluated bioactivity similarities at five levels:
☉ A: chemistry similarity;
☉ B: biological targets similarity;
☉ C: networks similarity;
☉ D: cell-based bioactivity similarity;
☉ E: similarity based on clinical data.

Those 5 categories of CC bioactivity descriptors were calculated and then subjected to manifold projection using UMAP algorithm, to project all NPs on a 2-Dimensional space. The current NP was highlighted with a small circle in the 2-D map. Below figures: left-to-right, A-to-E.

A: chemistry similarity

B: biological targets similarity

C: networks similarity

D: cell-based bioactivity similarity

E: similarity based on clinical data